RMND1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the evolutionary conserved sif2 family of proteins that share the DUF155 domain in common. This protein is thought to be localized in the mitochondria and involved in mitochondrial translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-11. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.90642980
2proteasome assembly (GO:0043248)4.43501377
3ATP synthesis coupled proton transport (GO:0015986)4.36384683
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.36384683
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.27268592
6chaperone-mediated protein transport (GO:0072321)4.16932893
7respiratory chain complex IV assembly (GO:0008535)4.07125290
8indole-containing compound catabolic process (GO:0042436)4.03534773
9indolalkylamine catabolic process (GO:0046218)4.03534773
10tryptophan catabolic process (GO:0006569)4.03534773
11mitochondrial respiratory chain complex I assembly (GO:0032981)3.95093356
12NADH dehydrogenase complex assembly (GO:0010257)3.95093356
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.95093356
14low-density lipoprotein particle remodeling (GO:0034374)3.89451496
15tryptophan metabolic process (GO:0006568)3.81100986
16aromatic amino acid family catabolic process (GO:0009074)3.77962616
17ribosomal small subunit assembly (GO:0000028)3.72646402
18protein complex biogenesis (GO:0070271)3.61558040
19L-phenylalanine catabolic process (GO:0006559)3.61079178
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.61079178
21cytochrome complex assembly (GO:0017004)3.52477384
22maturation of SSU-rRNA (GO:0030490)3.43640553
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.43553831
24NAD biosynthetic process (GO:0009435)3.41429882
25rRNA modification (GO:0000154)3.40741284
26quinone biosynthetic process (GO:1901663)3.31771080
27ubiquinone biosynthetic process (GO:0006744)3.31771080
28mitochondrial respiratory chain complex assembly (GO:0033108)3.30751216
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.28240344
30L-phenylalanine metabolic process (GO:0006558)3.28240344
31nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.27377458
32exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.26430414
33carnitine metabolic process (GO:0009437)3.23281895
34DNA ligation (GO:0006266)3.20067617
35chromatin remodeling at centromere (GO:0031055)3.19620890
36regulation of cholesterol esterification (GO:0010872)3.15663364
37translational termination (GO:0006415)3.14125749
38peptidyl-histidine modification (GO:0018202)3.14088880
39CENP-A containing nucleosome assembly (GO:0034080)3.11978908
40cotranslational protein targeting to membrane (GO:0006613)3.11909602
41cellular biogenic amine catabolic process (GO:0042402)3.11212805
42amine catabolic process (GO:0009310)3.11212805
43ribosomal large subunit biogenesis (GO:0042273)3.11070922
44pseudouridine synthesis (GO:0001522)3.10939441
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.10797914
46branched-chain amino acid catabolic process (GO:0009083)3.10051427
47viral transcription (GO:0019083)3.09525455
48aerobic respiration (GO:0009060)3.09296798
49amino-acid betaine metabolic process (GO:0006577)3.09241365
50DNA double-strand break processing (GO:0000729)3.08730909
51kynurenine metabolic process (GO:0070189)3.04378275
52protein targeting to ER (GO:0045047)3.03822666
53ribosomal small subunit biogenesis (GO:0042274)3.03482812
54water-soluble vitamin biosynthetic process (GO:0042364)3.03240285
55organic cation transport (GO:0015695)3.01648938
56rRNA methylation (GO:0031167)3.01055970
57indolalkylamine metabolic process (GO:0006586)3.00948975
58tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.00531015
59RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.00531015
60DNA replication checkpoint (GO:0000076)2.99192751
61* translation (GO:0006412)2.98596950
62fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.97323326
63transcription elongation from RNA polymerase III promoter (GO:0006385)2.96906520
64termination of RNA polymerase III transcription (GO:0006386)2.96906520
65ether lipid metabolic process (GO:0046485)2.96842728
66positive regulation of cellular amine metabolic process (GO:0033240)2.95628011
67establishment of protein localization to endoplasmic reticulum (GO:0072599)2.94984446
68regulation of mitochondrial translation (GO:0070129)2.93712995
69bile acid biosynthetic process (GO:0006699)2.92531531
70mannosylation (GO:0097502)2.92140018
71ubiquinone metabolic process (GO:0006743)2.90426671
72cellular component biogenesis (GO:0044085)2.89682051
73fatty acid beta-oxidation (GO:0006635)2.88911459
74protein-cofactor linkage (GO:0018065)2.87317298
75NAD metabolic process (GO:0019674)2.87249375
76protein localization to endoplasmic reticulum (GO:0070972)2.87015431
77translational initiation (GO:0006413)2.86605062
78mitochondrial RNA metabolic process (GO:0000959)2.86520403
79glyoxylate metabolic process (GO:0046487)2.86279283
80daunorubicin metabolic process (GO:0044597)2.85803905
81polyketide metabolic process (GO:0030638)2.85803905
82doxorubicin metabolic process (GO:0044598)2.85803905
83regulation of meiosis I (GO:0060631)2.85104806
84glucose 6-phosphate metabolic process (GO:0051156)2.85069407
85inner mitochondrial membrane organization (GO:0007007)2.84999643
86cullin deneddylation (GO:0010388)2.84335723
87cellular respiration (GO:0045333)2.84265408
88triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.82878001
89protein neddylation (GO:0045116)2.82520112
90ribonucleoprotein complex disassembly (GO:0032988)2.82186984
91tricarboxylic acid cycle (GO:0006099)2.78487235
92presynaptic membrane assembly (GO:0097105)2.78364922
93translational elongation (GO:0006414)2.77244248
