RLN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the relaxin family of insulin-like hormones that is expressed predominantly in the brain and plays a role in physiological processes such as stress, memory and appetite regulation. The encoded protein is a precursor that is proteolytically processed to generate a heterodimeric mature form consisting A and B chains interlinked by disulfide bonds. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.55480429
2attachment of spindle microtubules to kinetochore (GO:0008608)5.00655473
3metaphase plate congression (GO:0051310)4.84230055
4maturation of 5.8S rRNA (GO:0000460)4.60659489
5piRNA metabolic process (GO:0034587)4.51790689
6DNA deamination (GO:0045006)4.46468222
7establishment of chromosome localization (GO:0051303)4.42938587
8histone H2A monoubiquitination (GO:0035518)4.33255154
9sequestering of actin monomers (GO:0042989)4.21805633
10regulation of exit from mitosis (GO:0007096)4.16694415
11cellular response to interleukin-15 (GO:0071350)4.04004681
12mitotic nuclear envelope disassembly (GO:0007077)3.93295789
13mitotic chromosome condensation (GO:0007076)3.90495113
14mitotic sister chromatid segregation (GO:0000070)3.82507183
15CENP-A containing nucleosome assembly (GO:0034080)3.79598289
16meiotic cell cycle (GO:0051321)3.78600918
17regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.75019455
18protein localization to kinetochore (GO:0034501)3.74865073
19nuclear envelope disassembly (GO:0051081)3.72289930
20membrane disassembly (GO:0030397)3.72289930
21female gamete generation (GO:0007292)3.68816785
22chromatin remodeling at centromere (GO:0031055)3.62413818
23negative thymic T cell selection (GO:0045060)3.61033425
24regulation of sister chromatid cohesion (GO:0007063)3.55626400
25positive thymic T cell selection (GO:0045059)3.54056886
26negative T cell selection (GO:0043383)3.49802961
27DNA replication checkpoint (GO:0000076)3.48155153
28DNA replication-independent nucleosome organization (GO:0034724)3.47054019
29DNA replication-independent nucleosome assembly (GO:0006336)3.47054019
30negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.46146946
31negative regulation of meiosis (GO:0045835)3.45901305
32protein localization to chromosome, centromeric region (GO:0071459)3.45794578
33DNA replication initiation (GO:0006270)3.41301216
34histone H2A ubiquitination (GO:0033522)3.41278758
35regulation of spindle organization (GO:0090224)3.36731985
36regulation of histone H3-K27 methylation (GO:0061085)3.33158688
37meiotic chromosome segregation (GO:0045132)3.33130474
38positive regulation of gamma-delta T cell activation (GO:0046645)3.32915978
39response to interleukin-15 (GO:0070672)3.29702703
40regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.29603133
41negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.29220378
42negative regulation of chromosome segregation (GO:0051985)3.28646019
43histone exchange (GO:0043486)3.28592727
44spindle checkpoint (GO:0031577)3.28436359
45negative regulation of mitotic sister chromatid separation (GO:2000816)3.27508025
46negative regulation of mitotic sister chromatid segregation (GO:0033048)3.27508025
47negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.27508025
48negative regulation of sister chromatid segregation (GO:0033046)3.27508025
49regulation of female gonad development (GO:2000194)3.27478559
50thymic T cell selection (GO:0045061)3.26242295
51DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.24334205
52positive regulation of chromosome segregation (GO:0051984)3.24069800
53male meiosis (GO:0007140)3.23573617
54regulation of mitotic spindle organization (GO:0060236)3.22206454
55regulation of chromosome segregation (GO:0051983)3.21493773
56chromosome segregation (GO:0007059)3.18712641
57DNA damage response, signal transduction resulting in transcription (GO:0042772)3.16204442
58pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.15488090
59regulation of meiosis (GO:0040020)3.15085177
60mitotic spindle checkpoint (GO:0071174)3.15008815
61regulation of mitotic metaphase/anaphase transition (GO:0030071)3.14914105
62rRNA modification (GO:0000154)3.13791540
63ribosome assembly (GO:0042255)3.10842313
