RMDN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)6.35128292
2doxorubicin metabolic process (GO:0044598)6.35128292
3daunorubicin metabolic process (GO:0044597)6.35128292
4sulfur amino acid catabolic process (GO:0000098)5.73706994
5angiotensin maturation (GO:0002003)5.67302382
6coenzyme catabolic process (GO:0009109)5.63370208
7cellular modified amino acid catabolic process (GO:0042219)5.39558484
8NADH metabolic process (GO:0006734)5.24244225
9L-phenylalanine metabolic process (GO:0006558)5.18675218
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.18675218
11L-phenylalanine catabolic process (GO:0006559)5.14573665
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.14573665
13Golgi transport vesicle coating (GO:0048200)5.02231311
14COPI coating of Golgi vesicle (GO:0048205)5.02231311
15epoxygenase P450 pathway (GO:0019373)4.89377473
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.76523392
17cysteine metabolic process (GO:0006534)4.65131925
18hormone catabolic process (GO:0042447)4.63549701
19aromatic amino acid family catabolic process (GO:0009074)4.58913724
20glycosphingolipid catabolic process (GO:0046479)4.50998832
21lysine metabolic process (GO:0006553)4.43109316
22lysine catabolic process (GO:0006554)4.43109316
23aminoglycoside antibiotic metabolic process (GO:0030647)4.38549417
24serine family amino acid catabolic process (GO:0009071)4.36805443
25alpha-linolenic acid metabolic process (GO:0036109)4.34387702
26heme transport (GO:0015886)4.26646348
27biotin metabolic process (GO:0006768)4.23243285
28cofactor catabolic process (GO:0051187)4.21965114
29kynurenine metabolic process (GO:0070189)4.15876179
30glyoxylate metabolic process (GO:0046487)4.15018155
31glycolipid catabolic process (GO:0019377)4.13990967
32tryptophan catabolic process (GO:0006569)4.06633737
33indole-containing compound catabolic process (GO:0042436)4.06633737
34indolalkylamine catabolic process (GO:0046218)4.06633737
35urea cycle (GO:0000050)4.06263398
36urea metabolic process (GO:0019627)4.06263398
37drug metabolic process (GO:0017144)4.01516148
38bile acid biosynthetic process (GO:0006699)4.00524929
39glycine metabolic process (GO:0006544)3.99729444
40valine metabolic process (GO:0006573)3.93224905
41maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.90726013
42protein retention in ER lumen (GO:0006621)3.90068925
43fructose metabolic process (GO:0006000)3.89292085
44tryptophan metabolic process (GO:0006568)3.81531488
45cellular amino acid catabolic process (GO:0009063)3.78636272
46homocysteine metabolic process (GO:0050667)3.78427741
47high-density lipoprotein particle remodeling (GO:0034375)3.78013695
48very-low-density lipoprotein particle assembly (GO:0034379)3.76696392
49serine family amino acid metabolic process (GO:0009069)3.71232507
50alpha-amino acid catabolic process (GO:1901606)3.69837787
51proline biosynthetic process (GO:0006561)3.69544268
52fat-soluble vitamin biosynthetic process (GO:0042362)3.69058723
53negative regulation of fibrinolysis (GO:0051918)3.66165046
54nitrogen cycle metabolic process (GO:0071941)3.66005918
55amino-acid betaine metabolic process (GO:0006577)3.63010283
56response to dietary excess (GO:0002021)3.60331839
57fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.59162563
58regulation of triglyceride catabolic process (GO:0010896)3.56943961
59primary alcohol catabolic process (GO:0034310)3.55068361
60somite rostral/caudal axis specification (GO:0032525)3.50901721
61peptidyl-glutamic acid carboxylation (GO:0017187)3.49136746
62protein carboxylation (GO:0018214)3.49136746
63negative regulation of sterol transport (GO:0032372)3.48222184
64negative regulation of cholesterol transport (GO:0032375)3.48222184
65regulation of protein activation cascade (GO:2000257)3.47236857
66bile acid metabolic process (GO:0008206)3.45407986
67negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.44211187
68cellular response to thyroid hormone stimulus (GO:0097067)3.43667309
69maintenance of protein location in nucleus (GO:0051457)3.42914974
70complement activation, alternative pathway (GO:0006957)3.42401396
71flavonoid metabolic process (GO:0009812)3.40852842
72aromatic amino acid family metabolic process (GO:0009072)3.40529533
73ceramide catabolic process (GO:0046514)3.39622903
74acylglycerol homeostasis (GO:0055090)3.38647917
75triglyceride homeostasis (GO:0070328)3.38647917
76serine family amino acid biosynthetic process (GO:0009070)3.38495558
77negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.37727678
78cofactor transport (GO:0051181)3.36223191
79quinone metabolic process (GO:1901661)3.36136979
80plasma lipoprotein particle clearance (GO:0034381)3.35246891
81L-ascorbic acid metabolic process (GO:0019852)3.34858566
82regulation of cholesterol esterification (GO:0010872)3.34427363
83retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.33518393
84response to thyroid hormone (GO:0097066)3.33482555
85oligosaccharide catabolic process (GO:0009313)3.33274431
86negative regulation of telomerase activity (GO:0051974)3.32220233
87low-density lipoprotein particle clearance (GO:0034383)3.30713252
88reverse cholesterol transport (GO:0043691)3.27585914
89regulation of fibrinolysis (GO:0051917)3.27395701
90plasma lipoprotein particle assembly (GO:0034377)3.27328967
91glutamate metabolic process (GO:0006536)3.26074106
92plasma lipoprotein particle remodeling (GO:0034369)3.25994926
93protein-lipid complex remodeling (GO:0034368)3.25994926
94macromolecular complex remodeling (GO:0034367)3.25994926
95drug catabolic process (GO:0042737)3.25961106
96branched-chain amino acid catabolic process (GO:0009083)3.25827889
97regulation of complement activation (GO:0030449)3.25523354
98aspartate family amino acid catabolic process (GO:0009068)3.25364435
99acetyl-CoA metabolic process (GO:0006084)3.24017030
100amino acid import (GO:0043090)3.23935109
101barbed-end actin filament capping (GO:0051016)3.23320850