94response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.76850079
95DNA damage response, detection of DNA damage (GO:0042769)2.76412099
96organelle disassembly (GO:1903008)2.74751159
97respiratory electron transport chain (GO:0022904)2.73618301
98negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.73064520
99negative regulation of DNA-dependent DNA replication (GO:2000104)2.72233391
100aminoglycoside antibiotic metabolic process (GO:0030647)2.71189706
101adenosine metabolic process (GO:0046085)2.70143194
102lysine catabolic process (GO:0006554)2.68757799
103lysine metabolic process (GO:0006553)2.68757799
104electron transport chain (GO:0022900)2.68203721
105superoxide anion generation (GO:0042554)2.68025155
106aromatic amino acid family metabolic process (GO:0009072)2.67381447
107histone exchange (GO:0043486)2.66957033
108motile cilium assembly (GO:0044458)2.66729301
109rRNA processing (GO:0006364)2.66671819
110branched-chain amino acid metabolic process (GO:0009081)2.66559129
111cellular ketone body metabolic process (GO:0046950)2.65720800
112positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.65708627
113formation of translation preinitiation complex (GO:0001731)2.65083939
114protein deneddylation (GO:0000338)2.64047596
115lipid oxidation (GO:0034440)2.63509359
116protein targeting to mitochondrion (GO:0006626)2.63425237
117intracellular protein transmembrane import (GO:0044743)2.63063239
118fatty acid catabolic process (GO:0009062)2.62963689
119prenylation (GO:0097354)2.62762536
120protein prenylation (GO:0018342)2.62762536
121protein-lipid complex remodeling (GO:0034368)2.62691374
122macromolecular complex remodeling (GO:0034367)2.62691374
123plasma lipoprotein particle remodeling (GO:0034369)2.62691374
124pyridine nucleotide biosynthetic process (GO:0019363)2.62240914
125nicotinamide nucleotide biosynthetic process (GO:0019359)2.62240914
126ribonucleoprotein complex biogenesis (GO:0022613)2.61392097
127positive regulation of protein homodimerization activity (GO:0090073)2.60950163
128platelet dense granule organization (GO:0060155)2.60789360
129regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.60537770
130high-density lipoprotein particle remodeling (GO:0034375)2.60181397
131short-chain fatty acid metabolic process (GO:0046459)2.59797057
132fatty acid oxidation (GO:0019395)2.59588101
133alpha-amino acid catabolic process (GO:1901606)2.59341357
134DNA deamination (GO:0045006)2.59284498
135rRNA metabolic process (GO:0016072)2.58447679
136regulation of cellular amino acid metabolic process (GO:0006521)2.58026557
137tRNA metabolic process (GO:0006399)2.57468808
138transcription elongation from RNA polymerase I promoter (GO:0006362)2.56841899
139cell fate commitment involved in formation of primary germ layer (GO:0060795)2.56783164
140drug transmembrane transport (GO:0006855)2.56225073
141protein localization to mitochondrion (GO:0070585)2.55819698
142regulation of helicase activity (GO:0051095)2.54843678
143tRNA processing (GO:0008033)2.54579489
1447-methylguanosine mRNA capping (GO:0006370)2.53682480
145establishment of protein localization to mitochondrion (GO:0072655)2.53644025
146monocarboxylic acid catabolic process (GO:0072329)2.53199441
147RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.51751019
148dopamine transport (GO:0015872)2.51708507
149ketone body metabolic process (GO:1902224)2.51170589
150axonemal dynein complex assembly (GO:0070286)2.50777009
151anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.50763292
152heart contraction (GO:0060047)2.50605110
153heart process (GO:0003015)2.50605110
154presynaptic membrane organization (GO:0097090)2.50531874
155termination of RNA polymerase I transcription (GO:0006363)2.50478734
156tRNA aminoacylation (GO:0043039)2.50113907
157amino acid activation (GO:0043038)2.50113907
158androgen biosynthetic process (GO:0006702)2.49315852
159negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.48865480
160negative regulation of ligase activity (GO:0051352)2.48865480
161DNA catabolic process, exonucleolytic (GO:0000738)2.48196573
162cell wall macromolecule catabolic process (GO:0016998)2.46693870
163cell wall macromolecule metabolic process (GO:0044036)2.46693870
1647-methylguanosine RNA capping (GO:0009452)2.46693050
165RNA capping (GO:0036260)2.46693050
166tRNA aminoacylation for protein translation (GO:0006418)2.46468453
167oxidative phosphorylation (GO:0006119)2.46255555
168phospholipid efflux (GO:0033700)2.46059155
169coenzyme catabolic process (GO:0009109)2.45851541
170sperm motility (GO:0030317)2.45700764
171aldehyde catabolic process (GO:0046185)2.45600100
172positive regulation of cellular amide metabolic process (GO:0034250)2.45146472
173ncRNA metabolic process (GO:0034660)2.44629372
174ATP biosynthetic process (GO:0006754)2.42085661
175multicellular organism reproduction (GO:0032504)2.42069662
176regulation of triglyceride catabolic process (GO:0010896)2.41867026
177disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.41661860
178killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.41661860
179nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.41584396
180viral life cycle (GO:0019058)2.41429286
181purine nucleoside triphosphate biosynthetic process (GO:0009145)2.40674108
182metallo-sulfur cluster assembly (GO:0031163)2.40309936
183iron-sulfur cluster assembly (GO:0016226)2.40309936
184developmental pigmentation (GO:0048066)2.39708228
185imidazole-containing compound metabolic process (GO:0052803)2.39680919
186organic acid catabolic process (GO:0016054)2.38029678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.38008971
2GBX2_23144817_ChIP-Seq_PC3_Human3.32229347
