RNASE7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein has broad-spectrum antimicrobial activity against bacteria and fungi. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte differentiation (GO:0030216)9.92815479
2epidermal cell differentiation (GO:0009913)8.62329571
3multicellular organismal water homeostasis (GO:0050891)8.45362488
4desmosome organization (GO:0002934)8.10841122
5positive regulation of interleukin-8 secretion (GO:2000484)7.98943858
6regulation of transforming growth factor beta1 production (GO:0032908)7.80883396
7keratinocyte proliferation (GO:0043616)7.64265546
8hair cycle (GO:0042633)7.37862223
9molting cycle (GO:0042303)7.37862223
10peptide cross-linking (GO:0018149)7.21206802
11positive regulation of glomerulus development (GO:0090193)7.14971196
12water homeostasis (GO:0030104)7.08817278
13positive regulation of humoral immune response (GO:0002922)6.88164651
14epidermis development (GO:0008544)6.84272500
15positive regulation of p38MAPK cascade (GO:1900745)6.63547253
16long-chain fatty acid biosynthetic process (GO:0042759)6.40958870
17regulation of cell proliferation involved in kidney development (GO:1901722)5.93934202
18positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)5.90221738
19regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)5.90221738
20defense response to fungus (GO:0050832)5.68681002
21regulation of cellular amide metabolic process (GO:0034248)5.60076737
22lipoxygenase pathway (GO:0019372)5.55725179
23negative regulation of interleukin-17 production (GO:0032700)5.45701808
24skin morphogenesis (GO:0043589)5.44414345
25regulation of interleukin-8 secretion (GO:2000482)5.43598400
26positive regulation of T-helper 1 type immune response (GO:0002827)5.10763882
27linoleic acid metabolic process (GO:0043651)5.07201576
28bundle of His cell to Purkinje myocyte communication (GO:0086069)5.06617529
29regulation of p38MAPK cascade (GO:1900744)4.85827271
30surfactant homeostasis (GO:0043129)4.85017852
31ectoderm development (GO:0007398)4.81364857
32hemidesmosome assembly (GO:0031581)4.76153819
33detection of bacterium (GO:0016045)4.57804566
34regulation of glomerulus development (GO:0090192)4.56083860
35chemical homeostasis within a tissue (GO:0048875)4.49699460
36negative regulation of interferon-gamma production (GO:0032689)4.39010021
37positive regulation of transforming growth factor beta production (GO:0071636)4.30638703
38positive regulation of epidermis development (GO:0045684)4.28110926
39intermediate filament cytoskeleton organization (GO:0045104)4.24245389
40activation of MAPKKK activity (GO:0000185)4.20056175
41intermediate filament organization (GO:0045109)4.15605041
42detection of other organism (GO:0098543)4.15594944
43intermediate filament-based process (GO:0045103)4.10361554
44fatty acid elongation (GO:0030497)4.04299642
45phosphatidylserine acyl-chain remodeling (GO:0036150)4.01046638
46positive regulation of cholesterol efflux (GO:0010875)3.92767131
47positive regulation of response to biotic stimulus (GO:0002833)3.92352187
48response to fungus (GO:0009620)3.92264123
49natural killer cell activation involved in immune response (GO:0002323)3.91028825
50regulation of MHC class I biosynthetic process (GO:0045343)3.86277822
51phosphatidylinositol acyl-chain remodeling (GO:0036149)3.80386265
52nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.74662307
53dendritic cell migration (GO:0036336)3.67217533
54phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.62365479
55regulation of T-helper 1 type immune response (GO:0002825)3.61883541
