RNASET2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.86427342
2negative regulation of cell killing (GO:0031342)5.45242572
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.45242572
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.43479931
5positive regulation by symbiont of host defense response (GO:0052509)5.25776911
6modulation by symbiont of host defense response (GO:0052031)5.25776911
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.25776911
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.25776911
9positive regulation by organism of defense response of other organism involved in symbiotic interact5.25776911
10modulation by symbiont of host immune response (GO:0052553)5.25776911
11antigen processing and presentation of endogenous antigen (GO:0019883)5.05680008
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.85687409
13immunoglobulin mediated immune response (GO:0016064)4.75607891
14neutrophil activation involved in immune response (GO:0002283)4.72732487
15detection of other organism (GO:0098543)4.52072341
16response to peptidoglycan (GO:0032494)4.48031175
17detection of bacterium (GO:0016045)4.46390054
18macrophage activation involved in immune response (GO:0002281)4.44780326
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.40699479
20regulation of B cell receptor signaling pathway (GO:0050855)4.37570655
21regulation of gamma-delta T cell activation (GO:0046643)4.20359177
22negative regulation of interleukin-12 production (GO:0032695)4.15095070
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.93072369
24detection of external biotic stimulus (GO:0098581)3.90983759
25microglial cell activation (GO:0001774)3.79981583
26respiratory burst (GO:0045730)3.79891245
27regulation of interferon-beta biosynthetic process (GO:0045357)3.74680237
28response to host immune response (GO:0052572)3.69870201
29response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.69870201
30cellular extravasation (GO:0045123)3.68665152
31regulation of gamma-delta T cell differentiation (GO:0045586)3.65547536
32positive regulation of B cell differentiation (GO:0045579)3.65517923
33B cell mediated immunity (GO:0019724)3.65194789
34detection of molecule of bacterial origin (GO:0032490)3.63709937
35leukocyte aggregation (GO:0070486)3.60611203
36negative regulation of lymphocyte mediated immunity (GO:0002707)3.57399642
37positive thymic T cell selection (GO:0045059)3.57330459
38interferon-gamma-mediated signaling pathway (GO:0060333)3.54639667
39response to type I interferon (GO:0034340)3.54356270
40defense response to protozoan (GO:0042832)3.54224353
41B cell receptor signaling pathway (GO:0050853)3.52662780
42cellular response to type I interferon (GO:0071357)3.51877013
43type I interferon signaling pathway (GO:0060337)3.51877013
44regulation of mast cell degranulation (GO:0043304)3.50647206
45myeloid cell activation involved in immune response (GO:0002275)3.49729343
46response to muramyl dipeptide (GO:0032495)3.47475830
47neutrophil activation (GO:0042119)3.46521002
48regulation of dendritic cell antigen processing and presentation (GO:0002604)3.46033179
49response to protozoan (GO:0001562)3.42083769
50detection of biotic stimulus (GO:0009595)3.41076943
51response to host defenses (GO:0052200)3.38998710
52response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.38998710
53response to host (GO:0075136)3.38998710
54regulation of antigen processing and presentation (GO:0002577)3.33279407
55negative thymic T cell selection (GO:0045060)3.33267213
56macrophage activation (GO:0042116)3.33227953
57negative regulation of leukocyte mediated immunity (GO:0002704)3.31700747
58regulation of myeloid leukocyte mediated immunity (GO:0002886)3.30872395
59regulation of B cell differentiation (GO:0045577)3.30677380
60positive regulation of antigen processing and presentation (GO:0002579)3.29762274
61granulocyte activation (GO:0036230)3.28286062
62negative regulation of T cell mediated immunity (GO:0002710)3.26186201
63T-helper 1 type immune response (GO:0042088)3.24977578
64positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.21510730
65regulation of mast cell activation involved in immune response (GO:0033006)3.20684792
