RNASE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein antimicrobial activity against viruses. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil mediated immunity (GO:0002446)7.43897687
2killing of cells in other organism involved in symbiotic interaction (GO:0051883)7.13010942
3disruption of cells of other organism involved in symbiotic interaction (GO:0051818)7.13010942
4cellular extravasation (GO:0045123)6.93055973
5negative regulation of growth of symbiont in host (GO:0044130)6.66774212
6negative regulation of growth of symbiont involved in interaction with host (GO:0044146)6.66774212
7modulation of growth of symbiont involved in interaction with host (GO:0044144)6.66774212
8regulation of growth of symbiont in host (GO:0044126)6.66774212
9response to peptidoglycan (GO:0032494)6.49545201
10innate immune response in mucosa (GO:0002227)6.30902496
11positive regulation of interleukin-8 biosynthetic process (GO:0045416)6.21883967
12defense response to fungus (GO:0050832)6.10341639
13neutrophil activation involved in immune response (GO:0002283)5.92301005
14myeloid leukocyte mediated immunity (GO:0002444)5.85734727
15disruption of cells of other organism (GO:0044364)5.63601355
16killing of cells of other organism (GO:0031640)5.63601355
17antibacterial humoral response (GO:0019731)5.53947546
18response to fungus (GO:0009620)5.46006676
19mucosal immune response (GO:0002385)5.18528206
20antimicrobial humoral response (GO:0019730)5.15407248
21cell wall macromolecule catabolic process (GO:0016998)5.11495661
22organ or tissue specific immune response (GO:0002251)5.02875702
23negative regulation of interleukin-8 production (GO:0032717)5.01598917
24positive regulation of gamma-delta T cell activation (GO:0046645)4.90559401
25regulation of interleukin-8 biosynthetic process (GO:0045414)4.88130578
26positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.77331088
27negative regulation of erythrocyte differentiation (GO:0045647)4.76325627
28positive regulation of B cell differentiation (GO:0045579)4.58535722
29neutrophil activation (GO:0042119)4.50823616
30detection of other organism (GO:0098543)4.47979795
31respiratory burst (GO:0045730)4.41227040
32detection of bacterium (GO:0016045)4.24065892
33cell wall macromolecule metabolic process (GO:0044036)4.19589932
34microglial cell activation (GO:0001774)4.17606562
35hydrogen peroxide catabolic process (GO:0042744)4.16666707
36negative regulation of phagocytosis (GO:0050765)4.14542428
37regulation of mast cell degranulation (GO:0043304)4.11348180
38response to muramyl dipeptide (GO:0032495)4.09593083
39regulation of myeloid leukocyte mediated immunity (GO:0002886)4.04169594
40granulocyte activation (GO:0036230)4.02252055
41reactive oxygen species biosynthetic process (GO:1903409)3.93128791
42regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.88265804
43defense response to Gram-positive bacterium (GO:0050830)3.81949588
44regulation of mast cell activation involved in immune response (GO:0033006)3.80983805
45regulation of leukocyte degranulation (GO:0043300)3.78116165
46positive regulation of mast cell activation involved in immune response (GO:0033008)3.72635502
47positive regulation of mast cell degranulation (GO:0043306)3.72635502
48hemoglobin metabolic process (GO:0020027)3.71286741
49macrophage differentiation (GO:0030225)3.61522057
50regulation of chemokine biosynthetic process (GO:0045073)3.59949423
51definitive hemopoiesis (GO:0060216)3.54957087
52positive regulation of mast cell activation (GO:0033005)3.49229152
53angiotensin maturation (GO:0002003)3.44773800
54regulation of B cell differentiation (GO:0045577)3.44334112
55oxygen transport (GO:0015671)3.42672308
56positive regulation of granulocyte differentiation (GO:0030854)3.42032014
57cell killing (GO:0001906)3.38019090
58myeloid cell activation involved in immune response (GO:0002275)3.36436875
59regulation of mast cell activation (GO:0033003)3.34292676
60regulation of regulated secretory pathway (GO:1903305)3.33370534
61leukocyte mediated cytotoxicity (GO:0001909)3.31942608
62macrophage activation (GO:0042116)3.30638742
63regulation of gamma-delta T cell activation (GO:0046643)3.29164627
64leukocyte degranulation (GO:0043299)3.28835750
