ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	9.83323834
2	chromosome condensation (GO:0030261)	8.92647881
3	plasma membrane fusion (GO:0045026)	8.90669220
4	DNA packaging (GO:0006323)	8.65131785
5	sperm capacitation (GO:0048240)	8.37697007
6	microtubule depolymerization (GO:0007019)	8.32737975
7	single strand break repair (GO:0000012)	8.18099592
8	spermatid nucleus differentiation (GO:0007289)	8.01635575
9	spermatid development (GO:0007286)	7.71303998
10	sperm-egg recognition (GO:0035036)	7.66789197
11	binding of sperm to zona pellucida (GO:0007339)	7.18185029
12	protein polyglutamylation (GO:0018095)	7.15504303
13	microtubule polymerization or depolymerization (GO:0031109)	7.06930866
14	rRNA methylation (GO:0031167)	6.81661271
15	multicellular organism reproduction (GO:0032504)	6.76944846
16	protein targeting to Golgi (GO:0000042)	6.63100807
17	reproduction (GO:0000003)	6.40666817
18	calcium ion-dependent exocytosis (GO:0017156)	6.39814530
19	establishment of protein localization to Golgi (GO:0072600)	6.37988933
20	sexual reproduction (GO:0019953)	6.30114209
21	cell-cell recognition (GO:0009988)	6.25589473
22	axonemal dynein complex assembly (GO:0070286)	6.24663138
23	retrograde transport, vesicle recycling within Golgi (GO:0000301)	6.19604556
24	spermatogenesis (GO:0007283)	6.17313398
25	male gamete generation (GO:0048232)	6.15342277
26	rRNA modification (GO:0000154)	5.90943195
27	centriole replication (GO:0007099)	5.85240137
28	negative regulation of inclusion body assembly (GO:0090084)	5.79085140
29	regulation of cilium movement (GO:0003352)	5.66447526
30	gamete generation (GO:0007276)	5.65995763
31	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.53693288
32	cellular ketone body metabolic process (GO:0046950)	5.34751787
33	microtubule severing (GO:0051013)	5.19092575
34	regulation of centriole replication (GO:0046599)	5.17768939
35	phosphatidylethanolamine metabolic process (GO:0046337)	5.08844908
36	centriole assembly (GO:0098534)	5.01088153
37	regulation of Rab GTPase activity (GO:0032313)	4.98289150
38	positive regulation of Rab GTPase activity (GO:0032851)	4.98289150
39	single fertilization (GO:0007338)	4.84668917
40	protein localization to Golgi apparatus (GO:0034067)	4.76675233
41	cilium or flagellum-dependent cell motility (GO:0001539)	4.73488645
42	ketone body metabolic process (GO:1902224)	4.70769143
43	motile cilium assembly (GO:0044458)	4.63720596
44	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.58659453
45	RNA destabilization (GO:0050779)	4.57563016
46	chromatin silencing (GO:0006342)	4.53859302
47	multicellular organismal reproductive process (GO:0048609)	4.47911486
48	seminiferous tubule development (GO:0072520)	4.47890435
49	germ cell development (GO:0007281)	4.42501474
50	regulation of transcription involved in cell fate commitment (GO:0060850)	4.40837806
51	coenzyme catabolic process (GO:0009109)	4.36244704
52	regulation of inclusion body assembly (GO:0090083)	4.34760999
53	epithelial cilium movement (GO:0003351)	4.34107554
54	glycerol ether metabolic process (GO:0006662)	4.25417551
55	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.22876573
56	fertilization (GO:0009566)	4.21461083
57	cell wall macromolecule catabolic process (GO:0016998)	4.20879908
58	cell wall macromolecule metabolic process (GO:0044036)	4.12341258
59	polyamine biosynthetic process (GO:0006596)	3.96740700
60	nucleus organization (GO:0006997)	3.94273857
61	ether metabolic process (GO:0018904)	3.92145986
62	cilium movement (GO:0003341)	3.72609968
63	multicellular organismal movement (GO:0050879)	3.68132370
64	musculoskeletal movement (GO:0050881)	3.68132370
65	microtubule nucleation (GO:0007020)	3.53125041
66	organic cation transport (GO:0015695)	3.50757828
