RNASEL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of memory T cell differentiation (GO:0043380)5.67660690
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.32228597
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.15334847
4negative regulation of cell killing (GO:0031342)5.15334847
5regulation of B cell receptor signaling pathway (GO:0050855)4.42889333
6regulation of MHC class I biosynthetic process (GO:0045343)4.37289169
7negative regulation of type 2 immune response (GO:0002829)4.29465233
8production of molecular mediator involved in inflammatory response (GO:0002532)4.07245152
9positive regulation of interleukin-1 secretion (GO:0050716)4.05954029
10positive regulation by symbiont of host defense response (GO:0052509)3.98427647
11modulation by symbiont of host defense response (GO:0052031)3.98427647
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.98427647
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.98427647
14positive regulation by organism of defense response of other organism involved in symbiotic interact3.98427647
15modulation by symbiont of host immune response (GO:0052553)3.98427647
16cellular extravasation (GO:0045123)3.92895922
17positive regulation of gamma-delta T cell activation (GO:0046645)3.91888801
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.88915796
19regulation of gamma-delta T cell differentiation (GO:0045586)3.76784656
20negative regulation of lymphocyte mediated immunity (GO:0002707)3.71310482
21response to interleukin-15 (GO:0070672)3.62940925
22maintenance of gastrointestinal epithelium (GO:0030277)3.58269970
23cellular response to interleukin-15 (GO:0071350)3.58246668
24negative regulation of interleukin-12 production (GO:0032695)3.57055305
25regulation of interferon-beta biosynthetic process (GO:0045357)3.56554111
26hepatocyte apoptotic process (GO:0097284)3.51770786
27germinal center formation (GO:0002467)3.50354208
28negative regulation of T cell mediated immunity (GO:0002710)3.50213325
29definitive hemopoiesis (GO:0060216)3.48044803
30doxorubicin metabolic process (GO:0044598)3.46710623
31daunorubicin metabolic process (GO:0044597)3.46710623
32polyketide metabolic process (GO:0030638)3.46710623
33lymphocyte chemotaxis (GO:0048247)3.46415176
34positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.46382075
35defense response to protozoan (GO:0042832)3.40778667
36regulation of establishment of cell polarity (GO:2000114)3.40717664
37regulation of interleukin-1 secretion (GO:0050704)3.40354990
38macrophage activation involved in immune response (GO:0002281)3.35874543
39neural tube formation (GO:0001841)3.35818374
40regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.33755806
41response to muramyl dipeptide (GO:0032495)3.33530465
42neutrophil activation involved in immune response (GO:0002283)3.32419353
43B cell receptor signaling pathway (GO:0050853)3.20067066
44neutrophil activation (GO:0042119)3.19746278
45* response to type I interferon (GO:0034340)3.19022770
46positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.18899404
47respiratory burst (GO:0045730)3.18668299
48response to peptidoglycan (GO:0032494)3.18085780
49response to protozoan (GO:0001562)3.17253383
50regulation of T cell tolerance induction (GO:0002664)3.15158236
51antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.14748309
52antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.14748309
53negative thymic T cell selection (GO:0045060)3.12995980
54negative T cell selection (GO:0043383)3.10452917
55detection of molecule of bacterial origin (GO:0032490)3.10069521
56* cellular response to type I interferon (GO:0071357)3.09757144
57* type I interferon signaling pathway (GO:0060337)3.09757144
58B cell homeostasis (GO:0001782)3.08705820
59macrophage activation (GO:0042116)3.08659625
60T cell migration (GO:0072678)3.07669838
61negative regulation of granulocyte differentiation (GO:0030853)3.07486334
62negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.07058820
63cellular response to ethanol (GO:0071361)3.06610847
64immunoglobulin mediated immune response (GO:0016064)3.05577112
65leukocyte aggregation (GO:0070486)3.05479377
66detection of bacterium (GO:0016045)3.04684741
67neutrophil mediated immunity (GO:0002446)3.04509853
68interferon-gamma production (GO:0032609)3.03976545
69positive regulation of interleukin-1 production (GO:0032732)3.03882674
70dendritic cell chemotaxis (GO:0002407)3.03087764
71positive regulation of interleukin-1 beta secretion (GO:0050718)3.02093222
72megakaryocyte development (GO:0035855)3.01716829
73negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.01108848
74positive regulation of interferon-alpha production (GO:0032727)3.00783483
75mast cell activation (GO:0045576)3.00711628
76interferon-gamma-mediated signaling pathway (GO:0060333)2.99837605
77negative regulation of leukocyte mediated immunity (GO:0002704)2.99405223
78myeloid leukocyte mediated immunity (GO:0002444)2.98083580
79regulation of T cell mediated cytotoxicity (GO:0001914)2.97296525
80response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.96970986
81response to host immune response (GO:0052572)2.96970986
82antigen processing and presentation of endogenous antigen (GO:0019883)2.95372134