102carboxylic acid catabolic process (GO:0046395)3.19307309
103organic acid catabolic process (GO:0016054)3.19307309
104phospholipid efflux (GO:0033700)3.15797426
105protein-lipid complex assembly (GO:0065005)3.15381368
106glutamine family amino acid biosynthetic process (GO:0009084)3.14915845
107regulation of cholesterol homeostasis (GO:2000188)3.14364300
108proline metabolic process (GO:0006560)3.14105164
109ethanol oxidation (GO:0006069)3.12853368
110gluconeogenesis (GO:0006094)3.12635882
111xenobiotic catabolic process (GO:0042178)3.12280247
1122-oxoglutarate metabolic process (GO:0006103)3.11718487
113sodium ion export (GO:0071436)3.09474065
114protein localization to kinetochore (GO:0034501)3.09359610
115regulation of cholesterol storage (GO:0010885)3.08061369
116regulation of mammary gland epithelial cell proliferation (GO:0033599)3.07878372
117positive regulation of extracellular matrix organization (GO:1903055)3.07550634
118rRNA transcription (GO:0009303)3.07051987
119intestinal cholesterol absorption (GO:0030299)3.05151385
120short-chain fatty acid metabolic process (GO:0046459)3.04286630
121branched-chain amino acid metabolic process (GO:0009081)3.03446374
122cellular ketone body metabolic process (GO:0046950)3.01716205
123phenylpropanoid metabolic process (GO:0009698)3.00955876
124negative regulation of cell cycle G2/M phase transition (GO:1902750)3.00032271
125folic acid metabolic process (GO:0046655)2.99482553
126hexose biosynthetic process (GO:0019319)2.96529596
127imidazole-containing compound metabolic process (GO:0052803)2.96238071
128positive regulation of lipoprotein lipase activity (GO:0051006)2.95550715
129positive regulation of triglyceride lipase activity (GO:0061365)2.95550715
130apoptotic cell clearance (GO:0043277)2.94887730
131monosaccharide biosynthetic process (GO:0046364)2.93501884
132peroxisome fission (GO:0016559)2.92497960
133regulation of cholesterol metabolic process (GO:0090181)2.91967196
134protein localization to endosome (GO:0036010)2.88852004
135sphingolipid catabolic process (GO:0030149)2.88258572
136membrane lipid catabolic process (GO:0046466)2.87707317
137negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.85289212
138regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.84487131
139cellular copper ion homeostasis (GO:0006878)2.82895868
140adhesion of symbiont to host cell (GO:0044650)2.81846358
141virion attachment to host cell (GO:0019062)2.81846358
142GDP-mannose metabolic process (GO:0019673)2.81215137
143glucose 6-phosphate metabolic process (GO:0051156)2.79304719
144negative regulation of fatty acid biosynthetic process (GO:0045717)2.77490600
145surfactant homeostasis (GO:0043129)2.75958335
146cholesterol efflux (GO:0033344)2.72932548
147nucleoside diphosphate biosynthetic process (GO:0009133)2.72793043
148positive regulation of leukocyte degranulation (GO:0043302)2.72769685
149adhesion of symbiont to host (GO:0044406)2.72183787
150serine transport (GO:0032329)2.72001813
151lipopolysaccharide biosynthetic process (GO:0009103)2.70142712
152cell volume homeostasis (GO:0006884)2.68845214
153chaperone mediated protein folding requiring cofactor (GO:0051085)2.67768006
154regulation of cholesterol biosynthetic process (GO:0045540)2.66389655
155positive regulation of cholesterol efflux (GO:0010875)2.65644387
156peptide catabolic process (GO:0043171)2.64048925
157transcytosis (GO:0045056)2.61637561
158CDP-diacylglycerol metabolic process (GO:0046341)2.60146693
159regulation of inclusion body assembly (GO:0090083)2.58477805
160lipoprotein transport (GO:0042953)2.58303640
161regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.55659671
162negative regulation of inclusion body assembly (GO:0090084)2.54556298
163oxaloacetate metabolic process (GO:0006107)2.52681004
164glycolytic process (GO:0006096)2.52010379
165amyloid precursor protein catabolic process (GO:0042987)2.48087514
166L-serine transport (GO:0015825)2.47207382
167peptidyl-proline hydroxylation (GO:0019511)2.45608637
168negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.45242733
169tricarboxylic acid metabolic process (GO:0072350)2.43749137
1704-hydroxyproline metabolic process (GO:0019471)2.43526261
171positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.42578904
172vesicle coating (GO:0006901)2.42336497
173neutral amino acid transport (GO:0015804)2.42060664
174endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.41828389
175activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.41156888
176amino sugar catabolic process (GO:0046348)2.40196113
177L-amino acid import (GO:0043092)2.38247511
178endothelial cell chemotaxis (GO:0035767)2.36835712
179carnitine metabolic process (GO:0009437)2.35662866
180positive regulation of nuclease activity (GO:0032075)2.35342568
181endoplasmic reticulum unfolded protein response (GO:0030968)2.35329089
182transferrin transport (GO:0033572)2.34238768
183iron coordination entity transport (GO:1901678)2.32267358
184glycosylceramide metabolic process (GO:0006677)2.31608859
185vitamin transmembrane transport (GO:0035461)2.29133878

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.17783674
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.46619629
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.26329773
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.06470526
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.95222365
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.85519072
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.85519072
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.85519072
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.76484749
10LXR_22158963_ChIP-Seq_LIVER_Mouse3.29188084
11EGR1_23403033_ChIP-Seq_LIVER_Mouse3.01167490
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.95227484
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.66313199
14E2F7_22180533_ChIP-Seq_HELA_Human2.61755771
