RNASEH2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm-egg recognition (GO:0035036)6.30359643
2fusion of sperm to egg plasma membrane (GO:0007342)6.20925453
3binding of sperm to zona pellucida (GO:0007339)6.13247886
4sperm motility (GO:0030317)6.08340885
5cell wall macromolecule metabolic process (GO:0044036)5.73538780
6cell wall macromolecule catabolic process (GO:0016998)5.73538780
7cell-cell recognition (GO:0009988)5.58650836
8acrosome assembly (GO:0001675)5.41979202
9acrosome reaction (GO:0007340)5.24193838
10spermatid development (GO:0007286)4.95100795
11multicellular organism reproduction (GO:0032504)4.90634141
12cilium or flagellum-dependent cell motility (GO:0001539)4.85678674
13establishment of integrated proviral latency (GO:0075713)4.79923884
14axonemal dynein complex assembly (GO:0070286)4.78491242
15motile cilium assembly (GO:0044458)4.71153539
16DNA deamination (GO:0045006)4.66640937
17plasma membrane fusion (GO:0045026)4.54761540
18ribosomal small subunit assembly (GO:0000028)4.47655829
19epithelial cilium movement (GO:0003351)4.39008517
20synaptonemal complex assembly (GO:0007130)4.37348882
21piRNA metabolic process (GO:0034587)4.36538775
22synaptonemal complex organization (GO:0070193)4.30109217
23regulation of cilium movement (GO:0003352)4.29902156
24microtubule depolymerization (GO:0007019)4.26086697
25DNA strand elongation involved in DNA replication (GO:0006271)4.24503399
26male meiosis (GO:0007140)4.16223924
27reproduction (GO:0000003)4.06736216
28telomere maintenance via semi-conservative replication (GO:0032201)4.05448980
29DNA strand elongation (GO:0022616)4.04421177
30mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.02146683
31DNA replication initiation (GO:0006270)3.97503480
32establishment of viral latency (GO:0019043)3.93972885
33mitotic chromosome condensation (GO:0007076)3.93581701
34proteasome assembly (GO:0043248)3.93081542
35chromosome condensation (GO:0030261)3.86132363
36regulation of mitochondrial translation (GO:0070129)3.84458165
37DNA replication-dependent nucleosome assembly (GO:0006335)3.84301042
38DNA replication-dependent nucleosome organization (GO:0034723)3.84301042
39sister chromatid segregation (GO:0000819)3.82040371
40DNA packaging (GO:0006323)3.81888529
41establishment of protein localization to mitochondrial membrane (GO:0090151)3.81310846
42maturation of SSU-rRNA (GO:0030490)3.81026333
43histone exchange (GO:0043486)3.72162403
44kinetochore assembly (GO:0051382)3.69156560
45negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.69071826
46telomere maintenance via recombination (GO:0000722)3.65669783
47protein localization to chromosome, centromeric region (GO:0071459)3.64832630
48energy coupled proton transport, down electrochemical gradient (GO:0015985)3.59367809
49ATP synthesis coupled proton transport (GO:0015986)3.59367809
50DNA ligation (GO:0006266)3.59051026
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.56338453
52chromatin remodeling at centromere (GO:0031055)3.54950911
53chromosome organization involved in meiosis (GO:0070192)3.52677772
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.51593397
55single fertilization (GO:0007338)3.49942414
56viral transcription (GO:0019083)3.45164798
57DNA replication checkpoint (GO:0000076)3.44560007
58negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.40762139
59negative regulation of ligase activity (GO:0051352)3.40762139
60epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.39828010
61cilium movement (GO:0003341)3.39376476
62mitotic recombination (GO:0006312)3.38956983
63chaperone-mediated protein transport (GO:0072321)3.37887718
64single strand break repair (GO:0000012)3.37781011
65translational termination (GO:0006415)3.36358126
66metaphase plate congression (GO:0051310)3.35932616
67CENP-A containing nucleosome assembly (GO:0034080)3.33329788
68positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.33189330
69spermatogenesis (GO:0007283)3.32436883
70male gamete generation (GO:0048232)3.32254442
71meiotic nuclear division (GO:0007126)3.29784338
72L-serine metabolic process (GO:0006563)3.28122984
73transcription-coupled nucleotide-excision repair (GO:0006283)3.28030823
74chaperone-mediated protein complex assembly (GO:0051131)3.26205350
75translational elongation (GO:0006414)3.25430510
76male meiosis I (GO:0007141)3.25231590
77DNA unwinding involved in DNA replication (GO:0006268)3.22317813
78sequestering of actin monomers (GO:0042989)3.21041751
79nucleotide-excision repair, DNA gap filling (GO:0006297)3.20116952
80heterochromatin organization (GO:0070828)3.19607452
81establishment of protein localization to endoplasmic reticulum (GO:0072599)3.18807807
82regulation of spindle checkpoint (GO:0090231)3.18453519
83ribosomal large subunit biogenesis (GO:0042273)3.18340740
84base-excision repair (GO:0006284)3.17344423
85ribosomal small subunit biogenesis (GO:0042274)3.17251247
86nuclear pore organization (GO:0006999)3.16800488
87nucleobase biosynthetic process (GO:0046112)3.13708263
88protein localization to endoplasmic reticulum (GO:0070972)3.13334416
89chromatin assembly or disassembly (GO:0006333)3.10933301