66regulation of T cell tolerance induction (GO:0002664)3.20088902
67negative T cell selection (GO:0043383)3.19066807
68response to interleukin-15 (GO:0070672)3.18813325
69positive regulation of mast cell activation (GO:0033005)3.15573349
70regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.15399657
71germinal center formation (GO:0002467)3.11374505
72positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.10798872
73T cell migration (GO:0072678)3.07666739
74regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.07508286
75regulation of tolerance induction (GO:0002643)3.05801191
76negative regulation of erythrocyte differentiation (GO:0045647)3.04381524
77regulation of leukocyte degranulation (GO:0043300)3.03843203
78neutrophil mediated immunity (GO:0002446)3.03274170
79negative regulation of cytokine production involved in immune response (GO:0002719)3.02348881
80myeloid dendritic cell activation (GO:0001773)3.01927553
81regulation of mast cell activation (GO:0033003)3.00775057
82positive regulation of interferon-alpha production (GO:0032727)2.93888987
83negative regulation of innate immune response (GO:0045824)2.93011956
84regulation of alpha-beta T cell proliferation (GO:0046640)2.92428026
85myeloid dendritic cell differentiation (GO:0043011)2.91671458
86regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.91578190
87T cell selection (GO:0045058)2.91455572
88NIK/NF-kappaB signaling (GO:0038061)2.91247565
89positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.90959945
90lipopolysaccharide-mediated signaling pathway (GO:0031663)2.90131368
91negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.88996969
92regulation of interferon-alpha production (GO:0032647)2.87224653
93regulation of T-helper 2 cell differentiation (GO:0045628)2.86999962
94positive T cell selection (GO:0043368)2.86098998
95leukocyte degranulation (GO:0043299)2.84458828
96tolerance induction (GO:0002507)2.83876886
97negative regulation of phagocytosis (GO:0050765)2.83224792
98regulation of T cell mediated cytotoxicity (GO:0001914)2.82119645
99thymic T cell selection (GO:0045061)2.81956083
100positive regulation of mast cell activation involved in immune response (GO:0033008)2.81759042

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.96696496
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.24089493
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.65739466
4VDR_21846776_ChIP-Seq_THP-1_Human3.28348274
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.27301631
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.12933894
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.98953240
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.82879709
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.80330326
10VDR_24763502_ChIP-Seq_THP-1_Human2.74021755
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.66061088
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.64988353
13MYC_22102868_ChIP-Seq_BL_Human2.58105865
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.53542649
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.53398376
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47468321
17SPI1_23547873_ChIP-Seq_NB4_Human2.43127374
18* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.42105120
19SCL_19346495_ChIP-Seq_HPC-7_Human2.38378967
20MAF_26560356_Chip-Seq_TH1_Human2.33133969
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.31560998
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.30793203
23RUNX_20019798_ChIP-Seq_JUKART_Human2.27356741
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.27164343
25SPI1_23127762_ChIP-Seq_K562_Human2.26954542
26MYB_26560356_Chip-Seq_TH2_Human2.17262319
27BRD4_27068464_Chip-Seq_AML-cells_Mouse2.05842861
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.05171077
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.05064916
30* UTX_26944678_Chip-Seq_JUKART_Human2.04438579
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.03755443
32KDM2B_26808549_Chip-Seq_SUP-B15_Human2.03710605
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.01159534
34TCF7_22412390_ChIP-Seq_EML_Mouse1.89582236
