RNASE10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of chemical stimulus involved in sensory perception of smell (GO:0050911)9.74951013
2indole-containing compound catabolic process (GO:0042436)9.17788526
3indolalkylamine catabolic process (GO:0046218)9.17788526
4tryptophan catabolic process (GO:0006569)9.17788526
5* seminiferous tubule development (GO:0072520)9.00746236
6positive regulation of protein sumoylation (GO:0033235)8.79360978
7positive regulation of type 2 immune response (GO:0002830)8.49058224
8negative regulation of T-helper cell differentiation (GO:0045623)8.28370225
9negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)8.28370225
10negative regulation of interleukin-10 production (GO:0032693)8.15369649
11tryptophan metabolic process (GO:0006568)7.94466576
12protein K11-linked deubiquitination (GO:0035871)7.84754287
13regulation of T-helper 2 cell differentiation (GO:0045628)7.30954790
14regulation of T-helper 1 cell differentiation (GO:0045625)7.06847804
15negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)6.76402535
16negative regulation of type 2 immune response (GO:0002829)6.63687369
17* single fertilization (GO:0007338)6.39068791
18detection of chemical stimulus involved in sensory perception (GO:0050907)6.30683645
19negative regulation of interleukin-8 production (GO:0032717)6.26514720
20enteric nervous system development (GO:0048484)6.00312504
21cellular biogenic amine catabolic process (GO:0042402)5.93454701
22amine catabolic process (GO:0009310)5.93454701
23cAMP biosynthetic process (GO:0006171)5.92690247
24aromatic amino acid family catabolic process (GO:0009074)5.86271323
25indolalkylamine metabolic process (GO:0006586)5.78506561
26activation of protein kinase A activity (GO:0034199)5.68262322
27negative regulation of alpha-beta T cell differentiation (GO:0046639)5.58867979
28phosphatidylinositol acyl-chain remodeling (GO:0036149)5.40587533
29cellular response to ATP (GO:0071318)5.39965478
30synaptic transmission, dopaminergic (GO:0001963)5.38601435
31positive regulation of RNA splicing (GO:0033120)5.34215956
32phosphatidylserine acyl-chain remodeling (GO:0036150)5.32772946
33phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.24003465
34regulation of protein sumoylation (GO:0033233)5.08705183
35benzene-containing compound metabolic process (GO:0042537)4.84918032
36positive regulation of T-helper 1 type immune response (GO:0002827)4.83903788
37negative regulation of T cell apoptotic process (GO:0070233)4.71115410
38digestion (GO:0007586)4.64468423
39negative regulation of endopeptidase activity (GO:0010951)4.63290771
40arachidonic acid secretion (GO:0050482)4.56884644
41icosanoid secretion (GO:0032309)4.56884644
42* fertilization (GO:0009566)4.52128982
43detection of chemical stimulus (GO:0009593)4.47516737
44regulation of type 2 immune response (GO:0002828)4.46105774
45N-acetylneuraminate metabolic process (GO:0006054)4.45632310
46positive regulation of T-helper cell differentiation (GO:0045624)4.44720431
47negative regulation of peptidase activity (GO:0010466)4.42972821
48sialylation (GO:0097503)4.42233134
49detection of light stimulus involved in visual perception (GO:0050908)4.33780016
50detection of light stimulus involved in sensory perception (GO:0050962)4.33780016
51aromatic amino acid family metabolic process (GO:0009072)4.29363669
52endothelial cell differentiation (GO:0045446)4.26066868
53positive regulation of mitochondrial fission (GO:0090141)4.24074071
54gonadal mesoderm development (GO:0007506)4.22927647
55negative regulation of protein autophosphorylation (GO:0031953)4.22642975
56defense response to bacterium (GO:0042742)4.20461649
57regulation of cAMP-mediated signaling (GO:0043949)4.14312979
58negative regulation of alpha-beta T cell activation (GO:0046636)4.06251763
59phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.01060278
60dendritic spine morphogenesis (GO:0060997)4.01041617
61positive thymic T cell selection (GO:0045059)3.99144734
62transepithelial transport (GO:0070633)3.98892500
63cilium or flagellum-dependent cell motility (GO:0001539)3.98298731
64indole-containing compound metabolic process (GO:0042430)3.90795288
65thymic T cell selection (GO:0045061)3.88512498
66hepatocyte apoptotic process (GO:0097284)3.88297319
67negative regulation of glycogen biosynthetic process (GO:0045719)3.86371162
68righting reflex (GO:0060013)3.85595083
69negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.79046930
70negative regulation of actin filament bundle assembly (GO:0032232)3.70857982
71male meiosis (GO:0007140)3.69671590
72regulation of T-helper 1 type immune response (GO:0002825)3.68932755
73GDP-mannose metabolic process (GO:0019673)3.67253007
74cytokinetic process (GO:0032506)3.60049452
75response to bacterium (GO:0009617)3.59870992
76positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.55927867
77reverse cholesterol transport (GO:0043691)3.54774209
78columnar/cuboidal epithelial cell development (GO:0002066)3.54322845
79icosanoid transport (GO:0071715)3.51270586
80fatty acid derivative transport (GO:1901571)3.51270586
81positive regulation of interleukin-12 production (GO:0032735)3.50387695
82regulation of clathrin-mediated endocytosis (GO:2000369)3.47934000
83regulation of T-helper cell differentiation (GO:0045622)3.44439119
84negative regulation of glycogen metabolic process (GO:0070874)3.40972742
85leukotriene biosynthetic process (GO:0019370)3.39544027
86phosphatidylcholine acyl-chain remodeling (GO:0036151)3.36243435
87piRNA metabolic process (GO:0034587)3.35878350
88nephron tubule morphogenesis (GO:0072078)3.32079485
89nephron epithelium morphogenesis (GO:0072088)3.32079485
90sulfur amino acid catabolic process (GO:0000098)3.30678493
91phospholipid homeostasis (GO:0055091)3.27632749
92hyaluronan catabolic process (GO:0030214)3.27150181
93monoamine transport (GO:0015844)3.22288286
94regulation of mitochondrial fission (GO:0090140)3.21957816
95positive regulation of cellular amide metabolic process (GO:0034250)3.17838024
96fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.17187914
97positive regulation of histone deacetylation (GO:0031065)3.16347611
98negative regulation of T cell differentiation (GO:0045581)3.15373429
99motile cilium assembly (GO:0044458)3.15289433
100regulation of macrophage activation (GO:0043030)3.14757045
101positive T cell selection (GO:0043368)3.13763593
102regulation of activated T cell proliferation (GO:0046006)3.12785979
103low-density lipoprotein particle clearance (GO:0034383)3.11316086
104neuronal ion channel clustering (GO:0045161)3.11014016
105O-glycan processing (GO:0016266)3.10879891