64mitotic spindle assembly checkpoint (GO:0007094)3.08972746
65exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.05620456
66sister chromatid segregation (GO:0000819)3.04509277
67DNA replication-dependent nucleosome organization (GO:0034723)3.01845256
68DNA replication-dependent nucleosome assembly (GO:0006335)3.01845256
69spindle assembly checkpoint (GO:0071173)3.00677412
70nuclear envelope organization (GO:0006998)3.00462366
71protein localization to chromosome (GO:0034502)2.99972623
72protein complex localization (GO:0031503)2.98796229
73regulation of sister chromatid segregation (GO:0033045)2.97302514
74regulation of mitotic sister chromatid separation (GO:0010965)2.97302514
75regulation of mitotic sister chromatid segregation (GO:0033047)2.97302514
76establishment of integrated proviral latency (GO:0075713)2.97162820
77leukocyte aggregation (GO:0070486)2.97148546
78DNA methylation involved in gamete generation (GO:0043046)2.96914430
79transcription-coupled nucleotide-excision repair (GO:0006283)2.96793073
80DNA strand elongation involved in DNA replication (GO:0006271)2.96215666
81telomere maintenance via semi-conservative replication (GO:0032201)2.95233432
82telomere maintenance via recombination (GO:0000722)2.94693907
83establishment of viral latency (GO:0019043)2.94163967
847-methylguanosine mRNA capping (GO:0006370)2.92691148
85kinetochore organization (GO:0051383)2.92170328
86nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.89965465
87regulation of meiosis I (GO:0060631)2.88595403
88negative regulation of nuclear division (GO:0051784)2.85777537
89DNA alkylation (GO:0006305)2.85721430
90DNA methylation (GO:0006306)2.85721430
91kinetochore assembly (GO:0051382)2.84386976
927-methylguanosine RNA capping (GO:0009452)2.82881389
93RNA capping (GO:0036260)2.82881389
94DNA strand elongation (GO:0022616)2.82310500
95rRNA methylation (GO:0031167)2.81725109
96oocyte maturation (GO:0001556)2.80615120
97negative regulation of mitosis (GO:0045839)2.79392256
98L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.78917342
99negative regulation of cell division (GO:0051782)2.77164132
100anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.76591429

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.49417925
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.44988845
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.42813696
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.40317691
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.29969340
6AR_21909140_ChIP-Seq_LNCAP_Human2.76175079
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.72220816
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.70992690
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.60954469
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.60575025
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59570653
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.57354227
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.48633266
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.46517410
15MYC_22102868_ChIP-Seq_BL_Human2.46225586
16* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38105955
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38040477
18NANOG_18555785_ChIP-Seq_MESCs_Mouse2.31816443
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.30654576
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20250213
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08856697
22VDR_23849224_ChIP-Seq_CD4+_Human2.04270399
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.00573830
24GABP_19822575_ChIP-Seq_HepG2_Human1.96972070
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88109735
26XRN2_22483619_ChIP-Seq_HELA_Human1.86015679
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83800737
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.80228247
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78160121
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78100793
31KAP1_22055183_ChIP-Seq_ESCs_Mouse1.76484806
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.67678097
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66533904
