ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of tolerance induction (GO:0002645)	9.43051525
2	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	8.82249792
3	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	8.82249792
4	kynurenine metabolic process (GO:0070189)	8.57248088
5	sperm capacitation (GO:0048240)	8.41692552
6	regulation of tolerance induction (GO:0002643)	8.17403394
7	antigen processing and presentation via MHC class Ib (GO:0002475)	8.09496486
8	regulation of clathrin-mediated endocytosis (GO:2000369)	7.37433454
9	antigen processing and presentation of endogenous antigen (GO:0019883)	7.31428404
10	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	7.06831210
11	regulation of chronic inflammatory response (GO:0002676)	6.79089545
12	indole-containing compound catabolic process (GO:0042436)	6.45639821
13	indolalkylamine catabolic process (GO:0046218)	6.45639821
14	tryptophan catabolic process (GO:0006569)	6.45639821
15	single fertilization (GO:0007338)	6.42029150
16	heterotypic cell-cell adhesion (GO:0034113)	6.28887576
17	tryptophan metabolic process (GO:0006568)	5.52350682
18	negative regulation of interleukin-10 production (GO:0032693)	5.47981257
19	positive regulation of type 2 immune response (GO:0002830)	5.47030249
20	negative regulation of receptor-mediated endocytosis (GO:0048261)	4.92014240
21	negative regulation of endopeptidase activity (GO:0010951)	4.87489593
22	sulfur amino acid catabolic process (GO:0000098)	4.78552199
23	negative regulation of peptidase activity (GO:0010466)	4.65860538
24	aromatic amino acid family catabolic process (GO:0009074)	4.56036060
25	complement activation, alternative pathway (GO:0006957)	4.47959261
26	benzene-containing compound metabolic process (GO:0042537)	4.44449924
27	fertilization (GO:0009566)	4.20023126
28	regulation of acrosome reaction (GO:0060046)	4.19025034
29	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.16792160
30	cellular biogenic amine catabolic process (GO:0042402)	4.09932432
31	amine catabolic process (GO:0009310)	4.09932432
32	fusion of sperm to egg plasma membrane (GO:0007342)	4.08495479
33	indolalkylamine metabolic process (GO:0006586)	3.98657566
34	negative regulation of interleukin-8 production (GO:0032717)	3.84249457
35	negative regulation of protein autophosphorylation (GO:0031953)	3.77690809
36	alpha-linolenic acid metabolic process (GO:0036109)	3.76096787
37	valine metabolic process (GO:0006573)	3.64081464
38	response to misfolded protein (GO:0051788)	3.63835468
39	low-density lipoprotein particle clearance (GO:0034383)	3.56248494
40	negative regulation of T cell apoptotic process (GO:0070233)	3.46914874
41	phospholipid homeostasis (GO:0055091)	3.46576814
42	epithelial cell morphogenesis (GO:0003382)	3.42734080
43	aromatic amino acid family metabolic process (GO:0009072)	3.42333922
44	digestion (GO:0007586)	3.38513070
45	positive regulation of antigen processing and presentation (GO:0002579)	3.37185349
46	reverse cholesterol transport (GO:0043691)	3.29869728
47	regulation of lipoprotein metabolic process (GO:0050746)	3.28633326
48	negative regulation of proteolysis (GO:0045861)	3.22148608
49	triglyceride catabolic process (GO:0019433)	3.18068751
50	macroautophagy (GO:0016236)	3.16081960
51	plasma membrane fusion (GO:0045026)	3.15077719
52	negative regulation of protein maturation (GO:1903318)	3.10076798
53	negative regulation of protein processing (GO:0010955)	3.10076798
54	defense response to bacterium (GO:0042742)	3.05696658
55	positive regulation of cell-cell adhesion (GO:0022409)	3.00747859
56	cysteine metabolic process (GO:0006534)	3.00586602
57	acylglycerol catabolic process (GO:0046464)	2.98404833
58	neutral lipid catabolic process (GO:0046461)	2.98404833
59	regulation of Cdc42 GTPase activity (GO:0043088)	2.98093085
60	L-serine transport (GO:0015825)	2.97252601