83dendritic cell migration (GO:0036336)2.93170807
84myeloid cell activation involved in immune response (GO:0002275)2.91999996
85cytoplasmic mRNA processing body assembly (GO:0033962)2.89400551
86positive regulation of B cell differentiation (GO:0045579)2.89256455
87positive regulation of mast cell activation (GO:0033005)2.89007556
88CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.88998178
89granulocyte activation (GO:0036230)2.88806374
90negative regulation of adaptive immune response (GO:0002820)2.87959855
91myeloid dendritic cell activation (GO:0001773)2.85189347
92G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.84945839
93regulation of interferon-alpha production (GO:0032647)2.84825038
94detection of other organism (GO:0098543)2.84415007
95regulation of mast cell activation involved in immune response (GO:0033006)2.84201747
96amyloid precursor protein catabolic process (GO:0042987)2.83178580
97establishment of protein localization to Golgi (GO:0072600)2.83001388
98JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.82316210
99regulation of establishment or maintenance of cell polarity (GO:0032878)2.80770305
100regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.80392570
101regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.80165029
102regulation of B cell differentiation (GO:0045577)2.80041607
103regulation of mast cell degranulation (GO:0043304)2.79854900
104detection of biotic stimulus (GO:0009595)2.79731799
105positive regulation of T cell mediated cytotoxicity (GO:0001916)2.78687504
106lymphocyte homeostasis (GO:0002260)2.78663700
107regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.77712100
108lipopolysaccharide-mediated signaling pathway (GO:0031663)2.76727910
109negative regulation of phagocytosis (GO:0050765)2.75516919
110positive regulation of granulocyte differentiation (GO:0030854)2.74671108
111regulation of regulatory T cell differentiation (GO:0045589)2.74650553
112negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.73686863
113negative regulation of T-helper cell differentiation (GO:0045623)2.73686863
114histamine secretion (GO:0001821)2.69967195
115regulation of gamma-delta T cell activation (GO:0046643)2.69675494
116erythrocyte maturation (GO:0043249)2.69616404
117negative regulation of immunoglobulin mediated immune response (GO:0002890)2.69157031
118negative regulation of B cell mediated immunity (GO:0002713)2.69157031
119regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.69080315
120detection of external biotic stimulus (GO:0098581)2.69067310
121T cell homeostasis (GO:0043029)2.67069297
122negative regulation of protein tyrosine kinase activity (GO:0061099)2.66907740
123pinocytosis (GO:0006907)2.66544369
124leukotriene metabolic process (GO:0006691)2.65735345
125response to pheromone (GO:0019236)2.65009170
126activated T cell proliferation (GO:0050798)2.64387952
127response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.64198984
128response to host (GO:0075136)2.64198984
129response to host defenses (GO:0052200)2.64198984
130positive regulation of macrophage differentiation (GO:0045651)2.64076505
131microglial cell activation (GO:0001774)2.64018015
132leukocyte cell-cell adhesion (GO:0007159)2.64013216
133regulation of interleukin-1 beta secretion (GO:0050706)2.62827976
134mature B cell differentiation (GO:0002335)2.61395531
135leukocyte migration involved in inflammatory response (GO:0002523)2.61390846
136regulation of type 2 immune response (GO:0002828)2.60570102
137regulation of RIG-I signaling pathway (GO:0039535)2.59755499
138mature B cell differentiation involved in immune response (GO:0002313)2.59743623
139regulation of alpha-beta T cell proliferation (GO:0046640)2.58906291
140regulation of mast cell activation (GO:0033003)2.58805774
141epithelial structure maintenance (GO:0010669)2.58001054
142positive T cell selection (GO:0043368)2.57598742
143positive thymic T cell selection (GO:0045059)2.55745026
144regulation of antigen processing and presentation (GO:0002577)2.54837639
145protein targeting to Golgi (GO:0000042)2.54304917
146antigen processing and presentation via MHC class Ib (GO:0002475)2.53331651

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.53407043
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.91303320
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.31945362
4GATA1_22025678_ChIP-Seq_K562_Human4.15429050
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.13090283
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.07716746
7SCL_19346495_ChIP-Seq_HPC-7_Human4.07233183
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.89584985
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.69974282
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.49014526
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.43208565
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.10089841
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.06682995
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.95883386
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.91380682
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.61097188
17RUNX_20019798_ChIP-Seq_JUKART_Human2.55141001
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.44597198