90mitotic nuclear envelope disassembly (GO:0007077)3.10244809
91purine nucleobase biosynthetic process (GO:0009113)3.10113532
92fertilization (GO:0009566)3.09423851
93telomere maintenance via telomere lengthening (GO:0010833)3.09191385
94IMP biosynthetic process (GO:0006188)3.08526878
95translation (GO:0006412)3.07061124
96regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.06893640
97DNA replication-independent nucleosome assembly (GO:0006336)3.05202146
98DNA replication-independent nucleosome organization (GO:0034724)3.05202146
99replication fork processing (GO:0031297)3.05067785
100meiosis I (GO:0007127)3.04722583
101gamete generation (GO:0007276)3.03868412
102DNA strand renaturation (GO:0000733)3.03053750
103viral life cycle (GO:0019058)3.03036697
104spliceosomal snRNP assembly (GO:0000387)3.01590469
105formation of translation preinitiation complex (GO:0001731)3.00948230
106DNA methylation involved in gamete generation (GO:0043046)2.99819799
107DNA damage response, detection of DNA damage (GO:0042769)2.99774888
108nuclear pore complex assembly (GO:0051292)2.99724736
109pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.99067413
110sperm capacitation (GO:0048240)2.98437597
111pseudouridine synthesis (GO:0001522)2.98092539
112negative regulation of chromosome segregation (GO:0051985)2.97197906
113spindle checkpoint (GO:0031577)2.96929119
114cell cycle G1/S phase transition (GO:0044843)2.96730857
115G1/S transition of mitotic cell cycle (GO:0000082)2.96730857
116rRNA processing (GO:0006364)2.96032246
117regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.95928170
118termination of RNA polymerase III transcription (GO:0006386)2.94474940
119transcription elongation from RNA polymerase III promoter (GO:0006385)2.94474940
120meiotic cell cycle (GO:0051321)2.94195027
121nucleobase-containing small molecule interconversion (GO:0015949)2.93496919
122positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.93268681
123pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.92957301
124pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.92182777
125translational initiation (GO:0006413)2.91298634
126mitochondrial respiratory chain complex assembly (GO:0033108)2.90915737
127chromosome segregation (GO:0007059)2.90690272
128protein localization to kinetochore (GO:0034501)2.90649982
129signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.90596784
130signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.90596784
131signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.90596784
132translesion synthesis (GO:0019985)2.90516120
133negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.90325603
134negative regulation of mitotic sister chromatid segregation (GO:0033048)2.90325603
135negative regulation of mitotic sister chromatid separation (GO:2000816)2.90325603
136negative regulation of sister chromatid segregation (GO:0033046)2.90325603
137germ cell development (GO:0007281)2.90291824
138GTP biosynthetic process (GO:0006183)2.90089882
139ribonucleoprotein complex biogenesis (GO:0022613)2.89739990
140mitotic metaphase plate congression (GO:0007080)2.88880377
141nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.88716735
142pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.88374105
143SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.87769469
144UTP biosynthetic process (GO:0006228)2.87745516
145mitotic sister chromatid segregation (GO:0000070)2.86508729
146membrane disassembly (GO:0030397)2.83633215
147nuclear envelope disassembly (GO:0051081)2.83633215
148DNA conformation change (GO:0071103)2.82721309
149deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.81907341
150kinetochore organization (GO:0051383)2.81585459
151cellular protein complex disassembly (GO:0043624)2.80993506
152cotranslational protein targeting to membrane (GO:0006613)2.78199174
153protein targeting to ER (GO:0045047)2.77598123
154cellular process involved in reproduction in multicellular organism (GO:0022412)2.76957978
155guanosine-containing compound biosynthetic process (GO:1901070)2.76683167
156ribosome biogenesis (GO:0042254)2.75879809

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.35290949
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.07746875
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.70715988
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.40914218
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.35021742
6* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.15393258
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91656318
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80093879
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.75545785
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.72585582
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.66297326
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59535601
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.52436610
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.48150532
15* ETS1_20019798_ChIP-Seq_JURKAT_Human2.45189814
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.38054958
