ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm capacitation (GO:0048240)	9.36738688
2	indole-containing compound catabolic process (GO:0042436)	9.02768124
3	indolalkylamine catabolic process (GO:0046218)	9.02768124
4	tryptophan catabolic process (GO:0006569)	9.02768124
5	regulation of tolerance induction (GO:0002643)	8.74463934
6	tryptophan metabolic process (GO:0006568)	7.89517711
7	regulation of chronic inflammatory response (GO:0002676)	7.42665405
8	single fertilization (GO:0007338)	7.14468122
9	heterotypic cell-cell adhesion (GO:0034113)	6.93967625
10	aromatic amino acid family catabolic process (GO:0009074)	6.88651094
11	positive regulation of type 2 immune response (GO:0002830)	6.09307840
12	negative regulation of interleukin-10 production (GO:0032693)	5.97323814
13	amine catabolic process (GO:0009310)	5.92469214
14	cellular biogenic amine catabolic process (GO:0042402)	5.92469214
15	indolalkylamine metabolic process (GO:0006586)	5.82325724
16	benzene-containing compound metabolic process (GO:0042537)	5.21190293
17	aromatic amino acid family metabolic process (GO:0009072)	5.00215798
18	fertilization (GO:0009566)	4.68256025
19	sulfur amino acid catabolic process (GO:0000098)	4.49490937
20	reverse cholesterol transport (GO:0043691)	4.27031553
21	negative regulation of interleukin-8 production (GO:0032717)	4.19793292
22	alpha-linolenic acid metabolic process (GO:0036109)	4.18405376
23	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.16926650
24	indole-containing compound metabolic process (GO:0042430)	4.08103878
25	L-phenylalanine catabolic process (GO:0006559)	3.95754590
26	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.95754590
27	digestion (GO:0007586)	3.91980783
28	complement activation, alternative pathway (GO:0006957)	3.88480404
29	negative regulation of endopeptidase activity (GO:0010951)	3.85964021
30	cysteine metabolic process (GO:0006534)	3.84155194
31	negative regulation of T cell apoptotic process (GO:0070233)	3.72705600
32	negative regulation of peptidase activity (GO:0010466)	3.68457562
33	phospholipid homeostasis (GO:0055091)	3.66911559
34	positive regulation of cell-cell adhesion (GO:0022409)	3.65118819
35	L-phenylalanine metabolic process (GO:0006558)	3.64910243
36	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.64910243
37	transepithelial transport (GO:0070633)	3.59940372
38	epithelial cell morphogenesis (GO:0003382)	3.59725912
39	high-density lipoprotein particle remodeling (GO:0034375)	3.59404331
40	alpha-amino acid catabolic process (GO:1901606)	3.33415291
41	cellular amino acid catabolic process (GO:0009063)	3.17094726
42	regulation of type 2 immune response (GO:0002828)	3.13903066
43	N-acetylneuraminate metabolic process (GO:0006054)	3.02751904
44	negative regulation of protein autophosphorylation (GO:0031953)	3.02239310
45	seminiferous tubule development (GO:0072520)	20.7778898
46	valine metabolic process (GO:0006573)	2.98977856
47	regulation of lipoprotein metabolic process (GO:0050746)	2.98749134
48	protein-lipid complex remodeling (GO:0034368)	2.97107992
49	macromolecular complex remodeling (GO:0034367)	2.97107992
50	plasma lipoprotein particle remodeling (GO:0034369)	2.97107992
51	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.95829412
52	defense response to bacterium (GO:0042742)	2.95803927
53	regulation of clathrin-mediated endocytosis (GO:2000369)	2.95563899
54	regulation of protein activation cascade (GO:2000257)	2.91292782
55	glutamate metabolic process (GO:0006536)	2.90405540
56	ethanol oxidation (GO:0006069)	2.87236416
57	regulation of complement activation (GO:0030449)	2.85237652
58	cellular modified amino acid catabolic process (GO:0042219)	2.84292091
59	bile acid biosynthetic process (GO:0006699)	2.76325102
60	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	2.72157915
