RNASE6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.27366268
2antigen processing and presentation of endogenous antigen (GO:0019883)6.63085526
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.87714629
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.87714629
5regulation of B cell receptor signaling pathway (GO:0050855)5.37236470
6response to peptidoglycan (GO:0032494)5.35330818
7mature B cell differentiation (GO:0002335)5.23567403
8positive regulation of B cell differentiation (GO:0045579)5.11315275
9negative regulation of interleukin-12 production (GO:0032695)4.83551351
10regulation of B cell differentiation (GO:0045577)4.73810208
11immunoglobulin mediated immune response (GO:0016064)4.71036020
12B cell receptor signaling pathway (GO:0050853)4.55270053
13mature B cell differentiation involved in immune response (GO:0002313)4.46895524
14megakaryocyte development (GO:0035855)4.35117197
15positive regulation of gamma-delta T cell activation (GO:0046645)4.31068406
16defense response to protozoan (GO:0042832)4.30919969
17detection of molecule of bacterial origin (GO:0032490)4.24587567
18detection of other organism (GO:0098543)4.22493986
19positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.18844475
20regulation of mast cell activation involved in immune response (GO:0033006)4.15114438
21detection of bacterium (GO:0016045)4.01286363
22positive regulation of leukocyte degranulation (GO:0043302)4.01159317
23B cell mediated immunity (GO:0019724)4.01088604
24negative regulation of B cell proliferation (GO:0030889)3.99899147
25neutrophil activation involved in immune response (GO:0002283)3.99162867
26regulation of interferon-beta biosynthetic process (GO:0045357)3.95511694
27detection of external biotic stimulus (GO:0098581)3.95467759
28regulation of hypersensitivity (GO:0002883)3.93202798
29cellular response to interferon-beta (GO:0035458)3.92178956
30respiratory burst (GO:0045730)3.90698689
31negative regulation of cell killing (GO:0031342)3.88244857
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.88244857
33response to protozoan (GO:0001562)3.82880786
34mast cell activation (GO:0045576)3.82331280
35positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.80595303
36regulation of myeloid leukocyte mediated immunity (GO:0002886)3.80176755
37antigen processing and presentation via MHC class Ib (GO:0002475)3.79048671
38cellular extravasation (GO:0045123)3.78985070
39cellular response to exogenous dsRNA (GO:0071360)3.77006258
40ribosomal small subunit assembly (GO:0000028)3.74463502
41interferon-gamma-mediated signaling pathway (GO:0060333)3.72852472
42regulation of leukocyte degranulation (GO:0043300)3.71687880
43response to interferon-beta (GO:0035456)3.69952678
44microglial cell activation (GO:0001774)3.68039605
45positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.67352876
46type I interferon signaling pathway (GO:0060337)3.65137625
47cellular response to type I interferon (GO:0071357)3.65137625
48heparin metabolic process (GO:0030202)3.64801980
49heparin biosynthetic process (GO:0030210)3.64801980
50response to type I interferon (GO:0034340)3.59554017
51regulation of interleukin-12 biosynthetic process (GO:0045075)3.58309964
52lipopolysaccharide-mediated signaling pathway (GO:0031663)3.53948277
53detection of biotic stimulus (GO:0009595)3.51589230
54regulation of T cell tolerance induction (GO:0002664)3.47335218
55macrophage activation (GO:0042116)3.46949786
56positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.46320070
57positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.43409893
58positive regulation of interferon-alpha production (GO:0032727)3.42650662
59regulation of alpha-beta T cell proliferation (GO:0046640)3.40174901
60cellular response to zinc ion (GO:0071294)3.39807564
61positive regulation of type 2 immune response (GO:0002830)3.32777456
62regulation of tolerance induction (GO:0002643)3.29317415
63regulation of T-helper 2 cell differentiation (GO:0045628)3.27413640
64positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.26007174
65positive regulation by symbiont of host defense response (GO:0052509)3.25822333
66modulation by symbiont of host defense response (GO:0052031)3.25822333
67modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.25822333
68modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.25822333
69positive regulation by organism of defense response of other organism involved in symbiotic interact3.25822333
70modulation by symbiont of host immune response (GO:0052553)3.25822333
71myeloid dendritic cell activation (GO:0001773)3.25287888
72positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.25263274
73positive regulation of macrophage differentiation (GO:0045651)3.24573782
74mast cell degranulation (GO:0043303)3.23965544
75mast cell activation involved in immune response (GO:0002279)3.23965544
76regulation of interferon-alpha production (GO:0032647)3.23136708
