RNASE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcytosis (GO:0045056)8.66947158
2intestinal absorption (GO:0050892)7.93724136
3cholesterol catabolic process (GO:0006707)7.41822682
4sterol catabolic process (GO:0016127)7.41822682
5cobalamin metabolic process (GO:0009235)7.38067165
6peptidyl-proline hydroxylation (GO:0019511)6.86970508
7regulation of phospholipase A2 activity (GO:0032429)6.54202463
8Golgi transport vesicle coating (GO:0048200)6.52641856
9COPI coating of Golgi vesicle (GO:0048205)6.52641856
10negative regulation of digestive system process (GO:0060457)6.41798237
11glycolipid catabolic process (GO:0019377)6.16308275
12membrane lipid catabolic process (GO:0046466)6.06113335
13cysteine metabolic process (GO:0006534)5.75103408
14ceramide catabolic process (GO:0046514)5.43891293
15proline biosynthetic process (GO:0006561)5.38102134
16valine metabolic process (GO:0006573)5.36755230
17regulation of mononuclear cell migration (GO:0071675)5.31200003
18protein hydroxylation (GO:0018126)5.27154269
19activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.24446667
20negative regulation of interleukin-12 production (GO:0032695)5.23301851
21branched-chain amino acid catabolic process (GO:0009083)5.22424383
22positive regulation of nuclease activity (GO:0032075)5.00020584
23intestinal epithelial cell development (GO:0060576)4.87177380
24glycosphingolipid catabolic process (GO:0046479)4.75379341
25branched-chain amino acid metabolic process (GO:0009081)4.69207059
26endoplasmic reticulum unfolded protein response (GO:0030968)4.67931568
27cellular modified amino acid catabolic process (GO:0042219)4.67254238
28response to endoplasmic reticulum stress (GO:0034976)4.67179141
29protein maturation by protein folding (GO:0022417)4.61292860
30zinc ion transport (GO:0006829)4.61178409
31response to peptidoglycan (GO:0032494)4.54696710
32cellular response to unfolded protein (GO:0034620)4.54690503
33regulation of nuclease activity (GO:0032069)4.54464622
34neutrophil activation involved in immune response (GO:0002283)4.52693992
35oligosaccharide catabolic process (GO:0009313)4.46406224
36cellular response to thyroid hormone stimulus (GO:0097067)4.43736991
37mitochondrial calcium ion transport (GO:0006851)4.36085057
38amino sugar catabolic process (GO:0046348)4.33132567
39ER-nucleus signaling pathway (GO:0006984)4.32063670
40cellular response to topologically incorrect protein (GO:0035967)4.30350154
41COPII vesicle coating (GO:0048208)4.28857832
42homocysteine metabolic process (GO:0050667)4.28368636
43signal peptide processing (GO:0006465)4.23214468
44virion attachment to host cell (GO:0019062)4.16517124
45adhesion of symbiont to host cell (GO:0044650)4.16517124
46maintenance of protein localization in organelle (GO:0072595)4.16179114
47ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.09463124
48negative regulation of nitric oxide biosynthetic process (GO:0045019)4.05431161
49regulation of cytokine secretion involved in immune response (GO:0002739)4.02851021
50positive regulation of heat generation (GO:0031652)4.01729307
51macrophage activation involved in immune response (GO:0002281)4.00387457
524-hydroxyproline metabolic process (GO:0019471)3.99081685
53leukotriene biosynthetic process (GO:0019370)3.93447468
54endocrine pancreas development (GO:0031018)3.91606977
55lipopolysaccharide-mediated signaling pathway (GO:0031663)3.87833631
56glutamine metabolic process (GO:0006541)3.86554208
57regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.84583606
58N-acetylneuraminate metabolic process (GO:0006054)3.84423615
59positive regulation of chemokine biosynthetic process (GO:0045080)3.84335818
60T-helper 1 type immune response (GO:0042088)3.83699527
61regulation of macrophage chemotaxis (GO:0010758)3.83688702
62retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.83149973
63regulation of fever generation (GO:0031620)3.82497576
64monocyte chemotaxis (GO:0002548)3.82243371
65negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.80000598
66ER overload response (GO:0006983)3.79963342
67immunoglobulin mediated immune response (GO:0016064)3.78058817
68serine family amino acid biosynthetic process (GO:0009070)3.76711662
69regulation of vitamin D biosynthetic process (GO:0060556)3.76393591
70GDP-mannose metabolic process (GO:0019673)3.75489748
71aspartate family amino acid catabolic process (GO:0009068)3.73839595
72adhesion of symbiont to host (GO:0044406)3.71900914
73myeloid dendritic cell differentiation (GO:0043011)3.69452147
74response to unfolded protein (GO:0006986)3.68149864
75steroid catabolic process (GO:0006706)3.66865587
76proline metabolic process (GO:0006560)3.63633536
77regulation of podosome assembly (GO:0071801)3.62512174
78antibacterial humoral response (GO:0019731)3.61335481
79NIK/NF-kappaB signaling (GO:0038061)3.60783579
80protein N-linked glycosylation via asparagine (GO:0018279)3.55450904
81positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.53497379
82response to topologically incorrect protein (GO:0035966)3.53126602
83peptidyl-asparagine modification (GO:0018196)3.52847754
84neutrophil mediated immunity (GO:0002446)3.52550770
85negative regulation of cytokine production involved in immune response (GO:0002719)3.50061806
86barbed-end actin filament capping (GO:0051016)3.49809033
87sphingolipid catabolic process (GO:0030149)3.47778121
88response to thyroid hormone (GO:0097066)3.46296530
89creatine metabolic process (GO:0006600)3.45815184
90regulation of cholesterol storage (GO:0010885)3.38185795
91adenosine receptor signaling pathway (GO:0001973)3.36025936
92antimicrobial humoral response (GO:0019730)3.34111576
93regulation of membrane protein ectodomain proteolysis (GO:0051043)3.32071748
94low-density lipoprotein particle clearance (GO:0034383)3.31629590
95regulation of chemokine biosynthetic process (GO:0045073)3.30028980
96negative regulation of epidermal cell differentiation (GO:0045605)3.28825383
97eosinophil chemotaxis (GO:0048245)3.27875070
98coenzyme catabolic process (GO:0009109)3.27511837
99positive regulation of mast cell degranulation (GO:0043306)3.25295932
100positive regulation of mast cell activation involved in immune response (GO:0033008)3.25295932
101protein N-linked glycosylation (GO:0006487)3.23529665
102myeloid dendritic cell activation (GO:0001773)3.23162865
103positive regulation of monocyte chemotaxis (GO:0090026)3.20674333
104positive regulation of leukocyte degranulation (GO:0043302)3.20630188
105mitochondrion distribution (GO:0048311)3.20379298
106regulation of mast cell degranulation (GO:0043304)3.18152312
107erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.16992391
108L-phenylalanine catabolic process (GO:0006559)3.16992391
109cholesterol transport (GO:0030301)3.15838523