61	hormone catabolic process (GO:0042447)	2.70244811
62	negative regulation of fibrinolysis (GO:0051918)	2.63862866
63	dicarboxylic acid biosynthetic process (GO:0043650)	2.63730066
64	regulation of macrophage activation (GO:0043030)	2.63604309
65	glyoxylate metabolic process (GO:0046487)	2.62492839
66	carboxylic acid catabolic process (GO:0046395)	2.61615975
67	organic acid catabolic process (GO:0016054)	2.61615975
68	regulation of triglyceride catabolic process (GO:0010896)	2.59401292
69	response to bacterium (GO:0009617)	2.56567455
70	low-density lipoprotein particle clearance (GO:0034383)	2.55747474
71	lysine metabolic process (GO:0006553)	2.54680315
72	lysine catabolic process (GO:0006554)	2.54680315
73	fatty acid beta-oxidation (GO:0006635)	2.54396512
74	serine family amino acid catabolic process (GO:0009071)	2.53621079
75	complement activation, classical pathway (GO:0006958)	2.52559059
76	2-oxoglutarate metabolic process (GO:0006103)	2.50526510
77	aspartate family amino acid catabolic process (GO:0009068)	2.49951730
78	plasma lipoprotein particle clearance (GO:0034381)	2.49496780
79	negative regulation of proteolysis (GO:0045861)	2.46487864
80	complement activation (GO:0006956)	2.46094545
81	triglyceride catabolic process (GO:0019433)	2.44872816
82	acylglycerol catabolic process (GO:0046464)	2.43188681
83	neutral lipid catabolic process (GO:0046461)	2.43188681
84	cytolysis (GO:0019835)	2.40779488
85	regulation of fibrinolysis (GO:0051917)	2.39325836
86	negative regulation of protein processing (GO:0010955)	2.38970656
87	negative regulation of protein maturation (GO:1903318)	2.38970656
88	protein carboxylation (GO:0018214)	2.38916482
89	peptidyl-glutamic acid carboxylation (GO:0017187)	2.38916482
90	urea metabolic process (GO:0019627)	2.38614622
91	urea cycle (GO:0000050)	2.38614622
92	sialylation (GO:0097503)	2.37906918
93	fatty acid oxidation (GO:0019395)	2.37761518
94	negative regulation of lipase activity (GO:0060192)	2.37609543
95	fatty acid catabolic process (GO:0009062)	2.37576700
96	lipid catabolic process (GO:0016042)	2.37504012
97	production of molecular mediator involved in inflammatory response (GO:0002532)	11.9926842
98	regulation of T cell tolerance induction (GO:0002664)	11.7864837
99	kynurenine metabolic process (GO:0070189)	10.6025339
100	positive regulation of tolerance induction (GO:0002645)	10.0758492

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	5.03846819
2	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	4.09191641
3	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.01349762
4	* RXR_22158963_ChIP-Seq_LIVER_Mouse	3.80034035
5	PPARA_22158963_ChIP-Seq_LIVER_Mouse	3.40741177
6	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.36751454
7	* LXR_22158963_ChIP-Seq_LIVER_Mouse	3.30249465
8	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.21701805
9	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.98277647
10	AR_21572438_ChIP-Seq_LNCaP_Human	2.91746952
11	ZNF263_19887448_ChIP-Seq_K562_Human	2.40705388
12	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.35497181
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.33287665
14	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.07886057
15	CLOCK_20551151_ChIP-Seq_293T_Human	2.02716355
16	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.01716383
17	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.97169999
18	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.96474839
19	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.89801489
20	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.86441876
21	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.80883779
22	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.64168732
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.61884286
24	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.60861224