67	negative regulation of Rho protein signal transduction (GO:0035024)	3.45434979
68	regulation of microtubule-based movement (GO:0060632)	3.44653789
69	glomerular visceral epithelial cell development (GO:0072015)	3.32762895
70	DNA methylation involved in gamete generation (GO:0043046)	3.31678188
71	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.24458547
72	negative regulation of gene expression, epigenetic (GO:0045814)	3.23890896
73	piRNA metabolic process (GO:0034587)	3.21299646
74	nucleosome disassembly (GO:0006337)	3.17710414
75	protein-DNA complex disassembly (GO:0032986)	3.17710414
76	glomerular epithelial cell development (GO:0072310)	3.16684876
77	cerebral cortex neuron differentiation (GO:0021895)	3.16151349
78	male meiosis I (GO:0007141)	3.15400850
79	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.08616592
80	peptidyl-threonine dephosphorylation (GO:0035970)	3.02712593
81	cell recognition (GO:0008037)	3.02679052
82	male meiosis (GO:0007140)	3.02609579
83	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.98798486
84	protein depolymerization (GO:0051261)	2.98467445
85	positive regulation of endothelial cell differentiation (GO:0045603)	2.89823981
86	multicellular organismal development (GO:0007275)	2.87890931
87	response to acidic pH (GO:0010447)	2.83552892
88	regulation of interleukin-13 production (GO:0032656)	2.83404562
89	axoneme assembly (GO:0035082)	2.81706478
90	histone H3-K9 demethylation (GO:0033169)	2.80363610
91	intra-Golgi vesicle-mediated transport (GO:0006891)	2.80321263
92	DNA conformation change (GO:0071103)	2.79731509
93	Golgi to endosome transport (GO:0006895)	2.78909574
94	homeostasis of number of cells within a tissue (GO:0048873)	2.78493481
95	membrane protein intracellular domain proteolysis (GO:0031293)	2.75721464
96	NAD biosynthetic process (GO:0009435)	2.75495977
97	cellular biogenic amine biosynthetic process (GO:0042401)	2.74373543
98	fusion of sperm to egg plasma membrane (GO:0007342)	11.7136850
99	acrosome reaction (GO:0007340)	11.4899291
100	sperm motility (GO:0030317)	11.4166325

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.67978069
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.89976194
3	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.37162870
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.59527573
5	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.58043765
6	CBP_20019798_ChIP-Seq_JUKART_Human	2.42394550
7	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.42394550
8	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.38778847
9	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.38778847
10	FUS_26573619_Chip-Seq_HEK293_Human	2.31532865
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.26231056
12	ERA_21632823_ChIP-Seq_H3396_Human	2.14406785
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.02361267
14	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.99665960
15	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.96360352
16	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.96288642
17	RAC3_21632823_ChIP-Seq_H3396_Human	1.93320545
18	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.91516348
19	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.91077940
20	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.90924695
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.90573021
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.88541963
23	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.83642333
24	NANOG_20526341_ChIP-Seq_ESCs_Human	1.82140366
25	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.81595950
26	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.78176943
27	MYC_19829295_ChIP-Seq_ESCs_Human	1.76336472
28	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.71099857