106response to dietary excess (GO:0002021)3.09069792
107negative regulation of interleukin-6 production (GO:0032715)3.06691290
108ATP hydrolysis coupled proton transport (GO:0015991)3.05627031
109energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.05627031
110positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.04464777
111positive regulation of protein kinase C signaling (GO:0090037)3.01665537
112negative regulation of proteolysis (GO:0045861)3.00908281
113DNA methylation involved in gamete generation (GO:0043046)3.00751287
114positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.00113669
115regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.99328652
116T cell selection (GO:0045058)2.97296717
117phosphatidylglycerol metabolic process (GO:0046471)2.96449858
118glutathione biosynthetic process (GO:0006750)2.93051730
119rRNA methylation (GO:0031167)2.92639419
120regulation of retinoic acid receptor signaling pathway (GO:0048385)2.92233960
121retina layer formation (GO:0010842)2.91246734
122negative regulation of protein processing (GO:0010955)2.89383765
123negative regulation of protein maturation (GO:1903318)2.89383765
124phosphatidylserine metabolic process (GO:0006658)2.89185787
125negative regulation of lymphocyte apoptotic process (GO:0070229)2.88232183
126regulation of oxidative stress-induced neuron death (GO:1903203)2.86875943
127DNA deamination (GO:0045006)2.86791086
128negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.86461952
129cAMP metabolic process (GO:0046058)2.84987014
130neural tube formation (GO:0001841)2.84976953
131mitochondrial fusion (GO:0008053)2.84101029
132chemosensory behavior (GO:0007635)2.81389631
133regulation of lipoprotein metabolic process (GO:0050746)2.80431172
134glial cell proliferation (GO:0014009)2.79224658
135exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79165195
136regulation of cholesterol storage (GO:0010885)2.77958438
137adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)2.77906330
138negative regulation of protein oligomerization (GO:0032460)2.76402894
139histone arginine methylation (GO:0034969)2.76359413
140positive regulation of protein deacetylation (GO:0090312)2.72803042
141L-serine transport (GO:0015825)2.72649793
142phosphatidylglycerol biosynthetic process (GO:0006655)2.71235914
143positive regulation of protein targeting to membrane (GO:0090314)2.71095323
144positive regulation of cAMP-mediated signaling (GO:0043950)2.70074551
145drug transmembrane transport (GO:0006855)2.69267823
146signal peptide processing (GO:0006465)2.69042607
147positive regulation of protein homooligomerization (GO:0032464)2.68267957
148behavioral response to nicotine (GO:0035095)2.66251931
149nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.65936371
150cyclic nucleotide biosynthetic process (GO:0009190)2.65750273
151alpha-linolenic acid metabolic process (GO:0036109)2.65520867
152vesicle targeting (GO:0006903)2.65471689
153negative regulation of hydrolase activity (GO:0051346)2.63076723
154regulation of endopeptidase activity (GO:0052548)2.61721265
155serine transport (GO:0032329)2.61688827
156regulation of T cell apoptotic process (GO:0070232)2.56289981
157cellular response to epidermal growth factor stimulus (GO:0071364)2.55500764
158regulation of interleukin-12 production (GO:0032655)2.55173664
159regulation of interleukin-10 production (GO:0032653)2.54876995
160valine metabolic process (GO:0006573)2.50072022
161regulation of peptidase activity (GO:0052547)2.49671175
162COPI coating of Golgi vesicle (GO:0048205)2.48735310
163Golgi transport vesicle coating (GO:0048200)2.48735310
164phagocytosis, recognition (GO:0006910)2.47409449
165complement activation, alternative pathway (GO:0006957)2.45303973
166regulation of beta-amyloid formation (GO:1902003)2.45260810
167high-density lipoprotein particle remodeling (GO:0034375)2.41711405
168hormone catabolic process (GO:0042447)2.40940612
169positive regulation of cellular response to oxidative stress (GO:1900409)2.40282978
170positive regulation of response to oxidative stress (GO:1902884)2.40282978
171negative regulation of T cell proliferation (GO:0042130)2.34409893
172pyrimidine ribonucleoside catabolic process (GO:0046133)2.33774725
173negative regulation of receptor-mediated endocytosis (GO:0048261)2.33616777
174cellular anion homeostasis (GO:0030002)2.33426058
175positive regulation of cholesterol transport (GO:0032376)2.31542610
176positive regulation of sterol transport (GO:0032373)2.31542610
177lipid catabolic process (GO:0016042)2.29802426
178negative regulation of tumor necrosis factor production (GO:0032720)2.29196774
179peptide catabolic process (GO:0043171)2.24703052
180negative regulation of glucose import (GO:0046325)2.24151175
181lipid storage (GO:0019915)2.21039775
182response to misfolded protein (GO:0051788)2.20748104
183defense response to other organism (GO:0098542)2.20123677
184negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.20029193
185microglial cell activation (GO:0001774)2.19568372
186regulation of amyloid precursor protein catabolic process (GO:1902991)2.18589778
187protein O-linked glycosylation (GO:0006493)2.18560440
188negative regulation of leukocyte apoptotic process (GO:2000107)2.17684168
189neutral amino acid transport (GO:0015804)2.17146920
190response to vitamin A (GO:0033189)2.14671567
191regulation of T cell tolerance induction (GO:0002664)16.3570075
192production of molecular mediator involved in inflammatory response (GO:0002532)16.3477411
193positive regulation of tolerance induction (GO:0002645)14.1453367
194regulation of tolerance induction (GO:0002643)12.4492892
195sperm capacitation (GO:0048240)12.1761918
196kynurenine metabolic process (GO:0070189)11.1031415
197tooth mineralization (GO:0034505)10.4010835
198regulation of chronic inflammatory response (GO:0002676)10.3311177

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.09632719
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.79910750
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human4.34560576
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.29281153
5IKZF1_21737484_ChIP-ChIP_HCT116_Human3.79875994
6FLI1_27457419_Chip-Seq_LIVER_Mouse3.29768349
7VDR_22108803_ChIP-Seq_LS180_Human3.13403511
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.03775489
9YY1_22570637_ChIP-Seq_MALME-3M_Human2.89301437
10AR_21572438_ChIP-Seq_LNCaP_Human2.85949739
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.63785155
12CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.62874255
13ZNF263_19887448_ChIP-Seq_K562_Human2.53930339
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.53872748