25	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.58129666
26	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.58060063
27	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.54997842
28	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.50874643
29	SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.48184757
30	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.47455484
31	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.46079237
32	STAT1_17558387_ChIP-Seq_HELA_Human	1.44528761
33	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.43436724
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.42307148
35	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.37551420
36	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.37258052
37	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.34777955
38	FLI1_21867929_ChIP-Seq_CD8_Mouse	1.34415591
39	REST_19997604_ChIP-ChIP_NEURONS_Mouse	1.33532330
40	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.30927163
41	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.28185519
42	ESRRB_18555785_Chip-Seq_ESCs_Mouse	1.24278019
43	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.21929853
44	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.21929853
45	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.19454849
46	HTT_18923047_ChIP-ChIP_STHdh_Human	1.13992584
47	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.13845992
48	* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.13694182
49	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.12838787
50	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12623828
51	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11322217
52	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.09687620
53	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.09396918
54	P68_20966046_ChIP-Seq_HELA_Human	1.09207995
55	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.07830837
56	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.06700162
57	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	1.04265876
58	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.03680527
59	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.03459445
60	MYC_19915707_ChIP-ChIP_AK7_Human	1.02513302
61	RACK7_27058665_Chip-Seq_MCF-7_Human	1.02258986
62	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.01084502
63	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.99936777
64	SMC4_20622854_ChIP-Seq_HELA_Human	0.99311792
65	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.95904390
66	VDR_24787735_ChIP-Seq_THP-1_Human	0.95511403
67	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.94851148
68	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.94279335
69	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.94166444
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93686500
71	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.92525811
72	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.91944172
73	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.91830217
74	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.90458188
75	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.89930454
76	BCL6_27268052_Chip-Seq_Bcells_Human	0.89384925
77	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.88797430
78	* MYC_27129775_Chip-Seq_CORNEA_Mouse	0.86786304
79	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.86625962
80	KDM2B_26808549_Chip-Seq_REH_Human	0.85704893
81	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.85448210
82	ETS1_21867929_ChIP-Seq_TH2_Mouse	0.85195539
83	LXR_22292898_ChIP-Seq_THP-1_Human	0.84888090
84	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.84504343
85	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.84339818
86	OCT4_20526341_ChIP-Seq_ESCs_Human	0.84123178