56positive regulation of cholesterol transport (GO:0032376)3.57800985
57positive regulation of sterol transport (GO:0032373)3.57800985
58regulation of natural killer cell differentiation (GO:0032823)3.53379214
59phospholipid efflux (GO:0033700)3.53248656
60positive regulation of keratinocyte differentiation (GO:0045618)3.51086058
61hair cell differentiation (GO:0035315)3.49233122
62regulation of hair cycle (GO:0042634)3.45803010
63phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.44777031
64positive regulation of epidermal cell differentiation (GO:0045606)3.43283764
65* defense response to Gram-negative bacterium (GO:0050829)3.40704283
66positive regulation of meiotic cell cycle (GO:0051446)3.39975837
67keratinocyte development (GO:0003334)3.37276469
68phosphatidylcholine acyl-chain remodeling (GO:0036151)3.28501716
69regulation of transforming growth factor beta production (GO:0071634)3.19334718
70regulation of axon regeneration (GO:0048679)3.16480302
71regulation of neuron projection regeneration (GO:0070570)3.16480302
72ceramide biosynthetic process (GO:0046513)3.16140239
73negative regulation of meiotic cell cycle (GO:0051447)3.14288566
74epithelium development (GO:0060429)3.10093114
75branching involved in labyrinthine layer morphogenesis (GO:0060670)3.08261587
76early endosome to late endosome transport (GO:0045022)3.05456749
77cellular response to arsenic-containing substance (GO:0071243)3.05340697
78negative regulation of keratinocyte proliferation (GO:0010839)3.00697865
79keratinization (GO:0031424)28.8178718
80regulation of epidermis development (GO:0045682)2.96850256
81regulation of collagen biosynthetic process (GO:0032965)2.95733801
82positive regulation of interleukin-6 production (GO:0032755)2.93623053
83regulation of interleukin-17 production (GO:0032660)2.89892688
84regulation of ruffle assembly (GO:1900027)2.78856213
85establishment of planar polarity (GO:0001736)2.74126943
86establishment of tissue polarity (GO:0007164)2.74126943
87positive regulation of collagen biosynthetic process (GO:0032967)2.72934402
88bile acid and bile salt transport (GO:0015721)2.71224638
89regulation of keratinocyte differentiation (GO:0045616)2.69987685
90regulation of cholesterol homeostasis (GO:2000188)2.69150656
91cellular protein complex localization (GO:0034629)2.66171306
92hypotonic response (GO:0006971)2.64191584
93gap junction assembly (GO:0016264)2.59332107
94positive regulation of collagen metabolic process (GO:0010714)2.57593295
95negative regulation of vascular permeability (GO:0043116)2.55793950
96regulation of interleukin-6 production (GO:0032675)2.54237016
97C21-steroid hormone biosynthetic process (GO:0006700)2.52446377
98establishment of skin barrier (GO:0061436)15.2952985
99regulation of water loss via skin (GO:0033561)13.2586236
100positive regulation of cellular amide metabolic process (GO:0034250)10.9505108

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse7.65329024
2* P63_26484246_Chip-Seq_KERATINOCYTES_Human4.44537147
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.18333591
4SMAD2_18955504_ChIP-ChIP_HaCaT_Human3.68710157
5SMAD3_18955504_ChIP-ChIP_HaCaT_Human3.68710157
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.67841891
7FOXO3_23340844_ChIP-Seq_DLD1_Human2.58215633
8HIF1A_21447827_ChIP-Seq_MCF-7_Human2.52147435
9SOX9_24532713_ChIP-Seq_HFSC_Mouse2.36587881
10* TP63_23658742_ChIP-Seq_EP156T_Human2.26141863
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.07257788
12GATA6_21074721_ChIP-Seq_CACO-2_Mouse2.01379601
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.00785352
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.00629533