29	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.68446193
30	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.67398033
31	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.59804160
32	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.59265382
33	DROSHA_22980978_ChIP-Seq_HELA_Human	1.58287279
34	TAF15_26573619_Chip-Seq_HEK293_Human	1.58084986
35	E2F1_20622854_ChIP-Seq_HELA_Human	1.56286791
36	P300_19829295_ChIP-Seq_ESCs_Human	1.55394998
37	TAF2_19829295_ChIP-Seq_ESCs_Human	1.54483436
38	OCT4_20526341_ChIP-Seq_ESCs_Human	1.53066179
39	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.51445550
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.50498989
41	BCL6_27268052_Chip-Seq_Bcells_Human	1.49916276
42	CTCF_27219007_Chip-Seq_Bcells_Human	1.49378250
43	AR_25329375_ChIP-Seq_VCAP_Human	1.46561588
44	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.46245841
45	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.45792402
46	PHF8_20622854_ChIP-Seq_HELA_Human	1.43439505
47	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.43147565
48	RBPJ_21746931_ChIP-Seq_IB4_Human	1.42518231
49	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.42109704
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.40779068
51	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.39035947
52	ERG_20517297_ChIP-Seq_VCAP_Human	1.38799557
53	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.38289478
54	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.38241253
55	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.37572339
56	P68_20966046_ChIP-Seq_HELA_Human	1.35892126
57	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.35823634
58	ETV1_20927104_ChIP-Seq_GIST48_Human	1.35467492
59	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.34141016
60	CTCF_20526341_ChIP-Seq_ESCs_Human	1.33457079
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.32965761
62	BCOR_27268052_Chip-Seq_Bcells_Human	1.32564673
63	SMC4_20622854_ChIP-Seq_HELA_Human	1.31159343
64	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.30932261
65	VDR_22108803_ChIP-Seq_LS180_Human	1.30062412
66	TP53_18474530_ChIP-ChIP_U2OS_Human	1.29574219
67	CEBPB_22108803_ChIP-Seq_LS180_Human	1.28567691
68	P300_27268052_Chip-Seq_Bcells_Human	1.27744627
69	PHF8_20622853_ChIP-Seq_HELA_Human	1.27392157
70	NFYB_21822215_ChIP-Seq_K562_Human	1.26960025
71	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.26509116
72	HOXB7_26014856_ChIP-Seq_BT474_Human	1.26471465
73	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.25356487
74	RUNX2_22187159_ChIP-Seq_PCA_Human	1.25149755
75	P53_21459846_ChIP-Seq_SAOS-2_Human	1.23235832
76	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.20742176
77	TP63_22573176_ChIP-Seq_HFKS_Human	1.20391389
78	TBL1_22424771_ChIP-Seq_293T_Human	1.19896369
79	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.16593575
80	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.15799739
81	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.15601186
82	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.14836642
83	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.14222496
84	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13921139
85	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13342157
86	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13342157
87	AR_21572438_ChIP-Seq_LNCaP_Human	1.13070364
88	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.12445029
89	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.12263073
90	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12030055
91	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.11079014
92	NCOR_22424771_ChIP-Seq_293T_Human	1.09730706
93	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.09423185