35MYB_26560356_Chip-Seq_TH1_Human1.88849894
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.84481384
37MAF_26560356_Chip-Seq_TH2_Human1.82195007
38* LXR_22292898_ChIP-Seq_THP-1_Human1.79174514
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78592653
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.75662048
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.71826651
42KDM2B_26808549_Chip-Seq_DND41_Human1.70529727
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67989059
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67771465
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63537993
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62798722
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.60975887
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56680483
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.52667641
50VDR_24787735_ChIP-Seq_THP-1_Human1.51942453
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50813476
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48432476
53* GATA3_27048872_Chip-Seq_THYMUS_Human1.47326144
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47208021
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.44647776
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.43452708
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42947469
58BCL6_27268052_Chip-Seq_Bcells_Human1.41026469
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40862518
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40672749
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39540142
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36364820
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.35756726
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35727056
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34975593
66BCOR_27268052_Chip-Seq_Bcells_Human1.28655478
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.25591897
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25225114
69SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24991720
70PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23719309
71GATA1_19941826_ChIP-Seq_K562_Human1.21366687
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20532371
73ELF1_20517297_ChIP-Seq_JURKAT_Human1.20010049
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16907055
75* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16367279
76GATA1_22025678_ChIP-Seq_K562_Human1.15027426
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14930221
78ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14798251
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13671496
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12453086
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12283739
82PU_27001747_Chip-Seq_BMDM_Mouse1.11981792
83* GATA3_26560356_Chip-Seq_TH2_Human1.10696650
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08575039
85KDM2B_26808549_Chip-Seq_JURKAT_Human1.06567195
86* NCOR1_26117541_ChIP-Seq_K562_Human1.06256218
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03850892
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03716402
89P68_20966046_ChIP-Seq_HELA_Human1.01850707
90CIITA_25753668_ChIP-Seq_RAJI_Human0.98645484
91CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98025192
92SA1_27219007_Chip-Seq_ERYTHROID_Human0.97054304
93RACK7_27058665_Chip-Seq_MCF-7_Human0.95633033
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95515502
95NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95483400
96SPI1_20517297_ChIP-Seq_HL60_Human0.95429303
97* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94690438
98PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94637883
99STAT1_20625510_ChIP-Seq_HELA_Human0.94527426
100CTCF_26484167_Chip-Seq_Bcells_Mouse0.91433317

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.94273744
2MP0001835_abnormal_antigen_presentation3.81414624
3MP0003724_increased_susceptibility_to3.77851887
4MP0003303_peritoneal_inflammation3.76717829
5MP0005671_abnormal_response_to3.27511800
6MP0000685_abnormal_immune_system3.11539090
7MP0002419_abnormal_innate_immunity3.03330569
8MP0001800_abnormal_humoral_immune3.02386114