3EGR1_23403033_ChIP-Seq_LIVER_Mouse3.14858953
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.12677494
5ETS1_20019798_ChIP-Seq_JURKAT_Human2.95632419
6CREB1_15753290_ChIP-ChIP_HEK293T_Human2.88603475
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.83863660
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.82898649
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.82281240
10ELK1_19687146_ChIP-ChIP_HELA_Human2.77937973
11ZNF274_21170338_ChIP-Seq_K562_Hela2.63067144
12TAF15_26573619_Chip-Seq_HEK293_Human2.61744870
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.54403704
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.50372721
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.48785871
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.45993523
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.42591547
18* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39264417
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.38961619
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.36172512
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.35096191
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29009524
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.24404071
24* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19981833
25VDR_23849224_ChIP-Seq_CD4+_Human2.17958096
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15912398
27SRF_21415370_ChIP-Seq_HL-1_Mouse2.14863382
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.09764684
29IRF1_19129219_ChIP-ChIP_H3396_Human2.04898822
30SUZ12_27294783_Chip-Seq_NPCs_Mouse2.03761471
31NFE2_27457419_Chip-Seq_LIVER_Mouse2.02909989
32CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.01594383
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.99612761
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95954379
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91165669
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.89828007
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.86554842
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.85583809
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84124743
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.83022891
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79890278
42* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79354894
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.74605166
44* TTF2_22483619_ChIP-Seq_HELA_Human1.71782093
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.71034936
46* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.67449961
47DCP1A_22483619_ChIP-Seq_HELA_Human1.67170636
48IGF1R_20145208_ChIP-Seq_DFB_Human1.67124311
49* GABP_19822575_ChIP-Seq_HepG2_Human1.66812173
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65454694
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65422959
52RUNX1_27457419_Chip-Seq_LIVER_Mouse1.64247979
53MYC_18940864_ChIP-ChIP_HL60_Human1.63091220
54P53_22387025_ChIP-Seq_ESCs_Mouse1.62548276
55STAT3_18555785_Chip-Seq_ESCs_Mouse1.59866794
56E2F7_22180533_ChIP-Seq_HELA_Human1.58339476
57VDR_22108803_ChIP-Seq_LS180_Human1.57570104
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.57279416
59SUZ12_18555785_Chip-Seq_ESCs_Mouse1.56719300
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.55986218
61* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55146042
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54985047
63EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.53263154
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.52489822
65FUS_26573619_Chip-Seq_HEK293_Human1.50797393
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48063529
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.46367616
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45805559
69HTT_18923047_ChIP-ChIP_STHdh_Human1.45283396
70P300_18555785_Chip-Seq_ESCs_Mouse1.44892347
71TAL1_26923725_Chip-Seq_HPCs_Mouse1.43830412
72P300_19829295_ChIP-Seq_ESCs_Human1.42834055
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.42739348
74OCT4_18555785_Chip-Seq_ESCs_Mouse1.42223053
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41970567
76KAP1_22055183_ChIP-Seq_ESCs_Mouse1.41275839
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.41125567
78XRN2_22483619_ChIP-Seq_HELA_Human1.40633263
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.37771397
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.37509725
81NMYC_18555785_Chip-Seq_ESCs_Mouse1.36548190
82SOX2_18555785_Chip-Seq_ESCs_Mouse1.35437339
83* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35282455
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35076894
85SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.34084047
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32121346
87ZFX_18555785_Chip-Seq_ESCs_Mouse1.31556232
88PU1_27457419_Chip-Seq_LIVER_Mouse1.30861249
89KLF4_18555785_Chip-Seq_ESCs_Mouse1.30244839
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28488453
91YY1_21170310_ChIP-Seq_MESCs_Mouse1.26547863
92IRF8_22096565_ChIP-ChIP_GC-B_Human1.26530329
93ESRRB_18555785_Chip-Seq_ESCs_Mouse1.24894837
94RXR_22158963_ChIP-Seq_LIVER_Mouse1.24845552
95SMAD1_18555785_Chip-Seq_ESCs_Mouse1.24717535
96OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23988271
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23737561
98POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23706917
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.22605081
100MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22479135
101EZH2_22144423_ChIP-Seq_EOC_Human1.22206910
102FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22066915
103CTCF_18555785_Chip-Seq_ESCs_Mouse1.20975908
104POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19772706
105SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19591753
106ER_23166858_ChIP-Seq_MCF-7_Human1.19288932
107ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18876206
108HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18235477
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17643967
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17636447
111FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17251647
112TP53_22573176_ChIP-Seq_HFKS_Human1.17135779
113EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15985071
114EWS_26573619_Chip-Seq_HEK293_Human1.15414133
115* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15283805
116EST1_17652178_ChIP-ChIP_JURKAT_Human1.14633104
117KDM5A_27292631_Chip-Seq_BREAST_Human1.14037402
118STAT1_17558387_ChIP-Seq_HELA_Human1.13301501
119MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12669387
120FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09014470
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09001502
122EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08915425
123E2F1_21310950_ChIP-Seq_MCF-7_Human1.08581527
124AR_21909140_ChIP-Seq_LNCAP_Human1.06059853
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05198947
126CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05173203
127MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04961489
128CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03417149
129MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03158571
130LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02361424
131CBX2_27304074_Chip-Seq_ESCs_Mouse0.99384905
132LXR_22158963_ChIP-Seq_LIVER_Mouse0.99136956
133HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99025780
134CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98157484
135PPARA_22158963_ChIP-Seq_LIVER_Mouse0.96261357
136* FOXP3_21729870_ChIP-Seq_TREG_Human0.95837785
137* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95010043
138SOX2_16153702_ChIP-ChIP_HESCs_Human0.94080430
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93211415
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93211415
141POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91232242
142AR_20517297_ChIP-Seq_VCAP_Human0.90784960
143UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90265002
144KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89428866
145NANOG_16153702_ChIP-ChIP_HESCs_Human0.89061252
146KDM2B_26808549_Chip-Seq_REH_Human0.88405079
147RNF2_27304074_Chip-Seq_NSC_Mouse0.88218495
148SMAD4_21799915_ChIP-Seq_A2780_Human0.87909207
149BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87901482
150FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87383644
151ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86828645
152PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85752687
153* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84547000
154SOX17_20123909_ChIP-Seq_XEN_Mouse0.82427583
155SOX2_19829295_ChIP-Seq_ESCs_Human0.80098125
156NANOG_19829295_ChIP-Seq_ESCs_Human0.80098125
157FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78780950

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.53198635
2MP0005360_urolithiasis3.37782930
3MP0009697_abnormal_copulation2.91570847
4MP0005365_abnormal_bile_salt2.85607227
5MP0000015_abnormal_ear_pigmentation2.72239690
6MP0005075_abnormal_melanosome_morpholog2.58446154
7MP0008875_abnormal_xenobiotic_pharmacok2.57245846
8MP0005085_abnormal_gallbladder_physiolo2.54615184
9MP0003693_abnormal_embryo_hatching2.41578251
10MP0003646_muscle_fatigue2.40494022
11MP0004957_abnormal_blastocyst_morpholog2.33902605
12MP0003806_abnormal_nucleotide_metabolis2.30224799
13MP0005646_abnormal_pituitary_gland2.24083241
14MP0003718_maternal_effect2.23281923
15MP0006292_abnormal_olfactory_placode2.19619975
16MP0006036_abnormal_mitochondrial_physio2.19556338
17MP0005409_darkened_coat_color2.17756945
18MP0005410_abnormal_fertilization2.12614783
19MP0002876_abnormal_thyroid_physiology2.09440814
20MP0002938_white_spotting2.03984432
21MP0001188_hyperpigmentation2.01745097
22MP0004147_increased_porphyrin_level1.98645984
23MP0001293_anophthalmia1.94299008
24MP0005171_absent_coat_pigmentation1.89997107
25MP0001764_abnormal_homeostasis1.89608597
26MP0003880_abnormal_central_pattern1.86858439
27MP0005174_abnormal_tail_pigmentation1.86409526
28MP0003186_abnormal_redox_activity1.85210990
29MP0005332_abnormal_amino_acid1.84091341
30MP0001986_abnormal_taste_sensitivity1.81613621
31MP0008058_abnormal_DNA_repair1.80308186
32MP0000566_synostosis1.78205124
33MP0003890_abnormal_embryonic-extraembry1.76805284
34MP0005451_abnormal_body_composition1.73131390
35MP0005670_abnormal_white_adipose1.68521554
36MP0002132_abnormal_respiratory_system1.66796435
37MP0001529_abnormal_vocalization1.62031855
38MP0008260_abnormal_autophagy1.61303351
39MP0004381_abnormal_hair_follicle1.57925317
40MP0004133_heterotaxia1.56356609
41MP0002160_abnormal_reproductive_system1.55954382
42MP0001984_abnormal_olfaction1.53699818
43MP0004019_abnormal_vitamin_homeostasis1.53183313
44MP0008057_abnormal_DNA_replication1.51008424
45MP0008932_abnormal_embryonic_tissue1.48751130
46MP0000749_muscle_degeneration1.46399608
47MP0003122_maternal_imprinting1.41003207
48MP0006072_abnormal_retinal_apoptosis1.39028463
49MP0003123_paternal_imprinting1.36479899
50MP0003011_delayed_dark_adaptation1.35860914
51MP0004142_abnormal_muscle_tone1.34317129
52MP0003121_genomic_imprinting1.33068149
53MP0003567_abnormal_fetal_cardiomyocyte1.32165408
54MP0006035_abnormal_mitochondrial_morpho1.30244905
55MP0002233_abnormal_nose_morphology1.29689583
56MP0002751_abnormal_autonomic_nervous1.29046865