65regulation of gamma-delta T cell differentiation (GO:0045586)3.21860159
66negative regulation of interleukin-6 production (GO:0032715)3.21361422
67defense response to bacterium (GO:0042742)3.21063787
68mannose metabolic process (GO:0006013)3.17608701
69detection of external biotic stimulus (GO:0098581)3.16833284
70leukocyte aggregation (GO:0070486)3.15506430
71immunoglobulin mediated immune response (GO:0016064)3.13119825
72imidazole-containing compound metabolic process (GO:0052803)3.12970343
73regulation of MHC class II biosynthetic process (GO:0045346)3.12504704
74positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.12260041
75macrophage activation involved in immune response (GO:0002281)3.10388452
76negative regulation of interleukin-12 production (GO:0032695)3.08845989
77B cell receptor signaling pathway (GO:0050853)3.03713072
78regulation of hypersensitivity (GO:0002883)3.03533286
79mature B cell differentiation involved in immune response (GO:0002313)3.03337605
80regulation of B cell receptor signaling pathway (GO:0050855)3.01929822
81modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.97795042
82positive regulation by organism of defense response of other organism involved in symbiotic interact2.97795042
83modulation by symbiont of host immune response (GO:0052553)2.97795042
84positive regulation by symbiont of host defense response (GO:0052509)2.97795042
85modulation by symbiont of host defense response (GO:0052031)2.97795042
86modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.97795042
87pinocytosis (GO:0006907)2.96269812
88detection of biotic stimulus (GO:0009595)2.96158286
89mast cell activation (GO:0045576)2.94163349
90response to protozoan (GO:0001562)2.91653538
91response to bacterium (GO:0009617)2.88231028
92negative regulation of T cell mediated immunity (GO:0002710)2.87265898
93regulation of tolerance induction (GO:0002643)2.87089009
94hydrogen peroxide metabolic process (GO:0042743)2.86950198
95negative regulation of B cell apoptotic process (GO:0002903)2.85252089
96superoxide anion generation (GO:0042554)2.84710777
97natural killer cell activation involved in immune response (GO:0002323)2.83894659
98positive regulation of regulated secretory pathway (GO:1903307)2.78877267
99defense response to protozoan (GO:0042832)2.75097028
100gas transport (GO:0015669)2.74449540

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human5.52400367
2VDR_24763502_ChIP-Seq_THP-1_Human4.57549963
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.19948857
4SCL_19346495_ChIP-Seq_HPC-7_Human4.14820475
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.82083424
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.78509933
7MYB_21317192_ChIP-Seq_ERMYB_Mouse3.63144495
8* SPI1_23547873_ChIP-Seq_NB4_Human3.24090894
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.95720727
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.89110847
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.64791806
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.62348244
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.49648574
14* MYB_26560356_Chip-Seq_TH2_Human2.48450281
15MYC_22102868_ChIP-Seq_BL_Human2.48199761
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.44117097
17E2F7_22180533_ChIP-Seq_HELA_Human2.43827936
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39564296
19BRD4_27068464_Chip-Seq_AML-cells_Mouse2.38043591
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.38014332
21RUNX1_22412390_ChIP-Seq_EML_Mouse2.22301849
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.21368753
23* UTX_26944678_Chip-Seq_JUKART_Human2.21183233
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.17629571
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16600683
26SPI1_23127762_ChIP-Seq_K562_Human2.15082441
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.12272453
28VDR_24787735_ChIP-Seq_THP-1_Human2.10982737
29MAF_26560356_Chip-Seq_TH1_Human2.09808187
30MYB_26560356_Chip-Seq_TH1_Human2.00432445
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.98719342
32TCF7_22412390_ChIP-Seq_EML_Mouse1.86323529
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84777548