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65321545
35FOXP3_21729870_ChIP-Seq_TREG_Human1.60950474
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59001729
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56735380
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.56539405
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.54332001
40CIITA_25753668_ChIP-Seq_RAJI_Human1.51723833
41UTX_26944678_Chip-Seq_JUKART_Human1.48083776
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.44159998
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42748995
44MYC_18940864_ChIP-ChIP_HL60_Human1.41927395
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41297747
46KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37557692
47KDM5A_27292631_Chip-Seq_BREAST_Human1.36870904
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.36032541
49MAF_26560356_Chip-Seq_TH2_Human1.33613025
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.32933005
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.31613299
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.30998426
53DCP1A_22483619_ChIP-Seq_HELA_Human1.30923133
54TTF2_22483619_ChIP-Seq_HELA_Human1.30498839
55MYB_26560356_Chip-Seq_TH2_Human1.28056037
56STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28022379
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27760761
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27362820
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26012096
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.25808448
61MAF_26560356_Chip-Seq_TH1_Human1.24863420
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22786279
63MYB_26560356_Chip-Seq_TH1_Human1.22468918
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22343793
65ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.21571602
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20630567
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20272273
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18758367
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18730721
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17381233
71TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15324178
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14833937
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.14164061
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12207576
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10279452
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.08829580
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07754682
78GATA1_26923725_Chip-Seq_HPCs_Mouse1.07585405
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06826130
80FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06110783
81IRF8_22096565_ChIP-ChIP_GC-B_Human1.05438510
82ELK1_19687146_ChIP-ChIP_HELA_Human1.04083475
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03659838
84THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01007266
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98330961
86SPI1_23547873_ChIP-Seq_NB4_Human0.97843583
87NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97534292
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96875179
89TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.95111208
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94334716
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93057859
92NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.92954342
93KAP1_27257070_Chip-Seq_ESCs_Mouse0.92367172
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91104267
95NANOG_18692474_ChIP-Seq_MEFs_Mouse0.90791902
96SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88795550
97CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88493423
98IRF8_21731497_ChIP-ChIP_J774_Mouse0.88173306
99YY1_21170310_ChIP-Seq_MESCs_Mouse0.88066829
100NANOG_21062744_ChIP-ChIP_HESCs_Human0.87359578

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.06292598
2MP0003718_maternal_effect4.31404161
3MP0003763_abnormal_thymus_physiology4.30309939
4MP0010094_abnormal_chromosome_stability3.91324765
5MP0008877_abnormal_DNA_methylation3.88435984
6MP0004957_abnormal_blastocyst_morpholog3.84638192
