RMI2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RMI2 is a component of the BLM (RECQL3; MIM 604610) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability (Xu et al., 2008 [PubMed 18923082]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)6.91100952
2negative regulation of mRNA splicing, via spliceosome (GO:0048025)5.71793936
3establishment of integrated proviral latency (GO:0075713)5.25901750
4negative regulation of mRNA processing (GO:0050686)5.08218057
5negative regulation of RNA splicing (GO:0033119)4.78262587
6folic acid-containing compound biosynthetic process (GO:0009396)4.70467022
7regulation of nuclear cell cycle DNA replication (GO:0033262)4.63036715
8heterochromatin organization (GO:0070828)4.60268870
9DNA deamination (GO:0045006)4.59844138
10negative regulation of mRNA metabolic process (GO:1903312)4.41733459
11translesion synthesis (GO:0019985)4.41347727
12mitotic chromosome condensation (GO:0007076)4.18789985
13establishment of viral latency (GO:0019043)4.13068320
14pyrimidine nucleoside triphosphate metabolic process (GO:0009147)4.07043615
15telomere maintenance via semi-conservative replication (GO:0032201)4.07029679
16base-excision repair (GO:0006284)4.06061297
17kinetochore assembly (GO:0051382)4.00412896
18nucleobase-containing small molecule interconversion (GO:0015949)3.88218395
19pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.85425794
20kinetochore organization (GO:0051383)3.73677426
21deoxyribose phosphate biosynthetic process (GO:0046385)3.73523462
222-deoxyribonucleotide biosynthetic process (GO:0009265)3.73523462
23telomere maintenance via recombination (GO:0000722)3.73293730
24ribosomal small subunit biogenesis (GO:0042274)3.70885810
25regulation of histone H3-K9 methylation (GO:0051570)3.70057521
26negative regulation of DNA-dependent DNA replication (GO:2000104)3.69316414
27pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.67436284
28somatic hypermutation of immunoglobulin genes (GO:0016446)3.66442895
29somatic diversification of immune receptors via somatic mutation (GO:0002566)3.66442895
30UTP biosynthetic process (GO:0006228)3.63072463
31rRNA modification (GO:0000154)3.58874320
32ribosomal large subunit biogenesis (GO:0042273)3.56561115
33mitotic sister chromatid segregation (GO:0000070)3.54611171
34purine nucleobase biosynthetic process (GO:0009113)3.51749384
35maturation of SSU-rRNA (GO:0030490)3.51171077
36CENP-A containing nucleosome assembly (GO:0034080)3.50765065
37termination of RNA polymerase III transcription (GO:0006386)3.50060291
38transcription elongation from RNA polymerase III promoter (GO:0006385)3.50060291
39telomere maintenance via telomere lengthening (GO:0010833)3.49972173
40termination of RNA polymerase II transcription (GO:0006369)3.47379525
41GTP biosynthetic process (GO:0006183)3.47350476
42postreplication repair (GO:0006301)3.46621344
43mitotic recombination (GO:0006312)3.44597703
44chromatin remodeling at centromere (GO:0031055)3.42646334
45protein localization to kinetochore (GO:0034501)3.41932112
46protein localization to chromosome, centromeric region (GO:0071459)3.41910937
47sister chromatid segregation (GO:0000819)3.41368985
48ribosomal small subunit assembly (GO:0000028)3.38698585
49DNA strand elongation involved in DNA replication (GO:0006271)3.36915982
50chromatin assembly or disassembly (GO:0006333)3.36910341
51DNA topological change (GO:0006265)3.35213661
52UTP metabolic process (GO:0046051)3.34792640
53L-serine metabolic process (GO:0006563)3.34133292
54DNA replication checkpoint (GO:0000076)3.33036422
55centrosome duplication (GO:0051298)3.32738403
56chromatin assembly (GO:0031497)3.32665832
57proteasome assembly (GO:0043248)3.31819856
58guanosine-containing compound biosynthetic process (GO:1901070)3.31229676
59negative regulation of telomerase activity (GO:0051974)3.31187060
60DNA synthesis involved in DNA repair (GO:0000731)3.30613399
61DNA replication-dependent nucleosome assembly (GO:0006335)3.30163099
62DNA replication-dependent nucleosome organization (GO:0034723)3.30163099
63DNA strand elongation (GO:0022616)3.30015467
64nucleobase biosynthetic process (GO:0046112)3.26646766
65folic acid metabolic process (GO:0046655)3.26340091
66termination of RNA polymerase I transcription (GO:0006363)3.26112237
67tetrahydrofolate metabolic process (GO:0046653)3.24642467
68IMP biosynthetic process (GO:0006188)3.24152614
69nuclear pore complex assembly (GO:0051292)3.23959661
70pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.23912157
71nucleotide-excision repair, DNA gap filling (GO:0006297)3.20170265
72DNA duplex unwinding (GO:0032508)3.19033028
73microtubule depolymerization (GO:0007019)3.18100888
74DNA replication initiation (GO:0006270)3.16792652
75transcription elongation from RNA polymerase I promoter (GO:0006362)3.16100389
76transcription-coupled nucleotide-excision repair (GO:0006283)3.15458618
77CTP metabolic process (GO:0046036)3.10510736
78CTP biosynthetic process (GO:0006241)3.10510736
79DNA damage response, detection of DNA damage (GO:0042769)3.10325822
80pteridine-containing compound biosynthetic process (GO:0042559)3.10231195
81double-strand break repair via nonhomologous end joining (GO:0006303)3.09818182
82non-recombinational repair (GO:0000726)3.09818182
83regulation of double-strand break repair via homologous recombination (GO:0010569)3.09546317
84deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.08437368
85DNA geometric change (GO:0032392)3.08172351
86protein K6-linked ubiquitination (GO:0085020)3.07871824
87rRNA methylation (GO:0031167)3.07652149
88preassembly of GPI anchor in ER membrane (GO:0016254)3.06770633