15TP63_17297297_ChIP-ChIP_HaCaT_Human11.1124430
16ESR1_20079471_ChIP-ChIP_T-47D_Human1.93055747
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.92608772
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90329610
19ATF3_27146783_Chip-Seq_COLON_Human1.86012336
20RXR_22108803_ChIP-Seq_LS180_Human1.82374227
21FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.82126198
22ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.78798127
23JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.75046557
24KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.69119053
25TP63_22573176_ChIP-Seq_HFKS_Human1.69077275
26SOX2_20726797_ChIP-Seq_SW620_Human1.66353930
27JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64951049
28GATA6_21074721_ChIP-Seq_CACO-2_Human1.60324221
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58654935
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57891573
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54110180
32SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.52314633
33CJUN_26792858_Chip-Seq_BT549_Human1.39087524
34TCF4_18268006_ChIP-ChIP_LS174T_Human1.38894609
35EGR1_19032775_ChIP-ChIP_M12_Human1.36859146
36* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.35486512
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35036560
38UBF1/2_26484160_Chip-Seq_HMECs_Human1.30396752
39FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.29541940
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29114964
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26600217
42* GATA3_24758297_ChIP-Seq_MCF-7_Human1.26479696
43CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25751534
44ERG_20517297_ChIP-Seq_VCAP_Human1.25547953
45ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23955567
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21737999
47KLF5_25053715_ChIP-Seq_YYC3_Human1.21446095
48GATA4_25053715_ChIP-Seq_YYC3_Human1.18937132
49TP53_16413492_ChIP-PET_HCT116_Human1.18313848
50RUNX1_27514584_Chip-Seq_MCF-7_Human1.17203744
51* CTCF_27219007_Chip-Seq_Bcells_Human1.16864080
52* TP53_18474530_ChIP-ChIP_U2OS_Human1.11334798
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11113570
54CTCF_20526341_ChIP-Seq_ESCs_Human1.06362060
55CLOCK_20551151_ChIP-Seq_293T_Human1.04483701
56RACK7_27058665_Chip-Seq_MCF-7_Human1.03370740
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00064394
58P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.97908296
59HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97655260
60CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.97239132
61PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94814075
62P53_21459846_ChIP-Seq_SAOS-2_Human0.93079260
63CEBPB_22108803_ChIP-Seq_LS180_Human0.93025935
64MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.92443573
65GATA6_25053715_ChIP-Seq_YYC3_Human0.92088508
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91412904
67NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91412904
68FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87368278
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85667922
70YY1_22570637_ChIP-Seq_MALME-3M_Human0.85285344
71AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84154893
72* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82514212
73EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.81694613
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80692153
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80112289
76SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.79891864
77* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78166951
78FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.77074690
79EGR1_19374776_ChIP-ChIP_THP-1_Human0.75736860
80AHR_22903824_ChIP-Seq_MCF-7_Human0.75397445
81SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.75241280
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74463003
83E2F1_20622854_ChIP-Seq_HELA_Human0.73499604
84RBPJ_21746931_ChIP-Seq_IB4_Human0.73018156
85PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.72833613
86SMC4_20622854_ChIP-Seq_HELA_Human0.71210065
87FOXA1_25552417_ChIP-Seq_VCAP_Human0.69355800
88HNFA_21074721_ChIP-Seq_CACO-2_Human0.69282272
89SMAD3_21741376_ChIP-Seq_HESCs_Human0.69019032
90P300_27058665_Chip-Seq_ZR-75-30cells_Human0.68454878
91PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.63810573
92GATA3_21867929_ChIP-Seq_TH1_Mouse0.63732288
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.63298681
94FOXH1_21741376_ChIP-Seq_ESCs_Human0.60954451
95CTNNB1_20460455_ChIP-Seq_HCT116_Human0.59623746
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.59425518
97ELK3_25401928_ChIP-Seq_HUVEC_Human0.58801668
98NFIB_24661679_ChIP-Seq_LUNG_Mouse0.58676822
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.58633543
100HTT_18923047_ChIP-ChIP_STHdh_Human0.58391702

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier9.41216567
2MP0010234_abnormal_vibrissa_follicle8.26775851
3MP0005275_abnormal_skin_tensile5.83832999
4MP0000579_abnormal_nail_morphology5.82436656
5MP0005501_abnormal_skin_physiology5.34127965
6MP0003941_abnormal_skin_development4.90434790
7MP0010678_abnormal_skin_adnexa3.59355237
8MP0003191_abnormal_cellular_cholesterol3.16803591
9MP0003453_abnormal_keratinocyte_physiol3.01823445
10MP0001216_abnormal_epidermal_layer2.98459852
11MP0010771_integument_phenotype2.85453419
12MP0004381_abnormal_hair_follicle2.82368580
13MP0002098_abnormal_vibrissa_morphology2.72080211
14MP0002060_abnormal_skin_morphology2.49723489
15MP0004947_skin_inflammation2.48099900
16MP0000383_abnormal_hair_follicle2.36304227
17MP0000377_abnormal_hair_follicle2.19602763
18MP0004782_abnormal_surfactant_physiolog2.17599640
19MP0003950_abnormal_plasma_membrane2.15264847
20MP0000467_abnormal_esophagus_morphology2.13428408
21MP0000762_abnormal_tongue_morphology1.71205370
22MP0009931_abnormal_skin_appearance1.48917486
23MP0010352_gastrointestinal_tract_polyps1.33027231
24MP0000367_abnormal_coat/_hair1.32664198
25MP0003705_abnormal_hypodermis_morpholog1.27700883
26MP0003011_delayed_dark_adaptation1.26816015
27MP0000566_synostosis1.23855188
28MP0004264_abnormal_extraembryonic_tissu1.22590690
29MP0005409_darkened_coat_color1.21582492
30MP0001191_abnormal_skin_condition1.14743792
31MP0004885_abnormal_endolymph1.13597604
32MP0003878_abnormal_ear_physiology1.13577037
33MP0005377_hearing/vestibular/ear_phenot1.13577037
34MP0004272_abnormal_basement_membrane1.10412793
35MP0003566_abnormal_cell_adhesion1.07341856
36MP0004185_abnormal_adipocyte_glucose1.07116192
37MP0000427_abnormal_hair_cycle1.02492579
38MP0000647_abnormal_sebaceous_gland0.98072852
39MP0008004_abnormal_stomach_pH0.92497269
40MP0001784_abnormal_fluid_regulation0.84734839
41MP0003656_abnormal_erythrocyte_physiolo0.84314855
42MP0001188_hyperpigmentation0.80866565
43MP0001243_abnormal_dermal_layer0.80324507
44MP0004043_abnormal_pH_regulation0.77226008
45MP0005023_abnormal_wound_healing0.77052520
46MP0009053_abnormal_anal_canal0.74591462
47MP0001851_eye_inflammation0.71524812
48MP0000465_gastrointestinal_hemorrhage0.66025923
49MP0002234_abnormal_pharynx_morphology0.65492802
50MP0003221_abnormal_cardiomyocyte_apopto0.60866759