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.37475378
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.31573338
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.26763444
20XRN2_22483619_ChIP-Seq_HELA_Human2.12449886
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11231449
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.08490931
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05917208
24VDR_23849224_ChIP-Seq_CD4+_Human2.04763976
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00467601
26ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.88001585
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85550456
28* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84535531
29FOXP3_21729870_ChIP-Seq_TREG_Human1.82641937
30DCP1A_22483619_ChIP-Seq_HELA_Human1.81854259
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.76663641
32GABP_19822575_ChIP-Seq_HepG2_Human1.68113483
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67370113
34CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.66069361
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65616527
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64873592
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63112143
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60711753
39* TTF2_22483619_ChIP-Seq_HELA_Human1.60679341
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60038938
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53629520
42* E2F1_21310950_ChIP-Seq_MCF-7_Human1.52810784
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52581239
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49363897
45* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48811584
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.48358592
47AR_21909140_ChIP-Seq_LNCAP_Human1.47452410
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35373532
49* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34487979
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28845587
51SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28500405
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22874402
53KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21978234
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21916339
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21696775
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20827714
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18889319
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17799394
59* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17581771
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15622840
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13364414
62KDM5A_27292631_Chip-Seq_BREAST_Human1.13248683
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10262909
64ELK1_19687146_ChIP-ChIP_HELA_Human1.10119337
65CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07369466
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07213742
67HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05167646
68* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04861314
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04715910
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04684990
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04069371
72SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03590133
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02236841
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01647720
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01564266
76CIITA_25753668_ChIP-Seq_RAJI_Human1.01553726
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01241142
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.01221141
79SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00969458
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00926011
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98927652
82TP63_19390658_ChIP-ChIP_HaCaT_Human0.98922268
83* YY1_22570637_ChIP-Seq_MALME-3M_Human0.97885647
84ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96636862
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96385365
86CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93964273
87NANOG_16153702_ChIP-ChIP_HESCs_Human0.93811862
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91189116
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90534178
90* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90512822
91KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89779005
92GATA3_21867929_ChIP-Seq_CD8_Mouse0.88329712
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88207363
94SOX17_20123909_ChIP-Seq_XEN_Mouse0.86713455
95MYC_22102868_ChIP-Seq_BL_Human0.85696887
96TET1_21451524_ChIP-Seq_MESCs_Mouse0.85264666
97SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84821809
98MYC_18940864_ChIP-ChIP_HL60_Human0.84784723
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82003602
100SPI1_23547873_ChIP-Seq_NB4_Human0.81504540
101SOX2_22085726_ChIP-Seq_NPCs_Mouse0.79475449
102PADI4_21655091_ChIP-ChIP_MCF-7_Human0.79371951
103PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79276439
104* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78499961
105POU5F1_16153702_ChIP-ChIP_HESCs_Human0.78211918
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.77888420
107ELK1_22589737_ChIP-Seq_MCF10A_Human0.77612115
108CTCF_26484167_Chip-Seq_Bcells_Mouse0.77561724
109* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77296538
110ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.76890072
111* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.76819492
112HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76250522
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75956003
114* ELF1_20517297_ChIP-Seq_JURKAT_Human0.75781148
115SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75359684
116GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75038634
117IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.74703277
118OCT4_18692474_ChIP-Seq_MEFs_Mouse0.74656697
119TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.74132430
120TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74118079
121IRF1_19129219_ChIP-ChIP_H3396_Human0.73374479
122FOXP1_21924763_ChIP-Seq_HESCs_Human0.73353503
123* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.73334832
124MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.72748723

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.35284420
2MP0010094_abnormal_chromosome_stability4.16202052
3MP0003693_abnormal_embryo_hatching4.05565718
4MP0008877_abnormal_DNA_methylation3.73493417
5MP0003111_abnormal_nucleus_morphology3.69340823
6MP0001929_abnormal_gametogenesis3.61630965
7MP0008058_abnormal_DNA_repair3.49870073
8MP0003698_abnormal_male_reproductive3.48634657
9MP0008057_abnormal_DNA_replication3.44888881
10MP0003077_abnormal_cell_cycle3.29397638
11MP0004957_abnormal_blastocyst_morpholog3.23010134
12MP0002210_abnormal_sex_determination2.84987687
13MP0008007_abnormal_cellular_replicative2.62225360
14MP0001145_abnormal_male_reproductive2.39626662
15MP0008932_abnormal_embryonic_tissue2.12870819
16MP0000653_abnormal_sex_gland2.05878472
17MP0002160_abnormal_reproductive_system2.05061693
18MP0002161_abnormal_fertility/fecundity1.98767289
19MP0003786_premature_aging1.91832511
20MP0002938_white_spotting1.85373823
21MP0002396_abnormal_hematopoietic_system1.76904631
22MP0003136_yellow_coat_color1.74558841
23MP0002653_abnormal_ependyma_morphology1.73829354
24MP0001730_embryonic_growth_arrest1.67228102
25MP0009697_abnormal_copulation1.61992845
26MP0005397_hematopoietic_system_phenotyp1.54436956
27MP0001545_abnormal_hematopoietic_system1.54436956
28MP0003646_muscle_fatigue1.52308845
29MP0000350_abnormal_cell_proliferation1.49763924
30MP0008789_abnormal_olfactory_epithelium1.47832390
31MP0003806_abnormal_nucleotide_metabolis1.46367486
32MP0003937_abnormal_limbs/digits/tail_de1.46067476
33MP0000490_abnormal_crypts_of1.45546814
34MP0000313_abnormal_cell_death1.41558841
35MP0001529_abnormal_vocalization1.40242714
36MP0004808_abnormal_hematopoietic_stem1.36126843
37MP0002132_abnormal_respiratory_system1.35231307
38MP0000372_irregular_coat_pigmentation1.29815435
39MP0002234_abnormal_pharynx_morphology1.28626452
40MP0005389_reproductive_system_phenotype1.25934196
41MP0003123_paternal_imprinting1.25823692
42MP0002697_abnormal_eye_size1.25651016
43MP0000049_abnormal_middle_ear1.23806626
44MP0001346_abnormal_lacrimal_gland1.23083564
45MP0000537_abnormal_urethra_morphology1.22062187
46MP0010307_abnormal_tumor_latency1.19783953
47MP0009672_abnormal_birth_weight1.18626097
48MP0002019_abnormal_tumor_incidence1.17649210
49MP0005075_abnormal_melanosome_morpholog1.17171031
50MP0005380_embryogenesis_phenotype1.15890581
51MP0001672_abnormal_embryogenesis/_devel1.15890581
52MP0001697_abnormal_embryo_size1.15854280
53MP0005394_taste/olfaction_phenotype1.15508839
54MP0005499_abnormal_olfactory_system1.15508839
55MP0003186_abnormal_redox_activity1.14874156
56MP0002080_prenatal_lethality1.13782100
57MP0001853_heart_inflammation1.12617719
58MP0010352_gastrointestinal_tract_polyps1.10093627
59MP0001293_anophthalmia1.09289839
60MP0000358_abnormal_cell_content/1.08946481
61MP0004133_heterotaxia1.08784494
62MP0001286_abnormal_eye_development1.07207556
63MP0006072_abnormal_retinal_apoptosis1.06373733
64MP0006036_abnormal_mitochondrial_physio1.03935951
65MP0009333_abnormal_splenocyte_physiolog1.02019542
66MP0004147_increased_porphyrin_level1.00267386
67MP0002111_abnormal_tail_morphology1.00050795
68MP0005670_abnormal_white_adipose0.98397473
69MP0003984_embryonic_growth_retardation0.98352743
70MP0002085_abnormal_embryonic_tissue0.97812300
71MP0002398_abnormal_bone_marrow0.97807729
72MP0003763_abnormal_thymus_physiology0.97144408
73MP0003119_abnormal_digestive_system0.96735601
74MP0002088_abnormal_embryonic_growth/wei0.95351132
75MP0003718_maternal_effect0.94498589
76MP0002233_abnormal_nose_morphology0.92657821
77MP0009053_abnormal_anal_canal0.92537323
78MP0002163_abnormal_gland_morphology0.92233730
79MP0008995_early_reproductive_senescence0.89338660
80MP0001119_abnormal_female_reproductive0.88944223
81MP0000689_abnormal_spleen_morphology0.87983243
82MP0000703_abnormal_thymus_morphology0.87969811
83MP0009379_abnormal_foot_pigmentation0.87239439