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41210741
20* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.31754270
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.28961761
22VDR_21846776_ChIP-Seq_THP-1_Human2.25448043
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.17197901
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.14507910
25RUNX1_22412390_ChIP-Seq_EML_Mouse2.13303856
26VDR_24763502_ChIP-Seq_THP-1_Human2.12623832
27SPI1_23547873_ChIP-Seq_NB4_Human2.10160051
28SPI1_23127762_ChIP-Seq_K562_Human2.00535490
29LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.98534594
30* MYB_26560356_Chip-Seq_TH2_Human1.98042110
31* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.94556180
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82219348
33VDR_22108803_ChIP-Seq_LS180_Human1.75278253
34GATA1_19941827_ChIP-Seq_MEL_Mouse1.73336144
35ER_23166858_ChIP-Seq_MCF-7_Human1.72754398
36MAF_26560356_Chip-Seq_TH1_Human1.69048914
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68634401
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67590470
39VDR_24787735_ChIP-Seq_THP-1_Human1.66487491
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.66331393
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66096625
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.65966872
43CDX2_20551321_ChIP-Seq_CACO-2_Human1.65274903
44* MYB_26560356_Chip-Seq_TH1_Human1.63545852
45E2F7_22180533_ChIP-Seq_HELA_Human1.63473337
46GBX2_23144817_ChIP-Seq_PC3_Human1.62143086
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.60716799
48TAF15_26573619_Chip-Seq_HEK293_Human1.56842564
49GATA2_19941826_ChIP-Seq_K562_Human1.56477581
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56163972
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.53848437
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52625169
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49939337
54* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.49596749
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.49409537
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47501026
57BCAT_22108803_ChIP-Seq_LS180_Human1.47419226
58UTX_26944678_Chip-Seq_JUKART_Human1.46103495
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45862481
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44310069
61* PU_27001747_Chip-Seq_BMDM_Mouse1.43928862
62TCF7_22412390_ChIP-Seq_EML_Mouse1.42309154
63* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41579157
64* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40224558
65* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39596096
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.38735963
67GATA1_19941826_ChIP-Seq_K562_Human1.37538299
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36034319
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34283808
70* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31892761
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31167037
72RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.28129733
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27870977
74TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26887340
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26379996
76IGF1R_20145208_ChIP-Seq_DFB_Human1.24696206
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.23014086
78ZNF274_21170338_ChIP-Seq_K562_Hela1.22854574
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22436140
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21344679
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17477093
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.17125826
83* CDX2_22108803_ChIP-Seq_LS180_Human1.15946283
84STAT3_23295773_ChIP-Seq_U87_Human1.15853714
85FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15744481
86* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15731901
87* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.15654693
88PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15493882
89GATA3_27048872_Chip-Seq_THYMUS_Human1.14995771
90* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14844386
91* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12465324
92CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11676566
93* EZH2_27294783_Chip-Seq_NPCs_Mouse1.11650037
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08885072
95TCF4_23295773_ChIP-Seq_U87_Human1.08735892
96ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08236709
97ESR1_20079471_ChIP-ChIP_T-47D_Human1.08202710
98GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06780635
99FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06592586
100TP63_19390658_ChIP-ChIP_HaCaT_Human1.06245102
101* NFE2_27457419_Chip-Seq_LIVER_Mouse1.04277893
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04264623
103* SOX2_20726797_ChIP-Seq_SW620_Human1.04142258
104GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.03513675
105NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03501366
106* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02182267
107TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.01911266
108TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01381011
109CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00908301
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00584791
111VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00574159
112CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00411877
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00155953
114P300_19829295_ChIP-Seq_ESCs_Human0.99900426
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99643025
116AHR_22903824_ChIP-Seq_MCF-7_Human0.99561847
117SMAD4_21799915_ChIP-Seq_A2780_Human0.99368105
118* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98755968
119NOTCH1_21737748_ChIP-Seq_TLL_Human0.98641738
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.97585578
121MYC_22102868_ChIP-Seq_BL_Human0.97377899
122* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96730511
123* CRX_20693478_ChIP-Seq_RETINA_Mouse0.95664324
124CBP_20019798_ChIP-Seq_JUKART_Human0.95410550
125IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95410550
126* NANOG_18555785_Chip-Seq_ESCs_Mouse0.94144354
127FLI1_21867929_ChIP-Seq_TH2_Mouse0.93747018
128PIAS1_25552417_ChIP-Seq_VCAP_Human0.93066199
129* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92951092
130AR_25329375_ChIP-Seq_VCAP_Human0.92188638
131GATA6_25053715_ChIP-Seq_YYC3_Human0.90408110
132NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88657224
133SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87958082
134THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87531626
135TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.81842181
136GATA3_26560356_Chip-Seq_TH2_Human0.79947746
137HOXB4_20404135_ChIP-ChIP_EML_Mouse0.78857913
138* GATA4_25053715_ChIP-Seq_YYC3_Human0.77612887
139* MAF_26560356_Chip-Seq_TH2_Human0.76926650
140KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.74669379
141PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.72834639
142SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.72761627
143TP63_17297297_ChIP-ChIP_HaCaT_Human0.72407029
144ETS1_22383799_ChIP-Seq_G1ME_Mouse0.72045386
145* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.71774783
146SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.71227852
147SMRT_27268052_Chip-Seq_Bcells_Human0.70848522
148SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.69578285
149* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69490104
150SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69440379
151SALL4_22934838_ChIP-ChIP_CD34+_Human0.68984630
152KDM2B_26808549_Chip-Seq_SUP-B15_Human0.66256264
153JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64717347

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.59038909
2MP0005671_abnormal_response_to3.10497894
3MP0009785_altered_susceptibility_to2.92983093
4MP0001873_stomach_inflammation2.92440849
5MP0002396_abnormal_hematopoietic_system2.82786310
6MP0005257_abnormal_intraocular_pressure2.82171322
7MP0003436_decreased_susceptibility_to2.68555692
8MP0002148_abnormal_hypersensitivity_rea2.56750092
9* MP0005025_abnormal_response_to2.48350479
10MP0003724_increased_susceptibility_to2.45541340
11MP0002419_abnormal_innate_immunity2.43897342
12MP0000685_abnormal_immune_system2.42183098
13MP0005000_abnormal_immune_tolerance2.42055563
14MP0010155_abnormal_intestine_physiology2.41685398
15MP0001800_abnormal_humoral_immune2.39046973
16MP0002452_abnormal_antigen_presenting2.38779980
17MP0006054_spinal_hemorrhage2.37418120
18MP0005464_abnormal_platelet_physiology2.37259897
19MP0003866_abnormal_defecation2.30488376
20MP0000569_abnormal_digit_pigmentation2.30133998
21MP0000490_abnormal_crypts_of2.28136579
22MP0005174_abnormal_tail_pigmentation2.26266017
23MP0005058_abnormal_lysosome_morphology2.24452599
24MP0002723_abnormal_immune_serum2.24034265
25* MP0001819_abnormal_immune_cell2.23634544
26MP0003252_abnormal_bile_duct2.23500286
27* MP0002420_abnormal_adaptive_immunity2.20497673
28MP0005387_immune_system_phenotype2.08638311
29MP0001790_abnormal_immune_system2.08638311
30MP0000465_gastrointestinal_hemorrhage2.05951271
31MP0004381_abnormal_hair_follicle2.00310132
32MP0003300_gastrointestinal_ulcer1.95146180
33MP0002398_abnormal_bone_marrow1.92378616
34MP0005377_hearing/vestibular/ear_phenot1.85826572
35MP0003878_abnormal_ear_physiology1.85826572
36MP0003195_calcinosis1.82234903
37MP0003011_delayed_dark_adaptation1.82010205
38MP0004947_skin_inflammation1.79946032
39MP0001663_abnormal_digestive_system1.76392933
40MP0003303_peritoneal_inflammation1.74926528
41MP0000716_abnormal_immune_system1.73454959
42MP0006082_CNS_inflammation1.70918808
43MP0002166_altered_tumor_susceptibility1.70147515
44MP0001986_abnormal_taste_sensitivity1.70013918
45MP0003763_abnormal_thymus_physiology1.69262807
46MP0005310_abnormal_salivary_gland1.67034537
47MP0001845_abnormal_inflammatory_respons1.65777152
48MP0004147_increased_porphyrin_level1.63034008
49MP0005075_abnormal_melanosome_morpholog1.61784990
50MP0002405_respiratory_system_inflammati1.57560348
51MP0003191_abnormal_cellular_cholesterol1.56238362
52MP0003656_abnormal_erythrocyte_physiolo1.55929415
53MP0002277_abnormal_respiratory_mucosa1.53626725
54MP0002006_tumorigenesis1.52946483
55MP0009333_abnormal_splenocyte_physiolog1.51101369
56MP0002429_abnormal_blood_cell1.47823919
57* MP0002722_abnormal_immune_system1.46857113
58MP0000689_abnormal_spleen_morphology1.46033110
59MP0000015_abnormal_ear_pigmentation1.44104416