110sterol transport (GO:0015918)3.15838523
111L-alpha-amino acid transmembrane transport (GO:1902475)3.13978513
112granulocyte activation (GO:0036230)3.11830297
113arachidonic acid secretion (GO:0050482)3.10479831
114icosanoid secretion (GO:0032309)3.10479831
115cell redox homeostasis (GO:0045454)3.10081746
116regulation of heat generation (GO:0031650)3.07804388
117cellular response to arsenic-containing substance (GO:0071243)3.07551201
118branching involved in labyrinthine layer morphogenesis (GO:0060670)3.07474788
119positive regulation of antigen processing and presentation (GO:0002579)3.07085084
120interferon-gamma-mediated signaling pathway (GO:0060333)3.04414857
121negative regulation of myeloid cell apoptotic process (GO:0033033)3.02638130
122negative regulation of erythrocyte differentiation (GO:0045647)3.02062781
123positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.00017135
124dendritic cell differentiation (GO:0097028)2.99828599
125regulation of vitamin metabolic process (GO:0030656)2.99352741
126regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.98834864
127regulation of T-helper 1 cell differentiation (GO:0045625)2.98761062
128erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.96935161
129L-phenylalanine metabolic process (GO:0006558)2.96935161
130L-serine metabolic process (GO:0006563)2.96390827
131peptide catabolic process (GO:0043171)2.96143292
132macrophage activation (GO:0042116)2.92866224
133detection of molecule of bacterial origin (GO:0032490)2.92145003
134serine family amino acid metabolic process (GO:0009069)2.90881191
135positive regulation of mast cell activation (GO:0033005)2.90701750
136regulation of mast cell activation involved in immune response (GO:0033006)2.90260036
137digestive system process (GO:0022600)2.89227966
138negative regulation of production of molecular mediator of immune response (GO:0002701)2.88858995
139regulation of antigen processing and presentation (GO:0002577)2.88792646
140vesicle coating (GO:0006901)2.88735017
141eosinophil migration (GO:0072677)2.88389323
142UDP-N-acetylglucosamine metabolic process (GO:0006047)2.88188527
143pancreas development (GO:0031016)2.87315754
144cellular response to lipopolysaccharide (GO:0071222)2.87231830
145folic acid transport (GO:0015884)2.87228661
146regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.86956478
147germinal center formation (GO:0002467)2.85991481
148negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.85364766
149positive regulation by symbiont of host defense response (GO:0052509)2.84427562
150modulation by symbiont of host defense response (GO:0052031)2.84427562
151modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.84427562
152modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.84427562
153positive regulation by organism of defense response of other organism involved in symbiotic interact2.84427562
154modulation by symbiont of host immune response (GO:0052553)2.84427562
155biotin metabolic process (GO:0006768)2.83079237
156response to acidic pH (GO:0010447)2.82933272
157regulation of chronic inflammatory response (GO:0002676)2.81342976
158regulation of interferon-alpha production (GO:0032647)2.81319606
159regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.80989175
160positive regulation of gamma-delta T cell activation (GO:0046645)2.80371403
161response to protozoan (GO:0001562)2.79753294
162macrophage differentiation (GO:0030225)2.79266163
163positive regulation of smooth muscle cell migration (GO:0014911)2.78866353
164regulation of nitric oxide biosynthetic process (GO:0045428)2.77774016
165polarized epithelial cell differentiation (GO:0030859)2.77243685
166lung secretory cell differentiation (GO:0061140)2.76816126
167Golgi organization (GO:0007030)2.76753028
168cellular response to molecule of bacterial origin (GO:0071219)2.76625362
169positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.76562814
170regulation of leukocyte degranulation (GO:0043300)2.75431417
171regulation of digestive system process (GO:0044058)2.73156104
172positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.72982741
173regulation of monocyte chemotaxis (GO:0090025)2.72682618
174negative regulation of cell fate commitment (GO:0010454)2.72078511
175regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)2.71921286
176myeloid cell activation involved in immune response (GO:0002275)2.71663765
177histamine secretion (GO:0001821)2.71150359
178keratan sulfate catabolic process (GO:0042340)2.70620727
179nucleotide-sugar biosynthetic process (GO:0009226)2.69242199
180regulation of inflammatory response to antigenic stimulus (GO:0002861)2.68699103
181myeloid leukocyte mediated immunity (GO:0002444)2.67255409
182negative regulation of granulocyte differentiation (GO:0030853)2.66989590
183mature B cell differentiation involved in immune response (GO:0002313)2.65427469
184positive regulation of cholesterol efflux (GO:0010875)2.64892499
185regulation of T-helper 2 cell differentiation (GO:0045628)2.64827542
186innate immune response in mucosa (GO:0002227)2.62470796
187sulfur amino acid catabolic process (GO:0000098)2.62364465
188regulation of oxidative stress-induced cell death (GO:1903201)2.59165759
189intestinal cholesterol absorption (GO:0030299)17.7409762
190exocrine pancreas development (GO:0031017)15.9162104
191digestion (GO:0007586)13.2726293
192protein retention in ER lumen (GO:0006621)12.2196259
193maintenance of protein localization in endoplasmic reticulum (GO:0035437)11.5693614

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.90482703
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.93807489
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.92407342
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.40547049
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human4.36974483
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.89771664
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.75863410
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.63663543
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.49295637
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.14289861
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.09613470
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.91307509
13ERG_21242973_ChIP-ChIP_JURKAT_Human2.87924581
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.81406955
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.81309937
16SOX2_27498859_Chip-Seq_STOMACH_Mouse2.79264413
17ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.65954631
18RXR_22158963_ChIP-Seq_LIVER_Mouse2.60608690
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.60450471
20* GATA4_25053715_ChIP-Seq_YYC3_Human2.55407292
21GATA1_22025678_ChIP-Seq_K562_Human2.54675233
