RNASE3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1killing of cells of other organism (GO:0031640)9.68330487
2disruption of cells of other organism (GO:0044364)9.68330487
3defense response to fungus (GO:0050832)9.63651217
4disruption of cells of other organism involved in symbiotic interaction (GO:0051818)9.05562137
5killing of cells in other organism involved in symbiotic interaction (GO:0051883)9.05562137
6positive regulation of interleukin-8 biosynthetic process (GO:0045416)8.88011416
7response to fungus (GO:0009620)7.79704979
8negative regulation of growth of symbiont in host (GO:0044130)7.58119575
9negative regulation of growth of symbiont involved in interaction with host (GO:0044146)7.58119575
10modulation of growth of symbiont involved in interaction with host (GO:0044144)7.58119575
11regulation of growth of symbiont in host (GO:0044126)7.58119575
12* antibacterial humoral response (GO:0019731)7.41356864
13* innate immune response in mucosa (GO:0002227)7.06906231
14neutrophil mediated immunity (GO:0002446)7.04537371
15* antimicrobial humoral response (GO:0019730)6.82189495
16cellular extravasation (GO:0045123)6.81014248
17regulation of interleukin-8 biosynthetic process (GO:0045414)6.42109755
18response to peptidoglycan (GO:0032494)6.36443665
19oxygen transport (GO:0015671)6.25782002
20protoporphyrinogen IX metabolic process (GO:0046501)5.90104632
21negative regulation of interleukin-8 production (GO:0032717)5.80902959
22* mucosal immune response (GO:0002385)5.67668136
23hydrogen peroxide catabolic process (GO:0042744)5.63325045
24protoporphyrinogen IX biosynthetic process (GO:0006782)5.59495038
25neutrophil activation involved in immune response (GO:0002283)5.50766075
26hemoglobin metabolic process (GO:0020027)5.47498346
27myeloid leukocyte mediated immunity (GO:0002444)5.43941896
28* organ or tissue specific immune response (GO:0002251)5.40608921
29imidazole-containing compound metabolic process (GO:0052803)5.33289787
30detection of bacterium (GO:0016045)5.31416559
31cell killing (GO:0001906)5.26776462
32gas transport (GO:0015669)5.24640627
33detection of other organism (GO:0098543)5.24183331
34neutrophil activation (GO:0042119)5.21708746
35granulocyte activation (GO:0036230)4.62631326
36negative regulation of phagocytosis (GO:0050765)4.59231518
37cell wall macromolecule catabolic process (GO:0016998)4.35287306
38negative regulation of erythrocyte differentiation (GO:0045647)4.30364984
39superoxide anion generation (GO:0042554)4.27586791
40positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.25528118
41respiratory burst (GO:0045730)4.20918664
42porphyrin-containing compound biosynthetic process (GO:0006779)4.17684508
43reactive oxygen species biosynthetic process (GO:1903409)4.14296542
44regulation of chemokine biosynthetic process (GO:0045073)4.05418156
45intracellular estrogen receptor signaling pathway (GO:0030520)3.91503215
46heme biosynthetic process (GO:0006783)3.87973178
47positive regulation of B cell differentiation (GO:0045579)3.87230609
48* defense response to Gram-positive bacterium (GO:0050830)3.85779295
49hydrogen peroxide metabolic process (GO:0042743)3.76306697
50regulation of mast cell degranulation (GO:0043304)3.73509722
51regulation of myeloid leukocyte mediated immunity (GO:0002886)3.69747680
52positive regulation of gamma-delta T cell activation (GO:0046645)3.63198587
53microglial cell activation (GO:0001774)3.60574487
54tetrapyrrole biosynthetic process (GO:0033014)3.60248988
55* defense response to bacterium (GO:0042742)3.59143032
56cell wall macromolecule metabolic process (GO:0044036)3.58196445
57angiotensin maturation (GO:0002003)3.51749529
58regulation of leukocyte degranulation (GO:0043300)3.47585869
59regulation of mast cell activation involved in immune response (GO:0033006)3.46825846
60leukotriene biosynthetic process (GO:0019370)3.36947914
61detection of external biotic stimulus (GO:0098581)3.36940341
62erythrocyte development (GO:0048821)3.26686019
63porphyrin-containing compound metabolic process (GO:0006778)3.24616878
64positive regulation of granulocyte differentiation (GO:0030854)3.22855227
65regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.20946282