84MP0002084_abnormal_developmental_patter0.85781601
85MP0002092_abnormal_eye_morphology0.85129358
86MP0005174_abnormal_tail_pigmentation0.85123229
87MP0002722_abnormal_immune_system0.84733025
88MP0003315_abnormal_perineum_morphology0.83628005
89MP0009278_abnormal_bone_marrow0.82900015
90MP0001764_abnormal_homeostasis0.82042915
91MP0006292_abnormal_olfactory_placode0.81413894
92MP0000647_abnormal_sebaceous_gland0.78874699
93MP0003861_abnormal_nervous_system0.78821974
94MP0002429_abnormal_blood_cell0.77500165
95MP0005266_abnormal_metabolism0.76850465
96MP0005408_hypopigmentation0.76572474
97MP0002086_abnormal_extraembryonic_tissu0.76115275
98MP0006035_abnormal_mitochondrial_morpho0.75758762
99MP0010030_abnormal_orbit_morphology0.75697989
100MP0003942_abnormal_urinary_system0.75592098
101MP0002736_abnormal_nociception_after0.75453758
102MP0002751_abnormal_autonomic_nervous0.74933414
103MP0004197_abnormal_fetal_growth/weight/0.74235127
104MP0003938_abnormal_ear_development0.73320853
105MP0005501_abnormal_skin_physiology0.72771259
106MP0001835_abnormal_antigen_presentation0.72716195
107MP0003890_abnormal_embryonic-extraembry0.72092588
108MP0002249_abnormal_larynx_morphology0.71098394
109MP0000631_abnormal_neuroendocrine_gland0.68147912
110MP0005391_vision/eye_phenotype0.67279414
111MP0003755_abnormal_palate_morphology0.67113408
112MP0000858_altered_metastatic_potential0.66780556
113MP0001188_hyperpigmentation0.66053007
114MP0002405_respiratory_system_inflammati0.63683278
115MP0002877_abnormal_melanocyte_morpholog0.63421072
116MP0001727_abnormal_embryo_implantation0.63266702
117MP0003656_abnormal_erythrocyte_physiolo0.62654760
118MP0002095_abnormal_skin_pigmentation0.61672491
119MP0000716_abnormal_immune_system0.61239337
120MP0001919_abnormal_reproductive_system0.59395188
121MP0000015_abnormal_ear_pigmentation0.58992647
122MP0005084_abnormal_gallbladder_morpholo0.58186480
123MP0003567_abnormal_fetal_cardiomyocyte0.56514807
124MP0004233_abnormal_muscle_weight0.56473622
125MP0003699_abnormal_female_reproductive0.54653268
126MP0002282_abnormal_trachea_morphology0.51545612
127MP0000566_synostosis0.51074893
128MP0002420_abnormal_adaptive_immunity0.50552153
129MP0003121_genomic_imprinting0.50183816
130MP0001819_abnormal_immune_cell0.49725814
131MP0005671_abnormal_response_to0.49279231
132MP0005384_cellular_phenotype0.48783233
133MP0005025_abnormal_response_to0.48697463
134MP0002723_abnormal_immune_serum0.48465264
135MP0002102_abnormal_ear_morphology0.48161927
136MP0009785_altered_susceptibility_to0.47629074
137MP0003941_abnormal_skin_development0.45724561
138MP0002452_abnormal_antigen_presenting0.44915720
139MP0000685_abnormal_immune_system0.44825043
140MP0001800_abnormal_humoral_immune0.44750753

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.78907599
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.64291747
3Absent/shortened dynein arms (HP:0200106)7.64291747
4Abnormal respiratory epithelium morphology (HP:0012253)5.70800902
5Abnormal respiratory motile cilium morphology (HP:0005938)5.70800902
6Abnormal respiratory motile cilium physiology (HP:0012261)5.17790933
7Chronic bronchitis (HP:0004469)4.57239987
8Rhinitis (HP:0012384)4.38698445
9Nasal polyposis (HP:0100582)4.33674101
10Abnormal number of erythroid precursors (HP:0012131)4.15124044
11Abnormality of cells of the erythroid lineage (HP:0012130)4.14607053
12Acute necrotizing encephalopathy (HP:0006965)4.04954711
13Infertility (HP:0000789)3.98086491
14Abnormal mitochondria in muscle tissue (HP:0008316)3.91348871
15Abnormal ciliary motility (HP:0012262)3.88581272
16Reticulocytopenia (HP:0001896)3.80194572
17Acute encephalopathy (HP:0006846)3.74906762
18Abnormal spermatogenesis (HP:0008669)3.70716463
19Impulsivity (HP:0100710)3.52847703
20Mitochondrial inheritance (HP:0001427)3.51414304
21Abnormality of the nasal mucosa (HP:0000433)3.51260593
22Increased CSF lactate (HP:0002490)3.34937352
23Abnormality of the anterior horn cell (HP:0006802)3.27985506
24Degeneration of anterior horn cells (HP:0002398)3.27985506
25Hepatocellular necrosis (HP:0001404)3.26470788
26Bronchitis (HP:0012387)3.22828024
27Nephronophthisis (HP:0000090)3.13774429
28Birth length less than 3rd percentile (HP:0003561)3.08121285
29Progressive macrocephaly (HP:0004481)3.06024902
30Microvesicular hepatic steatosis (HP:0001414)2.98997043
31Increased hepatocellular lipid droplets (HP:0006565)2.98885074
32Bronchiectasis (HP:0002110)2.94810685
33Hepatic necrosis (HP:0002605)2.94770784
34Meckel diverticulum (HP:0002245)2.89704056
35Cerebral edema (HP:0002181)2.89213935
36Oral leukoplakia (HP:0002745)2.87854281
3711 pairs of ribs (HP:0000878)2.84431713
38Abnormality of the preputium (HP:0100587)2.84041559
39Abnormality of the ileum (HP:0001549)2.83402694
40Aplastic anemia (HP:0001915)2.78803251
41Selective tooth agenesis (HP:0001592)2.77461630
42Absent thumb (HP:0009777)2.69329299
43Hypoplasia of the capital femoral epiphysis (HP:0003090)2.69156757
44Lipid accumulation in hepatocytes (HP:0006561)2.68611410
45Abnormality of chromosome stability (HP:0003220)2.65706844
46Abnormality of the heme biosynthetic pathway (HP:0010472)2.64750403
