ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chromatin remodeling at centromere (GO:0031055)	4.20290643
2	CENP-A containing nucleosome assembly (GO:0034080)	4.09471530
3	L-serine metabolic process (GO:0006563)	3.80965680
4	histone exchange (GO:0043486)	3.49041856
5	DNA replication-independent nucleosome assembly (GO:0006336)	3.47629692
6	DNA replication-independent nucleosome organization (GO:0034724)	3.47629692
7	cullin deneddylation (GO:0010388)	3.47502634
8	cholesterol biosynthetic process (GO:0006695)	3.45746250
9	purine nucleobase biosynthetic process (GO:0009113)	3.33631031
10	negative regulation of DNA recombination (GO:0045910)	3.30942653
11	DNA double-strand break processing (GO:0000729)	3.28995807
12	pyrimidine nucleobase catabolic process (GO:0006208)	3.27636608
13	tRNA aminoacylation for protein translation (GO:0006418)	3.27266642
14	establishment of integrated proviral latency (GO:0075713)	3.25929492
15	resolution of meiotic recombination intermediates (GO:0000712)	3.24389731
16	DNA damage response, detection of DNA damage (GO:0042769)	3.22517093
17	DNA replication checkpoint (GO:0000076)	3.18112889
18	mitotic sister chromatid segregation (GO:0000070)	3.16776234
19	tRNA aminoacylation (GO:0043039)	3.15854354
20	amino acid activation (GO:0043038)	3.15854354
21	sterol biosynthetic process (GO:0016126)	3.15626447
22	IMP biosynthetic process (GO:0006188)	3.14731382
23	non-recombinational repair (GO:0000726)	3.14563130
24	double-strand break repair via nonhomologous end joining (GO:0006303)	3.14563130
25	protein deneddylation (GO:0000338)	3.14029109
26	metaphase plate congression (GO:0051310)	3.05563929
27	DNA strand elongation involved in DNA replication (GO:0006271)	3.04277470
28	microtubule depolymerization (GO:0007019)	3.01395492
29	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.00023026
30	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.00023026
31	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.99377495
32	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.99377495
33	sister chromatid segregation (GO:0000819)	2.98803714
34	mitotic metaphase plate congression (GO:0007080)	2.96841909
35	positive regulation of mitochondrial fission (GO:0090141)	2.95300290
36	proteasome assembly (GO:0043248)	2.95049792
37	mitotic spindle checkpoint (GO:0071174)	2.92944021
38	telomere maintenance via semi-conservative replication (GO:0032201)	2.92570639
39	kinetochore assembly (GO:0051382)	2.92145558
40	nucleobase biosynthetic process (GO:0046112)	2.91659554
41	DNA ligation (GO:0006266)	2.89931319
42	protein localization to kinetochore (GO:0034501)	2.89610773
43	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.89484877
44	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.87874124
45	DNA strand elongation (GO:0022616)	2.86350256
46	synapsis (GO:0007129)	2.85497376
47	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.85079716
48	establishment of viral latency (GO:0019043)	2.83818772
49	kinetochore organization (GO:0051383)	2.82839664
50	protein-cofactor linkage (GO:0018065)	2.82262951
51	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.82252637
52	histone H2A acetylation (GO:0043968)	2.82076711
53	ATP-dependent chromatin remodeling (GO:0043044)	2.81865022
54	spindle checkpoint (GO:0031577)	2.80754313
55	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.80736847
56	isoprenoid biosynthetic process (GO:0008299)	2.79126417
57	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.77252582
58	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.77252582
59	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.77252582
60	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.77252582
61	negative regulation of sister chromatid segregation (GO:0033046)	2.77252582
62	negative regulation of chromosome segregation (GO:0051985)	2.71921700