66regulation of female gonad development (GO:2000194)3.18802922
67erythrocyte maturation (GO:0043249)3.18514262
68negative regulation of interleukin-6 production (GO:0032715)3.16571408
69* response to bacterium (GO:0009617)3.15599750
70macrophage differentiation (GO:0030225)3.13896250
71leukocyte migration involved in inflammatory response (GO:0002523)3.13773983
72leukocyte mediated cytotoxicity (GO:0001909)3.13157984
73positive regulation of mast cell degranulation (GO:0043306)3.13119556
74positive regulation of mast cell activation involved in immune response (GO:0033008)3.13119556
75regulation of regulated secretory pathway (GO:1903305)3.11313339
76myeloid cell development (GO:0061515)3.11190283
77leukocyte aggregation (GO:0070486)3.08427991
78heme metabolic process (GO:0042168)3.07480170
79leukocyte degranulation (GO:0043299)3.07471297
80definitive hemopoiesis (GO:0060216)3.07223351
81detection of biotic stimulus (GO:0009595)3.06498977
82response to muramyl dipeptide (GO:0032495)3.05551755
83modification by host of symbiont morphology or physiology (GO:0051851)3.05530884
84regulation of natural killer cell differentiation (GO:0032823)3.04218580
85response to methylmercury (GO:0051597)3.02057589
86regulation of MHC class II biosynthetic process (GO:0045346)3.02011597
87interaction with symbiont (GO:0051702)2.99284135
88negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.94272477
89modification of morphology or physiology of other organism (GO:0035821)2.92548109
90mannose metabolic process (GO:0006013)2.90903584
91regulation of mast cell activation (GO:0033003)2.86808352
92leukotriene metabolic process (GO:0006691)2.83551302
93superoxide metabolic process (GO:0006801)2.83341650
94negative regulation of bone mineralization (GO:0030502)2.82883427
95mast cell activation (GO:0045576)2.79567580
96positive regulation of mast cell activation (GO:0033005)2.79113289
97regulation of B cell differentiation (GO:0045577)2.78376511
98regulation of response to osmotic stress (GO:0047484)2.73513081
99negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.71324430
100myeloid cell activation involved in immune response (GO:0002275)2.66427059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human5.31708808
2VDR_24763502_ChIP-Seq_THP-1_Human4.35938160
3SCL_19346495_ChIP-Seq_HPC-7_Human4.20152590
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.70771656
5MYB_21317192_ChIP-Seq_ERMYB_Mouse3.60580892
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.48398897
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.33985103
8GATA1_22025678_ChIP-Seq_K562_Human3.26227231
9E2F7_22180533_ChIP-Seq_HELA_Human3.18394905
10* SPI1_23547873_ChIP-Seq_NB4_Human3.05247125
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.67995639
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.61470117
13GATA1_19941826_ChIP-Seq_K562_Human2.59971070
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.54365720
15MYB_26560356_Chip-Seq_TH2_Human2.31248074
16MYC_22102868_ChIP-Seq_BL_Human2.29508620
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.26160813
18BRD4_27068464_Chip-Seq_AML-cells_Mouse2.24055797
19UTX_26944678_Chip-Seq_JUKART_Human2.23344626
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.18518324
21RUNX1_22412390_ChIP-Seq_EML_Mouse2.13640458
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.13293959
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.09375563
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07693362
25GATA1_19941827_ChIP-Seq_MEL_Mouse2.05562155
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.04435333
27GATA1_22383799_ChIP-Seq_G1ME_Mouse2.01891491
28IRF8_21731497_ChIP-ChIP_J774_Mouse2.01706405
29SPI1_23127762_ChIP-Seq_K562_Human1.98559251
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.96281291
31MAF_26560356_Chip-Seq_TH1_Human1.95222149
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88983971
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.86134261
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84974391
35TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.83938692
36TCF7_22412390_ChIP-Seq_EML_Mouse1.82082227