77positive regulation of mast cell activation involved in immune response (GO:0033008)3.22723886
78positive regulation of mast cell degranulation (GO:0043306)3.22723886
79positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.21861375
80neutrophil activation (GO:0042119)3.21695008
81cellular response to interferon-gamma (GO:0071346)3.21440120
82positive regulation of antigen processing and presentation (GO:0002579)3.17226828
83positive regulation of T cell mediated cytotoxicity (GO:0001916)3.14865082
84regulation of B cell proliferation (GO:0030888)3.14853445
85T-helper 1 type immune response (GO:0042088)3.13771957
86response to muramyl dipeptide (GO:0032495)3.13670932
87regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.13193708
88regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.13123420
89macrophage activation involved in immune response (GO:0002281)3.12601366
90signal peptide processing (GO:0006465)3.12144470
91negative regulation of myeloid cell apoptotic process (GO:0033033)3.10282319
92positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.07331633
93myeloid cell activation involved in immune response (GO:0002275)3.06801641
94B cell activation involved in immune response (GO:0002312)3.06586077
95regulation of mast cell activation (GO:0033003)3.05836327
96CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.05148465
97positive regulation of regulated secretory pathway (GO:1903307)3.04620855
98response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.03723465
99response to host immune response (GO:0052572)3.03723465
100regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.03394104
101regulation of regulated secretory pathway (GO:1903305)3.02379697
102cellular response to thyroid hormone stimulus (GO:0097067)3.02261054
103lymphoid progenitor cell differentiation (GO:0002320)3.01574719
104positive regulation of cellular amide metabolic process (GO:0034250)3.00185051
105regulation of type I interferon-mediated signaling pathway (GO:0060338)2.99638331
106B cell activation (GO:0042113)2.99413255
107response to interferon-gamma (GO:0034341)2.98757080
108regulation of B cell activation (GO:0050864)2.98722310
109myeloid dendritic cell differentiation (GO:0043011)2.98587139
110negative regulation of cytokine production involved in immune response (GO:0002719)2.97874579
111Arp2/3 complex-mediated actin nucleation (GO:0034314)2.97195436
112regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.96785937
113positive regulation of mast cell activation (GO:0033005)2.96158587
114positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.94856792
115regulation of inflammatory response to antigenic stimulus (GO:0002861)2.94532819
116production of molecular mediator involved in inflammatory response (GO:0002532)2.93222324
117negative regulation of B cell activation (GO:0050869)2.93188899
118glucosamine-containing compound catabolic process (GO:1901072)2.91850455
119execution phase of apoptosis (GO:0097194)2.90322996
120glycosphingolipid catabolic process (GO:0046479)2.90268420
121regulation of mast cell degranulation (GO:0043304)2.89852944
122granulocyte activation (GO:0036230)2.89806174
123regulation of antigen processing and presentation (GO:0002577)2.88605147
124positive regulation of monocyte chemotaxis (GO:0090026)2.88059246
125regulation of T-helper 1 cell differentiation (GO:0045625)2.87467305
126regulation of B cell apoptotic process (GO:0002902)2.87094002
127positive regulation of immunoglobulin mediated immune response (GO:0002891)2.82204564
128positive regulation of B cell mediated immunity (GO:0002714)2.82204564
129regulation of gamma-delta T cell differentiation (GO:0045586)2.81921214
130amino sugar catabolic process (GO:0046348)2.81586806
131positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.80814123
132B cell homeostasis (GO:0001782)2.80436542
133response to interferon-alpha (GO:0035455)2.78260633
134positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.78146437
135regulation of T cell mediated cytotoxicity (GO:0001914)2.77835453
136negative regulation of synaptic transmission, GABAergic (GO:0032229)2.77185259
137regulation of type 2 immune response (GO:0002828)2.77026844
138lymph node development (GO:0048535)2.76029720
139T cell migration (GO:0072678)2.75604592
140germinal center formation (GO:0002467)2.75447877
141positive regulation of interleukin-12 production (GO:0032735)2.75091091
142dendritic cell chemotaxis (GO:0002407)2.73912895
143B cell differentiation (GO:0030183)2.72129391
144natural killer cell mediated immunity (GO:0002228)2.71998381
145natural killer cell mediated cytotoxicity (GO:0042267)2.71998381
146regulation of gamma-delta T cell activation (GO:0046643)2.71890149
147regulation of dendritic cell antigen processing and presentation (GO:0002604)2.71092094
148dendritic cell differentiation (GO:0097028)2.70971126
149positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.69676624
150myeloid leukocyte activation (GO:0002274)2.69405825