51MP0005375_adipose_tissue_phenotype0.52129327
52MP0001177_atelectasis0.50216961
53MP0001340_abnormal_eyelid_morphology0.46694733
54MP0002095_abnormal_skin_pigmentation0.46045179
55MP0003828_pulmonary_edema0.45584690
56MP0003755_abnormal_palate_morphology0.42455394
57MP0009840_abnormal_foam_cell0.41050198
58MP0002136_abnormal_kidney_physiology0.39759756
59MP0005666_abnormal_adipose_tissue0.38905285
60MP0000003_abnormal_adipose_tissue0.38072173
61MP0009333_abnormal_splenocyte_physiolog0.37460057
62MP0003315_abnormal_perineum_morphology0.35402691
63MP0009672_abnormal_birth_weight0.34700386
64MP0004197_abnormal_fetal_growth/weight/0.31782096
65MP0005075_abnormal_melanosome_morpholog0.30051528
66MP0008057_abnormal_DNA_replication0.29790415
67MP0005451_abnormal_body_composition0.29207424
68MP0000627_abnormal_mammary_gland0.28716746
69MP0002697_abnormal_eye_size0.28075713
70MP0002133_abnormal_respiratory_system0.27066346
71MP0005388_respiratory_system_phenotype0.27066346
72MP0001502_abnormal_circadian_rhythm0.26898570
73MP0008260_abnormal_autophagy0.23551843
74MP0002177_abnormal_outer_ear0.22379201
75MP0001756_abnormal_urination0.20767090
76MP0005248_abnormal_Harderian_gland0.20760662
77MP0005076_abnormal_cell_differentiation0.20608486
78MP0008995_early_reproductive_senescence0.20586796
79MP0002295_abnormal_pulmonary_circulatio0.19511867
80MP0000470_abnormal_stomach_morphology0.19011151
81MP0002138_abnormal_hepatobiliary_system0.18705097
82MP0003806_abnormal_nucleotide_metabolis0.16767211
83MP0001765_abnormal_ion_homeostasis0.16504244
84MP0009765_abnormal_xenobiotic_induced0.15266353
85MP0005193_abnormal_anterior_eye0.14892740
86MP0002111_abnormal_tail_morphology0.14828604
87MP0004510_myositis0.14706925
88MP0000432_abnormal_head_morphology0.14015224
89MP0003638_abnormal_response/metabolism_0.13273978
90MP0000678_abnormal_parathyroid_gland0.12017901
91MP0002971_abnormal_brown_adipose0.11313505
92MP0009780_abnormal_chondrocyte_physiolo0.10505124
93MP0001286_abnormal_eye_development0.09158958
94MP0005503_abnormal_tendon_morphology0.09136504
95MP0009115_abnormal_fat_cell0.08308377
96MP0008789_abnormal_olfactory_epithelium0.06914746
97MP0002092_abnormal_eye_morphology0.04765111
98MP0002081_perinatal_lethality0.04482622
99MP0010386_abnormal_urinary_bladder0.04293243
100MP0002069_abnormal_eating/drinking_beha0.04213872

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.85728811
2Congenital nonbullous ichthyosiform erythroderma (HP:0007479)9.66527663
3Congenital ichthyosiform erythroderma (HP:0007431)8.85216290
4Parakeratosis (HP:0001036)8.83821405
5Palmoplantar hyperkeratosis (HP:0000972)7.96771173
6Palmar hyperkeratosis (HP:0010765)7.56354031
7Plantar hyperkeratosis (HP:0007556)6.98696826
8Erythroderma (HP:0001019)6.97446178
9Oral leukoplakia (HP:0002745)6.85719638
10Onycholysis (HP:0001806)6.39014642
11Erythema (HP:0010783)6.23786573
12Thick nail (HP:0001805)6.20278218
13Corneal erosion (HP:0200020)4.94409654
14Ectropion (HP:0000656)4.78478375
15Pustule (HP:0200039)4.75278794
16Fragile nails (HP:0001808)4.69669702
17Hypotrichosis (HP:0001006)4.60250234
18Palmoplantar keratoderma (HP:0000982)4.39021450
19Nail dystrophy (HP:0008404)4.30719866
20Hypohidrosis (HP:0000966)4.23454370
21Alopecia of scalp (HP:0002293)4.21531930
22Lip pit (HP:0100267)4.04140970
23Follicular hyperkeratosis (HP:0007502)4.03110336
24Gangrene (HP:0100758)3.87841661
25Right ventricular cardiomyopathy (HP:0011663)3.58890995
26Sparse scalp hair (HP:0002209)3.57146938
27Pruritus (HP:0000989)3.22240955
28Abnormal blistering of the skin (HP:0008066)3.18115962