37MYB_26560356_Chip-Seq_TH1_Human1.77848131
38VDR_24787735_ChIP-Seq_THP-1_Human1.77451364
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76799219
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.76494007
41GATA2_22383799_ChIP-Seq_G1ME_Mouse1.74987439
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.74060408
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71109149
44GATA2_19941826_ChIP-Seq_K562_Human1.69354063
45* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.69321647
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68747348
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64831894
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59054507
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57743700
50PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.55035380
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54658881
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.50942494
53PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50044172
54LXR_22292898_ChIP-Seq_THP-1_Human1.46749160
55MAF_26560356_Chip-Seq_TH2_Human1.46487663
56FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44931657
57STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.42318546
58SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40907079
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40676953
60KDM2B_26808549_Chip-Seq_DND41_Human1.39198631
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.38053579
62RUNX_20019798_ChIP-Seq_JUKART_Human1.36952110
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36288023
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35973810
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35556115
66BCOR_27268052_Chip-Seq_Bcells_Human1.35452419
67BCL6_27268052_Chip-Seq_Bcells_Human1.35000923
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29977215
69NCOR1_26117541_ChIP-Seq_K562_Human1.28891997
70GATA3_27048872_Chip-Seq_THYMUS_Human1.28192540
71SPI1_20517297_ChIP-Seq_HL60_Human1.25395633
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23057805
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23009045
74KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21825805
75KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.21076195
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18344915
77PU_27001747_Chip-Seq_BMDM_Mouse1.17860838
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17748694
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17427527
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16874475
81PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16261586
82CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16103461
83* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14293558
84STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12208607
85P68_20966046_ChIP-Seq_HELA_Human1.11364322
86GATA3_26560356_Chip-Seq_TH2_Human1.10216443
87Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10005490
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06897149
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04429472
90CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04167343
91TFEB_21752829_ChIP-Seq_HELA_Human0.99164088
92P300_27268052_Chip-Seq_Bcells_Human0.98600941
93* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96543309
94CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96513714
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96316070
96ETS1_22383799_ChIP-Seq_G1ME_Mouse0.94249265
97CIITA_25753668_ChIP-Seq_RAJI_Human0.94146783
98RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93062262
99ELK3_25401928_ChIP-Seq_HUVEC_Human0.91365817
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.91343397

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.85816624
2MP0004147_increased_porphyrin_level4.75955921
3MP0003656_abnormal_erythrocyte_physiolo4.38104850
4MP0002419_abnormal_innate_immunity3.30121058
5MP0003436_decreased_susceptibility_to3.28132087
6MP0003172_abnormal_lysosome_physiology3.18511295
7MP0009278_abnormal_bone_marrow3.15425504
8MP0005025_abnormal_response_to3.13776600
9MP0001545_abnormal_hematopoietic_system3.02265548
10MP0005397_hematopoietic_system_phenotyp3.02265548