151positive regulation of interferon-beta production (GO:0032728)2.68112837

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.33962989
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.30188165
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.01052451
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.54379027
5E2F7_22180533_ChIP-Seq_HELA_Human4.05293778
6SCL_19346495_ChIP-Seq_HPC-7_Human3.80859038
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.66387503
8* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.59880079
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.43157649
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.41386218
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.38664630
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.02641394
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.85734929
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.81760853
15* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.66126595
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.62688264
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.59240124
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.50049514
19* SPI1_23547873_ChIP-Seq_NB4_Human2.49087836
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.45708479
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.44508456
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.31550002
23* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.19606558
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19050493
25MYC_22102868_ChIP-Seq_BL_Human2.18379696
26MYB_26560356_Chip-Seq_TH2_Human2.18180725
27RUNX_20019798_ChIP-Seq_JUKART_Human2.18152525
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.15290802
29VDR_21846776_ChIP-Seq_THP-1_Human2.14711263
30* MYB_26560356_Chip-Seq_TH1_Human2.11731541
31GATA1_22025678_ChIP-Seq_K562_Human2.11357089
32MAF_26560356_Chip-Seq_TH1_Human2.07854671
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.02840818
34VDR_24763502_ChIP-Seq_THP-1_Human2.00847235
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.97451515
36* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.95798889
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92403323
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.89949083
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.87694085
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.87430628
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.87235348
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.85390948
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83593560
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81572127
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.80278373
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.72492006
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71289548
48* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.64884562
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64843467
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.64368872
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55027468
52* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.54993609
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53951331
54SPI1_23127762_ChIP-Seq_K562_Human1.50754467
55UTX_26944678_Chip-Seq_JUKART_Human1.49200999
56GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.46168181
57TCF7_22412390_ChIP-Seq_EML_Mouse1.40799186
58PU_27001747_Chip-Seq_BMDM_Mouse1.40755065
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.40404416
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39835805
61GATA3_27048872_Chip-Seq_THYMUS_Human1.35305892
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28235086
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27730459
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27716267
65PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26541191
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25978809
67* GATA1_19941827_ChIP-Seq_MEL_Mouse1.24615739
68* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21983083
69E2F4_17652178_ChIP-ChIP_JURKAT_Human1.18498978
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18265305
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18168608
72GATA3_26560356_Chip-Seq_TH2_Human1.17250713
73MAF_26560356_Chip-Seq_TH2_Human1.17028847
74EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.16177526
75PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15526456
76LXR_22292898_ChIP-Seq_THP-1_Human1.11744376
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10024668
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09889585
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09836720
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09703030
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.07255217
82TFEB_21752829_ChIP-Seq_HELA_Human1.06943847
83CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06378991
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05125605