60MP0000371_diluted_coat_color1.44047666
61MP0001533_abnormal_skeleton_physiology1.34386497
62MP0005167_abnormal_blood-brain_barrier1.30634215
63MP0002132_abnormal_respiratory_system1.28565077
64MP0005397_hematopoietic_system_phenotyp1.28253693
65MP0001545_abnormal_hematopoietic_system1.28253693
66MP0002138_abnormal_hepatobiliary_system1.28179694
67MP0003183_abnormal_peptide_metabolism1.27761140
68MP0008057_abnormal_DNA_replication1.27698881
69MP0004808_abnormal_hematopoietic_stem1.25914321
70MP0004883_abnormal_blood_vessel1.24826623
71MP0005381_digestive/alimentary_phenotyp1.23956551
72MP0002095_abnormal_skin_pigmentation1.18576657
73MP0009278_abnormal_bone_marrow1.15746594
74MP0002876_abnormal_thyroid_physiology1.14528371
75MP0001851_eye_inflammation1.14147736
76MP0008260_abnormal_autophagy1.13493969
77MP0000343_altered_response_to1.12936143
78MP0000477_abnormal_intestine_morphology1.12898474
79MP0002998_abnormal_bone_remodeling1.11910679
80MP0003045_fibrosis1.10720646
81MP0008469_abnormal_protein_level1.09112899
82MP0009764_decreased_sensitivity_to1.08002404
83MP0004130_abnormal_muscle_cell1.07267900
84MP0002822_catalepsy1.07250163
85MP0001853_heart_inflammation1.07019872
86MP0001501_abnormal_sleep_pattern1.06668437
87MP0005166_decreased_susceptibility_to1.06625271
88MP0004264_abnormal_extraembryonic_tissu1.05368490
89MP0008877_abnormal_DNA_methylation1.01103865
90* MP0000703_abnormal_thymus_morphology0.98857867
91MP0005164_abnormal_response_to0.97507728
92MP0000427_abnormal_hair_cycle0.94030965
93MP0002928_abnormal_bile_duct0.94029258
94MP0010386_abnormal_urinary_bladder0.90684259
95MP0002693_abnormal_pancreas_physiology0.90429820
96MP0005409_darkened_coat_color0.89465721
97MP0003868_abnormal_feces_composition0.88573714
98MP0001664_abnormal_digestion0.87276915
99MP0003690_abnormal_glial_cell0.86000358
100MP0003448_altered_tumor_morphology0.84560462
101MP0004510_myositis0.83550744
102MP0000858_altered_metastatic_potential0.83454114
103MP0003787_abnormal_imprinting0.80831869
104MP0008873_increased_physiological_sensi0.80217422
105MP0005253_abnormal_eye_physiology0.77925812
106MP0000681_abnormal_thyroid_gland0.77416989
107MP0003795_abnormal_bone_structure0.77292376
108MP0005085_abnormal_gallbladder_physiolo0.76897585
109MP0003828_pulmonary_edema0.75568467
110MP0004484_altered_response_of0.75529607
111MP0005083_abnormal_biliary_tract0.74515038
112MP0009763_increased_sensitivity_to0.74333562
113MP0008004_abnormal_stomach_pH0.72514232
114MP0009115_abnormal_fat_cell0.72436054
115MP0001666_abnormal_nutrient_absorption0.71479474
116MP0002933_joint_inflammation0.70885958
117MP0003172_abnormal_lysosome_physiology0.69779814
118MP0001968_abnormal_touch/_nociception0.69334446
119MP0000372_irregular_coat_pigmentation0.67755509
120MP0002009_preneoplasia0.67668249
121MP0000470_abnormal_stomach_morphology0.66977895
122MP0002089_abnormal_postnatal_growth/wei0.66560678
123MP0005670_abnormal_white_adipose0.65101730
124MP0000249_abnormal_blood_vessel0.64829262
125MP0002736_abnormal_nociception_after0.64505362
126MP0003646_muscle_fatigue0.61552736
127MP0003075_altered_response_to0.61534427
128MP0000604_amyloidosis0.61152705
129MP0005376_homeostasis/metabolism_phenot0.60981177
130MP0010307_abnormal_tumor_latency0.60712470
131MP0004043_abnormal_pH_regulation0.60700443
132MP0005390_skeleton_phenotype0.60208270
133MP0010352_gastrointestinal_tract_polyps0.60093227
134MP0002168_other_aberrant_phenotype0.57584150

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.64182551
2Recurrent bacterial skin infections (HP:0005406)5.29827402
3Eczematoid dermatitis (HP:0000976)4.97642216
4Genetic anticipation (HP:0003743)4.47084821
5Spinal cord lesions (HP:0100561)4.30724404
6Syringomyelia (HP:0003396)4.30724404
7Stomatitis (HP:0010280)4.09879297
8Recurrent cutaneous fungal infections (HP:0011370)4.00988432
9Chronic mucocutaneous candidiasis (HP:0002728)4.00988432
10Recurrent fungal infections (HP:0002841)3.94487120
11Metaphyseal dysplasia (HP:0100255)3.87333582
12Vacuolated lymphocytes (HP:0001922)3.85166434
13Pustule (HP:0200039)3.85067995
14Recurrent skin infections (HP:0001581)3.82990933
15Myositis (HP:0100614)3.79000532
16Hypochromic microcytic anemia (HP:0004840)3.69148569
17Petechiae (HP:0000967)3.58756804
18Abnormality of macrophages (HP:0004311)3.55249929
19Chronic diarrhea (HP:0002028)3.51092292
20Absent frontal sinuses (HP:0002688)3.49895617
21Dysmetric saccades (HP:0000641)3.40632080
22Elevated erythrocyte sedimentation rate (HP:0003565)3.30093173
23Agnosia (HP:0010524)3.29023806
24Cheilitis (HP:0100825)3.26264034
25Gastrointestinal infarctions (HP:0005244)3.24188225
26Prolonged bleeding time (HP:0003010)3.21062090
27Gaze-evoked nystagmus (HP:0000640)3.19652110
28Mediastinal lymphadenopathy (HP:0100721)3.17193755
29Slow saccadic eye movements (HP:0000514)3.16103975
30Orchitis (HP:0100796)3.14194361
31Recurrent viral infections (HP:0004429)3.08503492
32Retrobulbar optic neuritis (HP:0100654)3.07654838
33Optic neuritis (HP:0100653)3.07654838
34Disinhibition (HP:0000734)3.06988933
35Recurrent gram-negative bacterial infections (HP:0005420)3.05868425
36Autoimmune thrombocytopenia (HP:0001973)3.01008693
37Progressive cerebellar ataxia (HP:0002073)2.99932647
38Chest pain (HP:0100749)2.93086729