63	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.71105359
64	organelle disassembly (GO:1903008)	2.69529312
65	mitotic spindle assembly checkpoint (GO:0007094)	2.68375452
66	serine family amino acid biosynthetic process (GO:0009070)	2.68139932
67	ubiquinone metabolic process (GO:0006743)	2.68039718
68	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.67896622
69	regulation of mitotic spindle checkpoint (GO:1903504)	2.66693172
70	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.66693172
71	IMP metabolic process (GO:0046040)	2.65548903
72	intraciliary transport (GO:0042073)	2.65055585
73	spindle assembly checkpoint (GO:0071173)	2.63651441
74	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.62701139
75	DNA catabolic process, exonucleolytic (GO:0000738)	2.61375015
76	attachment of spindle microtubules to kinetochore (GO:0008608)	2.61316234
77	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.61267738
78	negative regulation of ligase activity (GO:0051352)	2.61267738
79	regulation of helicase activity (GO:0051095)	2.59216448
80	formation of translation preinitiation complex (GO:0001731)	2.59152663
81	oxidative phosphorylation (GO:0006119)	2.57209840
82	regulation of cofactor metabolic process (GO:0051193)	2.55481177
83	regulation of coenzyme metabolic process (GO:0051196)	2.55481177
84	DNA integration (GO:0015074)	2.55194616
85	telomere maintenance via recombination (GO:0000722)	2.53219844
86	nucleobase catabolic process (GO:0046113)	2.52986694
87	replication fork processing (GO:0031297)	2.52758719
88	nuclear pore organization (GO:0006999)	2.52028741
89	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.51140035
90	chaperone-mediated protein transport (GO:0072321)	2.48275664
91	mitotic recombination (GO:0006312)	2.47864360
92	DNA replication-dependent nucleosome organization (GO:0034723)	2.47625699
93	DNA replication-dependent nucleosome assembly (GO:0006335)	2.47625699
94	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.47114998
95	peptidyl-cysteine modification (GO:0018198)	2.45752217
96	DNA replication initiation (GO:0006270)	2.45450345
97	mitotic nuclear envelope disassembly (GO:0007077)	2.44805514
98	ribonucleoprotein complex disassembly (GO:0032988)	2.44481269
99	nonmotile primary cilium assembly (GO:0035058)	2.44446036
100	protein localization to chromosome, centromeric region (GO:0071459)	2.43957959

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	4.37175914
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.31697790
3	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.65491592
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.46287204
5	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.15065527
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.07333064
7	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.79408984
8	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.68755649
9	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.60737833
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.58155694
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.57759641
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.45648471
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.45186581
14	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.40052996
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.39208920
16	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.35681894
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.32147411
18	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.31254063
19	ZNF274_21170338_ChIP-Seq_K562_Hela	2.27778008
20	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.27575497
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.23334419
22	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.11999100
23	IGF1R_20145208_ChIP-Seq_DFB_Human	2.10599339