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04430545
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03429769
87* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01363184
88STAT1_20625510_ChIP-Seq_HELA_Human1.00834485
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99974421
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97485972
91KDM2B_26808549_Chip-Seq_DND41_Human0.96950834
92GATA1_19941826_ChIP-Seq_K562_Human0.94869932
93VDR_23849224_ChIP-Seq_CD4+_Human0.94642719
94SPI1_20517297_ChIP-Seq_HL60_Human0.94165244
95ELK1_19687146_ChIP-ChIP_HELA_Human0.92250827
96ELK3_25401928_ChIP-Seq_HUVEC_Human0.92003579
97BCOR_27268052_Chip-Seq_Bcells_Human0.91883247
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91071703
99ELF1_20517297_ChIP-Seq_JURKAT_Human0.87964220
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84915779
101GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84818658
102KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.79427928
103ETS1_22383799_ChIP-Seq_G1ME_Mouse0.77341100
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74817266
105SMAD_19615063_ChIP-ChIP_OVARY_Human0.74602677
106CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.70678873
107EGR1_23403033_ChIP-Seq_LIVER_Mouse0.70655590
108* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.70406295
109NCOR1_26117541_ChIP-Seq_K562_Human0.70177612
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.69876294
111FOXP3_21729870_ChIP-Seq_TREG_Human0.69743493
112BCL6_27268052_Chip-Seq_Bcells_Human0.69647845
113CIITA_25753668_ChIP-Seq_RAJI_Human0.69286107
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68921839
115SRF_21415370_ChIP-Seq_HL-1_Mouse0.68768059
116FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68108767
117VDR_24787735_ChIP-Seq_THP-1_Human0.68094179
118CTCF_26484167_Chip-Seq_Bcells_Mouse0.68027349
119FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.66509843
120NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.66283892
121* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66216859
122E2F1_21310950_ChIP-Seq_MCF-7_Human0.65989530
123KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.65873259

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation6.26736201
2MP0005671_abnormal_response_to3.65812823
3MP0001800_abnormal_humoral_immune3.60995709
4MP0000685_abnormal_immune_system3.59705889
5MP0001790_abnormal_immune_system3.33289338
6MP0005387_immune_system_phenotype3.33289338
7MP0009785_altered_susceptibility_to3.24501024
8MP0002452_abnormal_antigen_presenting3.16166477
9MP0002148_abnormal_hypersensitivity_rea3.13113487
10MP0003436_decreased_susceptibility_to3.03558445
11MP0005000_abnormal_immune_tolerance3.01432243
12MP0005025_abnormal_response_to2.89904660
13MP0002723_abnormal_immune_serum2.85636249
14MP0001819_abnormal_immune_cell2.74707398
15MP0002420_abnormal_adaptive_immunity2.74674821
16MP0002419_abnormal_innate_immunity2.64036358
17MP0002398_abnormal_bone_marrow2.46789670
18MP0003303_peritoneal_inflammation2.43436402
19MP0005464_abnormal_platelet_physiology2.28888871
20MP0000716_abnormal_immune_system2.28453684
21MP0001853_heart_inflammation2.15832691
22MP0000689_abnormal_spleen_morphology2.12454746
23MP0002396_abnormal_hematopoietic_system2.06760723
24MP0006082_CNS_inflammation1.96434466
25MP0002429_abnormal_blood_cell1.94812892
26MP0002166_altered_tumor_susceptibility1.94165840
27MP0010155_abnormal_intestine_physiology1.91488737
28MP0005397_hematopoietic_system_phenotyp1.91398726
29MP0001545_abnormal_hematopoietic_system1.91398726
30MP0003763_abnormal_thymus_physiology1.89690077
31MP0005174_abnormal_tail_pigmentation1.86175782
32MP0002722_abnormal_immune_system1.85733697
33MP0004808_abnormal_hematopoietic_stem1.82415773
34MP0003806_abnormal_nucleotide_metabolis1.80329192
35MP0001845_abnormal_inflammatory_respons1.76738725
36MP0003724_increased_susceptibility_to1.74842768
37MP0002405_respiratory_system_inflammati1.72162244
38MP0009333_abnormal_splenocyte_physiolog1.69387957
39MP0002006_tumorigenesis1.58309368
40MP0001873_stomach_inflammation1.57616181
41MP0005075_abnormal_melanosome_morpholog1.52715114
42MP0005310_abnormal_salivary_gland1.51192370
43MP0000465_gastrointestinal_hemorrhage1.47545929
44MP0008469_abnormal_protein_level1.45000063
45MP0000604_amyloidosis1.42078436
46MP0006054_spinal_hemorrhage1.41338099
47MP0004947_skin_inflammation1.37659822
48MP0005451_abnormal_body_composition1.35242282
49MP0003866_abnormal_defecation1.31059154
50MP0004510_myositis1.30295665
51MP0005058_abnormal_lysosome_morphology1.29568403
52MP0000490_abnormal_crypts_of1.29414534
53MP0008004_abnormal_stomach_pH1.28172532
54MP0003690_abnormal_glial_cell1.27067823
55MP0009764_decreased_sensitivity_to1.26564866
56MP0001533_abnormal_skeleton_physiology1.17487761
57MP0003172_abnormal_lysosome_physiology1.16812692
58MP0000703_abnormal_thymus_morphology1.16430160
59MP0009278_abnormal_bone_marrow1.12006148
60MP0002139_abnormal_hepatobiliary_system1.06196849
