RNASEH2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.37093990
2telomere maintenance via semi-conservative replication (GO:0032201)5.28169797
3DNA strand elongation (GO:0022616)5.13011182
4sulfation (GO:0051923)5.02062478
5DNA replication initiation (GO:0006270)4.81881466
6telomere maintenance via recombination (GO:0000722)4.72420523
7ribosomal small subunit assembly (GO:0000028)4.66479728
8DNA replication checkpoint (GO:0000076)4.55791228
9mitotic recombination (GO:0006312)4.43261222
10DNA unwinding involved in DNA replication (GO:0006268)4.41509075
11DNA deamination (GO:0045006)4.39339086
12response to UV-C (GO:0010225)4.36285886
13CENP-A containing nucleosome assembly (GO:0034080)4.33364153
14chromatin remodeling at centromere (GO:0031055)4.22678250
15telomere maintenance via telomere lengthening (GO:0010833)4.17068940
16maturation of SSU-rRNA (GO:0030490)4.16493837
17behavioral response to nicotine (GO:0035095)4.14847921
18regulation of DNA endoreduplication (GO:0032875)4.14455424
19nucleotide-excision repair, DNA gap filling (GO:0006297)4.05030907
20kinetochore organization (GO:0051383)4.02965450
21viral transcription (GO:0019083)3.89064341
22translational termination (GO:0006415)3.84803165
23cellular response to ATP (GO:0071318)3.82386272
24deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.81748781
25ribosomal large subunit biogenesis (GO:0042273)3.80485176
26pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.79203093
27ribosomal small subunit biogenesis (GO:0042274)3.78859586
28DNA replication-independent nucleosome organization (GO:0034724)3.78032164
29DNA replication-independent nucleosome assembly (GO:0006336)3.78032164
30kinetochore assembly (GO:0051382)3.76367371
31formation of translation preinitiation complex (GO:0001731)3.74804161
32water-soluble vitamin biosynthetic process (GO:0042364)3.74041025
33regulation of glomerulus development (GO:0090192)3.66466127
34regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.64734807
35nucleobase biosynthetic process (GO:0046112)3.64437291
36proteasome assembly (GO:0043248)3.62668600
37cell proliferation in forebrain (GO:0021846)3.60705453
38protein localization to kinetochore (GO:0034501)3.56238887
39mitotic metaphase plate congression (GO:0007080)3.45272421
40purine nucleobase biosynthetic process (GO:0009113)3.43841739
41ribonucleoprotein complex biogenesis (GO:0022613)3.42779417
42meiotic chromosome segregation (GO:0045132)3.40698502
43regulation of cell proliferation involved in kidney development (GO:1901722)3.38509830
44SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.38152054
45translational elongation (GO:0006414)3.38069059
46mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37865509
47mitochondrial respiratory chain complex I assembly (GO:0032981)3.37865509
48NADH dehydrogenase complex assembly (GO:0010257)3.37865509
49histone exchange (GO:0043486)3.35295210
50regulation of double-strand break repair via homologous recombination (GO:0010569)3.35270855
51DNA replication-dependent nucleosome organization (GO:0034723)3.33677363
52DNA replication-dependent nucleosome assembly (GO:0006335)3.33677363
53cotranslational protein targeting to membrane (GO:0006613)3.32015144
54translational initiation (GO:0006413)3.31519871
55attachment of spindle microtubules to kinetochore (GO:0008608)3.29062033
56rRNA processing (GO:0006364)3.28250905
57protein targeting to ER (GO:0045047)3.28174527
58mismatch repair (GO:0006298)3.26671186
59mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.23647966
60protein complex biogenesis (GO:0070271)3.23002255
61regulation of nuclear cell cycle DNA replication (GO:0033262)3.22107720
62nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.21150642
63transcription-coupled nucleotide-excision repair (GO:0006283)3.20978235
64telomere organization (GO:0032200)3.20629346
65telomere maintenance (GO:0000723)3.20222126
66ribosome assembly (GO:0042255)3.19994855
67protein localization to chromosome, centromeric region (GO:0071459)3.19092793
68IMP biosynthetic process (GO:0006188)3.18486243
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.18288316
70pseudouridine synthesis (GO:0001522)3.17750527
71indole-containing compound catabolic process (GO:0042436)3.16240913
72indolalkylamine catabolic process (GO:0046218)3.16240913
73tryptophan catabolic process (GO:0006569)3.16240913
74rRNA metabolic process (GO:0016072)3.15933978
75ribosome biogenesis (GO:0042254)3.15613296
76spliceosomal snRNP assembly (GO:0000387)3.14893427
77rRNA modification (GO:0000154)3.13463459
78establishment of integrated proviral latency (GO:0075713)3.12291035
79metaphase plate congression (GO:0051310)3.11846327
80deoxyribonucleotide biosynthetic process (GO:0009263)3.11728584
81establishment of protein localization to endoplasmic reticulum (GO:0072599)3.10411024
82establishment of protein localization to mitochondrial membrane (GO:0090151)3.10403086
83pyrimidine nucleotide catabolic process (GO:0006244)3.10060693
84protein localization to endoplasmic reticulum (GO:0070972)3.09942142
85exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07930845
86maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.07045186
87mitochondrial respiratory chain complex assembly (GO:0033108)3.06681354
88anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05348396
89somatic diversification of immune receptors via somatic mutation (GO:0002566)3.04274504
90somatic hypermutation of immunoglobulin genes (GO:0016446)3.04274504