15LXR_22292898_ChIP-Seq_THP-1_Human2.36343244
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.27536681
17IGF1R_20145208_ChIP-Seq_DFB_Human2.26485532
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.26140571
19PHF8_20622854_ChIP-Seq_HELA_Human2.08987226
20* E2F1_20622854_ChIP-Seq_HELA_Human2.07413501
21CTCF_27219007_Chip-Seq_Bcells_Human2.07279983
22CLOCK_20551151_ChIP-Seq_293T_Human2.06787121
23PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse2.00740639
24* BCL6_27268052_Chip-Seq_Bcells_Human1.97574199
25* P68_20966046_ChIP-Seq_HELA_Human1.96996937
26VDR_21846776_ChIP-Seq_THP-1_Human1.96145438
27DROSHA_22980978_ChIP-Seq_HELA_Human1.90270432
28SMAD1_18555785_Chip-Seq_ESCs_Mouse1.90231329
29GATA1_19941826_ChIP-Seq_K562_Human1.86659469
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.86344273
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.86325501
32GATA3_21867929_ChIP-Seq_TH1_Mouse1.82127453
33CTCF_27219007_Chip-Seq_ERYTHROID_Human1.81768107
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.81429700
35SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.78345558
36SA1_27219007_Chip-Seq_Bcells_Human1.76912370
37* LXR_22158963_ChIP-Seq_LIVER_Mouse1.75796914
38VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.75254162
39* ERA_21632823_ChIP-Seq_H3396_Human1.74664717
40BCOR_27268052_Chip-Seq_Bcells_Human1.74068451
41MAF_26560356_Chip-Seq_TH2_Human1.72052835
42ZNF274_21170338_ChIP-Seq_K562_Hela1.70569052
43RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.69170658
44ESRRB_18555785_Chip-Seq_ESCs_Mouse1.66611199
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65904307
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.65813371
47* RXR_22158963_ChIP-Seq_LIVER_Mouse1.65180914
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64802277
49FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.62091188
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61483513
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61350268
52GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.59039688
53EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.58410178
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.55939526
55SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.55838310
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.55413692
57NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.53535186
58NANOG_20526341_ChIP-Seq_ESCs_Human1.50397095
59FLI1_21867929_ChIP-Seq_CD8_Mouse1.50339762
60VDR_24787735_ChIP-Seq_THP-1_Human1.49968119
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.49000582
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48451796
63* RAC3_21632823_ChIP-Seq_H3396_Human1.47660013
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47489043
65CTCF_21964334_ChIP-Seq_BJAB-B_Human1.47460016
66WT1_19549856_ChIP-ChIP_CCG9911_Human1.47230144
67CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45737953
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45641316
69SMAD4_21741376_ChIP-Seq_HESCs_Human1.44731175
70CTCF_18555785_Chip-Seq_ESCs_Mouse1.43127921
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.40243047
72TP63_22573176_ChIP-Seq_HFKS_Human1.40091024
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37568481
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37507599
75ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.36576556
76UTX_26944678_Chip-Seq_JUKART_Human1.35412327
77STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35339692
78TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.33488328
79GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.33053728
80RAD21_21589869_ChIP-Seq_MESCs_Mouse1.31240630
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31084405
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.31004777
83MYC_22102868_ChIP-Seq_BL_Human1.28267676
84CTCF_20526341_ChIP-Seq_ESCs_Human1.27517362
85* STAT1_17558387_ChIP-Seq_HELA_Human1.26245502
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25584238
87OCT4_20526341_ChIP-Seq_ESCs_Human1.25213613
88IRF8_27001747_Chip-Seq_BMDM_Mouse1.25048594
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24111510
90SMAD3_21741376_ChIP-Seq_HESCs_Human1.23823387
91P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.22911096
92JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.20947162
93EZH2_27294783_Chip-Seq_NPCs_Mouse1.20850091
94SCL_19346495_ChIP-Seq_HPC-7_Human1.19633394
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19103427
96JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18879038
97SOX2_18555785_Chip-Seq_ESCs_Mouse1.18671279
98EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.18302996
99MAF_26560356_Chip-Seq_TH1_Human1.18275773
100* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16739341
101FOXH1_21741376_ChIP-Seq_ESCs_Human1.15965810
102KDM2B_26808549_Chip-Seq_DND41_Human1.15789399
103SALL4_22934838_ChIP-ChIP_CD34+_Human1.14923720
104ELF1_20517297_ChIP-Seq_JURKAT_Human1.14912052
105CTCF_21964334_Chip-Seq_Bcells_Human1.13697364
106SMAD_19615063_ChIP-ChIP_OVARY_Human1.13319540
107CREB1_26743006_Chip-Seq_LNCaP_Human1.13159300
108EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13116717
109RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13116717
110SMC4_20622854_ChIP-Seq_HELA_Human1.12957326
111SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12507899
112KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10888595
113KDM2B_26808549_Chip-Seq_REH_Human1.10724898
114MYC_27129775_Chip-Seq_CORNEA_Mouse1.10528203
115MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10022336
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09977221
117SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09487588
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09425347
119PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09379478
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09231201
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09231201
122RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09008196
123PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08797068
124GATA3_21867929_ChIP-Seq_CD8_Mouse1.08640075
125SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08107649
126EZH2_27294783_Chip-Seq_ESCs_Mouse1.07799787
127SOX2_21211035_ChIP-Seq_LN229_Human1.06715862
128MYC_19829295_ChIP-Seq_ESCs_Human1.06316950
129CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05828174
130STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.05422851
131EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05115385
132TDRD3_21172665_ChIP-Seq_MCF-7_Human1.05048755
133Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04902531
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04774985
135P300_27268052_Chip-Seq_Bcells_Human1.04671649
136TAF2_19829295_ChIP-Seq_ESCs_Human1.03829809
137SPI1_20517297_ChIP-Seq_HL60_Human1.03767314
138KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03757542
139RUNX1_27457419_Chip-Seq_LIVER_Mouse1.03729966
140ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03269036
141CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02858905
142CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02573013
143RUNX1_27514584_Chip-Seq_MCF-7_Human1.02531597
144ELK4_26923725_Chip-Seq_MESODERM_Mouse1.01558128
145GATA1_19941827_ChIP-Seq_MEL_Mouse1.01180490
146ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01106770
147TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00110367
148RARB_24833708_ChIP-Seq_LIVER_Mouse0.99795676
149NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99738776
150TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.99461734
151EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99339240
152P53_21459846_ChIP-Seq_SAOS-2_Human0.98596090
153NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98008304
154SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97781067
155FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96768956
156* SOX2_22085726_ChIP-Seq_NPCs_Mouse0.96727216
157RUNX1_22412390_ChIP-Seq_EML_Mouse0.95888045
158RACK7_27058665_Chip-Seq_MCF-7_Human0.95812754
159RUNX_20019798_ChIP-Seq_JUKART_Human0.95585851
160MYC_19915707_ChIP-ChIP_AK7_Human0.95086397
161PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94357376
162GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93739509
163CSB_26484114_Chip-Seq_FIBROBLAST_Human0.93282794
164ERG_21242973_ChIP-ChIP_JURKAT_Human0.92762705
165KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92756901
166SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92366818
167TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92185468
168PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91915412
169EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90329624
170CRX_20693478_ChIP-Seq_RETINA_Mouse0.90153742
171ETS1_21867929_ChIP-Seq_TH2_Mouse0.89666377
172KLF4_19829295_ChIP-Seq_ESCs_Human0.89476761
173BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.88557959
174MYB_26560356_Chip-Seq_TH2_Human0.88492730
175* BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.87711976
176NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87668524
177SOX2_20726797_ChIP-Seq_SW620_Human0.87275827
178VDR_24763502_ChIP-Seq_THP-1_Human0.84783620
179STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84551523

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism7.46145377
2MP0005084_abnormal_gallbladder_morpholo7.32221418
3MP0003303_peritoneal_inflammation6.27592496
4MP0002254_reproductive_system_inflammat5.68932659
5MP0003195_calcinosis4.78125405
6MP0005058_abnormal_lysosome_morphology3.61738941
7MP0004043_abnormal_pH_regulation3.43094802
8MP0005410_abnormal_fertilization3.36628219
9MP0003136_yellow_coat_color3.17570972
10MP0002139_abnormal_hepatobiliary_system3.03142869
11MP0010234_abnormal_vibrissa_follicle2.80388906
12MP0001986_abnormal_taste_sensitivity2.80160472
13MP0005083_abnormal_biliary_tract2.78655022
14MP0000003_abnormal_adipose_tissue2.68385418
15MP0003252_abnormal_bile_duct2.41323995
16MP0005671_abnormal_response_to2.39690030
17MP0003566_abnormal_cell_adhesion2.19476117
18MP0005423_abnormal_somatic_nervous2.17235452
19MP0004185_abnormal_adipocyte_glucose2.16740535
20MP0003329_amyloid_beta_deposits2.16463505
21MP0002168_other_aberrant_phenotype2.15062144
22MP0003646_muscle_fatigue2.14655868
23MP0002928_abnormal_bile_duct2.11121126
24MP0004133_heterotaxia2.10117918
25MP0003300_gastrointestinal_ulcer2.09348271
26MP0000604_amyloidosis2.06033457
27MP0001853_heart_inflammation1.94209932
28MP0005448_abnormal_energy_balance1.93666480
29MP0004130_abnormal_muscle_cell1.89257252
30MP0002933_joint_inflammation1.88123265
31MP0005375_adipose_tissue_phenotype1.76845170
32MP0003878_abnormal_ear_physiology1.68672046
33MP0005377_hearing/vestibular/ear_phenot1.68672046
34MP0002876_abnormal_thyroid_physiology1.62753332
35MP0005451_abnormal_body_composition1.62562726
36MP0000470_abnormal_stomach_morphology1.61156802
37MP0000013_abnormal_adipose_tissue1.60729728
38MP0001765_abnormal_ion_homeostasis1.59834246
39MP0004381_abnormal_hair_follicle1.59778587
40MP0010329_abnormal_lipoprotein_level1.58977905
41MP0005174_abnormal_tail_pigmentation1.58646432
42MP0003763_abnormal_thymus_physiology1.57531643
43MP0003690_abnormal_glial_cell1.57337663
44MP0001270_distended_abdomen1.55232933
45MP0001968_abnormal_touch/_nociception1.51333117
46MP0000685_abnormal_immune_system1.46665616
47MP0006082_CNS_inflammation1.45783982
48MP0002089_abnormal_postnatal_growth/wei1.44350192
49MP0003943_abnormal_hepatobiliary_system1.41437593
50MP0005670_abnormal_white_adipose1.39960277
51MP0001501_abnormal_sleep_pattern1.39874927
52MP0002896_abnormal_bone_mineralization1.34488281
53MP0002009_preneoplasia1.33202758
54MP0001533_abnormal_skeleton_physiology1.31101577
55MP0005360_urolithiasis1.29657997
56MP0002736_abnormal_nociception_after1.29475252
57MP0002751_abnormal_autonomic_nervous1.27499966
58MP0000372_irregular_coat_pigmentation1.26664194
59MP0006072_abnormal_retinal_apoptosis1.26218983
60MP0005551_abnormal_eye_electrophysiolog1.25934855
61MP0003724_increased_susceptibility_to1.25125878
62MP0001958_emphysema1.24433289
63MP0002419_abnormal_innate_immunity1.22695066
64MP0001835_abnormal_antigen_presentation1.21744847
65MP0005666_abnormal_adipose_tissue1.21144666
66MP0005397_hematopoietic_system_phenotyp1.20854489
67MP0001545_abnormal_hematopoietic_system1.20854489
68MP0008438_abnormal_cutaneous_collagen1.20411508
69MP0003718_maternal_effect1.19901924
70MP0009379_abnormal_foot_pigmentation1.19802916
71MP0002420_abnormal_adaptive_immunity1.19354996
72MP0009643_abnormal_urine_homeostasis1.18028563
73MP0002452_abnormal_antigen_presenting1.17699534
74MP0002405_respiratory_system_inflammati1.14113106
75MP0003656_abnormal_erythrocyte_physiolo1.13916468
76MP0005365_abnormal_bile_salt1.13698628
77MP0005164_abnormal_response_to1.09611948
78MP0009785_altered_susceptibility_to1.08164175
79MP0003448_altered_tumor_morphology1.07866553
80MP0005220_abnormal_exocrine_pancreas1.06580764
81MP0005503_abnormal_tendon_morphology1.05169138
82MP0004134_abnormal_chest_morphology1.02707300
83MP0002998_abnormal_bone_remodeling1.02702007
84MP0002398_abnormal_bone_marrow1.02402308
85MP0008875_abnormal_xenobiotic_pharmacok1.00803402