61MP0003300_gastrointestinal_ulcer1.05390624
62MP0003828_pulmonary_edema1.05337149
63MP0000343_altered_response_to1.02878065
64MP0004883_abnormal_blood_vessel1.02782274
65MP0002876_abnormal_thyroid_physiology1.02637229
66MP0002933_joint_inflammation1.02490523
67MP0002095_abnormal_skin_pigmentation1.01672367
68MP0000015_abnormal_ear_pigmentation0.98779749
69MP0010094_abnormal_chromosome_stability0.97144187
70MP0002019_abnormal_tumor_incidence0.94856916
71MP0000858_altered_metastatic_potential0.92296288
72MP0005167_abnormal_blood-brain_barrier0.91985733
73MP0000920_abnormal_myelination0.90665740
74MP0001986_abnormal_taste_sensitivity0.90524006
75MP0003943_abnormal_hepatobiliary_system0.90358748
76MP0010307_abnormal_tumor_latency0.89858812
77MP0005164_abnormal_response_to0.89729674
78MP0001851_eye_inflammation0.88057048
79MP0008260_abnormal_autophagy0.85565132
80MP0002277_abnormal_respiratory_mucosa0.85137746
81MP0003075_altered_response_to0.84482071
82MP0009763_increased_sensitivity_to0.83578567
83MP0005390_skeleton_phenotype0.80682531
84MP0003191_abnormal_cellular_cholesterol0.77884122
85MP0001348_abnormal_lacrimal_gland0.77240650
86MP0005165_increased_susceptibility_to0.76657178
87MP0005584_abnormal_enzyme/coenzyme_acti0.75101482
88MP0008057_abnormal_DNA_replication0.74003990
89MP0001542_abnormal_bone_strength0.71901142
90MP0003795_abnormal_bone_structure0.71513162
91MP0005084_abnormal_gallbladder_morpholo0.70794699
92MP0002138_abnormal_hepatobiliary_system0.69955417
93MP0000681_abnormal_thyroid_gland0.69222690
94MP0003186_abnormal_redox_activity0.67663250
95MP0005166_decreased_susceptibility_to0.67568245
96MP0003448_altered_tumor_morphology0.67332920
97MP0001663_abnormal_digestive_system0.66171936
98MP0001879_abnormal_lymphatic_vessel0.66121403
99MP0005319_abnormal_enzyme/_coenzyme0.65790816
100MP0004147_increased_porphyrin_level0.65470288
101MP0002132_abnormal_respiratory_system0.65360808
102MP0008058_abnormal_DNA_repair0.65045080
103MP0009765_abnormal_xenobiotic_induced0.64926892
104MP0009379_abnormal_foot_pigmentation0.64726239
105MP0000249_abnormal_blood_vessel0.63628863
106MP0002693_abnormal_pancreas_physiology0.62479059
107MP0009840_abnormal_foam_cell0.62295157
108MP0003453_abnormal_keratinocyte_physiol0.62289340
109MP0003656_abnormal_erythrocyte_physiolo0.62091919
110MP0002332_abnormal_exercise_endurance0.60933968
111MP0003183_abnormal_peptide_metabolism0.59244115
112MP0003693_abnormal_embryo_hatching0.59236615
113MP0005647_abnormal_sex_gland0.58698214
114MP0000598_abnormal_liver_morphology0.57793831
115MP0008007_abnormal_cellular_replicative0.57605613
116MP0008874_decreased_physiological_sensi0.56983056
117MP0000569_abnormal_digit_pigmentation0.56954541
118MP0005365_abnormal_bile_salt0.56252578
119MP0001764_abnormal_homeostasis0.53551367
120MP0005535_abnormal_body_temperature0.52943320
121MP0000477_abnormal_intestine_morphology0.52850085
122MP0002136_abnormal_kidney_physiology0.52266421
123MP0002928_abnormal_bile_duct0.52195319
124MP0000371_diluted_coat_color0.52173220
125MP0002998_abnormal_bone_remodeling0.52058052
126MP0000609_abnormal_liver_physiology0.48121237

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.14321620
2Abnormality of liposaccharide metabolism (HP:0010968)5.61587847
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.61587847
4Abnormality of glycolipid metabolism (HP:0010969)5.61587847
5Recurrent abscess formation (HP:0002722)5.59831342
6Recurrent bacterial skin infections (HP:0005406)5.44384692
7Recurrent bronchitis (HP:0002837)5.21627875
8Cellulitis (HP:0100658)4.64145552
9Chronic otitis media (HP:0000389)4.58033645
10Eczematoid dermatitis (HP:0000976)4.52619019
11Abnormality of B cell number (HP:0010975)4.39208919
12B lymphocytopenia (HP:0010976)4.39208919
13Systemic lupus erythematosus (HP:0002725)4.33029095
14IgM deficiency (HP:0002850)4.22396503
15Recurrent viral infections (HP:0004429)4.18412458
16Colitis (HP:0002583)4.15610479
17Gastrointestinal stroma tumor (HP:0100723)4.02551154
18Elevated erythrocyte sedimentation rate (HP:0003565)3.97424468
19Meningitis (HP:0001287)3.95061249
20Thrombocytosis (HP:0001894)3.89879844
21Stomatitis (HP:0010280)3.84330410
22Myositis (HP:0100614)3.83788374
23Recurrent skin infections (HP:0001581)3.67436224
24Recurrent pneumonia (HP:0006532)3.66011091
25Inflammation of the large intestine (HP:0002037)3.65783572
26Dysostosis multiplex (HP:0000943)3.59585095
27Mediastinal lymphadenopathy (HP:0100721)3.55451189
28Amyloidosis (HP:0011034)3.53465673
29Recurrent sinusitis (HP:0011108)3.51435345
30Recurrent gram-negative bacterial infections (HP:0005420)3.47977888
31Gastrointestinal inflammation (HP:0004386)3.44976670
32Vasculitis (HP:0002633)3.40866630
33Recurrent fungal infections (HP:0002841)3.35643958
34Recurrent lower respiratory tract infections (HP:0002783)3.24444141
35Abnormality of macrophages (HP:0004311)3.22091603
36Spontaneous hematomas (HP:0007420)3.21213306
37Panhypogammaglobulinemia (HP:0003139)3.20243544
