RNASE11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.51048549
2multicellular organism reproduction (GO:0032504)8.27481232
3binding of sperm to zona pellucida (GO:0007339)7.83942035
4sperm-egg recognition (GO:0035036)7.82265428
5plasma membrane fusion (GO:0045026)7.73867262
6sperm capacitation (GO:0048240)7.54996244
7axonemal dynein complex assembly (GO:0070286)7.36813360
8reproduction (GO:0000003)6.95995819
9regulation of phosphoprotein phosphatase activity (GO:0043666)6.94519612
10microtubule depolymerization (GO:0007019)6.91038707
11protein targeting to Golgi (GO:0000042)6.89694027
12chromosome condensation (GO:0030261)6.88717039
13DNA packaging (GO:0006323)6.66742204
14motile cilium assembly (GO:0044458)6.63823670
15establishment of protein localization to Golgi (GO:0072600)6.61496577
16cell-cell recognition (GO:0009988)6.59727169
17calcium ion-dependent exocytosis (GO:0017156)6.49929577
18phosphatidylethanolamine biosynthetic process (GO:0006646)6.47308143
19cilium or flagellum-dependent cell motility (GO:0001539)6.42038737
20retrograde transport, vesicle recycling within Golgi (GO:0000301)6.39753030
21protein polyglutamylation (GO:0018095)6.38209016
22male meiosis (GO:0007140)6.16566878
23spermatid nucleus differentiation (GO:0007289)6.14959600
24microtubule polymerization or depolymerization (GO:0031109)6.00863924
25single fertilization (GO:0007338)5.95992150
26phosphatidylethanolamine metabolic process (GO:0046337)5.95245161
27spermatogenesis (GO:0007283)5.94228870
28male gamete generation (GO:0048232)5.92019559
29single strand break repair (GO:0000012)5.78323352
30rRNA methylation (GO:0031167)5.78013128
31negative regulation of inclusion body assembly (GO:0090084)5.69456954
32epithelial cilium movement (GO:0003351)5.59485789
33centriole assembly (GO:0098534)5.59475664
34centriole replication (GO:0007099)5.57114124
35germ cell development (GO:0007281)5.49353090
36gamete generation (GO:0007276)5.45477986
37protein-DNA complex disassembly (GO:0032986)5.36663704
38nucleosome disassembly (GO:0006337)5.36663704
39organic cation transport (GO:0015695)5.32246606
40response to pheromone (GO:0019236)5.29604952
41cellular process involved in reproduction in multicellular organism (GO:0022412)4.92869690
42polyamine biosynthetic process (GO:0006596)4.91109843
43protein localization to Golgi apparatus (GO:0034067)4.88523394
44fertilization (GO:0009566)4.83168356
45microtubule severing (GO:0051013)4.82662307
46rRNA modification (GO:0000154)4.80755571
47cilium movement (GO:0003341)4.76000277
48positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.60578064
49regulation of cilium movement (GO:0003352)4.59270270
50regulation of Rab GTPase activity (GO:0032313)4.55507806
51positive regulation of Rab GTPase activity (GO:0032851)4.55507806
52regulation of centriole replication (GO:0046599)4.44307345
53sexual reproduction (GO:0019953)4.41945331
54multicellular organismal reproductive process (GO:0048609)4.38930122
55positive regulation of catecholamine secretion (GO:0033605)4.34855377
56seminiferous tubule development (GO:0072520)4.34243149
57response to acidic pH (GO:0010447)4.31896981
58regulation of transcription involved in cell fate commitment (GO:0060850)4.22090686
59ventricular system development (GO:0021591)4.15625073
60coenzyme catabolic process (GO:0009109)4.04772129
61regulation of inclusion body assembly (GO:0090083)3.94595530
62male sex determination (GO:0030238)3.78104272
63cell wall macromolecule metabolic process (GO:0044036)3.75779043
64RNA destabilization (GO:0050779)3.72027217
