RMI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RMI1 is a component of protein complexes that limit DNA crossover formation via the dissolution of double Holliday junctions (Raynard et al., 2006 [PubMed 16595695]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.74650462
2DNA replication checkpoint (GO:0000076)4.52514119
3protein localization to kinetochore (GO:0034501)4.50142044
4attachment of spindle microtubules to kinetochore (GO:0008608)4.38268496
5protein localization to chromosome, centromeric region (GO:0071459)4.36887074
6DNA ligation (GO:0006266)4.33853536
7establishment of integrated proviral latency (GO:0075713)4.33213271
8DNA double-strand break processing (GO:0000729)4.29721199
9metaphase plate congression (GO:0051310)4.21583400
10DNA strand elongation involved in DNA replication (GO:0006271)4.16563750
11DNA replication initiation (GO:0006270)4.16304950
12meiotic chromosome segregation (GO:0045132)4.16212687
13mitotic sister chromatid cohesion (GO:0007064)4.15150636
14mitotic chromosome condensation (GO:0007076)4.07165799
15DNA unwinding involved in DNA replication (GO:0006268)4.07063780
16chromatin remodeling at centromere (GO:0031055)4.05924655
17CENP-A containing nucleosome assembly (GO:0034080)4.03468960
18DNA strand elongation (GO:0022616)3.97803957
19establishment of chromosome localization (GO:0051303)3.89782525
20kinetochore organization (GO:0051383)3.87619023
21mitotic nuclear envelope disassembly (GO:0007077)3.86325815
22replication fork processing (GO:0031297)3.85992105
23double-strand break repair via nonhomologous end joining (GO:0006303)3.85762514
24non-recombinational repair (GO:0000726)3.85762514
25negative regulation of DNA-dependent DNA replication (GO:2000104)3.79394595
26folic acid-containing compound biosynthetic process (GO:0009396)3.77496115
27telomere maintenance via semi-conservative replication (GO:0032201)3.75814296
28telomere maintenance via recombination (GO:0000722)3.75185552
29nuclear pore complex assembly (GO:0051292)3.74877539
30DNA replication-independent nucleosome organization (GO:0034724)3.73704802
31DNA replication-independent nucleosome assembly (GO:0006336)3.73704802
32regulation of DNA endoreduplication (GO:0032875)3.73524143
33regulation of spindle organization (GO:0090224)3.71485625
34nuclear pore organization (GO:0006999)3.71366742
35histone exchange (GO:0043486)3.68823144
36mitotic recombination (GO:0006312)3.58615200
37mitotic sister chromatid segregation (GO:0000070)3.55838589
38membrane disassembly (GO:0030397)3.54466808
39nuclear envelope disassembly (GO:0051081)3.54466808
40positive regulation of chromosome segregation (GO:0051984)3.52926614
41regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.50758604
42maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.44262657
43positive regulation of mitotic sister chromatid separation (GO:1901970)3.44165190
44positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.44165190
45positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.44165190
46mitotic G2/M transition checkpoint (GO:0044818)3.42846804
47establishment of viral latency (GO:0019043)3.41615684
48regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.40802291
49purine nucleobase biosynthetic process (GO:0009113)3.37970244
50DNA replication-dependent nucleosome organization (GO:0034723)3.37015023
51DNA replication-dependent nucleosome assembly (GO:0006335)3.37015023
52microtubule depolymerization (GO:0007019)3.36862448
53regulation of double-strand break repair via homologous recombination (GO:0010569)3.36660409
54protein localization to chromosome (GO:0034502)3.36590847
55nucleobase biosynthetic process (GO:0046112)3.32690553
56regulation of RNA export from nucleus (GO:0046831)3.32253825
57kinetochore assembly (GO:0051382)3.29974570
58IMP biosynthetic process (GO:0006188)3.28779302
59piRNA metabolic process (GO:0034587)3.28385224
60male meiosis (GO:0007140)3.27999220
61negative regulation of DNA recombination (GO:0045910)3.27822156
62proteasome assembly (GO:0043248)3.27525643
63DNA topological change (GO:0006265)3.25358201
64protein K6-linked ubiquitination (GO:0085020)3.23812632
65regulation of sister chromatid cohesion (GO:0007063)3.23712325
66regulation of chromosome segregation (GO:0051983)3.23041128
67DNA strand renaturation (GO:0000733)3.21814459
68sister chromatid segregation (GO:0000819)3.21109788
69DNA catabolic process, exonucleolytic (GO:0000738)3.17254122
70monoubiquitinated protein deubiquitination (GO:0035520)3.16999931
71response to X-ray (GO:0010165)3.14656209
72regulation of mitotic spindle organization (GO:0060236)3.11690376
73regulation of mitotic metaphase/anaphase transition (GO:0030071)3.11644733
74regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.10981292
75spindle checkpoint (GO:0031577)3.10831436
76chromosome segregation (GO:0007059)3.09667732
77telomere maintenance via telomere lengthening (GO:0010833)3.05450734
78DNA damage response, detection of DNA damage (GO:0042769)3.02780466
79synapsis (GO:0007129)3.02623397
80regulation of helicase activity (GO:0051095)3.02056149
81exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01184111
82recombinational repair (GO:0000725)3.00700332
83ribosomal small subunit assembly (GO:0000028)3.00532308
84nucleotide-excision repair, DNA gap filling (GO:0006297)2.99972049