7MP0003077_abnormal_cell_cycle3.57260599
8MP0003111_abnormal_nucleus_morphology3.41538630
9MP0005671_abnormal_response_to3.36594023
10MP0005451_abnormal_body_composition3.32095745
11MP0003646_muscle_fatigue2.46954685
12MP0008007_abnormal_cellular_replicative2.37812469
13MP0003123_paternal_imprinting2.10575177
14MP0002102_abnormal_ear_morphology2.09228128
15MP0008057_abnormal_DNA_replication2.07158310
16MP0008932_abnormal_embryonic_tissue2.06399805
17MP0001119_abnormal_female_reproductive1.98595285
18MP0003787_abnormal_imprinting1.97462227
19MP0000703_abnormal_thymus_morphology1.97353442
20MP0002398_abnormal_bone_marrow1.86853980
21MP0001730_embryonic_growth_arrest1.85680878
22MP0008058_abnormal_DNA_repair1.84091546
23MP0000350_abnormal_cell_proliferation1.81170562
24MP0009333_abnormal_splenocyte_physiolog1.81108994
25MP0002653_abnormal_ependyma_morphology1.78481291
26MP0005395_other_phenotype1.74021909
27MP0003315_abnormal_perineum_morphology1.73384951
28MP0003699_abnormal_female_reproductive1.71681921
29MP0000685_abnormal_immune_system1.69810428
30MP0000689_abnormal_spleen_morphology1.69317335
31MP0002722_abnormal_immune_system1.68800830
32MP0001529_abnormal_vocalization1.64262421
33MP0006292_abnormal_olfactory_placode1.61554935
34MP0001800_abnormal_humoral_immune1.57723174
35MP0002019_abnormal_tumor_incidence1.55020848
36MP0000716_abnormal_immune_system1.53416422
37MP0002420_abnormal_adaptive_immunity1.53410015
38MP0001929_abnormal_gametogenesis1.50590783
39MP0001819_abnormal_immune_cell1.50400436
40MP0003121_genomic_imprinting1.48570051
41MP0000653_abnormal_sex_gland1.41497941
42MP0002396_abnormal_hematopoietic_system1.39719872
43MP0002210_abnormal_sex_determination1.36058677
44MP0001697_abnormal_embryo_size1.34110391
45MP0002429_abnormal_blood_cell1.30293225
46MP0003786_premature_aging1.28562244
47MP0000490_abnormal_crypts_of1.28235228
48MP0002085_abnormal_embryonic_tissue1.27535378
49MP0002723_abnormal_immune_serum1.26568261
50MP0000313_abnormal_cell_death1.23334732
51MP0009785_altered_susceptibility_to1.19564148
52MP0002405_respiratory_system_inflammati1.18935683
53MP0001672_abnormal_embryogenesis/_devel1.17023527
54MP0005380_embryogenesis_phenotype1.17023527
55MP0002452_abnormal_antigen_presenting1.14311501
56MP0005000_abnormal_immune_tolerance1.11377898
57MP0001145_abnormal_male_reproductive1.05380588
58MP0002084_abnormal_developmental_patter1.05275057
59MP0003806_abnormal_nucleotide_metabolis1.04995204
60MP0002080_prenatal_lethality1.04244104
61MP0005387_immune_system_phenotype1.02483603
62MP0001790_abnormal_immune_system1.02483603
63MP0006082_CNS_inflammation0.99070169
64MP0005310_abnormal_salivary_gland0.99015589
65MP0001849_ear_inflammation0.96923673
66MP0002933_joint_inflammation0.96473162
67MP0000858_altered_metastatic_potential0.94880195
68MP0002086_abnormal_extraembryonic_tissu0.93479868
69MP0005023_abnormal_wound_healing0.93441907
70MP0005025_abnormal_response_to0.93398285
71MP0002006_tumorigenesis0.92854731
72MP0003984_embryonic_growth_retardation0.92755566
73MP0001873_stomach_inflammation0.91765301
74MP0010155_abnormal_intestine_physiology0.91743090
75MP0010234_abnormal_vibrissa_follicle0.91358180
76MP0005408_hypopigmentation0.89739787
77MP0002161_abnormal_fertility/fecundity0.88441962
78MP0002088_abnormal_embryonic_growth/wei0.88408746
79MP0001851_eye_inflammation0.87009960
80MP0001905_abnormal_dopamine_level0.86592999
81MP0004947_skin_inflammation0.79357501
82MP0002249_abnormal_larynx_morphology0.77686978
83MP0004264_abnormal_extraembryonic_tissu0.77037503
84MP0003448_altered_tumor_morphology0.76014990
85MP0004808_abnormal_hematopoietic_stem0.75904431
86MP0003890_abnormal_embryonic-extraembry0.75775070
87MP0005621_abnormal_cell_physiology0.74818264
88MP0003937_abnormal_limbs/digits/tail_de0.72426101
89MP0005076_abnormal_cell_differentiation0.71932263
90MP0001835_abnormal_antigen_presentation0.70237879
91MP0001845_abnormal_inflammatory_respons0.65477113
92MP0000477_abnormal_intestine_morphology0.64857141
93MP0000613_abnormal_salivary_gland0.63409990
94MP0004510_myositis0.62558236
95MP0005384_cellular_phenotype0.62410764
96MP0000579_abnormal_nail_morphology0.61882505