65cellular response to pH (GO:0071467)3.68590424
66histone H3-K9 demethylation (GO:0033169)3.61754249
67histone exchange (GO:0043486)3.55653257
68cellular ketone body metabolic process (GO:0046950)3.46414055
69nucleus organization (GO:0006997)3.44261029
70cell wall macromolecule catabolic process (GO:0016998)3.37204950
71synapsis (GO:0007129)3.34611968
72acrosome assembly (GO:0001675)3.30684985
73microtubule nucleation (GO:0007020)3.28815085
74detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.28631613
75musculoskeletal movement (GO:0050881)3.28354961
76multicellular organismal movement (GO:0050879)3.28354961
77mitochondrion degradation (GO:0000422)3.28142510
78cellular biogenic amine biosynthetic process (GO:0042401)3.27170504
79epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.22359599
80cell recognition (GO:0008037)3.20955501
81piRNA metabolic process (GO:0034587)3.19066944
82amine biosynthetic process (GO:0009309)3.15780421
83regulation of ARF GTPase activity (GO:0032312)3.12396724
84potassium ion export (GO:0071435)3.03950797
85ketone body metabolic process (GO:1902224)3.03799702
86positive regulation of glycolytic process (GO:0045821)3.03060500
87meiotic nuclear division (GO:0007126)3.01764708
88receptor recycling (GO:0001881)3.00006109
89chromatin silencing (GO:0006342)2.99673923
90multicellular organismal development (GO:0007275)2.96436893
91glomerular visceral epithelial cell development (GO:0072015)2.96381769
92DNA methylation involved in gamete generation (GO:0043046)2.95781437
93oogenesis (GO:0048477)2.95267262
94Leydig cell differentiation (GO:0033327)2.88192149
95relaxation of smooth muscle (GO:0044557)2.84136706
96chromosome organization involved in meiosis (GO:0070192)2.81310387
97regulation of microtubule-based movement (GO:0060632)2.80274652
98sperm motility (GO:0030317)12.5604270
99acrosome reaction (GO:0007340)12.1663756
100fusion of sperm to egg plasma membrane (GO:0007342)10.1189097

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.54616103
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.79975222
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.20876666
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.97063316
5EZH2_22144423_ChIP-Seq_EOC_Human2.79975427
6POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.57533570
7TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.57533570
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.53306703
9FUS_26573619_Chip-Seq_HEK293_Human2.49047565
10* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.39995295
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.31991458
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.31860308
13IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.31859370
14CBP_20019798_ChIP-Seq_JUKART_Human2.31859370
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.25291356
16ARNT_22903824_ChIP-Seq_MCF-7_Human2.00095208
17RAC3_21632823_ChIP-Seq_H3396_Human1.98282504
18NANOG_20526341_ChIP-Seq_ESCs_Human1.96505010
19IGF1R_20145208_ChIP-Seq_DFB_Human1.96207999
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93342401
21ERA_21632823_ChIP-Seq_H3396_Human1.88169192
22ER_23166858_ChIP-Seq_MCF-7_Human1.87824141
23WDR5_24793694_ChIP-Seq_LNCAP_Human1.79218286
24CTCF_27219007_Chip-Seq_Bcells_Human1.77072006
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.76371123
26AR_21572438_ChIP-Seq_LNCaP_Human1.75369063
27SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.70347188
28MYC_19829295_ChIP-Seq_ESCs_Human1.68727722