94	NFYA_21822215_ChIP-Seq_K562_Human	1.08140511
95	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.06654848
96	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.06654848
97	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.04531411
98	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.04317246
99	SMAD4_21799915_ChIP-Seq_A2780_Human	1.03632587
100	STAT3_23295773_ChIP-Seq_U87_Human	1.03511988

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005377_hearing/vestibular/ear_phenot	4.78890588
2	MP0003878_abnormal_ear_physiology	4.78890588
3	MP0003698_abnormal_male_reproductive	4.19761174
4	MP0005670_abnormal_white_adipose	3.91796849
5	MP0001929_abnormal_gametogenesis	3.65339105
6	MP0001348_abnormal_lacrimal_gland	3.13265488
7	MP0003718_maternal_effect	2.72640619
8	MP0000678_abnormal_parathyroid_gland	2.60529623
9	MP0003646_muscle_fatigue	2.36957200
10	MP0002161_abnormal_fertility/fecundity	2.29121768
11	MP0003011_delayed_dark_adaptation	2.26837184
12	MP0002132_abnormal_respiratory_system	2.04023122
13	MP0005410_abnormal_fertilization	11.0659449
14	MP0005379_endocrine/exocrine_gland_phen	1.88098304
15	MP0008877_abnormal_DNA_methylation	1.87473782
16	MP0002249_abnormal_larynx_morphology	1.82392978
17	MP0002210_abnormal_sex_determination	1.71870851
18	MP0001486_abnormal_startle_reflex	1.70806162
19	MP0005083_abnormal_biliary_tract	1.63443119
20	MP0002234_abnormal_pharynx_morphology	1.59061101
21	MP0005423_abnormal_somatic_nervous	1.53658572
22	MP0001968_abnormal_touch/_nociception	1.47952091
23	MP0001485_abnormal_pinna_reflex	1.44381107
24	MP0001145_abnormal_male_reproductive	1.42708760
25	MP0002282_abnormal_trachea_morphology	1.40001036
26	MP0000653_abnormal_sex_gland	1.37240622
27	MP0002822_catalepsy	1.36432233
28	MP0009053_abnormal_anal_canal	1.25472270
29	MP0004859_abnormal_synaptic_plasticity	1.20129510
30	MP0000049_abnormal_middle_ear	1.20001746
31	MP0005248_abnormal_Harderian_gland	1.19744232
32	MP0002138_abnormal_hepatobiliary_system	1.19579081
33	MP0009697_abnormal_copulation	1.17490119
34	MP0001963_abnormal_hearing_physiology	1.17235246
35	MP0006292_abnormal_olfactory_placode	1.16918303
36	MP0004742_abnormal_vestibular_system	1.13423750
37	MP0000026_abnormal_inner_ear	1.12050718
38	MP0005253_abnormal_eye_physiology	1.11303257
39	MP0005310_abnormal_salivary_gland	1.11024072
40	MP0002127_abnormal_cardiovascular_syste	1.07541534
41	MP0002735_abnormal_chemical_nociception	1.07526814
42	MP0005551_abnormal_eye_electrophysiolog	1.04640792
43	MP0008789_abnormal_olfactory_epithelium	1.03183213
44	MP0005395_other_phenotype	1.00403275
45	MP0005167_abnormal_blood-brain_barrier	0.99117132
46	MP0001984_abnormal_olfaction	0.97523958
47	MP0003880_abnormal_central_pattern	0.96114517
48	MP0002229_neurodegeneration	0.93685818
49	MP0001765_abnormal_ion_homeostasis	0.91537903
50	MP0002733_abnormal_thermal_nociception	0.90780905
51	MP0000955_abnormal_spinal_cord	0.89661922
52	MP0003879_abnormal_hair_cell	0.88991420
53	MP0004510_myositis	0.88404885
54	MP0002067_abnormal_sensory_capabilities	0.85303709
55	MP0005394_taste/olfaction_phenotype	0.83622563
56	MP0005499_abnormal_olfactory_system	0.83622563
57	MP0002653_abnormal_ependyma_morphology	0.82427801
58	MP0005084_abnormal_gallbladder_morpholo	0.81531871
59	MP0002736_abnormal_nociception_after	0.81363365
60	MP0001529_abnormal_vocalization	0.80641596
61	MP0004085_abnormal_heartbeat	0.80510755
62	MP0008995_early_reproductive_senescence	0.80021112
63	MP0000534_abnormal_ureter_morphology	0.79237029
64	MP0002557_abnormal_social/conspecific_i	0.78497621
65	MP0001905_abnormal_dopamine_level	0.75452569
66	MP0008569_lethality_at_weaning	0.74887272
67	MP0002572_abnormal_emotion/affect_behav	0.73120090
68	MP0005636_abnormal_mineral_homeostasis	0.72568103