87	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.83732316
88	RAC3_21632823_ChIP-Seq_H3396_Human	0.82847905
89	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.82111407
90	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.81542054
91	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.81291499
92	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.81241404
93	BCOR_27268052_Chip-Seq_Bcells_Human	0.80293980
94	RUNX1_27457419_Chip-Seq_LIVER_Mouse	0.79276809
95	DROSHA_22980978_ChIP-Seq_HELA_Human	0.78953102
96	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.78776133
97	GATA1_19941826_ChIP-Seq_K562_Human	0.78731812
98	P300_27268052_Chip-Seq_Bcells_Human	0.78523996
99	NANOG_20526341_ChIP-Seq_ESCs_Human	0.78315780
100	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.77781643

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	6.20542335
2	MP0003195_calcinosis	4.90694295
3	MP0005360_urolithiasis	4.29024477
4	MP0003303_peritoneal_inflammation	4.12499684
5	MP0002254_reproductive_system_inflammat	3.96630695
6	MP0004043_abnormal_pH_regulation	3.67317526
7	MP0005365_abnormal_bile_salt	3.63669771
8	MP0005085_abnormal_gallbladder_physiolo	3.62239481
9	MP0010234_abnormal_vibrissa_follicle	2.92706225
10	MP0010329_abnormal_lipoprotein_level	2.86336303
11	MP0003806_abnormal_nucleotide_metabolis	2.58952389
12	MP0008875_abnormal_xenobiotic_pharmacok	2.48399145
13	MP0003329_amyloid_beta_deposits	2.45442120
14	MP0005058_abnormal_lysosome_morphology	2.38548665
15	MP0005410_abnormal_fertilization	2.35532159
16	MP0003252_abnormal_bile_duct	2.22851087
17	MP0004145_abnormal_muscle_electrophysio	2.10553805
18	MP0004130_abnormal_muscle_cell	2.06975960
19	MP0005083_abnormal_biliary_tract	2.06612115
20	MP0005332_abnormal_amino_acid	2.00225407
21	MP0000604_amyloidosis	1.81846015
22	MP0002837_dystrophic_cardiac_calcinosis	1.78642272
23	MP0002118_abnormal_lipid_homeostasis	1.73709252
24	MP0009840_abnormal_foam_cell	1.67458698
25	MP0003191_abnormal_cellular_cholesterol	1.59660842
26	MP0000003_abnormal_adipose_tissue	1.54196746
27	MP0002168_other_aberrant_phenotype	1.52178254
28	MP0005584_abnormal_enzyme/coenzyme_acti	1.51563520
29	MP0001666_abnormal_nutrient_absorption	1.41583173
30	MP0009643_abnormal_urine_homeostasis	1.41469615
31	MP0000747_muscle_weakness	1.41288002
32	MP0000609_abnormal_liver_physiology	1.38633929
33	MP0003705_abnormal_hypodermis_morpholog	1.30727757
34	MP0005375_adipose_tissue_phenotype	1.28336265
35	MP0005319_abnormal_enzyme/_coenzyme	1.28216410
36	MP0003690_abnormal_glial_cell	1.24599693
37	MP0004185_abnormal_adipocyte_glucose	1.22817018
38	MP0001765_abnormal_ion_homeostasis	1.22743842
39	MP0004885_abnormal_endolymph	1.22010758
40	MP0001853_heart_inflammation	1.21800305
41	MP0004036_abnormal_muscle_relaxation	1.20812414
42	MP0003300_gastrointestinal_ulcer	1.18298975
43	MP0005636_abnormal_mineral_homeostasis	1.11135424
44	MP0000751_myopathy	1.09374994
45	MP0001501_abnormal_sleep_pattern	1.08648623
46	MP0000749_muscle_degeneration	1.08599069
47	MP0005666_abnormal_adipose_tissue	1.06633482
48	MP0001756_abnormal_urination	1.04811187
49	MP0001440_abnormal_grooming_behavior	1.04014487
50	MP0002138_abnormal_hepatobiliary_system	1.01442051
51	MP0003566_abnormal_cell_adhesion	0.98673215
52	MP0002971_abnormal_brown_adipose	0.98055733
53	MP0003656_abnormal_erythrocyte_physiolo	0.94258858
54	MP0004019_abnormal_vitamin_homeostasis	0.93015090
55	MP0002796_impaired_skin_barrier	0.91992531
56	MP0005670_abnormal_white_adipose	0.90352228
57	MP0004270_analgesia	0.88988042
58	MP0002876_abnormal_thyroid_physiology	0.86041470
59	MP0005334_abnormal_fat_pad	0.83657752
60	MP0004087_abnormal_muscle_fiber	0.82606947
61	MP0000534_abnormal_ureter_morphology	0.80663252
62	MP0003075_altered_response_to	0.80421801
63	MP0002089_abnormal_postnatal_growth/wei	0.80246139