29SMC4_20622854_ChIP-Seq_HELA_Human1.66591577
30EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.65303445
31OCT4_20526341_ChIP-Seq_ESCs_Human1.62174773
32ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61828408
33RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.59931317
34EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.56946023
35SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.54124338
36SMAD4_21741376_ChIP-Seq_EPCs_Human1.52522462
37SMAD3_21741376_ChIP-Seq_EPCs_Human1.52123248
38TP53_18474530_ChIP-ChIP_U2OS_Human1.47203563
39TBL1_22424771_ChIP-Seq_293T_Human1.45682787
40AHR_22903824_ChIP-Seq_MCF-7_Human1.43585887
41P300_19829295_ChIP-Seq_ESCs_Human1.41452286
42CTCF_20526341_ChIP-Seq_ESCs_Human1.40470175
43AR_25329375_ChIP-Seq_VCAP_Human1.39770151
44KLF5_20875108_ChIP-Seq_MESCs_Mouse1.38691067
45DROSHA_22980978_ChIP-Seq_HELA_Human1.36154179
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.33996125
47OCT1_27270436_Chip-Seq_PROSTATE_Human1.33969845
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.33829205
49* ERG_20517297_ChIP-Seq_VCAP_Human1.33442666
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31868674
51CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.31711203
52HNFA_21074721_ChIP-Seq_CACO-2_Human1.30674716
53BCL6_27268052_Chip-Seq_Bcells_Human1.30366479
54CBX2_22325352_ChIP-Seq_293T-Rex_Human1.29929613
55PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.28998122
56GBX2_23144817_ChIP-Seq_PC3_Human1.28770391
57P68_20966046_ChIP-Seq_HELA_Human1.28420687
58RBPJ_21746931_ChIP-Seq_IB4_Human1.27611738
59RUNX2_22187159_ChIP-Seq_PCA_Human1.27112315
60P300_27268052_Chip-Seq_Bcells_Human1.25966464
61NFYB_21822215_ChIP-Seq_K562_Human1.24595739
62SMAD4_21799915_ChIP-Seq_A2780_Human1.22036051
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21108612
64SMAD3_21741376_ChIP-Seq_ESCs_Human1.20903216
65ETV1_20927104_ChIP-Seq_GIST48_Human1.20509065
66P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.20171416
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18907313
68E2F1_20622854_ChIP-Seq_HELA_Human1.18186867
69PHF8_20622853_ChIP-Seq_HELA_Human1.18068112
70* ELF1_20517297_ChIP-Seq_JURKAT_Human1.15993107
71* PHF8_20622854_ChIP-Seq_HELA_Human1.15805833
72* TP63_22573176_ChIP-Seq_HFKS_Human1.15660012
73BCOR_27268052_Chip-Seq_Bcells_Human1.14972003
74ZNF274_21170338_ChIP-Seq_K562_Hela1.14895089
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14876251
76NANOG_19829295_ChIP-Seq_ESCs_Human1.14754470
77SOX2_19829295_ChIP-Seq_ESCs_Human1.14754470
78LXR_22292898_ChIP-Seq_THP-1_Human1.12653821
79TAF2_19829295_ChIP-Seq_ESCs_Human1.11319821
80GATA3_21878914_ChIP-Seq_MCF-7_Human1.11001310
81STAT3_23295773_ChIP-Seq_U87_Human1.10879241
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10780811
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10712813
84SPI1_20517297_ChIP-Seq_HL60_Human1.10110012
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.08683402
86TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06235804
87GATA6_21074721_ChIP-Seq_CACO-2_Human1.05741932
88PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04409344
89NFYA_21822215_ChIP-Seq_K562_Human1.03285705
90TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.03064134
91P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01872139
92HOXB7_26014856_ChIP-Seq_BT474_Human1.00884017
93CEBPB_22108803_ChIP-Seq_LS180_Human1.00356079
94GF1_26923725_Chip-Seq_HPCs_Mouse0.98777523
95GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.98171969