69	MP0009745_abnormal_behavioral_response	0.70797827
70	MP0003119_abnormal_digestive_system	0.68830564
71	MP0002272_abnormal_nervous_system	0.68468373
72	MP0005085_abnormal_gallbladder_physiolo	0.67231720
73	MP0002734_abnormal_mechanical_nocicepti	0.67130377
74	MP0004270_analgesia	0.64278616
75	MP0003137_abnormal_impulse_conducting	0.64270088
76	MP0006276_abnormal_autonomic_nervous	0.64169748
77	MP0002102_abnormal_ear_morphology	0.62869241
78	MP0002254_reproductive_system_inflammat	0.62848739
79	MP0000681_abnormal_thyroid_gland	0.59514498
80	MP0001970_abnormal_pain_threshold	0.59397741
81	MP0000516_abnormal_urinary_system	0.55983042
82	MP0005367_renal/urinary_system_phenotyp	0.55983042
83	MP0005391_vision/eye_phenotype	0.54084346
84	MP0005451_abnormal_body_composition	0.52705140
85	MP0003077_abnormal_cell_cycle	0.51605392
86	MP0009115_abnormal_fat_cell	0.51284423
87	MP0004084_abnormal_cardiac_muscle	0.49114317
88	MP0003635_abnormal_synaptic_transmissio	0.48475423
89	MP0005645_abnormal_hypothalamus_physiol	0.47895195
90	MP0001270_distended_abdomen	0.47493627
91	MP0002928_abnormal_bile_duct	0.46975839
92	MP0002184_abnormal_innervation	0.46706193
93	MP0002752_abnormal_somatic_nervous	0.46351013
94	MP0004484_altered_response_of	0.46315656
95	MP0002882_abnormal_neuron_morphology	0.44914849
96	MP0001501_abnormal_sleep_pattern	0.44843105
97	MP0001293_anophthalmia	0.44810586
98	MP0005332_abnormal_amino_acid	0.40060277
99	MP0003693_abnormal_embryo_hatching	0.39321198
100	MP0005365_abnormal_bile_salt	0.38509390

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	8.02858446
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.78887333
3	Absent/shortened dynein arms (HP:0200106)	5.78887333
4	Attenuation of retinal blood vessels (HP:0007843)	5.06558128
5	Bony spicule pigmentary retinopathy (HP:0007737)	4.72098952
6	Asymmetric septal hypertrophy (HP:0001670)	4.66961400
7	Tubulointerstitial nephritis (HP:0001970)	4.63952483
8	Abnormal ciliary motility (HP:0012262)	4.58308838
9	Chronic hepatic failure (HP:0100626)	4.57534321
10	Abnormal respiratory motile cilium physiology (HP:0012261)	4.48336612
11	Abnormal respiratory epithelium morphology (HP:0012253)	4.29187761
12	Abnormal respiratory motile cilium morphology (HP:0005938)	4.29187761
13	Bell-shaped thorax (HP:0001591)	4.18986350
14	Abnormal rod and cone electroretinograms (HP:0008323)	3.96115899
15	Resting tremor (HP:0002322)	3.85630482
16	Male infertility (HP:0003251)	3.85404899
17	Abnormality of macular pigmentation (HP:0008002)	3.81523574
18	Infertility (HP:0000789)	3.80950467
19	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.80207208
20	Potter facies (HP:0002009)	3.70952054
21	Facial shape deformation (HP:0011334)	3.70952054
22	Enlarged epiphyses (HP:0010580)	3.54304776
23	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.53912380
24	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.53489059
25	Hypoplastic ischia (HP:0003175)	3.50439548
26	Hyperkalemia (HP:0002153)	3.38726235
27	Nephronophthisis (HP:0000090)	3.35359984
28	Impulsivity (HP:0100710)	3.33220857
29	Nasal polyposis (HP:0100582)	3.29955430
30	Abnormal spermatogenesis (HP:0008669)	3.25321064
31	Cone-rod dystrophy (HP:0000548)	3.20597511
32	Azoospermia (HP:0000027)	3.15176165
33	Abnormality of the ischium (HP:0003174)	3.09237826
34	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.08085317
35	Abnormality of the renal medulla (HP:0100957)	2.91046003
36	Stage 5 chronic kidney disease (HP:0003774)	2.84195371
37	Abnormal urine output (HP:0012590)	2.81225448
38	Rhinitis (HP:0012384)	2.73099605
39	Generalized aminoaciduria (HP:0002909)	2.73079914
40	Hypoplasia of the thymus (HP:0000778)	2.67446021
41	Abnormality of dental color (HP:0011073)	2.66915952
