RND1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the Rho GTPase family. Members of this family regulate the organization of the actin cytoskeleton in response to extracellular growth factors. A similar protein in rat interacts with a microtubule regulator to control axon extension. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)8.29539986
2polyketide metabolic process (GO:0030638)8.29539986
3doxorubicin metabolic process (GO:0044598)8.29539986
4response to pheromone (GO:0019236)5.69620147
5detection of molecule of bacterial origin (GO:0032490)5.66941995
6tryptophan catabolic process (GO:0006569)5.33853586
7indole-containing compound catabolic process (GO:0042436)5.33853586
8indolalkylamine catabolic process (GO:0046218)5.33853586
9kynurenine metabolic process (GO:0070189)5.14276259
10regulation of chronic inflammatory response (GO:0002676)4.88562013
11branching involved in labyrinthine layer morphogenesis (GO:0060670)4.84444648
12aminoglycoside antibiotic metabolic process (GO:0030647)4.78820046
13regulation of somitogenesis (GO:0014807)4.48401384
14tryptophan metabolic process (GO:0006568)4.32336148
15regulation of vitamin D biosynthetic process (GO:0060556)4.14024433
16amine catabolic process (GO:0009310)4.11923461
17cellular biogenic amine catabolic process (GO:0042402)4.11923461
18auditory receptor cell stereocilium organization (GO:0060088)4.11411313
19negative regulation of amino acid transport (GO:0051956)4.07964537
20energy homeostasis (GO:0097009)4.06749092
21positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.06625841
22opioid receptor signaling pathway (GO:0038003)3.88059973
23positive regulation of cellular amide metabolic process (GO:0034250)3.87965707
24detection of external biotic stimulus (GO:0098581)3.81046157
25indolalkylamine metabolic process (GO:0006586)3.73470305
26regulation of T-helper 1 cell differentiation (GO:0045625)3.67941468
27cellular response to ATP (GO:0071318)3.63576963
28positive regulation of heat generation (GO:0031652)3.51320805
29regulation of fever generation (GO:0031620)3.50322098
30regulation of cytokine secretion involved in immune response (GO:0002739)3.48594972
31indole-containing compound metabolic process (GO:0042430)3.46196044
32vocalization behavior (GO:0071625)3.44097108
33aromatic amino acid family catabolic process (GO:0009074)3.43113738
34inner ear receptor stereocilium organization (GO:0060122)3.43011844
35positive regulation of cAMP-mediated signaling (GO:0043950)3.37816945
36detection of biotic stimulus (GO:0009595)3.34585173
37lateral ventricle development (GO:0021670)3.31086939
38sulfate transmembrane transport (GO:1902358)3.19311777
39regulation of vitamin metabolic process (GO:0030656)3.18892772
40cerebral cortex radially oriented cell migration (GO:0021799)3.13691538
41cellular anion homeostasis (GO:0030002)3.13322182
42neuromuscular process controlling posture (GO:0050884)3.11746990
43negative regulation of synaptic transmission, GABAergic (GO:0032229)3.11140914
44post-embryonic morphogenesis (GO:0009886)3.11037032
45synaptic vesicle docking involved in exocytosis (GO:0016081)3.09872620
46regulation of immunoglobulin secretion (GO:0051023)3.07969229
47positive regulation of defense response to virus by host (GO:0002230)3.06799374
48regulation of interferon-alpha production (GO:0032647)3.03011499
49gamma-aminobutyric acid transport (GO:0015812)3.02864949
50cellular response to nicotine (GO:0071316)3.02681953
51negative regulation of macroautophagy (GO:0016242)3.02013536
52regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.01030511
53ganglion development (GO:0061548)2.99784098
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.99182868
55regulation of glutamate secretion (GO:0014048)2.98286687
56negative regulation of mast cell activation (GO:0033004)2.96537840
57serotonin metabolic process (GO:0042428)2.85880989
58sulfate transport (GO:0008272)2.85158349
59regulation of interleukin-6 biosynthetic process (GO:0045408)2.84829592
60positive regulation of nitric oxide biosynthetic process (GO:0045429)2.84555762
61superoxide anion generation (GO:0042554)2.81306832
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.80352837
63response to peptidoglycan (GO:0032494)2.78774574
64positive regulation of chemokine biosynthetic process (GO:0045080)2.76334449
65G-protein coupled receptor internalization (GO:0002031)2.75278573
66modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.73727801
67positive regulation by organism of defense response of other organism involved in symbiotic interact2.73727801
68modulation by symbiont of host immune response (GO:0052553)2.73727801
69positive regulation by symbiont of host defense response (GO:0052509)2.73727801
70modulation by symbiont of host defense response (GO:0052031)2.73727801
71modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.73727801
72regulation of amino acid transport (GO:0051955)2.72807170
73regulation of heat generation (GO:0031650)2.72760214
74ionotropic glutamate receptor signaling pathway (GO:0035235)2.72261485
75NAD biosynthetic process (GO:0009435)2.71277842
76sulfation (GO:0051923)2.70761784
77cellular response to exogenous dsRNA (GO:0071360)2.69639263
78regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.68349889
79primary amino compound metabolic process (GO:1901160)2.67714280
80exogenous drug catabolic process (GO:0042738)2.67008748
81regulation of nitric oxide biosynthetic process (GO:0045428)2.66542788
82drinking behavior (GO:0042756)2.66087171
83response to amphetamine (GO:0001975)2.65475457
84macrophage activation (GO:0042116)2.65035546
85axon extension involved in axon guidance (GO:0048846)2.63788211
86neuron projection extension involved in neuron projection guidance (GO:1902284)2.63788211
87postsynaptic membrane organization (GO:0001941)2.62036660