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.41826135
23ESR1_21235772_ChIP-Seq_MCF-7_Human2.38679827
24LXR_22158963_ChIP-Seq_LIVER_Mouse2.37100656
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.30920032
26VDR_21846776_ChIP-Seq_THP-1_Human2.27468715
27ESR2_21235772_ChIP-Seq_MCF-7_Human2.24911258
28VDR_24763502_ChIP-Seq_THP-1_Human2.24143967
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.24025759
30GATA6_25053715_ChIP-Seq_YYC3_Human2.21561914
31SPI1_23127762_ChIP-Seq_K562_Human2.12849737
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.12764877
33KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.12764877
34KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.12764877
35STAT4_19710469_ChIP-ChIP_TH1__Mouse2.11446509
36VDR_24787735_ChIP-Seq_THP-1_Human2.08873313
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08550233
38* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.04923746
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.04858015
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.99426829
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.97869289
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90062067
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.83895335
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.82920688
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81199985
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.79282492
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.78672405
48FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.77231885
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.76381181
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74990887
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73047472
52SPI1_23547873_ChIP-Seq_NB4_Human1.72621084
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72129722
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68998082
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64132217
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62454966
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60329194
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58704610
59PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.56970292
60SCL_19346495_ChIP-Seq_HPC-7_Human1.55433062
61SOX2_20726797_ChIP-Seq_SW620_Human1.54961924
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49839321
63PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.47452996
64CHD1_26751641_Chip-Seq_LNCaP_Human1.47190132
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46272539
66* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.44920596
67AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.43504966
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.42143897
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39140241
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38458215
71P63_26484246_Chip-Seq_KERATINOCYTES_Human1.38353279
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37967645
73FOXO3_23340844_ChIP-Seq_DLD1_Human1.37874333
74TP63_17297297_ChIP-ChIP_HaCaT_Human1.37784228
75CDX2_20551321_ChIP-Seq_CACO-2_Human1.36770101
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36621435
77FOXA2_19822575_ChIP-Seq_HepG2_Human1.35850127
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.33715154
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.30396512
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29911030
81TFEB_21752829_ChIP-Seq_HELA_Human1.29502110
82* PU_27001747_Chip-Seq_BMDM_Mouse1.28566187
83STAT1_20625510_ChIP-Seq_HELA_Human1.27546093
84EGR1_19032775_ChIP-ChIP_M12_Human1.27222204
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26129905
86CLOCK_20551151_ChIP-Seq_293T_Human1.25208819
87FOXA1_25552417_ChIP-Seq_VCAP_Human1.24908594
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24788181
89GATA1_19941827_ChIP-Seq_MEL_Mouse1.24554782
90CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24030976
91GATA1_19941826_ChIP-Seq_K562_Human1.22773313
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22329545
93KDM2B_26808549_Chip-Seq_DND41_Human1.21640445
94RUNX1_27514584_Chip-Seq_MCF-7_Human1.19573530
95NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19487680
96ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19405583
97* CREB1_26743006_Chip-Seq_LNCaP_Human1.19341333
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18804685
99PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17214603
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17026864
101ESET_19884257_ChIP-Seq_ESCs_Mouse1.15616673
102PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15313949
103MAF_26560356_Chip-Seq_TH1_Human1.13523320
104ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12004633
105SA1_27219007_Chip-Seq_ERYTHROID_Human1.11600644
106GATA3_24758297_ChIP-Seq_MCF-7_Human1.11076840
107TCF7_22412390_ChIP-Seq_EML_Mouse1.10372351
108TP63_22573176_ChIP-Seq_HFKS_Human1.10072924
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09767590
110SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09302546
111BCOR_27268052_Chip-Seq_Bcells_Human1.09248582
112NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08748893
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08661667
114IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08328670
115* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08184987
116* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08103221
117BCL6_27268052_Chip-Seq_Bcells_Human1.07703562
118ATF3_27146783_Chip-Seq_COLON_Human1.07359472
119ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06883944
120ERG_20517297_ChIP-Seq_VCAP_Human1.06757154
121FOXH1_21741376_ChIP-Seq_ESCs_Human1.06505407
122FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.06056450
123PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05740201
124LXR_22292898_ChIP-Seq_THP-1_Human1.05684211
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03824836
126GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03616737
127KDM2B_26808549_Chip-Seq_K562_Human1.02929236
128BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02772379
129SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02644733
130PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02158117
131ELF1_20517297_ChIP-Seq_JURKAT_Human1.00549232
132PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00414484
133P68_20966046_ChIP-Seq_HELA_Human1.00105456
134IRF1_19129219_ChIP-ChIP_H3396_Human0.96688799
135TBX20_22328084_ChIP-Seq_HEART_Mouse0.95547175
136TBX20_22080862_ChIP-Seq_HEART_Mouse0.95547175
137VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95083398
138NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94163986
139SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94085415
140KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93883777
141MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93380706
142TRIM28_21343339_ChIP-Seq_HEK293_Human0.93026542
143RUNX_20019798_ChIP-Seq_JUKART_Human0.92761875
144GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92704213
145TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91715163
146FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.90978610
147FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90908150
148MAF_26560356_Chip-Seq_TH2_Human0.90787762
149NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90771590
150RACK7_27058665_Chip-Seq_MCF-7_Human0.90651232
151* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90402368
152NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89997933
153SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89883419
154CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89205676
155PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88524001
156UTX_26944678_Chip-Seq_JUKART_Human0.87737908
157ERA_21632823_ChIP-Seq_H3396_Human0.86450018
158ETS1_21867929_ChIP-Seq_TH2_Mouse0.85557649
159TAF2_19829295_ChIP-Seq_ESCs_Human0.85224793
160PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84965229
161P53_21459846_ChIP-Seq_SAOS-2_Human0.84464855
162KLF5_25053715_ChIP-Seq_YYC3_Human0.84098761
163NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.83250717
164OCT4_20526341_ChIP-Seq_ESCs_Human0.83001995
165GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82938306
166DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82588140
167ZNF274_21170338_ChIP-Seq_K562_Hela0.82520167
168KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82002018
169KLF4_19829295_ChIP-Seq_ESCs_Human0.80757115
170GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.80681219
171SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79709656
172FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.79359920
173TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77646762
174KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77571449
175CTCF_27219007_Chip-Seq_Bcells_Human0.74941309
176ELK4_26923725_Chip-Seq_MESODERM_Mouse0.74677115
177TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.74390744
178CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71046766
179* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.70573059

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract8.99999101
2MP0001666_abnormal_nutrient_absorption8.91916847
3MP0005220_abnormal_exocrine_pancreas6.56314122
4MP0005365_abnormal_bile_salt6.30972249
5MP0005084_abnormal_gallbladder_morpholo4.88633535
6MP0003868_abnormal_feces_composition4.84054037
7MP0003303_peritoneal_inflammation4.50782852
8MP0006082_CNS_inflammation3.79125987
9MP0009840_abnormal_foam_cell3.57409478
10MP0002148_abnormal_hypersensitivity_rea3.24305196
11MP0005085_abnormal_gallbladder_physiolo3.16688311
12MP0003436_decreased_susceptibility_to2.99794627
13MP0004510_myositis2.99724001
14MP0002138_abnormal_hepatobiliary_system2.86436506
15MP0002693_abnormal_pancreas_physiology2.80337174
16MP0003172_abnormal_lysosome_physiology2.76882706
17MP0003724_increased_susceptibility_to2.75487001
18MP0000343_altered_response_to2.64376566
19MP0009785_altered_susceptibility_to2.64132549
20MP0003075_altered_response_to2.54042943
21MP0003959_abnormal_lean_body2.50300605
22MP0002419_abnormal_innate_immunity2.47660279
23MP0000604_amyloidosis2.41924141
24MP0001664_abnormal_digestion2.41226081
25MP0005000_abnormal_immune_tolerance2.27301359
26MP0002139_abnormal_hepatobiliary_system2.25735360
27MP0005167_abnormal_blood-brain_barrier2.22574810
28MP0005387_immune_system_phenotype2.22258605
29MP0001790_abnormal_immune_system2.22258605
30MP0005671_abnormal_response_to2.21689930
31MP0005025_abnormal_response_to2.17137574
32MP0009764_decreased_sensitivity_to2.14610670
33MP0001835_abnormal_antigen_presentation2.13993145
34MP0001944_abnormal_pancreas_morphology2.04206843
35MP0010234_abnormal_vibrissa_follicle2.03355514
36MP0002254_reproductive_system_inflammat2.00233859
37MP0001533_abnormal_skeleton_physiology1.99844834
38MP0003705_abnormal_hypodermis_morpholog1.98691131
39MP0004264_abnormal_extraembryonic_tissu1.97695733
40MP0001853_heart_inflammation1.90152611
41MP0003191_abnormal_cellular_cholesterol1.89587315
42MP0003690_abnormal_glial_cell1.87944305
43MP0009278_abnormal_bone_marrow1.83804260
44MP0002452_abnormal_antigen_presenting1.82197434
45MP0002998_abnormal_bone_remodeling1.77446202
46MP0002723_abnormal_immune_serum1.76168510
47MP0003252_abnormal_bile_duct1.71532029
48MP0000685_abnormal_immune_system1.65250493
49MP0003453_abnormal_keratinocyte_physiol1.61925690
50MP0002928_abnormal_bile_duct1.55636278
51MP0003448_altered_tumor_morphology1.55496249
52MP0005448_abnormal_energy_balance1.54759546
53MP0008469_abnormal_protein_level1.53661591
54MP0001800_abnormal_humoral_immune1.53006084
55MP0005397_hematopoietic_system_phenotyp1.52973053
56MP0001545_abnormal_hematopoietic_system1.52973053
57MP0005310_abnormal_salivary_gland1.49829015
58MP0002405_respiratory_system_inflammati1.48779078
59MP0003300_gastrointestinal_ulcer1.47402102
60MP0001819_abnormal_immune_cell1.42799118
61MP0002420_abnormal_adaptive_immunity1.42600986
62MP0002277_abnormal_respiratory_mucosa1.42496879
63MP0004233_abnormal_muscle_weight1.40384417
64MP0003638_abnormal_response/metabolism_1.39346765
65MP0000858_altered_metastatic_potential1.38844637
66MP0010155_abnormal_intestine_physiology1.37412921
67MP0004947_skin_inflammation1.36259527
68MP0005166_decreased_susceptibility_to1.34470301
69MP0008004_abnormal_stomach_pH1.33004298
70MP0000920_abnormal_myelination1.32209690
71MP0002118_abnormal_lipid_homeostasis1.24718668
72MP0005464_abnormal_platelet_physiology1.24232867
73MP0005165_increased_susceptibility_to1.22242702
74MP0001542_abnormal_bone_strength1.18454561
75MP0005332_abnormal_amino_acid1.16332096
76MP0002837_dystrophic_cardiac_calcinosis1.15943706
77MP0008438_abnormal_cutaneous_collagen1.10152046
78MP0003828_pulmonary_edema1.08294841
79MP0009333_abnormal_splenocyte_physiolog1.06742483
80MP0002078_abnormal_glucose_homeostasis1.03566185
81MP0000613_abnormal_salivary_gland1.01519463
82MP0003045_fibrosis1.00881112
83MP0000470_abnormal_stomach_morphology0.98891340
84MP0001873_stomach_inflammation0.98483663
85MP0000003_abnormal_adipose_tissue0.97883841
86MP0008260_abnormal_autophagy0.97638624
87MP0003634_abnormal_glial_cell0.95139764
88MP0009780_abnormal_chondrocyte_physiolo0.94870697
89MP0005408_hypopigmentation0.94717207
90MP0002332_abnormal_exercise_endurance0.94437673
91MP0009384_cardiac_valve_regurgitation0.94353858
92MP0000716_abnormal_immune_system0.93798309
93MP0009643_abnormal_urine_homeostasis0.92921277
94MP0005451_abnormal_body_composition0.89933027