9MP0005387_immune_system_phenotype2.99721307
10MP0001790_abnormal_immune_system2.99721307
11MP0005025_abnormal_response_to2.95334640
12MP0009785_altered_susceptibility_to2.87114842
13MP0005000_abnormal_immune_tolerance2.85967476
14MP0002723_abnormal_immune_serum2.65950081
15MP0002452_abnormal_antigen_presenting2.62255019
16MP0006082_CNS_inflammation2.60276105
17MP0002148_abnormal_hypersensitivity_rea2.56940891
18MP0002420_abnormal_adaptive_immunity2.51170315
19MP0001819_abnormal_immune_cell2.49628923
20MP0005464_abnormal_platelet_physiology2.28308383
21MP0005058_abnormal_lysosome_morphology2.24130554
22MP0003300_gastrointestinal_ulcer2.23365831
23MP0003763_abnormal_thymus_physiology2.16749625
24MP0003172_abnormal_lysosome_physiology2.14580947
25MP0009278_abnormal_bone_marrow2.07622212
26MP0003191_abnormal_cellular_cholesterol2.06029526
27MP0002405_respiratory_system_inflammati1.99113607
28MP0008260_abnormal_autophagy1.95669772
29MP0002398_abnormal_bone_marrow1.95430808
30MP0001533_abnormal_skeleton_physiology1.94749915
31MP0000716_abnormal_immune_system1.94185235
32MP0010155_abnormal_intestine_physiology1.87432064
33MP0009333_abnormal_splenocyte_physiolog1.86891639
34MP0001845_abnormal_inflammatory_respons1.81394547
35MP0005451_abnormal_body_composition1.78161776
36MP0004947_skin_inflammation1.74545786
37MP0003183_abnormal_peptide_metabolism1.69115403
38MP0000689_abnormal_spleen_morphology1.65041077
39MP0008469_abnormal_protein_level1.59816483
40MP0003866_abnormal_defecation1.58123942
41MP0002429_abnormal_blood_cell1.57215725
42MP0005397_hematopoietic_system_phenotyp1.56152843
43MP0001545_abnormal_hematopoietic_system1.56152843
44MP0002722_abnormal_immune_system1.54845813
45MP0002396_abnormal_hematopoietic_system1.54019715
46MP0002132_abnormal_respiratory_system1.51938291
47MP0009764_decreased_sensitivity_to1.47801316
48MP0000465_gastrointestinal_hemorrhage1.46832780
49MP0003075_altered_response_to1.40562296
50MP0004510_myositis1.38559646
51MP0000858_altered_metastatic_potential1.31521447
52MP0005310_abnormal_salivary_gland1.31458718
53MP0002998_abnormal_bone_remodeling1.31017627
54MP0000703_abnormal_thymus_morphology1.29135971
55MP0003806_abnormal_nucleotide_metabolis1.24941889
56MP0001873_stomach_inflammation1.24652139
57MP0003828_pulmonary_edema1.22631244
58MP0001853_heart_inflammation1.17874015
59MP0009840_abnormal_foam_cell1.13983985
60MP0000604_amyloidosis1.12941148
61MP0004883_abnormal_blood_vessel1.10077986
62MP0002277_abnormal_respiratory_mucosa1.08759640
63MP0001851_eye_inflammation1.08382164
64MP0002166_altered_tumor_susceptibility1.06921693
65MP0005166_decreased_susceptibility_to1.05614767
66MP0001663_abnormal_digestive_system1.04650703
67MP0002138_abnormal_hepatobiliary_system1.03672122
68MP0003690_abnormal_glial_cell1.01630450
69MP0009763_increased_sensitivity_to0.99103193
70MP0000343_altered_response_to0.92573714
71MP0005164_abnormal_response_to0.90660119
72MP0004381_abnormal_hair_follicle0.89758189
73MP0002933_joint_inflammation0.89348854
74MP0004808_abnormal_hematopoietic_stem0.86219588
75MP0003656_abnormal_erythrocyte_physiolo0.85393070
76MP0008004_abnormal_stomach_pH0.84338976
77MP0000490_abnormal_crypts_of0.81806649
78MP0002139_abnormal_hepatobiliary_system0.80955280
79MP0005390_skeleton_phenotype0.76938462
80MP0005075_abnormal_melanosome_morpholog0.72678201
81MP0003448_altered_tumor_morphology0.72359074
82MP0000249_abnormal_blood_vessel0.70822647
83MP0005167_abnormal_blood-brain_barrier0.68082789
84MP0001986_abnormal_taste_sensitivity0.65469252
85MP0002006_tumorigenesis0.64131182
86MP0003795_abnormal_bone_structure0.63154899
87MP0009765_abnormal_xenobiotic_induced0.61048041
88MP0003045_fibrosis0.60892181
89MP0008874_decreased_physiological_sensi0.60283364
90MP0000609_abnormal_liver_physiology0.57916293
91MP0005381_digestive/alimentary_phenotyp0.56671046
92MP0005319_abnormal_enzyme/_coenzyme0.56496288
93MP0002019_abnormal_tumor_incidence0.56256561
94MP0005584_abnormal_enzyme/coenzyme_acti0.56219791
95MP0003453_abnormal_keratinocyte_physiol0.52476635
96MP0002136_abnormal_kidney_physiology0.50782328
97MP0002693_abnormal_pancreas_physiology0.50157420