11MP0009785_altered_susceptibility_to3.00347397
12MP0005464_abnormal_platelet_physiology2.80916836
13MP0001835_abnormal_antigen_presentation2.58808228
14MP0005058_abnormal_lysosome_morphology2.35190691
15MP0002396_abnormal_hematopoietic_system2.30026436
16MP0002420_abnormal_adaptive_immunity2.12809549
17MP0001819_abnormal_immune_cell2.08570899
18MP0002398_abnormal_bone_marrow2.03318536
19MP0005083_abnormal_biliary_tract1.98320685
20MP0005000_abnormal_immune_tolerance1.93832715
21MP0004808_abnormal_hematopoietic_stem1.93741494
22MP0002166_altered_tumor_susceptibility1.80210052
23MP0001800_abnormal_humoral_immune1.78271539
24MP0002722_abnormal_immune_system1.74451968
25MP0002452_abnormal_antigen_presenting1.74011011
26MP0002009_preneoplasia1.72678436
27MP0002148_abnormal_hypersensitivity_rea1.71691242
28MP0000716_abnormal_immune_system1.71145388
29MP0002723_abnormal_immune_serum1.66992267
30MP0000685_abnormal_immune_system1.66428380
31MP0002429_abnormal_blood_cell1.61680037
32MP0000689_abnormal_spleen_morphology1.60597501
33MP0002405_respiratory_system_inflammati1.58206002
34MP0005075_abnormal_melanosome_morpholog1.57950241
35MP0000465_gastrointestinal_hemorrhage1.57712460
36MP0003724_increased_susceptibility_to1.55955645
37MP0001533_abnormal_skeleton_physiology1.53982367
38MP0000015_abnormal_ear_pigmentation1.52873022
39MP0003763_abnormal_thymus_physiology1.52456318
40MP0008260_abnormal_autophagy1.50442189
41MP0001851_eye_inflammation1.49354420
42MP0001845_abnormal_inflammatory_respons1.49201931
43MP0004185_abnormal_adipocyte_glucose1.47688002
44MP0003828_pulmonary_edema1.45818848
45MP0003191_abnormal_cellular_cholesterol1.44926814
46MP0009764_decreased_sensitivity_to1.40287027
47MP0005387_immune_system_phenotype1.40235389
48MP0001790_abnormal_immune_system1.40235389
49MP0000569_abnormal_digit_pigmentation1.35446747
50MP0001853_heart_inflammation1.35304831
51MP0005174_abnormal_tail_pigmentation1.34316063
52MP0006082_CNS_inflammation1.33916030
53MP0005671_abnormal_response_to1.31330487
54MP0002132_abnormal_respiratory_system1.23701403
55MP0000703_abnormal_thymus_morphology1.19006658
56MP0009333_abnormal_splenocyte_physiolog1.15097717
57MP0009379_abnormal_foot_pigmentation1.14929870
58MP0008469_abnormal_protein_level1.10743893
59MP0005076_abnormal_cell_differentiation1.09472589
60MP0002006_tumorigenesis1.09278507
61MP0002095_abnormal_skin_pigmentation1.07020055
62MP0008057_abnormal_DNA_replication1.06960465
63MP0003806_abnormal_nucleotide_metabolis1.05393419
64MP0005164_abnormal_response_to1.05115948
65MP0001986_abnormal_taste_sensitivity1.02723341
66MP0010155_abnormal_intestine_physiology1.02448218
67MP0009763_increased_sensitivity_to0.99147477
68MP0004947_skin_inflammation0.94026069
69MP0003183_abnormal_peptide_metabolism0.93696111
70MP0003075_altered_response_to0.92597455
71MP0003300_gastrointestinal_ulcer0.91019578
72MP0006036_abnormal_mitochondrial_physio0.89789908
73MP0002019_abnormal_tumor_incidence0.89525801
74MP0009765_abnormal_xenobiotic_induced0.88804403
75MP0003045_fibrosis0.87665014
76MP0002877_abnormal_melanocyte_morpholog0.83995618
77MP0008995_early_reproductive_senescence0.80370745
78MP0008873_increased_physiological_sensi0.79689952
79MP0005319_abnormal_enzyme/_coenzyme0.79682946
80MP0005636_abnormal_mineral_homeostasis0.79038515
81MP0000858_altered_metastatic_potential0.78010132
82MP0009931_abnormal_skin_appearance0.77351271
83MP0004883_abnormal_blood_vessel0.75564274
84MP0001663_abnormal_digestive_system0.72722962
85MP0005390_skeleton_phenotype0.71726915
86MP0003795_abnormal_bone_structure0.71713859
87MP0005266_abnormal_metabolism0.70381408
88MP0000249_abnormal_blood_vessel0.69151629
89MP0000598_abnormal_liver_morphology0.68932622
90MP0002998_abnormal_bone_remodeling0.68380460
91MP0005666_abnormal_adipose_tissue0.67626019
92MP0005376_homeostasis/metabolism_phenot0.61712790
93MP0000343_altered_response_to0.61165813
94MP0003186_abnormal_redox_activity0.61022302
95MP0010094_abnormal_chromosome_stability0.60043930
96MP0008961_abnormal_basal_metabolism0.60009591
97MP0005535_abnormal_body_temperature0.59719459
98MP0003111_abnormal_nucleus_morphology0.59599719