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.63214813
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.61791300
49Abnormal number of incisors (HP:0011064)2.61657958
50Chromsome breakage (HP:0040012)2.58178591
51Breast hypoplasia (HP:0003187)2.51105428
52Azoospermia (HP:0000027)2.46190351
53Pallor (HP:0000980)2.45249832
54Lactic acidosis (HP:0003128)2.44833473
55Abnormality of the labia minora (HP:0012880)2.41847088
56Abnormality of glycolysis (HP:0004366)2.40487794
57Increased intramyocellular lipid droplets (HP:0012240)2.39935219
58Supernumerary spleens (HP:0009799)2.36879507
59Gonadotropin excess (HP:0000837)2.36523799
60Renal Fanconi syndrome (HP:0001994)2.36012495
61Duodenal stenosis (HP:0100867)2.33713726
62Small intestinal stenosis (HP:0012848)2.33713726
63Recurrent bronchitis (HP:0002837)2.33220048
64Macrocytic anemia (HP:0001972)2.32188250
65Absent radius (HP:0003974)2.31812734
66Increased serum pyruvate (HP:0003542)2.31111205
67Exercise intolerance (HP:0003546)2.29149176
68Thrombocytosis (HP:0001894)2.27270633
69Recurrent sinusitis (HP:0011108)2.25050280
70Myelodysplasia (HP:0002863)2.24808120
71Sloping forehead (HP:0000340)2.24534056
72Decreased activity of mitochondrial respiratory chain (HP:0008972)2.23024775
73Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.23024775
74Facial cleft (HP:0002006)2.22759991
75Bone marrow hypocellularity (HP:0005528)2.20330603
76Short thumb (HP:0009778)2.19400767
77Aplasia involving forearm bones (HP:0009822)2.18156171
78Absent forearm bone (HP:0003953)2.18156171
79Aplasia/Hypoplasia of the sacrum (HP:0008517)2.16112415
80Abnormality of the renal medulla (HP:0100957)2.15027132
81Ectopic kidney (HP:0000086)2.12535785
82Increased nuchal translucency (HP:0010880)2.12487963
83Male infertility (HP:0003251)2.12164390
84Recurrent otitis media (HP:0000403)2.09655135
85Agnosia (HP:0010524)2.08590593
86Respiratory failure (HP:0002878)2.04795551
87Clubbing of toes (HP:0100760)2.04678102
88Duplication of thumb phalanx (HP:0009942)1.98791036
89Progressive muscle weakness (HP:0003323)1.97964420
90Colon cancer (HP:0003003)1.97645256
91Microretrognathia (HP:0000308)1.97308496
92Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.96965666
93Absent epiphyses (HP:0010577)1.96965666
94Medulloblastoma (HP:0002885)1.96414647
95Patellar aplasia (HP:0006443)1.95465506
96Carpal bone hypoplasia (HP:0001498)1.94961154
97Type 2 muscle fiber atrophy (HP:0003554)1.93644263
98Respiratory difficulties (HP:0002880)1.93395080
99Abnormal lung lobation (HP:0002101)1.93232476
100Testicular atrophy (HP:0000029)1.93003943
101Multiple enchondromatosis (HP:0005701)1.92788750
102Premature ovarian failure (HP:0008209)1.92469650
103Abnormality of cochlea (HP:0000375)1.91899170
104Increased muscle lipid content (HP:0009058)1.91227885
105Rough bone trabeculation (HP:0100670)1.90018077
106Triphalangeal thumb (HP:0001199)1.89374772
107Hyperglycinemia (HP:0002154)1.88696098
108Muscle fiber atrophy (HP:0100295)1.88169916
109Duplicated collecting system (HP:0000081)1.87117481
110Aplasia/Hypoplasia of the patella (HP:0006498)1.86373818
111Squamous cell carcinoma (HP:0002860)1.84502812
112Abnormality of reticulocytes (HP:0004312)1.83841040
113Septo-optic dysplasia (HP:0100842)1.82988921
114Asplenia (HP:0001746)1.82612818
115Abnormality of the duodenum (HP:0002246)1.82109383
116Abnormality of DNA repair (HP:0003254)1.80940571
117Hypoplasia of the radius (HP:0002984)1.80212064
118Nephroblastoma (Wilms tumor) (HP:0002667)1.79890987
119Secondary amenorrhea (HP:0000869)1.79355882
120Abnormality of the carotid arteries (HP:0005344)1.78414659
121Molar tooth sign on MRI (HP:0002419)1.77523175
122Abnormality of midbrain morphology (HP:0002418)1.77523175
123Premature graying of hair (HP:0002216)1.76900280
124Postaxial foot polydactyly (HP:0001830)1.75465579
125Sclerocornea (HP:0000647)1.75282630
126Type I transferrin isoform profile (HP:0003642)1.74580605
127Hypoplastic pelvis (HP:0008839)1.74541596
128Abnormal protein glycosylation (HP:0012346)1.74007725
129Abnormal glycosylation (HP:0012345)1.74007725
130Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74007725
131Abnormal protein N-linked glycosylation (HP:0012347)1.74007725
132Broad distal phalanx of finger (HP:0009836)1.73323522
133Cortical dysplasia (HP:0002539)1.72821570
134Optic disc pallor (HP:0000543)1.72380508
135Pulmonary fibrosis (HP:0002206)1.72232569
136Tracheoesophageal fistula (HP:0002575)1.71550416
1373-Methylglutaconic aciduria (HP:0003535)1.71356990
138Hypoplasia of the pons (HP:0012110)1.71208186
139Neoplasm of the pancreas (HP:0002894)1.71016111
140* Leukodystrophy (HP:0002415)1.70026775
141Abnormality of the renal collecting system (HP:0004742)1.68635397
142Preaxial hand polydactyly (HP:0001177)1.67703762
143Ependymoma (HP:0002888)1.66213353
144* Pancytopenia (HP:0001876)1.66039244
145Horseshoe kidney (HP:0000085)1.65260127
146Embryonal renal neoplasm (HP:0011794)1.64600599
147Optic nerve coloboma (HP:0000588)1.63983588
148Cerebral hypomyelination (HP:0006808)1.62689169
149Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.61737416