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.54254263
16NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.43490764
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.35944798
18CLOCK_20551151_ChIP-Seq_293T_Human2.34146279
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.31441554
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.16164799
21NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.12568164
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.06904877
23ELK3_25401928_ChIP-Seq_HUVEC_Human2.03363390
24VDR_21846776_ChIP-Seq_THP-1_Human2.01503595
25STAT3_1855785_ChIP-Seq_MESCs_Mouse2.01214120
26ZNF263_19887448_ChIP-Seq_K562_Human1.97388414
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.94628568
28SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.91436602
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.90975045
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.83776785
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81209945
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.79885632
33TCF3_18692474_ChIP-Seq_MEFs_Mouse1.78145041
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.77795668
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69806310
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.68838172
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.67833223
38SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.67242350
39TCF3_18692474_ChIP-Seq_MESCs_Mouse1.65160912
40ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.60387074
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.57971267
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57021088
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56392049
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55230235
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53894101
46NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.52365807
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46618918
48CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43077531
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42131683
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40782925
51GATA1_22025678_ChIP-Seq_K562_Human1.40384064
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40370777
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39145920
54KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38203139
55KDM2B_26808549_Chip-Seq_K562_Human1.35189351
56CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33610444
57PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31470063
58IRF1_19129219_ChIP-ChIP_H3396_Human1.30709116
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29915778
60CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29886201
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28258809
62OCT4_18692474_ChIP-Seq_MEFs_Mouse1.27224462
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26339524
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24718129
65EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24271555
66SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23421794
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22230007
68HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20647952
69EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20553183
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.20369382
71MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20271516
72BCL6_27268052_Chip-Seq_Bcells_Human1.19888461
73MYC_18555785_ChIP-Seq_MESCs_Mouse1.19840940
74VDR_24763502_ChIP-Seq_THP-1_Human1.19541885
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19363002
76POU5F1_16518401_ChIP-PET_MESCs_Mouse1.19021015
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.18791255
78UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18366568
79HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17050418
80TFEB_21752829_ChIP-Seq_HELA_Human1.16932718
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.16448978
82TP53_22127205_ChIP-Seq_IMR90_Human1.16391179
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15945937
84POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.15481695
85ETS1_21867929_ChIP-Seq_TH2_Mouse1.15318053
86CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15134413
87KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14724928
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14384928
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13588786
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12911293
91NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.12670856
92CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12411244
93KDM2B_26808549_Chip-Seq_DND41_Human1.12123521
94RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11326011
95POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10844720
96E2F4_17652178_ChIP-ChIP_JURKAT_Human1.10636520
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10313772
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09840041
99SOX2_18692474_ChIP-Seq_MEFs_Mouse1.09826164
100NANOG_18692474_ChIP-Seq_MEFs_Mouse1.09085910
101SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.08085417
102ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07278966
103CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07033910
104NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06202148
105P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05594089
106CDX2_20551321_ChIP-Seq_CACO-2_Human1.05444288
107MYC_19030024_ChIP-ChIP_MESCs_Mouse1.05419869
108TBX5_21415370_ChIP-Seq_HL-1_Mouse1.05039526
109RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04888436
110CREB1_26743006_Chip-Seq_LNCaP_Human1.04620016
111CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04482830
112PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03392013
113XRN2_22483619_ChIP-Seq_HELA_Human1.03156221