39IgM deficiency (HP:0002850)2.91124742
40Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.83825071
41Periodontitis (HP:0000704)2.76992298
42Meningitis (HP:0001287)2.76063131
43Chronic obstructive pulmonary disease (HP:0006510)2.70089068
44Obstructive lung disease (HP:0006536)2.70089068
45Gingivitis (HP:0000230)2.70016285
46Short middle phalanx of the 5th finger (HP:0004220)2.69306061
47Hypochromic anemia (HP:0001931)2.67480572
48Spondylolisthesis (HP:0003302)2.62774530
49Vasculitis (HP:0002633)2.62276830
50Recurrent bronchitis (HP:0002837)2.60368087
51Action tremor (HP:0002345)2.56211722
52Patchy hypopigmentation of hair (HP:0011365)2.50594304
53Poikilocytosis (HP:0004447)2.48588903
54Facial diplegia (HP:0001349)2.46270390
55Anorexia (HP:0002039)2.44887487
56Postural instability (HP:0002172)2.44505496
57Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.41172804
58Stomach cancer (HP:0012126)2.40991837
59Cellulitis (HP:0100658)2.40508858
60Recurrent pneumonia (HP:0006532)2.39391063
61Impaired platelet aggregation (HP:0003540)2.31127349
62Abnormal platelet function (HP:0011869)2.31127349
63Thickened calvaria (HP:0002684)2.28824981
64Epistaxis (HP:0000421)2.28197886
65Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.27217278
66Eosinophilia (HP:0001880)2.26739778
67Abnormality of T cell physiology (HP:0011840)2.24800281
68Keratoconjunctivitis (HP:0001096)2.24408452
69* Prostate neoplasm (HP:0100787)2.21396894
70Hemoptysis (HP:0002105)2.20552041
71Chronic otitis media (HP:0000389)2.20154161
72Abnormal delayed hypersensitivity skin test (HP:0002963)2.19713942
73Osteomyelitis (HP:0002754)2.17951641
74Keratoconjunctivitis sicca (HP:0001097)2.17917596
75Autoimmune hemolytic anemia (HP:0001890)2.16849573
76Pulmonary embolism (HP:0002204)2.15916274
77IgG deficiency (HP:0004315)2.14558196
78Abnormality of eosinophils (HP:0001879)2.14472577
79Leukocytosis (HP:0001974)2.14079939
80Microcytic anemia (HP:0001935)2.12641042
81Inflammation of the large intestine (HP:0002037)2.10987152
82Granulocytopenia (HP:0001913)2.10925024
83Increased neuronal autofluorescent lipopigment (HP:0002074)2.08736214
84Abnormality of the frontal sinuses (HP:0002687)2.05814197
85Increased cerebral lipofuscin (HP:0011813)2.04727299
86Pulmonary infiltrates (HP:0002113)2.02957973
87White forelock (HP:0002211)2.02305959
88Congenital stationary night blindness (HP:0007642)2.02033409
89Abnormality of T cells (HP:0002843)2.01489855
90Urinary bladder sphincter dysfunction (HP:0002839)2.01443117
91Recurrent lower respiratory tract infections (HP:0002783)2.01021604
92Abnormality of the hepatic vasculature (HP:0006707)1.99654213
93Progressive inability to walk (HP:0002505)1.99652788
94Lymphopenia (HP:0001888)1.99527835
95Loss of speech (HP:0002371)1.99285992
96Vertigo (HP:0002321)1.98576860
97Agammaglobulinemia (HP:0004432)1.97867150
98Oligomenorrhea (HP:0000876)1.97709415
99Abnormality of the pleura (HP:0002103)1.96556327
100Thrombocytosis (HP:0001894)1.96160416
101Gangrene (HP:0100758)1.95355458
102Spontaneous hematomas (HP:0007420)1.94954430
103Abnormality of the fingertips (HP:0001211)1.94656307
104Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.94214690
105* Abnormality of the prostate (HP:0008775)1.93948677
106Episodic fever (HP:0001954)1.92648921
107Keratitis (HP:0000491)1.90685656
108Thyroiditis (HP:0100646)1.90279435
109Gastrointestinal inflammation (HP:0004386)1.89541406
110Peritonitis (HP:0002586)1.88651664
111Gingival bleeding (HP:0000225)1.88646444
112Panhypogammaglobulinemia (HP:0003139)1.88600915
113T lymphocytopenia (HP:0005403)1.88465069
114Abnormality of cells of the lymphoid lineage (HP:0012140)1.87387959
115Hypoproteinemia (HP:0003075)1.87090224
116Urticaria (HP:0001025)1.86890422
117Congenital sensorineural hearing impairment (HP:0008527)1.86857899
118Acne (HP:0001061)1.86598656
119Hyperventilation (HP:0002883)1.86353949
120Polyneuropathy (HP:0001271)1.84237187
121Villous atrophy (HP:0011473)1.83911224
122Abnormality of small intestinal villus morphology (HP:0011472)1.83911224
123Pancreatic cysts (HP:0001737)1.83148860
124Macular degeneration (HP:0000608)1.82388487
125Arterial thrombosis (HP:0004420)1.81914590
126Absent/shortened dynein arms (HP:0200106)1.80875733
127Dynein arm defect of respiratory motile cilia (HP:0012255)1.80875733
128Hemiplegia (HP:0002301)1.80252439
129Inappropriate behavior (HP:0000719)1.80203653
130Sepsis (HP:0100806)1.80072159
131Abnormality of the phalanges of the 2nd finger (HP:0009541)1.79634794
132Systemic lupus erythematosus (HP:0002725)1.79532093
133Abnormality of T cell number (HP:0011839)1.78680278
134Recurrent sinusitis (HP:0011108)1.78152962
135Abnormality of glycolipid metabolism (HP:0010969)1.78051608
136Abnormality of liposaccharide metabolism (HP:0010968)1.78051608
137Abnormality of glycosphingolipid metabolism (HP:0004343)1.78051608
138Abnormality of the renal cortex (HP:0011035)1.77929701
139Bone pain (HP:0002653)1.77398170
140Abnormality of B cell number (HP:0010975)1.76485447
141B lymphocytopenia (HP:0010976)1.76485447
142Abnormality of the parietal bone (HP:0002696)1.75559571
143Gastrointestinal stroma tumor (HP:0100723)1.73008588
144Abnormal platelet volume (HP:0011876)1.72683903
145Ectropion (HP:0000656)1.72521198
146Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.72519308
147Encephalitis (HP:0002383)1.69482839
148Purpura (HP:0000979)1.69386915

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.98119907
2PIK3CA4.32588690
3CDK192.76604065
4MAP4K12.54419101
5KIT2.53047648
6TXK2.52727910
7MAP3K142.34129231
8SIK32.29436741
9BLK2.27913922
10CLK12.23146791
11OXSR12.13560097
12TNK22.07008045
13IRAK42.06358251
14JAK32.03778300
15TAOK31.92707014
16TYK21.88531447
17MAP3K21.80229672
18RIPK41.78300754
19IKBKE1.74358702
20SIK21.72049522
21IRAK31.71502717
22TBK11.67430138
23EEF2K1.66783213
24TEC1.63801957
25MAP2K21.63404254
26MATK1.43200371
27GRK11.43097559
28TGFBR21.41533026
29MET1.37678751
30ZAP701.36773272
31PTK2B1.35101480
32MAP3K71.31476105
33BTK1.30763385
34CDK91.30724305
35SYK1.30603955
36BMPR1B1.28769331
37CSF1R1.24340033
38FGFR31.21360684
39PIK3CG1.16853193
40FGR1.14596313
41IKBKB1.12188060
42MAP3K101.11006796
43LCK1.09831191
44GRK61.09463204
45ITK1.06124101
46PINK11.05982781
47BMPR21.03642307
48JAK11.03155114
49LYN1.03132824
50MAP3K131.02093660
51TRPM70.96456510
52PIM10.93765804
53FRK0.93044073
54FGFR40.92970195
55STK100.92244257
56FLT30.89943841
57HIPK20.88585504
58YES10.88447046
59NEK90.87358226
60CAMKK20.86598003
61MAP4K20.86496135
62MAP3K60.85262421
63CHUK0.84726669
64HCK0.84049342
65JAK20.82352103
66MAP2K30.81219246
67CSK0.80737389
68NUAK10.77771611
69MAPK130.77227166
70TGFBR10.76116471
71MAPK110.75305774
72MAPK40.72827874
73BRD40.72471051
74PRKCQ0.71183838
75TAOK10.70865227
76NME10.70598904
77FES0.68292934
78ADRBK10.68047513
79FER0.67992958
80STK380.67418123
81KSR20.66099300
82EPHB10.65751837
83MAP3K80.65508698
84PRKG20.63635490
85CDK80.62425486
86MAP3K30.61303606
87CAMK1D0.60270175
88SGK20.59020022
89LMTK20.58397606
90STK110.58215290
91MAPK70.58161430
92MAP3K120.56605065
93TNIK0.56447599
94MST40.55713571
95GRK70.55636507
96ZAK0.55354967
97ERBB30.54369677
98TESK20.53938866
99STK40.53833817
100RPS6KA60.53260290
101MAP2K60.53070303
102NLK0.52805016
103EPHA30.52470470
104DAPK20.51607359
105MARK30.51502473
106RPS6KA20.47269589
107MYLK0.45908215
108CAMK1G0.45140583
109AKT30.45078510
110RPS6KC10.44744865
111RPS6KL10.44744865
112ABL10.44187761
113ADRBK20.43641388
114PDPK10.42500551
115RET0.41866379
116EIF2AK20.41256707
117ATR0.41253790
118CDK60.40595321
119IRAK10.39437663
120MAP2K10.39354607
121FYN0.37859002
122STK30.37300070
123PRKAA20.36351112
124EGFR0.36083522
125MAPKAPK20.35238972
126MARK20.34789861
127PDK10.34553578
128MAP3K40.33987931
129MAPK30.33834435
130PRKD20.33589023
131MAP3K10.33541587
132ALK0.32428888
133ERBB20.32201768
134RAF10.30123489
135SGK30.29223117
136ACVR1B0.28822871
137ERN10.27814954

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.82471234
2Mineral absorption_Homo sapiens_hsa049782.35374428
3Osteoclast differentiation_Homo sapiens_hsa043802.26789729
4Hematopoietic cell lineage_Homo sapiens_hsa046402.15128204
5Primary immunodeficiency_Homo sapiens_hsa053402.07864820
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.06996762
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.03808382
8Primary bile acid biosynthesis_Homo sapiens_hsa001201.99853190
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.99507343
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.98600060
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.91050266
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.88706531
13Measles_Homo sapiens_hsa051621.87815950
14Other glycan degradation_Homo sapiens_hsa005111.76602662
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72193992
16Type I diabetes mellitus_Homo sapiens_hsa049401.71563604
17B cell receptor signaling pathway_Homo sapiens_hsa046621.70274028
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62842704
19Tuberculosis_Homo sapiens_hsa051521.60475125
20Toxoplasmosis_Homo sapiens_hsa051451.60414403
21Pertussis_Homo sapiens_hsa051331.57804427
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.55445842
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.54930899
24Staphylococcus aureus infection_Homo sapiens_hsa051501.52614931
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52173432
26* Influenza A_Homo sapiens_hsa051641.48048564
27Renin-angiotensin system_Homo sapiens_hsa046141.47990928
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.45250231
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45171787
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.44719664
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39386531
32Platelet activation_Homo sapiens_hsa046111.37563898
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34085983
34Salmonella infection_Homo sapiens_hsa051321.32492726
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30489243
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.29124117
37Graft-versus-host disease_Homo sapiens_hsa053321.27765633
38Chemokine signaling pathway_Homo sapiens_hsa040621.25764195
39* Herpes simplex infection_Homo sapiens_hsa051681.23638925
40Shigellosis_Homo sapiens_hsa051311.23200711
41TNF signaling pathway_Homo sapiens_hsa046681.20373692
42Ether lipid metabolism_Homo sapiens_hsa005651.19553065
43Hepatitis B_Homo sapiens_hsa051611.19204987
44Acute myeloid leukemia_Homo sapiens_hsa052211.18780375