150Abnormality of pyrimidine metabolism (HP:0004353)1.61235541
151Increased serum lactate (HP:0002151)1.60895962

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.17602653
2PDK34.50624117
3PDK44.50624117
4TESK14.46491523
5BUB13.84916040
6WEE13.39496254
7CDC73.30048231
8PDK22.87846283
9NEK22.78473165
10TLK12.49975417
11EIF2AK12.38368273
12STK162.19648963
13SRPK12.11923766
14TAF12.09266537
15TTK2.08541250
16PRKD32.03730822
17PASK2.02232584
18DYRK31.90069988
19NME21.79929201
20ICK1.77239915
21TSSK61.74471127
22TESK21.70870582
23VRK11.69112553
24SMG11.67956255
25PLK41.66808988
26PLK11.64257320
27ATR1.61986724
28NME11.55922331
29BRSK21.53038727
30CCNB11.49173394
31NEK11.32260774
32CDK71.27158830
33AURKB1.26626394
34ACVR1B1.25905994
35NUAK11.24939993
36CHEK21.24259163
37EIF2AK31.17894844
38TRIM281.14454404
39BRSK11.10407155
40MKNK11.06071825
41AURKA1.04795706
42EEF2K1.04634757
43ZAK1.02546595
44PAK40.99722757
45PLK30.96653640
46PIM20.95900896
47CHEK10.94386865
48RPS6KA40.94178066
49RPS6KB20.91289900
50PIM10.88371529
51CSNK1G30.86486603
52BCKDK0.83572460
53FLT30.81857116
54ATM0.78761896
55MST40.78554590
56MKNK20.78206996
57TGFBR10.77439680
58CDK40.75871820
59CLK10.75843453
60LIMK10.75195048
61DAPK10.71201433
62CSNK1G10.71192088
63STK40.70878869
64CSNK2A10.70406866
65MAP2K60.67674839
66STK100.67523623
67DYRK1B0.67225447
68MAP3K80.66999702
69PNCK0.66570496
70MAP2K70.64854420
71PTK2B0.64268564
72IRAK30.64099504
73IRAK40.63237247
74KDR0.61089052
75BRAF0.60957455
76PAK10.60930184
77MAPKAPK30.60687378
78CSNK2A20.59527327
79CSNK1A1L0.59510955
80YES10.57069495
81ARAF0.56494887
82ZAP700.56173298
83CDK20.55734290
84CSNK1G20.54732345
85ABL20.53846523
86MAP3K100.53703437
87BMPR1B0.53233950
88MAPKAPK50.52365959
89KIT0.51567267
90MAP4K10.51285353
91WNK30.51222062
92CDK11A0.48772255
93EIF2AK20.48646174
94STK30.47147096
95LRRK20.46696400
96CDK150.45876553
97CDK180.45669768
98RPS6KA50.45549376
99EPHA20.44985070
100PRKCI0.44690387
101CDK80.43606291
102CDK140.43134895
103CDK190.42220142
104MAP3K110.41158168
105BTK0.40854933
106CDK10.39363157
107ILK0.39224286
108AKT20.36593880
109RPS6KA60.36119968
110CSNK1E0.35668092
111CDK90.34741513
112INSRR0.34620640
113MAP2K30.34408345
114PRKDC0.32215463
115RPS6KC10.32124611
116RPS6KL10.32124611
117PINK10.31846325
118TYK20.31562563
119CSF1R0.30769213
120MAP4K20.30678522
121ERBB40.29296505
122WNK40.28726863
123CDK120.27798612
124DAPK30.27417723
125STK38L0.26169058
126MELK0.25946298
127SCYL20.25723836
128PLK20.25677304
129RPS6KB10.24730513
130PBK0.24717894
131STK380.24383173
132TEC0.23302445
133BLK0.23096641
134IRAK10.22614475
135RPS6KA10.21514953
136IKBKB0.20717058
137NEK90.20221070
138DYRK20.19546442
139ALK0.19292451

Predicted pathways (KEGG)

RankGene SetZ-score
1* DNA replication_Homo sapiens_hsa030304.82134800
2Mismatch repair_Homo sapiens_hsa034304.14865743
3Ribosome_Homo sapiens_hsa030103.68323263
4Proteasome_Homo sapiens_hsa030503.32509818
5Base excision repair_Homo sapiens_hsa034103.08842035
6Homologous recombination_Homo sapiens_hsa034403.07495947
7Spliceosome_Homo sapiens_hsa030403.00000284
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.98794633
9RNA transport_Homo sapiens_hsa030132.77419722
10Fanconi anemia pathway_Homo sapiens_hsa034602.75584645
11RNA polymerase_Homo sapiens_hsa030202.68375752
12Pyrimidine metabolism_Homo sapiens_hsa002402.67734492
13Nucleotide excision repair_Homo sapiens_hsa034202.64165006
14Basal transcription factors_Homo sapiens_hsa030222.31097444
15Cell cycle_Homo sapiens_hsa041102.26896668
16One carbon pool by folate_Homo sapiens_hsa006702.21428326
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16035749
18Non-homologous end-joining_Homo sapiens_hsa034501.99249352
19RNA degradation_Homo sapiens_hsa030181.72826342
20Purine metabolism_Homo sapiens_hsa002301.72102385
21mRNA surveillance pathway_Homo sapiens_hsa030151.65863222
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.58532952
23Vitamin B6 metabolism_Homo sapiens_hsa007501.51637940
24Selenocompound metabolism_Homo sapiens_hsa004501.50345960
25Systemic lupus erythematosus_Homo sapiens_hsa053221.37255960
26Pentose phosphate pathway_Homo sapiens_hsa000301.33548305
27Huntingtons disease_Homo sapiens_hsa050161.32404501
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29859890
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26389523
30Fatty acid elongation_Homo sapiens_hsa000621.23592805
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19487248
32p53 signaling pathway_Homo sapiens_hsa041151.19415426
33Antigen processing and presentation_Homo sapiens_hsa046121.15889319
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.10405900
35Pyruvate metabolism_Homo sapiens_hsa006201.06806098
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03863904
37Epstein-Barr virus infection_Homo sapiens_hsa051691.01940525
38Oocyte meiosis_Homo sapiens_hsa041140.99534750
39Biosynthesis of amino acids_Homo sapiens_hsa012300.98603757
40Glutathione metabolism_Homo sapiens_hsa004800.93440476
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92829965
42Parkinsons disease_Homo sapiens_hsa050120.92003485
43Fructose and mannose metabolism_Homo sapiens_hsa000510.90016468