61	transepithelial transport (GO:0070633)	2.93096220
62	regulation of type 2 immune response (GO:0002828)	2.85658255
63	indole-containing compound metabolic process (GO:0042430)	2.83795671
64	negative regulation of hydrolase activity (GO:0051346)	2.80159397
65	positive regulation of cholesterol transport (GO:0032376)	2.77875163
66	positive regulation of sterol transport (GO:0032373)	2.77875163
67	Golgi transport vesicle coating (GO:0048200)	2.76178648
68	COPI coating of Golgi vesicle (GO:0048205)	2.76178648
69	ethanol oxidation (GO:0006069)	2.70820886
70	cellular sodium ion homeostasis (GO:0006883)	2.68372236
71	white fat cell differentiation (GO:0050872)	2.65822792
72	regulation of endopeptidase activity (GO:0052548)	2.64703892
73	response to nitrosative stress (GO:0051409)	2.64423941
74	response to bacterium (GO:0009617)	2.62815637
75	negative regulation of glycogen biosynthetic process (GO:0045719)	2.62485773
76	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.62132684
77	brown fat cell differentiation (GO:0050873)	2.58681667
78	high-density lipoprotein particle remodeling (GO:0034375)	2.58146878
79	negative regulation of endocytosis (GO:0045806)	2.57667910
80	regulation of antigen processing and presentation (GO:0002577)	2.56114948
81	serine transport (GO:0032329)	2.55753707
82	negative regulation of metanephros development (GO:0072217)	2.53302928
83	CDP-diacylglycerol biosynthetic process (GO:0016024)	2.52901903
84	regulation of peptidase activity (GO:0052547)	2.51800158
85	N-acetylneuraminate metabolic process (GO:0006054)	2.43296473
86	glycerolipid catabolic process (GO:0046503)	2.42535099
87	cellular modified amino acid catabolic process (GO:0042219)	2.42051277
88	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	2.41943618
89	oxaloacetate metabolic process (GO:0006107)	2.40558772
90	regulation of complement activation (GO:0030449)	2.39906024
91	cytolysis (GO:0019835)	2.39371740
92	regulation of cholesterol transport (GO:0032374)	2.33803703
93	regulation of sterol transport (GO:0032371)	2.33803703
94	negative regulation of glycogen metabolic process (GO:0070874)	2.32728172
95	CDP-diacylglycerol metabolic process (GO:0046341)	2.31982533
96	positive regulation of glomerulus development (GO:0090193)	2.31084117
97	nerve growth factor signaling pathway (GO:0038180)	2.29508784
98	seminiferous tubule development (GO:0072520)	19.0539366
99	regulation of T cell tolerance induction (GO:0002664)	10.9864967
100	production of molecular mediator involved in inflammatory response (GO:0002532)	10.7705117

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA1_22025678_ChIP-Seq_K562_Human	5.15699062
2	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.79661576
3	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	4.44718340
4	AR_21572438_ChIP-Seq_LNCaP_Human	3.41416968
5	IKZF1_21737484_ChIP-ChIP_HCT116_Human	3.29212544
6	ESR1_21235772_ChIP-Seq_MCF-7_Human	3.10299260
7	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.91602405
8	ZNF263_19887448_ChIP-Seq_K562_Human	2.90878221
9	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.41682336
10	CLOCK_20551151_ChIP-Seq_293T_Human	2.37240884
11	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.36054950
12	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.31317645
13	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.28832429
14	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.20539478
15	DNAJC2_21179169_ChIP-ChIP_NT2_Human	2.09880407
16	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	2.08069166
17	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.79608039
18	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.76534815
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.75949081
20	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.70319022