85mitotic G2 DNA damage checkpoint (GO:0007095)2.99327984
86chromatin assembly or disassembly (GO:0006333)2.98967696
87centriole replication (GO:0007099)2.98853975
88sister chromatid cohesion (GO:0007062)2.98580811
89double-strand break repair via homologous recombination (GO:0000724)2.98173753
90regulation of centrosome cycle (GO:0046605)2.97191181
91regulation of double-strand break repair (GO:2000779)2.95953399
92negative regulation of mitotic sister chromatid separation (GO:2000816)2.95891191
93negative regulation of mitotic sister chromatid segregation (GO:0033048)2.95891191
94negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.95891191
95negative regulation of sister chromatid segregation (GO:0033046)2.95891191
96negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.95495960
97nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.95483181
98negative regulation of chromosome segregation (GO:0051985)2.95148305
99resolution of meiotic recombination intermediates (GO:0000712)2.94394340
100synaptonemal complex assembly (GO:0007130)2.93051687
101maturation of SSU-rRNA (GO:0030490)2.92988590
102meiotic nuclear division (GO:0007126)2.92366551
103regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92127748
104regulation of mitotic sister chromatid separation (GO:0010965)2.91502437
105regulation of mitotic sister chromatid segregation (GO:0033047)2.91502437
106regulation of sister chromatid segregation (GO:0033045)2.91502437
107anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90776339
108somatic diversification of immune receptors via somatic mutation (GO:0002566)2.89320509
109somatic hypermutation of immunoglobulin genes (GO:0016446)2.89320509
110negative regulation of histone methylation (GO:0031061)2.87725611
111maturation of 5.8S rRNA (GO:0000460)2.86057871
112ATP-dependent chromatin remodeling (GO:0043044)2.85426259
113spindle assembly checkpoint (GO:0071173)2.84329201
114pore complex assembly (GO:0046931)2.83887270
115mitotic spindle checkpoint (GO:0071174)2.83169454
116mitotic spindle assembly checkpoint (GO:0007094)2.79887292
117formation of translation preinitiation complex (GO:0001731)2.79766687
118ribosome biogenesis (GO:0042254)2.79501157
119regulation of centriole replication (GO:0046599)2.78789749
120telomere organization (GO:0032200)2.78566149
121telomere maintenance (GO:0000723)2.78432592
122translesion synthesis (GO:0019985)2.78413750
123chromosome condensation (GO:0030261)2.78288500
124mismatch repair (GO:0006298)2.76338812
125ribosome assembly (GO:0042255)2.75985590
126DNA duplex unwinding (GO:0032508)2.75383036
127postreplication repair (GO:0006301)2.74362801
128regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.74345501
129regulation of mitotic spindle checkpoint (GO:1903504)2.74345501
130binding of sperm to zona pellucida (GO:0007339)2.73815363
131DNA geometric change (GO:0032392)2.73742474

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.23954144
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.48767383
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.82493370
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.44266976
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.41019413
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.26887040
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79028318
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.75769698
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.67691399
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.51377336
11AR_21909140_ChIP-Seq_LNCAP_Human2.51145096
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.51034148
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31661073
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27041907
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.25847701
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24870219
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18098476
18EWS_26573619_Chip-Seq_HEK293_Human2.17320349
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.15997739
20* VDR_23849224_ChIP-Seq_CD4+_Human2.14661079
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.10587064
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09032071
23FUS_26573619_Chip-Seq_HEK293_Human2.06041224
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04294480
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00924162
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.97807801
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97741428
28* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97723860
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95370114
30VDR_22108803_ChIP-Seq_LS180_Human1.94490225
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93311499
32* XRN2_22483619_ChIP-Seq_HELA_Human1.90355658
33DCP1A_22483619_ChIP-Seq_HELA_Human1.89078697
34FOXP3_21729870_ChIP-Seq_TREG_Human1.86409211
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.84594223
36GABP_19822575_ChIP-Seq_HepG2_Human1.75628161
37* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72384548
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71132002
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70658258
40ZNF274_21170338_ChIP-Seq_K562_Hela1.70145346
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69700942
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.60855283