97MP0004381_abnormal_hair_follicle0.60809129
98MP0002638_abnormal_pupillary_reflex0.59455869
99MP0010307_abnormal_tumor_latency0.59183331
100MP0001915_intracranial_hemorrhage0.58100473

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)5.60475313
2Combined immunodeficiency (HP:0005387)5.54454420
3Male infertility (HP:0003251)5.08243178
4T lymphocytopenia (HP:0005403)4.53169242
5Birth length less than 3rd percentile (HP:0003561)4.45519782
6Abnormality of T cell number (HP:0011839)4.29679013
7Supernumerary spleens (HP:0009799)4.25764404
8Breast hypoplasia (HP:0003187)3.75617981
9Premature ovarian failure (HP:0008209)3.71049104
10Thyroiditis (HP:0100646)3.67124935
11Patellar aplasia (HP:0006443)3.59836182
12Type 2 muscle fiber atrophy (HP:0003554)3.53525227
13Abnormality of the labia minora (HP:0012880)3.50937859
14Muscle fiber atrophy (HP:0100295)3.47621065
15Recurrent bronchitis (HP:0002837)3.37563901
16Carpal bone hypoplasia (HP:0001498)3.29721443
17Depressed nasal tip (HP:0000437)3.28541006
18Aplasia/Hypoplasia of the patella (HP:0006498)3.27370865
19Secondary amenorrhea (HP:0000869)3.22942898
20Amniotic constriction ring (HP:0009775)3.09582561
21Abnormality of placental membranes (HP:0011409)3.09582561
22Facial hemangioma (HP:0000329)3.08356526
23Hypoplasia of the thymus (HP:0000778)3.07705540
24IgG deficiency (HP:0004315)2.96551984
25Abnormality of eosinophils (HP:0001879)2.96195468
26Recurrent cutaneous fungal infections (HP:0011370)2.95632646
27Chronic mucocutaneous candidiasis (HP:0002728)2.95632646
28Oral leukoplakia (HP:0002745)2.89882310
29Bronchitis (HP:0012387)2.88511061
30Chromsome breakage (HP:0040012)2.84015374
31Cerebral hypomyelination (HP:0006808)2.75271684
32Pulmonary fibrosis (HP:0002206)2.72624026
33Abnormality of T cells (HP:0002843)2.70522543
34Abnormality of the fingertips (HP:0001211)2.57883352
35Shawl scrotum (HP:0000049)2.57305461
36Leukocytosis (HP:0001974)2.55844802
37Abnormal lung lobation (HP:0002101)2.52320785
38Absent radius (HP:0003974)2.51853737
39Lymphopenia (HP:0001888)2.51642482
40Sparse lateral eyebrow (HP:0005338)2.51246029
41Chromosomal breakage induced by crosslinking agents (HP:0003221)2.50787068
42Colon cancer (HP:0003003)2.50417446
43Overlapping toe (HP:0001845)2.48558967
44Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.42659869
45Abnormality of abdominal situs (HP:0011620)2.42069302
46Abdominal situs inversus (HP:0003363)2.42069302
47Abnormality of cells of the lymphoid lineage (HP:0012140)2.38298044
48Chronic diarrhea (HP:0002028)2.38066322
49Ectopic kidney (HP:0000086)2.37861390
50Absent forearm bone (HP:0003953)2.35940569
51Aplasia involving forearm bones (HP:0009822)2.35940569
52Basal cell carcinoma (HP:0002671)2.31614285
53Amyotrophic lateral sclerosis (HP:0007354)2.30535284
54Aplasia/Hypoplasia involving the musculature (HP:0001460)2.27212055
55Stomatitis (HP:0010280)2.26152820
56Aplastic anemia (HP:0001915)2.25941195
57Flat capital femoral epiphysis (HP:0003370)2.24946470
58IgM deficiency (HP:0002850)2.23954380
59Optic neuritis (HP:0100653)2.20311961
60Retrobulbar optic neuritis (HP:0100654)2.20311961
61Rhabdomyosarcoma (HP:0002859)2.19160369
62Adrenal hypoplasia (HP:0000835)2.17596366
63Chronic bronchitis (HP:0004469)2.14931801
64Cleft eyelid (HP:0000625)2.14799259
65Cellular immunodeficiency (HP:0005374)2.12637828
66Breast aplasia (HP:0100783)2.11625652
67Recurrent fungal infections (HP:0002841)2.10483078
68Wrist flexion contracture (HP:0001239)2.10321302
69Abnormality of the preputium (HP:0100587)2.09761462
70Horseshoe kidney (HP:0000085)2.09366740
71Meckel diverticulum (HP:0002245)2.07341230
72Papillary thyroid carcinoma (HP:0002895)2.05921896
73Abnormality of chromosome stability (HP:0003220)2.05543247
74Microretrognathia (HP:0000308)2.05149948
75Medulloblastoma (HP:0002885)2.04617268
76CNS hypomyelination (HP:0003429)2.02499446
77Aplasia/Hypoplasia of the uvula (HP:0010293)1.97538039
78Squamous cell carcinoma (HP:0002860)1.97200413
79Agnosia (HP:0010524)1.96169164
80Aplasia/Hypoplasia of the breasts (HP:0010311)1.95238534
81Lip pit (HP:0100267)1.95090360
82Abnormality of the ileum (HP:0001549)1.94967380
83Hypoplasia of the capital femoral epiphysis (HP:0003090)1.94408993