99MP0003638_abnormal_response/metabolism_0.57270411
100MP0004381_abnormal_hair_follicle0.57069002

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)8.99276789
2Abnormality of the heme biosynthetic pathway (HP:0010472)8.97246135
3Hypochromic anemia (HP:0001931)5.34559299
4Thrombocytosis (HP:0001894)5.19921783
5Microcytic anemia (HP:0001935)4.84362955
6Obstructive lung disease (HP:0006536)4.78091803
7Chronic obstructive pulmonary disease (HP:0006510)4.78091803
8Recurrent abscess formation (HP:0002722)4.67862632
9Recurrent bacterial skin infections (HP:0005406)4.66188930
10Poikilocytosis (HP:0004447)4.47596345
11Abnormal hemoglobin (HP:0011902)4.24224479
12Granulocytopenia (HP:0001913)3.98575137
13Eczematoid dermatitis (HP:0000976)3.91804982
14Polycythemia (HP:0001901)3.86941107
15Prolonged bleeding time (HP:0003010)3.70605830
16Recurrent gram-negative bacterial infections (HP:0005420)3.68891912
17Elevated erythrocyte sedimentation rate (HP:0003565)3.62653212
18Paralysis (HP:0003470)3.50804227
19Abnormality of macrophages (HP:0004311)3.50386184
20Meningitis (HP:0001287)3.50292920
21Abnormality of iron homeostasis (HP:0011031)3.49384653
22Epistaxis (HP:0000421)3.45079157
23Abnormality of the prostate (HP:0008775)3.37478853
24Myositis (HP:0100614)3.25409179
25Petechiae (HP:0000967)3.22626747
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.20983860
27Periodontitis (HP:0000704)3.19272699
28Stomatitis (HP:0010280)3.15971599
29Amyloidosis (HP:0011034)3.13945255
30Cholelithiasis (HP:0001081)3.11445364
31Eosinophilia (HP:0001880)3.10539998
32Recurrent skin infections (HP:0001581)3.07521284
33Recurrent fungal infections (HP:0002841)3.01087220
34Osteomyelitis (HP:0002754)3.00839529
35Abnormality of transition element cation homeostasis (HP:0011030)3.00636835
36Toxemia of pregnancy (HP:0100603)2.98638348
37Chest pain (HP:0100749)2.97459832
38Mediastinal lymphadenopathy (HP:0100721)2.93654361
39Chronic mucocutaneous candidiasis (HP:0002728)2.86999322
40Recurrent cutaneous fungal infections (HP:0011370)2.86999322
41Cellulitis (HP:0100658)2.78954420
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.74571121
43Urticaria (HP:0001025)2.74344923
44Abnormal gallbladder morphology (HP:0012437)2.73558028
45Gingivitis (HP:0000230)2.72916832
46Reticulocytosis (HP:0001923)2.71494205
47Hepatosplenomegaly (HP:0001433)2.68921203
48Thrombophlebitis (HP:0004418)2.68617528
49Skin rash (HP:0000988)2.67804565
50Increased serum ferritin (HP:0003281)2.67394362
51Leukocytosis (HP:0001974)2.61388924
52Agammaglobulinemia (HP:0004432)2.60455175
53Acute lymphatic leukemia (HP:0006721)2.58542460
54Pallor (HP:0000980)2.58227766
55Hemoptysis (HP:0002105)2.54675325
56Increased cerebral lipofuscin (HP:0011813)2.53702654
57Diaphragmatic weakness (HP:0009113)2.48272837
58Abnormality of B cell number (HP:0010975)2.48219049
59Vasculitis (HP:0002633)2.45634197
60Pulmonary infiltrates (HP:0002113)2.45064462
61Autoimmune thrombocytopenia (HP:0001973)2.41917783
62Gastrointestinal infarctions (HP:0005244)2.37794595
63Acute myeloid leukemia (HP:0004808)2.37621825
64Gingival bleeding (HP:0000225)2.36519983
65Abnormality of T cell physiology (HP:0011840)2.36348961
66B lymphocytopenia (HP:0010976)2.35708445
67Hypergammaglobulinemia (HP:0010702)2.33947151
68Recurrent viral infections (HP:0004429)2.33549491
69Skin ulcer (HP:0200042)2.32760822
70Ureteral stenosis (HP:0000071)2.31836971
71Sepsis (HP:0100806)2.31660248
72Increased IgE level (HP:0003212)2.30624027
73Abnormality of eosinophils (HP:0001879)2.28688112
74Paresthesia (HP:0003401)2.26687942
75Dysostosis multiplex (HP:0000943)2.25258625
76Abnormality of the fingertips (HP:0001211)2.22430454
77Ureteral obstruction (HP:0006000)2.22093224
78Acanthocytosis (HP:0001927)2.18356516
79Abnormality of reticulocytes (HP:0004312)2.18166797
80Abnormality of the pericardium (HP:0001697)2.16348795
81Vacuolated lymphocytes (HP:0001922)2.12038388
82Panhypogammaglobulinemia (HP:0003139)2.11349108
83Systemic lupus erythematosus (HP:0002725)2.08976858
84Ileus (HP:0002595)2.08803509
85Thoracic kyphosis (HP:0002942)2.08041809
86Hypertensive crisis (HP:0100735)2.06447223
87Abnormality of the gallbladder (HP:0005264)2.04982103