45Chronic myeloid leukemia_Homo sapiens_hsa052201.18319889
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.17960614
47Apoptosis_Homo sapiens_hsa042101.17688425
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17438549
49T cell receptor signaling pathway_Homo sapiens_hsa046601.16324325
50Pancreatic cancer_Homo sapiens_hsa052121.13610328
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.11523093
52* Hepatitis C_Homo sapiens_hsa051601.11424895
53Asthma_Homo sapiens_hsa053101.09886932
54Caffeine metabolism_Homo sapiens_hsa002321.05302834
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03994896
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99697897
57Legionellosis_Homo sapiens_hsa051340.96285728
58Malaria_Homo sapiens_hsa051440.95330086
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90481012
60Sulfur metabolism_Homo sapiens_hsa009200.88963649
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88044164
62Thyroid cancer_Homo sapiens_hsa052160.84193499
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84130229
64Linoleic acid metabolism_Homo sapiens_hsa005910.83925010
65Sphingolipid metabolism_Homo sapiens_hsa006000.83087398
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82434364
67Antigen processing and presentation_Homo sapiens_hsa046120.81052825
68ABC transporters_Homo sapiens_hsa020100.80902203
69Allograft rejection_Homo sapiens_hsa053300.80775718
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80654321
71Prolactin signaling pathway_Homo sapiens_hsa049170.79258422
72African trypanosomiasis_Homo sapiens_hsa051430.77535080
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76268638
74Lysosome_Homo sapiens_hsa041420.74437224
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.73678486
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.72977547
77Non-small cell lung cancer_Homo sapiens_hsa052230.72933825
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70731347
79Small cell lung cancer_Homo sapiens_hsa052220.70602913
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67944764
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66107965
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.64600841
83FoxO signaling pathway_Homo sapiens_hsa040680.62894489
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61984136
85Glycerolipid metabolism_Homo sapiens_hsa005610.61724929
86Tryptophan metabolism_Homo sapiens_hsa003800.61318647
87Phagosome_Homo sapiens_hsa041450.60839533
88Bile secretion_Homo sapiens_hsa049760.60505140
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.60227860
90Notch signaling pathway_Homo sapiens_hsa043300.60101213
91Regulation of autophagy_Homo sapiens_hsa041400.59931946
92Phototransduction_Homo sapiens_hsa047440.59904524
93Olfactory transduction_Homo sapiens_hsa047400.59888881
94Insulin resistance_Homo sapiens_hsa049310.59131207
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58351371
96Arachidonic acid metabolism_Homo sapiens_hsa005900.57606017
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55972828
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55943197
99Viral myocarditis_Homo sapiens_hsa054160.55598075
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.55348585
101Colorectal cancer_Homo sapiens_hsa052100.55056862
102Butanoate metabolism_Homo sapiens_hsa006500.54834541
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.54224452
104Fatty acid biosynthesis_Homo sapiens_hsa000610.53339944
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52397875
106Rheumatoid arthritis_Homo sapiens_hsa053230.51795803
107Retinol metabolism_Homo sapiens_hsa008300.51573336
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50605566
109Type II diabetes mellitus_Homo sapiens_hsa049300.48592823
110mTOR signaling pathway_Homo sapiens_hsa041500.48281282
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47414413
112HIF-1 signaling pathway_Homo sapiens_hsa040660.47071145
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.46884465
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45716741
115Autoimmune thyroid disease_Homo sapiens_hsa053200.44937253
116Choline metabolism in cancer_Homo sapiens_hsa052310.43844435
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43829802
118Nitrogen metabolism_Homo sapiens_hsa009100.43577820
119Salivary secretion_Homo sapiens_hsa049700.43405208
120Vitamin digestion and absorption_Homo sapiens_hsa049770.42779020
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42681115
122Ovarian steroidogenesis_Homo sapiens_hsa049130.41871884
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39289014
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38905118
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37760316
126Dorso-ventral axis formation_Homo sapiens_hsa043200.37179458
127HTLV-I infection_Homo sapiens_hsa051660.36942450
128Prostate cancer_Homo sapiens_hsa052150.36419423
129Pathways in cancer_Homo sapiens_hsa052000.36240638
130N-Glycan biosynthesis_Homo sapiens_hsa005100.35881901
131Viral carcinogenesis_Homo sapiens_hsa052030.35836488
132Adherens junction_Homo sapiens_hsa045200.34888707
133Endometrial cancer_Homo sapiens_hsa052130.34748065
134Fanconi anemia pathway_Homo sapiens_hsa034600.33359173

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