57MP0005408_hypopigmentation1.27401657
58MP0003195_calcinosis1.27194546
59MP0002210_abnormal_sex_determination1.26867002
60MP0003937_abnormal_limbs/digits/tail_de1.26551826
61MP0002095_abnormal_skin_pigmentation1.26390440
62MP0008995_early_reproductive_senescence1.25723939
63MP0003077_abnormal_cell_cycle1.25058007
64MP0003136_yellow_coat_color1.24230288
65MP0010329_abnormal_lipoprotein_level1.23556356
66MP0003111_abnormal_nucleus_morphology1.22831334
67MP0005647_abnormal_sex_gland1.22751068
68MP0003787_abnormal_imprinting1.22068920
69MP0000538_abnormal_urinary_bladder1.20595967
70MP0010030_abnormal_orbit_morphology1.18813848
71MP0005253_abnormal_eye_physiology1.14928234
72MP0008877_abnormal_DNA_methylation1.14032888
73MP0002396_abnormal_hematopoietic_system1.13039602
74MP0000427_abnormal_hair_cycle1.12390772
75MP0010094_abnormal_chromosome_stability1.11806873
76MP0005379_endocrine/exocrine_gland_phen1.11615394
77MP0005584_abnormal_enzyme/coenzyme_acti1.11163674
78MP0002163_abnormal_gland_morphology1.10486975
79MP0009764_decreased_sensitivity_to1.10329904
80MP0006276_abnormal_autonomic_nervous1.09108504
81MP0005389_reproductive_system_phenotype1.08709337
82MP0005645_abnormal_hypothalamus_physiol1.08399919
83MP0005084_abnormal_gallbladder_morpholo1.07940042
84MP0001324_abnormal_eye_pigmentation1.07790405
85MP0005187_abnormal_penis_morphology1.07064448
86MP0005551_abnormal_eye_electrophysiolog1.06166531
87MP0000653_abnormal_sex_gland1.05234899
88MP0002837_dystrophic_cardiac_calcinosis1.05195476
89MP0003119_abnormal_digestive_system1.04360891
90MP0003315_abnormal_perineum_morphology1.03227001
91MP0005423_abnormal_somatic_nervous1.02292269
92MP0000647_abnormal_sebaceous_gland1.02287532
93MP0003656_abnormal_erythrocyte_physiolo1.01935318
94MP0003698_abnormal_male_reproductive1.01918075
95MP0001835_abnormal_antigen_presentation1.01689259
96MP0001853_heart_inflammation1.00549920
97MP0001145_abnormal_male_reproductive0.99508260
98MP0000358_abnormal_cell_content/0.98199593
99MP0004215_abnormal_myocardial_fiber0.97500015
100MP0003252_abnormal_bile_duct0.96705390
101MP0002736_abnormal_nociception_after0.96075117
102MP0003724_increased_susceptibility_to0.96046805
103MP0002102_abnormal_ear_morphology0.94703818
104MP0001661_extended_life_span0.94567439
105MP0005636_abnormal_mineral_homeostasis0.92858824
106MP0002234_abnormal_pharynx_morphology0.92780008
107MP0001286_abnormal_eye_development0.92215617
108MP0003942_abnormal_urinary_system0.92094462
109MP0002090_abnormal_vision0.91683447
110MP0009379_abnormal_foot_pigmentation0.91445025
111MP0000462_abnormal_digestive_system0.90525962
112MP0005319_abnormal_enzyme/_coenzyme0.90273123
113MP0001968_abnormal_touch/_nociception0.90118173
114MP0001929_abnormal_gametogenesis0.89503354
115MP0001963_abnormal_hearing_physiology0.88811026
116MP0005391_vision/eye_phenotype0.88654557
117MP0008007_abnormal_cellular_replicative0.87828658
118MP0004145_abnormal_muscle_electrophysio0.87472932
119MP0001119_abnormal_female_reproductive0.86281644
120MP0003172_abnormal_lysosome_physiology0.86206171
121MP0003941_abnormal_skin_development0.86144283
122MP0008872_abnormal_physiological_respon0.85540205
123MP0001666_abnormal_nutrient_absorption0.84941852
124MP0002638_abnormal_pupillary_reflex0.83959494
125MP0002084_abnormal_developmental_patter0.82872204
126MP0000631_abnormal_neuroendocrine_gland0.82720247
127MP0000372_irregular_coat_pigmentation0.82325436
128MP0002118_abnormal_lipid_homeostasis0.81077885
129MP0003936_abnormal_reproductive_system0.81063393
130MP0001486_abnormal_startle_reflex0.80990729
131MP0005266_abnormal_metabolism0.80441931
132MP0003950_abnormal_plasma_membrane0.80246850
133MP0000751_myopathy0.79752334
134MP0000049_abnormal_middle_ear0.79715359
135MP0005377_hearing/vestibular/ear_phenot0.78541656
136MP0003878_abnormal_ear_physiology0.78541656
137MP0003137_abnormal_impulse_conducting0.78154317
138MP0004782_abnormal_surfactant_physiolog0.78138566
139MP0003786_premature_aging0.77407463
140MP0002127_abnormal_cardiovascular_syste0.76960965
141MP0003191_abnormal_cellular_cholesterol0.76006215
142MP0003868_abnormal_feces_composition0.74965067
143MP0009643_abnormal_urine_homeostasis0.74433338
144MP0004043_abnormal_pH_regulation0.71412789
145MP0001186_pigmentation_phenotype0.70962938
146MP0002148_abnormal_hypersensitivity_rea0.70316174
147MP0005671_abnormal_response_to0.69532631
148MP0009840_abnormal_foam_cell0.69203742
149MP0003763_abnormal_thymus_physiology0.66846654
150MP0002075_abnormal_coat/hair_pigmentati0.66805521
151MP0008469_abnormal_protein_level0.66297689
152MP0001905_abnormal_dopamine_level0.65917825
153MP0002229_neurodegeneration0.65029880
154MP0000609_abnormal_liver_physiology0.64981634
155MP0000026_abnormal_inner_ear0.64658390

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.52910406
2Renal cortical cysts (HP:0000803)3.49115228
3Hepatic necrosis (HP:0002605)3.47606291
4Acute encephalopathy (HP:0006846)3.46046813
5Hepatocellular necrosis (HP:0001404)3.40555267
6Abnormal mitochondria in muscle tissue (HP:0008316)3.35603290
7Mitochondrial inheritance (HP:0001427)3.33830287
8* Increased CSF lactate (HP:0002490)3.10869512
9Increased serum pyruvate (HP:0003542)3.01222487
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.94848327
11Chronic hepatic failure (HP:0100626)2.93920768
12Cerebral edema (HP:0002181)2.88514427
13Generalized aminoaciduria (HP:0002909)2.86262939
14Abnormality of methionine metabolism (HP:0010901)2.82898679
15Progressive macrocephaly (HP:0004481)2.82235519
16Lipid accumulation in hepatocytes (HP:0006561)2.81239091
17Hyperglycinuria (HP:0003108)2.80471760
18Tubulointerstitial nephritis (HP:0001970)2.78477238
19Reduced antithrombin III activity (HP:0001976)2.76959051