88modulation by virus of host process (GO:0019054)2.61837930
89drug catabolic process (GO:0042737)2.60281886
90regulation of chemokine biosynthetic process (GO:0045073)2.58963869
91regulation of activation of Janus kinase activity (GO:0010533)2.57571282
92negative regulation of systemic arterial blood pressure (GO:0003085)2.57006637
93response to muramyl dipeptide (GO:0032495)2.56227195
94bicarbonate transport (GO:0015701)2.56182681
95positive regulation of CREB transcription factor activity (GO:0032793)2.53867503
96positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.53641265
97monocyte chemotaxis (GO:0002548)2.53562065
98regulation of T-helper cell differentiation (GO:0045622)2.52084639
99response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.50426601
100response to host immune response (GO:0052572)2.50426601
101negative regulation of lipid storage (GO:0010888)2.50244936
102positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.49104621
103positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.49041675
104serotonin receptor signaling pathway (GO:0007210)2.47909833
105regulation of heterotypic cell-cell adhesion (GO:0034114)2.47558950
106positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.47462828
107behavioral response to nicotine (GO:0035095)2.46750062
108microglial cell activation (GO:0001774)2.46680719
109benzene-containing compound metabolic process (GO:0042537)2.44865409
110cellular response to interferon-beta (GO:0035458)2.43533218
111positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.43284101
112response to manganese ion (GO:0010042)2.42896107
113regulation of dendritic cell antigen processing and presentation (GO:0002604)2.42582036
114hydrogen peroxide biosynthetic process (GO:0050665)2.40335722
115regulation of glutamate receptor signaling pathway (GO:1900449)2.40117189
116vasodilation (GO:0042311)2.39647949
117polyol transport (GO:0015791)2.39477944
118synaptic transmission, glutamatergic (GO:0035249)2.39131513
119positive regulation of uterine smooth muscle contraction (GO:0070474)2.39122568
120negative regulation of blood pressure (GO:0045776)2.38898648
121positive regulation of neurotransmitter secretion (GO:0001956)2.37975532
122cAMP catabolic process (GO:0006198)2.36747707
123response to type I interferon (GO:0034340)2.36572895
124positive regulation of fatty acid transport (GO:2000193)2.36261467
125positive regulation of icosanoid secretion (GO:0032305)2.35761966
126type I interferon signaling pathway (GO:0060337)2.34757176
127cellular response to type I interferon (GO:0071357)2.34757176
128glutamate receptor signaling pathway (GO:0007215)2.34721282
129regulation of sensory perception (GO:0051931)2.33990997
130regulation of sensory perception of pain (GO:0051930)2.33990997
131regulation of cellular extravasation (GO:0002691)2.33756064
132dendritic spine morphogenesis (GO:0060997)2.33499083
133negative regulation of telomere maintenance (GO:0032205)2.32543733
134synaptic transmission, cholinergic (GO:0007271)2.31703997
135response to auditory stimulus (GO:0010996)2.31425346
136modulation by symbiont of host cellular process (GO:0044068)2.31195391
137positive regulation of organic acid transport (GO:0032892)2.30720986
138trivalent inorganic anion homeostasis (GO:0072506)2.30689734
139phosphate ion homeostasis (GO:0055062)2.30689734
140regulation of interleukin-8 biosynthetic process (GO:0045414)2.30634333
141regulation of mononuclear cell migration (GO:0071675)2.30423448
142developmental pigmentation (GO:0048066)2.30416984
143epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.29809423
144regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.29707498
145regulation of cAMP-mediated signaling (GO:0043949)2.29670598
146positive regulation of prostaglandin secretion (GO:0032308)2.29662598
147regulation of synapse maturation (GO:0090128)2.28913431
148prepulse inhibition (GO:0060134)2.28907275
149water-soluble vitamin biosynthetic process (GO:0042364)2.28115125
150regulation of short-term neuronal synaptic plasticity (GO:0048172)2.28106147
151extracellular regulation of signal transduction (GO:1900115)2.28023978
152extracellular negative regulation of signal transduction (GO:1900116)2.28023978
153pyrimidine nucleobase catabolic process (GO:0006208)2.27227800
154regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.26473613
155negative regulation of stem cell proliferation (GO:2000647)2.25556415
156positive regulation of action potential (GO:0045760)2.24395269
157detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.23777353
158positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.23115302
159positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.22947095
160glycerophospholipid catabolic process (GO:0046475)2.22933043
161neuronal action potential (GO:0019228)2.22750303
162response to host (GO:0075136)2.22748675
163response to host defenses (GO:0052200)2.22748675
164response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.22748675
165positive regulation of amino acid transport (GO:0051957)2.22718070
166prostate gland growth (GO:0060736)2.22678262
167regulation of norepinephrine secretion (GO:0014061)2.22155959
168regulation of T-helper 1 type immune response (GO:0002825)2.21918005
169aromatic amino acid family metabolic process (GO:0009072)2.21747913
170neuron cell-cell adhesion (GO:0007158)2.20470598
171positive regulation of T-helper cell differentiation (GO:0045624)2.19594270
172adhesion of symbiont to host cell (GO:0044650)2.19513115
173virion attachment to host cell (GO:0019062)2.19513115
174cyclic nucleotide catabolic process (GO:0009214)2.19129395
175circadian sleep/wake cycle process (GO:0022410)2.18886807
176positive regulation of vascular permeability (GO:0043117)2.18859024
177positive regulation of NF-kappaB import into nucleus (GO:0042346)2.18760126