29Abnormality of the axillary hair (HP:0100134)3.17218814
30Abnormality of secondary sexual hair (HP:0009888)3.17218814
31Milia (HP:0001056)3.07832049
32Hyperhidrosis (HP:0000975)3.07505980
33Dehydration (HP:0001944)2.94733436
34Laryngomalacia (HP:0001601)2.91923967
35Abnormality of small intestinal villus morphology (HP:0011472)2.78043181
36Villous atrophy (HP:0011473)2.78043181
37Abnormality of the salivary glands (HP:0010286)2.77359665
38Natal tooth (HP:0000695)2.72183751
39Corneal dystrophy (HP:0001131)2.69721122
40Woolly hair (HP:0002224)2.67364418
41Furrowed tongue (HP:0000221)2.66274920
42Brittle hair (HP:0002299)2.64627053
43Hypergammaglobulinemia (HP:0010702)2.52780486
44Lack of skin elasticity (HP:0100679)2.52270849
45Absent eyelashes (HP:0000561)2.35441759
46Sparse eyelashes (HP:0000653)2.28318479
47Anonychia (HP:0001798)2.18254198
48Acanthosis nigricans (HP:0000956)2.13359068
49Advanced eruption of teeth (HP:0006288)2.09401021
50Eczematoid dermatitis (HP:0000976)2.05357474
51Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.02047539
52Urticaria (HP:0001025)2.02007156
53Abnormality of nail color (HP:0100643)14.2047095
54Absent hair (HP:0002298)1.98582867
55Distal lower limb muscle weakness (HP:0009053)1.97379078
56Dry skin (HP:0000958)1.94883834
57Carious teeth (HP:0000670)1.91079820
58Hypoplastic labia majora (HP:0000059)1.90280561
59Abnormality of placental membranes (HP:0011409)1.88658752
60Amniotic constriction ring (HP:0009775)1.88658752
61Dry hair (HP:0011359)1.88211550
62Verrucae (HP:0200043)1.84523703
63Papilloma (HP:0012740)1.84523703
64Popliteal pterygium (HP:0009756)1.83095251
65Blepharitis (HP:0000498)1.80787802
66Sepsis (HP:0100806)1.79282756
67Ridged nail (HP:0001807)1.78023146
68Autoamputation (HP:0001218)1.73357464
69Abnormality of the labia majora (HP:0012881)1.72111650
70Skin ulcer (HP:0200042)1.71077890
71Atrophic scars (HP:0001075)1.67438347
72Abnormality of the fingernails (HP:0001231)1.64825007
73Pili torti (HP:0003777)1.64361766
74Hyporeflexia of lower limbs (HP:0002600)1.63312996
75Abnormal hair laboratory examination (HP:0003328)1.61680755
76Curly hair (HP:0002212)1.59344897
77Conjunctival hamartoma (HP:0100780)1.57463177
78Malignant hyperthermia (HP:0002047)1.51305892
79Oligodontia (HP:0000677)1.49101172
80Epidermoid cyst (HP:0200040)1.45434512
81Premature ovarian failure (HP:0008209)1.44461465
82Multifactorial inheritance (HP:0001426)1.41659544
83Fine hair (HP:0002213)1.41227579
84Asthma (HP:0002099)1.37550233
85Selective tooth agenesis (HP:0001592)1.37100800
86Everted lower lip vermilion (HP:0000232)1.29386224
87Malnutrition (HP:0004395)1.28897857
88Hypoplasia of dental enamel (HP:0006297)1.26314276
89Melanocytic nevus (HP:0000995)1.25337985
90Labial hypoplasia (HP:0000066)1.23161376
91Paralysis (HP:0003470)1.22562008
92Hyperactive renin-angiotensin system (HP:0000841)1.19494003
93Pterygium (HP:0001059)1.16119707
94Emphysema (HP:0002097)1.14755714
95Hoarse voice (HP:0001609)1.14319277
96Split foot (HP:0001839)1.13957313
97Skin pits (HP:0100276)1.13722152
98Hypoplastic female external genitalia (HP:0012815)1.10913847
99Ankyloglossia (HP:0010296)1.10711066
100Fragile skin (HP:0001030)1.10370810

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.89958889
2STK243.85419281
3EPHA212.0585102
4DYRK31.99531647
5ABL21.91325756
6PIM21.84581814
7IRAK21.79292798
8WNK11.75931839
9MAP3K121.75063528
10STK38L1.70685250
11MST1R1.66216081
12IRAK41.64865414
13IRAK11.53031893
14AKT31.51491208
15TGFBR21.46123579
16MAP3K21.42277424
17TGFBR11.40339843
18MAP3K31.37656808
19MET1.35927369
20MAPK151.35115396
21MOS1.30230593