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.69007871
22	STAT1_17558387_ChIP-Seq_HELA_Human	1.62930947
23	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.56025404
24	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.51418311
25	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.50588801
26	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.48579786
27	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.47594528
28	FLI1_21867929_ChIP-Seq_CD8_Mouse	1.45671473
29	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.44339653
30	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.43118678
31	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.43058575
32	P68_20966046_ChIP-Seq_HELA_Human	1.42235029
33	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.40672775
34	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.40344224
35	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.39139344
36	LXR_22292898_ChIP-Seq_THP-1_Human	1.39054274
37	MYC_19915707_ChIP-ChIP_AK7_Human	1.38878722
38	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.35903469
39	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.35410720
40	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.35094259
41	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.35094259
42	VDR_24787735_ChIP-Seq_THP-1_Human	1.33574471
43	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.29991031
44	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.23914497
45	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.21582133
46	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.21309189
47	BCOR_27268052_Chip-Seq_Bcells_Human	1.18446591
48	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.17603172
49	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.15230697
50	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.13571079
51	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.13218222
52	SMC4_20622854_ChIP-Seq_HELA_Human	1.12899623
53	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12882631
54	* SMAD4_21741376_ChIP-Seq_HESCs_Human	1.11903176
55	SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.09066116
56	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.08182046
57	RACK7_27058665_Chip-Seq_MCF-7_Human	1.04887445
58	MYC_27129775_Chip-Seq_CORNEA_Mouse	1.04355325
59	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.04265971
60	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.04233496
61	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.03235678
62	OCT4_20526341_ChIP-Seq_ESCs_Human	1.02672093
63	SOX2_20726797_ChIP-Seq_SW620_Human	0.99325728
64	REST_19997604_ChIP-ChIP_NEURONS_Mouse	0.99005769
65	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.97887891
66	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.97826967
67	BCL6_27268052_Chip-Seq_Bcells_Human	0.97498256
68	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.97251768
69	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.96610185
70	ESRRB_18555785_Chip-Seq_ESCs_Mouse	0.96342308
71	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.95880587
72	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.94883865
73	* ELF1_20517297_ChIP-Seq_JURKAT_Human	0.94758344
74	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.93377613
75	E2F1_20622854_ChIP-Seq_HELA_Human	0.92831956
76	KDM2B_26808549_Chip-Seq_K562_Human	0.92627358
77	RAC3_21632823_ChIP-Seq_H3396_Human	0.91070322
78	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.89766239
79	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.88343541
80	CEBPB_22108803_ChIP-Seq_LS180_Human	0.88295166
81	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.86853703
82	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.86003892
83	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.85575907
84	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.84936954