178auditory behavior (GO:0031223)2.18039397
179positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.17873786
180positive regulation of interleukin-1 beta secretion (GO:0050718)2.16306994
181startle response (GO:0001964)2.15474244
182positive regulation of protein sumoylation (GO:0033235)2.14887803
183positive regulation of interleukin-1 secretion (GO:0050716)2.14157944
184negative regulation of myoblast differentiation (GO:0045662)2.14011153
185regulation of prostaglandin secretion (GO:0032306)2.11965167
186G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.11726530
187negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.11649655
188sprouting angiogenesis (GO:0002040)2.11166894
189presynaptic membrane assembly (GO:0097105)2.11043684

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.82393203
2EZH2_22144423_ChIP-Seq_EOC_Human3.75660220
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.64910422
4ZNF274_21170338_ChIP-Seq_K562_Hela2.91254616
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.81101150
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.72766314
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49326322
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.43136593
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42946020
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.36168905
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31466374
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.28513458
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28062484
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24338813
15* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16646146
16* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16646146
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16549042
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.14721749
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11388327
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11185878
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01268874
22RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.89178536
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88278369
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84387702
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.83464443
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.82178173
27AR_21572438_ChIP-Seq_LNCaP_Human1.81818731
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.79557810
29PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.76363208
30TAF15_26573619_Chip-Seq_HEK293_Human1.74566380
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72812352
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72215551
33* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71651033
34P300_19829295_ChIP-Seq_ESCs_Human1.71646861
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70748467
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.67180550
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63276300
38IGF1R_20145208_ChIP-Seq_DFB_Human1.60768610
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59127370
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51569048
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.49894188
42DROSHA_22980978_ChIP-Seq_HELA_Human1.49829136
43* ESR1_21235772_ChIP-Seq_MCF-7_Human1.47569519
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46999458
45RNF2_27304074_Chip-Seq_NSC_Mouse1.46529681
46* REST_18959480_ChIP-ChIP_MESCs_Mouse1.45396493
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.44262062
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.44068795
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41205763
50E2F1_18555785_Chip-Seq_ESCs_Mouse1.40466665
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.40367601
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39883302
53SMAD4_21799915_ChIP-Seq_A2780_Human1.39769889
54TRIM28_21343339_ChIP-Seq_HEK293_Human1.39360942
55EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38577295
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.38156037
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.37524859
58TP53_18474530_ChIP-ChIP_U2OS_Human1.35822155
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.35403601
60* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35158472
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34286715
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32666466
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32500050
64VDR_22108803_ChIP-Seq_LS180_Human1.31618578
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31162970
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30718168
67REST_21632747_ChIP-Seq_MESCs_Mouse1.29235590
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29163409
69RXR_22108803_ChIP-Seq_LS180_Human1.28585549
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26352805
71ER_23166858_ChIP-Seq_MCF-7_Human1.26294631
72AR_25329375_ChIP-Seq_VCAP_Human1.26278186
73P53_22387025_ChIP-Seq_ESCs_Mouse1.25306826
74SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24853725
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24818081
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21573986
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21435668
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.21141360
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.20208899
80NMYC_18555785_Chip-Seq_ESCs_Mouse1.18985860
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.18363638
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17181422
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15207735
84JUN_21703547_ChIP-Seq_K562_Human1.14924691
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13800850
86ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13512520