64	MP0002269_muscular_atrophy	0.79947267
65	MP0005535_abnormal_body_temperature	0.79833255
66	MP0001764_abnormal_homeostasis	0.79193011
67	MP0005620_abnormal_muscle_contractility	0.78761179
68	MP0002896_abnormal_bone_mineralization	0.78493570
69	MP0004858_abnormal_nervous_system	0.76085989
70	MP0005275_abnormal_skin_tensile	0.71653597
71	MP0004859_abnormal_synaptic_plasticity	0.70884891
72	MP0002078_abnormal_glucose_homeostasis	0.70759693
73	MP0003632_abnormal_nervous_system	0.70222600
74	MP0002136_abnormal_kidney_physiology	0.67946273
75	MP0000920_abnormal_myelination	0.66719951
76	MP0003868_abnormal_feces_composition	0.65763566
77	MP0005395_other_phenotype	0.63143822
78	MP0000759_abnormal_skeletal_muscle	0.62670315
79	MP0009780_abnormal_chondrocyte_physiolo	0.62002279
80	MP0009384_cardiac_valve_regurgitation	0.61943467
81	MP0003879_abnormal_hair_cell	0.59879878
82	MP0008438_abnormal_cutaneous_collagen	0.59269225
83	MP0003959_abnormal_lean_body	0.58221034
84	MP0003631_nervous_system_phenotype	0.57663898
85	MP0002909_abnormal_adrenal_gland	0.57004839
86	MP0009764_decreased_sensitivity_to	0.56933984
87	MP0009763_increased_sensitivity_to	0.56712667
88	MP0005166_decreased_susceptibility_to	0.56246616
89	MP0003633_abnormal_nervous_system	0.56232783
90	MP0000750_abnormal_muscle_regeneration	0.55958821
91	MP0000598_abnormal_liver_morphology	0.55707396
92	MP0003698_abnormal_male_reproductive	0.55518713
93	MP0009642_abnormal_blood_homeostasis	0.55469379
94	MP0006036_abnormal_mitochondrial_physio	0.54083915
95	MP0010678_abnormal_skin_adnexa	0.52356480
96	MP0005330_cardiomyopathy	0.52338364
97	MP0000537_abnormal_urethra_morphology	0.52259271
98	MP0000249_abnormal_blood_vessel	0.51956121
99	MP0005408_hypopigmentation	0.49321444
100	MP0003646_muscle_fatigue	0.47781115

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Complement deficiency (HP:0004431)	5.56609293
2	Myocardial infarction (HP:0001658)	4.88946709
3	Deep venous thrombosis (HP:0002625)	4.67639079
4	Xanthomatosis (HP:0000991)	4.48940455
5	Intrahepatic cholestasis (HP:0001406)	4.43372157
6	Hypophosphatemic rickets (HP:0004912)	4.28536566
7	Vascular calcification (HP:0004934)	4.23178927
8	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.18427427
9	Abnormality of complement system (HP:0005339)	3.98684132
10	Cardiovascular calcification (HP:0011915)	3.87847235
11	Malnutrition (HP:0004395)	3.71903274
12	Potter facies (HP:0002009)	3.68650284
13	Facial shape deformation (HP:0011334)	3.68650284
14	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.49056398
15	Ketosis (HP:0001946)	3.47961126
16	Hyperlipoproteinemia (HP:0010980)	3.43636611
17	Neurofibrillary tangles (HP:0002185)	3.38358033
18	Hyperglycinuria (HP:0003108)	3.32817017
19	Recurrent gram-negative bacterial infections (HP:0005420)	3.29811434
20	Cerebral inclusion bodies (HP:0100314)	3.23575093
21	Hyperglycinemia (HP:0002154)	3.16215224
22	Exercise-induced myalgia (HP:0003738)	3.15049257
23	Gout (HP:0001997)	3.14973015
24	Ketoacidosis (HP:0001993)	3.13526626
25	Hypoalphalipoproteinemia (HP:0003233)	3.11871642
26	Abnormality of serine family amino acid metabolism (HP:0010894)	3.11690054
27	Abnormality of glycine metabolism (HP:0010895)	3.11690054
28	Hyperammonemia (HP:0001987)	3.03482912
29	Exercise-induced muscle cramps (HP:0003710)	3.02355874
30	Difficulty running (HP:0009046)	3.01806663
31	Epidermoid cyst (HP:0200040)	3.00664658
32	Hypobetalipoproteinemia (HP:0003563)	2.96659196
33	Abnormality of purine metabolism (HP:0004352)	2.87687900
34	Rickets (HP:0002748)	2.87473512
35	Hypolipoproteinemia (HP:0010981)	2.85968663
36	Prolonged partial thromboplastin time (HP:0003645)	2.82861577
37	Muscle hypertrophy of the lower extremities (HP:0008968)	2.82161203
38	Hyporeflexia of lower limbs (HP:0002600)	2.75790451
39	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.72159100