20Type I transferrin isoform profile (HP:0003642)2.74794349
21Increased hepatocellular lipid droplets (HP:0006565)2.71692529
22Abnormality of dicarboxylic acid metabolism (HP:0010995)2.70630624
23Dicarboxylic aciduria (HP:0003215)2.70630624
24* Lactic acidosis (HP:0003128)2.70146599
25Renal Fanconi syndrome (HP:0001994)2.68534826
26Abnormality of fatty-acid metabolism (HP:0004359)2.68363783
27Prolonged partial thromboplastin time (HP:0003645)2.68221953
28Chromsome breakage (HP:0040012)2.68053061
29Macrocytic anemia (HP:0001972)2.67774647
30Abnormality of aspartate family amino acid metabolism (HP:0010899)2.67386959
31Absent/shortened dynein arms (HP:0200106)2.66670703
32Dynein arm defect of respiratory motile cilia (HP:0012255)2.66670703
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.66332067
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.66332067
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.64479993
36Reticulocytopenia (HP:0001896)2.61389495
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60554156
38Pancreatic cysts (HP:0001737)2.58185404
39Abnormal number of erythroid precursors (HP:0012131)2.57844918
40Abnormality of glycolysis (HP:0004366)2.57609175
41Abnormality of renal resorption (HP:0011038)2.52370373
42Abnormality of midbrain morphology (HP:0002418)2.51403246
43Molar tooth sign on MRI (HP:0002419)2.51403246
44Methylmalonic acidemia (HP:0002912)2.49823328
45Abnormality of cells of the erythroid lineage (HP:0012130)2.47274969
46Gait imbalance (HP:0002141)2.46313071
47Abnormality of alanine metabolism (HP:0010916)2.45935899
48Hyperalaninemia (HP:0003348)2.45935899
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.45935899
503-Methylglutaconic aciduria (HP:0003535)2.43728513
51Microvesicular hepatic steatosis (HP:0001414)2.42383205
52* Increased serum lactate (HP:0002151)2.40161457
53Abnormality of the renal collecting system (HP:0004742)2.39238911
54Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.38465461
55Intrahepatic cholestasis (HP:0001406)2.38348546
56Abnormality of serum amino acid levels (HP:0003112)2.37825540
57Congenital primary aphakia (HP:0007707)2.37352072
58Increased muscle lipid content (HP:0009058)2.36697420
59Abnormality of pyrimidine metabolism (HP:0004353)2.36643584
60Exercise intolerance (HP:0003546)2.36168109
61Nephronophthisis (HP:0000090)2.35537957
62Increased intramyocellular lipid droplets (HP:0012240)2.34774428
63Joint hemorrhage (HP:0005261)2.33827940
64Glycosuria (HP:0003076)2.31517023
65Abnormality of urine glucose concentration (HP:0011016)2.31517023
66Optic disc pallor (HP:0000543)2.30738083
67Abnormality of serine family amino acid metabolism (HP:0010894)2.28100266
68Abnormality of glycine metabolism (HP:0010895)2.28100266
69Abnormality of the renal cortex (HP:0011035)2.28013419
70Pancreatic fibrosis (HP:0100732)2.27881419
71Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.27338765
72Nephrogenic diabetes insipidus (HP:0009806)2.26692861
73Methylmalonic aciduria (HP:0012120)2.26184052
74Abnormality of the labia minora (HP:0012880)2.25367436
75Congenital stationary night blindness (HP:0007642)2.25191367
76Hyperglycinemia (HP:0002154)2.24095999
77Abnormal respiratory motile cilium physiology (HP:0012261)2.22209071
78* Lethargy (HP:0001254)2.19528178
79Abnormal ciliary motility (HP:0012262)2.19517171
80Bile duct proliferation (HP:0001408)2.19289036
81Abnormal biliary tract physiology (HP:0012439)2.19289036
82Abnormal respiratory motile cilium morphology (HP:0005938)2.18937790
83Abnormal respiratory epithelium morphology (HP:0012253)2.18937790
84Patchy hypopigmentation of hair (HP:0011365)2.17696749
85True hermaphroditism (HP:0010459)2.17418208
86Abnormality of aromatic amino acid family metabolism (HP:0004338)2.16624755
87Type II lissencephaly (HP:0007260)2.15237585
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15097901
89Abnormal protein N-linked glycosylation (HP:0012347)2.15097901
90Abnormal protein glycosylation (HP:0012346)2.15097901
91Abnormal glycosylation (HP:0012345)2.15097901
92Hypoplasia of the pons (HP:0012110)2.12617039
93Hyperammonemia (HP:0001987)2.12441361
94White forelock (HP:0002211)2.11699589
95Decreased central vision (HP:0007663)2.10550221
96Abnormal hair whorl (HP:0010721)2.10192095
97Meckel diverticulum (HP:0002245)2.08950689
98Hypobetalipoproteinemia (HP:0003563)2.05493652
99Genital tract atresia (HP:0001827)2.05390930
100Respiratory failure (HP:0002878)2.04854097
101Abnormality of the vitamin B12 metabolism (HP:0004341)2.03755435
102Metabolic acidosis (HP:0001942)2.03734133
103Abnormality of the ileum (HP:0001549)2.03001774
104Severe visual impairment (HP:0001141)2.01170618
105Vaginal atresia (HP:0000148)2.00853597
106Cerebellar dysplasia (HP:0007033)2.00701457
107Abnormality of vitamin B metabolism (HP:0004340)1.97978215
108Duplicated collecting system (HP:0000081)1.97934841
109Abnormality of lateral ventricle (HP:0030047)1.97126361
110Delayed CNS myelination (HP:0002188)1.97112633
111Intestinal atresia (HP:0011100)1.96658860
112Proximal tubulopathy (HP:0000114)1.96190409
113Leukodystrophy (HP:0002415)1.96002461
114Hyperphosphaturia (HP:0003109)1.95784931
115Abnormality of secondary sexual hair (HP:0009888)1.95572703
116Abnormality of the axillary hair (HP:0100134)1.95572703
117Abnormality of the pons (HP:0007361)1.95134660
118Postaxial foot polydactyly (HP:0001830)1.94788389
119Aplasia/Hypoplasia of the uvula (HP:0010293)1.92289480
120Hypoglycemic coma (HP:0001325)1.91823893
121Conjugated hyperbilirubinemia (HP:0002908)1.91099763
122Ketosis (HP:0001946)1.89912516
123Abnormality of the heme biosynthetic pathway (HP:0010472)1.88126944
124Poor coordination (HP:0002370)1.87364962