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11059263
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10902440
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10546989
90EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10255329
91BCAT_22108803_ChIP-Seq_LS180_Human1.10070697
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.10006913
93RUNX1_27457419_Chip-Seq_LIVER_Mouse1.09970736
94OCT4_18555785_Chip-Seq_ESCs_Mouse1.09899528
95CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.09766499
96PU1_27457419_Chip-Seq_LIVER_Mouse1.09603018
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09233063
98TP53_16413492_ChIP-PET_HCT116_Human1.08336910
99P300_18555785_Chip-Seq_ESCs_Mouse1.08321459
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08220021
101CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07982182
102FOXA1_25329375_ChIP-Seq_VCAP_Human1.07637707
103FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07637707
104SOX2_18555785_Chip-Seq_ESCs_Mouse1.07575984
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07237544
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07237544
107RING1B_27294783_Chip-Seq_ESCs_Mouse1.06584332
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06009073
109ESR2_21235772_ChIP-Seq_MCF-7_Human1.05453961
110NANOG_19829295_ChIP-Seq_ESCs_Human1.05411569
111SOX2_19829295_ChIP-Seq_ESCs_Human1.05411569
112Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05400862
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04451034
114RUNX2_22187159_ChIP-Seq_PCA_Human1.04144880
115IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04004776
116CBP_20019798_ChIP-Seq_JUKART_Human1.04004776
117GATA3_21878914_ChIP-Seq_MCF-7_Human1.02862445
118ZFX_18555785_Chip-Seq_ESCs_Mouse1.02824184
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02506755
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02483120
121ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02247804
122* STAT3_23295773_ChIP-Seq_U87_Human1.01682705
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01121707
124KDM2B_26808549_Chip-Seq_REH_Human1.00867780
125TCF4_23295773_ChIP-Seq_U87_Human1.00655848
126NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00176668
127ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99006759
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95351994
129EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95075540
130IRF1_19129219_ChIP-ChIP_H3396_Human0.93782438
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93063739
132EWS_26573619_Chip-Seq_HEK293_Human0.91607773
133FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90809581
134IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89970532
135RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87999772

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.77457466
2MP0008004_abnormal_stomach_pH3.77392429
3MP0003195_calcinosis3.67755824
4MP0003724_increased_susceptibility_to3.60438979
5MP0000566_synostosis3.25116704
6MP0005645_abnormal_hypothalamus_physiol3.19871921
7MP0006292_abnormal_olfactory_placode3.09393798
8MP0003878_abnormal_ear_physiology3.00922867
9MP0005377_hearing/vestibular/ear_phenot3.00922867
10MP0003941_abnormal_skin_development2.99900898
11MP0001188_hyperpigmentation2.97139390
12MP0003880_abnormal_central_pattern2.87536748
13MP0009697_abnormal_copulation2.55519324
14MP0002277_abnormal_respiratory_mucosa2.52903568
15MP0005171_absent_coat_pigmentation2.50198813
16MP0003879_abnormal_hair_cell2.41140487
17MP0001501_abnormal_sleep_pattern2.26010963
18MP0006276_abnormal_autonomic_nervous2.23890382
19MP0002138_abnormal_hepatobiliary_system2.20979434
20MP0006082_CNS_inflammation2.15672066
21MP0005257_abnormal_intraocular_pressure2.13659444
22MP0001440_abnormal_grooming_behavior2.11413997
23MP0005423_abnormal_somatic_nervous2.09741944
24MP0005167_abnormal_blood-brain_barrier2.08473952
25MP0009046_muscle_twitch2.05224225
26MP0002653_abnormal_ependyma_morphology2.03313048
27MP0004859_abnormal_synaptic_plasticity2.02818553
28MP0002736_abnormal_nociception_after1.93353432
29MP0001968_abnormal_touch/_nociception1.90927534
30MP0003303_peritoneal_inflammation1.90884135
31MP0004742_abnormal_vestibular_system1.88974030
32MP0002735_abnormal_chemical_nociception1.86286112
33MP0008875_abnormal_xenobiotic_pharmacok1.86208035
34MP0002102_abnormal_ear_morphology1.85268923
35MP0001486_abnormal_startle_reflex1.83818839
36MP0005646_abnormal_pituitary_gland1.83165071
37MP0003646_muscle_fatigue1.71838609
38MP0009840_abnormal_foam_cell1.59564691
39MP0009745_abnormal_behavioral_response1.58245440
40MP0002572_abnormal_emotion/affect_behav1.55188820
41MP0009764_decreased_sensitivity_to1.45665313
42MP0002332_abnormal_exercise_endurance1.45175382
43MP0004510_myositis1.44308423
44MP0002254_reproductive_system_inflammat1.37675653
45MP0002733_abnormal_thermal_nociception1.37651902
46MP0009785_altered_susceptibility_to1.35583646
47MP0001502_abnormal_circadian_rhythm1.34926257
48MP0004043_abnormal_pH_regulation1.33137588
49MP0003635_abnormal_synaptic_transmissio1.31360116
50MP0005551_abnormal_eye_electrophysiolog1.31110988
51MP0008872_abnormal_physiological_respon1.28553444
52MP0010386_abnormal_urinary_bladder1.27575864
53MP0005671_abnormal_response_to1.27357669
54MP0002064_seizures1.26758560
55MP0002837_dystrophic_cardiac_calcinosis1.25998129
56MP0004142_abnormal_muscle_tone1.25920235
57MP0003075_altered_response_to1.25663435
58MP0002148_abnormal_hypersensitivity_rea1.24009821
59MP0002557_abnormal_social/conspecific_i1.22554953
60MP0002063_abnormal_learning/memory/cond1.21348856
61MP0003828_pulmonary_edema1.17596334
62MP0000678_abnormal_parathyroid_gland1.17384855
63MP0001919_abnormal_reproductive_system1.16522883
64MP0001879_abnormal_lymphatic_vessel1.16030372