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84379943
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83866649
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82030559
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.80913343
38GATA1_22025678_ChIP-Seq_K562_Human1.80056244
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76029095
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.75597367
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.71035097
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70034595
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.67532570
44GATA1_19941827_ChIP-Seq_MEL_Mouse1.67461181
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66589989
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66224098
47GATA1_22383799_ChIP-Seq_G1ME_Mouse1.65940205
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.65367045
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64902285
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62030351
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.61244074
52RUNX_20019798_ChIP-Seq_JUKART_Human1.60438351
53MAF_26560356_Chip-Seq_TH2_Human1.56383684
54GATA1_19941826_ChIP-Seq_K562_Human1.53892270
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53407337
56PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.50878966
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49950038
58* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46004232
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45657544
60FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.44280509
61KDM2B_26808549_Chip-Seq_DND41_Human1.42087754
62PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39767525
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38006760
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37707353
65* GATA3_27048872_Chip-Seq_THYMUS_Human1.34840783
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34242342
67Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.33898484
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33082714
69CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32382122
70PU_27001747_Chip-Seq_BMDM_Mouse1.23748204
71LXR_22292898_ChIP-Seq_THP-1_Human1.23014216
72GATA2_19941826_ChIP-Seq_K562_Human1.20959593
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19604977
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19266245
75NCOR1_26117541_ChIP-Seq_K562_Human1.17762533
76CIITA_25753668_ChIP-Seq_RAJI_Human1.17198752
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16583618
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16455538
79* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16227123
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15659470
81BCL6_27268052_Chip-Seq_Bcells_Human1.14428381
82* GATA3_26560356_Chip-Seq_TH2_Human1.14312955
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13622072
84CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13314110
85PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13247395
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12167116
87ELF1_20517297_ChIP-Seq_JURKAT_Human1.11403087
88BCOR_27268052_Chip-Seq_Bcells_Human1.11349645
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08976971
90SPI1_20517297_ChIP-Seq_HL60_Human1.07695460
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07272448
92CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06684433
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03118148
94ETS1_22383799_ChIP-Seq_G1ME_Mouse1.01883215
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.00628368
96VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99870652
97TFEB_21752829_ChIP-Seq_HELA_Human0.99864560
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98617173
99ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95662260
100P300_27268052_Chip-Seq_Bcells_Human0.95586293

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.52111231
2MP0003436_decreased_susceptibility_to3.60337327
3MP0002419_abnormal_innate_immunity3.38601632
4MP0003172_abnormal_lysosome_physiology3.38354926
5MP0001835_abnormal_antigen_presentation3.38081139
6MP0005025_abnormal_response_to3.07646526
7MP0005464_abnormal_platelet_physiology2.86430031