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60140050
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59200997
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58044170
46MYC_22102868_ChIP-Seq_BL_Human1.57449718
47KDM5A_27292631_Chip-Seq_BREAST_Human1.56667227
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56539212
49IGF1R_20145208_ChIP-Seq_DFB_Human1.55844648
50TTF2_22483619_ChIP-Seq_HELA_Human1.51503870
51* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51495945
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50731684
53IRF1_19129219_ChIP-ChIP_H3396_Human1.48474897
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45635905
55* ELK1_19687146_ChIP-ChIP_HELA_Human1.42698587
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41670758
57TAF15_26573619_Chip-Seq_HEK293_Human1.40129657
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40026314
59CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.38348955
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37353994
61* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37318139
62P300_19829295_ChIP-Seq_ESCs_Human1.37132806
63HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37062847
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.34956930
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.34680323
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32336507
67CIITA_25753668_ChIP-Seq_RAJI_Human1.30972872
68* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30194596
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28782338
70TFEB_21752829_ChIP-Seq_HELA_Human1.27725347
71HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26804892
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26401362
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.25483178
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.24944235
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.23230180
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20972689
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19934662
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18863485
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.16089076
80THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15708408
81SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15614722
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.14980174
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11827555
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11787434
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09659073
86* SPI1_23547873_ChIP-Seq_NB4_Human1.08501629
87* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07929090
88GBX2_23144817_ChIP-Seq_PC3_Human1.07034738
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05825208
90CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03232253
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02085325
92* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00893638
93ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00744017
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99672501
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98773847
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98160902
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97623614
98MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97591742
99PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96090253
100NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.93910715
101MYC_18940864_ChIP-ChIP_HL60_Human0.93265380
102PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92512377
103ER_23166858_ChIP-Seq_MCF-7_Human0.92178861
104IRF8_21731497_ChIP-ChIP_J774_Mouse0.92037711
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91574601
106* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90575696
107STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90209194
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89726407
109CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89464424
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88261660
111MYB_26560356_Chip-Seq_TH1_Human0.87926474
112KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86334871
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85360635
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85282500
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85141306
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84741599
117VDR_21846776_ChIP-Seq_THP-1_Human0.84621300
118TP63_19390658_ChIP-ChIP_HaCaT_Human0.84592516
119EZH2_27294783_Chip-Seq_NPCs_Mouse0.84539325
120YY1_21170310_ChIP-Seq_MESCs_Mouse0.84426224
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83888412
122MYB_26560356_Chip-Seq_TH2_Human0.83679631
123* NANOG_21062744_ChIP-ChIP_HESCs_Human0.83198948
124IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82568925
125CBP_20019798_ChIP-Seq_JUKART_Human0.82568925
126* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81237095
127KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.80588829
128KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.80588829
129KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.80588829
130CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80455935
131GATA2_22383799_ChIP-Seq_G1ME_Mouse0.78940570
132MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.78383269
133CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.76081955
134POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.73435164
135BRD4_27068464_Chip-Seq_AML-cells_Mouse0.71182197
136* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.70138268
137UTX_26944678_Chip-Seq_JUKART_Human0.68046122
138CHD1_26751641_Chip-Seq_LNCaP_Human0.66411775
139CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.66387136
140POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.66070517

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.91182249
2MP0010094_abnormal_chromosome_stability4.58662607
3MP0008057_abnormal_DNA_replication4.14405317
4MP0003111_abnormal_nucleus_morphology3.83390558
5MP0004957_abnormal_blastocyst_morpholog3.81275310
6MP0003077_abnormal_cell_cycle3.54007079
7MP0008058_abnormal_DNA_repair3.22741964
8MP0008877_abnormal_DNA_methylation3.06940430
9MP0006292_abnormal_olfactory_placode2.67382979
10MP0003123_paternal_imprinting2.48234022
11MP0008007_abnormal_cellular_replicative2.47044467
12MP0001188_hyperpigmentation2.43075365
13MP0000566_synostosis2.28454212
14MP0002396_abnormal_hematopoietic_system2.13587411
15MP0003718_maternal_effect2.10292542
16MP0001529_abnormal_vocalization2.09459355
17MP0008932_abnormal_embryonic_tissue2.08720158
18MP0001730_embryonic_growth_arrest2.03220108
19MP0008789_abnormal_olfactory_epithelium1.91169366
20MP0000350_abnormal_cell_proliferation1.90700977
21MP0001929_abnormal_gametogenesis1.88517561
22MP0002210_abnormal_sex_determination1.75063301
23MP0003941_abnormal_skin_development1.74489289
24MP0003880_abnormal_central_pattern1.72223196
25MP0010307_abnormal_tumor_latency1.67385832
26MP0003121_genomic_imprinting1.62562527
27MP0003806_abnormal_nucleotide_metabolis1.58886418
28MP0002938_white_spotting1.57000548
29MP0005499_abnormal_olfactory_system1.55294292
30MP0005394_taste/olfaction_phenotype1.55294292
31MP0000490_abnormal_crypts_of1.54037655
32MP0001697_abnormal_embryo_size1.53968707
33MP0005380_embryogenesis_phenotype1.53055797
34MP0001672_abnormal_embryogenesis/_devel1.53055797
35MP0006054_spinal_hemorrhage1.51552634
36MP0001145_abnormal_male_reproductive1.51276072
37MP0003122_maternal_imprinting1.49445507
38MP0000653_abnormal_sex_gland1.42770088
39MP0002233_abnormal_nose_morphology1.42484470
40MP0003136_yellow_coat_color1.42129965
41MP0002019_abnormal_tumor_incidence1.40698708
42MP0003984_embryonic_growth_retardation1.40384531
43MP0005410_abnormal_fertilization1.38856278
44MP0003119_abnormal_digestive_system1.38059901
45MP0008995_early_reproductive_senescence1.37502165
46MP0005397_hematopoietic_system_phenotyp1.36676982
47MP0001545_abnormal_hematopoietic_system1.36676982
48MP0002088_abnormal_embryonic_growth/wei1.36572211
49MP0002080_prenatal_lethality1.33200627
50MP0002398_abnormal_bone_marrow1.32424171
51MP0006072_abnormal_retinal_apoptosis1.31865849
52MP0010352_gastrointestinal_tract_polyps1.31415851
53MP0003763_abnormal_thymus_physiology1.30622656
54MP0000313_abnormal_cell_death1.30376708
55MP0004808_abnormal_hematopoietic_stem1.29240113
56MP0000689_abnormal_spleen_morphology1.26332045
57MP0001119_abnormal_female_reproductive1.23131630
58MP0003786_premature_aging1.22955095
59MP0002877_abnormal_melanocyte_morpholog1.20993021
60MP0002085_abnormal_embryonic_tissue1.20706732
61MP0000372_irregular_coat_pigmentation1.20211168
62MP0001286_abnormal_eye_development1.19745542
63MP0003656_abnormal_erythrocyte_physiolo1.18560527
64MP0002084_abnormal_developmental_patter1.18107301
65MP0002086_abnormal_extraembryonic_tissu1.17895783
66MP0003698_abnormal_male_reproductive1.16309662
67MP0002751_abnormal_autonomic_nervous1.15402274
68MP0000703_abnormal_thymus_morphology1.14460396
69MP0009379_abnormal_foot_pigmentation1.14150121
70MP0000858_altered_metastatic_potential1.13463693
71MP0005076_abnormal_cell_differentiation1.12736710
72MP0002722_abnormal_immune_system1.12654920
73MP0003186_abnormal_redox_activity1.11846622
74MP0006276_abnormal_autonomic_nervous1.11405336
75MP0001800_abnormal_humoral_immune1.09767844
76MP0002234_abnormal_pharynx_morphology1.09713512
77MP0000631_abnormal_neuroendocrine_gland1.07791223
78MP0000049_abnormal_middle_ear1.07290228
79MP0004197_abnormal_fetal_growth/weight/1.07260423
80MP0000647_abnormal_sebaceous_gland1.06514981
81MP0005253_abnormal_eye_physiology1.05278504
82MP0003755_abnormal_palate_morphology1.05110561
83MP0000465_gastrointestinal_hemorrhage1.00794082
84MP0009672_abnormal_birth_weight1.00400410
85MP0003567_abnormal_fetal_cardiomyocyte1.00374521
86MP0002429_abnormal_blood_cell0.99897034
87MP0002697_abnormal_eye_size0.99461730
88MP0001915_intracranial_hemorrhage0.98587849
89MP0000716_abnormal_immune_system0.96458728
90MP0005187_abnormal_penis_morphology0.95663205
91MP0005408_hypopigmentation0.95343843
92MP0003861_abnormal_nervous_system0.95295914
93MP0003699_abnormal_female_reproductive0.93496659
94MP0010030_abnormal_orbit_morphology0.93422846
95MP0002161_abnormal_fertility/fecundity0.92326572
96MP0002111_abnormal_tail_morphology0.90634083
97MP0002736_abnormal_nociception_after0.90551847
98MP0002138_abnormal_hepatobiliary_system0.90144390
99MP0002163_abnormal_gland_morphology0.90006278
100MP0002405_respiratory_system_inflammati0.89090378
101MP0005645_abnormal_hypothalamus_physiol0.88801988
102MP0002420_abnormal_adaptive_immunity0.87945330
103MP0001764_abnormal_homeostasis0.87578166