89superoxide anion generation (GO:0042554)3.06406626
907-methylguanosine mRNA capping (GO:0006370)3.05986495
91pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.05135461
92ribosome assembly (GO:0042255)3.03691323
93mitotic sister chromatid cohesion (GO:0007064)3.03270006
94pseudouridine synthesis (GO:0001522)3.02161537
95exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01925961
96RNA capping (GO:0036260)3.01836818
977-methylguanosine RNA capping (GO:0009452)3.01836818
98pyrimidine nucleotide biosynthetic process (GO:0006221)3.01365114
99transcription from RNA polymerase I promoter (GO:0006360)3.00632388
100centriole assembly (GO:0098534)2.99843548
101DNA-dependent DNA replication (GO:0006261)2.99268670
102pyrimidine nucleotide catabolic process (GO:0006244)2.98764095
103maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.97173536
104formation of translation preinitiation complex (GO:0001731)2.96892811
105nuclear pore organization (GO:0006999)2.96575769
106nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.96468006
107ribonucleoprotein complex biogenesis (GO:0022613)2.94909160
108viral mRNA export from host cell nucleus (GO:0046784)2.94706702
109viral transcription (GO:0019083)2.93579737
110DNA biosynthetic process (GO:0071897)2.93337273
111mitotic nuclear envelope disassembly (GO:0007077)2.92330884
112IMP metabolic process (GO:0046040)2.91686122
113regulation of translational fidelity (GO:0006450)2.90531050
114RNA-dependent DNA replication (GO:0006278)2.86162887
115meiotic chromosome segregation (GO:0045132)2.86102176
116DNA conformation change (GO:0071103)2.85886837
117tRNA methylation (GO:0030488)2.85848895
118telomere maintenance via telomerase (GO:0007004)2.85787979
119DNA ligation (GO:0006266)2.84950813
120spliceosomal snRNP assembly (GO:0000387)2.84502527
121translational termination (GO:0006415)2.84338457
122DNA catabolic process, exonucleolytic (GO:0000738)2.83157377
123spliceosomal complex assembly (GO:0000245)2.82978612
124rRNA processing (GO:0006364)2.81143297
125DNA replication-independent nucleosome assembly (GO:0006336)2.79873278
126DNA replication-independent nucleosome organization (GO:0034724)2.79873278
127deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.79686790
128deoxyribonucleotide biosynthetic process (GO:0009263)2.78313067
129rRNA metabolic process (GO:0016072)2.73651619
130regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.73331681
131DNA double-strand break processing (GO:0000729)2.71076661
132DNA integration (GO:0015074)2.70386635
133mitotic metaphase plate congression (GO:0007080)2.69098448
134positive regulation of DNA-dependent DNA replication (GO:2000105)2.67687222
135telomere maintenance (GO:0000723)2.67046858
136pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.66105432
137telomere organization (GO:0032200)2.64969713
138DNA-templated transcription, termination (GO:0006353)2.64483292
139maturation of 5.8S rRNA (GO:0000460)2.64411707
140transcription initiation from RNA polymerase I promoter (GO:0006361)2.64135820
141mismatch repair (GO:0006298)2.61946906
142intra-S DNA damage checkpoint (GO:0031573)2.59779430
143histone exchange (GO:0043486)2.59646528
144replication fork processing (GO:0031297)2.57459101
145DNA strand renaturation (GO:0000733)2.57128146
146GPI anchor biosynthetic process (GO:0006506)2.56917289
147centriole replication (GO:0007099)2.55999344
148nucleotide-excision repair (GO:0006289)2.55322017
149regulation of helicase activity (GO:0051095)2.54776801
150single strand break repair (GO:0000012)2.52129121
151regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.51711422
152RNA methylation (GO:0001510)2.50470853
153SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.49869631
154nucleoside diphosphate catabolic process (GO:0009134)2.49064107
155negative regulation of telomere maintenance (GO:0032205)2.48568967
156regulation of DNA-dependent DNA replication (GO:0090329)2.47947665
157histone mRNA metabolic process (GO:0008334)2.45644722
158ribosome biogenesis (GO:0042254)2.44254335
159regulation of mitochondrial translation (GO:0070129)2.44211956
160cotranslational protein targeting to membrane (GO:0006613)2.43573953
161tRNA modification (GO:0006400)2.42464707
162protein targeting to ER (GO:0045047)2.40305051
163* DNA replication (GO:0006260)2.40273385
164response to peptidoglycan (GO:0032494)2.40180145
165cellular component biogenesis (GO:0044085)2.39578874
166metaphase plate congression (GO:0051310)2.37616442

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.62719942
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.96288994
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.55241928
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.15748945
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.04036708
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.01198757
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.95594725
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.92385080
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.82249900
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.81205665
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.70452593
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.68322596
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.50697495
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.40605214
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.37837914
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.35879393
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.32701524
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.32394378