38Prolonged bleeding time (HP:0003010)3.03568976
39Osteomyelitis (HP:0002754)3.02910205
40Mutism (HP:0002300)3.02563029
41Petechiae (HP:0000967)3.02552362
42Increased neuronal autofluorescent lipopigment (HP:0002074)3.01198071
43Bronchitis (HP:0012387)2.99150823
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.95753119
45Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.94019611
46Chronic obstructive pulmonary disease (HP:0006510)2.91874357
47Obstructive lung disease (HP:0006536)2.91874357
48Interstitial pulmonary disease (HP:0006530)2.89668065
49Verrucae (HP:0200043)2.82777753
50Papilloma (HP:0012740)2.82777753
51Chronic sinusitis (HP:0011109)2.79863397
52Abnormality of T cell physiology (HP:0011840)2.79047959
53Gingivitis (HP:0000230)2.77401409
54Recurrent cutaneous fungal infections (HP:0011370)2.77291064
55Chronic mucocutaneous candidiasis (HP:0002728)2.77291064
56Arterial thrombosis (HP:0004420)2.76032281
57Increased cerebral lipofuscin (HP:0011813)2.73983069
58Lymphopenia (HP:0001888)2.67702049
59Aplastic anemia (HP:0001915)2.66763359
60Abnormality of polysaccharide metabolism (HP:0011012)2.66011526
61Abnormality of glycosaminoglycan metabolism (HP:0004371)2.66011526
62Abnormality of mucopolysaccharide metabolism (HP:0011020)2.66011526
63Poikiloderma (HP:0001029)2.64979157
64Gastrointestinal infarctions (HP:0005244)2.64268642
65Acute lymphatic leukemia (HP:0006721)2.61204158
66Optic neuritis (HP:0100653)2.60600397
67Retrobulbar optic neuritis (HP:0100654)2.60600397
68Emphysema (HP:0002097)2.60447960
69Chest pain (HP:0100749)2.58818610
70Abnormality of cells of the lymphoid lineage (HP:0012140)2.57807802
71Orchitis (HP:0100796)2.56356599
72Loss of speech (HP:0002371)2.55988912
73Abnormality of T cells (HP:0002843)2.55907191
74Nasal polyposis (HP:0100582)2.54133308
75Keratoconjunctivitis (HP:0001096)2.53011077
76IgG deficiency (HP:0004315)2.52035836
77Mucopolysacchariduria (HP:0008155)2.50544620
78Urinary glycosaminoglycan excretion (HP:0003541)2.50544620
79Hepatosplenomegaly (HP:0001433)2.48376018
80Epistaxis (HP:0000421)2.47862946
81Glomerulonephritis (HP:0000099)2.47348343
82Axonal loss (HP:0003447)2.46385553
83Vacuolated lymphocytes (HP:0001922)2.45988771
84Increased serum ferritin (HP:0003281)2.45948513
85Impaired platelet aggregation (HP:0003540)2.45045955
86Abnormal platelet function (HP:0011869)2.45045955
87Increased IgE level (HP:0003212)2.41537864
88Agnosia (HP:0010524)2.40542585
89Gangrene (HP:0100758)2.39916011
90Pulmonary embolism (HP:0002204)2.36640324
91Abnormality of the prostate (HP:0008775)2.36575381
92Encephalitis (HP:0002383)2.34742009
93Chronic diarrhea (HP:0002028)2.34571196
94Abnormality of the pleura (HP:0002103)2.33943945
95Skin rash (HP:0000988)2.33695453
96Abnormality of the nasal mucosa (HP:0000433)2.33563527
97Polyneuropathy (HP:0001271)2.32429936
98Reduced antithrombin III activity (HP:0001976)2.30951222
99Lymphoma (HP:0002665)2.29861687
100Abnormality of the vasculature of the conjunctiva (HP:0008054)2.29697470
101Cutaneous melanoma (HP:0012056)2.29624803
102Entropion (HP:0000621)2.28685321
103IgA deficiency (HP:0002720)2.27780211
104Autoimmune hemolytic anemia (HP:0001890)2.27685915
105Autoimmune thrombocytopenia (HP:0001973)2.24845667
106Urticaria (HP:0001025)2.23427252
107Sepsis (HP:0100806)2.23293978
108Pulmonary infiltrates (HP:0002113)2.22353819
109Neutropenia (HP:0001875)2.21467341
110Diminished motivation (HP:0000745)2.19314922
111Leukocytosis (HP:0001974)2.15378306
112Gingival bleeding (HP:0000225)2.15325641
113Pustule (HP:0200039)2.14644834
114Increased IgM level (HP:0003496)2.13925445
115Abnormality of iron homeostasis (HP:0011031)2.13390284
116Abnormality of T cell number (HP:0011839)2.12553596
117Restrictive lung disease (HP:0002091)2.11228549
118Papilledema (HP:0001085)2.10364898
119Apathy (HP:0000741)2.09328263
120Exertional dyspnea (HP:0002875)2.09033772
121Progressive neurologic deterioration (HP:0002344)2.08355685
122Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.08325521
123Upper motor neuron abnormality (HP:0002127)2.07644487
124Inappropriate behavior (HP:0000719)2.07290238
125Amaurosis fugax (HP:0100576)2.06932335
126Hypergammaglobulinemia (HP:0010702)2.05753397
127Memory impairment (HP:0002354)2.04180763
128T lymphocytopenia (HP:0005403)2.03357265
129Glomerulopathy (HP:0100820)2.03182547
130Leukopenia (HP:0001882)2.02378022
131Skin ulcer (HP:0200042)2.01910408
132Microcytic anemia (HP:0001935)2.01346908
133Anorexia (HP:0002039)1.99867058
134Hematochezia (HP:0002573)1.98705465
135Abnormality of complement system (HP:0005339)1.98560911
136Purpura (HP:0000979)1.97946471
137Thoracic kyphosis (HP:0002942)1.96520616
138Complement deficiency (HP:0004431)1.96453056
139Vertigo (HP:0002321)1.96130758
140Keratoconjunctivitis sicca (HP:0001097)1.95713721
141Basal ganglia calcification (HP:0002135)1.93100876
142Disinhibition (HP:0000734)1.91621892
143Premature loss of primary teeth (HP:0006323)1.91540394