40	Calf muscle hypertrophy (HP:0008981)	2.68284392
41	Myoglobinuria (HP:0002913)	2.66393686
42	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.63441544
43	Muscle fiber splitting (HP:0003555)	2.62173646
44	Infantile muscular hypotonia (HP:0008947)	2.61297704
45	Skin nodule (HP:0200036)	2.54958716
46	Choroideremia (HP:0001139)	2.53750719
47	Abnormality of the common coagulation pathway (HP:0010990)	2.43588086
48	Widely patent fontanelles and sutures (HP:0004492)	2.40613868
49	Choreoathetosis (HP:0001266)	2.40082178
50	Intention tremor (HP:0002080)	2.39535809
51	Hemorrhage of the eye (HP:0011885)	2.38529961
52	Hypoglycemic coma (HP:0001325)	2.36904770
53	Systemic lupus erythematosus (HP:0002725)	2.35643915
54	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.33527164
55	Neoplasm of the heart (HP:0100544)	2.30719882
56	Increased connective tissue (HP:0009025)	2.30586849
57	Spastic diplegia (HP:0001264)	2.23346549
58	Agitation (HP:0000713)	2.20191206
59	Hypercholesterolemia (HP:0003124)	2.16019031
60	Cholelithiasis (HP:0001081)	2.15790248
61	Abnormal gallbladder morphology (HP:0012437)	2.13771041
62	Abnormality of nucleobase metabolism (HP:0010932)	2.12483096
63	Supranuclear gaze palsy (HP:0000605)	2.11609547
64	Abnormality of the Achilles tendon (HP:0005109)	2.05378252
65	Polar cataract (HP:0010696)	2.04183951
66	Muscle stiffness (HP:0003552)	2.03960231
67	Fat malabsorption (HP:0002630)	2.03723834
68	EMG: myopathic abnormalities (HP:0003458)	2.02231104
69	Acanthosis nigricans (HP:0000956)	2.01644576
70	Abnormality of fatty-acid metabolism (HP:0004359)	1.99880220
71	Hypertriglyceridemia (HP:0002155)	1.97484261
72	Testicular atrophy (HP:0000029)	1.96199244
73	Neonatal onset (HP:0003623)	1.94864103
74	Increased purine levels (HP:0004368)	1.94689787
75	Hyperuricemia (HP:0002149)	1.94689787
76	Joint hemorrhage (HP:0005261)	1.93587877
77	Abnormality of the intrinsic pathway (HP:0010989)	1.93200124
78	Oligomenorrhea (HP:0000876)	1.93117772
79	Hemiplegia (HP:0002301)	1.90659585
80	Amyloidosis (HP:0011034)	1.90486350
81	Abnormality of transition element cation homeostasis (HP:0011030)	1.88142166
82	Pancreatitis (HP:0001733)	1.87912887
83	Muscle fiber inclusion bodies (HP:0100299)	1.87733343
84	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.86710926
85	Hyperbilirubinemia (HP:0002904)	1.86675140
86	Late onset (HP:0003584)	1.85638725
87	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	1.81739721
88	Delayed CNS myelination (HP:0002188)	1.80110693
89	Hepatocellular carcinoma (HP:0001402)	1.79214180
90	Spontaneous abortion (HP:0005268)	1.79158356
91	Abnormal gallbladder physiology (HP:0012438)	1.78842230
92	Cholecystitis (HP:0001082)	1.78842230
93	Asymmetric septal hypertrophy (HP:0001670)	1.76345475
94	Sensorimotor neuropathy (HP:0007141)	1.72885310
95	Myotonia (HP:0002486)	1.72590947
96	Increased variability in muscle fiber diameter (HP:0003557)	1.72457963
97	Focal segmental glomerulosclerosis (HP:0000097)	1.71483037
98	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.71445111
99	Right ventricular cardiomyopathy (HP:0011663)	1.71076596
100	Abnormal enzyme/coenzyme activity (HP:0012379)	1.70032626

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ERN1	3.74716920
2	SIK1	3.19023832
3	BCKDK	2.79326686
4	EPHB1	2.79236256
5	MST4	2.79181760
6	FGFR4	2.54547760
7	LMTK2	2.49539895
8	TTN	2.45259649
9	TRIB3	2.35019375
10	PKN2	2.24331003
11	TAOK3	2.19012783
12	FGFR2	2.14118890
13	PHKG1	2.09356938
14	PHKG2	2.09356938
15	LRRK2	1.89320851
16	MAP2K4	1.89065935
17	FER	1.80954272
18	PDGFRA	1.79215992
19	MAP3K7	1.58462363
20	PTK6	1.55371112
21	STK39	1.52820514
22	WNK4	1.35020090
23	PDK4	1.32846839
24	PDK3	1.32846839
25	OBSCN	1.22300977
26	TNK2	1.21241170
27	MAP3K2	1.19902911
28	RET	1.14009737
29	PRKD3	1.13091841
30	PAK3	1.09808018