91ATP synthesis coupled proton transport (GO:0015986)3.03944825
92energy coupled proton transport, down electrochemical gradient (GO:0015985)3.03944825
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.03426439
94negative regulation of B cell apoptotic process (GO:0002903)3.03346037
95cellular protein complex disassembly (GO:0043624)3.02442103
96mitotic nuclear envelope disassembly (GO:0007077)3.01990659
97G1/S transition of mitotic cell cycle (GO:0000082)3.00166687
98cell cycle G1/S phase transition (GO:0044843)3.00166687
99deoxyribonucleotide catabolic process (GO:0009264)2.99885239
100double-strand break repair via homologous recombination (GO:0000724)2.99482833
101recombinational repair (GO:0000725)2.99268112
102DNA catabolic process, exonucleolytic (GO:0000738)2.98048536
103polyketide metabolic process (GO:0030638)2.96504191
104doxorubicin metabolic process (GO:0044598)2.96504191
105daunorubicin metabolic process (GO:0044597)2.96504191
106viral life cycle (GO:0019058)2.96414973
107nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.95590596
108positive regulation of fatty acid beta-oxidation (GO:0032000)2.94973027
109positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.94870308
110translation (GO:0006412)2.94033194
111mitotic sister chromatid segregation (GO:0000070)2.93743097
112DNA double-strand break processing (GO:0000729)2.92167036
113deoxyribose phosphate catabolic process (GO:0046386)2.91251455
114negative regulation of transcription regulatory region DNA binding (GO:2000678)2.90809785
115positive regulation of B cell differentiation (GO:0045579)2.90418642
116negative regulation of ligase activity (GO:0051352)2.90173044
117negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.90173044
118viral mRNA export from host cell nucleus (GO:0046784)2.89353624
119IMP metabolic process (GO:0046040)2.88726183
120regulation of germinal center formation (GO:0002634)2.88241206
121protein K6-linked ubiquitination (GO:0085020)2.87302902
122tryptophan metabolic process (GO:0006568)2.87029053
123establishment of chromosome localization (GO:0051303)2.86995894
124negative regulation by host of viral transcription (GO:0043922)2.86198291
125cellular response to exogenous dsRNA (GO:0071360)2.86189634
126DNA ligation (GO:0006266)2.85844921
127DNA replication (GO:0006260)2.83778551
128kynurenine metabolic process (GO:0070189)2.83611743
129purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.80891058
1303-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.80891058
131base-excision repair, AP site formation (GO:0006285)2.80871382
132DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.80463810
133pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.80430432
134intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.79862563
135signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.79862563
136signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.79605990
137signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.79605990
138signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.79605990
139spliceosomal complex assembly (GO:0000245)2.78482156
140alternative mRNA splicing, via spliceosome (GO:0000380)2.77619148
141transcription elongation from RNA polymerase III promoter (GO:0006385)2.76937110
142termination of RNA polymerase III transcription (GO:0006386)2.76937110
143indolalkylamine metabolic process (GO:0006586)2.76134897
144regulation of mitochondrial translation (GO:0070129)2.75649625
145epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.71723709
146replication fork processing (GO:0031297)2.71517999
147GPI anchor metabolic process (GO:0006505)2.68715855
148positive regulation of granulocyte differentiation (GO:0030854)2.63297107
149mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.61054093
150protein polyglutamylation (GO:0018095)2.60847366
151purine deoxyribonucleotide catabolic process (GO:0009155)2.59762428
152positive regulation of cAMP-mediated signaling (GO:0043950)2.55716482
153otic vesicle formation (GO:0030916)2.54455168
154chaperone-mediated protein transport (GO:0072321)2.53096729
155cellular anion homeostasis (GO:0030002)2.52941685
156centriole replication (GO:0007099)2.51620522
157negative regulation of gene silencing (GO:0060969)2.51137494
158positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.50389142
159replicative senescence (GO:0090399)2.49771499
160regulation of gene silencing by RNA (GO:0060966)2.49205046
161regulation of posttranscriptional gene silencing (GO:0060147)2.49205046
162regulation of gene silencing by miRNA (GO:0060964)2.49205046
163regulation of phospholipid biosynthetic process (GO:0071071)2.44984687
164respiratory electron transport chain (GO:0022904)2.44236463
165positive regulation of mast cell activation (GO:0033005)2.43210351
166rRNA catabolic process (GO:0016075)2.42575266
167cytochrome complex assembly (GO:0017004)2.41786876
168negative regulation of cell cycle arrest (GO:0071157)2.41541109
169electron transport chain (GO:0022900)2.41438370
170negative regulation of response to food (GO:0032096)2.40410470
171negative regulation of appetite (GO:0032099)2.40410470

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.75354422
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.35562175
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.14881094
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.06127726
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.59781264
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.54428855