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17900167
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.16458570
21VDR_23849224_ChIP-Seq_CD4+_Human2.14704909
22AR_21909140_ChIP-Seq_LNCAP_Human2.13282234
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12539418
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11860464
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10748413
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.06485437
27MYC_22102868_ChIP-Seq_BL_Human2.06094524
28ELK1_19687146_ChIP-ChIP_HELA_Human2.03355426
29BP1_19119308_ChIP-ChIP_Hs578T_Human2.02899101
30FOXP3_21729870_ChIP-Seq_TREG_Human1.96528429
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95920707
32ZFX_18555785_ChIP-Seq_MESCs_Mouse1.95320724
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94211713
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93651807
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90221382
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.83655733
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.81746322
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77647981
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69626869
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.67734458
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.67127992
42CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.60196341
43TTF2_22483619_ChIP-Seq_HELA_Human1.57086489
44ZNF263_19887448_ChIP-Seq_K562_Human1.56712732
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.56345558
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56299394
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.54466097
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54300238
49IRF1_19129219_ChIP-ChIP_H3396_Human1.51836583
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50150763
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.49558264
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48525308
53VDR_21846776_ChIP-Seq_THP-1_Human1.46738284
54DCP1A_22483619_ChIP-Seq_HELA_Human1.45512488
55XRN2_22483619_ChIP-Seq_HELA_Human1.44703124
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44225584
57E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.43868566
58CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.43326041
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42151428
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41881665
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41273848
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39407274
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39208906
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36812057
65KDM5A_27292631_Chip-Seq_BREAST_Human1.36067170
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35942157
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34110462
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33665349
69MYC_18940864_ChIP-ChIP_HL60_Human1.31991402
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30184602
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28652705
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.25897264
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25318664
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24325674
75KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22750155
76KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22750155
77KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22750155
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20823755
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.12141207
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11979631
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11961766
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11390478
83CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11121704
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10735437
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10563389
86MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08596115
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.08014163
88NMYC_18555785_Chip-Seq_ESCs_Mouse1.07570406
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06498829
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04902005
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04206192
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03818431
93IGF1R_20145208_ChIP-Seq_DFB_Human1.03804091
94SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03693795
95BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02719004
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02709541
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02390385
98EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.02330619
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01017654
100ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00743824
101ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99747505
102KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99604683
103ZFX_18555785_Chip-Seq_ESCs_Mouse0.99452003
104NANOG_21062744_ChIP-ChIP_HESCs_Human0.98763919
105E2F1_18555785_Chip-Seq_ESCs_Mouse0.98261423
106RUNX1_27457419_Chip-Seq_LIVER_Mouse0.97345574
107SPI1_23547873_ChIP-Seq_NB4_Human0.97047082
108GABP_19822575_ChIP-Seq_HepG2_Human0.96859232
109ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95956607
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95361245
111SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95340687
112P300_18555785_Chip-Seq_ESCs_Mouse0.94802959
113POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94583797
114IRF8_22096565_ChIP-ChIP_GC-B_Human0.93964204