24	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.08574040
25	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.06573992
26	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.98086397
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.97160399
28	VDR_23849224_ChIP-Seq_CD4+_Human	1.96313409
29	GABP_19822575_ChIP-Seq_HepG2_Human	1.96275677
30	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.95103271
31	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.94339085
32	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.93662000
33	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.91387633
34	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.87829026
35	DCP1A_22483619_ChIP-Seq_HELA_Human	1.84321303
36	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.80941046
37	FOXP3_21729870_ChIP-Seq_TREG_Human	1.78085820
38	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.76773403
39	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.76706350
40	TTF2_22483619_ChIP-Seq_HELA_Human	1.71269690
41	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.70670103
42	XRN2_22483619_ChIP-Seq_HELA_Human	1.70661314
43	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.70368355
44	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.67184957
45	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.66012339
46	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.65469145
47	MYC_18940864_ChIP-ChIP_HL60_Human	1.63918137
48	FUS_26573619_Chip-Seq_HEK293_Human	1.63226522
49	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.61683733
50	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.60230241
51	EWS_26573619_Chip-Seq_HEK293_Human	1.58294666
52	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.57054331
53	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.55482133
54	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.54778545
55	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.54175379
56	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.50245553
57	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.45087123
58	VDR_22108803_ChIP-Seq_LS180_Human	1.44212814
59	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.39342099
60	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.35909892
61	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.34213242
62	TAF15_26573619_Chip-Seq_HEK293_Human	1.33177204
63	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.32759116
64	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.31207220
65	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.30109043
66	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.27456819
67	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.26111175
68	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.24366093
69	AR_21909140_ChIP-Seq_LNCAP_Human	1.20053566
70	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.14712997
71	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.13116717
72	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.11882208
73	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.09275477
74	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.09237790
75	EZH2_22144423_ChIP-Seq_EOC_Human	1.08133901
76	KDM5A_27292631_Chip-Seq_BREAST_Human	1.07887898
77	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.06829776
78	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.06639794
79	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.05590545
80	NANOG_21062744_ChIP-ChIP_HESCs_Human	1.02717264
81	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.02507381
82	CIITA_25753668_ChIP-Seq_RAJI_Human	1.01609322
83	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.01392053
84	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.00951299
85	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.98548668