95MP0005390_skeleton_phenotype0.88968261
96MP0005164_abnormal_response_to0.88528120
97MP0005595_abnormal_vascular_smooth0.87315707
98MP0003279_aneurysm0.86345790
99MP0010307_abnormal_tumor_latency0.86017040
100MP0006054_spinal_hemorrhage0.82253208
101MP0002090_abnormal_vision0.80206618
102MP0002933_joint_inflammation0.79390868
103MP0009763_increased_sensitivity_to0.78640813
104MP0010386_abnormal_urinary_bladder0.76392952
105MP0005647_abnormal_sex_gland0.74799805
106MP0005023_abnormal_wound_healing0.74790746
107MP0003953_abnormal_hormone_level0.73973725
108MP0003195_calcinosis0.73402515
109MP0005535_abnormal_body_temperature0.72896568
110MP0000490_abnormal_crypts_of0.70291098
111MP0008961_abnormal_basal_metabolism0.70023248
112MP0003633_abnormal_nervous_system0.69544341
113MP0002429_abnormal_blood_cell0.68834008
114MP0004883_abnormal_blood_vessel0.68100176
115MP0000689_abnormal_spleen_morphology0.67095607
116MP0005058_abnormal_lysosome_morphology0.66362340
117MP0008874_decreased_physiological_sensi0.66113952
118MP0003091_abnormal_cell_migration0.66007827
119MP0003283_abnormal_digestive_organ0.64804592
120MP0002098_abnormal_vibrissa_morphology0.64654113
121MP0000249_abnormal_blood_vessel0.64005672
122MP0003183_abnormal_peptide_metabolism0.61809297
123MP0008789_abnormal_olfactory_epithelium0.61787911
124MP0003879_abnormal_hair_cell0.61323852
125MP0001663_abnormal_digestive_system0.61231687
126MP0002398_abnormal_bone_marrow0.60542745
127MP0001851_eye_inflammation0.59700296
128MP0005584_abnormal_enzyme/coenzyme_acti0.58636734
129MP0000465_gastrointestinal_hemorrhage0.57886330
130MP0001849_ear_inflammation0.57216268
131MP0004272_abnormal_basement_membrane0.57115897
132MP0004043_abnormal_pH_regulation0.55682258
133MP0002796_impaired_skin_barrier0.55145640
134MP0005452_abnormal_adipose_tissue0.54864490
135MP0009765_abnormal_xenobiotic_induced0.54309041
136MP0002060_abnormal_skin_morphology0.53771146
137MP0000598_abnormal_liver_morphology0.52390694
138MP0002089_abnormal_postnatal_growth/wei0.51330471
139MP0010329_abnormal_lipoprotein_level0.51125547
140MP0005381_digestive/alimentary_phenotyp0.50686711
141MP0003186_abnormal_redox_activity0.46446649
142MP0005187_abnormal_penis_morphology0.46326595
143MP0005375_adipose_tissue_phenotype0.46266055
144MP0000609_abnormal_liver_physiology0.46159973
145MP0000371_diluted_coat_color0.45651695
146MP0001731_abnormal_postnatal_growth0.44991157
147MP0001756_abnormal_urination0.44790785
148MP0001764_abnormal_homeostasis0.44772649
149MP0010678_abnormal_skin_adnexa0.44593508
150MP0002896_abnormal_bone_mineralization0.42244297
151MP0003806_abnormal_nucleotide_metabolis0.41689677
152MP0002009_preneoplasia0.41495629
153MP0001845_abnormal_inflammatory_respons0.41253187
154MP0005499_abnormal_olfactory_system0.40534395
155MP0005394_taste/olfaction_phenotype0.40534395
156MP0002876_abnormal_thyroid_physiology0.40259532
157MP0004185_abnormal_adipocyte_glucose0.39939970
158MP0000750_abnormal_muscle_regeneration0.39390915
159MP0000377_abnormal_hair_follicle0.38969817
160MP0001765_abnormal_ion_homeostasis0.38493779
161MP0005319_abnormal_enzyme/_coenzyme0.38416340
162MP0003795_abnormal_bone_structure0.35806666
163MP0006036_abnormal_mitochondrial_physio0.35118917
164MP0005636_abnormal_mineral_homeostasis0.34228017
165MP0003943_abnormal_hepatobiliary_system0.33707389
166MP0000367_abnormal_coat/_hair0.33225589
167MP0000566_synostosis0.32184151
168MP0005334_abnormal_fat_pad0.32106276
169MP0003656_abnormal_erythrocyte_physiolo0.31094744
170MP0005360_urolithiasis0.30464739
171MP0000647_abnormal_sebaceous_gland0.30322857
172MP0009642_abnormal_blood_homeostasis0.27669280
173MP0005275_abnormal_skin_tensile0.27313323
174MP0002168_other_aberrant_phenotype0.25999162
175MP0002877_abnormal_melanocyte_morpholog0.25649979
176MP0000537_abnormal_urethra_morphology0.24624734
177MP0002069_abnormal_eating/drinking_beha0.23092573
178MP0002295_abnormal_pulmonary_circulatio0.23048527
179MP0003329_amyloid_beta_deposits0.21145561

Predicted human phenotypes

RankGene SetZ-score
1Steatorrhea (HP:0002570)8.34639697
2Abnormality of glycolipid metabolism (HP:0010969)8.25594203
3Abnormality of liposaccharide metabolism (HP:0010968)8.25594203
4Abnormality of glycosphingolipid metabolism (HP:0004343)8.25594203
5Fat malabsorption (HP:0002630)6.98887017
6Gout (HP:0001997)6.46488819
7Systemic lupus erythematosus (HP:0002725)6.41531543
8Disinhibition (HP:0000734)5.95851807
9Increased cerebral lipofuscin (HP:0011813)5.66201033
10Exocrine pancreatic insufficiency (HP:0001738)5.63101444
11Short chin (HP:0000331)5.27086221
12Decreased subcutaneous fat (HP:0001002)5.26783521
13Mutism (HP:0002300)5.07433588
14Loss of speech (HP:0002371)4.93267539
15Abnormality of subcutaneous fat tissue (HP:0001001)4.82227502
16Type I diabetes mellitus (HP:0100651)4.79531368
17Increased neuronal autofluorescent lipopigment (HP:0002074)4.68807246
18Nuclear cataract (HP:0100018)4.65664236
19Abnormal pancreas size (HP:0012094)4.55205589
20Abnormality of the intrinsic pathway (HP:0010989)4.54872271
21Axonal loss (HP:0003447)4.54013196
22Glomerulonephritis (HP:0000099)4.36694542
23Abnormality of macrophages (HP:0004311)4.28486668
24Neurofibrillary tangles (HP:0002185)4.14247404
25Maternal diabetes (HP:0009800)4.10199265
26Hypoplasia of the pons (HP:0012110)4.08137400
27Tubulointerstitial fibrosis (HP:0005576)4.03764637
28Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.00347640
29Complement deficiency (HP:0004431)3.82106919
30Abnormality of the pons (HP:0007361)3.78761624
31Agnosia (HP:0010524)3.72889731
32Abnormality of the vasculature of the conjunctiva (HP:0008054)3.67354426
33Pancreatitis (HP:0001733)3.61442857
34Premature skin wrinkling (HP:0100678)3.61070954
35Ketoacidosis (HP:0001993)3.60426133
36Recurrent abscess formation (HP:0002722)3.56143436
37Inappropriate behavior (HP:0000719)3.49139432
38Recurrent bacterial skin infections (HP:0005406)3.48912124
39Ketosis (HP:0001946)3.46978560
40Tubulointerstitial nephritis (HP:0001970)3.44844568
41Autoimmune thrombocytopenia (HP:0001973)3.43695854
42Joint stiffness (HP:0001387)3.40519455
43Upper motor neuron abnormality (HP:0002127)3.37066791
44Cortical dysplasia (HP:0002539)3.33601991
45Abnormality of aromatic amino acid family metabolism (HP:0004338)3.33359518
46Abnormality of endocrine pancreas physiology (HP:0012093)3.31233671
47Abnormality of the pancreatic islet cells (HP:0006476)3.31233671
48Apathy (HP:0000741)3.24405447
49Hypoproteinemia (HP:0003075)3.23537681
50Hypoglycemic coma (HP:0001325)3.21503609
51Diminished motivation (HP:0000745)3.13523251
52Eczematoid dermatitis (HP:0000976)3.10171028
53Hypoglycemic seizures (HP:0002173)3.10111646
54Abnormality of complement system (HP:0005339)2.99856145