96FOXH1_21741376_ChIP-Seq_ESCs_Human0.98005816
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96996834
98PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.96742781
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96733472
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95656700

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.55165895
2MP0005377_hearing/vestibular/ear_phenot4.50910115
3MP0003878_abnormal_ear_physiology4.50910115
4MP0001929_abnormal_gametogenesis4.02991714
5MP0005670_abnormal_white_adipose3.36647142
6MP0008004_abnormal_stomach_pH3.19963140
7MP0003315_abnormal_perineum_morphology2.94345409
8MP0002132_abnormal_respiratory_system2.47351702
9MP0002161_abnormal_fertility/fecundity2.46580167
10MP0001348_abnormal_lacrimal_gland2.29749708
11MP0003718_maternal_effect2.09105310
12MP0002210_abnormal_sex_determination2.02110185
13MP0005410_abnormal_fertilization12.7401457
14MP0005360_urolithiasis1.92628719
15MP0000678_abnormal_parathyroid_gland1.71857993
16MP0001145_abnormal_male_reproductive1.70755952
17MP0002160_abnormal_reproductive_system1.61795727
18MP0001984_abnormal_olfaction1.61451299
19MP0005451_abnormal_body_composition1.61084960
20MP0001485_abnormal_pinna_reflex1.60608018
21MP0000653_abnormal_sex_gland1.58277981
22MP0003646_muscle_fatigue1.39431583
23MP0003879_abnormal_hair_cell1.34916052
24MP0001905_abnormal_dopamine_level1.34686116
25MP0003045_fibrosis1.32003631
26MP0001486_abnormal_startle_reflex1.29959518
27MP0002822_catalepsy1.29832002
28MP0005647_abnormal_sex_gland1.28521243
29MP0005379_endocrine/exocrine_gland_phen1.22713118
30MP0009697_abnormal_copulation1.21373072
31MP0008995_early_reproductive_senescence1.20807719
32MP0005395_other_phenotype1.17837454
33MP0002249_abnormal_larynx_morphology1.15342734
34MP0002282_abnormal_trachea_morphology1.12535238
35MP0002127_abnormal_cardiovascular_syste1.09777977
36MP0005248_abnormal_Harderian_gland1.07324174
37MP0004859_abnormal_synaptic_plasticity1.06822859
38MP0010386_abnormal_urinary_bladder1.05821752
39MP0001963_abnormal_hearing_physiology0.99579209
40MP0004742_abnormal_vestibular_system0.96294168
41MP0002138_abnormal_hepatobiliary_system0.96238517
42MP0005499_abnormal_olfactory_system0.96150267
43MP0005394_taste/olfaction_phenotype0.96150267
44MP0005253_abnormal_eye_physiology0.94254149
45MP0005423_abnormal_somatic_nervous0.93691427
46MP0004085_abnormal_heartbeat0.87162100
47MP0003136_yellow_coat_color0.86758193
48MP0000026_abnormal_inner_ear0.85675735
49MP0001664_abnormal_digestion0.84671243
50MP0001968_abnormal_touch/_nociception0.83966099
51MP0010368_abnormal_lymphatic_system0.80999853
52MP0005551_abnormal_eye_electrophysiolog0.80093292
53MP0000534_abnormal_ureter_morphology0.79466107
54MP0004084_abnormal_cardiac_muscle0.76899547
55MP0005310_abnormal_salivary_gland0.75585070
56MP0001765_abnormal_ion_homeostasis0.75302052
57MP0009115_abnormal_fat_cell0.73571024
58MP0001501_abnormal_sleep_pattern0.73311922
59MP0000538_abnormal_urinary_bladder0.73052653
60MP0005389_reproductive_system_phenotype0.70571381
61MP0003632_abnormal_nervous_system0.69340061
62MP0003631_nervous_system_phenotype0.67843455
63MP0003936_abnormal_reproductive_system0.67533384
64MP0004036_abnormal_muscle_relaxation0.66345046
65MP0005167_abnormal_blood-brain_barrier0.66072255
66MP0002735_abnormal_chemical_nociception0.65352656
67MP0002067_abnormal_sensory_capabilities0.63489955
68MP0002229_neurodegeneration0.63246672
69MP0000230_abnormal_systemic_arterial0.63159775
70MP0008877_abnormal_DNA_methylation0.59349251
71MP0000470_abnormal_stomach_morphology0.58993388