98MP0000920_abnormal_myelination0.49759110
99MP0003329_amyloid_beta_deposits0.47905864
100MP0004858_abnormal_nervous_system0.47365785

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.31678941
2Recurrent bacterial skin infections (HP:0005406)5.66169564
3Recurrent abscess formation (HP:0002722)5.55741682
4Abnormality of macrophages (HP:0004311)5.12154580
5Myositis (HP:0100614)5.00713839
6Recurrent gram-negative bacterial infections (HP:0005420)4.65805794
7Orchitis (HP:0100796)4.53374238
8Mediastinal lymphadenopathy (HP:0100721)4.48858621
9Chronic obstructive pulmonary disease (HP:0006510)4.37718387
10Obstructive lung disease (HP:0006536)4.37718387
11Meningitis (HP:0001287)4.36987958
12Elevated erythrocyte sedimentation rate (HP:0003565)4.30059732
13Optic neuritis (HP:0100653)4.25368856
14Retrobulbar optic neuritis (HP:0100654)4.25368856
15Recurrent fungal infections (HP:0002841)4.22977961
16Stomatitis (HP:0010280)4.18352373
17Recurrent skin infections (HP:0001581)3.77569464
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.63473000
19Cellulitis (HP:0100658)3.62360908
20Vasculitis (HP:0002633)3.59725883
21Abnormality of liposaccharide metabolism (HP:0010968)3.48219609
22Abnormality of glycosphingolipid metabolism (HP:0004343)3.48219609
23Abnormality of glycolipid metabolism (HP:0010969)3.48219609
24Agammaglobulinemia (HP:0004432)3.44846436
25Gastrointestinal infarctions (HP:0005244)3.42031236
26Chronic mucocutaneous candidiasis (HP:0002728)3.31128846
27Recurrent cutaneous fungal infections (HP:0011370)3.31128846
28Panhypogammaglobulinemia (HP:0003139)3.30245359
29Recurrent viral infections (HP:0004429)3.26779737
30Increased IgE level (HP:0003212)3.26717585
31Urticaria (HP:0001025)3.23153103
32Encephalitis (HP:0002383)3.22959561
33Gingivitis (HP:0000230)3.18093831
34Pulmonary infiltrates (HP:0002113)3.14845693
35Systemic lupus erythematosus (HP:0002725)3.09264392
36Prolonged bleeding time (HP:0003010)2.98138413
37Keratoconjunctivitis sicca (HP:0001097)2.95644056
38Spontaneous hematomas (HP:0007420)2.94524562
39Increased cerebral lipofuscin (HP:0011813)2.93304871
40Colitis (HP:0002583)2.91324025
41Purpura (HP:0000979)2.90902751
42Hemoptysis (HP:0002105)2.89280912
43Inflammation of the large intestine (HP:0002037)2.86912222
44T lymphocytopenia (HP:0005403)2.86236203
45Chest pain (HP:0100749)2.81996831
46Gastrointestinal inflammation (HP:0004386)2.81190572
47Epistaxis (HP:0000421)2.73764065
48Osteomyelitis (HP:0002754)2.73247783
49Pustule (HP:0200039)2.72946734
50Gastrointestinal stroma tumor (HP:0100723)2.72697722
51Keratoconjunctivitis (HP:0001096)2.70528128
52Abnormality of T cell number (HP:0011839)2.69009197
53Abnormality of T cells (HP:0002843)2.67339634
54Granulocytopenia (HP:0001913)2.64169416
55Lymphopenia (HP:0001888)2.62143298
56Petechiae (HP:0000967)2.60644699
57Gingival bleeding (HP:0000225)2.57559831
58Dysostosis multiplex (HP:0000943)2.54668070
59Amyloidosis (HP:0011034)2.54545311
60Leukocytosis (HP:0001974)2.54502134
61Increased neuronal autofluorescent lipopigment (HP:0002074)2.54272135
62Pulmonary embolism (HP:0002204)2.52103041
63Loss of speech (HP:0002371)2.49294448
64Vacuolated lymphocytes (HP:0001922)2.48648736
65Abnormality of the pleura (HP:0002103)2.48076995
66Sepsis (HP:0100806)2.45472027
67Increased IgM level (HP:0003496)2.43413988
68Abnormality of T cell physiology (HP:0011840)2.43021811
69Recurrent pneumonia (HP:0006532)2.42683231
70IgM deficiency (HP:0002850)2.41773921
71Abnormality of cells of the lymphoid lineage (HP:0012140)2.41410118
72Increased serum ferritin (HP:0003281)2.36972818
73Recurrent sinusitis (HP:0011108)2.36966379
74Episodic fever (HP:0001954)2.36479464
75Arterial thrombosis (HP:0004420)2.34310528
76Hypochromic anemia (HP:0001931)2.29655231
77Gangrene (HP:0100758)2.26904900
78Restrictive lung disease (HP:0002091)2.25637747
79Recurrent bronchitis (HP:0002837)2.24910708
80Hepatosplenomegaly (HP:0001433)2.24877238
81Hypergammaglobulinemia (HP:0010702)2.21596409
82Anorexia (HP:0002039)2.20661500
83Autoimmune thrombocytopenia (HP:0001973)2.17791853
84Eosinophilia (HP:0001880)2.16530313
85Recurrent lower respiratory tract infections (HP:0002783)2.15777212