65MP0004885_abnormal_endolymph1.14988556
66MP0005365_abnormal_bile_salt1.13721089
67MP0005000_abnormal_immune_tolerance1.13380686
68MP0005390_skeleton_phenotype1.13322546
69MP0003045_fibrosis1.10766679
70MP0000015_abnormal_ear_pigmentation1.10694299
71MP0002067_abnormal_sensory_capabilities1.09861088
72MP0003690_abnormal_glial_cell1.08456513
73MP0001851_eye_inflammation1.07624370
74MP0004133_heterotaxia1.07259402
75MP0005535_abnormal_body_temperature1.07071490
76MP0001533_abnormal_skeleton_physiology1.06809791
77MP0004270_analgesia1.05168508
78MP0000026_abnormal_inner_ear1.04326555
79MP0002998_abnormal_bone_remodeling1.03676235
80MP0005448_abnormal_energy_balance1.03344943
81MP0002734_abnormal_mechanical_nocicepti1.03179978
82MP0003868_abnormal_feces_composition1.02355626
83MP0002419_abnormal_innate_immunity1.02092678
84MP0000681_abnormal_thyroid_gland1.01093425
85MP0005508_abnormal_skeleton_morphology1.00510498
86MP0008877_abnormal_DNA_methylation0.99287437
87MP0004782_abnormal_surfactant_physiolog0.99120378
88MP0005410_abnormal_fertilization0.98511399
89MP0005084_abnormal_gallbladder_morpholo0.98030903
90MP0003633_abnormal_nervous_system0.96707060
91MP0001986_abnormal_taste_sensitivity0.96620448
92MP0005025_abnormal_response_to0.95679348
93MP0004883_abnormal_blood_vessel0.95494837
94MP0010368_abnormal_lymphatic_system0.94636971
95MP0001963_abnormal_hearing_physiology0.91659204
96MP0005197_abnormal_uvea_morphology0.91360970
97MP0001905_abnormal_dopamine_level0.91086116
98MP0000778_abnormal_nervous_system0.90369508
99MP0001542_abnormal_bone_strength0.90334907
100MP0005595_abnormal_vascular_smooth0.89703233
101MP0005085_abnormal_gallbladder_physiolo0.89474222
102MP0003279_aneurysm0.88829125
103MP0001800_abnormal_humoral_immune0.88454084
104MP0003136_yellow_coat_color0.88428212
105MP0002723_abnormal_immune_serum0.87996919
106MP0008469_abnormal_protein_level0.87910860
107MP0005164_abnormal_response_to0.87534893
108MP0001970_abnormal_pain_threshold0.85901922
109MP0000049_abnormal_middle_ear0.85708209
110MP0002249_abnormal_larynx_morphology0.85695719
111MP0001764_abnormal_homeostasis0.84427530
112MP0002184_abnormal_innervation0.82638573
113MP0001663_abnormal_digestive_system0.82184848
114MP0003283_abnormal_digestive_organ0.80409152
115MP0000767_abnormal_smooth_muscle0.80331754
116MP0003091_abnormal_cell_migration0.79886045
117MP0009278_abnormal_bone_marrow0.79299499
118MP0002272_abnormal_nervous_system0.79237834
119MP0002638_abnormal_pupillary_reflex0.78328743
120MP0000604_amyloidosis0.77946345
121MP0002452_abnormal_antigen_presenting0.75590970
122MP0003436_decreased_susceptibility_to0.75333452
123MP0000631_abnormal_neuroendocrine_gland0.74936768
124MP0005195_abnormal_posterior_eye0.74788392
125MP0005647_abnormal_sex_gland0.74720103
126MP0002163_abnormal_gland_morphology0.74500038
127MP0001177_atelectasis0.74101153
128MP0001845_abnormal_inflammatory_respons0.73265136
129MP0002229_neurodegeneration0.73170621
130MP0001346_abnormal_lacrimal_gland0.72957413
131MP0000372_irregular_coat_pigmentation0.71673946
132MP0002693_abnormal_pancreas_physiology0.70800780
133MP0004381_abnormal_hair_follicle0.70668561
134MP0005266_abnormal_metabolism0.70561083
135MP0008260_abnormal_autophagy0.69649728
136MP0004858_abnormal_nervous_system0.67990773
137MP0002876_abnormal_thyroid_physiology0.67251253
138MP0004484_altered_response_of0.66840786
139MP0001485_abnormal_pinna_reflex0.66572706
140MP0005310_abnormal_salivary_gland0.66225639
141MP0005387_immune_system_phenotype0.64118234
142MP0001790_abnormal_immune_system0.64118234
143MP0005166_decreased_susceptibility_to0.64107282
144MP0008874_decreased_physiological_sensi0.63703757
145MP0003453_abnormal_keratinocyte_physiol0.61106503
146MP0004924_abnormal_behavior0.60747607
147MP0005386_behavior/neurological_phenoty0.60747607
148MP0000249_abnormal_blood_vessel0.60535841

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)5.49233262
2Unilateral renal agenesis (HP:0000122)4.65620767
3Anomalous pulmonary venous return (HP:0010772)4.60335860
4Alopecia of scalp (HP:0002293)4.44061345
5Abnormality of the pulmonary veins (HP:0011718)4.22800317
6Bilateral sensorineural hearing impairment (HP:0008619)3.73075715
7Focal motor seizures (HP:0011153)3.67093762
8Cheilitis (HP:0100825)3.48797217
9Absent/shortened dynein arms (HP:0200106)3.44403785
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.44403785
11Absent eyebrow (HP:0002223)3.43942887
12Febrile seizures (HP:0002373)3.42768951
13Follicular hyperkeratosis (HP:0007502)3.41286264
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.40341514
15Prostate neoplasm (HP:0100787)3.40224925
16Mutism (HP:0002300)3.28259864
17Stomatitis (HP:0010280)3.23519974
18Congenital stationary night blindness (HP:0007642)3.14247412
19Abnormality of dental color (HP:0011073)3.11112794
20Recurrent corneal erosions (HP:0000495)3.07914218
21Progressive cerebellar ataxia (HP:0002073)3.05326952
22Molar tooth sign on MRI (HP:0002419)3.01937935
23Abnormality of midbrain morphology (HP:0002418)3.01937935
24Pendular nystagmus (HP:0012043)3.00641109
25Abnormality of liposaccharide metabolism (HP:0010968)2.98899356
26Abnormality of glycosphingolipid metabolism (HP:0004343)2.98899356
27Abnormality of glycolipid metabolism (HP:0010969)2.98899356
28Submucous cleft hard palate (HP:0000176)2.96480589
29Chronic hepatic failure (HP:0100626)2.94700557
30Absent eyelashes (HP:0000561)2.90027735
31Pancreatic cysts (HP:0001737)2.86643098
32Conical tooth (HP:0000698)2.82755235
33Mesangial abnormality (HP:0001966)2.76930345
34Tetraparesis (HP:0002273)2.72319265
35Retrobulbar optic neuritis (HP:0100654)2.72244567
36Optic neuritis (HP:0100653)2.72244567
37Chromsome breakage (HP:0040012)2.66953917
38Hyperphosphatemia (HP:0002905)2.64278589
39Abnormality of incisor morphology (HP:0011063)2.62678488