84Cortical dysplasia (HP:0002539)1.93520271
85Oligodactyly (HP:0012165)1.93177933
86Rough bone trabeculation (HP:0100670)1.91354344
87Agammaglobulinemia (HP:0004432)1.91323066
88Autoimmune hemolytic anemia (HP:0001890)1.90850674
89Myelodysplasia (HP:0002863)1.90630390
90Neoplasm of the oral cavity (HP:0100649)1.89400615
91Granulocytopenia (HP:0001913)1.88416846
92Panhypogammaglobulinemia (HP:0003139)1.88308505
93Sandal gap (HP:0001852)1.88177397
94Bronchiectasis (HP:0002110)1.87878104
95Stillbirth (HP:0003826)1.86430802
96Lymphoma (HP:0002665)1.85648266
97Nonprogressive disorder (HP:0003680)1.84439970
98Capillary hemangiomas (HP:0005306)1.84100857
99Myositis (HP:0100614)1.82814702
100Popliteal pterygium (HP:0009756)1.82267368

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK43.94677285
2BUB13.87115045
3KDR3.19718043
4STK102.90438693
5CDC72.81764648
6TTK2.67140482
7TAOK32.58045876
8TESK22.53533031
9ERBB42.49881808
10MAP3K132.47874672
11TAOK12.38468937
12TXK2.27182844
13EEF2K2.23872430
14KSR22.22991216
15BRAF2.17066212
16NLK2.12706515
17MUSK2.09003207
18MAP4K12.06546963
19MAP3K62.06283122
20LATS22.04730501
21NME21.89297713
22ACVR1B1.84140819
23MOS1.71294845
24PLK11.70377073
25RAF11.69139267
26MAP3K91.63378916
27NEK21.62075622
28MELK1.60703825
29MAP3K81.44151896
30MAPKAPK31.44014574
31LATS11.43242049
32IKBKE1.38634544
33CHEK21.37860317
34SRPK11.35958459
35EIF2AK11.35957895
36JAK31.34953992
37NEK91.26474847
38AURKB1.20434642
39ZAP701.13585816
40WEE11.13399767
41TYK21.11069537
42MARK21.03085247
43STK38L1.03072695
44CDK81.00573487
45AURKA0.99472770
46ITK0.98496766
47RPS6KA40.97489467
48RPS6KB20.94394148
49ARAF0.89951181
50MAP3K100.89615737
51GRK60.84384363
52VRK10.82566748
53CDK90.78350822
54CHEK10.77091541
55BMPR20.76548635
56LCK0.72047856
57CDK40.71798206
58PRKD20.70208263
59DYRK20.68326944
60PLK30.67982664
61CDK70.67266081
62TLK10.60851254
63CSNK1G10.58372565
64PAK60.58093135
65ATR0.54753402
66BRSK10.53036523
67ATM0.52616017
68PRKCI0.48693527
69CDK20.47984389
70LRRK20.46933552
71STK30.45269696
72BRSK20.43053587
73PIM10.42995586
74FGFR40.42621225
75TYRO30.40554299
76CDK10.39947668
77EIF2AK30.39626292
78STK40.39073749
79KSR10.38145296
80STK240.35905156
81JAK10.34802679
82TSSK60.34005586
83MAPK130.33805071
84NUAK10.33733868
85TBK10.32065302
86MAPK110.31156209
87MAP3K120.29783116
88CSNK2A20.28833800
89TGFBR10.28043621
90HCK0.27922109
91CDK120.27580887
92CSNK1G30.27155482
93LYN0.25808549
94PAK40.24793395
95CSNK1E0.24410239
96ABL10.21715674
97STK380.21364750
98CSNK2A10.20525731
99PRKAA20.19737321
100PINK10.19567893

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030203.89012048
2DNA replication_Homo sapiens_hsa030303.66934402
3Mismatch repair_Homo sapiens_hsa034303.48893640
4Primary immunodeficiency_Homo sapiens_hsa053403.34355887
5RNA degradation_Homo sapiens_hsa030183.31195460
6Cell cycle_Homo sapiens_hsa041103.19361621
7Basal transcription factors_Homo sapiens_hsa030223.09155564
8Nucleotide excision repair_Homo sapiens_hsa034203.06334090
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.00246270
10Homologous recombination_Homo sapiens_hsa034402.77001526
11RNA transport_Homo sapiens_hsa030132.68066077
12Base excision repair_Homo sapiens_hsa034102.41617275
13Spliceosome_Homo sapiens_hsa030402.31287632
14Proteasome_Homo sapiens_hsa030502.28750081
15Pyrimidine metabolism_Homo sapiens_hsa002402.21606894
16p53 signaling pathway_Homo sapiens_hsa041152.02009574
17Fanconi anemia pathway_Homo sapiens_hsa034602.00867054
18Non-homologous end-joining_Homo sapiens_hsa034501.79142254
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59958168
20Ribosome_Homo sapiens_hsa030101.56823905
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.51178599
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50977159
23T cell receptor signaling pathway_Homo sapiens_hsa046601.44972253
24Oocyte meiosis_Homo sapiens_hsa041141.44783593
25Vitamin B6 metabolism_Homo sapiens_hsa007501.42094044
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.37327929
27mRNA surveillance pathway_Homo sapiens_hsa030151.30604072
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30181815