144Recurrent otitis media (HP:0000403)1.91414510
145Neuronal loss in central nervous system (HP:0002529)1.91387125
146Hemoptysis (HP:0002105)1.89845944
147Abnormal number of erythroid precursors (HP:0012131)1.89529122

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K134.49504520
2MAP4K14.16101428
3MAP3K143.63578594
4KIT3.20777051
5PKN22.99800081
6BMPR22.87476455
7TRIB32.78778463
8TBK12.66478401
9TNIK2.61687449
10CSF1R2.54386353
11IRAK42.44810874
12BLK2.22321990
13RIPK42.15294028
14TYK22.13913703
15TEC2.07730111
16SYK2.07508956
17BTK2.05884569
18NME22.01187702
19ERN11.91286484
20FGR1.83546605
21FLT31.78136874
22STK41.77739052
23IKBKB1.77269137
24SIK31.66973524
25LRRK21.60459998
26JAK31.59929294
27SRPK11.59300308
28PRPF4B1.58725700
29MAP3K111.56655050
30IKBKE1.55262178
31MATK1.53884552
32TNK21.51035493
33MAP3K31.50773958
34TAOK31.44205711
35ZAP701.41225726
36TAOK21.39258968
37LYN1.32717932
38TAOK11.32619819
39TGFBR21.28801786
40MAP3K121.25886578
41FES1.24754420
42STK161.23903939
43PIM21.23772506
44MAP2K31.17521907
45GRK61.15139259
46MOS1.12393999
47CHUK1.11972310
48CDK61.09300696
49CDK41.03409945
50SIK20.99643810
51LCK0.97998096
52CLK10.97952025
53TESK20.96313932
54CDK190.95394547
55TXK0.94168531
56JAK10.93444231
57MAP3K10.92362154
58CAMKK20.91308337
59IRAK30.87475960
60MAP2K70.85813405
61PIM10.84682981
62PIK3CG0.82970085
63HCK0.81805745
64CSK0.81428086
65ABL20.81275949
66STK100.80167914
67STK380.79659889
68ILK0.78585169
69EIF2AK30.76294163
70ITK0.75577352
71NUAK10.74804727
72CDC42BPA0.74315870
73MKNK20.69553621
74PRKCQ0.67056354
75STK240.65946474
76PDPK10.64220820
77CAMKK10.63929906
78NEK90.61826548
79MUSK0.61605805
80BCKDK0.60561802
81MAPK120.59608357
82MAP2K60.59071081
83MAP3K50.58827465
84MAPK70.58670059
85IRAK20.57669519
86ADRBK20.56315461
87GRK10.56075150
88YES10.54597197
89DDR20.54558628
90ACVR1B0.54392365
91RPS6KA40.54329765
92RAF10.53976048
93MKNK10.53708746
94FYN0.52894275
95VRK10.52009762
96IRAK10.51622232
97NLK0.49267150
98TIE10.47748510
99ARAF0.47546232
100DYRK30.46336506
101MAPK40.44471567
102MAP3K70.44300633
103CHEK20.40127109
104MAP3K100.40076479
105TRPM70.39887916
106EGFR0.39118268
107KDR0.38479112
108DAPK30.38446762
109MARK20.38063173
110MAP3K60.37893003
111RPS6KL10.37849372
112RPS6KC10.37849372
113EEF2K0.37755453
114MAPKAPK20.36546259
115PRKCD0.35028930
116EIF2AK20.34656175
117HIPK20.34656095
118PDK10.33914382
119ABL10.32754885
120SIK10.32185728
121CCNB10.31486727
122RPS6KA60.31002461
123RIPK10.30871914
124JAK20.30826098
125PAK40.30480499
126TGFBR10.30366568
127MARK30.30024200
128KSR20.29898707
129EPHB10.29856406
130MST40.29448184
131DAPK20.28520283
132CAMK1D0.28274834
133ATR0.27514641
134IGF1R0.26601426
135MYLK0.26572341
136PTK60.25819051
137PRKG20.23897489
138FGFR40.23656743
139GRK70.22551883

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.59436607
2B cell receptor signaling pathway_Homo sapiens_hsa046623.46580805
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.20030351
4Leishmaniasis_Homo sapiens_hsa051402.71331911
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.40913273
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.34995019
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.28882734
8Antigen processing and presentation_Homo sapiens_hsa046122.18097379
9Osteoclast differentiation_Homo sapiens_hsa043802.15751151
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.12357226
11Allograft rejection_Homo sapiens_hsa053302.09954162
12Measles_Homo sapiens_hsa051621.94879297
13Hematopoietic cell lineage_Homo sapiens_hsa046401.94038852
14Herpes simplex infection_Homo sapiens_hsa051681.89975654
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.86585263
16DNA replication_Homo sapiens_hsa030301.84293704
17Protein export_Homo sapiens_hsa030601.78773662
18Pertussis_Homo sapiens_hsa051331.77269278
19Asthma_Homo sapiens_hsa053101.76247746
20Non-homologous end-joining_Homo sapiens_hsa034501.68373822
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.66594239
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61169631
23Ribosome_Homo sapiens_hsa030101.59299476
24Influenza A_Homo sapiens_hsa051641.56116394
25Other glycan degradation_Homo sapiens_hsa005111.54623965
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.54591689
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.53659321
28Tuberculosis_Homo sapiens_hsa051521.52373277
29Toxoplasmosis_Homo sapiens_hsa051451.52281107
30Base excision repair_Homo sapiens_hsa034101.51344058
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49628355
32Graft-versus-host disease_Homo sapiens_hsa053321.48763609
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.47606165
34Legionellosis_Homo sapiens_hsa051341.45396811
35Shigellosis_Homo sapiens_hsa051311.43780880
36Acute myeloid leukemia_Homo sapiens_hsa052211.42045856
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38552913
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.38459387
39Mismatch repair_Homo sapiens_hsa034301.37365523