104MP0002452_abnormal_antigen_presenting0.86756955
105MP0009697_abnormal_copulation0.86701724
106MP0001819_abnormal_immune_cell0.86005325
107MP0001485_abnormal_pinna_reflex0.85834529
108MP0005671_abnormal_response_to0.85685435
109MP0001177_atelectasis0.85572659
110MP0003436_decreased_susceptibility_to0.84982348
111MP0002160_abnormal_reproductive_system0.84396432
112MP0003787_abnormal_imprinting0.83774416
113MP0005084_abnormal_gallbladder_morpholo0.83764145
114MP0002723_abnormal_immune_serum0.83248242
115MP0002009_preneoplasia0.83048357
116MP0000428_abnormal_craniofacial_morphol0.82985069
117MP0005384_cellular_phenotype0.81846150
118MP0000778_abnormal_nervous_system0.81687761
119MP0000358_abnormal_cell_content/0.81479355
120MP0000685_abnormal_immune_system0.81168286
121MP0005391_vision/eye_phenotype0.80777533
122MP0009333_abnormal_splenocyte_physiolog0.79857774
123MP0003315_abnormal_perineum_morphology0.79519580
124MP0006035_abnormal_mitochondrial_morpho0.78090865
125MP0005621_abnormal_cell_physiology0.78060360
126MP0004264_abnormal_extraembryonic_tissu0.77820856
127MP0002095_abnormal_skin_pigmentation0.77607154
128MP0005395_other_phenotype0.76912848
129MP0003890_abnormal_embryonic-extraembry0.76311713
130MP0004133_heterotaxia0.75421379
131MP0005000_abnormal_immune_tolerance0.75324446
132MP0002102_abnormal_ear_morphology0.74720291
133MP0002132_abnormal_respiratory_system0.74555173
134MP0003935_abnormal_craniofacial_develop0.73388527
135MP0006036_abnormal_mitochondrial_physio0.72426086
136MP0001835_abnormal_antigen_presentation0.71523085
137MP0001293_anophthalmia0.67312302
138MP0003221_abnormal_cardiomyocyte_apopto0.66178683
139MP0005174_abnormal_tail_pigmentation0.65497521
140MP0000427_abnormal_hair_cycle0.64740460
141MP0005451_abnormal_body_composition0.64492123
142MP0009053_abnormal_anal_canal0.64345579
143MP0000598_abnormal_liver_morphology0.63093874
144MP0005023_abnormal_wound_healing0.62185577
145MP0003937_abnormal_limbs/digits/tail_de0.61485234
146MP0005389_reproductive_system_phenotype0.61052811
147MP0002653_abnormal_ependyma_morphology0.60156003
148MP0005220_abnormal_exocrine_pancreas0.59289315
149MP0001790_abnormal_immune_system0.58890553
150MP0005387_immune_system_phenotype0.58890553
151MP0009703_decreased_birth_body0.58476736
152MP0009278_abnormal_bone_marrow0.57818082

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.11592233
2Chromsome breakage (HP:0040012)4.20103103
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.84284360
4Aplastic anemia (HP:0001915)3.75833284
5Abnormality of chromosome stability (HP:0003220)3.60133012
6Abnormal spermatogenesis (HP:0008669)3.46997236
7Abnormality of the anterior horn cell (HP:0006802)3.25853915
8Degeneration of anterior horn cells (HP:0002398)3.25853915
9Oral leukoplakia (HP:0002745)3.25190661
10Breast hypoplasia (HP:0003187)3.24693450
11Patellar aplasia (HP:0006443)3.09985636
12Reticulocytopenia (HP:0001896)3.07091213
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.99819695
14Supernumerary spleens (HP:0009799)2.96771200
15Methylmalonic acidemia (HP:0002912)2.94346201
16Tongue fasciculations (HP:0001308)2.93731918
17Hyperglycinemia (HP:0002154)2.93287173
18Carpal bone hypoplasia (HP:0001498)2.92444577
19Meckel diverticulum (HP:0002245)2.90909966
20Ectopic kidney (HP:0000086)2.90609499
21Aplasia/Hypoplasia of the patella (HP:0006498)2.86847206
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.84967819
23Azoospermia (HP:0000027)2.83188877
24Impulsivity (HP:0100710)2.81027308
25Methylmalonic aciduria (HP:0012120)2.80455778
26Abnormality of the preputium (HP:0100587)2.78153818
27Abnormality of the ileum (HP:0001549)2.76330248
28Myelodysplasia (HP:0002863)2.71679385
29Embryonal renal neoplasm (HP:0011794)2.70038281
30Agnosia (HP:0010524)2.67133538
31Facial hemangioma (HP:0000329)2.61546474
32Bone marrow hypocellularity (HP:0005528)2.59413055
33Duodenal stenosis (HP:0100867)2.51018584
34Small intestinal stenosis (HP:0012848)2.51018584
35Intestinal atresia (HP:0011100)2.50295917
36Absent thumb (HP:0009777)2.50052551
37Colon cancer (HP:0003003)2.49588077
38Medulloblastoma (HP:0002885)2.48621618
39Muscle fibrillation (HP:0010546)2.45958405
40Sloping forehead (HP:0000340)2.43558361
41Abnormality of cells of the erythroid lineage (HP:0012130)2.41976217
42Abnormal number of erythroid precursors (HP:0012131)2.40626062
43Abnormality of lateral ventricle (HP:0030047)2.37061998
44Secondary amenorrhea (HP:0000869)2.28951936
45Abnormality of the labia minora (HP:0012880)2.27695157
46Acute myeloid leukemia (HP:0004808)2.24442531
47Septo-optic dysplasia (HP:0100842)2.24432264
48Rough bone trabeculation (HP:0100670)2.24264615
49Selective tooth agenesis (HP:0001592)2.23618506
50Hypoplasia of the capital femoral epiphysis (HP:0003090)2.21354478
51Abnormality of the fingertips (HP:0001211)2.21171287
52Glioma (HP:0009733)2.20916300
53True hermaphroditism (HP:0010459)2.18314640
54Pancreatic islet-cell hyperplasia (HP:0004510)2.17155324
5511 pairs of ribs (HP:0000878)2.15852759
56Abnormality of pyrimidine metabolism (HP:0004353)2.15266997
57Biliary tract neoplasm (HP:0100574)2.14925104
58Abnormality of the metopic suture (HP:0005556)2.12582519
59Ependymoma (HP:0002888)2.11662074
60Neoplasm of the pancreas (HP:0002894)2.10996396
61Combined immunodeficiency (HP:0005387)2.10443051
62Male infertility (HP:0003251)2.10286962