42	Amelogenesis imperfecta (HP:0000705)	2.65479953
43	Abnormal drinking behavior (HP:0030082)	2.60761201
44	Polydipsia (HP:0001959)	2.60761201
45	Abnormality of the nasal mucosa (HP:0000433)	2.57334219
46	Renal dysplasia (HP:0000110)	2.53120332
47	Tubulointerstitial abnormality (HP:0001969)	2.52066175
48	Optic nerve hypoplasia (HP:0000609)	2.51550402
49	Progressive cerebellar ataxia (HP:0002073)	2.47594866
50	Abnormality of the aortic arch (HP:0012303)	2.45700599
51	Menstrual irregularities (HP:0000858)	2.42699736
52	Postural instability (HP:0002172)	2.42067645
53	Polyuria (HP:0000103)	2.41362469
54	Unilateral renal agenesis (HP:0000122)	2.40412725
55	Abnormality of renal excretion (HP:0011036)	2.40304642
56	Hypophosphatemic rickets (HP:0004912)	2.39855329
57	Truncal obesity (HP:0001956)	2.37534299
58	Congenital malformation of the right heart (HP:0011723)	2.35904247
59	Double outlet right ventricle (HP:0001719)	2.35904247
60	Progressive sensorineural hearing impairment (HP:0000408)	2.34823629
61	Hypoalphalipoproteinemia (HP:0003233)	2.33345168
62	Portal hypertension (HP:0001409)	2.32110324
63	Insulin-resistant diabetes mellitus (HP:0000831)	2.29411631
64	Osteomalacia (HP:0002749)	2.25864860
65	Abnormality of the costochondral junction (HP:0000919)	2.19976192
66	Renal Fanconi syndrome (HP:0001994)	2.19815928
67	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.16921976
68	Pancreatic fibrosis (HP:0100732)	2.16254069
69	Abnormality of potassium homeostasis (HP:0011042)	2.15863595
70	Upper limb muscle weakness (HP:0003484)	2.14812584
71	Intellectual disability, moderate (HP:0002342)	2.12611626
72	Abnormality of the hepatic vasculature (HP:0006707)	2.10581398
73	Pendular nystagmus (HP:0012043)	2.08702865
74	Occipital encephalocele (HP:0002085)	2.05217302
75	Widely patent fontanelles and sutures (HP:0004492)	2.03929004
76	Pancreatic cysts (HP:0001737)	2.02688877
77	Decreased central vision (HP:0007663)	1.98420864
78	Absent epiphyses (HP:0010577)	1.97938275
79	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.97938275
80	Abnormality of the parathyroid morphology (HP:0011766)	1.96547174
81	Chronic bronchitis (HP:0004469)	1.96024379
82	Renovascular hypertension (HP:0100817)	1.94775175
83	Muscle fiber atrophy (HP:0100295)	1.94582887
84	Abnormality of the pubic bones (HP:0003172)	1.94237233
85	Ventricular tachycardia (HP:0004756)	1.94101195
86	Failure to thrive in infancy (HP:0001531)	1.86606639
87	Tubular atrophy (HP:0000092)	1.86020729
88	Spastic paraparesis (HP:0002313)	1.85809658
89	Bronchiectasis (HP:0002110)	1.83135398
90	Peripheral hypomyelination (HP:0007182)	1.82776439
91	Hyperuricemia (HP:0002149)	1.81899794
92	Increased purine levels (HP:0004368)	1.81899794
93	Retinal dysplasia (HP:0007973)	1.79858596
94	Glycosuria (HP:0003076)	1.78616532
95	Abnormality of urine glucose concentration (HP:0011016)	1.78616532
96	Myokymia (HP:0002411)	1.77004302
97	Horizontal nystagmus (HP:0000666)	1.73722817
98	Hyponatremia (HP:0002902)	1.73402310
99	Mixed hearing impairment (HP:0000410)	1.72802484
100	Type 2 muscle fiber atrophy (HP:0003554)	1.71617275

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	8.60884404
2	TESK1	5.43814606
3	MAP4K2	4.49821531
4	DDR2	4.49615189
5	INSRR	4.14378736
6	PLK2	3.79500149
7	BRD4	3.02564611
8	PNCK	2.58163420
9	STK38	2.31892060
10	STK38L	2.29270386
11	PIK3CG	1.89584124
12	CAMK1G	1.86857562
13	MAPK15	1.71937556
14	DYRK1B	1.64555014
15	PRKD3	1.62225420
16	MAP3K9	1.36641567
17	WNK1	1.29120376
18	PTK2B	1.25777316
19	PDK1	1.17946025
20	CDK7	1.16903420
21	ARAF	1.15374232
22	PDPK1	1.11513343
23	MST1R	1.09558122
24	MAP3K4	1.03690320
25	TRIM28	0.99470606
26	MAP2K7	0.90506829
27	NEK6	0.89826606
28	MARK1	0.88359291
29	BRAF	0.87945221
30	PRKG2	0.77626822
31	ZAK	0.74569056
32	PIM2	0.73045841