115OCT4_18555785_Chip-Seq_ESCs_Mouse0.93572505
116KLF4_18555785_Chip-Seq_ESCs_Mouse0.93176058
117P53_22387025_ChIP-Seq_ESCs_Mouse0.92490161
118CIITA_25753668_ChIP-Seq_RAJI_Human0.92269387
119KAP1_22055183_ChIP-Seq_ESCs_Mouse0.91900377
120TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91305237
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91273089
122RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90413803
123EWS_26573619_Chip-Seq_HEK293_Human0.89901938
124ELK1_22589737_ChIP-Seq_MCF10A_Human0.89566850
125SMAD1_18555785_Chip-Seq_ESCs_Mouse0.89170027
126FOXP1_21924763_ChIP-Seq_HESCs_Human0.88150296
127TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87284226
128EGR1_19374776_ChIP-ChIP_THP-1_Human0.86912028
129KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86851001
130TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85587962
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82503643
132CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82305397
133TBX5_21415370_ChIP-Seq_HL-1_Mouse0.81167102
134PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.80808426
135SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80492284
136TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.79012159
137SOX2_16153702_ChIP-ChIP_HESCs_Human0.78914577
138TCF3_18692474_ChIP-Seq_MEFs_Mouse0.78192349
139CTCF_18555785_ChIP-Seq_MESCs_Mouse0.77867290
140SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76045624
141SOX2_18555785_ChIP-Seq_MESCs_Mouse0.76012140

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.58719948
2MP0008057_abnormal_DNA_replication3.38221722
3MP0000566_synostosis3.34143884
4MP0003136_yellow_coat_color3.25920462
5MP0008058_abnormal_DNA_repair3.25108186
6MP0001986_abnormal_taste_sensitivity3.22997589
7MP0001188_hyperpigmentation3.17191453
8MP0010094_abnormal_chromosome_stability3.00843202
9MP0003111_abnormal_nucleus_morphology2.90731174
10MP0003693_abnormal_embryo_hatching2.90340152
11MP0009278_abnormal_bone_marrow2.81384462
12MP0003941_abnormal_skin_development2.42972887
13MP0002234_abnormal_pharynx_morphology2.36656998
14MP0005423_abnormal_somatic_nervous2.30504438
15MP0000350_abnormal_cell_proliferation2.28484513
16MP0003806_abnormal_nucleotide_metabolis2.27694365
17MP0004381_abnormal_hair_follicle2.27054572
18MP0005397_hematopoietic_system_phenotyp2.16405951
19MP0001545_abnormal_hematopoietic_system2.16405951
20MP0009379_abnormal_foot_pigmentation2.11698897
21MP0002102_abnormal_ear_morphology2.09892379
22MP0003077_abnormal_cell_cycle2.07061321
23MP0002277_abnormal_respiratory_mucosa2.06676105
24MP0002132_abnormal_respiratory_system2.00766609
25MP0005409_darkened_coat_color1.98701015
26MP0005076_abnormal_cell_differentiation1.95523566
27MP0001730_embryonic_growth_arrest1.93780153
28MP0000015_abnormal_ear_pigmentation1.93062414
29MP0003786_premature_aging1.90751250
30MP0005174_abnormal_tail_pigmentation1.86234072
31MP0008932_abnormal_embryonic_tissue1.78839851
32MP0004185_abnormal_adipocyte_glucose1.76465045
33MP0009672_abnormal_birth_weight1.72887361
34MP0004957_abnormal_blastocyst_morpholog1.62781912
35MP0001835_abnormal_antigen_presentation1.59651395
36MP0005380_embryogenesis_phenotype1.59311256
37MP0001672_abnormal_embryogenesis/_devel1.59311256
38MP0008007_abnormal_cellular_replicative1.58605178
39MP0008877_abnormal_DNA_methylation1.57396920
40MP0005075_abnormal_melanosome_morpholog1.55263535
41MP0001697_abnormal_embryo_size1.55094761
42MP0002396_abnormal_hematopoietic_system1.47692307
43MP0010307_abnormal_tumor_latency1.47566894
44MP0002080_prenatal_lethality1.47361430
45MP0003718_maternal_effect1.42044607
46MP0002085_abnormal_embryonic_tissue1.41699802
47MP0010352_gastrointestinal_tract_polyps1.41544250
48MP0003984_embryonic_growth_retardation1.41491887
49MP0005671_abnormal_response_to1.38446039
50MP0002095_abnormal_skin_pigmentation1.38428304
51MP0002163_abnormal_gland_morphology1.36630004
52MP0001881_abnormal_mammary_gland1.35162941
53MP0002148_abnormal_hypersensitivity_rea1.34396147
54MP0002088_abnormal_embryonic_growth/wei1.34196509
55MP0003763_abnormal_thymus_physiology1.31274495
56MP0005171_absent_coat_pigmentation1.29717877
57MP0002938_white_spotting1.24343414
58MP0003724_increased_susceptibility_to1.22665082
59MP0009785_altered_susceptibility_to1.21355494
60MP0008995_early_reproductive_senescence1.20982681
61MP0003119_abnormal_digestive_system1.19559500
62MP0000372_irregular_coat_pigmentation1.17358790
63MP0001346_abnormal_lacrimal_gland1.17300440
64MP0000490_abnormal_crypts_of1.13606541
65MP0005501_abnormal_skin_physiology1.12047631
66MP0001800_abnormal_humoral_immune1.10529258
67MP0010030_abnormal_orbit_morphology1.09829472
68MP0002638_abnormal_pupillary_reflex1.09236650
69MP0005000_abnormal_immune_tolerance1.09206211
70MP0005645_abnormal_hypothalamus_physiol1.08806967
71MP0002452_abnormal_antigen_presenting1.08417449
72MP0002084_abnormal_developmental_patter1.07402718
73MP0003123_paternal_imprinting1.06897515
74MP0002210_abnormal_sex_determination1.06815092
75MP0002723_abnormal_immune_serum1.04533477
76MP0008260_abnormal_autophagy1.04376464
77MP0000678_abnormal_parathyroid_gland1.03678457
78MP0000703_abnormal_thymus_morphology1.03511053
79MP0002420_abnormal_adaptive_immunity1.01963354
80MP0001819_abnormal_immune_cell1.01932368
81MP0003186_abnormal_redox_activity1.01829781
82MP0005387_immune_system_phenotype1.01706056
83MP0001790_abnormal_immune_system1.01706056
84MP0005379_endocrine/exocrine_gland_phen1.01210724
85MP0000049_abnormal_middle_ear0.99472343
86MP0002398_abnormal_bone_marrow0.99369114
87MP0001186_pigmentation_phenotype0.98829359
88MP0008789_abnormal_olfactory_epithelium0.98011188