114AR_21909140_ChIP-Seq_LNCAP_Human1.02881649
115TCF7_22412390_ChIP-Seq_EML_Mouse1.02852628
116GATA1_19941826_ChIP-Seq_K562_Human1.02762966
117GATA1_19941827_ChIP-Seq_MEL_Mouse1.00517513
118FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.99922159
119NANOG_18692474_ChIP-Seq_MESCs_Mouse0.99892470
120STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99457808
121MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99330053
122NANOG_16518401_ChIP-PET_MESCs_Mouse0.99189021
123NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99041821
124CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98869948
125NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98849368
126SOX2_18692474_ChIP-Seq_MESCs_Mouse0.98628490
127E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95307793
128BCOR_27268052_Chip-Seq_Bcells_Human0.94579225
129LXR_22292898_ChIP-Seq_THP-1_Human0.93154526
130P68_20966046_ChIP-Seq_HELA_Human0.91750912
131PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91613371
132RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90500764
133ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90237765
134MYC_22102868_ChIP-Seq_BL_Human0.90084556
135JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.89426907
136TP63_19390658_ChIP-ChIP_HaCaT_Human0.88801515
137HNF4A_19822575_ChIP-Seq_HepG2_Human0.88509190
138RARB_24833708_ChIP-Seq_LIVER_Mouse0.88479184
139ELF1_20517297_ChIP-Seq_JURKAT_Human0.87989811
140KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87828107
141RARA_24833708_ChIP-Seq_LIVER_Mouse0.87795602
142GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.87637455
143MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.87383279
144SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87373216
145RACK7_27058665_Chip-Seq_MCF-7_Human0.84536358
146SMC4_20622854_ChIP-Seq_HELA_Human0.84276642
147FOXM1_23109430_ChIP-Seq_U2OS_Human0.83601929
148ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83220443
149ERG_21242973_ChIP-ChIP_JURKAT_Human0.83119092
150TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.82296942
151NCOR1_26117541_ChIP-Seq_K562_Human0.81276402
152NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.81202450
153E2F1_17053090_ChIP-ChIP_MCF-7_Human0.81053064
154STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80948086
155PHF8_20622854_ChIP-Seq_HELA_Human0.80847964
156SOX2_27498859_Chip-Seq_STOMACH_Mouse0.80183122
157TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.80150151
158CTCF_21964334_Chip-Seq_Bcells_Human0.79672256
159SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79605277
160ZFP281_18757296_ChIP-ChIP_E14_Mouse0.79018106
161MYC_19079543_ChIP-ChIP_MESCs_Mouse0.78862008
162NANOG_21062744_ChIP-ChIP_HESCs_Human0.76698217
163TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.75871959
164ATF3_27146783_Chip-Seq_COLON_Human0.75534450

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.06416496
2MP0005360_urolithiasis5.83828498
3MP0005058_abnormal_lysosome_morphology4.76377197
4MP0005365_abnormal_bile_salt4.52638247
5MP0005085_abnormal_gallbladder_physiolo4.42604391
6MP0008875_abnormal_xenobiotic_pharmacok4.11155816
7MP0003011_delayed_dark_adaptation4.05052356
8MP0003806_abnormal_nucleotide_metabolis3.74213312
9MP0002254_reproductive_system_inflammat3.37477900
10MP0004264_abnormal_extraembryonic_tissu3.10666254
11MP0010329_abnormal_lipoprotein_level2.95594621
12MP0009840_abnormal_foam_cell2.86505029
13MP0003252_abnormal_bile_duct2.69086101
14MP0008260_abnormal_autophagy2.68521076
15MP0003705_abnormal_hypodermis_morpholog2.66207148
16MP0005451_abnormal_body_composition2.35380431
17MP0006035_abnormal_mitochondrial_morpho2.31739668
18MP0003690_abnormal_glial_cell2.31500288
19MP0005332_abnormal_amino_acid2.30818047
20MP0001666_abnormal_nutrient_absorption2.20908644
21MP0000609_abnormal_liver_physiology2.07461954
22MP0005319_abnormal_enzyme/_coenzyme2.01060386
23MP0002332_abnormal_exercise_endurance1.97678240
24MP0004858_abnormal_nervous_system1.93426894
25MP0005083_abnormal_biliary_tract1.93197828
26MP0000343_altered_response_to1.90141261
27MP0003890_abnormal_embryonic-extraembry1.86182958
28MP0005075_abnormal_melanosome_morpholog1.85101750
29MP0003191_abnormal_cellular_cholesterol1.83568106
30MP0004019_abnormal_vitamin_homeostasis1.75500852
31MP0004043_abnormal_pH_regulation1.74687279
32MP0003656_abnormal_erythrocyte_physiolo1.73503434
33MP0003186_abnormal_redox_activity1.72077701
34MP0002118_abnormal_lipid_homeostasis1.69915570
35MP0005499_abnormal_olfactory_system1.68911307
36MP0005394_taste/olfaction_phenotype1.68911307
37MP0003172_abnormal_lysosome_physiology1.68882253
38MP0003453_abnormal_keratinocyte_physiol1.67889770
39MP0005409_darkened_coat_color1.67038419
40MP0006036_abnormal_mitochondrial_physio1.66890392
41MP0002877_abnormal_melanocyte_morpholog1.62541255
42MP0010234_abnormal_vibrissa_follicle1.62305968
43MP0005266_abnormal_metabolism1.59075881
44MP0006292_abnormal_olfactory_placode1.57685282
45MP0003303_peritoneal_inflammation1.51493200
46MP0005584_abnormal_enzyme/coenzyme_acti1.46920582
47MP0003879_abnormal_hair_cell1.44829717
48MP0003195_calcinosis1.44793986
49MP0000920_abnormal_myelination1.42984926
50MP0004957_abnormal_blastocyst_morpholog1.42919933
51MP0003183_abnormal_peptide_metabolism1.42364040
52MP0002735_abnormal_chemical_nociception1.40233404
53MP0005670_abnormal_white_adipose1.39790868
54MP0006082_CNS_inflammation1.35766084
55MP0003279_aneurysm1.32580983
56MP0005166_decreased_susceptibility_to1.32473722
57MP0009278_abnormal_bone_marrow1.31684356
58MP0002970_abnormal_white_adipose1.23102737
59MP0001853_heart_inflammation1.21733180
60MP0003634_abnormal_glial_cell1.21448003
61MP0001764_abnormal_homeostasis1.19859616
62MP0003566_abnormal_cell_adhesion1.18382511
63MP0000598_abnormal_liver_morphology1.18206707
64MP0009643_abnormal_urine_homeostasis1.17928488
65MP0005171_absent_coat_pigmentation1.17718315
66MP0008961_abnormal_basal_metabolism1.17336921