29Antigen processing and presentation_Homo sapiens_hsa046121.28884517
30One carbon pool by folate_Homo sapiens_hsa006701.25387596
31Hematopoietic cell lineage_Homo sapiens_hsa046401.24425824
32Epstein-Barr virus infection_Homo sapiens_hsa051691.21127457
33Measles_Homo sapiens_hsa051621.20332428
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17592739
35Circadian rhythm_Homo sapiens_hsa047101.16198664
36Pancreatic cancer_Homo sapiens_hsa052121.14491805
37Purine metabolism_Homo sapiens_hsa002301.14364518
38Colorectal cancer_Homo sapiens_hsa052101.12137892
39HTLV-I infection_Homo sapiens_hsa051661.11395048
40Other glycan degradation_Homo sapiens_hsa005111.07850502
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01445059
42Ovarian steroidogenesis_Homo sapiens_hsa049130.95760214
43Herpes simplex infection_Homo sapiens_hsa051680.92810732
44NF-kappa B signaling pathway_Homo sapiens_hsa040640.87187662
45Thyroid cancer_Homo sapiens_hsa052160.87099903
46Viral carcinogenesis_Homo sapiens_hsa052030.86882679
47TGF-beta signaling pathway_Homo sapiens_hsa043500.84932038
48Linoleic acid metabolism_Homo sapiens_hsa005910.82157421
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77301038
50Shigellosis_Homo sapiens_hsa051310.76975991
51Viral myocarditis_Homo sapiens_hsa054160.71384104
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68443643
53Adherens junction_Homo sapiens_hsa045200.63993040
54Sulfur relay system_Homo sapiens_hsa041220.63061719
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62707467
56MicroRNAs in cancer_Homo sapiens_hsa052060.62674003
57Jak-STAT signaling pathway_Homo sapiens_hsa046300.62035028
58Ether lipid metabolism_Homo sapiens_hsa005650.59204615
59Biosynthesis of amino acids_Homo sapiens_hsa012300.58886320
60Notch signaling pathway_Homo sapiens_hsa043300.58167355
61Apoptosis_Homo sapiens_hsa042100.57517028
62VEGF signaling pathway_Homo sapiens_hsa043700.53657056
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.51706560
64Hepatitis B_Homo sapiens_hsa051610.49903339
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47788013
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45853991
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.44749480
68Hippo signaling pathway_Homo sapiens_hsa043900.39938342
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39879571
70Prolactin signaling pathway_Homo sapiens_hsa049170.36700319
71Choline metabolism in cancer_Homo sapiens_hsa052310.36671702
72Graft-versus-host disease_Homo sapiens_hsa053320.35854062
73Small cell lung cancer_Homo sapiens_hsa052220.34583331
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32930568
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30772124
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30284082
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.30267259
78Allograft rejection_Homo sapiens_hsa053300.29692983
79Bladder cancer_Homo sapiens_hsa052190.28250590
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27453771
81Folate biosynthesis_Homo sapiens_hsa007900.26304893
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26264938
83Pathways in cancer_Homo sapiens_hsa052000.25033239
84Chemokine signaling pathway_Homo sapiens_hsa040620.24861608
85Acute myeloid leukemia_Homo sapiens_hsa052210.24331051
86Leishmaniasis_Homo sapiens_hsa051400.23503674
87Renal cell carcinoma_Homo sapiens_hsa052110.20264007
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19820707
89FoxO signaling pathway_Homo sapiens_hsa040680.19076951
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.17492315
91Osteoclast differentiation_Homo sapiens_hsa043800.17442397
92B cell receptor signaling pathway_Homo sapiens_hsa046620.17009373
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.15898629
94Autoimmune thyroid disease_Homo sapiens_hsa053200.15487364
95Ras signaling pathway_Homo sapiens_hsa040140.15076058
96Malaria_Homo sapiens_hsa051440.14874063
97Asthma_Homo sapiens_hsa053100.14504605
98GnRH signaling pathway_Homo sapiens_hsa049120.14439345
99Chronic myeloid leukemia_Homo sapiens_hsa052200.13869151
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12529540

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