86MP0002210_abnormal_sex_determination1.00324412
87MP0001929_abnormal_gametogenesis1.00209481
88MP0000703_abnormal_thymus_morphology0.99509764
89MP0000716_abnormal_immune_system0.97256700
90MP0000767_abnormal_smooth_muscle0.97180588
91MP0004264_abnormal_extraembryonic_tissu0.97097500
92MP0003191_abnormal_cellular_cholesterol0.95492716
93MP0009278_abnormal_bone_marrow0.95242119
94MP0002735_abnormal_chemical_nociception0.94323866
95MP0002722_abnormal_immune_system0.94244662
96MP0009384_cardiac_valve_regurgitation0.93901649
97MP0005584_abnormal_enzyme/coenzyme_acti0.93480788
98MP0002136_abnormal_kidney_physiology0.91050288
99MP0002429_abnormal_blood_cell0.90299950
100MP0000678_abnormal_parathyroid_gland0.90180166
101MP0001440_abnormal_grooming_behavior0.89007491
102MP0004858_abnormal_nervous_system0.88772528
103MP0009780_abnormal_chondrocyte_physiolo0.88250586
104MP0002148_abnormal_hypersensitivity_rea0.88059789
105MP0005000_abnormal_immune_tolerance0.86034299
106MP0005171_absent_coat_pigmentation0.85959790
107MP0005275_abnormal_skin_tensile0.85844471
108MP0001851_eye_inflammation0.85145569
109MP0002723_abnormal_immune_serum0.84759427
110MP0009764_decreased_sensitivity_to0.84508773
111MP0002118_abnormal_lipid_homeostasis0.83522667
112MP0005334_abnormal_fat_pad0.82856911
113MP0001756_abnormal_urination0.82356599
114MP0000534_abnormal_ureter_morphology0.81643153
115MP0002132_abnormal_respiratory_system0.80937915
116MP0003705_abnormal_hypodermis_morpholog0.80766838
117MP0000689_abnormal_spleen_morphology0.80754484
118MP0006054_spinal_hemorrhage0.80491978
119MP0003045_fibrosis0.79601471
120MP0005025_abnormal_response_to0.79477090
121MP0000343_altered_response_to0.79055911
122MP0005319_abnormal_enzyme/_coenzyme0.78984414
123MP0003221_abnormal_cardiomyocyte_apopto0.78941777
124MP0010368_abnormal_lymphatic_system0.78430777
125MP0003075_altered_response_to0.78352314
126MP0000015_abnormal_ear_pigmentation0.78299410
127MP0002693_abnormal_pancreas_physiology0.78168298
128MP0005379_endocrine/exocrine_gland_phen0.78018050
129MP0003698_abnormal_male_reproductive0.77759817
130MP0001819_abnormal_immune_cell0.77640135
131MP0008569_lethality_at_weaning0.77584194
132MP0000249_abnormal_blood_vessel0.76958035
133MP0005636_abnormal_mineral_homeostasis0.76824998
134MP0005623_abnormal_meninges_morphology0.76766087
135MP0008872_abnormal_physiological_respon0.75786245
136MP0001790_abnormal_immune_system0.75675690
137MP0005387_immune_system_phenotype0.75675690
138MP0003638_abnormal_response/metabolism_0.75461449
139MP0002909_abnormal_adrenal_gland0.75261417
140MP0001800_abnormal_humoral_immune0.75065204
141MP0005395_other_phenotype0.74397344
142MP0005085_abnormal_gallbladder_physiolo0.74177293
143MP0001845_abnormal_inflammatory_respons0.74070753
144MP0000609_abnormal_liver_physiology0.73298362
145MP0005464_abnormal_platelet_physiology0.72162967
146MP0001879_abnormal_lymphatic_vessel0.72120045
147MP0003436_decreased_susceptibility_to0.71978012
148MP0003693_abnormal_embryo_hatching0.71319443
149MP0003091_abnormal_cell_migration0.69173592
150MP0005310_abnormal_salivary_gland0.68941956
151MP0000371_diluted_coat_color0.68702608
152MP0002161_abnormal_fertility/fecundity0.68516512
153MP0000858_altered_metastatic_potential0.68243154
154MP0002113_abnormal_skeleton_development0.68169634
155MP0002971_abnormal_brown_adipose0.68012851
156MP0005332_abnormal_amino_acid0.67501580
157MP0008469_abnormal_protein_level0.67205018
158MP0009840_abnormal_foam_cell0.67181091
159MP0004947_skin_inflammation0.66801822
160MP0001529_abnormal_vocalization0.66731278
161MP0003806_abnormal_nucleotide_metabolis0.66424538
162MP0004019_abnormal_vitamin_homeostasis0.65509884
163MP0002138_abnormal_hepatobiliary_system0.65420256
164MP0003866_abnormal_defecation0.65382162
165MP0010155_abnormal_intestine_physiology0.65212157
166MP0002095_abnormal_skin_pigmentation0.64496649
167MP0005076_abnormal_cell_differentiation0.64437980
168MP0009115_abnormal_fat_cell0.62402939
169MP0001905_abnormal_dopamine_level0.61043930
170MP0002277_abnormal_respiratory_mucosa0.57694779

Predicted human phenotypes

RankGene SetZ-score
1Amelogenesis imperfecta (HP:0000705)6.84094305
2Myocardial infarction (HP:0001658)5.28940746
3Polyuria (HP:0000103)4.98302192
4Vascular calcification (HP:0004934)4.66455444
5Attenuation of retinal blood vessels (HP:0007843)4.60495454
6Overgrowth (HP:0001548)4.49310678
7Abnormality of dental color (HP:0011073)4.45928361
8Hypophosphatemic rickets (HP:0004912)4.37273787
9Cardiovascular calcification (HP:0011915)4.33300060
10Abnormal urine output (HP:0012590)4.19927164
11Abnormality of calcium-phosphate metabolism (HP:0100530)4.17282804
12Abnormality of renal resorption (HP:0011038)4.16610095
13Recurrent gram-negative bacterial infections (HP:0005420)4.13520423
14Absent rod-and cone-mediated responses on ERG (HP:0007688)4.11508854
15Decreased central vision (HP:0007663)3.91841535
16Facial shape deformation (HP:0011334)3.88224528
17Potter facies (HP:0002009)3.88224528
18Pendular nystagmus (HP:0012043)3.84309286
19Agitation (HP:0000713)3.78919996
20Complement deficiency (HP:0004431)3.52755982
21Abnormality of renal excretion (HP:0011036)3.48356702
22Round ear (HP:0100830)3.26869288
23Malnutrition (HP:0004395)3.23303707
24Mutism (HP:0002300)3.19526326
25Eczematoid dermatitis (HP:0000976)3.17380978
26Neurofibrillary tangles (HP:0002185)3.16592302
27Panhypogammaglobulinemia (HP:0003139)3.12159599
28Hypoproteinemia (HP:0003075)3.05088321
29Abnormality of midbrain morphology (HP:0002418)3.02251382
30Molar tooth sign on MRI (HP:0002419)3.02251382
31Widely patent fontanelles and sutures (HP:0004492)3.00546284
32Choroideremia (HP:0001139)2.98340316
33Autoimmune thrombocytopenia (HP:0001973)2.98009093
34Abnormality of the dental pulp (HP:0006479)2.93447707
35Cerebral inclusion bodies (HP:0100314)2.91029077
36Intestinal fistula (HP:0100819)2.78254433
37Personality changes (HP:0000751)2.76774028
38IgM deficiency (HP:0002850)2.68701157
39Lip pit (HP:0100267)2.65962710
40Rickets (HP:0002748)2.65273413
41Depressed nasal tip (HP:0000437)2.63955399
42Abnormality of the fingertips (HP:0001211)2.63484276
43Abnormality of the costochondral junction (HP:0000919)2.60154836
44Delayed epiphyseal ossification (HP:0002663)2.58177162
45Disinhibition (HP:0000734)2.55208425
46Hypoalphalipoproteinemia (HP:0003233)2.55014142
47Abnormality of complement system (HP:0005339)2.54927896
48Abnormality of the fovea (HP:0000493)2.54267886
49Toxemia of pregnancy (HP:0100603)2.54225731
50Alveolar cell carcinoma (HP:0006519)2.52547148
51Abnormality of the pons (HP:0007361)2.50945785
52Epiphyseal dysplasia (HP:0002656)2.50380069