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.42873175
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.20923598
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.17486110
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.10236227
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.98805545
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.81636070
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.79946474
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.78575290
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.78292611
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.76453475
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.75768711
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.73910720
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.61033065
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.47182435
21VDR_23849224_ChIP-Seq_CD4+_Human2.42910542
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39442872
23XRN2_22483619_ChIP-Seq_HELA_Human2.17066402
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15599371
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15051826
26FOXP3_21729870_ChIP-Seq_TREG_Human2.14179518
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.10752074
28IGF1R_20145208_ChIP-Seq_DFB_Human2.06342189
29DCP1A_22483619_ChIP-Seq_HELA_Human2.02730939
30EWS_26573619_Chip-Seq_HEK293_Human2.02488607
31AR_21909140_ChIP-Seq_LNCAP_Human2.01452067
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.01268678
33E2F1_21310950_ChIP-Seq_MCF-7_Human2.01100233
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.00366219
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98146669
36TTF2_22483619_ChIP-Seq_HELA_Human1.89100240
37ZNF274_21170338_ChIP-Seq_K562_Hela1.89060554
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86970656
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85687364
40ELK1_19687146_ChIP-ChIP_HELA_Human1.84001645
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83569998
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81905402
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79916385
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.76272635
45GABP_19822575_ChIP-Seq_HepG2_Human1.75227545
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.73582436
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.70958608
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69344755
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69111426
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65664409
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64718929
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.64381948
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61139097
54FUS_26573619_Chip-Seq_HEK293_Human1.60067279
55* MYB_26560356_Chip-Seq_TH2_Human1.58924199
56* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58796415
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56463740
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55409676
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53886712
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50676327
61EZH2_22144423_ChIP-Seq_EOC_Human1.50604812
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49605372
63* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48608667
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48042236
65CIITA_25753668_ChIP-Seq_RAJI_Human1.46189534
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40089484
67KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39333118
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37171021
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32573332
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26180721
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.24811725
72GATA3_27048872_Chip-Seq_THYMUS_Human1.23939431
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.23025632
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21830615
75* RUNX_20019798_ChIP-Seq_JUKART_Human1.21749226
76KDM5A_27292631_Chip-Seq_BREAST_Human1.20422510
77IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19156031
78SPI1_23547873_ChIP-Seq_NB4_Human1.16821811
79* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16683950
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16284779
81EGR1_19374776_ChIP-ChIP_THP-1_Human1.16158591
82MYC_18940864_ChIP-ChIP_HL60_Human1.14765760
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14019582
84MYB_26560356_Chip-Seq_TH1_Human1.12945710
85* GATA3_26560356_Chip-Seq_TH2_Human1.11747957
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11229375
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11051247
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08734478
89SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07134028
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06807142
91* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06713319
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06194644
93AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05919360
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05324971
95* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04992999
96ER_23166858_ChIP-Seq_MCF-7_Human1.02954155
97TFEB_21752829_ChIP-Seq_HELA_Human1.00388124
98IRF1_19129219_ChIP-ChIP_H3396_Human0.98246294
99VDR_22108803_ChIP-Seq_LS180_Human0.97548704
100CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97536073
101EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97404913
102VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96329382
103CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96046291
104TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95548405
105TP53_22573176_ChIP-Seq_HFKS_Human0.90684476
106MYC_22102868_ChIP-Seq_BL_Human0.90245321
107SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90152808
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90108111
109CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90037293
110FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89681829
111FOXA1_25329375_ChIP-Seq_VCAP_Human0.89681829
112* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89263722
113RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89203471
114VDR_24763502_ChIP-Seq_THP-1_Human0.87986804
115VDR_21846776_ChIP-Seq_THP-1_Human0.85577305
116BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83909604
117NANOG_16153702_ChIP-ChIP_HESCs_Human0.83862512
118BP1_19119308_ChIP-ChIP_Hs578T_Human0.83683064
119BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83441002
120CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83322246
121IRF8_21731497_ChIP-ChIP_J774_Mouse0.82810890
122ELK1_22589737_ChIP-Seq_MCF10A_Human0.81646054
123STAT4_19710469_ChIP-ChIP_TH1__Mouse0.80993653
124* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.78546615
125CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.76981181
126MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.76461945
127SCL_19346495_ChIP-Seq_HPC-7_Human0.75858150
128FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70526018
129NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.70405114
130STAT3_1855785_ChIP-Seq_MESCs_Mouse0.70337817
131IRF8_22096565_ChIP-ChIP_GC-B_Human0.69827311
132POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.68173084
133SOX17_20123909_ChIP-Seq_XEN_Mouse0.66330162
134KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.64503538
135KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.64503538
136KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.64503538
137CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.63035529

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.10284051
2MP0010094_abnormal_chromosome_stability4.90886823
3MP0008057_abnormal_DNA_replication4.52866969
4MP0003111_abnormal_nucleus_morphology4.21374143
5MP0004957_abnormal_blastocyst_morpholog3.84501059
6MP0008058_abnormal_DNA_repair3.79645374
7MP0003077_abnormal_cell_cycle3.74414833
8MP0002396_abnormal_hematopoietic_system3.16882291
9MP0004134_abnormal_chest_morphology2.70584878
10MP0008007_abnormal_cellular_replicative2.68175043
11MP0008932_abnormal_embryonic_tissue2.48707418
12MP0002160_abnormal_reproductive_system2.42173975
13MP0003646_muscle_fatigue2.25057685
14MP0006292_abnormal_olfactory_placode2.10037025
15MP0005646_abnormal_pituitary_gland2.09875667
16MP0004145_abnormal_muscle_electrophysio2.00982414
17MP0000490_abnormal_crypts_of2.00743337
18MP0008877_abnormal_DNA_methylation1.99044445
19MP0003786_premature_aging1.98055687
20MP0008872_abnormal_physiological_respon1.92587750
21MP0001485_abnormal_pinna_reflex1.77367803
22MP0004147_increased_porphyrin_level1.74688484
23MP0002837_dystrophic_cardiac_calcinosis1.71282722
24MP0000350_abnormal_cell_proliferation1.70137314
25MP0003763_abnormal_thymus_physiology1.69324298
26MP0003195_calcinosis1.63991042
27MP0009333_abnormal_splenocyte_physiolog1.62073368
28MP0002132_abnormal_respiratory_system1.55340686
29MP0001730_embryonic_growth_arrest1.53115101
30MP0009379_abnormal_foot_pigmentation1.51204733
31MP0001835_abnormal_antigen_presentation1.49687822
32MP0000631_abnormal_neuroendocrine_gland1.49360989
33MP0004142_abnormal_muscle_tone1.46832407
34MP0003718_maternal_effect1.43384602
35MP0000313_abnormal_cell_death1.42881088
36MP0002398_abnormal_bone_marrow1.41495485
37MP0002019_abnormal_tumor_incidence1.37280203
38MP0005379_endocrine/exocrine_gland_phen1.36396320
39MP0005671_abnormal_response_to1.33794861
40MP0000678_abnormal_parathyroid_gland1.33183921
41MP0002876_abnormal_thyroid_physiology1.32377015
42MP0005075_abnormal_melanosome_morpholog1.31704904
43MP0000703_abnormal_thymus_morphology1.29857226
44MP0002138_abnormal_hepatobiliary_system1.29523896
45MP0008995_early_reproductive_senescence1.28625188
46MP0001545_abnormal_hematopoietic_system1.28357939
47MP0005397_hematopoietic_system_phenotyp1.28357939
48MP0002095_abnormal_skin_pigmentation1.27968007
49MP0005084_abnormal_gallbladder_morpholo1.27731433
50MP0000049_abnormal_middle_ear1.26047796
51MP0003186_abnormal_redox_activity1.25181598
52MP0004808_abnormal_hematopoietic_stem1.25017473
53MP0003638_abnormal_response/metabolism_1.24972305
54MP0006072_abnormal_retinal_apoptosis1.23560451
55MP0002722_abnormal_immune_system1.23407540
56MP0008260_abnormal_autophagy1.22538209
57MP0003136_yellow_coat_color1.20750336
58MP0002210_abnormal_sex_determination1.19425466
59MP0000685_abnormal_immune_system1.19142376
60MP0004130_abnormal_muscle_cell1.18835353
61MP0010307_abnormal_tumor_latency1.16709620
62MP0003724_increased_susceptibility_to1.16700137
63MP0002429_abnormal_blood_cell1.15650338
64MP0000689_abnormal_spleen_morphology1.15076320
65MP0003567_abnormal_fetal_cardiomyocyte1.13766643
66MP0005174_abnormal_tail_pigmentation1.12932137
67MP0006036_abnormal_mitochondrial_physio1.12805755
68MP0001697_abnormal_embryo_size1.12425704
69MP0009250_abnormal_appendicular_skeleto1.12168780
70MP0000716_abnormal_immune_system1.09105026