67MP0005501_abnormal_skin_physiology1.17258303
68MP0004859_abnormal_synaptic_plasticity1.12732005
69MP0005397_hematopoietic_system_phenotyp1.12180404
70MP0001545_abnormal_hematopoietic_system1.12180404
71MP0005376_homeostasis/metabolism_phenot1.10863854
72MP0005076_abnormal_cell_differentiation1.10017990
73MP0000747_muscle_weakness1.09298823
74MP0002148_abnormal_hypersensitivity_rea1.08640440
75MP0010352_gastrointestinal_tract_polyps1.07170738
76MP0008874_decreased_physiological_sensi1.05471193
77MP0008872_abnormal_physiological_respon0.98411713
78MP0005375_adipose_tissue_phenotype0.98241136
79MP0000858_altered_metastatic_potential0.96764837
80MP0002090_abnormal_vision0.93423657
81MP0003091_abnormal_cell_migration0.90891805
82MP0005380_embryogenesis_phenotype0.89845655
83MP0001672_abnormal_embryogenesis/_devel0.89845655
84MP0002088_abnormal_embryonic_growth/wei0.87462829
85MP0005636_abnormal_mineral_homeostasis0.86169475
86MP0003984_embryonic_growth_retardation0.85755585
87MP0002653_abnormal_ependyma_morphology0.85553094
88MP0004947_skin_inflammation0.84496963
89MP0002971_abnormal_brown_adipose0.83959751
90MP0000003_abnormal_adipose_tissue0.83515379
91MP0009115_abnormal_fat_cell0.83495115
92MP0004185_abnormal_adipocyte_glucose0.82990338
93MP0002078_abnormal_glucose_homeostasis0.81196926
94MP0004270_analgesia0.80504995
95MP0001881_abnormal_mammary_gland0.80422824
96MP0003868_abnormal_feces_composition0.78422955
97MP0004233_abnormal_muscle_weight0.77561648
98MP0001958_emphysema0.77151518
99MP0009765_abnormal_xenobiotic_induced0.76449147
100MP0004147_increased_porphyrin_level0.75526998
101MP0001502_abnormal_circadian_rhythm0.75163643
102MP0002098_abnormal_vibrissa_morphology0.74901152
103MP0005535_abnormal_body_temperature0.74513079
104MP0003638_abnormal_response/metabolism_0.74170136
105MP0000249_abnormal_blood_vessel0.74050084
106MP0005023_abnormal_wound_healing0.73677723
107MP0003122_maternal_imprinting0.73546230
108MP0005621_abnormal_cell_physiology0.72098208
109MP0000358_abnormal_cell_content/0.71149562
110MP0002269_muscular_atrophy0.70875060
111MP0008057_abnormal_DNA_replication0.70270830
112MP0005448_abnormal_energy_balance0.69810665
113MP0003300_gastrointestinal_ulcer0.69703115
114MP0000604_amyloidosis0.69481437
115MP0003448_altered_tumor_morphology0.69017780
116MP0009763_increased_sensitivity_to0.68588258
117MP0001727_abnormal_embryo_implantation0.68095115
118MP0005423_abnormal_somatic_nervous0.68093271
119MP0009764_decreased_sensitivity_to0.67427530
120MP0002419_abnormal_innate_immunity0.67263720
121MP0003283_abnormal_digestive_organ0.66400909
122MP0000678_abnormal_parathyroid_gland0.65387124
123MP0005666_abnormal_adipose_tissue0.65033903
124MP0003436_decreased_susceptibility_to0.64884292
125MP0001849_ear_inflammation0.64322759
126MP0002086_abnormal_extraembryonic_tissu0.64017390
127MP0005165_increased_susceptibility_to0.63789712
128MP0002998_abnormal_bone_remodeling0.62894644
129MP0001756_abnormal_urination0.61879328
130MP0004782_abnormal_surfactant_physiolog0.61758531
131MP0008469_abnormal_protein_level0.61465279
132MP0005257_abnormal_intraocular_pressure0.60776668
133MP0002127_abnormal_cardiovascular_syste0.59939809
134MP0009642_abnormal_blood_homeostasis0.58859109
135MP0005452_abnormal_adipose_tissue0.57190107
136MP0008873_increased_physiological_sensi0.55520983
137MP0002876_abnormal_thyroid_physiology0.54459294
138MP0003123_paternal_imprinting0.54041149
139MP0002132_abnormal_respiratory_system0.53863788
140MP0001730_embryonic_growth_arrest0.52800586
141MP0002822_catalepsy0.51954766
142MP0005334_abnormal_fat_pad0.51947909
143MP0005647_abnormal_sex_gland0.51105407
144MP0002092_abnormal_eye_morphology0.50945967
145MP0002796_impaired_skin_barrier0.50145422
146MP0003329_amyloid_beta_deposits0.49750566
147MP0002138_abnormal_hepatobiliary_system0.49654369
148MP0000350_abnormal_cell_proliferation0.49433161
149MP0003718_maternal_effect0.47382113
150MP0003075_altered_response_to0.47288092
151MP0005248_abnormal_Harderian_gland0.44724476
152MP0008770_decreased_survivor_rate0.44019982
153MP0005167_abnormal_blood-brain_barrier0.41505640
154MP0009672_abnormal_birth_weight0.41387764

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)5.89456869
2Abnormality of liposaccharide metabolism (HP:0010968)4.85754778
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.85754778
4Abnormality of glycolipid metabolism (HP:0010969)4.85754778
5Abnormality of the lower motor neuron (HP:0002366)4.63069655
6Multiple enchondromatosis (HP:0005701)4.61809895
7Intrahepatic cholestasis (HP:0001406)4.60207048
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.53679244
9Hyperglycinuria (HP:0003108)4.52160499
10Systemic lupus erythematosus (HP:0002725)4.32805923
11Bilateral microphthalmos (HP:0007633)4.26257707
12Xanthomatosis (HP:0000991)4.26245324
13Hypobetalipoproteinemia (HP:0003563)4.05287368
14Abnormality of monocarboxylic acid metabolism (HP:0010996)4.02657106
15Deep venous thrombosis (HP:0002625)3.91206659
16Abnormality of the intrinsic pathway (HP:0010989)3.88479118
17Abnormality of glycine metabolism (HP:0010895)3.88321937
18Abnormality of serine family amino acid metabolism (HP:0010894)3.88321937
19Neurofibrillary tangles (HP:0002185)3.79852308
20Hepatoblastoma (HP:0002884)3.79693029
21Hyperinsulinemic hypoglycemia (HP:0000825)3.76154100
22Hyperammonemia (HP:0001987)3.75866065
23Increased cerebral lipofuscin (HP:0011813)3.74034967
24Mutism (HP:0002300)3.57539195
25Abnormal cartilage morphology (HP:0002763)3.56756497
26Vacuolated lymphocytes (HP:0001922)3.49895862
27Ragged-red muscle fibers (HP:0003200)3.48812288
28Tetraplegia (HP:0002445)3.33165687
29Gout (HP:0001997)3.32805050
30Hyperglycinemia (HP:0002154)3.32639125
31Axonal loss (HP:0003447)3.27411653
32Hypolipoproteinemia (HP:0010981)3.26310872
33Skin nodule (HP:0200036)3.25917869
34Loss of speech (HP:0002371)3.24293975