85	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.84714692
86	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.84398434
87	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.83851000
88	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.83706952
89	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	0.82884885
90	GATA1_19941826_ChIP-Seq_K562_Human	0.81340341
91	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.80748127
92	IGF1R_20145208_ChIP-Seq_DFB_Human	0.80313448
93	KDM2B_26808549_Chip-Seq_REH_Human	0.80108447
94	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.78882696
95	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.78684135
96	HTT_18923047_ChIP-ChIP_STHdh_Human	0.78584284
97	SMAD4_21741376_ChIP-Seq_ESCs_Human	0.76883370
98	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.76817994
99	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.76755094
100	GATA3_21867929_ChIP-Seq_CD8_Mouse	0.75479253

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005058_abnormal_lysosome_morphology	5.05198984
2	MP0003195_calcinosis	4.61644935
3	MP0002139_abnormal_hepatobiliary_system	4.35495107
4	MP0002254_reproductive_system_inflammat	4.18747879
5	MP0003303_peritoneal_inflammation	4.01447477
6	MP0004043_abnormal_pH_regulation	3.70727434
7	MP0010234_abnormal_vibrissa_follicle	3.31574790
8	MP0005670_abnormal_white_adipose	2.58066151
9	MP0005410_abnormal_fertilization	2.51691472
10	MP0000003_abnormal_adipose_tissue	2.49834645
11	MP0010329_abnormal_lipoprotein_level	2.42065448
12	MP0004130_abnormal_muscle_cell	2.28596279
13	MP0005375_adipose_tissue_phenotype	2.25340711
14	MP0003329_amyloid_beta_deposits	2.16430783
15	MP0004185_abnormal_adipocyte_glucose	2.04348568
16	MP0005666_abnormal_adipose_tissue	2.02781914
17	MP0005365_abnormal_bile_salt	1.97935348
18	MP0003300_gastrointestinal_ulcer	1.93821553
19	MP0005360_urolithiasis	1.87327723
20	MP0003705_abnormal_hypodermis_morpholog	1.86363338
21	MP0001501_abnormal_sleep_pattern	1.80535770
22	MP0002837_dystrophic_cardiac_calcinosis	1.77285387
23	MP0008438_abnormal_cutaneous_collagen	1.74248578
24	MP0003566_abnormal_cell_adhesion	1.72534580
25	MP0002168_other_aberrant_phenotype	1.71619243
26	MP0003191_abnormal_cellular_cholesterol	1.60600639
27	MP0001765_abnormal_ion_homeostasis	1.59780698
28	MP0000604_amyloidosis	1.59565015
29	MP0009643_abnormal_urine_homeostasis	1.53150131
30	MP0002118_abnormal_lipid_homeostasis	1.51798458
31	MP0003690_abnormal_glial_cell	1.49820495
32	MP0005275_abnormal_skin_tensile	1.42390884
33	MP0002876_abnormal_thyroid_physiology	1.40249335
34	MP0001756_abnormal_urination	1.38720686
35	MP0004885_abnormal_endolymph	1.34390507
36	MP0004858_abnormal_nervous_system	1.32782686
37	MP0005332_abnormal_amino_acid	1.31279467
38	MP0001853_heart_inflammation	1.30636434
39	MP0003806_abnormal_nucleotide_metabolis	1.29841125
40	MP0005584_abnormal_enzyme/coenzyme_acti	1.25369635
41	MP0005085_abnormal_gallbladder_physiolo	1.25280712
42	MP0002796_impaired_skin_barrier	1.19907890
43	MP0005636_abnormal_mineral_homeostasis	1.12739893
44	MP0000534_abnormal_ureter_morphology	1.10721525
45	MP0002971_abnormal_brown_adipose	1.10247070
46	MP0009780_abnormal_chondrocyte_physiolo	1.10041549
47	MP0003075_altered_response_to	1.07401558
48	MP0005334_abnormal_fat_pad	1.05750680
49	MP0003252_abnormal_bile_duct	1.03758994
50	MP0000609_abnormal_liver_physiology	1.01381756
51	MP0001440_abnormal_grooming_behavior	0.96541054
52	MP0002136_abnormal_kidney_physiology	0.96485627
53	MP0000537_abnormal_urethra_morphology	0.96380236
54	MP0003879_abnormal_hair_cell	0.94319618
55	MP0002909_abnormal_adrenal_gland	0.91134866
56	MP0004272_abnormal_basement_membrane	0.89322800
57	MP0002138_abnormal_hepatobiliary_system	0.89196048
58	MP0005535_abnormal_body_temperature	0.86349926