22IKBKE1.27898763
23LATS11.27090792
24PDGFRB1.26749732
25LATS21.24131611
26RIPK11.22649008
27SGK2231.21545489
28SGK4941.21545489
29FER1.14390570
30GRK71.12499972
31SGK21.08499540
32SGK31.03108862
33FGFR11.02887746
34MST40.96095293
35ADRBK10.91702895
36EPHB20.91005777
37STK30.89943933
38MAP3K10.86155264
39PTK20.83484151
40TBK10.81879688
41STK100.79890979
42TAOK10.79173041
43PKN10.76572628
44CDK120.73000747
45IKBKB0.69802149
46MTOR0.69333091
47MAP3K50.68559563
48TSSK60.67366378
49MAP2K10.65717643
50CDK60.62519796
51BMX0.61060438
52IRAK30.60934654
53MAP3K60.60537374
54NEK60.53489611
55ERBB30.53031714
56BCR0.47606207
57BRAF0.46959927
58EIF2AK30.44016406
59TAOK20.43392093
60TYRO30.43178179
61PAK20.42840586
62STK380.41965438
63CHUK0.41909989
64PDGFRA0.41778568
65PDK20.40980473
66TRPM70.40178128
67MARK20.40131703
68PRPF4B0.39329293
69MAPK40.37821538
70GRK50.37791283
71RPS6KA10.36453201
72ARAF0.31145660
73ABL10.30314159
74HCK0.26185006
75FGFR30.25595939
76MAPKAPK30.25217021
77KSR20.24741765
78DAPK30.22879749
79CAMK1D0.22832022
80RPS6KL10.22339705
81RPS6KC10.22339705
82GSK3A0.22208319
83PRKCE0.22012359
84EPHB10.21848807
85FLT30.21364163
86MAP3K140.20813779
87RPS6KB10.20435326
88MAPK70.18985287
89CSK0.18971221
90MAP2K60.18883355
91PIM10.18810409
92PRKCI0.18113446
93NTRK10.16688657
94SGK10.16653558
95BRD40.15309249
96RPS6KA60.15225084
97MARK30.12915216
98CAMK1G0.12480642
99EIF2AK20.12252147
100DYRK1B0.11782917

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005926.22314878
2Linoleic acid metabolism_Homo sapiens_hsa005914.87673098
3Ether lipid metabolism_Homo sapiens_hsa005653.29521484
4NOD-like receptor signaling pathway_Homo sapiens_hsa046213.20704002
5Arachidonic acid metabolism_Homo sapiens_hsa005903.05525987
6Sphingolipid metabolism_Homo sapiens_hsa006003.04617034
7Circadian rhythm_Homo sapiens_hsa047102.48844871
8p53 signaling pathway_Homo sapiens_hsa041152.06513949
9Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.90350694
10Fatty acid elongation_Homo sapiens_hsa000621.75291781
11GnRH signaling pathway_Homo sapiens_hsa049121.74014100
12Ovarian steroidogenesis_Homo sapiens_hsa049131.68634776
13Tight junction_Homo sapiens_hsa045301.56135386
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.55429478
15VEGF signaling pathway_Homo sapiens_hsa043701.50964170
16Long-term depression_Homo sapiens_hsa047301.49002427
17Glycerophospholipid metabolism_Homo sapiens_hsa005641.40741171
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30187034
19Dorso-ventral axis formation_Homo sapiens_hsa043201.27334403
20Vascular smooth muscle contraction_Homo sapiens_hsa042701.21944887
21ErbB signaling pathway_Homo sapiens_hsa040121.20695437
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19643636
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18250950
24Endocytosis_Homo sapiens_hsa041441.14366505
25Inositol phosphate metabolism_Homo sapiens_hsa005621.14151324
26Collecting duct acid secretion_Homo sapiens_hsa049661.11237211
27Adherens junction_Homo sapiens_hsa045201.10177838
28Amoebiasis_Homo sapiens_hsa051461.09885887
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09656219
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05260408
31ABC transporters_Homo sapiens_hsa020100.99647975
32Choline metabolism in cancer_Homo sapiens_hsa052310.98474412
33Serotonergic synapse_Homo sapiens_hsa047260.97885851
34Vibrio cholerae infection_Homo sapiens_hsa051100.93339579
35Fat digestion and absorption_Homo sapiens_hsa049750.90964004
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90637948
37FoxO signaling pathway_Homo sapiens_hsa040680.90511346