86	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.97823604
87	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.96639818
88	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.96586939
89	TP53_22573176_ChIP-Seq_HFKS_Human	0.93548289
90	GBX2_23144817_ChIP-Seq_PC3_Human	0.93221189
91	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.91493473
92	P300_19829295_ChIP-Seq_ESCs_Human	0.90747855
93	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.90722199
94	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.88683479
95	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.87327788
96	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.86467358
97	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.85235724
98	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.82672152
99	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.80769004
100	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.80450080

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003122_maternal_imprinting	3.14045036
2	MP0002102_abnormal_ear_morphology	3.04307716
3	MP0006292_abnormal_olfactory_placode	2.96298045
4	MP0005394_taste/olfaction_phenotype	2.79919860
5	MP0005499_abnormal_olfactory_system	2.79919860
6	MP0001529_abnormal_vocalization	2.78590150
7	MP0008789_abnormal_olfactory_epithelium	2.70543265
8	MP0008058_abnormal_DNA_repair	2.67153400
9	MP0003693_abnormal_embryo_hatching	2.47090049
10	MP0010094_abnormal_chromosome_stability	2.45765864
11	MP0001293_anophthalmia	2.31039304
12	MP0002938_white_spotting	2.23705778
13	MP0009697_abnormal_copulation	2.22279980
14	MP0008932_abnormal_embryonic_tissue	2.20761999
15	MP0008877_abnormal_DNA_methylation	2.17176066
16	MP0004957_abnormal_blastocyst_morpholog	2.17055506
17	MP0003111_abnormal_nucleus_morphology	2.11952698
18	MP0010030_abnormal_orbit_morphology	2.03026948
19	MP0004147_increased_porphyrin_level	1.94563016
20	MP0003890_abnormal_embryonic-extraembry	1.93881227
21	MP0003121_genomic_imprinting	1.93213953
22	MP0004133_heterotaxia	1.92890123
23	MP0001984_abnormal_olfaction	1.84293564
24	MP0003880_abnormal_central_pattern	1.77091685
25	MP0003077_abnormal_cell_cycle	1.69715511
26	MP0003718_maternal_effect	1.69125072
27	MP0003937_abnormal_limbs/digits/tail_de	1.62903763
28	MP0003567_abnormal_fetal_cardiomyocyte	1.57021139
29	MP0006035_abnormal_mitochondrial_morpho	1.56016673
30	MP0006276_abnormal_autonomic_nervous	1.53526937
31	MP0002233_abnormal_nose_morphology	1.44969106
32	MP0005248_abnormal_Harderian_gland	1.44358438
33	MP0008995_early_reproductive_senescence	1.43687472
34	MP0003221_abnormal_cardiomyocyte_apopto	1.42976967
35	MP0003119_abnormal_digestive_system	1.42813220
36	MP0000049_abnormal_middle_ear	1.39247163
37	MP0008007_abnormal_cellular_replicative	1.38230117
38	MP0003787_abnormal_imprinting	1.35816538
39	MP0002653_abnormal_ependyma_morphology	1.35533778
40	MP0001286_abnormal_eye_development	1.34308044
41	MP0000647_abnormal_sebaceous_gland	1.32679428
42	MP0006072_abnormal_retinal_apoptosis	1.31453345
43	MP0000778_abnormal_nervous_system	1.30309241
44	MP0002751_abnormal_autonomic_nervous	1.26753578
45	MP0002638_abnormal_pupillary_reflex	1.22754186
46	MP0002697_abnormal_eye_size	1.22526042
47	MP0005253_abnormal_eye_physiology	1.21041962
48	MP0002084_abnormal_developmental_patter	1.21019007
49	MP0003938_abnormal_ear_development	1.20447548
50	MP0002085_abnormal_embryonic_tissue	1.12855429
51	MP0003861_abnormal_nervous_system	1.12125221
52	MP0001730_embryonic_growth_arrest	1.10533569
53	MP0006054_spinal_hemorrhage	1.09130822
54	MP0001299_abnormal_eye_distance/	1.05732834
55	MP0009672_abnormal_birth_weight	1.05670435
56	MP0003755_abnormal_palate_morphology	1.05216296
57	MP0004197_abnormal_fetal_growth/weight/	1.05028557
58	MP0009703_decreased_birth_body	1.04889819
59	MP0003136_yellow_coat_color	1.04785583