59	MP0002896_abnormal_bone_mineralization	0.86270456
60	MP0008875_abnormal_xenobiotic_pharmacok	0.86217415
61	MP0002653_abnormal_ependyma_morphology	0.84731843
62	MP0009763_increased_sensitivity_to	0.83059834
63	MP0009115_abnormal_fat_cell	0.82269580
64	MP0003959_abnormal_lean_body	0.81696504
65	MP0000013_abnormal_adipose_tissue	0.79236880
66	MP0005319_abnormal_enzyme/_coenzyme	0.78591741
67	MP0005377_hearing/vestibular/ear_phenot	0.76942460
68	MP0003878_abnormal_ear_physiology	0.76942460
69	MP0001764_abnormal_homeostasis	0.76864889
70	MP0003698_abnormal_male_reproductive	0.74016309
71	MP0000751_myopathy	0.73959661
72	MP0001666_abnormal_nutrient_absorption	0.72647678
73	MP0004019_abnormal_vitamin_homeostasis	0.72554084
74	MP0003632_abnormal_nervous_system	0.68966487
75	MP0002970_abnormal_white_adipose	0.68838271
76	MP0002733_abnormal_thermal_nociception	0.68811861
77	MP0004264_abnormal_extraembryonic_tissu	0.68212230
78	MP0002089_abnormal_postnatal_growth/wei	0.68137920
79	MP0006138_congestive_heart_failure	0.67475560
80	MP0003656_abnormal_erythrocyte_physiolo	0.66922845
81	MP0004036_abnormal_muscle_relaxation	0.66762776
82	MP0000249_abnormal_blood_vessel	0.65870839
83	MP0002295_abnormal_pulmonary_circulatio	0.64741339
84	MP0009384_cardiac_valve_regurgitation	0.63518960
85	MP0004270_analgesia	0.63066757
86	MP0002933_joint_inflammation	0.63020393
87	MP0002078_abnormal_glucose_homeostasis	0.62906302
88	MP0003633_abnormal_nervous_system	0.61155735
89	MP0005164_abnormal_response_to	0.60167033
90	MP0004145_abnormal_muscle_electrophysio	0.59783695
91	MP0000920_abnormal_myelination	0.59780424
92	MP0001881_abnormal_mammary_gland	0.59770542
93	MP0008961_abnormal_basal_metabolism	0.59230907
94	MP0003045_fibrosis	0.59070708
95	MP0003631_nervous_system_phenotype	0.59068706
96	MP0004859_abnormal_synaptic_plasticity	0.59050918
97	MP0005083_abnormal_biliary_tract	0.58650145
98	MP0003186_abnormal_redox_activity	0.58123288
99	MP0003634_abnormal_glial_cell	0.57171436
100	MP0000747_muscle_weakness	0.55906757

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Choroideremia (HP:0001139)	7.06697007
2	Complement deficiency (HP:0004431)	6.12955864
3	Abnormality of the fovea (HP:0000493)	6.05379065
4	Abnormal rod and cone electroretinograms (HP:0008323)	5.36964356
5	Facial shape deformation (HP:0011334)	4.97466164
6	Potter facies (HP:0002009)	4.97466164
7	Vacuolated lymphocytes (HP:0001922)	4.94060686
8	Vascular calcification (HP:0004934)	4.68827960
9	Myocardial infarction (HP:0001658)	4.58075198
10	Bony spicule pigmentary retinopathy (HP:0007737)	4.57817650
11	Abnormality of complement system (HP:0005339)	4.41375557
12	Cardiovascular calcification (HP:0011915)	4.34615862
13	Neurofibrillary tangles (HP:0002185)	4.29719072
14	Recurrent gram-negative bacterial infections (HP:0005420)	4.18527565
15	Hypopigmentation of the fundus (HP:0007894)	4.17287088
16	Hypophosphatemic rickets (HP:0004912)	4.11117367
17	Cerebral inclusion bodies (HP:0100314)	4.04890675
18	Intention tremor (HP:0002080)	3.63269053
19	Infantile muscular hypotonia (HP:0008947)	3.29389307
20	Metaphyseal cupping (HP:0003021)	3.19475268
21	Action tremor (HP:0002345)	3.11751883
22	Hand muscle atrophy (HP:0009130)	3.07777041
23	Hyperglycinuria (HP:0003108)	3.07222901
24	Supranuclear gaze palsy (HP:0000605)	2.95865230
25	Neoplasm of the heart (HP:0100544)	2.95766018
26	Agitation (HP:0000713)	2.95174688
27	Hyperphosphatemia (HP:0002905)	2.87186433
28	Hemiplegia (HP:0002301)	2.83489283
29	Dysostosis multiplex (HP:0000943)	2.80200330
30	Malnutrition (HP:0004395)	2.77671132
31	Stridor (HP:0010307)	2.70749722
32	Upper limb amyotrophy (HP:0009129)	2.66832989
33	Distal upper limb amyotrophy (HP:0007149)	2.66832989
34	Acanthosis nigricans (HP:0000956)	2.64495803
35	Abnormality of glycine metabolism (HP:0010895)	2.62243180