125Cerebral palsy (HP:0100021)1.87114864
126Abnormal pancreas size (HP:0012094)1.86284715
127Pancytopenia (HP:0001876)1.85895128
128Volvulus (HP:0002580)1.85148173
129Opisthotonus (HP:0002179)1.84664706
130Respiratory difficulties (HP:0002880)1.84597069
131CNS demyelination (HP:0007305)1.84246742
132Abnormality of chromosome stability (HP:0003220)1.84150093
133Hypothermia (HP:0002045)1.80782675
134Supernumerary spleens (HP:0009799)1.80167135
135Megaloblastic anemia (HP:0001889)1.78368343
136Hyperbilirubinemia (HP:0002904)1.78350207
137Abnormality of the renal medulla (HP:0100957)1.78338764
138Medial flaring of the eyebrow (HP:0010747)1.77856941
139Colon cancer (HP:0003003)1.77498312
140Concave nail (HP:0001598)1.77325604
141Hyperinsulinemic hypoglycemia (HP:0000825)1.76500521
142Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76410976
143Gonadotropin excess (HP:0000837)1.75981069
144Congenital hepatic fibrosis (HP:0002612)1.75833398
145Rib fusion (HP:0000902)1.75006376
146Poor suck (HP:0002033)1.74922568
147Bifid tongue (HP:0010297)1.72624836
148Aplasia/Hypoplasia of the tongue (HP:0010295)1.72489102

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.80829178
2STK163.79458963
3INSRR3.42146718
4TNIK3.23529413
5PBK3.01327350
6BUB12.70851175
7PNCK2.46976957
8TRIM282.39217241
9ZAK2.37242197
10MKNK22.15663615
11CDC72.04248641
12VRK22.01426620
13MAP4K21.97488006
14PDK41.90460599
15PDK31.90460599
16OBSCN1.88573278
17TGFBR11.84974515
18IRAK41.83200873
19NME11.69838421
20SIK31.69011081
21MAP2K71.68639317
22EIF2AK21.68022605
23IRAK31.64648468
24SGK21.64021420
25TXK1.63689387
26MAP3K141.63471770
27PLK31.63366311
28MKNK11.58293667
29PINK11.57147561
30BCKDK1.54351457
31GRK11.49420728
32TTK1.42765370
33GRK71.42063147
34MST41.40893949
35SRPK11.38534497
36TEC1.37472477
37ADRBK21.35857318
38EIF2AK31.35633272
39YES11.34557328
40FRK1.33694268
41CCNB11.33578978
42MUSK1.32807202
43PRPF4B1.28453298
44MYLK1.27270318
45OXSR11.26334169
46PLK11.26282492
47PDK21.23307608
48CDK191.15219863
49FLT31.13730961
50NEK61.13335062
51MAP3K41.12994333
52VRK11.11004964
53DYRK21.10849290
54MAP3K121.07880582
55TLK11.07779077
56BCR1.01182219
57BRSK21.00286268
58MAPK130.99985671
59PKN10.98181248
60SGK4940.95883324
61SGK2230.95883324
62PRKCG0.92520460
63PASK0.91180221
64CDK30.88857274
65CDK80.88721513
66TAOK20.87634074
67AKT30.86453289
68NEK10.86295683
69KIT0.83888812
70TAF10.83376640
71EIF2AK10.79702733
72BLK0.79669920
73ATR0.79429240
74SGK30.78495906
75BTK0.78400572
76CLK10.78277978
77TRPM70.76842763
78ATM0.75185358
79BRSK10.75037537
80STK30.73328061
81IKBKE0.72920659
82CSF1R0.72825233
83CDK70.72378936
84CSNK1G10.72276736
85PLK40.71380485
86BMPR20.71221508
87PLK20.71116264
88CSNK2A20.70725089
89TAOK30.69090621
90STK390.68932982
91PIK3CA0.68907570
92MAPKAPK50.67587269
93MARK10.65716474
94RPS6KB20.65530616
95MAPK70.65521408
96MAPK120.64052440
97AURKB0.63003900
98CSNK1E0.62826046
99IRAK10.62763717
100EPHA40.62707817
101CSNK1G30.62228129
102BMPR1B0.62129219
103FGFR10.61276050
104CSNK1G20.59745836
105TIE10.59446636
106PHKG10.58628251
107PHKG20.58628251
108TNK20.58142899
109NEK90.57742651
110ACVR1B0.56077088
111WNK40.56036038
112BRAF0.55281152
113STK38L0.54701070
114PRKCI0.53248594
115NEK20.52999407
116NME20.52996353
117CHEK10.51145123
118RPS6KA50.49682190
119PRKAA20.49072105
120RPS6KB10.48185894
121CDK90.47559894
122SYK0.47164004
123DAPK10.47010013
124LYN0.46649067
125TGFBR20.46584210
126PIK3CG0.46375560
127BRD40.46328212
128AURKA0.45901636
129WNK30.45780863
130STK240.45572827
131NLK0.45301835
132WEE10.44229443
133PAK30.44197533
134ILK0.44044849
135FES0.43481004
136MAPK110.40578957
137PRKACB0.38869126
138NUAK10.38071340
139PRKCQ0.37109735
140PRKG10.36960675
141CSNK2A10.36890413
142STK40.36556238
143PRKACA0.36414678
144LIMK10.35077665
145MAPK40.34485028
146TSSK60.34396279
147CHEK20.34028380
148CSNK1A10.33787852
149RPS6KA60.33494106
150PRKCE0.33248970
151ERBB30.33200887
152IKBKB0.32575521
153ERBB40.32429439
154PKN20.32316406

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.17030556
2Propanoate metabolism_Homo sapiens_hsa006402.81850464
3Fatty acid degradation_Homo sapiens_hsa000712.53088845
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.43653350
5Peroxisome_Homo sapiens_hsa041462.31900499
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.20850749
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18435828
8Oxidative phosphorylation_Homo sapiens_hsa001902.12642605
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.02384635
10Non-homologous end-joining_Homo sapiens_hsa034501.98917586
11Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.98567389
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.98432430
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.92723436
14Fatty acid metabolism_Homo sapiens_hsa012121.87374550
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.86364304
16Fatty acid elongation_Homo sapiens_hsa000621.84827258
17beta-Alanine metabolism_Homo sapiens_hsa004101.80216723
18Pyruvate metabolism_Homo sapiens_hsa006201.79173108
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.75840274
20Tryptophan metabolism_Homo sapiens_hsa003801.74576312
21Homologous recombination_Homo sapiens_hsa034401.73742140
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70774732
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.67956408
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.62735622
25Parkinsons disease_Homo sapiens_hsa050121.60227436
26Fanconi anemia pathway_Homo sapiens_hsa034601.58179931
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.55968213
28Selenocompound metabolism_Homo sapiens_hsa004501.51010022
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.50701510