86Skin rash (HP:0000988)2.13665052
87Hypertensive crisis (HP:0100735)2.11088985
88Polygenic inheritance (HP:0010982)2.10936363
89Abnormality of iron homeostasis (HP:0011031)2.10735961
90Glomerulonephritis (HP:0000099)2.10411166
91Abnormality of B cell number (HP:0010975)2.08556677
92Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.08496920
93Autoimmune hemolytic anemia (HP:0001890)2.08117537
94Glomerulopathy (HP:0100820)2.03801928
95Skin ulcer (HP:0200042)2.03680463
96Papilloma (HP:0012740)2.03436202
97Verrucae (HP:0200043)2.03436202
98Abnormality of the prostate (HP:0008775)1.98907699
99Arthralgia (HP:0002829)1.98409638
100Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.98396109

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.30617108
2RIPK44.25103897
3ERN13.40598146
4BLK3.05872007
5IRAK42.75621135
6TYK22.60456014
7MAP2K32.54038952
8FES2.19692039
9MAP3K142.10068200
10PRPF4B2.08742021
11CSK2.07686284
12MAP3K112.02766349
13TBK12.02706008
14SYK1.95919708
15GRK61.92152230
16IKBKE1.90225653
17BTK1.89422639
18TNK21.87774029
19JAK31.87459718
20CSF1R1.85222889
21ZAP701.81690015
22TXK1.78406710
23TAOK31.74573732
24MAP3K131.74283129
25MAP3K31.64195734
26FGR1.61409877
27KIT1.59080372
28TAOK11.57253680
29HCK1.50552089
30LYN1.49764850
31TAOK21.42776848
32IKBKB1.34164959
33MATK1.27845159
34LCK1.25579252
35EPHB11.24984376
36MAP3K11.24811093
37JAK11.23233290
38SIK21.20210966
39JAK21.17159169
40ITK1.16525015
41SIK31.15084175
42BMPR21.11219723
43MARK31.10395311
44TRIB31.02258821
45FGFR41.01356176
46TESK20.98599067
47PDK10.95977557
48MARK20.95523557
49TEC0.90970350
50TGFBR20.90461863
51IRAK30.84513540
52SMG10.84205179
53CDC42BPA0.83180789
54PDPK10.82408196
55PRKD20.80313565
56NME20.75144222
57SIK10.74175992
58IRAK10.70489134
59FGFR30.69955242
60PIM10.69346183
61GRK70.66889047
62MAPK120.66766179
63PRKCQ0.65862146
64STK100.63257616
65KSR20.61838649
66HIPK20.59195108
67PTK60.58977474
68MAP3K70.57893643
69DYRK1B0.57328727
70FYN0.55795843
71RPS6KL10.54330234
72RPS6KC10.54330234
73CDK190.50990592
74EPHA30.50977543
75LRRK20.50696178
76MAP3K50.49412553
77RPS6KA60.47486981
78KDR0.47032818
79YES10.46501239
80IRAK20.45296111
81MAP2K60.44280336
82PIK3CG0.43622023
83MAPKAPK20.43398825
84TLK10.43046259
85CAMKK10.41993709
86MAPK110.41380879
87MAPK70.41336236
88BCKDK0.40496071
89CDK40.39344203
90CHUK0.36544170
91RIPK10.35315858
92MAP2K20.33354196
93RET0.31458101
94PRKD10.30116790
95CDK120.29943628
96PIM20.29114654
97PRKCD0.28402464
98ICK0.27198250
99MAPK40.26950838
100ABL10.26272081

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.39439547
2Staphylococcus aureus infection_Homo sapiens_hsa051503.34358300
3Graft-versus-host disease_Homo sapiens_hsa053323.19755293
4Leishmaniasis_Homo sapiens_hsa051403.16668876
5Autoimmune thyroid disease_Homo sapiens_hsa053203.11992670
6Asthma_Homo sapiens_hsa053102.81205581
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.71937796
8Osteoclast differentiation_Homo sapiens_hsa043802.70360005
9Primary immunodeficiency_Homo sapiens_hsa053402.67038891
10Type I diabetes mellitus_Homo sapiens_hsa049402.48522171
11Other glycan degradation_Homo sapiens_hsa005112.41620924
12B cell receptor signaling pathway_Homo sapiens_hsa046622.31605795
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.31098754
14Antigen processing and presentation_Homo sapiens_hsa046122.19884596
15Tuberculosis_Homo sapiens_hsa051522.08171788
16Toll-like receptor signaling pathway_Homo sapiens_hsa046202.03718321
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.89441089
18Viral myocarditis_Homo sapiens_hsa054161.87176161
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.82437378
20Hematopoietic cell lineage_Homo sapiens_hsa046401.78569192
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.70327231
22Toxoplasmosis_Homo sapiens_hsa051451.66489192
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59490417
24Rheumatoid arthritis_Homo sapiens_hsa053231.59390678
25Influenza A_Homo sapiens_hsa051641.57731290
26Malaria_Homo sapiens_hsa051441.54516961
27Measles_Homo sapiens_hsa051621.52929473
28Herpes simplex infection_Homo sapiens_hsa051681.50689303
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43423288