8MP0009278_abnormal_bone_marrow2.79529691
9MP0002396_abnormal_hematopoietic_system2.77844606
10MP0005058_abnormal_lysosome_morphology2.71960316
11MP0001545_abnormal_hematopoietic_system2.65262396
12MP0005397_hematopoietic_system_phenotyp2.65262396
13MP0003656_abnormal_erythrocyte_physiolo2.61287570
14MP0009785_altered_susceptibility_to2.37724029
15MP0002420_abnormal_adaptive_immunity2.32107290
16MP0003724_increased_susceptibility_to2.31570764
17MP0001819_abnormal_immune_cell2.28053350
18MP0005000_abnormal_immune_tolerance2.20109930
19MP0002148_abnormal_hypersensitivity_rea2.19085607
20MP0000569_abnormal_digit_pigmentation2.17475072
21MP0001800_abnormal_humoral_immune2.17086611
22MP0002452_abnormal_antigen_presenting2.06577580
23MP0006082_CNS_inflammation2.04877155
24MP0002398_abnormal_bone_marrow2.04018813
25MP0002723_abnormal_immune_serum2.00254983
26MP0002009_preneoplasia1.97433737
27MP0002166_altered_tumor_susceptibility1.94963134
28MP0004808_abnormal_hematopoietic_stem1.88663591
29MP0000015_abnormal_ear_pigmentation1.86353823
30MP0000716_abnormal_immune_system1.83276541
31MP0000685_abnormal_immune_system1.82536161
32MP0004147_increased_porphyrin_level1.81836573
33MP0003828_pulmonary_edema1.81689096
34MP0002722_abnormal_immune_system1.75398134
35MP0003763_abnormal_thymus_physiology1.75395746
36MP0001533_abnormal_skeleton_physiology1.72138653
37MP0002405_respiratory_system_inflammati1.69460935
38MP0001853_heart_inflammation1.65815644
39MP0005671_abnormal_response_to1.65320091
40MP0005075_abnormal_melanosome_morpholog1.64545979
41MP0005387_immune_system_phenotype1.63876755
42MP0001790_abnormal_immune_system1.63876755
43MP0000465_gastrointestinal_hemorrhage1.63654670
44MP0000689_abnormal_spleen_morphology1.62984326
45MP0002429_abnormal_blood_cell1.62639919
46MP0001851_eye_inflammation1.61690560
47MP0005174_abnormal_tail_pigmentation1.59411614
48MP0002132_abnormal_respiratory_system1.58552422
49MP0001845_abnormal_inflammatory_respons1.57425578
50MP0009764_decreased_sensitivity_to1.53749613
51MP0003191_abnormal_cellular_cholesterol1.44138684
52MP0010155_abnormal_intestine_physiology1.31293711
53MP0008260_abnormal_autophagy1.27468395
54MP0000703_abnormal_thymus_morphology1.26435527
55MP0002006_tumorigenesis1.23247016
56MP0004185_abnormal_adipocyte_glucose1.23002181
57MP0004947_skin_inflammation1.22418619
58MP0008469_abnormal_protein_level1.22403900
59MP0003300_gastrointestinal_ulcer1.21210574
60MP0005076_abnormal_cell_differentiation1.16567320
61MP0009379_abnormal_foot_pigmentation1.15134919
62MP0003075_altered_response_to1.08826318
63MP0005083_abnormal_biliary_tract1.04732676
64MP0005164_abnormal_response_to1.04290144
65MP0009333_abnormal_splenocyte_physiolog1.01375570
66MP0009763_increased_sensitivity_to0.97548346
67MP0000858_altered_metastatic_potential0.97030383
68MP0002998_abnormal_bone_remodeling0.95301800
69MP0003806_abnormal_nucleotide_metabolis0.95006974
70MP0004883_abnormal_blood_vessel0.94781368
71MP0002095_abnormal_skin_pigmentation0.94389930
72MP0003183_abnormal_peptide_metabolism0.94306024
73MP0001986_abnormal_taste_sensitivity0.92007736
74MP0008057_abnormal_DNA_replication0.90294439
75MP0005390_skeleton_phenotype0.88438314
76MP0002019_abnormal_tumor_incidence0.86025299
77MP0009765_abnormal_xenobiotic_induced0.84760091
78MP0003866_abnormal_defecation0.83016159
79MP0000681_abnormal_thyroid_gland0.80817166
80MP0004381_abnormal_hair_follicle0.78596174
81MP0008007_abnormal_cellular_replicative0.76350987
82MP0006036_abnormal_mitochondrial_physio0.73503220
83MP0004782_abnormal_surfactant_physiolog0.72360398
84MP0008873_increased_physiological_sensi0.67274201
85MP0000249_abnormal_blood_vessel0.66438258
86MP0005319_abnormal_enzyme/_coenzyme0.66437698
87MP0003795_abnormal_bone_structure0.66229644
88MP0005666_abnormal_adipose_tissue0.64479169
89MP0000343_altered_response_to0.63651135
90MP0001663_abnormal_digestive_system0.63157763
91MP0000598_abnormal_liver_morphology0.60791435
92MP0005166_decreased_susceptibility_to0.60523653
93MP0008961_abnormal_basal_metabolism0.58681634
94MP0000490_abnormal_crypts_of0.55948178
95MP0009931_abnormal_skin_appearance0.55417038
96MP0003448_altered_tumor_morphology0.54429777