71MP0003123_paternal_imprinting1.08800282
72MP0003656_abnormal_erythrocyte_physiolo1.07676676
73MP0005380_embryogenesis_phenotype1.07471138
74MP0001672_abnormal_embryogenesis/_devel1.07471138
75MP0002080_prenatal_lethality1.07102135
76MP0010352_gastrointestinal_tract_polyps1.06708815
77MP0001293_anophthalmia1.06427492
78MP0001800_abnormal_humoral_immune1.05433131
79MP0003787_abnormal_imprinting1.05004268
80MP0001986_abnormal_taste_sensitivity1.02637468
81MP0002277_abnormal_respiratory_mucosa1.02523213
82MP0002420_abnormal_adaptive_immunity1.01702605
83MP0001819_abnormal_immune_cell1.00354480
84MP0001145_abnormal_male_reproductive0.99993421
85MP0005551_abnormal_eye_electrophysiolog0.98627614
86MP0009697_abnormal_copulation0.98220698
87MP0002163_abnormal_gland_morphology0.97635656
88MP0002085_abnormal_embryonic_tissue0.96554194
89MP0009765_abnormal_xenobiotic_induced0.96084380
90MP0002452_abnormal_antigen_presenting0.95430953
91MP0001853_heart_inflammation0.95073903
92MP0009785_altered_susceptibility_to0.94250278
93MP0002148_abnormal_hypersensitivity_rea0.93292174
94MP0005025_abnormal_response_to0.91940945
95MP0002723_abnormal_immune_serum0.90742050
96MP0003984_embryonic_growth_retardation0.89822565
97MP0002419_abnormal_innate_immunity0.89808893
98MP0009764_decreased_sensitivity_to0.87743237
99MP0002938_white_spotting0.86684820
100MP0001929_abnormal_gametogenesis0.86349234
101MP0001873_stomach_inflammation0.85650530
102MP0000566_synostosis0.85592003
103MP0001919_abnormal_reproductive_system0.85382015
104MP0000015_abnormal_ear_pigmentation0.85379801
105MP0002102_abnormal_ear_morphology0.84921239
106MP0002735_abnormal_chemical_nociception0.84795777
107MP0002088_abnormal_embryonic_growth/wei0.84762468
108MP0000653_abnormal_sex_gland0.83570378
109MP0003890_abnormal_embryonic-extraembry0.83028361
110MP0006035_abnormal_mitochondrial_morpho0.82839384
111MP0003806_abnormal_nucleotide_metabolis0.82229468
112MP0005000_abnormal_immune_tolerance0.81749773
113MP0003315_abnormal_perineum_morphology0.81120918
114MP0003183_abnormal_peptide_metabolism0.80822900
115MP0004215_abnormal_myocardial_fiber0.80671440
116MP0002405_respiratory_system_inflammati0.78037179
117MP0004742_abnormal_vestibular_system0.78012841
118MP0000681_abnormal_thyroid_gland0.77984315
119MP0005266_abnormal_metabolism0.77906298
120MP0002086_abnormal_extraembryonic_tissu0.76148224
121MP0004185_abnormal_adipocyte_glucose0.75595884
122MP0009046_muscle_twitch0.74729284
123MP0000858_altered_metastatic_potential0.73844751
124MP0002075_abnormal_coat/hair_pigmentati0.73663799
125MP0001119_abnormal_female_reproductive0.72173295
126MP0001529_abnormal_vocalization0.71570579
127MP0002006_tumorigenesis0.70535145
128MP0002084_abnormal_developmental_patter0.70093967
129MP0004133_heterotaxia0.69557332
130MP0003121_genomic_imprinting0.69368728
131MP0004197_abnormal_fetal_growth/weight/0.68981032
132MP0000465_gastrointestinal_hemorrhage0.67457476
133MP0000372_irregular_coat_pigmentation0.67342577
134MP0003878_abnormal_ear_physiology0.66509025
135MP0005377_hearing/vestibular/ear_phenot0.66509025
136MP0002009_preneoplasia0.65317303
137MP0001790_abnormal_immune_system0.65148197
138MP0005387_immune_system_phenotype0.65148197
139MP0002166_altered_tumor_susceptibility0.64074003
140MP0005389_reproductive_system_phenotype0.63923094

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.89239308
2Reticulocytopenia (HP:0001896)4.88089877
3Chromsome breakage (HP:0040012)4.63592309
4Abnormality of cells of the erythroid lineage (HP:0012130)4.46633838
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.42952596
6Abnormal number of erythroid precursors (HP:0012131)4.41364722
7Abnormality of B cell number (HP:0010975)4.10901871
8B lymphocytopenia (HP:0010976)4.06123407
9Pendular nystagmus (HP:0012043)3.84709456
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.77380431
11Abnormality of the preputium (HP:0100587)3.42019581
12Genetic anticipation (HP:0003743)3.40693329
13Methylmalonic acidemia (HP:0002912)3.38251638
14Abnormality of chromosome stability (HP:0003220)3.37750305
15Duplicated collecting system (HP:0000081)3.37034947
16Abolished electroretinogram (ERG) (HP:0000550)3.34706121
17Meckel diverticulum (HP:0002245)3.29917212
18Panhypogammaglobulinemia (HP:0003139)3.22311428
19Severe combined immunodeficiency (HP:0004430)3.22005426
20Breast hypoplasia (HP:0003187)3.19352712
21Aplastic anemia (HP:0001915)3.19335302
22Abnormality of the ileum (HP:0001549)3.14414013
23Oral leukoplakia (HP:0002745)3.13782154
24Aplasia/Hypoplasia of the uvula (HP:0010293)3.13336554
25Abnormality of the renal collecting system (HP:0004742)3.13266030
26Pallor (HP:0000980)3.07161561
27Pancreatic cysts (HP:0001737)3.06048638
28Methylmalonic aciduria (HP:0012120)3.04969649
29Macrocytic anemia (HP:0001972)2.93240930
30Colon cancer (HP:0003003)2.92158819
31Pancreatic fibrosis (HP:0100732)2.90067736
32Severe visual impairment (HP:0001141)2.87757229
33Thyroiditis (HP:0100646)2.79296814
34Patellar aplasia (HP:0006443)2.79094315
35Type I transferrin isoform profile (HP:0003642)2.77731730
36True hermaphroditism (HP:0010459)2.73038224
37Abnormality of the heme biosynthetic pathway (HP:0010472)2.72237356
38Bone marrow hypocellularity (HP:0005528)2.70962532
39Renal cortical cysts (HP:0000803)2.70302791
40Abnormal rod and cone electroretinograms (HP:0008323)2.67983596
41Absent thumb (HP:0009777)2.67694002
42Aplasia/Hypoplasia of the sacrum (HP:0008517)2.64625994
43Ectopic kidney (HP:0000086)2.63305573