55Spontaneous hematomas (HP:0007420)2.97770758
56Facial shape deformation (HP:0011334)2.94975751
57Potter facies (HP:0002009)2.94975751
58Neuronal loss in central nervous system (HP:0002529)2.92068554
59Cerebral inclusion bodies (HP:0100314)2.92047264
60Personality changes (HP:0000751)2.89465886
61Hematochezia (HP:0002573)2.87427685
62Hyperuricemia (HP:0002149)2.85498769
63Increased purine levels (HP:0004368)2.85498769
64Recurrent gram-negative bacterial infections (HP:0005420)2.83663540
65Purpura (HP:0000979)2.83518930
66Carpal bone hypoplasia (HP:0001498)2.83083580
67Esophageal varix (HP:0002040)2.83003932
68Hyperinsulinemic hypoglycemia (HP:0000825)2.80551003
69Mediastinal lymphadenopathy (HP:0100721)2.78679363
70Abnormality of the common coagulation pathway (HP:0010990)2.78656823
71Hypoplasia of the uterus (HP:0000013)2.77012498
72Stomatitis (HP:0010280)2.75914951
73Amyloidosis (HP:0011034)2.75119484
74Long foot (HP:0001833)2.74980088
75Late onset (HP:0003584)2.70475109
76Orchitis (HP:0100796)2.67054530
77Progressive neurologic deterioration (HP:0002344)2.66859127
78Vacuolated lymphocytes (HP:0001922)2.65085214
79Hyperglycinemia (HP:0002154)2.63544164
80Dysostosis multiplex (HP:0000943)2.61741249
81Increased serum ferritin (HP:0003281)2.61723081
82Abnormality of sulfur amino acid metabolism (HP:0004339)2.61352166
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.61238290
84Abnormal tarsal ossification (HP:0008369)2.57666864
85Myositis (HP:0100614)2.54413278
86Dementia (HP:0000726)2.53720541
87Retinal atrophy (HP:0001105)2.53500333
88Abnormality of the renal cortex (HP:0011035)2.53446266
89Prolonged neonatal jaundice (HP:0006579)2.50098352
90Ventricular fibrillation (HP:0001663)2.45827515
91Hyperglycinuria (HP:0003108)2.44104701
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.43942785
93Abnormal protein N-linked glycosylation (HP:0012347)2.43942785
94Abnormal protein glycosylation (HP:0012346)2.43942785
95Abnormal glycosylation (HP:0012345)2.43942785
96Retrobulbar optic neuritis (HP:0100654)2.43662950
97Optic neuritis (HP:0100653)2.43662950
98Pectus carinatum (HP:0000768)2.42744689
99Pathologic fracture (HP:0002756)2.41289251
100Basal ganglia calcification (HP:0002135)2.40831100
101Metaphyseal irregularity (HP:0003025)2.40090237
102Conjugated hyperbilirubinemia (HP:0002908)2.39279373
103Tubulointerstitial abnormality (HP:0001969)2.36457715
104Congenital glaucoma (HP:0001087)2.36082850
105Right ventricular cardiomyopathy (HP:0011663)2.34587517
106Hypoplasia of the odontoid process (HP:0003311)2.31952790
107Fatigue (HP:0012378)2.31666036
108Conjunctival telangiectasia (HP:0000524)2.31260382
109Hepatosplenomegaly (HP:0001433)2.28082492
110Prenatal maternal abnormality (HP:0002686)2.25580191
111Supranuclear gaze palsy (HP:0000605)2.25228125
112Renal salt wasting (HP:0000127)2.24380364
113Optic nerve hypoplasia (HP:0000609)2.23897927
114Petechiae (HP:0000967)2.23258094
115Barrel-shaped chest (HP:0001552)2.23020600
116Nephritis (HP:0000123)2.22722653
117Abnormality of serine family amino acid metabolism (HP:0010894)2.20678987
118Abnormality of glycine metabolism (HP:0010895)2.20678987
119Asymmetric septal hypertrophy (HP:0001670)2.20514320
120Symptomatic seizures (HP:0011145)2.19423689
121Progressive muscle weakness (HP:0003323)2.17919685
122Hyperglycemia (HP:0003074)2.16297627
123Rectal prolapse (HP:0002035)2.15618571
124Peripheral demyelination (HP:0011096)2.15252163
125Chronic obstructive pulmonary disease (HP:0006510)2.14120086
126Obstructive lung disease (HP:0006536)2.14120086
127Vertebral compression fractures (HP:0002953)2.12701331
128Mucopolysacchariduria (HP:0008155)2.08517793
129Urinary glycosaminoglycan excretion (HP:0003541)2.08517793
130Interstitial pulmonary disease (HP:0006530)2.07351076
131Abnormality of purine metabolism (HP:0004352)2.05945509
132Abnormality of iron homeostasis (HP:0011031)2.05446081
133Aplasia/hypoplasia of the uterus (HP:0008684)2.03875438
134Polyneuropathy (HP:0001271)2.03739548
135Acute hepatic failure (HP:0006554)2.03612554
136Small epiphyses (HP:0010585)2.03422823
137Memory impairment (HP:0002354)2.02683972
138Neonatal death (HP:0003811)2.02632873
139Thoracic kyphosis (HP:0002942)1.99105083
140Ankyloglossia (HP:0010296)1.98705530
141Zonular cataract (HP:0010920)1.98389409
142Large for gestational age (HP:0001520)1.98369354
143Abnormal foot bone ossification (HP:0010675)1.97891298
144Beaking of vertebral bodies (HP:0004568)1.97709920
145Coxa valga (HP:0002673)1.97207030
146Type II lissencephaly (HP:0007260)1.96122122
147Tubular atrophy (HP:0000092)1.95634134
148Bone pain (HP:0002653)1.93817865
149Abnormality of the nasal mucosa (HP:0000433)1.93667487
150Pulmonary infiltrates (HP:0002113)1.93483187
151Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92906813
152Prolonged QT interval (HP:0001657)1.92741567
153Gingivitis (HP:0000230)1.91951157
154Cardiomegaly (HP:0001640)1.91894363
155Severe short stature (HP:0003510)1.88858196
156Cortical visual impairment (HP:0100704)1.87376052
157Malnutrition (HP:0004395)1.85656640
158Myocardial infarction (HP:0001658)1.85404404
159Congenital sensorineural hearing impairment (HP:0008527)1.83913657
160Abnormality of the basal ganglia (HP:0002134)1.83194564
161Abnormality of the odontoid process (HP:0003310)1.82416120
162Abnormality of polysaccharide metabolism (HP:0011012)1.82103270
163Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82103270
164Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82103270
165Reduced antithrombin III activity (HP:0001976)1.79975775
166Increased CSF protein (HP:0002922)1.79242442
167Abnormality of homocysteine metabolism (HP:0010919)1.78969248
168Homocystinuria (HP:0002156)1.78969248
169Unilateral renal agenesis (HP:0000122)1.78676265
170Nausea (HP:0002018)1.78352365
171Epiphyseal dysplasia (HP:0002656)1.77187379
172Urinary incontinence (HP:0000020)1.76619331
173Global brain atrophy (HP:0002283)1.76600445
174Progressive visual loss (HP:0000529)1.75928687
175Glomerulosclerosis (HP:0000096)1.74837353
176Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.73311172
177Bone cyst (HP:0012062)1.73068116
178Abnormality of methionine metabolism (HP:0010901)1.73053459
179Multiple enchondromatosis (HP:0005701)1.73029453
180Recurrent skin infections (HP:0001581)1.72882182
181Limb hypertonia (HP:0002509)1.72619124
182Mesangial abnormality (HP:0001966)1.70999560
183Abnormality of the periventricular white matter (HP:0002518)1.70917491
184Acrocyanosis (HP:0001063)1.70881732
185Tetraparesis (HP:0002273)1.69891863
186Hemoptysis (HP:0002105)1.69334437
187J-shaped sella turcica (HP:0002680)1.68566418
188Abnormality of lateral ventricle (HP:0030047)1.67252879
189Keratoconjunctivitis sicca (HP:0001097)1.63805242
190Mucosal telangiectasiae (HP:0100579)1.62303033