30RNA transport_Homo sapiens_hsa030131.48780394
31DNA replication_Homo sapiens_hsa030301.47215741
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46781833
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46696878
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.43939376
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42452240
36Butanoate metabolism_Homo sapiens_hsa006501.42256920
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40380992
38Carbon metabolism_Homo sapiens_hsa012001.39307441
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.33797044
40Histidine metabolism_Homo sapiens_hsa003401.31933620
41Starch and sucrose metabolism_Homo sapiens_hsa005001.31624978
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29821850
43Other glycan degradation_Homo sapiens_hsa005111.29009473
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.28059197
45Vitamin digestion and absorption_Homo sapiens_hsa049771.25390891
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24172194
47PPAR signaling pathway_Homo sapiens_hsa033201.22053009
48Huntingtons disease_Homo sapiens_hsa050161.21675655
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21628723
50Chemical carcinogenesis_Homo sapiens_hsa052041.19514481
51One carbon pool by folate_Homo sapiens_hsa006701.18787815
52Spliceosome_Homo sapiens_hsa030401.17235925
53Base excision repair_Homo sapiens_hsa034101.16889127
54Pyrimidine metabolism_Homo sapiens_hsa002401.15620928
55Mismatch repair_Homo sapiens_hsa034301.15616196
56ABC transporters_Homo sapiens_hsa020101.14916301
57Retinol metabolism_Homo sapiens_hsa008301.14208113
58Arachidonic acid metabolism_Homo sapiens_hsa005901.09973111
59Maturity onset diabetes of the young_Homo sapiens_hsa049501.09368910
60Alzheimers disease_Homo sapiens_hsa050101.08095111
61Complement and coagulation cascades_Homo sapiens_hsa046101.05337556
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03616140
63Purine metabolism_Homo sapiens_hsa002301.03116559
64Metabolic pathways_Homo sapiens_hsa011001.01195248
65Tyrosine metabolism_Homo sapiens_hsa003500.98504985
66Phenylalanine metabolism_Homo sapiens_hsa003600.98284596
67Sulfur metabolism_Homo sapiens_hsa009200.97326141
68Fat digestion and absorption_Homo sapiens_hsa049750.96894752
69Arginine and proline metabolism_Homo sapiens_hsa003300.96461952
70RNA polymerase_Homo sapiens_hsa030200.93758203
71Caffeine metabolism_Homo sapiens_hsa002320.90508876
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90335309
73Basal transcription factors_Homo sapiens_hsa030220.88299126
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87505964
75Fatty acid biosynthesis_Homo sapiens_hsa000610.87115937
76Lysine degradation_Homo sapiens_hsa003100.85705937
77Biosynthesis of amino acids_Homo sapiens_hsa012300.85246994
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85160783
79Arginine biosynthesis_Homo sapiens_hsa002200.83683976
80Linoleic acid metabolism_Homo sapiens_hsa005910.83511651
81Pentose phosphate pathway_Homo sapiens_hsa000300.79554632
82Nucleotide excision repair_Homo sapiens_hsa034200.79391198
83Sulfur relay system_Homo sapiens_hsa041220.78611988
84Cardiac muscle contraction_Homo sapiens_hsa042600.76373001
85Vitamin B6 metabolism_Homo sapiens_hsa007500.75382823
86Regulation of autophagy_Homo sapiens_hsa041400.74629515
87Cell cycle_Homo sapiens_hsa041100.71489323
88Protein export_Homo sapiens_hsa030600.71065916
89Glutathione metabolism_Homo sapiens_hsa004800.68611416
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67648406
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65930085
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65303496
93RNA degradation_Homo sapiens_hsa030180.62308818
94Proteasome_Homo sapiens_hsa030500.62065588
95Nitrogen metabolism_Homo sapiens_hsa009100.60680947
96Fructose and mannose metabolism_Homo sapiens_hsa000510.60603579
97Phototransduction_Homo sapiens_hsa047440.58688629
98p53 signaling pathway_Homo sapiens_hsa041150.57311970
99Folate biosynthesis_Homo sapiens_hsa007900.56617145
100Galactose metabolism_Homo sapiens_hsa000520.53661310
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52766665
102N-Glycan biosynthesis_Homo sapiens_hsa005100.49276479
103Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48781206
104Staphylococcus aureus infection_Homo sapiens_hsa051500.48696218
105Steroid biosynthesis_Homo sapiens_hsa001000.48334159
106Primary immunodeficiency_Homo sapiens_hsa053400.47246127
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.46670931
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46668460
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46521452
110TGF-beta signaling pathway_Homo sapiens_hsa043500.45465356
111mRNA surveillance pathway_Homo sapiens_hsa030150.44685689
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44552415
113Ether lipid metabolism_Homo sapiens_hsa005650.44194077
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.43396674
115Glycerolipid metabolism_Homo sapiens_hsa005610.42890215
116Collecting duct acid secretion_Homo sapiens_hsa049660.42844848
117Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37439687
118Oocyte meiosis_Homo sapiens_hsa041140.36453131
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.35941185
120Mineral absorption_Homo sapiens_hsa049780.35316792
121Hedgehog signaling pathway_Homo sapiens_hsa043400.29089071
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28462253
123Hippo signaling pathway_Homo sapiens_hsa043900.26300008
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26200673
125Basal cell carcinoma_Homo sapiens_hsa052170.25602669
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25035122

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