44Rough bone trabeculation (HP:0100670)2.62173281
45Small intestinal stenosis (HP:0012848)2.61953076
46Duodenal stenosis (HP:0100867)2.61953076
47Abnormality of homocysteine metabolism (HP:0010919)2.61776304
48Homocystinuria (HP:0002156)2.61776304
49Premature graying of hair (HP:0002216)2.61596506
50Aplasia/Hypoplasia of the patella (HP:0006498)2.60860867
51Agnosia (HP:0010524)2.60436060
52Decreased central vision (HP:0007663)2.59291961
53Myelodysplasia (HP:0002863)2.58121303
54Combined immunodeficiency (HP:0005387)2.57608612
55Conjunctival hamartoma (HP:0100780)2.49899109
56Visual hallucinations (HP:0002367)2.49147139
57Agitation (HP:0000713)2.49127676
5811 pairs of ribs (HP:0000878)2.47805529
59Pancytopenia (HP:0001876)2.43884436
60Medulloblastoma (HP:0002885)2.42853244
61Confusion (HP:0001289)2.40821916
62Triphalangeal thumb (HP:0001199)2.36023638
63Selective tooth agenesis (HP:0001592)2.34359730
64Absent radius (HP:0003974)2.34210194
65Cerebral hypomyelination (HP:0006808)2.32846461
66Asplenia (HP:0001746)2.32153225
67Clubbing of toes (HP:0100760)2.29400425
68Increased hepatocellular lipid droplets (HP:0006565)2.29091852
69Sloping forehead (HP:0000340)2.27926457
70Lymphoma (HP:0002665)2.27145241
71Hypoplasia of the capital femoral epiphysis (HP:0003090)2.26011950
72Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.25287413
73Acute necrotizing encephalopathy (HP:0006965)2.23854160
74Congenital, generalized hypertrichosis (HP:0004540)2.22239118
75Tinnitus (HP:0000360)2.21684507
76Carpal bone hypoplasia (HP:0001498)2.20875454
77Abnormality of DNA repair (HP:0003254)2.20739905
78Aplasia/Hypoplasia of the spleen (HP:0010451)2.20439562
79Hypoplasia of the thymus (HP:0000778)2.19282793
80Abnormal lung lobation (HP:0002101)2.18945990
81Impulsivity (HP:0100710)2.18491570
82Aplasia involving forearm bones (HP:0009822)2.17915896
83Absent forearm bone (HP:0003953)2.17915896
84Progressive cerebellar ataxia (HP:0002073)2.17382708
85Reduced antithrombin III activity (HP:0001976)2.16746898
86Furrowed tongue (HP:0000221)2.16153411
87Abnormal trabecular bone morphology (HP:0100671)2.15689163
88Microretrognathia (HP:0000308)2.12338550
89Thrombocytosis (HP:0001894)2.12325492
90Abnormality of the anterior horn cell (HP:0006802)2.11339758
91Degeneration of anterior horn cells (HP:0002398)2.11339758
92Horseshoe kidney (HP:0000085)2.10852915
93Microvesicular hepatic steatosis (HP:0001414)2.10705820
94Congenital stationary night blindness (HP:0007642)2.10031234
95IgM deficiency (HP:0002850)2.09595717
96Abnormal mitochondria in muscle tissue (HP:0008316)2.09414564
97Increased corneal curvature (HP:0100692)2.08406415
98Keratoconus (HP:0000563)2.08406415
993-Methylglutaconic aciduria (HP:0003535)2.08340613
100Tracheoesophageal fistula (HP:0002575)2.08202603
101Abnormality of the duodenum (HP:0002246)2.07738693
102Eosinophilia (HP:0001880)2.07577134
103Decreased activity of mitochondrial respiratory chain (HP:0008972)2.07230295
104Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.07230295
105Attenuation of retinal blood vessels (HP:0007843)2.07177324
106Exertional dyspnea (HP:0002875)2.05475936
107Abnormality of the prostate (HP:0008775)2.04843020
108Hepatic necrosis (HP:0002605)2.03779550
109Cellular immunodeficiency (HP:0005374)2.01639160
110Increased serum lactate (HP:0002151)2.01507167
111Sparse eyelashes (HP:0000653)2.01003378
112Abnormality of the phalanges of the 5th finger (HP:0004213)2.00162399
113Abnormality of the phalanges of the 2nd finger (HP:0009541)1.99887130
114Granulocytopenia (HP:0001913)1.99029187
115Abnormality of the carotid arteries (HP:0005344)1.97814391
116Progressive macrocephaly (HP:0004481)1.96989142
117Small hand (HP:0200055)1.96716817
118Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96272222
119Dicarboxylic aciduria (HP:0003215)1.96272222
120Abnormality of methionine metabolism (HP:0010901)1.95935098
121Abnormality of the vitamin B12 metabolism (HP:0004341)1.93269740
122Abnormality of aspartate family amino acid metabolism (HP:0010899)1.93024809
123Abnormality of the renal cortex (HP:0011035)1.92957395
124Agammaglobulinemia (HP:0004432)1.92814090
125Amaurosis fugax (HP:0100576)1.91701744
126Autoimmune hemolytic anemia (HP:0001890)1.90210903
127Hepatocellular necrosis (HP:0001404)1.88337284
128Septo-optic dysplasia (HP:0100842)1.87181401
129Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86259416
130Supernumerary spleens (HP:0009799)1.86048080
131Abnormal protein glycosylation (HP:0012346)1.85272118
132Abnormal glycosylation (HP:0012345)1.85272118
133Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85272118
134Abnormal protein N-linked glycosylation (HP:0012347)1.85272118
135Lipid accumulation in hepatocytes (HP:0006561)1.83860429
136Hypoplastic pelvis (HP:0008839)1.83788990
137Recurrent fungal infections (HP:0002841)1.83621478
138Acute encephalopathy (HP:0006846)1.83604352
139Nephronophthisis (HP:0000090)1.82739603
140Abnormal number of incisors (HP:0011064)1.82622042
141Petechiae (HP:0000967)1.82573102
142Prostate neoplasm (HP:0100787)1.81809929
143Abnormality of cochlea (HP:0000375)1.81154510
144Neoplasm of the pancreas (HP:0002894)1.80960898
145Increased CSF lactate (HP:0002490)1.80620844
146Abnormality of reticulocytes (HP:0004312)1.80316188
147Abnormality of eosinophils (HP:0001879)1.80137605
148Optic nerve coloboma (HP:0000588)1.79471396
149Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.79148750
150Rhabdomyosarcoma (HP:0002859)1.78745344