35Ketosis (HP:0001946)3.22487193
36Dysostosis multiplex (HP:0000943)3.17355970
37Hyperlipoproteinemia (HP:0010980)3.17290150
38Prolonged partial thromboplastin time (HP:0003645)3.14101013
39Neuronal loss in central nervous system (HP:0002529)3.13352470
40Malnutrition (HP:0004395)3.08979532
41Cerebral inclusion bodies (HP:0100314)3.07839430
42Hypoalphalipoproteinemia (HP:0003233)2.99265173
43Abnormality of glutamine family amino acid metabolism (HP:0010902)2.98748309
44Abnormality of sulfur amino acid metabolism (HP:0004339)2.93873538
45Increased neuronal autofluorescent lipopigment (HP:0002074)2.91905952
46Hypoglycemic coma (HP:0001325)2.90922540
47Ketoacidosis (HP:0001993)2.85347810
48Hemorrhage of the eye (HP:0011885)2.83686003
49Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.81195390
50Distal upper limb amyotrophy (HP:0007149)2.77466598
51Upper limb amyotrophy (HP:0009129)2.77466598
52Complement deficiency (HP:0004431)2.74380980
53Ependymoma (HP:0002888)2.72231477
54Nuclear cataract (HP:0100018)2.71155844
55Supranuclear gaze palsy (HP:0000605)2.69101306
56Upper motor neuron abnormality (HP:0002127)2.68221490
57Increased serum pyruvate (HP:0003542)2.67429789
58Abnormality of glycolysis (HP:0004366)2.67429789
59Epidermoid cyst (HP:0200040)2.67229217
60Abnormality of aspartate family amino acid metabolism (HP:0010899)2.66728635
61Hyperbilirubinemia (HP:0002904)2.64294097
62Diminished motivation (HP:0000745)2.62699641
63Hypercholesterolemia (HP:0003124)2.58678168
64Apathy (HP:0000741)2.57162706
65Metabolic acidosis (HP:0001942)2.57112389
66Abnormality of polysaccharide metabolism (HP:0011012)2.56213250
67Abnormality of glycosaminoglycan metabolism (HP:0004371)2.56213250
68Abnormality of mucopolysaccharide metabolism (HP:0011020)2.56213250
69Tetraparesis (HP:0002273)2.54467099
70Vertebral compression fractures (HP:0002953)2.53611105
71Abnormality of methionine metabolism (HP:0010901)2.50866905
72Steatorrhea (HP:0002570)2.49274322
73Reduced antithrombin III activity (HP:0001976)2.46460653
74J-shaped sella turcica (HP:0002680)2.45940640
75Abnormality of the heme biosynthetic pathway (HP:0010472)2.44934447
76Status epilepticus (HP:0002133)2.44926389
77Glomerulonephritis (HP:0000099)2.44335991
78Reticulocytosis (HP:0001923)2.43792738
79Mucopolysacchariduria (HP:0008155)2.43141533
80Urinary glycosaminoglycan excretion (HP:0003541)2.43141533
81Neoplasm of striated muscle (HP:0009728)2.43067227
82Fat malabsorption (HP:0002630)2.40699023
83Rhabdomyosarcoma (HP:0002859)2.39915774
84Irritability (HP:0000737)2.39731230
85Abnormality of fatty-acid metabolism (HP:0004359)2.38481191
86Abnormality of the periventricular white matter (HP:0002518)2.38440467
87Spastic tetraparesis (HP:0001285)2.38065032
88Abnormality of purine metabolism (HP:0004352)2.36593268
89Male infertility (HP:0003251)2.35600207
90Abnormality of nucleobase metabolism (HP:0010932)2.35036367
91Cholelithiasis (HP:0001081)2.35028935
92Spastic diplegia (HP:0001264)2.34253943
93Dicarboxylic aciduria (HP:0003215)2.33973743
94Abnormality of dicarboxylic acid metabolism (HP:0010995)2.33973743
95Joint hemorrhage (HP:0005261)2.33508102
96Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.32840339
97Abnormality of pyrimidine metabolism (HP:0004353)2.31922567
98Prolonged neonatal jaundice (HP:0006579)2.30932267
99Testicular atrophy (HP:0000029)2.30040187
100Interstitial pulmonary disease (HP:0006530)2.29066443
101Abnormal gallbladder morphology (HP:0012437)2.27620435
102Myocardial infarction (HP:0001658)2.27450005
103Hypochromic anemia (HP:0001931)2.26769949
104Rib fusion (HP:0000902)2.25653796
105Hyperventilation (HP:0002883)2.21641160
106Abnormality of the common coagulation pathway (HP:0010990)2.20491524
107Growth hormone excess (HP:0000845)2.19192972
108Lethargy (HP:0001254)2.17334284
109Acanthocytosis (HP:0001927)2.17189638
110Abnormality of the Achilles tendon (HP:0005109)2.16590015
111Ankle clonus (HP:0011448)2.14849653
112Horizontal nystagmus (HP:0000666)2.14364486
113Impaired proprioception (HP:0010831)2.12609179
114Thin bony cortex (HP:0002753)2.12170773
115Abnormality of complement system (HP:0005339)2.11521212
116Abnormality of serum amino acid levels (HP:0003112)2.11485163
117Limb hypertonia (HP:0002509)2.11445641
118Nonimmune hydrops fetalis (HP:0001790)2.09881868
119Vaginal fistula (HP:0004320)2.09756333
120Dementia (HP:0000726)2.09626521
121Hydroxyprolinuria (HP:0003080)2.08806767
122Abnormality of proline metabolism (HP:0010907)2.08806767
123Peripheral hypomyelination (HP:0007182)2.08596418
124Hyperparathyroidism (HP:0000843)2.08173374
125Vomiting (HP:0002013)2.06667062
126Amyotrophic lateral sclerosis (HP:0007354)2.06643591
127Progressive muscle weakness (HP:0003323)2.05742490
128Hypoplasia of the fovea (HP:0007750)2.05233289
129Aplasia/Hypoplasia of the fovea (HP:0008060)2.05233289
130Abnormality of transition element cation homeostasis (HP:0011030)2.03892348
131Abnormality of the gallbladder (HP:0005264)2.03808326
132Delayed CNS myelination (HP:0002188)2.03377206
133Pseudobulbar signs (HP:0002200)2.02533242
134Polycythemia (HP:0001901)2.01950384
135Nausea (HP:0002018)2.01892769
136Cholecystitis (HP:0001082)2.01440413
137Abnormal gallbladder physiology (HP:0012438)2.01440413
138Confusion (HP:0001289)1.99024956
139Hyperuricemia (HP:0002149)1.98852811
140Increased purine levels (HP:0004368)1.98852811
141Abnormality of iron homeostasis (HP:0011031)1.98766772
142Hypokinesia (HP:0002375)1.98423298
143Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97589386
144Increased serum ferritin (HP:0003281)1.96983155
145Global brain atrophy (HP:0002283)1.96783518
146Poikilocytosis (HP:0004447)1.96124680
147Abnormality of the salivary glands (HP:0010286)1.96011842
148Hepatocellular carcinoma (HP:0001402)1.95873067
149Hand muscle atrophy (HP:0009130)1.95141527
150Bile duct proliferation (HP:0001408)1.91570282
151Abnormal biliary tract physiology (HP:0012439)1.91570282