63Volvulus (HP:0002580)2.08679233
64Increased nuchal translucency (HP:0010880)2.08015875
65Lymphoma (HP:0002665)2.07978827
66Cortical dysplasia (HP:0002539)2.07952103
67Nasal polyposis (HP:0100582)2.05936995
68Chronic bronchitis (HP:0004469)2.05602311
69High pitched voice (HP:0001620)2.03788539
70Abnormality of glycine metabolism (HP:0010895)2.03616281
71Abnormality of serine family amino acid metabolism (HP:0010894)2.03616281
72Gonadotropin excess (HP:0000837)2.03522356
73Pancreatic cysts (HP:0001737)2.02902947
74Absent radius (HP:0003974)2.02133317
75Prominent metopic ridge (HP:0005487)2.00385020
76Cafe-au-lait spot (HP:0000957)1.99647096
77Pancytopenia (HP:0001876)1.99589997
78Horseshoe kidney (HP:0000085)1.98668693
79Aplasia/Hypoplasia of the sternum (HP:0006714)1.96384295
80Premature ovarian failure (HP:0008209)1.96021605
81IgM deficiency (HP:0002850)1.95013783
82Abnormality of the duodenum (HP:0002246)1.94328225
83Bronchitis (HP:0012387)1.94223465
84Neoplasm of the adrenal cortex (HP:0100641)1.94159712
85Pulmonary fibrosis (HP:0002206)1.93486689
86Premature graying of hair (HP:0002216)1.92970042
87Abnormality of the phalanges of the hallux (HP:0010057)1.92061277
88T lymphocytopenia (HP:0005403)1.91891713
89Medial flaring of the eyebrow (HP:0010747)1.91054635
90Oligodactyly (hands) (HP:0001180)1.90073597
91Neoplasm of the adrenal gland (HP:0100631)1.87932800
92Astigmatism (HP:0000483)1.87806445
93Basal cell carcinoma (HP:0002671)1.87781594
94Rhabdomyosarcoma (HP:0002859)1.87590668
95Acute encephalopathy (HP:0006846)1.87553505
96Astrocytoma (HP:0009592)1.87438988
97Abnormality of the astrocytes (HP:0100707)1.87438988
98Cellular immunodeficiency (HP:0005374)1.87054685
99Recurrent bronchitis (HP:0002837)1.86637568
100Abnormality of DNA repair (HP:0003254)1.86349438
101Capillary hemangiomas (HP:0005306)1.86028018
102Abnormality of the pons (HP:0007361)1.85837072
103Megaloblastic anemia (HP:0001889)1.85177692
104Neoplasm of the colon (HP:0100273)1.83815528
105Absent septum pellucidum (HP:0001331)1.83654664
106Abnormality of the heme biosynthetic pathway (HP:0010472)1.82915922
107Hypoplasia of the pons (HP:0012110)1.82567489
108Abnormality of the vitamin B12 metabolism (HP:0004341)1.82547607
109Abnormality of serum amino acid levels (HP:0003112)1.82536314
110Postnatal microcephaly (HP:0005484)1.82441565
111Personality changes (HP:0000751)1.82335728
112Clubbing of toes (HP:0100760)1.82019881
113Abnormal lung lobation (HP:0002101)1.81950923
114Abnormal biliary tract morphology (HP:0012440)1.81923179
115Optic nerve hypoplasia (HP:0000609)1.81278735
116Increased hepatocellular lipid droplets (HP:0006565)1.80743047
117Neoplasm of the oral cavity (HP:0100649)1.80339728
118Embryonal neoplasm (HP:0002898)1.80098226
119Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79936351
120Flat capital femoral epiphysis (HP:0003370)1.79212278
121Acute necrotizing encephalopathy (HP:0006965)1.78490701
122Overlapping toe (HP:0001845)1.77540603
123Neoplasm of striated muscle (HP:0009728)1.76969815
124Tubulointerstitial nephritis (HP:0001970)1.76750099
125Pallor (HP:0000980)1.76582007
126Absent forearm bone (HP:0003953)1.75768301
127Aplasia involving forearm bones (HP:0009822)1.75768301
128Pancreatic fibrosis (HP:0100732)1.75496164
129Metaphyseal cupping (HP:0003021)1.75286460
130Hypoplastic pelvis (HP:0008839)1.74343832
131Abnormality of vitamin B metabolism (HP:0004340)1.74009662
132Clitoromegaly (HP:0000057)1.73762903
133Pendular nystagmus (HP:0012043)1.73628412
134Nephroblastoma (Wilms tumor) (HP:0002667)1.73130027
135Hypergonadotropic hypogonadism (HP:0000815)1.73028083
136Absent epiphyses (HP:0010577)1.72789166
137Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72789166
138Abnormality of T cell number (HP:0011839)1.72652687
139Ureteral duplication (HP:0000073)1.72278726
140Median cleft lip (HP:0000161)1.72137595
141Papillary thyroid carcinoma (HP:0002895)1.71831015
142Gastrointestinal atresia (HP:0002589)1.71452948
143Abnormality of the clitoris (HP:0000056)1.70618322
144Abnormality of the carotid arteries (HP:0005344)1.70498471
145Recurrent viral infections (HP:0004429)1.70370494
146Genital tract atresia (HP:0001827)1.70108389
147Triphalangeal thumb (HP:0001199)1.69772790
148Abnormality of methionine metabolism (HP:0010901)1.68973511
149Congenital primary aphakia (HP:0007707)1.68265100
150Bifid tongue (HP:0010297)1.67873382
151Nephrogenic diabetes insipidus (HP:0009806)1.67637064
152Preaxial hand polydactyly (HP:0001177)1.67224118
153Abnormality of the septum pellucidum (HP:0007375)1.67149335
154Oligodactyly (HP:0012165)1.67015072
155Vaginal atresia (HP:0000148)1.65560569
156Small hand (HP:0200055)1.65187483
157Lipid accumulation in hepatocytes (HP:0006561)1.64694337
158Stenosis of the external auditory canal (HP:0000402)1.64402979
159Aplasia/Hypoplasia of the tongue (HP:0010295)1.63978785
160Ovarian neoplasm (HP:0100615)1.63563596
161Ketoacidosis (HP:0001993)1.62473512
162Abnormality of midbrain morphology (HP:0002418)1.60969706
163Molar tooth sign on MRI (HP:0002419)1.60969706

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.60151011
2EIF2AK13.83603806
3WEE13.61088031
4NEK23.03913715
5BRSK22.77466763
6WNK32.73893873
7BUB12.71981369
8VRK22.53686662
9TTK2.48672188
10ACVR1B2.46084169
11PLK42.39072748
12TAF12.30206266
13SRPK12.25511729
14STK102.23351136