72MP0002168_other_aberrant_phenotype0.58717927
73MP0000955_abnormal_spinal_cord0.58505348
74MP0003011_delayed_dark_adaptation0.57475715
75MP0001188_hyperpigmentation0.56075522
76MP0009053_abnormal_anal_canal0.55765538
77MP0002272_abnormal_nervous_system0.54101288
78MP0000049_abnormal_middle_ear0.51880071
79MP0003633_abnormal_nervous_system0.51684079
80MP0002557_abnormal_social/conspecific_i0.51228962
81MP0002572_abnormal_emotion/affect_behav0.49828288
82MP0000681_abnormal_thyroid_gland0.49377145
83MP0006072_abnormal_retinal_apoptosis0.49356173
84MP0002234_abnormal_pharynx_morphology0.47969170
85MP0005595_abnormal_vascular_smooth0.47857193
86MP0004484_altered_response_of0.45981934
87MP0005058_abnormal_lysosome_morphology0.45864374
88MP0004782_abnormal_surfactant_physiolog0.45377299
89MP0001270_distended_abdomen0.45100699
90MP0005391_vision/eye_phenotype0.43640454
91MP0003635_abnormal_synaptic_transmissio0.41458675
92MP0009745_abnormal_behavioral_response0.40886805
93MP0005623_abnormal_meninges_morphology0.40326811
94MP0008789_abnormal_olfactory_epithelium0.40153876
95MP0004510_myositis0.39985494
96MP0001545_abnormal_hematopoietic_system0.39313665
97MP0005397_hematopoietic_system_phenotyp0.39313665
98MP0008569_lethality_at_weaning0.38644192
99MP0001666_abnormal_nutrient_absorption0.37545990
100MP0005646_abnormal_pituitary_gland0.36167504

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)7.18897800
2Absent/shortened dynein arms (HP:0200106)7.18897800
3Resting tremor (HP:0002322)6.97634119
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.17792950
5Abnormal respiratory motile cilium physiology (HP:0012261)5.96759204
6Abnormal ciliary motility (HP:0012262)5.89299615
7Tubulointerstitial nephritis (HP:0001970)5.40604333
8Severe visual impairment (HP:0001141)5.33794972
9Abnormal respiratory motile cilium morphology (HP:0005938)5.11186466
10Abnormal respiratory epithelium morphology (HP:0012253)5.11186466
11Infertility (HP:0000789)5.07483050
12Chronic hepatic failure (HP:0100626)4.86674658
13Postural instability (HP:0002172)4.66134071
14Asymmetric septal hypertrophy (HP:0001670)4.65676208
15Nasal polyposis (HP:0100582)4.53943180
16Abnormal sex determination (HP:0012244)4.21150614
17Sex reversal (HP:0012245)4.21150614
18Bony spicule pigmentary retinopathy (HP:0007737)3.93801705
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.93671064
20Male infertility (HP:0003251)3.89325013
21Attenuation of retinal blood vessels (HP:0007843)3.82488820
22Abnormality of the nasal mucosa (HP:0000433)3.80651479
23Abnormality of macular pigmentation (HP:0008002)3.77945310
24Rhinitis (HP:0012384)3.45984151
25Hypoplasia of the uterus (HP:0000013)3.40201152
26Aplasia/Hypoplasia of the earlobes (HP:0009906)3.23450767
27Hyperkalemia (HP:0002153)3.22048215
28Cone-rod dystrophy (HP:0000548)3.19660960
29Impulsivity (HP:0100710)3.16582432
30Bell-shaped thorax (HP:0001591)3.13324000
31Abnormality of dental color (HP:0011073)2.94780629
32Gonadal dysgenesis (HP:0000133)2.92908457
33Abnormal rod and cone electroretinograms (HP:0008323)2.88666356
34Chronic bronchitis (HP:0004469)2.83607891
35Cerebellar dysplasia (HP:0007033)2.83459589
36Hypoplasia of the thymus (HP:0000778)2.78795991
37Facial shape deformation (HP:0011334)2.77014836
38Potter facies (HP:0002009)2.77014836
39Hypoalphalipoproteinemia (HP:0003233)2.75515138
40Colitis (HP:0002583)2.66417436
41Male pseudohermaphroditism (HP:0000037)2.59431393
42Abnormality of the columella (HP:0009929)2.55015679
43Bronchiectasis (HP:0002110)2.53058358