40Septo-optic dysplasia (HP:0100842)2.62181574
41Type II lissencephaly (HP:0007260)2.61629283
42Alveolar cell carcinoma (HP:0006519)2.59735825
43Myelomeningocele (HP:0002475)2.58422802
44Congenital sensorineural hearing impairment (HP:0008527)2.54903755
45Abnormal ciliary motility (HP:0012262)2.51086137
46Osteomalacia (HP:0002749)2.47752629
47Nephronophthisis (HP:0000090)2.45966437
48Abnormality of the intervertebral disk (HP:0005108)2.45957714
49Duplicated collecting system (HP:0000081)2.45038389
50Limb dystonia (HP:0002451)2.44184750
51Abnormality of the renal collecting system (HP:0004742)2.43945764
52Abolished electroretinogram (ERG) (HP:0000550)2.43170206
53Stomach cancer (HP:0012126)2.39893119
54Orchitis (HP:0100796)2.39289064
55Abnormal respiratory motile cilium morphology (HP:0005938)2.36927258
56Abnormal respiratory epithelium morphology (HP:0012253)2.36927258
57Tubular atrophy (HP:0000092)2.32954477
58Inability to walk (HP:0002540)2.32591687
59Spastic tetraparesis (HP:0001285)2.31280197
60Patchy hypopigmentation of hair (HP:0011365)2.29571235
61Joint hemorrhage (HP:0005261)2.28463160
62Aplasia cutis congenita (HP:0001057)2.28074794
63Vacuolated lymphocytes (HP:0001922)2.27273001
64Large for gestational age (HP:0001520)2.25011766
65Keratoconjunctivitis (HP:0001096)2.22932317
66Focal seizures (HP:0007359)2.22506859
67Abnormality of the nasal septum (HP:0000419)2.22398423
68Genetic anticipation (HP:0003743)2.21749488
69Decreased central vision (HP:0007663)2.20376373
70Polyphagia (HP:0002591)2.19454854
71Agitation (HP:0000713)2.18705934
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18656678
73Abnormality of alanine metabolism (HP:0010916)2.18656678
74Hyperalaninemia (HP:0003348)2.18656678
75Hemiparesis (HP:0001269)2.14998121
76Severe muscular hypotonia (HP:0006829)2.13978099
77Atonic seizures (HP:0010819)2.13270322
78Epileptic encephalopathy (HP:0200134)2.11314686
79Urinary bladder sphincter dysfunction (HP:0002839)2.09766591
80White forelock (HP:0002211)2.08759979
81Abnormality of the renal medulla (HP:0100957)2.08024581
82Fair hair (HP:0002286)2.06979418
83Myokymia (HP:0002411)2.06635760
84Keratoconjunctivitis sicca (HP:0001097)2.05356071
85Generalized hypopigmentation of hair (HP:0011358)2.05287198
86Neoplasm of the tracheobronchial system (HP:0100552)2.05193950
87Disinhibition (HP:0000734)2.04468662
88Abnormality of B cell number (HP:0010975)2.02899678
89Autoimmune thrombocytopenia (HP:0001973)2.02654121
90Generalized aminoaciduria (HP:0002909)2.02233889
91Hyperventilation (HP:0002883)2.01964638
92Fetal akinesia sequence (HP:0001989)2.01211761
93Upper limb muscle weakness (HP:0003484)1.99696976
94Pulmonary artery stenosis (HP:0004415)1.99370909
95True hermaphroditism (HP:0010459)1.98163664
96Hydroxyprolinuria (HP:0003080)1.97889885
97Abnormality of proline metabolism (HP:0010907)1.97889885
98Xerostomia (HP:0000217)1.97792600
99Neoplasm of the lung (HP:0100526)1.97506271
1003-Methylglutaconic aciduria (HP:0003535)1.97226652
101Progressive inability to walk (HP:0002505)1.97169462
102Keratitis (HP:0000491)1.97145916
103Absent hair (HP:0002298)1.97130341
104Furrowed tongue (HP:0000221)1.96358192
105Cystic liver disease (HP:0006706)1.96012541
106Mitral stenosis (HP:0001718)1.95771143
107Inappropriate behavior (HP:0000719)1.95198687
108Medial flaring of the eyebrow (HP:0010747)1.94799901
109Hypergonadotropic hypogonadism (HP:0000815)1.94061809
110Recurrent abscess formation (HP:0002722)1.92380341
111Generalized tonic-clonic seizures (HP:0002069)1.91664980
112Dyskinesia (HP:0100660)1.90391895
113Abnormal drinking behavior (HP:0030082)1.89273754
114Polydipsia (HP:0001959)1.89273754
115Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89109169
116Respiratory distress (HP:0002098)1.88986994
117Optic nerve hypoplasia (HP:0000609)1.88973979
118Clubbing of toes (HP:0100760)1.88913398
119Action tremor (HP:0002345)1.88620928
120Corneal dystrophy (HP:0001131)1.87702391
121Abnormality of the renal cortex (HP:0011035)1.87440884
122Broad-based gait (HP:0002136)1.86807393
123Tachypnea (HP:0002789)1.86570293
124Abnormality of binocular vision (HP:0011514)1.86556066
125Diplopia (HP:0000651)1.86556066
126Systemic lupus erythematosus (HP:0002725)1.86385178
127Aortic valve stenosis (HP:0001650)1.85445371
128Dialeptic seizures (HP:0011146)1.85356096
129Attenuation of retinal blood vessels (HP:0007843)1.85323135
130Menorrhagia (HP:0000132)1.82355645
131Myositis (HP:0100614)1.81430719
132Chronic otitis media (HP:0000389)1.80665325
133Increased cerebral lipofuscin (HP:0011813)1.80661417
134Neurofibrillary tangles (HP:0002185)1.80640847
135Protruding tongue (HP:0010808)1.80570629
136Congenital, generalized hypertrichosis (HP:0004540)1.80148139
137Gait imbalance (HP:0002141)1.79748994
138Status epilepticus (HP:0002133)1.79558337
139Renal dysplasia (HP:0000110)1.78130661
140Ectopic kidney (HP:0000086)1.77899006
141Conjugated hyperbilirubinemia (HP:0002908)1.76408079
142Gaze-evoked nystagmus (HP:0000640)1.75951557
143Hemiplegia (HP:0002301)1.75175930
144Absent speech (HP:0001344)1.74272285
145Bile duct proliferation (HP:0001408)1.73531277
146Abnormal biliary tract physiology (HP:0012439)1.73531277
147Increased neuronal autofluorescent lipopigment (HP:0002074)1.73096784
148Global brain atrophy (HP:0002283)1.72925716
149Vascular calcification (HP:0004934)1.72646058
150Hyperglycinemia (HP:0002154)1.72517195
151Abnormality of the pons (HP:0007361)1.72437561
152Ventricular fibrillation (HP:0001663)1.71146101
153Concave nail (HP:0001598)1.70989328
154Congenital hepatic fibrosis (HP:0002612)1.70890474
155Bone pain (HP:0002653)1.70545501
156Porencephaly (HP:0002132)1.69922669
157Recurrent cutaneous fungal infections (HP:0011370)1.69470386
158Chronic mucocutaneous candidiasis (HP:0002728)1.69470386