60	MP0000566_synostosis	1.04659606
61	MP0001672_abnormal_embryogenesis/_devel	1.04191450
62	MP0005380_embryogenesis_phenotype	1.04191450
63	MP0002234_abnormal_pharynx_morphology	1.04040614
64	MP0001697_abnormal_embryo_size	1.01918499
65	MP0003186_abnormal_redox_activity	1.00264368
66	MP0005391_vision/eye_phenotype	0.99594102
67	MP0003786_premature_aging	0.99396938
68	MP0000358_abnormal_cell_content/	0.96584862
69	MP0003385_abnormal_body_wall	0.94537570
70	MP0003984_embryonic_growth_retardation	0.92226245
71	MP0003646_muscle_fatigue	0.90602921
72	MP0001929_abnormal_gametogenesis	0.88646532
73	MP0005171_absent_coat_pigmentation	0.88386310
74	MP0002090_abnormal_vision	0.88384793
75	MP0002088_abnormal_embryonic_growth/wei	0.88366766
76	MP0004270_analgesia	0.88331724
77	MP0002210_abnormal_sex_determination	0.87356418
78	MP0003137_abnormal_impulse_conducting	0.86601366
79	MP0001764_abnormal_homeostasis	0.86298669
80	MP0002111_abnormal_tail_morphology	0.84858841
81	MP0004145_abnormal_muscle_electrophysio	0.84593672
82	MP0002249_abnormal_larynx_morphology	0.83736972
83	MP0002152_abnormal_brain_morphology	0.83031848
84	MP0002080_prenatal_lethality	0.81484219
85	MP0003698_abnormal_male_reproductive	0.81426345
86	MP0002092_abnormal_eye_morphology	0.81268781
87	MP0002752_abnormal_somatic_nervous	0.80894212
88	MP0000955_abnormal_spinal_cord	0.80802124
89	MP0002557_abnormal_social/conspecific_i	0.80599330
90	MP0004859_abnormal_synaptic_plasticity	0.79913128
91	MP0006036_abnormal_mitochondrial_physio	0.79445093
92	MP0000631_abnormal_neuroendocrine_gland	0.78885530
93	MP0002184_abnormal_innervation	0.78505899
94	MP0000428_abnormal_craniofacial_morphol	0.75797410
95	MP0000372_irregular_coat_pigmentation	0.75514598
96	MP0003935_abnormal_craniofacial_develop	0.75457735
97	MP0003941_abnormal_skin_development	0.75262033
98	MP0000653_abnormal_sex_gland	0.75180173
99	MP0001986_abnormal_taste_sensitivity	0.74986883
100	MP0004811_abnormal_neuron_physiology	0.72658891

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Cortical dysplasia (HP:0002539)	4.56010238
2	Abnormality of the labia minora (HP:0012880)	4.22999077
3	Increased serum pyruvate (HP:0003542)	3.39057407
4	Abnormality of glycolysis (HP:0004366)	3.30575101
5	Supernumerary spleens (HP:0009799)	3.22073041
6	Hyperglycinemia (HP:0002154)	3.15914357
7	Congenital primary aphakia (HP:0007707)	3.02554317
8	Colon cancer (HP:0003003)	3.01356370
9	Medial flaring of the eyebrow (HP:0010747)	2.99621513
10	Gait imbalance (HP:0002141)	2.95059949
11	Nephrogenic diabetes insipidus (HP:0009806)	2.93911095
12	Cholecystitis (HP:0001082)	2.92103291
13	Abnormal gallbladder physiology (HP:0012438)	2.92103291
14	Pancreatic fibrosis (HP:0100732)	2.80801747
15	Abnormal lung lobation (HP:0002101)	2.72721610
16	Intestinal atresia (HP:0011100)	2.69563620
17	Chromsome breakage (HP:0040012)	2.65242264
18	Pancreatic cysts (HP:0001737)	2.60839488
19	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.59793877
20	Meckel diverticulum (HP:0002245)	2.56544765
21	Abnormality of the ileum (HP:0001549)	2.52873978
22	True hermaphroditism (HP:0010459)	2.51249551
23	Abnormal hair whorl (HP:0010721)	2.49936601
24	Acute encephalopathy (HP:0006846)	2.48965251
25	Vaginal atresia (HP:0000148)	2.40336745
26	Genital tract atresia (HP:0001827)	2.39943968
27	Poor coordination (HP:0002370)	2.37987108
28	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.30860790
29	Acute necrotizing encephalopathy (HP:0006965)	2.26796872
30	Broad foot (HP:0001769)	2.24338806
31	Abnormality of chromosome stability (HP:0003220)	2.18071317
32	Preaxial hand polydactyly (HP:0001177)	2.16289492
33	Labial hypoplasia (HP:0000066)	2.10296261
34	Abnormal mitochondria in muscle tissue (HP:0008316)	2.09220281
35	Microvesicular hepatic steatosis (HP:0001414)	2.08588899