44Aplasia/hypoplasia of the uterus (HP:0008684)2.52407521
45Menstrual irregularities (HP:0000858)2.51803408
46Congenital sensorineural hearing impairment (HP:0008527)2.49672636
47Polydipsia (HP:0001959)2.48307967
48Abnormal drinking behavior (HP:0030082)2.48307967
49Occipital encephalocele (HP:0002085)2.47372468
50Progressive sensorineural hearing impairment (HP:0000408)2.41569094
51Type II lissencephaly (HP:0007260)2.40014055
52Tubulointerstitial abnormality (HP:0001969)2.39882820
53Hypoplastic ischia (HP:0003175)2.38758491
54Renovascular hypertension (HP:0100817)2.38422115
55Progressive cerebellar ataxia (HP:0002073)2.37385676
56Abnormal urine output (HP:0012590)2.37344755
57Portal hypertension (HP:0001409)2.37086441
58Abnormal spermatogenesis (HP:0008669)2.32608413
59Germ cell neoplasia (HP:0100728)2.31721137
60Amelogenesis imperfecta (HP:0000705)2.28674404
61Abnormality of the hepatic vasculature (HP:0006707)2.26392657
62Truncal obesity (HP:0001956)2.26090299
63Enlarged epiphyses (HP:0010580)2.22595780
64Renal dysplasia (HP:0000110)2.21008575
65Abnormality of the ischium (HP:0003174)2.20901935
66Reduced antithrombin III activity (HP:0001976)2.17605962
67Atonic seizures (HP:0010819)2.16973893
68Nephronophthisis (HP:0000090)2.15508553
69Sensory axonal neuropathy (HP:0003390)2.14229430
70Anterior segment dysgenesis (HP:0007700)2.12910334
71Stage 5 chronic kidney disease (HP:0003774)2.12648619
72Insulin-resistant diabetes mellitus (HP:0000831)2.11728766
73Retinal dysplasia (HP:0007973)2.09087316
74Optic nerve hypoplasia (HP:0000609)2.08168713
75Flattened epiphyses (HP:0003071)2.06948872
76Azoospermia (HP:0000027)2.06047353
77Abnormality of renal excretion (HP:0011036)2.02657404
78Polyuria (HP:0000103)1.99949286
79Retinal atrophy (HP:0001105)1.98684867
80Generalized aminoaciduria (HP:0002909)1.95093265
81Abnormality of the costochondral junction (HP:0000919)1.94579439
82Ventricular fibrillation (HP:0001663)1.94407237
83Hyperuricemia (HP:0002149)1.93467875
84Increased purine levels (HP:0004368)1.93467875
85Thoracolumbar scoliosis (HP:0002944)1.93393698
86Recurrent corneal erosions (HP:0000495)1.88915413
87Self-mutilation (HP:0000742)1.81797465
88Abnormality of potassium homeostasis (HP:0011042)1.80369965
89Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80194850
90Photophobia (HP:0000613)1.79546019
91Abnormality of the renal medulla (HP:0100957)1.78459625
92Widely patent fontanelles and sutures (HP:0004492)1.73429017
93Hypophosphatemic rickets (HP:0004912)1.70164521
94Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66123953
95Inflammation of the large intestine (HP:0002037)1.65269929
96Epiphyseal dysplasia (HP:0002656)1.62175180
97Atrial fibrillation (HP:0005110)1.62145613
98Intellectual disability, moderate (HP:0002342)1.61941506
99Type II diabetes mellitus (HP:0005978)1.61668321
100Bradykinesia (HP:0002067)1.60784757

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.48464852
2PINK17.44103273
3MARK33.76995422
4INSRR3.35337030
5TESK13.25933655
6STK382.90665276
7DDR22.82786153
8BRD42.76772527
9PLK22.65690345
10STK38L2.36394877
11ZAK2.23346712
12PNCK2.19951470
13TLK12.18911187
14MAPK152.02709549
15MYLK1.86013379
16MST1R1.85468470
17LATS11.85045503
18CAMK1G1.83337293
19RPS6KA51.64715009
20PIK3CG1.63703520
21PRKD31.62705744
22NEK21.46910542
23MAP4K21.44514827
24PDPK11.32753735
25PDK11.24477126
26PTK2B1.10361825
27LATS21.09892635
28CDK121.09227077
29TYRO31.05866438
30CDK31.04910037
31WNK10.97025378
32MAP3K90.96308153
33NEK60.91489184
34SGK4940.90333420