88Pulmonary embolism (HP:0002204)2.04827960
89Abnormality of the pleura (HP:0002103)2.04563373
90Spondylolisthesis (HP:0003302)2.03823351
91Abnormal platelet function (HP:0011869)2.02470899
92Impaired platelet aggregation (HP:0003540)2.02470899
93Pulmonary fibrosis (HP:0002206)2.00827305
94Abnormality of glycolipid metabolism (HP:0010969)1.99841570
95Abnormality of liposaccharide metabolism (HP:0010968)1.99841570
96Abnormality of glycosphingolipid metabolism (HP:0004343)1.99841570
97Glomerulopathy (HP:0100820)1.99652567
98Cutaneous photosensitivity (HP:0000992)1.96670197
99Abnormality of male internal genitalia (HP:0000022)1.94889175
100Pustule (HP:0200039)1.94602212

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K34.44159825
2RIPK44.25391466
3GRK63.37320313
4FES3.20434833
5PRPF4B3.09381624
6TEC2.57094115
7ERN12.49543758
8TNK22.43832859
9TESK22.20046918
10KIT2.16482610
11BTK2.07021256
12TAOK12.07006831
13SYK2.06169653
14MAP3K112.05586039
15MAP4K11.99059658
16MAP3K61.98828269
17ZAP701.88164821
18TAOK21.86180654
19TRPM71.80619949
20CDK191.79440535
21TYK21.77471376
22BLK1.77460453
23PIK3CG1.68924035
24SCYL21.54538778
25IRAK41.50025651
26KDR1.43596875
27MAP3K31.43113474
28LYN1.42809243
29HCK1.30156709
30CDK61.28903419
31BMPR21.26736102
32TBK11.22061356
33CDK121.20369133
34CSF1R1.12664804
35ITK1.08174678
36TAOK31.06146166
37MAP3K141.05505452
38FLT31.01563511
39TRIB30.97414774
40JAK20.96383116
41MAPK40.92305910
42HIPK20.90116331
43MAP3K50.88231803
44MAP3K10.87442438
45MAP2K60.83041083
46MAP2K40.79526049
47LCK0.79274635
48RPS6KA40.77640765
49MOS0.76903898
50FGR0.74963938
51MARK30.74444839
52CDK40.74399057
53PDK10.72188234
54RPS6KL10.71970264
55RPS6KC10.71970264
56PDPK10.69572439
57EIF2AK10.67733632
58ABL20.66856477
59IKBKE0.66401850
60LRRK20.66278061
61CLK10.65495142
62CSK0.65233829
63PTK2B0.63581754
64MAP3K130.62999880
65RPS6KA60.62368137
66TXK0.62164705
67MAPK120.60574706
68MAP2K20.59999839
69GRK70.59500324
70IKBKB0.59035461
71TGFBR20.58748517
72PIM10.58163280
73JAK30.56811386
74DAPK20.55011778
75PLK40.54462462
76YES10.52044035
77PIK3CA0.51900498
78MATK0.50975842
79STK100.48222599
80PRKCQ0.48118013
81BCKDK0.47407885
82BRD40.46252957
83RPS6KB20.40984650
84VRK20.40983291
85RPS6KA50.39667936
86MARK20.39232007
87MAPKAPK20.38433614
88ABL10.37812985
89VRK10.34558624
90PRKCD0.33946878
91MAP3K80.33587689
92RET0.33366366
93GSK3A0.33075494
94MAPK30.32997379
95STK110.32757948
96MAPK110.32235911
97MKNK10.30768512
98GRK50.30347094
99NEK20.29858512
100RPS6KA20.28255137

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.46277353
2Malaria_Homo sapiens_hsa051443.38135385
3* Asthma_Homo sapiens_hsa053103.25008164
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.15929809
5African trypanosomiasis_Homo sapiens_hsa051432.72896601
6Renin-angiotensin system_Homo sapiens_hsa046142.66023114
7Leishmaniasis_Homo sapiens_hsa051402.55614650
8Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.29943342
9Staphylococcus aureus infection_Homo sapiens_hsa051502.17381831
10Osteoclast differentiation_Homo sapiens_hsa043802.14767138
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.10490934
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.01501147
13Hematopoietic cell lineage_Homo sapiens_hsa046401.97617254
14DNA replication_Homo sapiens_hsa030301.88027224
15B cell receptor signaling pathway_Homo sapiens_hsa046621.75661941
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.74983580
17Transcriptional misregulation in cancer_Homo sapiens_hsa052021.73844160
18Acute myeloid leukemia_Homo sapiens_hsa052211.71614670
19Tuberculosis_Homo sapiens_hsa051521.67309214
20Platelet activation_Homo sapiens_hsa046111.49030370
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.48587086
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48442540
23Pentose phosphate pathway_Homo sapiens_hsa000301.39647726
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.34200835
25Non-small cell lung cancer_Homo sapiens_hsa052231.33501008
26Base excision repair_Homo sapiens_hsa034101.33154198
27Lysosome_Homo sapiens_hsa041421.29562924
28Ribosome_Homo sapiens_hsa030101.29404226
29Systemic lupus erythematosus_Homo sapiens_hsa053221.27338853