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.31999712
41Malaria_Homo sapiens_hsa051441.30957912
42Staphylococcus aureus infection_Homo sapiens_hsa051501.29090354
43Platelet activation_Homo sapiens_hsa046111.28617262
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25874702
45Homologous recombination_Homo sapiens_hsa034401.24016481
46Chemokine signaling pathway_Homo sapiens_hsa040621.22982626
47Hepatitis B_Homo sapiens_hsa051611.19383052
48Apoptosis_Homo sapiens_hsa042101.18627246
49TNF signaling pathway_Homo sapiens_hsa046681.18107004
50African trypanosomiasis_Homo sapiens_hsa051431.14658387
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12277934
52T cell receptor signaling pathway_Homo sapiens_hsa046601.09914265
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03454694
54Viral myocarditis_Homo sapiens_hsa054160.96144492
55Collecting duct acid secretion_Homo sapiens_hsa049660.94608486
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94119256
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.92610038
58Hepatitis C_Homo sapiens_hsa051600.90276498
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90203300
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90175063
61Autoimmune thyroid disease_Homo sapiens_hsa053200.88989012
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85534187
63Salmonella infection_Homo sapiens_hsa051320.83117204
64N-Glycan biosynthesis_Homo sapiens_hsa005100.83101931
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.79233135
66Lysosome_Homo sapiens_hsa041420.78747078
67Type I diabetes mellitus_Homo sapiens_hsa049400.77974341
68Epstein-Barr virus infection_Homo sapiens_hsa051690.76492670
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73553844
70Pancreatic cancer_Homo sapiens_hsa052120.69899612
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67306474
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66511764
73Nucleotide excision repair_Homo sapiens_hsa034200.66262333
74Chronic myeloid leukemia_Homo sapiens_hsa052200.64227083
75Rheumatoid arthritis_Homo sapiens_hsa053230.63641274
76Caffeine metabolism_Homo sapiens_hsa002320.59338556
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57644021
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57447259
79Viral carcinogenesis_Homo sapiens_hsa052030.57311072
80Prolactin signaling pathway_Homo sapiens_hsa049170.53086042
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52134411
82Non-small cell lung cancer_Homo sapiens_hsa052230.51901367
83Amoebiasis_Homo sapiens_hsa051460.49459462
84Small cell lung cancer_Homo sapiens_hsa052220.49145224
85HTLV-I infection_Homo sapiens_hsa051660.48773508
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44921286
87Phagosome_Homo sapiens_hsa041450.44763255
88Pyrimidine metabolism_Homo sapiens_hsa002400.42929633
89p53 signaling pathway_Homo sapiens_hsa041150.41918657
90Fanconi anemia pathway_Homo sapiens_hsa034600.41202021
91Regulation of autophagy_Homo sapiens_hsa041400.39792083
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39572201
93Spliceosome_Homo sapiens_hsa030400.39059217
94Systemic lupus erythematosus_Homo sapiens_hsa053220.38560186
95Vibrio cholerae infection_Homo sapiens_hsa051100.36463234
96Endocytosis_Homo sapiens_hsa041440.36003934
97Bladder cancer_Homo sapiens_hsa052190.35174576
98Prion diseases_Homo sapiens_hsa050200.33152837
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31775416
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.30094409
101Colorectal cancer_Homo sapiens_hsa052100.29157279
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28288209
103Sphingolipid metabolism_Homo sapiens_hsa006000.24738863
104Galactose metabolism_Homo sapiens_hsa000520.24381807
105Arachidonic acid metabolism_Homo sapiens_hsa005900.24015937
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23365140
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22929726
108VEGF signaling pathway_Homo sapiens_hsa043700.22007780
109RNA degradation_Homo sapiens_hsa030180.20928662
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.20399023
111HIF-1 signaling pathway_Homo sapiens_hsa040660.20035955
112Oxidative phosphorylation_Homo sapiens_hsa001900.18991306
113Cell cycle_Homo sapiens_hsa041100.18287659
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.18105870
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.16934467
116Complement and coagulation cascades_Homo sapiens_hsa046100.16530704
117Sulfur metabolism_Homo sapiens_hsa009200.13692807
118Renal cell carcinoma_Homo sapiens_hsa052110.12956410
119Ether lipid metabolism_Homo sapiens_hsa005650.11876261
120Renin-angiotensin system_Homo sapiens_hsa046140.11563936
121Mineral absorption_Homo sapiens_hsa049780.11516060
122GnRH signaling pathway_Homo sapiens_hsa049120.08938558
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.06099536
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.03979414

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