33	KSR2	0.72692119
34	TYRO3	0.72048019
35	ADRBK2	0.64933415
36	RPS6KA2	0.59836861
37	UHMK1	0.59655023
38	PRKG1	0.59474724
39	BMPR1B	0.59458482
40	SRPK1	0.59066502
41	CDK12	0.58034334
42	TESK2	0.56366788
43	PRKAA2	0.56306354
44	PRKCG	0.54906012
45	RPS6KA1	0.54410001
46	SIK2	0.54182509
47	LATS2	0.53191412
48	CAMK1D	0.51579955
49	CAMK1	0.50695273
50	CAMK4	0.49008081
51	TAOK3	0.48908342
52	CDK3	0.48161668
53	TIE1	0.47592164
54	AKT3	0.47586111
55	DYRK3	0.46086730
56	CDK2	0.43315480
57	MAP3K7	0.40960215
58	MAP2K2	0.40945351
59	EPHA4	0.38850756
60	GSK3B	0.38104066
61	NTRK3	0.37742976
62	CDK1	0.37305830
63	PKN1	0.36671747
64	PRKCE	0.36164061
65	LMTK2	0.36036693
66	ROCK1	0.33969813
67	OXSR1	0.33054033
68	VRK1	0.32835204
69	WNK3	0.32827053
70	GRK1	0.32552367
71	DYRK2	0.32550653
72	RPS6KA6	0.31490128
73	CHEK1	0.31106732
74	RPS6KL1	0.31105982
75	RPS6KC1	0.31105982
76	PRKCZ	0.30920030
77	MUSK	0.30212615
78	WNK4	0.30180631
79	MAPK1	0.29802256
80	MAP3K8	0.28730231
81	BCR	0.28102161
82	MAP3K11	0.27993418
83	PRKCB	0.24721732
84	PLK1	0.24286825
85	BRSK1	0.23164269
86	MAPK8	0.22419470
87	FRK	0.22174394
88	MAPK10	0.20494777
89	NUAK1	0.20142006
90	CDK19	0.18848825
91	STK39	0.18753319
92	SGK223	0.18716773
93	SGK494	0.18716773
94	MAP3K2	0.18607987
95	MAPK14	0.18018403
96	NME1	0.17865548
97	MAPK11	0.16037793
98	PRKACA	0.15549942
99	CDK4	0.14111897
100	MET	0.13629574

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	7.91424990
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.17839208
3	Olfactory transduction_Homo sapiens_hsa04740	4.00900225
4	Butanoate metabolism_Homo sapiens_hsa00650	3.25574826
5	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.36545250
6	RNA transport_Homo sapiens_hsa03013	2.12049956
7	Taste transduction_Homo sapiens_hsa04742	1.80199016
8	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.79224836
9	Fatty acid degradation_Homo sapiens_hsa00071	1.69447251
10	Fatty acid metabolism_Homo sapiens_hsa01212	1.64234734
11	Arginine and proline metabolism_Homo sapiens_hsa00330	1.57790337
12	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.56508561
13	Phototransduction_Homo sapiens_hsa04744	1.55426996
14	Type II diabetes mellitus_Homo sapiens_hsa04930	1.52359737
15	Nicotine addiction_Homo sapiens_hsa05033	1.50356909
16	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.46774742
17	Type I diabetes mellitus_Homo sapiens_hsa04940	1.41908857
18	Phenylalanine metabolism_Homo sapiens_hsa00360	1.37904916
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.32475218
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.32438966
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.26416111
22	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.18440905
23	Allograft rejection_Homo sapiens_hsa05330	1.17758508
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.13777458
25	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.11379648
26	Antigen processing and presentation_Homo sapiens_hsa04612	1.07564344
27	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.07210965
28	Graft-versus-host disease_Homo sapiens_hsa05332	1.06643106
29	Fat digestion and absorption_Homo sapiens_hsa04975	1.05929716
30	Morphine addiction_Homo sapiens_hsa05032	1.05710469
31	Arginine biosynthesis_Homo sapiens_hsa00220	1.03711013
32	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.01232795
33	Basal transcription factors_Homo sapiens_hsa03022	0.98510207
34	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.98215957
35	Salivary secretion_Homo sapiens_hsa04970	0.96791973
36	Oocyte meiosis_Homo sapiens_hsa04114	0.96789097
37	beta-Alanine metabolism_Homo sapiens_hsa00410	0.96162452
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.92342405
39	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.90067402