35SGK2230.90333420
36PRKG20.90212305
37MAP2K70.80493236
38TIE10.72943591
39CDK70.71875390
40BMPR1B0.69084068
41PRKG10.65663266
42AKT30.64966575
43CAMK1D0.64846567
44DYRK1B0.62130262
45ARAF0.61983937
46CAMK10.61914961
47FRK0.59307085
48BRAF0.57929571
49ROCK10.56709321
50MAP3K10.55157431
51KSR20.53273484
52PRKCQ0.51081218
53DYRK30.50753900
54RPS6KA10.48238561
55VRK10.45051385
56SIK20.43736671
57RPS6KA20.42447266
58PKN10.40701347
59OBSCN0.38489352
60CDK140.37694155
61MAPK10.37500064
62MTOR0.33744798
63PAK10.30185180
64PAK20.29092468
65GSK3B0.28122935
66PRKAA20.27498158
67FGFR20.25792375
68CDK10.23916216
69SGK20.23753675
70MAP3K130.23212730
71JAK30.23013868
72CDK20.22195674
73MAP3K110.20653773
74CDK50.20265030
75MET0.20104634
76DYRK20.19680648
77MAP3K20.18615288
78MAP3K80.18432783
79CDC42BPA0.18108907
80CAMK40.17621695
81ADRBK20.17380258
82STK390.16555891
83MUSK0.15910215
84SGK10.15419488
85ATM0.15215049
86CSNK1A10.13622409
87PRKCB0.13184074
88CSNK1A1L0.12918365
89RPS6KA30.12583595
90RPS6KL10.12348360
91RPS6KC10.12348360
92MAPK80.11863408
93CHEK10.10857548
94WNK40.08886227
95CSNK1G30.08875435
96RPS6KA60.08455086
97AKT10.08353956
98MOS0.07813374
99ICK0.07503185
100MAP2K20.06939169

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.12399780
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051304.52422676
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.26922952
4Olfactory transduction_Homo sapiens_hsa047404.04229661
5Gap junction_Homo sapiens_hsa045403.41994185
6Hedgehog signaling pathway_Homo sapiens_hsa043402.64019506
7Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.47324040
8Nitrogen metabolism_Homo sapiens_hsa009102.45634043
9Butanoate metabolism_Homo sapiens_hsa006502.30656442
10Arginine biosynthesis_Homo sapiens_hsa002202.25872516
11Dorso-ventral axis formation_Homo sapiens_hsa043201.98565045
12Systemic lupus erythematosus_Homo sapiens_hsa053221.88211792
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.72041766
14Glycerophospholipid metabolism_Homo sapiens_hsa005641.71734703
15Phagosome_Homo sapiens_hsa041451.67409018
16Taste transduction_Homo sapiens_hsa047421.64041539
17Phenylalanine metabolism_Homo sapiens_hsa003601.56825250
18Apoptosis_Homo sapiens_hsa042101.56329688
19Alcoholism_Homo sapiens_hsa050341.52691398
20Fatty acid degradation_Homo sapiens_hsa000711.50141721
21Propanoate metabolism_Homo sapiens_hsa006401.43776306
22RNA transport_Homo sapiens_hsa030131.39424054
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.20565780
24PPAR signaling pathway_Homo sapiens_hsa033201.13741866
25Fatty acid metabolism_Homo sapiens_hsa012121.12595516
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07979996
27Oocyte meiosis_Homo sapiens_hsa041141.06762749
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99842798
29Steroid hormone biosynthesis_Homo sapiens_hsa001400.94533956
30Type II diabetes mellitus_Homo sapiens_hsa049300.92751694
31Renin secretion_Homo sapiens_hsa049240.90797580
32Synaptic vesicle cycle_Homo sapiens_hsa047210.90312546
33Vascular smooth muscle contraction_Homo sapiens_hsa042700.89379241
34Calcium signaling pathway_Homo sapiens_hsa040200.88599528
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85681439
36Protein digestion and absorption_Homo sapiens_hsa049740.79829645
37cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77737853
38Gastric acid secretion_Homo sapiens_hsa049710.76819410
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74874712
40Adipocytokine signaling pathway_Homo sapiens_hsa049200.73488309