89MP0002419_abnormal_innate_immunity0.96759151
90MP0003937_abnormal_limbs/digits/tail_de0.96488611
91MP0005025_abnormal_response_to0.95929630
92MP0002160_abnormal_reproductive_system0.95384506
93MP0004233_abnormal_muscle_weight0.94257105
94MP0002086_abnormal_extraembryonic_tissu0.94236137
95MP0004197_abnormal_fetal_growth/weight/0.94013644
96MP0009333_abnormal_splenocyte_physiolog0.93573569
97MP0001919_abnormal_reproductive_system0.90993631
98MP0000613_abnormal_salivary_gland0.90876955
99MP0003787_abnormal_imprinting0.90502117
100MP0003938_abnormal_ear_development0.89654732
101MP0005220_abnormal_exocrine_pancreas0.89613627
102MP0005389_reproductive_system_phenotype0.89442309
103MP0000627_abnormal_mammary_gland0.88498845
104MP0002751_abnormal_autonomic_nervous0.88159455
105MP0002111_abnormal_tail_morphology0.87865238
106MP0000716_abnormal_immune_system0.87806813
107MP0001853_heart_inflammation0.87114212
108MP0002722_abnormal_immune_system0.86490974
109MP0001119_abnormal_female_reproductive0.85735149
110MP0005384_cellular_phenotype0.85729800
111MP0003121_genomic_imprinting0.85281705
112MP0006036_abnormal_mitochondrial_physio0.85116573
113MP0005621_abnormal_cell_physiology0.84704602
114MP0000026_abnormal_inner_ear0.83427072
115MP0000313_abnormal_cell_death0.83051852
116MP0006035_abnormal_mitochondrial_morpho0.82472150
117MP0000689_abnormal_spleen_morphology0.81553610
118MP0002405_respiratory_system_inflammati0.79728019
119MP0002697_abnormal_eye_size0.78823198
120MP0000358_abnormal_cell_content/0.78162858
121MP0002796_impaired_skin_barrier0.77811405
122MP0003567_abnormal_fetal_cardiomyocyte0.77613978
123MP0003699_abnormal_female_reproductive0.77316154
124MP0004142_abnormal_muscle_tone0.76523062
125MP0001145_abnormal_male_reproductive0.76445514
126MP0001286_abnormal_eye_development0.75248620
127MP0001293_anophthalmia0.75080703
128MP0002075_abnormal_coat/hair_pigmentati0.74798211
129MP0002429_abnormal_blood_cell0.74537473
130MP0003890_abnormal_embryonic-extraembry0.74492473
131MP0001929_abnormal_gametogenesis0.72875267
132MP0004742_abnormal_vestibular_system0.72261850
133MP0003315_abnormal_perineum_morphology0.72104625
134MP0002249_abnormal_larynx_morphology0.71288519
135MP0005257_abnormal_intraocular_pressure0.70856644
136MP0004133_heterotaxia0.70636738
137MP0009697_abnormal_copulation0.70625886
138MP0005330_cardiomyopathy0.70380422
139MP0000653_abnormal_sex_gland0.70295054
140MP0002019_abnormal_tumor_incidence0.70275178
141MP0000470_abnormal_stomach_morphology0.68913297
142MP0000858_altered_metastatic_potential0.68012113
143MP0004808_abnormal_hematopoietic_stem0.67539015
144MP0003943_abnormal_hepatobiliary_system0.67225270
145MP0001661_extended_life_span0.66929222
146MP0005394_taste/olfaction_phenotype0.66199730
147MP0005499_abnormal_olfactory_system0.66199730
148MP0000537_abnormal_urethra_morphology0.64683289
149MP0009703_decreased_birth_body0.62548626
150MP0005666_abnormal_adipose_tissue0.62159656
151MP0002233_abnormal_nose_morphology0.60088345
152MP0003936_abnormal_reproductive_system0.59857623
153MP0003122_maternal_imprinting0.59676902
154MP0005451_abnormal_body_composition0.58754259
155MP0004510_myositis0.57639557
156MP0002092_abnormal_eye_morphology0.57296763

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.85429817
2Duplicated collecting system (HP:0000081)5.74201643
3Chromsome breakage (HP:0040012)5.46677865
4Abnormality of the renal collecting system (HP:0004742)5.27530642
5Colon cancer (HP:0003003)3.91311201
6Reticulocytopenia (HP:0001896)3.75699074
7Abnormality of the preputium (HP:0100587)3.40738196
8Clubbing of toes (HP:0100760)3.26086616
9Meckel diverticulum (HP:0002245)3.23550067
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.17355494
11Multiple enchondromatosis (HP:0005701)3.16986256
12Abnormality of the ileum (HP:0001549)3.12474680
13Progressive muscle weakness (HP:0003323)3.08358309
14Birth length less than 3rd percentile (HP:0003561)3.05771427
15Abnormality of chromosome stability (HP:0003220)3.05487334
16Abnormality of the labia minora (HP:0012880)3.05438616
17Abnormality of cochlea (HP:0000375)2.97041500
18Ragged-red muscle fibers (HP:0003200)2.93730794
19Acute lymphatic leukemia (HP:0006721)2.89021353
20Abnormality of DNA repair (HP:0003254)2.81429929
21Dysphonia (HP:0001618)2.78334047
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.70551291
23Increased nuchal translucency (HP:0010880)2.69219538
24Breast hypoplasia (HP:0003187)2.60971783
25Ectopic kidney (HP:0000086)2.54951505
26Embryonal renal neoplasm (HP:0011794)2.45286035
27Abnormal number of erythroid precursors (HP:0012131)2.40097757
28Bone marrow hypocellularity (HP:0005528)2.39734856
29Abnormality of cells of the erythroid lineage (HP:0012130)2.39314045
30Abnormality of the parathyroid morphology (HP:0011766)2.38636652
31Triphalangeal thumb (HP:0001199)2.37630425
32Selective tooth agenesis (HP:0001592)2.37479294
33Neoplasm of the adrenal cortex (HP:0100641)2.37115673
34Prostate neoplasm (HP:0100787)2.31886381
35Absent radius (HP:0003974)2.30978707
36Hepatocellular necrosis (HP:0001404)2.29921807
37Absent thumb (HP:0009777)2.29626532
38Duplication of thumb phalanx (HP:0009942)2.26451170
39Pallor (HP:0000980)2.25489542
40Congenital stationary night blindness (HP:0007642)2.24565905
41Abnormality of glycolysis (HP:0004366)2.18734871
42Granulocytopenia (HP:0001913)2.18463327
43Aplasia involving forearm bones (HP:0009822)2.18442047
44Absent forearm bone (HP:0003953)2.18442047
45Pulmonary artery stenosis (HP:0004415)2.18282382
46Neoplasm of the pancreas (HP:0002894)2.17498641
47Morphological abnormality of the inner ear (HP:0011390)2.14856962