36	Abnormality of serine family amino acid metabolism (HP:0010894)	2.62243180
37	Ketoacidosis (HP:0001993)	2.60376516
38	Oligomenorrhea (HP:0000876)	2.59186230
39	Polar cataract (HP:0010696)	2.55421286
40	Hyperglycinemia (HP:0002154)	2.52515291
41	Rickets (HP:0002748)	2.51858083
42	Hypertriglyceridemia (HP:0002155)	2.44388230
43	Facial diplegia (HP:0001349)	2.43940742
44	11 pairs of ribs (HP:0000878)	2.42403675
45	Diaphragmatic weakness (HP:0009113)	2.39383834
46	Xanthomatosis (HP:0000991)	2.34127133
47	Hemorrhage of the eye (HP:0011885)	2.30203811
48	Tubulointerstitial fibrosis (HP:0005576)	2.25502347
49	Abnormal hemoglobin (HP:0011902)	2.23983950
50	Subcapsular cataract (HP:0000523)	2.21591791
51	Ketosis (HP:0001946)	2.20496560
52	Focal segmental glomerulosclerosis (HP:0000097)	2.20482827
53	Widely patent fontanelles and sutures (HP:0004492)	2.19846093
54	Skin nodule (HP:0200036)	2.19839657
55	Abnormality of purine metabolism (HP:0004352)	2.16920977
56	Deep venous thrombosis (HP:0002625)	2.15008081
57	Abnormality of macular pigmentation (HP:0008002)	2.10865908
58	Loss of speech (HP:0002371)	2.09266967
59	Restlessness (HP:0000711)	2.09066527
60	Osteomalacia (HP:0002749)	2.08673768
61	Missing ribs (HP:0000921)	2.08417642
62	Choreoathetosis (HP:0001266)	2.06541515
63	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.05877803
64	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.05877803
65	Ectopia lentis (HP:0001083)	2.05664446
66	Difficulty running (HP:0009046)	2.04448323
67	Systemic lupus erythematosus (HP:0002725)	2.03807544
68	Mucopolysacchariduria (HP:0008155)	1.97680146
69	Urinary glycosaminoglycan excretion (HP:0003541)	1.97680146
70	Clumsiness (HP:0002312)	1.96005586
71	Abnormality of macrophages (HP:0004311)	1.91464505
72	Ankle clonus (HP:0011448)	1.90144959
73	Muscle fiber splitting (HP:0003555)	1.84254854
74	Glomerulosclerosis (HP:0000096)	1.83296594
75	Central scotoma (HP:0000603)	1.82418221
76	Thin bony cortex (HP:0002753)	1.82237084
77	Abnormality of the calcaneus (HP:0008364)	1.78952233
78	Abnormality of polysaccharide metabolism (HP:0011012)	1.78907738
79	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.78907738
80	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.78907738
81	Hyporeflexia of lower limbs (HP:0002600)	1.78750649
82	Gout (HP:0001997)	1.78568456
83	Testicular atrophy (HP:0000029)	1.77581698
84	Pseudobulbar signs (HP:0002200)	1.73710110
85	Hyperammonemia (HP:0001987)	1.73146028
86	Progressive neurologic deterioration (HP:0002344)	1.73036423
87	Epidermoid cyst (HP:0200040)	1.72569550
88	Right ventricular cardiomyopathy (HP:0011663)	1.72404121
89	Hyperparathyroidism (HP:0000843)	1.70876859
90	Cardiomegaly (HP:0001640)	1.69164577
91	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.69112669
92	Abnormality of the lumbar spine (HP:0100712)	1.68756353
93	Back pain (HP:0003418)	1.65705047
94	Hypoventilation (HP:0002791)	1.64471087
95	Hypophosphatemia (HP:0002148)	1.64368495
96	Intrahepatic cholestasis (HP:0001406)	1.62987279
97	Mutism (HP:0002300)	1.61614504
98	Macular degeneration (HP:0000608)	1.61523335
99	Growth hormone excess (HP:0000845)	1.61450538
100	Proximal tubulopathy (HP:0000114)	1.58947109

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	SIK1	3.50148661
2	ERN1	3.43698861
3	LMTK2	3.36514769
4	TRIB3	3.27047210
5	TAOK3	3.00519092
6	MST4	2.83821881
7	PKN2	2.71185455
8	WNK4	2.59374277
9	EPHB1	2.35833329
10	LRRK2	2.15219792
11	PDGFRA	2.01496298
12	MYLK	1.96044516
13	FER	1.84382933
14	PRKD3	1.82064820
15	FGFR2	1.74359047
16	RIPK4	1.58461805
17	FGFR4	1.54055826
18	TTN	1.47984292
19	BCKDK	1.43456968
20	RET	1.41265377
21	FRK	1.37187275
22	MAP2K4	1.30097828
23	PTK2	1.26822792
24	PTK6	1.25185414
25	PAK3	1.24767033
26	STK39	1.23357818
27	MAP3K2	1.19596071
28	TNK2	1.16912915
29	NTRK1	1.13759862
30	PTK2B	1.13467662