151Abnormality of vitamin B metabolism (HP:0004340)1.78004207
152Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77549813
153Absent epiphyses (HP:0010577)1.77549813
154Molar tooth sign on MRI (HP:0002419)1.77350887
155Abnormality of midbrain morphology (HP:0002418)1.77350887
156Recurrent viral infections (HP:0004429)1.76948501
157Ependymoma (HP:0002888)1.76870144
158Mitochondrial inheritance (HP:0001427)1.74897127
159Abnormality of the proximal phalanges of the hand (HP:0009834)1.74597127
160Atresia of the external auditory canal (HP:0000413)1.74493261
161Leukopenia (HP:0001882)1.74343351
162Gaze-evoked nystagmus (HP:0000640)1.74212038
163Hypoplasia of the radius (HP:0002984)1.74091011
164IgG deficiency (HP:0004315)1.73472998
165Neutropenia (HP:0001875)1.72733504
166* Cleft eyelid (HP:0000625)1.71857132
167Parakeratosis (HP:0001036)1.71045445
168Muscle fiber atrophy (HP:0100295)1.69877271

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.95182359
2WEE13.94337870
3BUB13.88338593
4VRK23.38773644
5TAOK33.19570075
6STK163.07909737
7EIF2AK12.95795108
8VRK12.65342828
9NME22.61696778
10SRPK12.61573558
11GRK12.57200805
12FRK2.54264012
13TLK12.40870171
14NEK22.27135310
15PLK42.19445841
16TAF12.01983057
17GRK62.00566299
18MKNK11.97367264
19EIF2AK31.89796420
20TTK1.86512287
21MAP4K21.83989416
22ACVR1B1.82248189
23PLK11.80519032
24BRSK21.78474905
25TSSK61.75201890
26CDK71.74048820
27ATR1.73792603
28PINK11.67162974
29MKNK21.64849036
30TESK21.63320717
31AURKB1.56451614
32CCNB11.55780630
33DYRK31.52364270
34PBK1.51583179
35PRKD21.49434536
36ZAK1.49262722
37STK41.41311654
38PASK1.40219721
39BMPR1B1.38398929
40CHEK21.34880911
41NEK11.34183485
42CDK191.29486203
43PIM21.27730703
44IRAK41.26701215
45EIF2AK21.25050949
46CDK81.23219418
47PLK31.22135795
48CLK11.20329520
49MAP4K11.19205355
50BRSK11.17772381
51CDK41.12559037
52RPS6KB21.11300991
53RPS6KA41.10221146
54TXK1.07976011
55BCKDK1.04251590
56CHEK11.02642167
57ITK1.02596495
58AURKA1.01617621
59YES10.99298772
60TEC0.96970990
61PIM10.93638042
62SCYL20.91633889
63BLK0.89255840
64MAP3K80.87959594
65STK100.84962139
66FES0.84938269
67MST40.82826861
68MAP3K140.81214964
69IRAK30.80698410
70ATM0.78906485
71KIT0.77507947
72DAPK10.75237607
73BTK0.75169570
74RPS6KA50.75022441
75INSRR0.74521743
76CSNK2A10.73593599
77PAK40.73074193
78CSNK2A20.70327093
79MAPK130.69348599
80RIPK40.69297584
81BRD40.68923469
82CDK20.67328556
83EPHA20.63975488
84DAPK20.62299059
85CDK120.61982146
86PRKCQ0.60886481
87BMPR20.58824241
88MAPKAPK50.57072183
89CSF1R0.56425988
90FLT30.56287526
91IKBKE0.56242849
92SIK30.56194470
93TNK20.55501731
94HCK0.52476469
95MAP2K20.52469267
96DYRK20.52337540
97CSNK1G10.52022985
98CDK10.51972742
99PAK10.50912448
100IKBKB0.50438844
101NLK0.48645122
102TNIK0.48063150
103DAPK30.48052952
104LYN0.46411676
105MAPK40.45665498
106MAPKAPK30.45301080
107JAK30.45225717
108TGFBR10.44639968
109KDR0.44513649
110BRAF0.44214418
111MAP3K110.43369501
112CSNK1A1L0.43227867
113MAP2K30.42696045
114WNK30.41580737
115MATK0.41307412
116MELK0.40866979
117CSNK1G30.40483567
118PIK3CG0.40371932
119TYK20.39246743
120NME10.38377649
121CDK60.38119367
122ZAP700.35520644
123CSNK1G20.35313310
124TAOK20.34544291
125MAP3K100.33982692
126ABL20.33534835
127PRKCI0.33028950
128BCR0.32209064
129SYK0.30462064
130CDK30.29607555
131MARK30.29464493
132ADRBK20.27930786
133ILK0.27732407
134LCK0.26626883
135NUAK10.26357632

Predicted pathways (KEGG)

RankGene SetZ-score
1* DNA replication_Homo sapiens_hsa030305.24255808
2Mismatch repair_Homo sapiens_hsa034304.50998740
3Ribosome_Homo sapiens_hsa030103.78608152
4Homologous recombination_Homo sapiens_hsa034403.42530883
5Proteasome_Homo sapiens_hsa030503.38533206
6Base excision repair_Homo sapiens_hsa034103.18074095
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.09532356
8Spliceosome_Homo sapiens_hsa030403.06227930
9RNA polymerase_Homo sapiens_hsa030202.92234724
10Nucleotide excision repair_Homo sapiens_hsa034202.80203018
11Fanconi anemia pathway_Homo sapiens_hsa034602.58760264
12Non-homologous end-joining_Homo sapiens_hsa034502.55921408
13Pyrimidine metabolism_Homo sapiens_hsa002402.49578229
14Cell cycle_Homo sapiens_hsa041102.44865161
15RNA transport_Homo sapiens_hsa030132.44636515
16One carbon pool by folate_Homo sapiens_hsa006702.17721525
17Basal transcription factors_Homo sapiens_hsa030221.93617675
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91589742
19RNA degradation_Homo sapiens_hsa030181.78686887
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65550285
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59790029
22p53 signaling pathway_Homo sapiens_hsa041151.37506088
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37002483
24Phototransduction_Homo sapiens_hsa047441.36412571
25Purine metabolism_Homo sapiens_hsa002301.34528281
26Protein export_Homo sapiens_hsa030601.32192910
27mRNA surveillance pathway_Homo sapiens_hsa030151.28389230
28Systemic lupus erythematosus_Homo sapiens_hsa053221.21453776
29Sulfur metabolism_Homo sapiens_hsa009201.17600797
30Folate biosynthesis_Homo sapiens_hsa007901.11287627
31Primary immunodeficiency_Homo sapiens_hsa053401.11284115
32Epstein-Barr virus infection_Homo sapiens_hsa051691.07854666
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06831165
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06724406
35Herpes simplex infection_Homo sapiens_hsa051681.05958093
36Type I diabetes mellitus_Homo sapiens_hsa049401.03589720
37Vitamin digestion and absorption_Homo sapiens_hsa049770.98424502