53Infantile muscular hypotonia (HP:0008947)2.49671695
54Abnormality of the renal collecting system (HP:0004742)2.49151786
55Abnormality of DNA repair (HP:0003254)2.47837959
56Nephronophthisis (HP:0000090)2.47478550
57Hypoplasia of the pons (HP:0012110)2.44984116
58Abnormal delayed hypersensitivity skin test (HP:0002963)2.44773058
59Restlessness (HP:0000711)2.43121364
60Sparse lateral eyebrow (HP:0005338)2.42874792
61Abnormal tarsal ossification (HP:0008369)2.42833049
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.40909177
63Congenital stationary night blindness (HP:0007642)2.40519981
64Recurrent bacterial skin infections (HP:0005406)2.39997153
65Agammaglobulinemia (HP:0004432)2.38473191
66Duplicated collecting system (HP:0000081)2.37743623
67Metaphyseal cupping (HP:0003021)2.37681709
68Bony spicule pigmentary retinopathy (HP:0007737)2.37094911
69Oligomenorrhea (HP:0000876)2.36374529
70Abnormality of transition element cation homeostasis (HP:0011030)2.36085929
71Prominent nose (HP:0000448)2.35523999
72Vacuolated lymphocytes (HP:0001922)2.35405141
73Neoplasm of the tracheobronchial system (HP:0100552)2.34403696
74Acanthosis nigricans (HP:0000956)2.33730276
75Increased cerebral lipofuscin (HP:0011813)2.33208133
76Recurrent cutaneous fungal infections (HP:0011370)2.29587703
77Chronic mucocutaneous candidiasis (HP:0002728)2.29587703
78Xanthomatosis (HP:0000991)2.28289747
79Neoplasm of the heart (HP:0100544)2.26485646
80Ureteral stenosis (HP:0000071)2.23791763
81Hemorrhage of the eye (HP:0011885)2.23670026
82Abnormality of macrophages (HP:0004311)2.23260644
83Acanthocytosis (HP:0001927)2.22508960
84Increased neuronal autofluorescent lipopigment (HP:0002074)2.22429561
85Abnormality of purine metabolism (HP:0004352)2.21449879
86Enlarged epiphyses (HP:0010580)2.19899810
87Progressive neurologic deterioration (HP:0002344)2.18945784
88Hyporeflexia of lower limbs (HP:0002600)2.18383574
89Tachypnea (HP:0002789)2.17550734
90Supranuclear gaze palsy (HP:0000605)2.16765055
91Abnormality of the common coagulation pathway (HP:0010990)2.15908199
92Acute hepatic failure (HP:0006554)2.14934390
93Easy fatigability (HP:0003388)2.14004118
94Protuberant abdomen (HP:0001538)2.12746170
95Osteomalacia (HP:0002749)2.09684263
96Reduced subcutaneous adipose tissue (HP:0003758)2.07933436
97Intention tremor (HP:0002080)2.06596541
98Recurrent fungal infections (HP:0002841)2.06581530
99Ureteral obstruction (HP:0006000)2.04227036
100Abnormal number of erythroid precursors (HP:0012131)2.03569632
101Increased corneal curvature (HP:0100692)2.03311868
102Keratoconus (HP:0000563)2.03311868
103Insulin-resistant diabetes mellitus (HP:0000831)2.02631265
104Tubular atrophy (HP:0000092)2.00761460
105Choreoathetosis (HP:0001266)2.00337162
106Severe combined immunodeficiency (HP:0004430)2.00247472
107Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.00114550
108Hypoparathyroidism (HP:0000829)1.99456036
109Myopathic facies (HP:0002058)1.99300542
110Abnormality of the renal medulla (HP:0100957)1.97197196
111Abnormality of the neuromuscular junction (HP:0003398)1.96747476
112Fatigable weakness (HP:0003473)1.96747476
113Macular degeneration (HP:0000608)1.96477945
114Nasal polyposis (HP:0100582)1.95228188
115Type II lissencephaly (HP:0007260)1.94129565
116Absent thumb (HP:0009777)1.93458314
117Ectopia lentis (HP:0001083)1.93059206
118Recurrent abscess formation (HP:0002722)1.92345555
119Dysostosis multiplex (HP:0000943)1.91899542
120Flat acetabular roof (HP:0003180)1.91650266
121Aplasia of the musculature (HP:0100854)1.91479604
122Abnormal rod and cone electroretinograms (HP:0008323)1.91128607
123Apathy (HP:0000741)1.90807873
124Colitis (HP:0002583)1.90708735
125Segmental peripheral demyelination/remyelination (HP:0003481)1.90556949
126Deep venous thrombosis (HP:0002625)1.90116091
127Type 2 muscle fiber atrophy (HP:0003554)1.89977020
128Cortical dysplasia (HP:0002539)1.89038135
129Systemic lupus erythematosus (HP:0002725)1.86567446
130Small epiphyses (HP:0010585)1.85864396
131Hypertriglyceridemia (HP:0002155)1.83948209
132Severe visual impairment (HP:0001141)1.83879459
133T lymphocytopenia (HP:0005403)1.83149132
134Increased connective tissue (HP:0009025)1.83082268
135Petechiae (HP:0000967)1.82110193
136Polar cataract (HP:0010696)1.80968871
137Abnormality of the femoral head (HP:0003368)1.80636247
138Abnormality of urine glucose concentration (HP:0011016)1.79904454
139Glycosuria (HP:0003076)1.79904454
140Diminished motivation (HP:0000745)1.79593907
141Wide cranial sutures (HP:0010537)1.79560389
142Ovoid vertebral bodies (HP:0003300)1.78582704
143J-shaped sella turcica (HP:0002680)1.78009834
144Ectopic kidney (HP:0000086)1.76662513
145Hyperphosphatemia (HP:0002905)1.76472656
146Mucopolysacchariduria (HP:0008155)1.74787153
147Urinary glycosaminoglycan excretion (HP:0003541)1.74787153
148Abnormality of the nasal mucosa (HP:0000433)1.74587663
149Broad face (HP:0000283)1.74587303
150Polydipsia (HP:0001959)1.74027993
151Abnormal drinking behavior (HP:0030082)1.74027993
152Joint stiffness (HP:0001387)1.73484525
153Peripheral demyelination (HP:0011096)1.73294053
154Deformed sella turcica (HP:0002681)1.72744472
155Absent frontal sinuses (HP:0002688)1.72588434
156Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.72086711
157Increased variability in muscle fiber diameter (HP:0003557)1.71995416
158Gastrointestinal infarctions (HP:0005244)1.71717476
159Muscle fiber atrophy (HP:0100295)1.71647106
160Impulsivity (HP:0100710)1.71259853
161Abnormal foot bone ossification (HP:0010675)1.71075781
162Irregular epiphyses (HP:0010582)1.70999866
163Hemiplegia (HP:0002301)1.70960502
164Self-mutilation (HP:0000742)1.70892950
165Esophageal varix (HP:0002040)1.70845813
166Abnormal urine phosphate concentration (HP:0012599)1.70630514
167Difficulty running (HP:0009046)1.69789733
168Hyperglycemia (HP:0003074)1.69582594
169Abnormality of T cells (HP:0002843)1.69388167
170Hyperphosphaturia (HP:0003109)1.68475323
171Rib fusion (HP:0000902)1.68361841
172Short 5th finger (HP:0009237)1.68246244
173Poikiloderma (HP:0001029)1.68176751
174Aplasia/Hypoplasia of the macula (HP:0008059)1.67918215
175Exercise-induced myalgia (HP:0003738)1.67469351
176Mesangial abnormality (HP:0001966)1.66661779
177Carpal bone hypoplasia (HP:0001498)1.66617648
178Hypopigmentation of the fundus (HP:0007894)1.66429365
179Intrahepatic cholestasis (HP:0001406)1.66075878
180Abnormality of lateral ventricle (HP:0030047)1.65961991
181Hypoplastic ischia (HP:0003175)1.65775836
182Large earlobe (HP:0009748)1.65495662
183Thin bony cortex (HP:0002753)1.65438610
184Gout (HP:0001997)1.64617630
185Drooling (HP:0002307)1.64417766