36	Horseshoe kidney (HP:0000085)	2.08434889
37	Hypoplastic pelvis (HP:0008839)	2.06941390
38	Abnormality of serum amino acid levels (HP:0003112)	2.05593212
39	Hypoplastic female external genitalia (HP:0012815)	2.05432059
40	Postnatal microcephaly (HP:0005484)	2.04261435
41	Abnormality of alanine metabolism (HP:0010916)	2.03465143
42	Hyperalaninemia (HP:0003348)	2.03465143
43	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.03465143
44	Hepatoblastoma (HP:0002884)	2.03297654
45	Oligodactyly (hands) (HP:0001180)	2.01692163
46	Abnormality of serine family amino acid metabolism (HP:0010894)	2.00428454
47	Abnormality of glycine metabolism (HP:0010895)	2.00428454
48	Postaxial foot polydactyly (HP:0001830)	1.99469932
49	Abnormality of the duodenum (HP:0002246)	1.98583646
50	Oligodactyly (HP:0012165)	1.98547845
51	Polyphagia (HP:0002591)	1.97969182
52	Small intestinal stenosis (HP:0012848)	1.97728600
53	Duodenal stenosis (HP:0100867)	1.97728600
54	Specific learning disability (HP:0001328)	1.96490873
55	Hyperglycinuria (HP:0003108)	1.96372913
56	Exercise-induced muscle cramps (HP:0003710)	1.96296206
57	Sloping forehead (HP:0000340)	1.96238008
58	Decreased testicular size (HP:0008734)	1.95663483
59	Short tibia (HP:0005736)	1.95531312
60	Postaxial hand polydactyly (HP:0001162)	1.94230417
61	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.93239100
62	Anophthalmia (HP:0000528)	1.92905963
63	Bifid tongue (HP:0010297)	1.90723813
64	Hepatocellular necrosis (HP:0001404)	1.88850846
65	Occipital encephalocele (HP:0002085)	1.88010573
66	Ependymoma (HP:0002888)	1.87252839
67	Abnormality of cochlea (HP:0000375)	1.86989447
68	Abnormality of the preputium (HP:0100587)	1.86892889
69	Triphalangeal thumb (HP:0001199)	1.84100486
70	Abnormality of the metopic suture (HP:0005556)	1.83256505
71	Reticulocytopenia (HP:0001896)	1.82502228
72	Increased CSF lactate (HP:0002490)	1.81819190
73	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.81632394
74	Pancreatic islet-cell hyperplasia (HP:0004510)	1.79635396
75	Increased serum lactate (HP:0002151)	1.78963646
76	Dandy-Walker malformation (HP:0001305)	1.78758612
77	Anencephaly (HP:0002323)	1.78145058
78	CNS hypomyelination (HP:0003429)	1.77439108
79	Cerebral edema (HP:0002181)	1.77424220
80	Abdominal situs inversus (HP:0003363)	1.77342293
81	Abnormality of abdominal situs (HP:0011620)	1.77342293
82	Aganglionic megacolon (HP:0002251)	1.76675807
83	Abnormal biliary tract physiology (HP:0012439)	1.75816983
84	Bile duct proliferation (HP:0001408)	1.75816983
85	Degeneration of anterior horn cells (HP:0002398)	1.75731717
86	Abnormality of the anterior horn cell (HP:0006802)	1.75731717
87	Medulloblastoma (HP:0002885)	1.75597165
88	Hemivertebrae (HP:0002937)	1.75472112
89	Abnormality of the labia (HP:0000058)	1.75119473
90	Absent radius (HP:0003974)	1.74758469
91	Cerebral hypomyelination (HP:0006808)	1.74197817
92	Stenosis of the external auditory canal (HP:0000402)	1.73864087
93	Optic nerve coloboma (HP:0000588)	1.72135429
94	Sclerocornea (HP:0000647)	1.71187597
95	Upper limb muscle weakness (HP:0003484)	1.71187363
96	Increased nuchal translucency (HP:0010880)	1.68589752
97	Mitochondrial inheritance (HP:0001427)	1.68304860
98	Nephronophthisis (HP:0000090)	1.68286051
99	Lissencephaly (HP:0001339)	1.68248780
100	Aplasia involving forearm bones (HP:0009822)	1.68175830

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	3.78085048
2	SRPK1	3.41905689
3	BCR	3.09894466
4	NEK1	3.03871485
5	MAP4K2	2.97689713
6	BUB1	2.96151572
7	MAP3K4	2.86083586
8	MAP2K7	2.73555981
9	WNK3	2.41762490
10	EIF2AK1	2.39619221
11	TSSK6	2.29373152
12	TTK	2.21451178
13	CDC7	2.09561767
14	MKNK1	1.97476535
15	PLK3	1.89513126
16	PLK4	1.86288878
17	EPHA4	1.76120244
18	MKNK2	1.74430041
19	PBK	1.72307781
20	ZAK	1.68961057
21	DYRK2	1.64682665
22	CDK19	1.62454459
23	DYRK3	1.61324571