38Antigen processing and presentation_Homo sapiens_hsa046120.91398691
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91391440
40Melanoma_Homo sapiens_hsa052180.89215917
41Nitrogen metabolism_Homo sapiens_hsa009100.85364146
42Cardiac muscle contraction_Homo sapiens_hsa042600.84655327
43Parkinsons disease_Homo sapiens_hsa050120.83201697
44Chemical carcinogenesis_Homo sapiens_hsa052040.81305627
45Huntingtons disease_Homo sapiens_hsa050160.80943354
46Tryptophan metabolism_Homo sapiens_hsa003800.78308668
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.77800116
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73760801
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.73113461
50Oxidative phosphorylation_Homo sapiens_hsa001900.72759637
51Viral carcinogenesis_Homo sapiens_hsa052030.72163346
52Measles_Homo sapiens_hsa051620.69429516
53Allograft rejection_Homo sapiens_hsa053300.67953197
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65464558
55Nicotine addiction_Homo sapiens_hsa050330.62722978
56Peroxisome_Homo sapiens_hsa041460.60698256
57Glutathione metabolism_Homo sapiens_hsa004800.60280253
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.60143033
59HTLV-I infection_Homo sapiens_hsa051660.59256711
60Asthma_Homo sapiens_hsa053100.58542121
61Hematopoietic cell lineage_Homo sapiens_hsa046400.58197535
62Pentose phosphate pathway_Homo sapiens_hsa000300.57350534
63Autoimmune thyroid disease_Homo sapiens_hsa053200.55688967
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54746949
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54729746
66Legionellosis_Homo sapiens_hsa051340.54146893
67T cell receptor signaling pathway_Homo sapiens_hsa046600.52545243
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51721130
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51712097
70Graft-versus-host disease_Homo sapiens_hsa053320.51482212
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51066425
72Sulfur relay system_Homo sapiens_hsa041220.51032918
73Taste transduction_Homo sapiens_hsa047420.50340461
74Arachidonic acid metabolism_Homo sapiens_hsa005900.46103100
75B cell receptor signaling pathway_Homo sapiens_hsa046620.45504659
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44831970
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43859853
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43214410
79Apoptosis_Homo sapiens_hsa042100.43118859
80Vitamin B6 metabolism_Homo sapiens_hsa007500.42079569
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41291104
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.41045230
83Regulation of autophagy_Homo sapiens_hsa041400.39970321
84Small cell lung cancer_Homo sapiens_hsa052220.39746512
85N-Glycan biosynthesis_Homo sapiens_hsa005100.39725847
86Glycerolipid metabolism_Homo sapiens_hsa005610.39632947
87Selenocompound metabolism_Homo sapiens_hsa004500.39534459
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39471755
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.39293672
90Olfactory transduction_Homo sapiens_hsa047400.38232199
91Staphylococcus aureus infection_Homo sapiens_hsa051500.37397860
92Morphine addiction_Homo sapiens_hsa050320.37160701
93Oocyte meiosis_Homo sapiens_hsa041140.37131410
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.36226343
95Shigellosis_Homo sapiens_hsa051310.36195170
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36183363
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34853063
98Rheumatoid arthritis_Homo sapiens_hsa053230.34084956
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33130548
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.32906047
101Other glycan degradation_Homo sapiens_hsa005110.32646108
102Alcoholism_Homo sapiens_hsa050340.32506855
103Metabolic pathways_Homo sapiens_hsa011000.32446112
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32162154
105Retinol metabolism_Homo sapiens_hsa008300.31530881
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31126661
107Hepatitis B_Homo sapiens_hsa051610.31074879
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31061754
109Leishmaniasis_Homo sapiens_hsa051400.28406479
110Calcium signaling pathway_Homo sapiens_hsa040200.28072301
111Influenza A_Homo sapiens_hsa051640.27957415
112MicroRNAs in cancer_Homo sapiens_hsa052060.27558595
113Caffeine metabolism_Homo sapiens_hsa002320.25197889
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25083159
115Alzheimers disease_Homo sapiens_hsa050100.25047855
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22822172
117Renin-angiotensin system_Homo sapiens_hsa046140.21872721
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18988615
119Sphingolipid metabolism_Homo sapiens_hsa006000.18346751
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18196973
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.17254960
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.17030989
123Malaria_Homo sapiens_hsa051440.15452889
124Biosynthesis of amino acids_Homo sapiens_hsa012300.14938447
125Arginine and proline metabolism_Homo sapiens_hsa003300.13083542
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.12944493
127Notch signaling pathway_Homo sapiens_hsa043300.12400192
128Thyroid cancer_Homo sapiens_hsa052160.12065378
129Pathways in cancer_Homo sapiens_hsa052000.12061964
130Colorectal cancer_Homo sapiens_hsa052100.09133587
131Linoleic acid metabolism_Homo sapiens_hsa005910.08822187
132Viral myocarditis_Homo sapiens_hsa054160.08156007

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