48Lipid accumulation in hepatocytes (HP:0006561)2.14811129
49Long foot (HP:0001833)2.14270144
50High pitched voice (HP:0001620)2.13733970
51Microvesicular hepatic steatosis (HP:0001414)2.13554170
52Ureteral duplication (HP:0000073)2.12001993
53Conical tooth (HP:0000698)2.11957347
54Small intestinal stenosis (HP:0012848)2.11828199
55Duodenal stenosis (HP:0100867)2.11828199
56Increased serum pyruvate (HP:0003542)2.10997552
57Increased intramyocellular lipid droplets (HP:0012240)2.10914785
58Obstructive lung disease (HP:0006536)2.09652764
59Chronic obstructive pulmonary disease (HP:0006510)2.09652764
60Overriding aorta (HP:0002623)2.09609102
61Macrocytic anemia (HP:0001972)2.08810498
62Mitochondrial inheritance (HP:0001427)2.08307770
63Aplasia/Hypoplasia of the earlobes (HP:0009906)2.08096503
64Short thumb (HP:0009778)2.07031289
65Hyperglycinemia (HP:0002154)2.06815840
66Facial cleft (HP:0002006)2.06772163
673-Methylglutaconic aciduria (HP:0003535)2.06558349
68Abnormality of the carotid arteries (HP:0005344)2.06131766
69Septo-optic dysplasia (HP:0100842)2.06066059
70Broad distal phalanx of finger (HP:0009836)2.04831705
71Medulloblastoma (HP:0002885)2.00688131
72Type I transferrin isoform profile (HP:0003642)2.00400521
73Abnormality of incisor morphology (HP:0011063)1.99384124
74Overlapping toe (HP:0001845)1.99251608
75Abnormal mitochondria in muscle tissue (HP:0008316)1.99222301
76Aplasia/Hypoplasia of the sacrum (HP:0008517)1.98641473
77Progressive external ophthalmoplegia (HP:0000590)1.98423715
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97821808
79Stomach cancer (HP:0012126)1.96906520
80Hepatic necrosis (HP:0002605)1.96819185
81Myelodysplasia (HP:0002863)1.96776362
82Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96131459
83Patellar aplasia (HP:0006443)1.95707881
84Increased CSF lactate (HP:0002490)1.92898025
85Impulsivity (HP:0100710)1.92840731
86Premature graying of hair (HP:0002216)1.92197793
87Increased muscle lipid content (HP:0009058)1.91916216
88Upper limb muscle weakness (HP:0003484)1.90328598
89Achilles tendon contracture (HP:0001771)1.90199958
90Aplastic anemia (HP:0001915)1.89771548
91Cleft eyelid (HP:0000625)1.89765083
92Neoplasm of the adrenal gland (HP:0100631)1.89638432
93Partial duplication of thumb phalanx (HP:0009944)1.89196865
94Increased IgM level (HP:0003496)1.89152885
95Short middle phalanx of the 5th finger (HP:0004220)1.87897770
96Nasolacrimal duct obstruction (HP:0000579)1.87696456
97Recurrent abscess formation (HP:0002722)1.86182405
98Horseshoe kidney (HP:0000085)1.85356906
99Abnormality of the incisor (HP:0000676)1.85106339
100Embryonal neoplasm (HP:0002898)1.84810099
101Retrobulbar optic neuritis (HP:0100654)1.83492660
102Optic neuritis (HP:0100653)1.83492660
103Rough bone trabeculation (HP:0100670)1.83026818
104Hyperacusis (HP:0010780)1.82115349
105Abnormality of reticulocytes (HP:0004312)1.82103543
106Eosinophilia (HP:0001880)1.81538327
107Aplasia/Hypoplasia of the patella (HP:0006498)1.81508710
108Tracheoesophageal fistula (HP:0002575)1.81458187
109Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81234644
110Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81234644
111Abnormal lung lobation (HP:0002101)1.79441512
112IgG deficiency (HP:0004315)1.79034140
113Patent foramen ovale (HP:0001655)1.79008173
114Rectal prolapse (HP:0002035)1.78974247
115Recurrent pneumonia (HP:0006532)1.78558855
116Increased serum lactate (HP:0002151)1.78218959
117Pancytopenia (HP:0001876)1.77920217
118Cheilitis (HP:0100825)1.77901880
119Acute encephalopathy (HP:0006846)1.77842778
120Premature ovarian failure (HP:0008209)1.77775508
121True hermaphroditism (HP:0010459)1.77131198
122Abnormal number of incisors (HP:0011064)1.76449598
123Microretrognathia (HP:0000308)1.75998609
124Pancreatic cysts (HP:0001737)1.75917179
125Exertional dyspnea (HP:0002875)1.75120282
126Nephroblastoma (Wilms tumor) (HP:0002667)1.74413978
127Hyperglycinuria (HP:0003108)1.74348361
128Acute necrotizing encephalopathy (HP:0006965)1.74275267
129Neoplasm of the colon (HP:0100273)1.73701197
130Vaginal fistula (HP:0004320)1.73445476
131Spastic diplegia (HP:0001264)1.73322047
132Respiratory difficulties (HP:0002880)1.73032737
133Irregular epiphyses (HP:0010582)1.72803342
134Supernumerary spleens (HP:0009799)1.71942534
135Pseudobulbar signs (HP:0002200)1.71731565
136Rectovaginal fistula (HP:0000143)1.71619795
137Rectal fistula (HP:0100590)1.71619795
138Adactyly (HP:0009776)1.71608039
139Abnormal ciliary motility (HP:0012262)1.71423324
140Insomnia (HP:0100785)1.70956665
141IgM deficiency (HP:0002850)1.70659187
142Oral leukoplakia (HP:0002745)1.69221007
143Tubulointerstitial nephritis (HP:0001970)1.68531820
144Overfolded helix (HP:0000396)1.68463677
145Recurrent cutaneous fungal infections (HP:0011370)1.68339011
146Chronic mucocutaneous candidiasis (HP:0002728)1.68339011
147Parakeratosis (HP:0001036)1.67028935
148Renal Fanconi syndrome (HP:0001994)1.66786509
149Increased hepatocellular lipid droplets (HP:0006565)1.66397130
150Sloping forehead (HP:0000340)1.65491135
151Abnormality of the duodenum (HP:0002246)1.65354714
152Preaxial hand polydactyly (HP:0001177)1.63893591
153Abnormality of the columella (HP:0009929)1.63530488
154Type 2 muscle fiber atrophy (HP:0003554)1.63456691
155Hypergonadotropic hypogonadism (HP:0000815)1.63423721
156Abnormal respiratory motile cilium morphology (HP:0005938)1.62960814
157Abnormal respiratory epithelium morphology (HP:0012253)1.62960814
158Pancreatic fibrosis (HP:0100732)1.62937455
159Lymphoma (HP:0002665)1.60615897
160Aplasia cutis congenita (HP:0001057)1.60593004