15TRIM282.15011385
16NUAK12.04776764
17PLK12.04744191
18MAP4K22.02785690
19STK38L1.85032663
20RPS6KA41.83297714
21PNCK1.77065907
22CHEK21.70057200
23SCYL21.66292983
24BCR1.61964301
25PDK41.61364468
26PDK31.61364468
27NEK11.61240064
28ATR1.60254382
29EIF2AK31.60199497
30MAP3K41.56873609
31CDK121.56257293
32DYRK31.55821633
33STK31.55706719
34VRK11.55022166
35TNIK1.45527979
36AURKB1.42521098
37PLK31.40814195
38MELK1.35301567
39CDK41.33541823
40BMPR1B1.33508857
41CASK1.27531830
42MAP4K11.23749313
43NEK91.23669129
44MAP3K81.22946385
45CDK71.22788267
46EEF2K1.19428372
47RPS6KB21.18811683
48CHEK11.18363736
49BRSK11.14828536
50ATM1.14018413
51PASK1.13563514
52NME21.11953162
53BRAF1.10233400
54ERBB31.10112231
55CDK81.08298101
56INSRR1.07565984
57CDK91.05759686
58CSNK1G31.01114308
59FRK1.01005599
60PLK21.00715979
61CSNK1G20.98865129
62STK240.98366574
63AURKA0.91843519
64TEC0.91449807
65PIM10.91157482
66CCNB10.91069580
67TLK10.90959272
68MKNK10.89932470
69CSNK1A1L0.89626337
70STK40.85538794
71CDK60.83773948
72NLK0.82383994
73TAOK30.81393416
74MAP2K70.80427183
75TGFBR10.76687002
76CDK20.75927155
77PDK20.75916018
78MAP3K100.74475530
79MARK30.73785138
80CDK190.68486049
81CDK30.64716413
82BRD40.64654901
83IRAK40.64598236
84TYK20.64597224
85MINK10.63718643
86GRK10.62927664
87LRRK20.62751562
88LATS10.62364215
89MAPK130.61828148
90PIK3CG0.61454967
91ITK0.60267015
92TESK20.59123736
93CDK10.57990395
94TSSK60.56953266
95CSNK2A10.54872349
96MKNK20.53772088
97PAK40.53469195
98BTK0.52145336
99CSNK2A20.51977812
100KIT0.50882813
101FGFR10.50442352
102MAP3K50.48894908
103ERBB40.48867125
104IRAK30.47972827
105ZAK0.46931176
106FLT30.46591071
107NME10.44724411
108EIF2AK20.43667391
109ALK0.42654026
110MAPK110.42383751
111STK390.42260791
112CSNK1E0.41351701
113CSK0.41263255
114FGFR20.40342366
115MAPKAPK30.40043560
116RPS6KB10.39617554
117JAK30.38541118
118CLK10.38517473
119MAP3K130.37990779
120DYRK20.37880237
121RAF10.36392657
122PRKCG0.36151674
123EPHA40.35817382
124PBK0.35795412
125MST40.35294620
126STK160.35133869
127OXSR10.34014102
128SIK30.32704203
129TRPM70.31989946
130CSF1R0.31054367
131YES10.30941381
132MAPKAPK50.30874872
133BCKDK0.30687620
134CDK180.30336947
135MAP3K110.30195459
136PRKDC0.29845804
137CDK140.29390029
138CSNK1D0.29106539
139LATS20.28997988
140SGK20.28548237
141MAP3K60.27414796
142ZAP700.25450344
143CSNK1G10.24597668

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.75958068
2Mismatch repair_Homo sapiens_hsa034303.84992364
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.34560905
4Cell cycle_Homo sapiens_hsa041103.30541576
5Homologous recombination_Homo sapiens_hsa034403.20427858
6Non-homologous end-joining_Homo sapiens_hsa034502.92536294
7RNA transport_Homo sapiens_hsa030132.90866189
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.89862338
9Base excision repair_Homo sapiens_hsa034102.81774443
10One carbon pool by folate_Homo sapiens_hsa006702.72934839
11Basal transcription factors_Homo sapiens_hsa030222.60951066
12Spliceosome_Homo sapiens_hsa030402.46671170
13Nucleotide excision repair_Homo sapiens_hsa034202.44853258
14* Fanconi anemia pathway_Homo sapiens_hsa034602.44227555
15RNA polymerase_Homo sapiens_hsa030202.40570733
16RNA degradation_Homo sapiens_hsa030182.21964290
17Ribosome_Homo sapiens_hsa030102.13117667
18Pyrimidine metabolism_Homo sapiens_hsa002402.10159458
19Proteasome_Homo sapiens_hsa030501.92346835
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.90181622
21p53 signaling pathway_Homo sapiens_hsa041151.72925265
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65977743
23mRNA surveillance pathway_Homo sapiens_hsa030151.62552774
24Folate biosynthesis_Homo sapiens_hsa007901.61051239
25Steroid biosynthesis_Homo sapiens_hsa001001.60524953
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39396523
27Protein export_Homo sapiens_hsa030601.32360524
28Vitamin B6 metabolism_Homo sapiens_hsa007501.30743601
29Oxidative phosphorylation_Homo sapiens_hsa001901.27435102
30Parkinsons disease_Homo sapiens_hsa050121.23345440
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20449285
32Selenocompound metabolism_Homo sapiens_hsa004501.19758076
33Antigen processing and presentation_Homo sapiens_hsa046121.19640157
34Epstein-Barr virus infection_Homo sapiens_hsa051691.19287181
35Pentose phosphate pathway_Homo sapiens_hsa000301.17867388
36Oocyte meiosis_Homo sapiens_hsa041141.16007831
37Purine metabolism_Homo sapiens_hsa002301.12966498
38Huntingtons disease_Homo sapiens_hsa050161.12639569
39Herpes simplex infection_Homo sapiens_hsa051681.11989142
40Butanoate metabolism_Homo sapiens_hsa006501.07200223
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01206402
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.95803833
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93058126
44Viral carcinogenesis_Homo sapiens_hsa052030.91751785
45Fatty acid elongation_Homo sapiens_hsa000620.90056885
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86396163
47Primary immunodeficiency_Homo sapiens_hsa053400.85839459
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85463065
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83804823
50Biosynthesis of amino acids_Homo sapiens_hsa012300.80709126
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75038061
52Phototransduction_Homo sapiens_hsa047440.73170334
53Thyroid cancer_Homo sapiens_hsa052160.73137945