97MP0005376_homeostasis/metabolism_phenot0.54192088
98MP0005584_abnormal_enzyme/coenzyme_acti0.54127095
99MP0008995_early_reproductive_senescence0.53959012
100MP0005165_increased_susceptibility_to0.52903425

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.50082979
2Recurrent abscess formation (HP:0002722)5.44695959
3Hypochromic microcytic anemia (HP:0004840)5.39004468
4Abnormality of the heme biosynthetic pathway (HP:0010472)5.02867734
5Thrombocytosis (HP:0001894)4.99259152
6Elevated erythrocyte sedimentation rate (HP:0003565)4.65888201
7Obstructive lung disease (HP:0006536)4.65822033
8Chronic obstructive pulmonary disease (HP:0006510)4.65822033
9Eczematoid dermatitis (HP:0000976)4.32524340
10Myositis (HP:0100614)4.26581668
11Amyloidosis (HP:0011034)4.26322511
12Recurrent gram-negative bacterial infections (HP:0005420)4.06985868
13Abnormality of macrophages (HP:0004311)4.06440195
14Granulocytopenia (HP:0001913)4.00282727
15Stomatitis (HP:0010280)3.79970488
16Recurrent skin infections (HP:0001581)3.79811466
17Meningitis (HP:0001287)3.78740913
18Recurrent fungal infections (HP:0002841)3.71767334
19Recurrent cutaneous fungal infections (HP:0011370)3.68925181
20Chronic mucocutaneous candidiasis (HP:0002728)3.68925181
21Hypochromic anemia (HP:0001931)3.66661380
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.61307669
23Abnormality of the prostate (HP:0008775)3.57246450
24Acute lymphatic leukemia (HP:0006721)3.53743049
25Prolonged bleeding time (HP:0003010)3.49047713
26Epistaxis (HP:0000421)3.37305763
27Mediastinal lymphadenopathy (HP:0100721)3.37285114
28Microcytic anemia (HP:0001935)3.19178730
29Chest pain (HP:0100749)3.16610601
30Periodontitis (HP:0000704)3.15988077
31Increased neuronal autofluorescent lipopigment (HP:0002074)3.10880210
32Cellulitis (HP:0100658)3.03573564
33Petechiae (HP:0000967)3.00623658
34Abnormality of iron homeostasis (HP:0011031)3.00086069
35Gingivitis (HP:0000230)2.99505463
36Acute myeloid leukemia (HP:0004808)2.97191585
37Dysostosis multiplex (HP:0000943)2.95956644
38Eosinophilia (HP:0001880)2.95837488
39Increased cerebral lipofuscin (HP:0011813)2.95077970
40Recurrent viral infections (HP:0004429)2.91509229
41Hemoptysis (HP:0002105)2.85031485
42Osteomyelitis (HP:0002754)2.84730245
43Increased serum ferritin (HP:0003281)2.81805417
44Orchitis (HP:0100796)2.81765461
45Leukocytosis (HP:0001974)2.81396378
46Urticaria (HP:0001025)2.79131171
47Vasculitis (HP:0002633)2.76940792
48Agammaglobulinemia (HP:0004432)2.76864135
49Hepatosplenomegaly (HP:0001433)2.74999237
50Abnormality of T cell physiology (HP:0011840)2.74009008
51Pulmonary infiltrates (HP:0002113)2.72112604
52Vacuolated lymphocytes (HP:0001922)2.70770033
53Gingival bleeding (HP:0000225)2.70494111
54Skin rash (HP:0000988)2.63736451
55Spondylolisthesis (HP:0003302)2.63309346
56Retrobulbar optic neuritis (HP:0100654)2.63211384
57Optic neuritis (HP:0100653)2.63211384
58Autoimmune thrombocytopenia (HP:0001973)2.60030826
59Increased IgE level (HP:0003212)2.59763281
60Panhypogammaglobulinemia (HP:0003139)2.59702859
61Abnormality of B cell number (HP:0010975)2.55377467
62Abnormality of transition element cation homeostasis (HP:0011030)2.52472705
63Gastrointestinal infarctions (HP:0005244)2.50069875
64Thoracic kyphosis (HP:0002942)2.46356112
65Encephalitis (HP:0002383)2.44849398
66Thrombophlebitis (HP:0004418)2.43380559
67Polycythemia (HP:0001901)2.41882141
68Hypergammaglobulinemia (HP:0010702)2.40830069
69B lymphocytopenia (HP:0010976)2.40743089
70Abnormal hemoglobin (HP:0011902)2.39286328
71Skin ulcer (HP:0200042)2.37773366
72Sepsis (HP:0100806)2.37381464
73Abnormality of liposaccharide metabolism (HP:0010968)2.34027024
74Abnormality of glycosphingolipid metabolism (HP:0004343)2.34027024
75Abnormality of glycolipid metabolism (HP:0010969)2.34027024
76Pulmonary embolism (HP:0002204)2.31608134
77Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.26743338
78Spontaneous hematomas (HP:0007420)2.23689062
79Arterial thrombosis (HP:0004420)2.23099389
80Abnormality of eosinophils (HP:0001879)2.20612740
81Episodic fever (HP:0001954)2.20450341
82Keratoconjunctivitis sicca (HP:0001097)2.17627603
83Poikilocytosis (HP:0004447)2.16491738
84Glomerulopathy (HP:0100820)2.14340287