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL25.11831684
2IRAK34.32696602
3STK163.73378501
4VRK23.65020019
5ZAK3.57959685
6IRAK43.25312155
7PLK42.90803387
8TLK12.59860205
9KDR2.57979736
10BUB12.56950494
11SRPK12.50858288
12MKNK22.43041253
13TXK2.14958140
14BCKDK2.12298225
15VRK12.03738391
16TAF11.96846657
17IRAK21.96196476
18SMG11.95576972
19IRAK11.95358704
20EIF2AK21.82739838
21EIF2AK11.78893674
22CASK1.76585216
23EEF2K1.75430359
24NEK11.71091464
25EIF2AK31.68559102
26BLK1.67616104
27TTK1.66723270
28MKNK11.66357852
29PBK1.59982530
30NME21.55840599
31YES11.55835123
32WEE11.51707816
33ATR1.41399971
34CDC71.35948766
35BRD41.29071841
36PIM21.28911423
37CLK11.25319150
38MAP3K101.25281992
39MAP3K141.24913351
40MAP3K111.16595060
41PLK11.16527021
42TNIK1.14916496
43CDK121.12748931
44AKT31.11957795
45CDK71.10707164
46TEC1.09900257
47ADRBK21.05078866
48DYRK31.04727665
49CHEK21.02753106
50STK41.02044536
51IKBKB1.00131144
52DMPK0.99165384
53MAP3K80.98698745
54BMPR1B0.95255668
55PASK0.94535760
56EPHA20.94349187
57NUAK10.93777818
58NEK60.93644830
59BMPR20.91753322
60CDC42BPA0.91251078
61NLK0.88484832
62MST40.87141861
63AURKB0.86012804
64STK38L0.81750480
65RPS6KA40.81547266
66ACVR1B0.80510857
67CDK80.79255729
68NME10.78916291
69GRK10.78577386
70PLK30.77918982
71NEK20.75691904
72LATS10.75411013
73GRK70.75183405
74RPS6KA50.74644859
75TNK20.73696193
76BRAF0.72898608
77ARAF0.71206722
78PIM10.71009343
79CDK30.70233937
80PRPF4B0.68086930
81DYRK20.66825962
82MAP4K10.65439254
83ATM0.65297522
84LYN0.64800463
85BRSK10.64524490
86IKBKE0.64128389
87CHEK10.62841168
88RIPK40.62724003
89AURKA0.59583221
90JAK30.57989097
91SIK30.57740212
92BTK0.57701951
93ALK0.55890929
94PINK10.54187656
95TAOK20.52928673
96PRKCI0.52852218
97CSNK2A10.50507160
98MAPKAPK50.48629053
99MAP3K130.47613878
100CDK90.45864846
101CDK190.44016880
102RPS6KB20.43838445
103BRSK20.43425734
104MAP2K20.41582093
105CCNB10.40204634
106LCK0.39566160
107MAPK130.38629988
108MELK0.38152361
109CHUK0.37012747
110CSNK2A20.36324235
111CDK40.35162073
112TESK20.35141098
113MAP2K70.35014257
114PRKDC0.34322477
115CDK20.34004836
116RPS6KC10.33520069
117RPS6KL10.33520069
118AKT10.33323592
119STK30.32997586
120CDK10.32948109
121CSNK1G30.32395056
122SYK0.32301639
123TYK20.31107518
124MAP2K60.30463386
125KIT0.30098395
126MARK10.30065172
127CSNK1E0.28989935
128TSSK60.28736373
129PRKCD0.28286713
130RPS6KA10.28227163
131PKN10.28207728
132CDK11A0.28094408
133CDK60.27963172
134CSNK1G10.27216613
135INSRR0.26836112
136MAP3K50.26402780
137MTOR0.26228342
138CDK150.25477167
139MAPK110.25313387
140MAPK140.24850908
141ABL20.24455833
142BMX0.23602986
143RPS6KA60.23330542
144EPHA30.23310128
145GSK3B0.23190166
146AKT20.23171218

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.69050039
2Ribosome_Homo sapiens_hsa030103.53512420
3Homologous recombination_Homo sapiens_hsa034403.36861363
4RNA polymerase_Homo sapiens_hsa030203.30769666
5Mismatch repair_Homo sapiens_hsa034303.21675109
6* Fanconi anemia pathway_Homo sapiens_hsa034603.10244614
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.62150911
8Nucleotide excision repair_Homo sapiens_hsa034202.46231065
9Spliceosome_Homo sapiens_hsa030402.46012746
10Base excision repair_Homo sapiens_hsa034102.42214267
11Pyrimidine metabolism_Homo sapiens_hsa002402.40137480
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.39475570
13Proteasome_Homo sapiens_hsa030502.20720599
14Basal transcription factors_Homo sapiens_hsa030222.09420432
15Non-homologous end-joining_Homo sapiens_hsa034502.04677168
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00053662
17Biosynthesis of amino acids_Homo sapiens_hsa012301.71418110
18RNA degradation_Homo sapiens_hsa030181.64016831
19One carbon pool by folate_Homo sapiens_hsa006701.63497946
20Cell cycle_Homo sapiens_hsa041101.62192097
21Primary immunodeficiency_Homo sapiens_hsa053401.59530676
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59057466
23RNA transport_Homo sapiens_hsa030131.57394949
24Purine metabolism_Homo sapiens_hsa002301.46024780
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.39327756
26Graft-versus-host disease_Homo sapiens_hsa053321.38522754
27Folate biosynthesis_Homo sapiens_hsa007901.34672359
28Pentose phosphate pathway_Homo sapiens_hsa000301.31173380
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27483239
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25764061
31p53 signaling pathway_Homo sapiens_hsa041151.23188723
32Oxidative phosphorylation_Homo sapiens_hsa001901.22327411
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.19102037
34Allograft rejection_Homo sapiens_hsa053301.18521118
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.17058649
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.16782752
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15946526
38Herpes simplex infection_Homo sapiens_hsa051681.13469050
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12406763
40Carbon metabolism_Homo sapiens_hsa012001.11128185
41Phototransduction_Homo sapiens_hsa047441.09691417
42mRNA surveillance pathway_Homo sapiens_hsa030151.07667204
43Protein export_Homo sapiens_hsa030601.07455833
44Autoimmune thyroid disease_Homo sapiens_hsa053201.07352611
45Huntingtons disease_Homo sapiens_hsa050161.05448140
46Measles_Homo sapiens_hsa051621.04358734
47Pyruvate metabolism_Homo sapiens_hsa006201.03357106
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01844465
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01463238
50Epstein-Barr virus infection_Homo sapiens_hsa051690.99918445
51Hematopoietic cell lineage_Homo sapiens_hsa046400.99867412
52Fatty acid elongation_Homo sapiens_hsa000620.98175132