191Abnormality of transition element cation homeostasis (HP:0011030)1.62200447

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK8.78576668
2ERN15.63424730
3EIF2AK34.13781783
4MAP2K23.70342719
5FRK3.45082570
6INSRR3.40563332
7GRK73.03250913
8MAP3K112.85626419
9TRIB32.85241851
10TAOK22.80623775
11BLK2.78128866
12MAP3K142.71015228
13TAOK32.51075259
14TBK12.49640633
15PKN22.37248964
16TAOK12.23435052
17MATK2.18129318
18ACVR1B2.11765122
19MAPKAPK32.10629495
20PIM22.08939420
21FGR2.02215239
22MAPK151.89055889
23IKBKB1.84517200
24RIPK41.83931964
25ABL21.83283073
26ZAP701.79900090
27IRAK31.76087086
28CSK1.71981815
29SCYL21.70613960
30MAP2K31.64691914
31TYK21.64429124
32LATS11.56763660
33MOS1.53060708
34TESK11.49519252
35MAP2K11.47235421
36MAP4K11.45857013
37WNK41.42054753
38PRPF4B1.40307149
39PAK21.35045734
40MAP3K21.33467049
41PTK61.31991896
42CSF1R1.25116993
43LMTK21.25055683
44TGFBR11.23928346
45IKBKE1.22298804
46PIK3CG1.21568466
47SIK11.20206824
48NME11.18356794
49ADRBK21.17962397
50PDGFRB1.12651217
51RPS6KB21.11864851
52TESK21.08814641
53EPHB21.08047132
54DYRK1A1.06719535
55EEF2K1.06287303
56PIK3CA1.05792729
57CHUK1.00629024
58JAK30.99226057
59STK390.98961476
60FLT30.94783455
61FES0.94087477
62MAP3K130.92086034
63LYN0.92079423
64NME20.91894455
65TYRO30.85217070
66SYK0.84806819
67SIK30.84578927
68TXK0.84475543
69MAP3K50.82869347
70PDK20.79819318
71IRAK20.78054451
72CAMKK10.75958281
73MARK30.72597970
74DYRK1B0.72427534
75MTOR0.70713539
76ARAF0.69533994
77FER0.68999899
78PAK40.66895839
79BMPR20.64489060
80CDK60.62262523
81DAPK20.61962914
82MAP2K60.61822464
83RET0.61232793
84CAMKK20.61192788
85LRRK20.60521185
86PRKCI0.59526651
87LCK0.58603862
88PRKCH0.57311167
89ICK0.56748392
90DAPK30.55273454
91MAP3K10.54131486
92RIPK10.54042954
93PDPK10.50796406
94MAPK40.50763317
95PDGFRA0.50128094
96LIMK10.50003762
97RPS6KB10.49270894
98MET0.49239166
99TNK20.47874089
100HIPK20.47489932
101PRKD30.47170870
102IRAK40.46640870
103PTK20.46002182
104DDR20.45901821
105PKN10.45825643
106MST1R0.45403708
107HCK0.45358334
108BTK0.45177694
109PRKCZ0.44967359
110KIT0.44888656
111NEK60.44825985
112MAP3K30.44110580
113LATS20.42467664
114NTRK10.42425007
115NEK90.41543115
116RPS6KC10.41244395
117RPS6KL10.41244395
118EPHB10.40328220
119IRAK10.39701261
120JAK20.39304100
121NUAK10.37779748
122PIM10.36856823
123PASK0.35637557
124PDK10.35615521
125PRKD10.35073009
126FGFR40.34580550
127CAMK1D0.34127398
128MAPK120.33972426
129BMX0.33663247
130AKT30.33501104
131MAPK70.33430063
132SIK20.32534655
133PRKG20.32266316
134EPHA30.32176406
135STK100.32168088
136MAP3K70.32160365
137KSR20.31828877
138FGFR30.31639848
139DYRK30.31273898
140MARK20.31047472
141RPS6KA20.30777594
142RPS6KA60.30512174
143MAPK30.28538346
144TIE10.25494294
145IGF1R0.24286067
146INSR0.24092827
147PRKCD0.24020538
148PRKACB0.22322819
149ABL10.21854123
150RPS6KA10.20522671
151BRAF0.20380013
152TGFBR20.19988849
153PINK10.19034543
154CSNK1A1L0.18612175
155PRKAA10.17177279
156MAPK10.16932676
157WNK10.16351094
158FGFR20.16156702
159CDC42BPA0.15440701
160GSK3A0.15345493
161PRKD20.15298649
162EGFR0.14527420
163JAK10.14131422
164ILK0.13735881
165CSNK1A10.11173927
166ERBB20.11125668
167CSNK1G20.10475490
168CSNK1E0.09919477
169PRKCE0.09630438
170CAMK1G0.09584428

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049728.27277688
2Fat digestion and absorption_Homo sapiens_hsa049755.84308370
3Protein digestion and absorption_Homo sapiens_hsa049745.66513858
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.83485058
5Protein export_Homo sapiens_hsa030603.60740589
6Staphylococcus aureus infection_Homo sapiens_hsa051503.40986153
7Rheumatoid arthritis_Homo sapiens_hsa053232.95824644
8Glycerolipid metabolism_Homo sapiens_hsa005612.88024873
9Osteoclast differentiation_Homo sapiens_hsa043802.71930447
10Asthma_Homo sapiens_hsa053102.67516891
11Folate biosynthesis_Homo sapiens_hsa007902.66380316
12Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.54174469
13Allograft rejection_Homo sapiens_hsa053302.39863094
14Toll-like receptor signaling pathway_Homo sapiens_hsa046202.39749031
15Leishmaniasis_Homo sapiens_hsa051402.33199223
16Cyanoamino acid metabolism_Homo sapiens_hsa004602.31688960
17Pertussis_Homo sapiens_hsa051332.24446228
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.09630606
19Tuberculosis_Homo sapiens_hsa051522.06570469
20Malaria_Homo sapiens_hsa051442.04290769
21NF-kappa B signaling pathway_Homo sapiens_hsa040642.02581764
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00058305
23Graft-versus-host disease_Homo sapiens_hsa053321.96096180
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.95949735
25Vitamin digestion and absorption_Homo sapiens_hsa049771.92760883
26Autoimmune thyroid disease_Homo sapiens_hsa053201.92744749
27Renin-angiotensin system_Homo sapiens_hsa046141.77868927
28Salmonella infection_Homo sapiens_hsa051321.77226428
29Prion diseases_Homo sapiens_hsa050201.76312163
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75653421
31Phagosome_Homo sapiens_hsa041451.74536875
32TNF signaling pathway_Homo sapiens_hsa046681.73571534
33Steroid biosynthesis_Homo sapiens_hsa001001.68651614
34Antigen processing and presentation_Homo sapiens_hsa046121.65932282
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.65660161
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63218282
37Propanoate metabolism_Homo sapiens_hsa006401.58435399
38Collecting duct acid secretion_Homo sapiens_hsa049661.46646178
39Complement and coagulation cascades_Homo sapiens_hsa046101.42219793
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37624147
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.23801408
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18064902
43Hematopoietic cell lineage_Homo sapiens_hsa046401.17827072
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15520301
45African trypanosomiasis_Homo sapiens_hsa051431.14091759
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13485654
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12643677
48Viral myocarditis_Homo sapiens_hsa054161.12579951
49Sphingolipid metabolism_Homo sapiens_hsa006001.08765776
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08278166
51N-Glycan biosynthesis_Homo sapiens_hsa005101.07304806
52Linoleic acid metabolism_Homo sapiens_hsa005911.07103414
53Other glycan degradation_Homo sapiens_hsa005111.02262551
54Arginine and proline metabolism_Homo sapiens_hsa003301.00176088
55Sulfur metabolism_Homo sapiens_hsa009201.00150863
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98195899
57B cell receptor signaling pathway_Homo sapiens_hsa046620.93535810
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91147903
59Mineral absorption_Homo sapiens_hsa049780.90796790
60Starch and sucrose metabolism_Homo sapiens_hsa005000.89802825