40	Huntingtons disease_Homo sapiens_hsa05016	0.89875383
41	Purine metabolism_Homo sapiens_hsa00230	0.88885486
42	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.88086038
43	Retinol metabolism_Homo sapiens_hsa00830	0.84542026
44	Renin-angiotensin system_Homo sapiens_hsa04614	0.83994812
45	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.83696582
46	Protein digestion and absorption_Homo sapiens_hsa04974	0.80740901
47	ABC transporters_Homo sapiens_hsa02010	0.78938727
48	Viral myocarditis_Homo sapiens_hsa05416	0.78918855
49	Fanconi anemia pathway_Homo sapiens_hsa03460	0.78794327
50	Circadian entrainment_Homo sapiens_hsa04713	0.76219013
51	Tyrosine metabolism_Homo sapiens_hsa00350	0.76217932
52	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.76095738
53	Endocytosis_Homo sapiens_hsa04144	0.76085076
54	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.72688497
55	Glycerolipid metabolism_Homo sapiens_hsa00561	0.71614306
56	Sulfur relay system_Homo sapiens_hsa04122	0.70832136
57	Base excision repair_Homo sapiens_hsa03410	0.70249839
58	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.67691476
59	GABAergic synapse_Homo sapiens_hsa04727	0.64669233
60	cAMP signaling pathway_Homo sapiens_hsa04024	0.64118246
61	Propanoate metabolism_Homo sapiens_hsa00640	0.63407237
62	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.62989668
63	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.62200136
64	Calcium signaling pathway_Homo sapiens_hsa04020	0.61156973
65	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.59350870
66	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.58895420
67	mRNA surveillance pathway_Homo sapiens_hsa03015	0.58532698
68	PPAR signaling pathway_Homo sapiens_hsa03320	0.57132722
69	Nitrogen metabolism_Homo sapiens_hsa00910	0.57117335
70	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.55393378
71	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.54573842
72	Glutamatergic synapse_Homo sapiens_hsa04724	0.54033158
73	Gastric acid secretion_Homo sapiens_hsa04971	0.50983499
74	Alcoholism_Homo sapiens_hsa05034	0.48178028
75	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.48140747
76	Bile secretion_Homo sapiens_hsa04976	0.45870637
77	Metabolic pathways_Homo sapiens_hsa01100	0.45079551
78	Serotonergic synapse_Homo sapiens_hsa04726	0.44764958
79	RNA polymerase_Homo sapiens_hsa03020	0.43412140
80	Insulin secretion_Homo sapiens_hsa04911	0.43349618
81	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.41400548
82	Linoleic acid metabolism_Homo sapiens_hsa00591	0.39287633
83	Peroxisome_Homo sapiens_hsa04146	0.38885220
84	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.38742597
85	Carbon metabolism_Homo sapiens_hsa01200	0.37750704
86	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.36735239
87	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.36172314
88	Tryptophan metabolism_Homo sapiens_hsa00380	0.33347463
89	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.32863243
90	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.32608602
91	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.31579952
92	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.30771567
93	Tight junction_Homo sapiens_hsa04530	0.29779664
94	Renin secretion_Homo sapiens_hsa04924	0.28338845
95	Influenza A_Homo sapiens_hsa05164	0.25487039
96	Chemical carcinogenesis_Homo sapiens_hsa05204	0.25417084
97	Viral carcinogenesis_Homo sapiens_hsa05203	0.25030793
98	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.23466684
99	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.19113186
100	Homologous recombination_Homo sapiens_hsa03440	0.19035521

RNASEH1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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