24	BCKDK	1.60338388
25	BMPR1B	1.51349424
26	CSNK1G3	1.50042065
27	ERBB3	1.44859520
28	MARK1	1.43244824
29	CSNK1G1	1.43124875
30	BRSK2	1.40969965
31	PLK2	1.38743507
32	CSNK1G2	1.37256580
33	PLK1	1.33492771
34	WEE1	1.27839970
35	CSNK1A1L	1.26941586
36	RPS6KA4	1.26191417
37	PDK2	1.20616514
38	EIF2AK3	1.18355279
39	NME1	1.14497251
40	NEK2	1.11065186
41	TNIK	1.06736481
42	BRSK1	1.06544144
43	ATR	1.02245970
44	VRK1	1.01234662
45	ACVR1B	1.00699913
46	FLT3	1.00460438
47	DYRK1B	0.96536622
48	VRK2	0.92883584
49	AURKB	0.84961097
50	GRK1	0.84796974
51	SIK3	0.84144120
52	PINK1	0.82523570
53	CLK1	0.77256959
54	CHEK2	0.76991799
55	MAPK13	0.75085028
56	ADRBK2	0.74680115
57	NUAK1	0.74440091
58	BRD4	0.73413040
59	STK16	0.73099552
60	CCNB1	0.72459125
61	CHEK1	0.68551230
62	ATM	0.67249518
63	FGFR1	0.66822426
64	PRKCG	0.66317430
65	STK38L	0.63842430
66	CDK14	0.62038427
67	CDK18	0.60124363
68	MINK1	0.58499230
69	MAP2K4	0.57851852
70	CASK	0.52982151
71	CDK11A	0.52514601
72	CSNK2A1	0.52151402
73	PASK	0.51627649
74	WNK4	0.50960586
75	KSR1	0.50154971
76	CDK15	0.49799415
77	CDK1	0.48243761
78	CSNK1E	0.47375222
79	DYRK1A	0.46619612
80	CDK2	0.46431169
81	AURKA	0.46397850
82	NTRK3	0.45506040
83	PRKCE	0.45178744
84	NTRK2	0.43167591
85	PAK3	0.40983431
86	CSNK2A2	0.39781400
87	MAP3K5	0.38973632
88	CSNK1A1	0.37940650
89	TESK2	0.36904074
90	UHMK1	0.34914079
91	PRKACB	0.34502976
92	DAPK1	0.33260956
93	LIMK1	0.32577411
94	PRKDC	0.31945007
95	STK4	0.31318133
96	PAK6	0.31268679
97	TESK1	0.29964399
98	ALK	0.29822548
99	ERBB4	0.29051704
100	EPHA3	0.28351831

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.86371220
2	Steroid biosynthesis_Homo sapiens_hsa00100	2.85607974
3	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.81631965
4	Mismatch repair_Homo sapiens_hsa03430	2.80155582
5	Proteasome_Homo sapiens_hsa03050	2.76382915
6	DNA replication_Homo sapiens_hsa03030	2.61845263
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.47840337
8	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.25974911
9	Non-homologous end-joining_Homo sapiens_hsa03450	2.21978577
10	Propanoate metabolism_Homo sapiens_hsa00640	2.16284223
11	Protein export_Homo sapiens_hsa03060	2.15463484
12	Base excision repair_Homo sapiens_hsa03410	2.14824078
13	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.07394899
14	Homologous recombination_Homo sapiens_hsa03440	2.07270199
15	Fanconi anemia pathway_Homo sapiens_hsa03460	2.03648296
16	RNA transport_Homo sapiens_hsa03013	2.01447474
17	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.90196897
18	Spliceosome_Homo sapiens_hsa03040	1.89115796
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.85073738
20	Basal transcription factors_Homo sapiens_hsa03022	1.83001456
21	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.80814337
22	RNA polymerase_Homo sapiens_hsa03020	1.77234401
23	RNA degradation_Homo sapiens_hsa03018	1.70223959
24	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.66332308
25	One carbon pool by folate_Homo sapiens_hsa00670	1.64929070
26	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.63214839
27	Pyruvate metabolism_Homo sapiens_hsa00620	1.62220021
28	Parkinsons disease_Homo sapiens_hsa05012	1.61469748
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.58588580
30	Oxidative phosphorylation_Homo sapiens_hsa00190	1.57166043
31	Carbon metabolism_Homo sapiens_hsa01200	1.53367796
32	Nucleotide excision repair_Homo sapiens_hsa03420	1.52368172
33	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.50399842
34	Cell cycle_Homo sapiens_hsa04110	1.48790166
35	Butanoate metabolism_Homo sapiens_hsa00650	1.46619385
36	Fatty acid elongation_Homo sapiens_hsa00062	1.42179906
37	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.35355559
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.34486859
39	Huntingtons disease_Homo sapiens_hsa05016	1.32478799