31	EPHA2	1.07669050
32	PIK3CG	1.06641549
33	PTK2B	1.05281487
34	PTK2	1.00661616
35	NTRK1	0.98352879
36	KSR2	0.97325545
37	MYLK	0.96639413
38	TYRO3	0.95872825
39	DMPK	0.95008560
40	INSRR	0.93608852
41	INSR	0.91862114
42	PAK6	0.87575920
43	PRKCH	0.87152686
44	FGFR3	0.85137972
45	MAP3K6	0.83661644
46	NTRK3	0.81327938
47	FRK	0.80874028
48	JAK2	0.80312009
49	MAPK12	0.79993466
50	GSK3A	0.78601392
51	PRKCG	0.77598688
52	STK10	0.76132326
53	ERBB4	0.75747015
54	CDK19	0.72591554
55	CAMK1G	0.72266960
56	MAP2K1	0.71884695
57	EPHA4	0.71730686
58	DAPK2	0.70337684
59	ICK	0.70163048
60	LATS1	0.69166393
61	LATS2	0.67658467
62	PRKACG	0.66454864
63	RIPK4	0.66395323
64	PDK2	0.63932060
65	EPHB2	0.63585310
66	MST1R	0.62425329
67	PAK2	0.62099118
68	PINK1	0.60942873
69	PRKCZ	0.60091386
70	FLT3	0.59602503
71	PRKAA2	0.56896574
72	CDK5	0.56529030
73	ERBB2	0.56445368
74	NTRK2	0.55508069
75	NEK1	0.54049382
76	PRKD1	0.51366089
77	SIK2	0.50753448
78	FGFR1	0.50436571
79	SCYL2	0.49143562
80	MAP2K3	0.48769214
81	CDK6	0.48615746
82	MET	0.47360521
83	PDPK1	0.46769685
84	PRKCQ	0.46491140
85	CAMK2G	0.46062499
86	CSNK1E	0.45144636
87	STK38	0.45100991
88	MAPK4	0.44461690
89	JAK1	0.44074461
90	PDK1	0.43960071
91	SRC	0.43476524
92	RIPK1	0.43026023
93	MAP3K12	0.42409928
94	TESK1	0.41725438
95	EGFR	0.41666519
96	ABL2	0.41521795
97	PIK3CA	0.41309365
98	CAMK1D	0.40499912
99	ALK	0.40399281
100	CSK	0.40005532

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	5.00638913
2	Tryptophan metabolism_Homo sapiens_hsa00380	3.53837461
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.30043307
4	Glutathione metabolism_Homo sapiens_hsa00480	3.28736053
5	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.14867389
6	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.68180947
7	Arginine biosynthesis_Homo sapiens_hsa00220	2.48963014
8	Fatty acid degradation_Homo sapiens_hsa00071	2.45389677
9	Arachidonic acid metabolism_Homo sapiens_hsa00590	2.44487683
10	Thyroid hormone synthesis_Homo sapiens_hsa04918	2.28229291
11	African trypanosomiasis_Homo sapiens_hsa05143	2.27190926
12	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.24764289
13	Fatty acid metabolism_Homo sapiens_hsa01212	2.13718419
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.05541116
15	Sulfur metabolism_Homo sapiens_hsa00920	1.98022545
16	PPAR signaling pathway_Homo sapiens_hsa03320	1.91700359
17	Complement and coagulation cascades_Homo sapiens_hsa04610	1.81813164
18	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.81737696
19	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.78997871
20	Propanoate metabolism_Homo sapiens_hsa00640	1.72427015
21	Butanoate metabolism_Homo sapiens_hsa00650	1.61360808
22	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.53909042
23	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.53635113
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.51640984
25	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.31901587
26	beta-Alanine metabolism_Homo sapiens_hsa00410	1.31370282
27	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.28591180
28	Pyruvate metabolism_Homo sapiens_hsa00620	1.24609677
29	Bile secretion_Homo sapiens_hsa04976	1.24187719
30	Glycerolipid metabolism_Homo sapiens_hsa00561	1.21832277
31	Phenylalanine metabolism_Homo sapiens_hsa00360	1.16882537
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.16570455
33	Peroxisome_Homo sapiens_hsa04146	1.15571824
34	Histidine metabolism_Homo sapiens_hsa00340	1.14028723
35	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.13960965
36	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.09937163
37	Fatty acid elongation_Homo sapiens_hsa00062	1.04354470
38	Fat digestion and absorption_Homo sapiens_hsa04975	1.01472971
39	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.00462662
40	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.98762050