31	RIPK1	1.10499289
32	CAMK1G	1.04927759
33	WNK1	1.04749857
34	CAMK1D	1.04372659
35	LATS1	1.01181036
36	PRKCH	1.00972495
37	PAK2	1.00207548
38	EPHB2	0.98376447
39	FLT3	0.98039502
40	DDR2	0.96647154
41	BMX	0.96620287
42	TYRO3	0.96135759
43	INSR	0.91457250
44	LATS2	0.89803504
45	CDK19	0.89549547
46	KSR2	0.88449997
47	TESK1	0.86787129
48	MAP3K6	0.86559959
49	DMPK	0.84740323
50	PAK6	0.83677416
51	INSRR	0.83413244
52	FGFR3	0.81236095
53	PDK4	0.78785271
54	PDK3	0.78785271
55	STK38	0.77685904
56	EEF2K	0.76546451
57	ICK	0.76474977
58	PHKG2	0.76085081
59	PHKG1	0.76085081
60	JAK2	0.76021787
61	SIK2	0.74089555
62	NTRK3	0.73712131
63	MAP3K4	0.72392609
64	MAP2K1	0.71943121
65	STK10	0.70182583
66	SCYL2	0.65768351
67	PRKCZ	0.65414392
68	PAK4	0.64945989
69	SRC	0.64263425
70	MET	0.63490311
71	EGFR	0.62384635
72	STK38L	0.61489801
73	PRKCG	0.61472785
74	IRAK2	0.60913445
75	PDGFRB	0.59123913
76	CDK5	0.58594742
77	IRAK3	0.58463629
78	GSK3A	0.58387423
79	MAP3K7	0.58374459
80	FYN	0.57563796
81	AKT3	0.55380666
82	ILK	0.54745629
83	MAP3K12	0.54359519
84	ERBB2	0.53633217
85	PRKD1	0.53260448
86	EPHA2	0.52746533
87	FGFR1	0.50934588
88	PRKACG	0.50380887
89	MST1R	0.48845202
90	GRK6	0.48767114
91	PDK2	0.47716201
92	GRK5	0.46361436
93	CDK6	0.46128556
94	ALK	0.44635584
95	DAPK2	0.44155437
96	JAK1	0.42800548
97	PDK1	0.42010992
98	PDPK1	0.41643924
99	CSNK1E	0.41162057
100	MINK1	0.39213633

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	4.43998368
2	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.59793266
3	Glutathione metabolism_Homo sapiens_hsa00480	3.40622516
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.00814929
5	Thyroid hormone synthesis_Homo sapiens_hsa04918	2.77013238
6	Tryptophan metabolism_Homo sapiens_hsa00380	2.74239187
7	Arachidonic acid metabolism_Homo sapiens_hsa00590	2.72808862
8	Sulfur metabolism_Homo sapiens_hsa00920	2.55008685
9	Fatty acid metabolism_Homo sapiens_hsa01212	2.37342860
10	Fatty acid degradation_Homo sapiens_hsa00071	2.33512204
11	PPAR signaling pathway_Homo sapiens_hsa03320	2.28453304
12	African trypanosomiasis_Homo sapiens_hsa05143	2.27113192
13	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.98098159
14	Glycerolipid metabolism_Homo sapiens_hsa00561	1.92823413
15	Arginine biosynthesis_Homo sapiens_hsa00220	1.74878301
16	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.74494800
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.71232960
18	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.55546647
19	ABC transporters_Homo sapiens_hsa02010	1.50145469
20	Propanoate metabolism_Homo sapiens_hsa00640	1.46566699
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.46523672
22	Salivary secretion_Homo sapiens_hsa04970	1.45066323
23	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.36945819
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.36186603
25	Phenylalanine metabolism_Homo sapiens_hsa00360	1.30553339
26	Lysosome_Homo sapiens_hsa04142	1.29345697
27	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.27239866
28	Other glycan degradation_Homo sapiens_hsa00511	1.25577788
29	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.24820524
30	Fat digestion and absorption_Homo sapiens_hsa04975	1.21824228
31	Complement and coagulation cascades_Homo sapiens_hsa04610	1.20979440
32	beta-Alanine metabolism_Homo sapiens_hsa00410	1.15133107
33	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.14667148
34	Renin secretion_Homo sapiens_hsa04924	1.05393172
35	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.03386524
36	Pyruvate metabolism_Homo sapiens_hsa00620	1.02663840
37	Tyrosine metabolism_Homo sapiens_hsa00350	1.02590435
38	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.02578463
39	Prion diseases_Homo sapiens_hsa05020	0.98482200
40	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.95177538