85Inflammation of the large intestine (HP:0002037)2.13379819
86Abnormality of the pleura (HP:0002103)2.11486729
87Paralysis (HP:0003470)2.10149217
88Gastrointestinal inflammation (HP:0004386)2.09845270
89Gangrene (HP:0100758)2.08937196
90Pallor (HP:0000980)2.08415369
91Autoimmune hemolytic anemia (HP:0001890)2.07398793
92Abnormality of male internal genitalia (HP:0000022)2.06416312
93Abnormality of T cells (HP:0002843)2.04591265
94Paresthesia (HP:0003401)2.03598722
95Impaired platelet aggregation (HP:0003540)2.03386036
96Abnormal platelet function (HP:0011869)2.03386036
97Colitis (HP:0002583)2.03069690
98Pulmonary fibrosis (HP:0002206)2.02083730
99Keratoconjunctivitis (HP:0001096)2.02023048
100Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00711466

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.40870772
2MAP2K33.63006490
3FES3.31349595
4PRPF4B2.77763468
5GRK62.75205575
6TEC2.72158978
7TESK22.50956200
8KIT2.43843747
9BLK2.43297378
10ERN12.35961441
11BTK2.34926568
12MAP4K12.25297368
13TNK22.15256346
14SYK2.07492117
15TYK22.03530888
16ZAP701.99502521
17IRAK41.82501121
18MAP3K61.78397253
19PIK3CG1.77584325
20TBK11.68763329
21TRPM71.64829211
22CSF1R1.54620331
23HCK1.49759889
24FLT31.47358042
25LYN1.47342243
26CDK61.43461237
27TAOK31.40179311
28CDK191.38387347
29MAP3K141.34732041
30BMPR21.32300948
31MAP3K111.30740042
32ITK1.30306709
33CDK121.25045382
34TAOK11.23972414
35MOS1.22613874
36TAOK21.19541637
37TRIB31.08714579
38SCYL21.07041441
39GRK71.00361772
40CSK0.97210973
41TXK0.95249948
42LCK0.94393045
43JAK20.94216312
44MAP3K30.93626873
45IKBKE0.92435245
46HIPK20.92333496
47ABL20.91270414
48IKBKB0.90820427
49MAPK40.88609665
50MAP3K130.87948418
51TGFBR20.86975252
52MAP3K10.84923837
53KDR0.81886540
54RPS6KA40.80875244
55JAK30.79706675
56STK100.77824037
57PDK10.77598290
58CDK40.74192847
59MARK30.71625214
60MATK0.69789862
61RPS6KC10.69105488
62RPS6KL10.69105488
63LRRK20.68050917
64PDPK10.65519522
65RPS6KA60.61488738
66MAP2K60.61360420
67MAP3K50.61249798
68MAP2K20.60758648
69PIM10.60635613
70MAP2K40.59968249
71FGR0.58731821
72YES10.58215961
73IRAK20.55687838
74MAPK120.55255274
75PRKCQ0.54335500
76BCKDK0.53331934
77EEF2K0.52339069
78RPS6KB20.50138250
79ABL10.46183735
80MARK20.45909848
81IRAK10.44354890
82MAPK70.42391812
83TLK10.40576650
84MAPKAPK20.40491929
85VRK20.39788828
86GSK3A0.39429872
87PLK40.38634681
88VRK10.37338555
89IRAK30.36116877
90MAPK30.34627534
91MAPK110.34343793
92RPS6KA50.34150271
93PRKCD0.33863394
94PKN20.32628682
95RET0.32477761
96MAPK150.31060375
97FYN0.29150249
98STK110.28478895
99CLK10.27959621
100PIK3CA0.25941605

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.44418719
2Other glycan degradation_Homo sapiens_hsa005113.66695069
3Leishmaniasis_Homo sapiens_hsa051402.91932916
4Osteoclast differentiation_Homo sapiens_hsa043802.48554183
5Staphylococcus aureus infection_Homo sapiens_hsa051502.33843216
6Renin-angiotensin system_Homo sapiens_hsa046142.31368258
7Malaria_Homo sapiens_hsa051442.25836144
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.09852412
9B cell receptor signaling pathway_Homo sapiens_hsa046622.08658989
10Acute myeloid leukemia_Homo sapiens_hsa052211.90420098
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.83847108
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.83664580
13Tuberculosis_Homo sapiens_hsa051521.83550044
14Hematopoietic cell lineage_Homo sapiens_hsa046401.77822015
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.72779307
16African trypanosomiasis_Homo sapiens_hsa051431.66701667
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.56846867
18Transcriptional misregulation in cancer_Homo sapiens_hsa052021.54643284
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54297197
20DNA replication_Homo sapiens_hsa030301.53414679
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52447767
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.51402189
23Allograft rejection_Homo sapiens_hsa053301.50482864
24Systemic lupus erythematosus_Homo sapiens_hsa053221.50400563
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46163009
26Platelet activation_Homo sapiens_hsa046111.44403530
27Graft-versus-host disease_Homo sapiens_hsa053321.39405529
28Legionellosis_Homo sapiens_hsa051341.38610504