38Ras signaling pathway_Homo sapiens_hsa040140.89239313
39Bladder cancer_Homo sapiens_hsa052190.87182101
40Retinol metabolism_Homo sapiens_hsa008300.84157342
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83308506
42MAPK signaling pathway_Homo sapiens_hsa040100.80674497
43Hepatitis C_Homo sapiens_hsa051600.79552585
44Salivary secretion_Homo sapiens_hsa049700.77773948
45Jak-STAT signaling pathway_Homo sapiens_hsa046300.77282514
46Acute myeloid leukemia_Homo sapiens_hsa052210.74351991
47Mineral absorption_Homo sapiens_hsa049780.73239296
48Sphingolipid signaling pathway_Homo sapiens_hsa040710.72601676
49Renal cell carcinoma_Homo sapiens_hsa052110.68613071
50Hippo signaling pathway_Homo sapiens_hsa043900.68441387
51Salmonella infection_Homo sapiens_hsa051320.66192951
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65787476
53Toxoplasmosis_Homo sapiens_hsa051450.65366921
54Pancreatic secretion_Homo sapiens_hsa049720.65142215
55ECM-receptor interaction_Homo sapiens_hsa045120.63800930
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.63065287
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61243166
58Histidine metabolism_Homo sapiens_hsa003400.60675391
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60180478
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.59710127
61MicroRNAs in cancer_Homo sapiens_hsa052060.58304045
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56171672
63Shigellosis_Homo sapiens_hsa051310.55445379
64Influenza A_Homo sapiens_hsa051640.54820015
65Platelet activation_Homo sapiens_hsa046110.54499943
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51376770
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.50998367
68Estrogen signaling pathway_Homo sapiens_hsa049150.50945519
69Synaptic vesicle cycle_Homo sapiens_hsa047210.50131551
70Renin secretion_Homo sapiens_hsa049240.49035421
71TGF-beta signaling pathway_Homo sapiens_hsa043500.45967555
72Thyroid cancer_Homo sapiens_hsa052160.44865672
73Apoptosis_Homo sapiens_hsa042100.43633117
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42769750
75Phenylalanine metabolism_Homo sapiens_hsa003600.42482740
76Notch signaling pathway_Homo sapiens_hsa043300.42301210
77Pertussis_Homo sapiens_hsa051330.42200360
78TNF signaling pathway_Homo sapiens_hsa046680.41465226
79Oxytocin signaling pathway_Homo sapiens_hsa049210.41225426
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.40764769
81Axon guidance_Homo sapiens_hsa043600.40235076
82Glutamatergic synapse_Homo sapiens_hsa047240.39932989
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.39650974
84Phototransduction_Homo sapiens_hsa047440.39480171
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38679647
86Proteoglycans in cancer_Homo sapiens_hsa052050.37512623
87Melanogenesis_Homo sapiens_hsa049160.35848006
88Tuberculosis_Homo sapiens_hsa051520.35606167
89Prion diseases_Homo sapiens_hsa050200.35508161
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32665249
91Insulin signaling pathway_Homo sapiens_hsa049100.32330139
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32127606
93Glycerolipid metabolism_Homo sapiens_hsa005610.31488150
94Staphylococcus aureus infection_Homo sapiens_hsa051500.31439964
95Glioma_Homo sapiens_hsa052140.30971987
96Small cell lung cancer_Homo sapiens_hsa052220.30542274
97Rap1 signaling pathway_Homo sapiens_hsa040150.30028211
98PPAR signaling pathway_Homo sapiens_hsa033200.30018019
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27494129
100Chronic myeloid leukemia_Homo sapiens_hsa052200.26455790

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