41	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.95121207
42	Butanoate metabolism_Homo sapiens_hsa00650	0.90162564
43	Carbon metabolism_Homo sapiens_hsa01200	0.89683039
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.87344892
45	Gastric acid secretion_Homo sapiens_hsa04971	0.84862784
46	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.84551194
47	Bile secretion_Homo sapiens_hsa04976	0.82593798
48	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.81925819
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.75175201
50	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.73398117
51	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.73151540
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.71409834
53	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.68685755
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.68549766
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66479202
56	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.66042118
57	Estrogen signaling pathway_Homo sapiens_hsa04915	0.65674473
58	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.65139430
59	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.64453377
60	Vibrio cholerae infection_Homo sapiens_hsa05110	0.63802470
61	Peroxisome_Homo sapiens_hsa04146	0.63801995
62	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.61195550
63	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.54938018
64	GABAergic synapse_Homo sapiens_hsa04727	0.54866984
65	Fatty acid elongation_Homo sapiens_hsa00062	0.50564904
66	Long-term potentiation_Homo sapiens_hsa04720	0.49532629
67	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.48533387
68	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.48251189
69	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.45551219
70	Arginine and proline metabolism_Homo sapiens_hsa00330	0.45438228
71	Circadian entrainment_Homo sapiens_hsa04713	0.44120183
72	Histidine metabolism_Homo sapiens_hsa00340	0.42232792
73	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.42098685
74	AMPK signaling pathway_Homo sapiens_hsa04152	0.40648588
75	Insulin resistance_Homo sapiens_hsa04931	0.38170333
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.37090830
77	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.36578761
78	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.35468144
79	cAMP signaling pathway_Homo sapiens_hsa04024	0.34531008
80	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.34509321
81	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.34220648
82	Protein digestion and absorption_Homo sapiens_hsa04974	0.33023350
83	Glucagon signaling pathway_Homo sapiens_hsa04922	0.31690374
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.31324230
85	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.31309981
86	Type II diabetes mellitus_Homo sapiens_hsa04930	0.29773525
87	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.28847585
88	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.26861805
89	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.25892503
90	Insulin secretion_Homo sapiens_hsa04911	0.24923353
91	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.21620364
92	Pancreatic secretion_Homo sapiens_hsa04972	0.21605367
93	Amphetamine addiction_Homo sapiens_hsa05031	0.21133544
94	GnRH signaling pathway_Homo sapiens_hsa04912	0.21033103
95	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.20879465
96	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.20001440
97	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.19996431
98	Glutamatergic synapse_Homo sapiens_hsa04724	0.18988557
99	Melanogenesis_Homo sapiens_hsa04916	0.18934507
100	Calcium signaling pathway_Homo sapiens_hsa04020	0.17888927

RNASE9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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