30Amoebiasis_Homo sapiens_hsa051461.26013340
31Nitrogen metabolism_Homo sapiens_hsa009101.24785746
32Primary immunodeficiency_Homo sapiens_hsa053401.19201108
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.14678565
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14581804
35Legionellosis_Homo sapiens_hsa051341.14476440
36Phagosome_Homo sapiens_hsa041451.13922350
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10798544
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09187257
39Allograft rejection_Homo sapiens_hsa053301.08775092
40Influenza A_Homo sapiens_hsa051641.08324738
41Pancreatic cancer_Homo sapiens_hsa052121.05811879
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04647517
43Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.04521836
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.03841806
45Regulation of autophagy_Homo sapiens_hsa041401.03618936
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00723217
47Pertussis_Homo sapiens_hsa051330.98242398
48Herpes simplex infection_Homo sapiens_hsa051680.97213281
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96477448
50Autoimmune thyroid disease_Homo sapiens_hsa053200.96353902
51Chronic myeloid leukemia_Homo sapiens_hsa052200.93468232
52Graft-versus-host disease_Homo sapiens_hsa053320.92763201
53Hepatitis B_Homo sapiens_hsa051610.88080659
54Antigen processing and presentation_Homo sapiens_hsa046120.83499641
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.82414533
56Toxoplasmosis_Homo sapiens_hsa051450.81602475
57Jak-STAT signaling pathway_Homo sapiens_hsa046300.80515537
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80304964
59Measles_Homo sapiens_hsa051620.79802799
60Chemokine signaling pathway_Homo sapiens_hsa040620.76944574
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75986553
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75417686
63VEGF signaling pathway_Homo sapiens_hsa043700.72072068
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70698950
65Shigellosis_Homo sapiens_hsa051310.65422974
66Salivary secretion_Homo sapiens_hsa049700.63608933
67T cell receptor signaling pathway_Homo sapiens_hsa046600.63441474
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.62676677
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60299585
70Rheumatoid arthritis_Homo sapiens_hsa053230.60144523
71Salmonella infection_Homo sapiens_hsa051320.59784060
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56509987
73Type I diabetes mellitus_Homo sapiens_hsa049400.55768427
74Choline metabolism in cancer_Homo sapiens_hsa052310.55676574
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.50385750
76TNF signaling pathway_Homo sapiens_hsa046680.50125084
77Epstein-Barr virus infection_Homo sapiens_hsa051690.48624640
78Hepatitis C_Homo sapiens_hsa051600.48135994
79Collecting duct acid secretion_Homo sapiens_hsa049660.47137839
80HIF-1 signaling pathway_Homo sapiens_hsa040660.47066595
81Renal cell carcinoma_Homo sapiens_hsa052110.46885121
82Apoptosis_Homo sapiens_hsa042100.44734814
83Type II diabetes mellitus_Homo sapiens_hsa049300.44218589
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41798738
85FoxO signaling pathway_Homo sapiens_hsa040680.41537229
86GnRH signaling pathway_Homo sapiens_hsa049120.41130819
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.39177167
88Arachidonic acid metabolism_Homo sapiens_hsa005900.37413495
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37379445
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35705937
91Viral carcinogenesis_Homo sapiens_hsa052030.35527194
92HTLV-I infection_Homo sapiens_hsa051660.35444055
93Homologous recombination_Homo sapiens_hsa034400.34847981
94Fanconi anemia pathway_Homo sapiens_hsa034600.34423967
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33755308
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.32614274
97Bladder cancer_Homo sapiens_hsa052190.30247257
98Starch and sucrose metabolism_Homo sapiens_hsa005000.29993504
99mTOR signaling pathway_Homo sapiens_hsa041500.29394400
100Galactose metabolism_Homo sapiens_hsa000520.28904589

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