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88161925
45Herpes simplex infection_Homo sapiens_hsa051680.86762475
46Carbon metabolism_Homo sapiens_hsa012000.85435160
47Sulfur relay system_Homo sapiens_hsa041220.83404164
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82948254
49Steroid biosynthesis_Homo sapiens_hsa001000.78916354
50Oxidative phosphorylation_Homo sapiens_hsa001900.78525950
51Linoleic acid metabolism_Homo sapiens_hsa005910.78159444
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77805235
53Legionellosis_Homo sapiens_hsa051340.77073053
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75164294
55Viral carcinogenesis_Homo sapiens_hsa052030.74378923
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73760895
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.71665190
58Protein export_Homo sapiens_hsa030600.70835604
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70151301
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69291060
61Folate biosynthesis_Homo sapiens_hsa007900.65952952
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.64492022
63HTLV-I infection_Homo sapiens_hsa051660.51558103
64Arachidonic acid metabolism_Homo sapiens_hsa005900.50603438
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50220985
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48381060
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46973951
68Alcoholism_Homo sapiens_hsa050340.46520063
69Metabolic pathways_Homo sapiens_hsa011000.46385251
70Fatty acid biosynthesis_Homo sapiens_hsa000610.44115287
71Arginine and proline metabolism_Homo sapiens_hsa003300.43839445
72Measles_Homo sapiens_hsa051620.43041857
73Propanoate metabolism_Homo sapiens_hsa006400.41595474
74N-Glycan biosynthesis_Homo sapiens_hsa005100.41535432
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41400820
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38548105
77Galactose metabolism_Homo sapiens_hsa000520.38292772
78Primary immunodeficiency_Homo sapiens_hsa053400.37842222
79Fatty acid metabolism_Homo sapiens_hsa012120.34732731
80Alzheimers disease_Homo sapiens_hsa050100.33745378
81Glucagon signaling pathway_Homo sapiens_hsa049220.33428564
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32688312
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32134506
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32009088
85Peroxisome_Homo sapiens_hsa041460.31105950
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30991673
87Hippo signaling pathway_Homo sapiens_hsa043900.27589310
88Lysine degradation_Homo sapiens_hsa003100.26073740
89Influenza A_Homo sapiens_hsa051640.25876490
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24488309
91Butanoate metabolism_Homo sapiens_hsa006500.24473593
92Cardiac muscle contraction_Homo sapiens_hsa042600.23595668
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23297731
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.23224427
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23137632
96Basal cell carcinoma_Homo sapiens_hsa052170.20032140
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20013381
98Glycerolipid metabolism_Homo sapiens_hsa005610.19000126
99Apoptosis_Homo sapiens_hsa042100.18864217
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18327485
101HIF-1 signaling pathway_Homo sapiens_hsa040660.18174087
102Sulfur metabolism_Homo sapiens_hsa009200.18080876
103Hedgehog signaling pathway_Homo sapiens_hsa043400.17784258
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17751130
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.17485615
106Thyroid cancer_Homo sapiens_hsa052160.17429136
107Hematopoietic cell lineage_Homo sapiens_hsa046400.16924798
108Wnt signaling pathway_Homo sapiens_hsa043100.16910243
109Tyrosine metabolism_Homo sapiens_hsa003500.16792835
110Fat digestion and absorption_Homo sapiens_hsa049750.16554214
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15802768
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.15621708
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.13713059
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.13219314
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.12761751
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.11923849
117Small cell lung cancer_Homo sapiens_hsa052220.11744839
118Bladder cancer_Homo sapiens_hsa052190.11565303
119beta-Alanine metabolism_Homo sapiens_hsa004100.11115590
120Shigellosis_Homo sapiens_hsa051310.10579331
121Hepatitis B_Homo sapiens_hsa051610.09838261
122Tryptophan metabolism_Homo sapiens_hsa003800.09457416
123Renin-angiotensin system_Homo sapiens_hsa046140.09386434
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.06462735
125Vitamin digestion and absorption_Homo sapiens_hsa049770.06443213
126Phenylalanine metabolism_Homo sapiens_hsa003600.05925862
127Fatty acid degradation_Homo sapiens_hsa000710.05700448
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.04672040
129Phototransduction_Homo sapiens_hsa047440.04457492
130TGF-beta signaling pathway_Homo sapiens_hsa043500.04075323

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