159Recurrent pneumonia (HP:0006532)1.68914024
160Gangrene (HP:0100758)1.68384907
161Aplasia/Hypoplasia of the fovea (HP:0008060)1.67408369
162Hypoplasia of the fovea (HP:0007750)1.67408369
163Abnormal respiratory motile cilium physiology (HP:0012261)1.67024512
164Erythroderma (HP:0001019)1.65018750
165Mixed hearing impairment (HP:0000410)1.64569336
166Recurrent gram-negative bacterial infections (HP:0005420)1.63722869
167Oligohydramnios (HP:0001562)1.63077980
168Tetany (HP:0001281)1.62815447
169Pancreatic fibrosis (HP:0100732)1.62791523
170Vascular tortuosity (HP:0004948)1.61117360
171Ectropion (HP:0000656)1.60378736
172Abnormal hair whorl (HP:0010721)1.59631983
173Eczematoid dermatitis (HP:0000976)1.59522097
174Oligodontia (HP:0000677)1.59225780
175Cardiovascular calcification (HP:0011915)1.59118208
176Abnormality of the prostate (HP:0008775)1.58985484

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK35.63635452
2CASK3.39753922
3TIE13.24513419
4DAPK23.21239391
5SIK23.20644817
6MAP3K142.78867817
7ZAK2.71875828
8IRAK32.45688104
9ACVR1B2.42786117
10FRK2.42278951
11MAP3K122.26573116
12MAP2K72.26077113
13TNIK2.03224026
14NTRK31.96029202
15WNK31.92804574
16CDK81.88588383
17EIF2AK21.87916997
18MAP3K91.83127473
19SIK11.78090748
20EPHA21.77386223
21MARK31.72705167
22MARK11.69515508
23TLK11.61976249
24BLK1.55968511
25TXK1.55614290
26PINK11.54362991
27EPHA41.49852501
28MATK1.48625262
29BMPR21.47517345
30PNCK1.40750894
31RIPK41.38956707
32INSRR1.36422325
33EPHB21.31600903
34ADRBK21.30640959
35MAP4K21.28968369
36PAK61.28723695
37PRPF4B1.27866222
38IRAK41.27853312
39STK38L1.27003380
40LATS21.17558111
41TAOK31.17475228
42MAP3K111.14198470
43BRD41.09671968
44FES1.09552982
45ERBB31.08452028
46TYRO31.08169024
47WNK41.07679799
48GRK11.06825663
49TEC1.05399789
50MAP3K61.05310651
51PLK21.05186989
52RIPK11.02708778
53MAPK131.02372172
54PIM21.00793489
55SGK21.00034704
56TAOK20.98249042
57IKBKE0.98165661
58OXSR10.97312890
59IKBKB0.97312295
60NLK0.97026576
61AKT30.96269743
62YES10.91652236
63ADRBK10.88286404
64FER0.88075452
65MOS0.86024040
66GRK70.85361248
67DYRK30.84599378
68TGFBR20.84230306
69TGFBR10.82158351
70MAP2K40.82127503
71CDK30.81406523
72PKN10.80666083
73TBK10.79789785
74MAP2K60.78485148
75NTRK20.76277018
76BMPR1B0.73351977
77GRK50.73229881
78PRKCE0.72615903
79STK160.72141461
80TAOK10.71597683
81CDK50.70579533
82MAP3K50.70452352
83IRAK10.67901064
84TNK20.67373473
85MAP3K40.66217232
86CAMKK20.63596494
87MAPKAPK50.63572312
88MARK20.62699330
89PAK30.58904595
90SGK2230.57944022
91SGK4940.57944022
92MAPK70.57707948
93MAP3K130.56871987
94NEK60.56720870
95SGK10.56650429
96JAK10.55221773
97PRKCZ0.53827747
98PRKCQ0.53571220
99STK390.53064721
100VRK10.52429217
101CSNK1G20.51452215
102DYRK1A0.51363355
103CAMKK10.51177342
104ERBB40.50334416
105EPHA30.50153211
106PRKCI0.50138375
107MAPK150.49644619
108CDK120.48995513
109DDR20.48402240
110ABL20.48004964
111WEE10.46315636
112NUAK10.45748659
113MINK10.45465716
114PIM10.45421300
115RPS6KA50.45020780
116CHUK0.44577304
117STK380.43643122
118UHMK10.43348448
119CAMK40.43227434
120PRKCA0.42885481
121PRKCH0.42470866
122CAMK2A0.42003807
123TRPM70.41321925
124PRKACA0.41195736
125CCNB10.41096850
126HCK0.40935019
127IRAK20.40715916
128LATS10.40346331
129MKNK20.40114987
130PRKCG0.39660171
131MAP3K30.38773642
132MAPK40.37502107
133CAMK10.37132670
134CSK0.37050949
135CAMK2B0.36767906
136CSNK1A10.36095025
137PIK3CA0.35840835
138SGK30.35206482
139PRKG10.35003172
140DAPK30.34984750
141SYK0.34057883
142FGR0.33883274
143DYRK20.32837502
144BCKDK0.32477119
145STK110.32109101
146RPS6KA60.31931530
147LYN0.30998622
148PHKG20.30839436
149PHKG10.30839436
150CDC42BPA0.30031997

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.36620994
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.47953428
3Linoleic acid metabolism_Homo sapiens_hsa005912.39929879
4African trypanosomiasis_Homo sapiens_hsa051432.33622848
5Caffeine metabolism_Homo sapiens_hsa002322.30071474
6Tryptophan metabolism_Homo sapiens_hsa003802.07205615
7Malaria_Homo sapiens_hsa051442.06333183
8Rheumatoid arthritis_Homo sapiens_hsa053232.06079621
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.05436027
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.02032452
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.94005266
12TNF signaling pathway_Homo sapiens_hsa046681.87933109
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.87331076
14Staphylococcus aureus infection_Homo sapiens_hsa051501.78189444
15Butanoate metabolism_Homo sapiens_hsa006501.77749891
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.65386060
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.64631453
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.64497213
19Leishmaniasis_Homo sapiens_hsa051401.64025265
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.61928604
21Phototransduction_Homo sapiens_hsa047441.56801769
22Taste transduction_Homo sapiens_hsa047421.55814319
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54799496
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.53357754
25Morphine addiction_Homo sapiens_hsa050321.46526400
26Ether lipid metabolism_Homo sapiens_hsa005651.45465554
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39179323
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38882082
29Graft-versus-host disease_Homo sapiens_hsa053321.38238003
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.37527355
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.36908342
32Synaptic vesicle cycle_Homo sapiens_hsa047211.36456977
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.32882255
34Chemical carcinogenesis_Homo sapiens_hsa052041.30529711
35Osteoclast differentiation_Homo sapiens_hsa043801.29172823
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.28820859
37Serotonergic synapse_Homo sapiens_hsa047261.27979818