186Excessive salivation (HP:0003781)1.64355770
187Peritonitis (HP:0002586)1.62667009
188Polygenic inheritance (HP:0010982)1.59884828
189Premature rupture of membranes (HP:0001788)1.59669006
190Hypophosphatemia (HP:0002148)1.59577594
191Metaphyseal irregularity (HP:0003025)1.59129490
192Inappropriate behavior (HP:0000719)1.58215841
193Abnormality of the lumbar spine (HP:0100712)1.56353783
194Flattened epiphyses (HP:0003071)1.56004846
195Abdominal distention (HP:0003270)1.55754958

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK27.29803162
2BMPR26.87263750
3MAP4K16.03660532
4MST43.65785589
5DMPK3.12268835
6EPHB13.05664800
7ERN13.01777338
8TRIB32.40069528
9SIK12.23094229
10LRRK22.17313033
11TXK2.09840416
12PTK61.94588740
13MAP3K111.92073018
14MUSK1.91154165
15LMTK21.87943287
16FGFR41.86873564
17GSK3A1.82354986
18STK101.76029988
19VRK21.65559224
20LATS21.63126274
21TLK11.61409139
22RIPK41.59219114
23FER1.57691099
24ERBB31.54906243
25PDGFRA1.54172669
26ACVR1B1.52333744
27TAOK31.46824256
28TESK21.46144729
29PLK21.41302687
30EPHA21.41064891
31CDC42BPA1.39944067
32NEK21.39438937
33TBK11.33151212
34FGFR31.32988534
35BMX1.28625908
36CDK121.27349988
37GRK61.25398325
38EPHA31.24835545
39FLT31.23041692
40RET1.21792795
41NTRK11.20728667
42IKBKB1.20181097
43PTK2B1.19922474
44MAPK151.13627672
45DDR21.13007954
46PKN21.12397426
47PAK41.12300465
48IKBKE1.07461395
49IRAK11.01976071
50EPHB21.00544405
51BLK1.00404518
52IRAK31.00303215
53IRAK41.00128241
54ADRBK21.00010542
55WNK40.99188104
56HIPK20.98145830
57MAP2K60.97907162
58FGFR20.96792604
59STK38L0.96787059
60ITK0.95840735
61PRKD20.95821290
62MAP3K20.95314407
63CHUK0.95209869
64JAK10.93949350
65STK160.93086269
66PLK40.92942367
67RPS6KA60.91513205
68INSR0.90261087
69ZAK0.90068852
70BTK0.89742945
71TNK20.89010271
72STK390.87408647
73MAP3K140.87196597
74FRK0.84846446
75NME20.82609234
76ALK0.78590181
77KDR0.78550598
78NME10.78340535
79PAK30.78208766
80PRKCH0.78113053
81PTK20.75821480
82RPS6KL10.75679639
83RPS6KC10.75679639
84GRK10.75575528
85TTN0.74657707
86TESK10.74333477
87MYLK0.73509506
88ZAP700.72489282
89MAP3K50.72310091
90JAK20.69981579
91MAP3K70.69486429
92MAP3K60.69275488
93TGFBR20.69153218
94MAP2K10.68710612
95SIK20.68110063
96KIT0.68016591
97PDGFRB0.66797504
98BCKDK0.66402458
99CDK60.63819658
100TYRO30.62064771
101NEK90.61921557
102ADRBK10.60663057
103JAK30.60311974
104STK240.59909773
105LYN0.59192740
106SMG10.58997170
107IRAK20.58211749
108WNK10.57007533
109MAP3K120.54956016
110SYK0.54569496
111CSK0.53562536
112MAPKAPK30.53331202
113LCK0.53188907
114PAK20.50682363
115PRKAA10.50423071
116CDK90.50224249
117CDK80.49878954
118HCK0.49440230
119PKN10.48046033
120WNK30.48017826
121PDK30.47712547
122PDK40.47712547
123TYK20.47671015
124CAMK1G0.47665227
125STK30.47507237
126MAPK110.47028001
127PRKD10.46820594
128PRKCQ0.46434576
129BMPR1B0.44458374
130PIM10.44163792
131EEF2K0.43875788
132MELK0.43257572
133MARK30.41516657
134RIPK10.40354126
135ICK0.39586462
136INSRR0.39069492
137TAOK10.38791302
138VRK10.38309169
139TGFBR10.38286416
140FGFR10.38192193
141CAMK10.37840241
142PRKACG0.37319033
143TEC0.37280894
144AKT30.37219263
145STK380.36986921
146PDK10.36525352
147PRKACA0.36302822
148CCNB10.35913377
149CHEK20.35671451
150NTRK30.35378273
151MAPK30.35112291
152RPS6KA10.34449166
153CDK50.33507824
154MTOR0.33361555
155IGF1R0.33360176
156PRKG20.32864353
157SGK30.32790290
158EGFR0.31884231
159ILK0.31811172
160SRC0.31169956
161GSK3B0.29906960
162CDK70.29503203
163MAP3K10.28722860
164GRK70.28676171
165MARK20.28659858
166RPS6KA20.28006376
167PRKCA0.26218850
168MAPK130.25824527

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.87565460
2Sulfur relay system_Homo sapiens_hsa041224.69337557
3Glutathione metabolism_Homo sapiens_hsa004804.65992246
4African trypanosomiasis_Homo sapiens_hsa051434.44108547
5Arachidonic acid metabolism_Homo sapiens_hsa005903.99808579
6Thyroid hormone synthesis_Homo sapiens_hsa049183.64782426
7Linoleic acid metabolism_Homo sapiens_hsa005913.55364134
8Tryptophan metabolism_Homo sapiens_hsa003803.36859123
9Primary immunodeficiency_Homo sapiens_hsa053402.88989242
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.58606579
11Pancreatic secretion_Homo sapiens_hsa049722.47733421
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.26245244
13Ether lipid metabolism_Homo sapiens_hsa005651.95180776
14Fatty acid degradation_Homo sapiens_hsa000711.79757817
15PPAR signaling pathway_Homo sapiens_hsa033201.78848919
16Fatty acid metabolism_Homo sapiens_hsa012121.78595264
17Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.76058632
18Taste transduction_Homo sapiens_hsa047421.69690484
19Sulfur metabolism_Homo sapiens_hsa009201.69567552
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.68364878
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.50099068
22Morphine addiction_Homo sapiens_hsa050321.39423468
23Lysosome_Homo sapiens_hsa041421.38066540
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34604453
25Phototransduction_Homo sapiens_hsa047441.34194578
26Arginine biosynthesis_Homo sapiens_hsa002201.33235293
27Fatty acid biosynthesis_Homo sapiens_hsa000611.23207249
28Insulin secretion_Homo sapiens_hsa049111.20650198
29Salivary secretion_Homo sapiens_hsa049701.18570849
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17896163
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17461460
32Longevity regulating pathway - mammal_Homo sapiens_hsa042111.14364254
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.14150239
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12386469
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11842738
36Complement and coagulation cascades_Homo sapiens_hsa046101.09847361
37Glycerolipid metabolism_Homo sapiens_hsa005611.09799333
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08941382
39Glutamatergic synapse_Homo sapiens_hsa047241.07532306
40Graft-versus-host disease_Homo sapiens_hsa053321.05683412
41Renin secretion_Homo sapiens_hsa049241.03224562
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02395554
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02354728
44Cocaine addiction_Homo sapiens_hsa050301.00468556
45Calcium signaling pathway_Homo sapiens_hsa040200.98261072
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96041817
47Estrogen signaling pathway_Homo sapiens_hsa049150.89429406
48Dorso-ventral axis formation_Homo sapiens_hsa043200.88578809
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88071823
50Hematopoietic cell lineage_Homo sapiens_hsa046400.87532226
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.87518765
52NF-kappa B signaling pathway_Homo sapiens_hsa040640.87392452