53Asthma_Homo sapiens_hsa053100.95035731
54Systemic lupus erythematosus_Homo sapiens_hsa053220.92715418
55Sulfur relay system_Homo sapiens_hsa041220.92347606
56Parkinsons disease_Homo sapiens_hsa050120.91018886
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87340549
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86633818
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83136861
60Arachidonic acid metabolism_Homo sapiens_hsa005900.81103000
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80635329
62Oocyte meiosis_Homo sapiens_hsa041140.75547029
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74726661
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72151961
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69094040
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.68902035
67Sphingolipid metabolism_Homo sapiens_hsa006000.68562630
68Fructose and mannose metabolism_Homo sapiens_hsa000510.67528715
69Selenocompound metabolism_Homo sapiens_hsa004500.67036015
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66427700
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65306297
72Galactose metabolism_Homo sapiens_hsa000520.64429641
73Leishmaniasis_Homo sapiens_hsa051400.62998397
74Alzheimers disease_Homo sapiens_hsa050100.62273732
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62137036
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59683271
77Rheumatoid arthritis_Homo sapiens_hsa053230.58641732
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58413433
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57445072
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57370733
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56548670
82Other glycan degradation_Homo sapiens_hsa005110.56045553
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53212581
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52059331
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50292501
86Influenza A_Homo sapiens_hsa051640.49557182
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48787025
88Lysine degradation_Homo sapiens_hsa003100.48517158
89Vitamin B6 metabolism_Homo sapiens_hsa007500.48221066
90N-Glycan biosynthesis_Homo sapiens_hsa005100.47241520
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.46421878
92HTLV-I infection_Homo sapiens_hsa051660.46418141
93Type I diabetes mellitus_Homo sapiens_hsa049400.45946724
94Fatty acid metabolism_Homo sapiens_hsa012120.45411417
95Thyroid cancer_Homo sapiens_hsa052160.45305981
96Phenylalanine metabolism_Homo sapiens_hsa003600.44971923
97Apoptosis_Homo sapiens_hsa042100.44171477
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.42655300
99Ether lipid metabolism_Homo sapiens_hsa005650.40984379
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39635320
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39635143
102Viral carcinogenesis_Homo sapiens_hsa052030.39455919
103Malaria_Homo sapiens_hsa051440.39124207
104Legionellosis_Homo sapiens_hsa051340.35944449
105Notch signaling pathway_Homo sapiens_hsa043300.35274229
106Hepatitis B_Homo sapiens_hsa051610.34096709
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33959721
108Nicotine addiction_Homo sapiens_hsa050330.33947083
109Pertussis_Homo sapiens_hsa051330.32791245
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30831429
111Pancreatic cancer_Homo sapiens_hsa052120.30623203
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30446019
113TNF signaling pathway_Homo sapiens_hsa046680.30318429
114T cell receptor signaling pathway_Homo sapiens_hsa046600.29918122
115Basal cell carcinoma_Homo sapiens_hsa052170.29812850
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.28989755
117Arginine and proline metabolism_Homo sapiens_hsa003300.28678368
118Alcoholism_Homo sapiens_hsa050340.28480151
119African trypanosomiasis_Homo sapiens_hsa051430.27299376
120Linoleic acid metabolism_Homo sapiens_hsa005910.27200104
121Colorectal cancer_Homo sapiens_hsa052100.26245211
122Shigellosis_Homo sapiens_hsa051310.26175744
123Bladder cancer_Homo sapiens_hsa052190.26137837
124Tuberculosis_Homo sapiens_hsa051520.25601171
125Metabolic pathways_Homo sapiens_hsa011000.25399030
126Antigen processing and presentation_Homo sapiens_hsa046120.25204484
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24393087
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24382329
129Propanoate metabolism_Homo sapiens_hsa006400.24351528
130Vitamin digestion and absorption_Homo sapiens_hsa049770.23797219
131Osteoclast differentiation_Homo sapiens_hsa043800.23571084
132Glutathione metabolism_Homo sapiens_hsa004800.23012357
133Steroid biosynthesis_Homo sapiens_hsa001000.21995380
134Chemokine signaling pathway_Homo sapiens_hsa040620.21949755
135Peroxisome_Homo sapiens_hsa041460.20760797
136MicroRNAs in cancer_Homo sapiens_hsa052060.20425606
137Wnt signaling pathway_Homo sapiens_hsa043100.19320418
138Regulation of autophagy_Homo sapiens_hsa041400.19054917
139Small cell lung cancer_Homo sapiens_hsa052220.18956184
140Tyrosine metabolism_Homo sapiens_hsa003500.18885450
141Chronic myeloid leukemia_Homo sapiens_hsa052200.18750083
142Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18539979
143Hepatitis C_Homo sapiens_hsa051600.17974812
144Pathways in cancer_Homo sapiens_hsa052000.17161442
145Fatty acid degradation_Homo sapiens_hsa000710.17074793
146Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15241559
147Non-small cell lung cancer_Homo sapiens_hsa052230.09944903
148Prostate cancer_Homo sapiens_hsa052150.09464387
149Acute myeloid leukemia_Homo sapiens_hsa052210.09257926

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