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71203594
55Lysine degradation_Homo sapiens_hsa003100.69747847
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69408199
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66268007
58HTLV-I infection_Homo sapiens_hsa051660.64581292
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64410338
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64160655
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.64059810
62Basal cell carcinoma_Homo sapiens_hsa052170.63605586
63Alzheimers disease_Homo sapiens_hsa050100.62513086
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62308634
65Hedgehog signaling pathway_Homo sapiens_hsa043400.58863523
66Legionellosis_Homo sapiens_hsa051340.57786396
67MicroRNAs in cancer_Homo sapiens_hsa052060.57488299
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56592610
69B cell receptor signaling pathway_Homo sapiens_hsa046620.56442170
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.53679220
71Wnt signaling pathway_Homo sapiens_hsa043100.52634675
72Carbon metabolism_Homo sapiens_hsa012000.51512489
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51277245
74Fatty acid metabolism_Homo sapiens_hsa012120.51160855
75Pancreatic cancer_Homo sapiens_hsa052120.50464032
76Glutathione metabolism_Homo sapiens_hsa004800.49899319
77Hippo signaling pathway_Homo sapiens_hsa043900.49513992
78Systemic lupus erythematosus_Homo sapiens_hsa053220.48576695
79Measles_Homo sapiens_hsa051620.46824208
80Apoptosis_Homo sapiens_hsa042100.46623208
81Hepatitis B_Homo sapiens_hsa051610.45421073
82Small cell lung cancer_Homo sapiens_hsa052220.43278688
83Hematopoietic cell lineage_Homo sapiens_hsa046400.41676903
84Peroxisome_Homo sapiens_hsa041460.40630913
85Colorectal cancer_Homo sapiens_hsa052100.40263491
86Shigellosis_Homo sapiens_hsa051310.39753182
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.39526629
88Olfactory transduction_Homo sapiens_hsa047400.38785203
89Nicotine addiction_Homo sapiens_hsa050330.38666465
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37805465
91TGF-beta signaling pathway_Homo sapiens_hsa043500.37695180
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36471367
93Prostate cancer_Homo sapiens_hsa052150.36229241
94Regulation of autophagy_Homo sapiens_hsa041400.36184897
95Propanoate metabolism_Homo sapiens_hsa006400.36111797
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35834385
97Caffeine metabolism_Homo sapiens_hsa002320.35572885
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35529340
99Sulfur relay system_Homo sapiens_hsa041220.35489639
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.34224581
101Other glycan degradation_Homo sapiens_hsa005110.33761537
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32322926
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31926216
104Alcoholism_Homo sapiens_hsa050340.31177967
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30222460
106Influenza A_Homo sapiens_hsa051640.30178918
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30089761
108Staphylococcus aureus infection_Homo sapiens_hsa051500.28230681
109Ether lipid metabolism_Homo sapiens_hsa005650.26864446
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26815287
111N-Glycan biosynthesis_Homo sapiens_hsa005100.26451184
112Chronic myeloid leukemia_Homo sapiens_hsa052200.26323489
113Linoleic acid metabolism_Homo sapiens_hsa005910.25437680
114Pyruvate metabolism_Homo sapiens_hsa006200.24786657
115FoxO signaling pathway_Homo sapiens_hsa040680.24464102
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23730652
117T cell receptor signaling pathway_Homo sapiens_hsa046600.23721071
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23681361
119Acute myeloid leukemia_Homo sapiens_hsa052210.23648703
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.23485309
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22428616
122beta-Alanine metabolism_Homo sapiens_hsa004100.22186346
123Non-small cell lung cancer_Homo sapiens_hsa052230.21924145
124Vitamin digestion and absorption_Homo sapiens_hsa049770.21760750
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21511742
126Metabolic pathways_Homo sapiens_hsa011000.20488457
127Bladder cancer_Homo sapiens_hsa052190.18996668
128Tryptophan metabolism_Homo sapiens_hsa003800.17821510
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.16290240
130Leishmaniasis_Homo sapiens_hsa051400.15835943
131Renin-angiotensin system_Homo sapiens_hsa046140.15365677
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15277341
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15201544
134Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.14531990
135Fatty acid degradation_Homo sapiens_hsa000710.14011968
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.13659941
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13586663
138Dopaminergic synapse_Homo sapiens_hsa047280.13183378
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.13182211
140Cardiac muscle contraction_Homo sapiens_hsa042600.10899259
141Retinol metabolism_Homo sapiens_hsa008300.10551792
142Taste transduction_Homo sapiens_hsa047420.08736830
143Tight junction_Homo sapiens_hsa045300.08065150
144Adherens junction_Homo sapiens_hsa045200.07813564

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