40	mRNA surveillance pathway_Homo sapiens_hsa03015	1.27972873
41	Selenocompound metabolism_Homo sapiens_hsa00450	1.26814027
42	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.21027277
43	Pyrimidine metabolism_Homo sapiens_hsa00240	1.19244825
44	Nicotine addiction_Homo sapiens_hsa05033	1.11796551
45	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.05152761
46	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.99481794
47	Oocyte meiosis_Homo sapiens_hsa04114	0.98439065
48	Purine metabolism_Homo sapiens_hsa00230	0.95579922
49	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.95320886
50	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.92179389
51	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.88879309
52	Fatty acid metabolism_Homo sapiens_hsa01212	0.87908548
53	Ribosome_Homo sapiens_hsa03010	0.87793559
54	Peroxisome_Homo sapiens_hsa04146	0.86018686
55	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.85133341
56	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.82831357
57	Arginine and proline metabolism_Homo sapiens_hsa00330	0.75238654
58	Alzheimers disease_Homo sapiens_hsa05010	0.75234579
59	Glutathione metabolism_Homo sapiens_hsa00480	0.74994610
60	Metabolic pathways_Homo sapiens_hsa01100	0.72997763
61	Sulfur relay system_Homo sapiens_hsa04122	0.69889920
62	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.66307999
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.65988590
64	Basal cell carcinoma_Homo sapiens_hsa05217	0.57061450
65	Folate biosynthesis_Homo sapiens_hsa00790	0.56982857
66	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.56681547
67	Hippo signaling pathway_Homo sapiens_hsa04390	0.56354793
68	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.53917233
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.53329880
70	Phototransduction_Homo sapiens_hsa04744	0.53160833
71	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.52230330
72	GABAergic synapse_Homo sapiens_hsa04727	0.51775291
73	p53 signaling pathway_Homo sapiens_hsa04115	0.51697136
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.51598046
75	Cardiac muscle contraction_Homo sapiens_hsa04260	0.50835356
76	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.48403758
77	Arginine biosynthesis_Homo sapiens_hsa00220	0.46424388
78	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.42086313
79	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.39433147
80	Nitrogen metabolism_Homo sapiens_hsa00910	0.39151813
81	Lysine degradation_Homo sapiens_hsa00310	0.38558107
82	Fatty acid degradation_Homo sapiens_hsa00071	0.37846671
83	Olfactory transduction_Homo sapiens_hsa04740	0.36103165
84	Ether lipid metabolism_Homo sapiens_hsa00565	0.35505922
85	Taste transduction_Homo sapiens_hsa04742	0.35233783
86	Wnt signaling pathway_Homo sapiens_hsa04310	0.33694474
87	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.33491194
88	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.33455929
89	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.32354986
90	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.30354942
91	Galactose metabolism_Homo sapiens_hsa00052	0.29461571
92	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.25877822
93	Regulation of autophagy_Homo sapiens_hsa04140	0.25150844
94	Retinol metabolism_Homo sapiens_hsa00830	0.24804688
95	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.23663574
96	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.23510326
97	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.23170774
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.23002098
99	Tight junction_Homo sapiens_hsa04530	0.22898947
100	Adherens junction_Homo sapiens_hsa04520	0.21964542

RNASEH1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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