152Insomnia (HP:0100785)1.91078197
153Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.89991170
154Conjugated hyperbilirubinemia (HP:0002908)1.89490520
155Bone pain (HP:0002653)1.87690368
156Abnormal trabecular bone morphology (HP:0100671)1.87479744
157Annular pancreas (HP:0001734)1.86921839
158Elevated alkaline phosphatase (HP:0003155)1.86564370
159Multiple lipomas (HP:0001012)1.85855152
160Fused cervical vertebrae (HP:0002949)1.83587911
161Abnormal neuron morphology (HP:0012757)1.81982230
162Abnormality of the motor neurons (HP:0002450)1.81982230
163Rough bone trabeculation (HP:0100670)1.81855278
164Delusions (HP:0000746)1.81555558
165Subcapsular cataract (HP:0000523)1.81385574
166Achilles tendon contracture (HP:0001771)1.80835633
167Athetosis (HP:0002305)1.79177859
168Disinhibition (HP:0000734)1.78884344
169Urinary incontinence (HP:0000020)1.78617535
170Personality changes (HP:0000751)1.78278570
171Abnormal enzyme/coenzyme activity (HP:0012379)1.75547056
172Hammertoe (HP:0001765)1.73615697
173Rapidly progressive (HP:0003678)1.73012706
174Abnormality of alkaline phosphatase activity (HP:0004379)1.72835193
175Distal sensory impairment (HP:0002936)1.72703464
176Hypertensive crisis (HP:0100735)1.70931133
177Abnormality of the costochondral junction (HP:0000919)1.67585652

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.62007881
2ERN16.04109680
3GRK54.65369096
4GRK64.10976586
5PRPF4B3.26238007
6BCKDK3.05626696
7GRK13.03775296
8TRIM282.90438368
9TESK12.79763910
10PIM22.78003693
11TSSK62.49516732
12TTK2.41331960
13MAPK152.39926121
14IRAK32.39830139
15CSF1R2.33372173
16ADRBK22.19910256
17TIE12.15438068
18MAPK72.15384959
19MAP2K42.05024529
20TGFBR22.04914759
21TYRO32.03032283
22NME21.87787975
23STK101.77755664
24MOS1.75416444
25MATK1.73187301
26EPHA21.70538318
27MAP3K31.64689589
28TBK11.62506593
29MAP3K131.58783323
30SIK11.56554391
31WNK11.49305781
32LMTK21.46938158
33GRK71.45316426
34NTRK11.36335826
35AKT31.36284740
36MAP3K101.35275934
37PRKG21.33204522
38TRIB31.27269617
39DDR21.26859999
40EPHA41.25351894
41CDK61.24699718
42ICK1.20050329
43RIPK11.18502934
44NEK11.16357890
45CAMK41.15491938
46LIMK11.14101984
47MAP3K11.02036724
48NEK61.00184421
49PDPK10.99341918
50MAPKAPK30.98408073
51PAK40.93589309
52FGFR30.92968369
53PAK60.92639946
54CDK70.92278122
55MST1R0.92058555
56MAP3K90.90160181
57PLK10.89935469
58MAP2K60.87821365
59SIK30.87744891
60FER0.86998048
61PDGFRA0.86015697
62PDK30.82858198
63PDK40.82858198
64MAPK120.82001371
65EPHB10.81920804
66CAMK2G0.81866099
67CHEK20.79117453
68MAP3K20.78680285
69MAP3K70.77886693
70FGFR40.76487963
71ERBB40.75000666
72EPHA30.72671459
73NEK20.70318262
74AKT20.70179767
75BUB10.70168838
76CDK40.70168763
77ADRBK10.70053568
78CSK0.68827835
79BRAF0.66932552
80LATS20.65795318
81HIPK20.65064624
82ALK0.64111956
83MARK20.61144553
84DAPK30.59345973
85KDR0.57890773
86ABL20.56909710
87FLT30.55391719
88DAPK10.55181443
89PINK10.54829316
90CDK11A0.54541616
91NEK90.53618476
92PKN20.53267179
93MTOR0.52927237
94RAF10.52189403
95PRKD20.51912735
96PDK20.51862894
97CDK140.51826785
98PTK20.51815882
99MAP3K50.50554090
100JAK20.50428403
101CDK150.49807993
102PRKAA10.49734372
103PRKACG0.49146859
104PIM10.48715331
105CAMKK10.47775793
106MAPK110.47405094
107CCNB10.47092968
108CDK180.46744856
109DAPK20.46716834
110AURKA0.44380909
111CHEK10.44294528
112ERBB20.44161462
113PRKCG0.44148765
114EIF2AK10.44110659
115EEF2K0.43303292
116CAMK2B0.43240137
117PRKCI0.43035010
118MET0.42259217
119CDK90.40532910
120IRAK20.39681720
121STK380.39652098
122MAPK100.38514147
123KSR20.38330067
124SCYL20.38301673
125CDC42BPA0.37748355
126TYK20.37542451
127RPS6KA20.37103974
128PRKD10.37044704
129CAMK1D0.36492791
130EPHB20.35790687
131IGF1R0.35769163
132PDK10.34913450
133ARAF0.32814008
134TAOK10.32595429
135GSK3A0.30946246
136MAPK40.30901916
137CSNK1E0.30661738
138STK160.30554548
139ACVR1B0.28913039
140CDK20.28143863
141MAP3K80.27426642
142BMX0.27405725
143PRKAA20.27230878
144PRKCD0.25690279
145PBK0.25388112
146EIF2AK20.24468574
147TAOK30.23947619
148WEE10.21743168
149ITK0.20153794
150RPS6KA30.18931894
151MAP3K110.18585466
152INSRR0.18575561
153PAK10.18574733
154DYRK1B0.18250369
155TESK20.17946797
156TAOK20.17390225

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.80522335
2Vitamin B6 metabolism_Homo sapiens_hsa007503.50478627
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.44275998
4Nitrogen metabolism_Homo sapiens_hsa009103.04769853
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.86188013
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.70913244
7Arginine biosynthesis_Homo sapiens_hsa002202.64327293
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.64218145
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62564589
10Tryptophan metabolism_Homo sapiens_hsa003802.55382125
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.52141520
12Lysosome_Homo sapiens_hsa041422.48920768
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.28438788
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.26015531
15Fatty acid degradation_Homo sapiens_hsa000712.24288664
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.16122434
17Butanoate metabolism_Homo sapiens_hsa006501.99905530
18Fructose and mannose metabolism_Homo sapiens_hsa000511.99545164
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.96993034
20Complement and coagulation cascades_Homo sapiens_hsa046101.95968908
21Propanoate metabolism_Homo sapiens_hsa006401.91811328
22PPAR signaling pathway_Homo sapiens_hsa033201.90119530
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.85511152
24Peroxisome_Homo sapiens_hsa041461.81353583
25Caffeine metabolism_Homo sapiens_hsa002321.77166299
26Folate biosynthesis_Homo sapiens_hsa007901.76704041
27Carbon metabolism_Homo sapiens_hsa012001.71314616
28Chemical carcinogenesis_Homo sapiens_hsa052041.69532860
29Selenocompound metabolism_Homo sapiens_hsa004501.66536645