61Insulin secretion_Homo sapiens_hsa049110.88277146
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87978142
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87931800
64Shigellosis_Homo sapiens_hsa051310.86568943
65Amoebiasis_Homo sapiens_hsa051460.84186560
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84164430
67Vibrio cholerae infection_Homo sapiens_hsa051100.82209888
68Herpes simplex infection_Homo sapiens_hsa051680.80479248
69Chemokine signaling pathway_Homo sapiens_hsa040620.80191584
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77664168
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77427905
72Hepatitis C_Homo sapiens_hsa051600.75868290
73Apoptosis_Homo sapiens_hsa042100.75800334
74Selenocompound metabolism_Homo sapiens_hsa004500.74097188
75Influenza A_Homo sapiens_hsa051640.73585762
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70041377
77Biosynthesis of amino acids_Homo sapiens_hsa012300.69679638
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.67468393
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66951995
80Synaptic vesicle cycle_Homo sapiens_hsa047210.66071750
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.64764190
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64480102
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.63759561
84Notch signaling pathway_Homo sapiens_hsa043300.63448446
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61548896
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61381875
87Measles_Homo sapiens_hsa051620.60592516
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60558614
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60413921
90PPAR signaling pathway_Homo sapiens_hsa033200.59592113
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.58902119
92Acute myeloid leukemia_Homo sapiens_hsa052210.58054085
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55885735
94Hepatitis B_Homo sapiens_hsa051610.55363944
95Galactose metabolism_Homo sapiens_hsa000520.54775073
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52157347
97beta-Alanine metabolism_Homo sapiens_hsa004100.50171307
98Epstein-Barr virus infection_Homo sapiens_hsa051690.49706491
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49568482
100Fatty acid degradation_Homo sapiens_hsa000710.48073688
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48039032
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47163180
103T cell receptor signaling pathway_Homo sapiens_hsa046600.46606710
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45235609
105Endocytosis_Homo sapiens_hsa041440.44265550
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43347203
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.42557505
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42282257
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41981683
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.41009948
111One carbon pool by folate_Homo sapiens_hsa006700.40953993
112Prolactin signaling pathway_Homo sapiens_hsa049170.39497437
113Arachidonic acid metabolism_Homo sapiens_hsa005900.38696389
114Lysosome_Homo sapiens_hsa041420.38477177
115Primary immunodeficiency_Homo sapiens_hsa053400.36176321
116Pyruvate metabolism_Homo sapiens_hsa006200.35170303
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35140736
118Tryptophan metabolism_Homo sapiens_hsa003800.34984731
119Endometrial cancer_Homo sapiens_hsa052130.34943895
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32657989
121Legionellosis_Homo sapiens_hsa051340.32499749
122Nitrogen metabolism_Homo sapiens_hsa009100.31821176
123Systemic lupus erythematosus_Homo sapiens_hsa053220.30963831
124Arginine biosynthesis_Homo sapiens_hsa002200.28756678
125Regulation of autophagy_Homo sapiens_hsa041400.28335533
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.28079750
127Prostate cancer_Homo sapiens_hsa052150.27158077
128Fructose and mannose metabolism_Homo sapiens_hsa000510.27137210
129HIF-1 signaling pathway_Homo sapiens_hsa040660.25992979
130Ether lipid metabolism_Homo sapiens_hsa005650.24235794
131HTLV-I infection_Homo sapiens_hsa051660.23948249
132Metabolic pathways_Homo sapiens_hsa011000.23869394
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22686319
134Glutathione metabolism_Homo sapiens_hsa004800.21707635
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21355470
136Insulin resistance_Homo sapiens_hsa049310.20570902
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19550591
138Thyroid hormone synthesis_Homo sapiens_hsa049180.18898050
139Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18847617
140VEGF signaling pathway_Homo sapiens_hsa043700.17598121
141Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17538727
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.17499977
143Sulfur relay system_Homo sapiens_hsa041220.17113757
144mTOR signaling pathway_Homo sapiens_hsa041500.17069783
145Platelet activation_Homo sapiens_hsa046110.16199889
146SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13743567
147Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.13638567
148Calcium signaling pathway_Homo sapiens_hsa040200.12683695
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12221521
150GnRH signaling pathway_Homo sapiens_hsa049120.11719492
151Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11569285
152Alzheimers disease_Homo sapiens_hsa050100.11390508
153Cocaine addiction_Homo sapiens_hsa050300.09936521
154Bladder cancer_Homo sapiens_hsa052190.09912395
155Toxoplasmosis_Homo sapiens_hsa051450.09836024
156Glycosaminoglycan degradation_Homo sapiens_hsa005310.09612224
157Carbon metabolism_Homo sapiens_hsa012000.09482608
158Bile secretion_Homo sapiens_hsa049760.09273406
159Fatty acid metabolism_Homo sapiens_hsa012120.08713500
160Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.08184828
161MAPK signaling pathway_Homo sapiens_hsa040100.07793610
162Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07397930
163Glycerophospholipid metabolism_Homo sapiens_hsa005640.06588964
164Type I diabetes mellitus_Homo sapiens_hsa049400.06152995
165Type II diabetes mellitus_Homo sapiens_hsa049300.05980820
166Gastric acid secretion_Homo sapiens_hsa049710.05404977
167Estrogen signaling pathway_Homo sapiens_hsa049150.04197911
168Tight junction_Homo sapiens_hsa045300.03535692
169Aldosterone synthesis and secretion_Homo sapiens_hsa049250.03159025
170Pancreatic cancer_Homo sapiens_hsa052120.02980020
171Histidine metabolism_Homo sapiens_hsa003400.02960241
172AMPK signaling pathway_Homo sapiens_hsa041520.02671224
173Non-small cell lung cancer_Homo sapiens_hsa052230.01429266
174Inositol phosphate metabolism_Homo sapiens_hsa005620.01399576

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