38Pertussis_Homo sapiens_hsa051331.24174053
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24171658
40GABAergic synapse_Homo sapiens_hsa047271.24089551
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21585516
42Glutamatergic synapse_Homo sapiens_hsa047241.19853139
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.19313188
44Phagosome_Homo sapiens_hsa041451.12958864
45Tuberculosis_Homo sapiens_hsa051521.11725965
46Calcium signaling pathway_Homo sapiens_hsa040201.10900254
47Ovarian steroidogenesis_Homo sapiens_hsa049131.10080252
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08773814
49* Axon guidance_Homo sapiens_hsa043601.07969808
50Hematopoietic cell lineage_Homo sapiens_hsa046401.07413122
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07407518
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07219720
53Circadian entrainment_Homo sapiens_hsa047131.05694930
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00406321
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99984185
56Sulfur metabolism_Homo sapiens_hsa009200.99557836
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98603499
58Arachidonic acid metabolism_Homo sapiens_hsa005900.97682055
59Selenocompound metabolism_Homo sapiens_hsa004500.97152028
60Measles_Homo sapiens_hsa051620.96520842
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93386413
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93011105
63Cocaine addiction_Homo sapiens_hsa050300.90433991
64ABC transporters_Homo sapiens_hsa020100.90170835
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88086866
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86377631
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86112004
68Oxidative phosphorylation_Homo sapiens_hsa001900.85698670
69Nitrogen metabolism_Homo sapiens_hsa009100.85058733
70Mineral absorption_Homo sapiens_hsa049780.84325686
71Lysosome_Homo sapiens_hsa041420.83576421
72Type I diabetes mellitus_Homo sapiens_hsa049400.83301163
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.83102206
74Melanoma_Homo sapiens_hsa052180.83101659
75Peroxisome_Homo sapiens_hsa041460.82608027
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82503211
77Autoimmune thyroid disease_Homo sapiens_hsa053200.81206602
78Salivary secretion_Homo sapiens_hsa049700.81022868
79Influenza A_Homo sapiens_hsa051640.78895623
80Sphingolipid metabolism_Homo sapiens_hsa006000.78485632
81Circadian rhythm_Homo sapiens_hsa047100.76726209
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74555868
83ErbB signaling pathway_Homo sapiens_hsa040120.74458975
84Amphetamine addiction_Homo sapiens_hsa050310.73214296
85Cholinergic synapse_Homo sapiens_hsa047250.71556154
86Complement and coagulation cascades_Homo sapiens_hsa046100.71409502
87Salmonella infection_Homo sapiens_hsa051320.70681248
88Histidine metabolism_Homo sapiens_hsa003400.70655299
89Dorso-ventral axis formation_Homo sapiens_hsa043200.70257273
90Collecting duct acid secretion_Homo sapiens_hsa049660.70252694
91Ras signaling pathway_Homo sapiens_hsa040140.69728479
92Asthma_Homo sapiens_hsa053100.69428938
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69323334
94Olfactory transduction_Homo sapiens_hsa047400.67839953
95Apoptosis_Homo sapiens_hsa042100.65818125
96Hepatitis C_Homo sapiens_hsa051600.65218936
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64939288
98Type II diabetes mellitus_Homo sapiens_hsa049300.64642396
99MAPK signaling pathway_Homo sapiens_hsa040100.64288119
100Bile secretion_Homo sapiens_hsa049760.63942144
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62957703
102Long-term depression_Homo sapiens_hsa047300.62886733
103Prion diseases_Homo sapiens_hsa050200.62507423
104Chemokine signaling pathway_Homo sapiens_hsa040620.62187490
105Toxoplasmosis_Homo sapiens_hsa051450.62006381
106Retinol metabolism_Homo sapiens_hsa008300.61667549
107Allograft rejection_Homo sapiens_hsa053300.60758330
108Herpes simplex infection_Homo sapiens_hsa051680.59018551
109Renin secretion_Homo sapiens_hsa049240.58412026
110Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57337241
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56854267
112Steroid biosynthesis_Homo sapiens_hsa001000.54509288
113Prolactin signaling pathway_Homo sapiens_hsa049170.53890791
114Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53678346
115cAMP signaling pathway_Homo sapiens_hsa040240.52665057
116Oxytocin signaling pathway_Homo sapiens_hsa049210.51572538
117Rap1 signaling pathway_Homo sapiens_hsa040150.51140252
118Hepatitis B_Homo sapiens_hsa051610.51023727
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50727371
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49306209
121Insulin secretion_Homo sapiens_hsa049110.49114525
122Regulation of autophagy_Homo sapiens_hsa041400.48761627
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.48757309
124Amoebiasis_Homo sapiens_hsa051460.48210662
125Dopaminergic synapse_Homo sapiens_hsa047280.47178922
126FoxO signaling pathway_Homo sapiens_hsa040680.46871543
127Fat digestion and absorption_Homo sapiens_hsa049750.45320850
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44595850
129Cardiac muscle contraction_Homo sapiens_hsa042600.43968507
130Legionellosis_Homo sapiens_hsa051340.42537674
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41591839
132Parkinsons disease_Homo sapiens_hsa050120.41042239
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40972834
134Basal transcription factors_Homo sapiens_hsa030220.40240547
135PPAR signaling pathway_Homo sapiens_hsa033200.39374454
136Notch signaling pathway_Homo sapiens_hsa043300.39231824
137Vitamin digestion and absorption_Homo sapiens_hsa049770.38600494
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.37728641

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