30Fatty acid metabolism_Homo sapiens_hsa012121.64007311
31Vibrio cholerae infection_Homo sapiens_hsa051101.63735396
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.61359017
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.59722811
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.58507545
35Biosynthesis of amino acids_Homo sapiens_hsa012301.53678491
36Fat digestion and absorption_Homo sapiens_hsa049751.52440434
37Sulfur relay system_Homo sapiens_hsa041221.51033569
38Pyruvate metabolism_Homo sapiens_hsa006201.50694144
39Galactose metabolism_Homo sapiens_hsa000521.49501361
40beta-Alanine metabolism_Homo sapiens_hsa004101.47343404
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45273021
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.44881268
43Bile secretion_Homo sapiens_hsa049761.41153573
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37303904
45Synaptic vesicle cycle_Homo sapiens_hsa047211.32036662
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.30560574
47Histidine metabolism_Homo sapiens_hsa003401.27366417
48Retinol metabolism_Homo sapiens_hsa008301.26358995
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20233057
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.18828955
51Starch and sucrose metabolism_Homo sapiens_hsa005001.17684767
52Pentose phosphate pathway_Homo sapiens_hsa000301.15912724
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.14361611
54Sulfur metabolism_Homo sapiens_hsa009201.08793290
55Glycerolipid metabolism_Homo sapiens_hsa005611.07181331
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06805277
57ABC transporters_Homo sapiens_hsa020101.05608556
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04022166
59Phenylalanine metabolism_Homo sapiens_hsa003601.02810410
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00836967
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99389061
62One carbon pool by folate_Homo sapiens_hsa006700.98164222
63Sphingolipid metabolism_Homo sapiens_hsa006000.98137071
64Tyrosine metabolism_Homo sapiens_hsa003500.91478183
65Vitamin digestion and absorption_Homo sapiens_hsa049770.87573947
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85695665
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83817142
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82249780
69N-Glycan biosynthesis_Homo sapiens_hsa005100.80284003
70Linoleic acid metabolism_Homo sapiens_hsa005910.80230914
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.78849512
72Arginine and proline metabolism_Homo sapiens_hsa003300.77821420
73Fatty acid elongation_Homo sapiens_hsa000620.77463233
74Staphylococcus aureus infection_Homo sapiens_hsa051500.75612694
75Hepatitis C_Homo sapiens_hsa051600.74557652
76Glutathione metabolism_Homo sapiens_hsa004800.71402935
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70110390
78Collecting duct acid secretion_Homo sapiens_hsa049660.66493854
79Arachidonic acid metabolism_Homo sapiens_hsa005900.65964882
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65729541
81Bladder cancer_Homo sapiens_hsa052190.62338409
82Lysine degradation_Homo sapiens_hsa003100.62010773
83Pertussis_Homo sapiens_hsa051330.59265954
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58390852
85Metabolic pathways_Homo sapiens_hsa011000.58032073
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.57057021
87Fatty acid biosynthesis_Homo sapiens_hsa000610.55180133
88Phagosome_Homo sapiens_hsa041450.54424946
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54402871
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50192860
91Endocytosis_Homo sapiens_hsa041440.44719840
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44163812
93Salmonella infection_Homo sapiens_hsa051320.42730136
94Rheumatoid arthritis_Homo sapiens_hsa053230.42615793
95Steroid biosynthesis_Homo sapiens_hsa001000.40323242
96HIF-1 signaling pathway_Homo sapiens_hsa040660.39898769
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.39389871
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.35213563
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33818453
100TNF signaling pathway_Homo sapiens_hsa046680.33048283
101Apoptosis_Homo sapiens_hsa042100.32447408
102Estrogen signaling pathway_Homo sapiens_hsa049150.30681456
103AMPK signaling pathway_Homo sapiens_hsa041520.29590798
104Renal cell carcinoma_Homo sapiens_hsa052110.28437329
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27891439
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26509518
107mTOR signaling pathway_Homo sapiens_hsa041500.26062672
108Renin-angiotensin system_Homo sapiens_hsa046140.25335274
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24742178
110Insulin signaling pathway_Homo sapiens_hsa049100.24208072
111Legionellosis_Homo sapiens_hsa051340.21469445
112Insulin resistance_Homo sapiens_hsa049310.20977573
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.19513126
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.17552901
115Thyroid cancer_Homo sapiens_hsa052160.14634251
116Regulation of autophagy_Homo sapiens_hsa041400.13919715
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11181395
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.11142309
119Prion diseases_Homo sapiens_hsa050200.10629613
120Ovarian steroidogenesis_Homo sapiens_hsa049130.08691687
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.07599105
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.01120738
123Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0715949
124Mineral absorption_Homo sapiens_hsa04978-0.0568914
125Protein digestion and absorption_Homo sapiens_hsa04974-0.0559880
126Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0525529
127RNA transport_Homo sapiens_hsa03013-0.0519435
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0284420
129Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0021182

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