29Primary immunodeficiency_Homo sapiens_hsa053401.38203528
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33232982
31Autoimmune thyroid disease_Homo sapiens_hsa053201.33219151
32Lysosome_Homo sapiens_hsa041421.31916424
33Influenza A_Homo sapiens_hsa051641.30652837
34Non-small cell lung cancer_Homo sapiens_hsa052231.30621190
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27587377
36Ribosome_Homo sapiens_hsa030101.24668957
37Pertussis_Homo sapiens_hsa051331.16776019
38Herpes simplex infection_Homo sapiens_hsa051681.16123950
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13555541
40Phagosome_Homo sapiens_hsa041451.12630649
41Amoebiasis_Homo sapiens_hsa051461.12371219
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11479359
43Pentose phosphate pathway_Homo sapiens_hsa000301.09678332
44Pancreatic cancer_Homo sapiens_hsa052121.09486262
45Antigen processing and presentation_Homo sapiens_hsa046121.07959754
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07817502
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.07658473
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.04526778
49Measles_Homo sapiens_hsa051621.03626267
50Toxoplasmosis_Homo sapiens_hsa051451.01961714
51Hepatitis B_Homo sapiens_hsa051610.99420361
52Chronic myeloid leukemia_Homo sapiens_hsa052200.95894759
53Type I diabetes mellitus_Homo sapiens_hsa049400.94143973
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.93395751
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.92010706
56Base excision repair_Homo sapiens_hsa034100.91527645
57T cell receptor signaling pathway_Homo sapiens_hsa046600.91495134
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.91380489
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88661732
60Rheumatoid arthritis_Homo sapiens_hsa053230.87868038
61Chemokine signaling pathway_Homo sapiens_hsa040620.85071839
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81345590
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80907123
64VEGF signaling pathway_Homo sapiens_hsa043700.79551315
65Salmonella infection_Homo sapiens_hsa051320.79350002
66Shigellosis_Homo sapiens_hsa051310.78717183
67TNF signaling pathway_Homo sapiens_hsa046680.74269157
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.66619469
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66364293
70Viral myocarditis_Homo sapiens_hsa054160.62525778
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.58929693
72Apoptosis_Homo sapiens_hsa042100.58336238
73Epstein-Barr virus infection_Homo sapiens_hsa051690.56892946
74Viral carcinogenesis_Homo sapiens_hsa052030.56855348
75Regulation of autophagy_Homo sapiens_hsa041400.56429886
76Hepatitis C_Homo sapiens_hsa051600.55854641
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54656852
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54495892
79Choline metabolism in cancer_Homo sapiens_hsa052310.51177905
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48768099
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47911679
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46810145
83GnRH signaling pathway_Homo sapiens_hsa049120.46418655
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.46299705
85FoxO signaling pathway_Homo sapiens_hsa040680.40586477
86Renal cell carcinoma_Homo sapiens_hsa052110.39950783
87HIF-1 signaling pathway_Homo sapiens_hsa040660.37995906
88HTLV-I infection_Homo sapiens_hsa051660.36766039
89Type II diabetes mellitus_Homo sapiens_hsa049300.35781175
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.35589458
91Prolactin signaling pathway_Homo sapiens_hsa049170.34778760
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.33758801
93Homologous recombination_Homo sapiens_hsa034400.33280154
94Salivary secretion_Homo sapiens_hsa049700.32471906
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.30897783
96Dorso-ventral axis formation_Homo sapiens_hsa043200.30485124
97mTOR signaling pathway_Homo sapiens_hsa041500.30194525
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.30094138
99Colorectal cancer_Homo sapiens_hsa052100.28854194
100Inositol phosphate metabolism_Homo sapiens_hsa005620.28094465

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