30Acute myeloid leukemia_Homo sapiens_hsa052211.42720977
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37509047
32Phagosome_Homo sapiens_hsa041451.36643375
33T cell receptor signaling pathway_Homo sapiens_hsa046601.33912096
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28579500
35Legionellosis_Homo sapiens_hsa051341.27029297
36Chemokine signaling pathway_Homo sapiens_hsa040621.25836491
37Pertussis_Homo sapiens_hsa051331.24641236
38TNF signaling pathway_Homo sapiens_hsa046681.24635179
39Lysosome_Homo sapiens_hsa041421.23692172
40African trypanosomiasis_Homo sapiens_hsa051431.23377399
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13944683
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.10136928
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06473821
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.04508750
45Hepatitis C_Homo sapiens_hsa051601.03330910
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98428588
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.98126357
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95883189
49Hepatitis B_Homo sapiens_hsa051610.91364826
50Systemic lupus erythematosus_Homo sapiens_hsa053220.89910261
51Platelet activation_Homo sapiens_hsa046110.87757630
52Salmonella infection_Homo sapiens_hsa051320.86306044
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85087900
54Epstein-Barr virus infection_Homo sapiens_hsa051690.84541259
55Apoptosis_Homo sapiens_hsa042100.82149520
56Shigellosis_Homo sapiens_hsa051310.81825894
57Non-small cell lung cancer_Homo sapiens_hsa052230.80233838
58VEGF signaling pathway_Homo sapiens_hsa043700.71191467
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69557203
60Pancreatic cancer_Homo sapiens_hsa052120.62160622
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61936202
62HTLV-I infection_Homo sapiens_hsa051660.60666322
63Viral carcinogenesis_Homo sapiens_hsa052030.57791197
64Complement and coagulation cascades_Homo sapiens_hsa046100.57294065
65Chronic myeloid leukemia_Homo sapiens_hsa052200.55675034
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.55105336
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51717930
68Prolactin signaling pathway_Homo sapiens_hsa049170.51696475
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.50894393
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50450445
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49799956
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.48636974
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48618978
74Endocytosis_Homo sapiens_hsa041440.48114057
75HIF-1 signaling pathway_Homo sapiens_hsa040660.44611985
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38386438
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.38085879
78Renal cell carcinoma_Homo sapiens_hsa052110.37744120
79Galactose metabolism_Homo sapiens_hsa000520.37308908
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.36879244
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34444636
82Amoebiasis_Homo sapiens_hsa051460.34419788
83Notch signaling pathway_Homo sapiens_hsa043300.33933733
84Insulin resistance_Homo sapiens_hsa049310.30066171
85FoxO signaling pathway_Homo sapiens_hsa040680.29833002
86Choline metabolism in cancer_Homo sapiens_hsa052310.28257227
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27578325
88mTOR signaling pathway_Homo sapiens_hsa041500.27460139
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26982295
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24217087
91MAPK signaling pathway_Homo sapiens_hsa040100.24081279
92GnRH signaling pathway_Homo sapiens_hsa049120.23520304
93Prion diseases_Homo sapiens_hsa050200.20893190
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20406436
95Fructose and mannose metabolism_Homo sapiens_hsa000510.20128808
96Collecting duct acid secretion_Homo sapiens_hsa049660.18878926
97Bladder cancer_Homo sapiens_hsa052190.16093601
98Arachidonic acid metabolism_Homo sapiens_hsa005900.14705731
99Regulation of autophagy_Homo sapiens_hsa041400.13423286
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13360559

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