53Oxytocin signaling pathway_Homo sapiens_hsa049210.86048044
54Staphylococcus aureus infection_Homo sapiens_hsa051500.83243327
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81176854
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80641683
57Collecting duct acid secretion_Homo sapiens_hsa049660.79313038
58Vibrio cholerae infection_Homo sapiens_hsa051100.78962894
59T cell receptor signaling pathway_Homo sapiens_hsa046600.76941611
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76814299
61Gastric acid secretion_Homo sapiens_hsa049710.74289484
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74260429
63Protein digestion and absorption_Homo sapiens_hsa049740.72117284
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.71941766
65Propanoate metabolism_Homo sapiens_hsa006400.70863496
66Oxidative phosphorylation_Homo sapiens_hsa001900.70159386
67beta-Alanine metabolism_Homo sapiens_hsa004100.70118373
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.69431240
69Phenylalanine metabolism_Homo sapiens_hsa003600.69076216
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67992010
71Ovarian steroidogenesis_Homo sapiens_hsa049130.66929384
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66801771
73Autoimmune thyroid disease_Homo sapiens_hsa053200.66777109
74Chemokine signaling pathway_Homo sapiens_hsa040620.66714793
75Dilated cardiomyopathy_Homo sapiens_hsa054140.65739473
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65354871
77Serotonergic synapse_Homo sapiens_hsa047260.64948503
78Starch and sucrose metabolism_Homo sapiens_hsa005000.63928432
79Osteoclast differentiation_Homo sapiens_hsa043800.63676614
80RNA degradation_Homo sapiens_hsa030180.62958751
81Leishmaniasis_Homo sapiens_hsa051400.62814200
82Ribosome_Homo sapiens_hsa030100.62225800
83Basal transcription factors_Homo sapiens_hsa030220.62164075
84N-Glycan biosynthesis_Homo sapiens_hsa005100.61106053
85Prion diseases_Homo sapiens_hsa050200.60601856
86Allograft rejection_Homo sapiens_hsa053300.60572205
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60534344
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60162851
89Melanogenesis_Homo sapiens_hsa049160.60123695
90Long-term potentiation_Homo sapiens_hsa047200.59717127
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59447131
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.58343307
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58168246
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.57457058
95Pertussis_Homo sapiens_hsa051330.54465394
96RNA polymerase_Homo sapiens_hsa030200.53907743
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51677359
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50907830
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50352152
100Bile secretion_Homo sapiens_hsa049760.50180818
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49243543
102Hepatitis C_Homo sapiens_hsa051600.49066652
103Regulation of autophagy_Homo sapiens_hsa041400.48786772
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48314301
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48119158
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47935330
107GABAergic synapse_Homo sapiens_hsa047270.46577465
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.46249496
109Circadian entrainment_Homo sapiens_hsa047130.45787793
110Amphetamine addiction_Homo sapiens_hsa050310.44439142
111Circadian rhythm_Homo sapiens_hsa047100.43178167
112Type I diabetes mellitus_Homo sapiens_hsa049400.43134203
113Olfactory transduction_Homo sapiens_hsa047400.42937678
114Purine metabolism_Homo sapiens_hsa002300.42364020
115Vitamin B6 metabolism_Homo sapiens_hsa007500.42305680
116Glioma_Homo sapiens_hsa052140.41645583
117Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41189774
118Arginine and proline metabolism_Homo sapiens_hsa003300.40790796
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40320304
120Parkinsons disease_Homo sapiens_hsa050120.40302371
121Gap junction_Homo sapiens_hsa045400.39540981
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.39494722
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39266156
124HTLV-I infection_Homo sapiens_hsa051660.39006168
125Phagosome_Homo sapiens_hsa041450.38751139
126Insulin resistance_Homo sapiens_hsa049310.38565663
127Rheumatoid arthritis_Homo sapiens_hsa053230.38504290
128Fat digestion and absorption_Homo sapiens_hsa049750.38064742
129Cyanoamino acid metabolism_Homo sapiens_hsa004600.37587117
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37129955
131Histidine metabolism_Homo sapiens_hsa003400.36257804
132Tuberculosis_Homo sapiens_hsa051520.35923486
133Pyruvate metabolism_Homo sapiens_hsa006200.35400786
134Malaria_Homo sapiens_hsa051440.35045022
135Platelet activation_Homo sapiens_hsa046110.33263028
136Nicotine addiction_Homo sapiens_hsa050330.32992251
1372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32863435
138Vitamin digestion and absorption_Homo sapiens_hsa049770.32704012
139AMPK signaling pathway_Homo sapiens_hsa041520.32305280
140Peroxisome_Homo sapiens_hsa041460.32218668
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31403449
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31330967
143Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31067893
144Huntingtons disease_Homo sapiens_hsa050160.30392287
145Synaptic vesicle cycle_Homo sapiens_hsa047210.30266611
146Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30197109
147Fanconi anemia pathway_Homo sapiens_hsa034600.30161491
148Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29926449
149TNF signaling pathway_Homo sapiens_hsa046680.29744795
150MAPK signaling pathway_Homo sapiens_hsa040100.29392532
151Phospholipase D signaling pathway_Homo sapiens_hsa040720.28411604
152Renin-angiotensin system_Homo sapiens_hsa046140.28258748
153cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28036025
154B cell receptor signaling pathway_Homo sapiens_hsa046620.27520541
155cAMP signaling pathway_Homo sapiens_hsa040240.26621421
156Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25113630
157Proteoglycans in cancer_Homo sapiens_hsa052050.24619692
158Toxoplasmosis_Homo sapiens_hsa051450.22951304
159GnRH signaling pathway_Homo sapiens_hsa049120.22832587
160ABC transporters_Homo sapiens_hsa020100.22759898
161Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22724235
162Antigen processing and presentation_Homo sapiens_hsa046120.22709418
163Cholinergic synapse_Homo sapiens_hsa047250.20861878
164Glucagon signaling pathway_Homo sapiens_hsa049220.20830331
165Focal adhesion_Homo sapiens_hsa045100.20443509

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