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72946334
42Tyrosine metabolism_Homo sapiens_hsa003500.71750850
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70996760
44Phototransduction_Homo sapiens_hsa047440.70605158
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70544449
46Salivary secretion_Homo sapiens_hsa049700.66407694
47Circadian entrainment_Homo sapiens_hsa047130.65958239
48Pyruvate metabolism_Homo sapiens_hsa006200.65280207
49Inositol phosphate metabolism_Homo sapiens_hsa005620.64042685
50Oxytocin signaling pathway_Homo sapiens_hsa049210.62519375
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61317368
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60835287
53Chemical carcinogenesis_Homo sapiens_hsa052040.58770996
54ABC transporters_Homo sapiens_hsa020100.58684226
55cAMP signaling pathway_Homo sapiens_hsa040240.58646305
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58136180
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57756791
58ECM-receptor interaction_Homo sapiens_hsa045120.57431548
59mRNA surveillance pathway_Homo sapiens_hsa030150.57327263
60Purine metabolism_Homo sapiens_hsa002300.56755122
61Glucagon signaling pathway_Homo sapiens_hsa049220.56722207
62Arginine and proline metabolism_Homo sapiens_hsa003300.55445175
63Glycerolipid metabolism_Homo sapiens_hsa005610.54418535
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54004086
65Type I diabetes mellitus_Homo sapiens_hsa049400.53250397
66Glutathione metabolism_Homo sapiens_hsa004800.52967666
67Fanconi anemia pathway_Homo sapiens_hsa034600.51826618
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51351346
69Estrogen signaling pathway_Homo sapiens_hsa049150.51328975
70Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49604699
71Basal transcription factors_Homo sapiens_hsa030220.49009679
72Nicotine addiction_Homo sapiens_hsa050330.47578679
73Endocytosis_Homo sapiens_hsa041440.47460658
74Morphine addiction_Homo sapiens_hsa050320.46422846
75Glutamatergic synapse_Homo sapiens_hsa047240.45903620
76Influenza A_Homo sapiens_hsa051640.45238570
77VEGF signaling pathway_Homo sapiens_hsa043700.42421559
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42222739
79Long-term potentiation_Homo sapiens_hsa047200.42031316
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41906365
81Retinol metabolism_Homo sapiens_hsa008300.41269477
82Selenocompound metabolism_Homo sapiens_hsa004500.39867518
83Antigen processing and presentation_Homo sapiens_hsa046120.38914273
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38858921
85Tryptophan metabolism_Homo sapiens_hsa003800.38282324
86Allograft rejection_Homo sapiens_hsa053300.37429882
87Autoimmune thyroid disease_Homo sapiens_hsa053200.36363726
88Fat digestion and absorption_Homo sapiens_hsa049750.36283732
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36104520
90MAPK signaling pathway_Homo sapiens_hsa040100.35953750
91Bile secretion_Homo sapiens_hsa049760.33239937
92Graft-versus-host disease_Homo sapiens_hsa053320.30577379
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30495094
94Cardiac muscle contraction_Homo sapiens_hsa042600.28933034
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.24896804
96Cholinergic synapse_Homo sapiens_hsa047250.24519145
97Tight junction_Homo sapiens_hsa045300.24048407
98Amphetamine addiction_Homo sapiens_hsa050310.23871430
99GABAergic synapse_Homo sapiens_hsa047270.23833008
100Biosynthesis of amino acids_Homo sapiens_hsa012300.22884210

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