41	Carbon metabolism_Homo sapiens_hsa01200	0.97086778
42	Chemical carcinogenesis_Homo sapiens_hsa05204	0.97043055
43	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.94161327
44	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.92080315
45	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.90801821
46	Arginine and proline metabolism_Homo sapiens_hsa00330	0.90527149
47	Folate biosynthesis_Homo sapiens_hsa00790	0.86832433
48	Tyrosine metabolism_Homo sapiens_hsa00350	0.84415934
49	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.82238923
50	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.80911872
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.77723890
52	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.74661296
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71879340
54	Salivary secretion_Homo sapiens_hsa04970	0.70307911
55	Prion diseases_Homo sapiens_hsa05020	0.69642216
56	ABC transporters_Homo sapiens_hsa02010	0.69598977
57	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.69397963
58	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.67287089
59	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.65707106
60	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.65367656
61	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.61565286
62	Caffeine metabolism_Homo sapiens_hsa00232	0.59283958
63	Renin secretion_Homo sapiens_hsa04924	0.59158707
64	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.57851716
65	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.54688623
66	Gastric acid secretion_Homo sapiens_hsa04971	0.54609995
67	Lysosome_Homo sapiens_hsa04142	0.54376124
68	Retinol metabolism_Homo sapiens_hsa00830	0.51469567
69	Selenocompound metabolism_Homo sapiens_hsa00450	0.49970503
70	GABAergic synapse_Homo sapiens_hsa04727	0.48671837
71	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.48105258
72	Glucagon signaling pathway_Homo sapiens_hsa04922	0.46089405
73	Steroid biosynthesis_Homo sapiens_hsa00100	0.44739845
74	Insulin resistance_Homo sapiens_hsa04931	0.40332104
75	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.37250747
76	Estrogen signaling pathway_Homo sapiens_hsa04915	0.31073261
77	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.30073654
78	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.29515009
79	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.27293506
80	Long-term potentiation_Homo sapiens_hsa04720	0.27212938
81	AMPK signaling pathway_Homo sapiens_hsa04152	0.25918576
82	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.23640088
83	Circadian entrainment_Homo sapiens_hsa04713	0.23499751
84	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.22963139
85	Pentose phosphate pathway_Homo sapiens_hsa00030	0.22644093
86	Collecting duct acid secretion_Homo sapiens_hsa04966	0.22615003
87	Metabolic pathways_Homo sapiens_hsa01100	0.21035921
88	Lysine degradation_Homo sapiens_hsa00310	0.19985263
89	Insulin signaling pathway_Homo sapiens_hsa04910	0.19539200
90	Vibrio cholerae infection_Homo sapiens_hsa05110	0.17262450
91	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.14842985
92	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.13068518
93	Insulin secretion_Homo sapiens_hsa04911	0.13034571
94	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.11412020
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.11032045
96	Glutamatergic synapse_Homo sapiens_hsa04724	0.10727425
97	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.09408111
98	Amphetamine addiction_Homo sapiens_hsa05031	0.09091147
99	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.08379316
100	GnRH signaling pathway_Homo sapiens_hsa04912	0.08178737

RNASE13

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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