RND2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.31844736
2central nervous system myelination (GO:0022010)5.57424163
3axon ensheathment in central nervous system (GO:0032291)5.57424163
4presynaptic membrane assembly (GO:0097105)5.56746354
5postsynaptic membrane organization (GO:0001941)5.43957817
6synaptic vesicle maturation (GO:0016188)5.17727940
7regulation of short-term neuronal synaptic plasticity (GO:0048172)5.10692642
8L-amino acid import (GO:0043092)4.76478975
9synaptic vesicle exocytosis (GO:0016079)4.46025156
10neuron cell-cell adhesion (GO:0007158)4.43107910
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.37273204
12amino acid import (GO:0043090)4.34837406
13regulation of synaptic vesicle exocytosis (GO:2000300)4.33812173
14pyrimidine nucleobase catabolic process (GO:0006208)4.33338461
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.30067933
16gamma-aminobutyric acid transport (GO:0015812)4.26857796
17exploration behavior (GO:0035640)4.22965565
18neuronal action potential propagation (GO:0019227)4.12147114
19transmission of nerve impulse (GO:0019226)4.06913950
20neurotransmitter secretion (GO:0007269)4.05711901
21vocalization behavior (GO:0071625)4.04981475
22layer formation in cerebral cortex (GO:0021819)4.04668224
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.04527600
24glutamate secretion (GO:0014047)3.99240661
25regulation of neuronal synaptic plasticity (GO:0048168)3.98389164
26neuronal ion channel clustering (GO:0045161)3.95541702
27neuromuscular process controlling posture (GO:0050884)3.88635357
28dendritic spine morphogenesis (GO:0060997)3.87981916
29behavioral response to nicotine (GO:0035095)3.76369005
30regulation of synaptic vesicle transport (GO:1902803)3.75068823
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.70127456
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.69862854
33regulation of glutamate receptor signaling pathway (GO:1900449)3.69309910
34glycine transport (GO:0015816)3.66472377
35neuron recognition (GO:0008038)3.64038746
36neuromuscular process controlling balance (GO:0050885)3.52539561
37myelination (GO:0042552)3.49717715
38axonal fasciculation (GO:0007413)3.48866565
39regulation of synapse structural plasticity (GO:0051823)3.48088639
40synaptic vesicle docking involved in exocytosis (GO:0016081)3.45982427
41neurotransmitter transport (GO:0006836)3.43690606
42mating behavior (GO:0007617)3.43650090
43ensheathment of neurons (GO:0007272)3.42757333
44axon ensheathment (GO:0008366)3.42757333
45protein localization to synapse (GO:0035418)3.42366812
46dendrite morphogenesis (GO:0048813)3.42025998
47prepulse inhibition (GO:0060134)3.37516257
48positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.36184660
49sodium ion export (GO:0071436)3.35664327
50adult walking behavior (GO:0007628)3.30936789
51synaptic transmission, glutamatergic (GO:0035249)3.30711958
52neuron-neuron synaptic transmission (GO:0007270)3.29340894
53auditory behavior (GO:0031223)3.27774486
54C4-dicarboxylate transport (GO:0015740)3.27159773
55negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.26888078
56nucleobase catabolic process (GO:0046113)3.26461632
57positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.25738342
58cellular potassium ion homeostasis (GO:0030007)3.25003004
59regulation of neurotransmitter levels (GO:0001505)3.20449706
60acidic amino acid transport (GO:0015800)3.19357163
61long-term synaptic potentiation (GO:0060291)3.17362220
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.14424132
63glutamate receptor signaling pathway (GO:0007215)3.11701087
64cell migration in hindbrain (GO:0021535)3.11110288
65positive regulation of synaptic transmission, GABAergic (GO:0032230)3.09048261
66membrane hyperpolarization (GO:0060081)3.07922525
67behavioral response to cocaine (GO:0048148)3.07387230
68L-glutamate transport (GO:0015813)3.06999857
69cerebellar granule cell differentiation (GO:0021707)3.06727212
70neurotransmitter uptake (GO:0001504)3.06158531
71regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.06143911
72establishment of protein localization to mitochondrial membrane (GO:0090151)3.05612677
73neurotransmitter-gated ion channel clustering (GO:0072578)3.05611316
74spinal cord development (GO:0021510)3.04121565
75response to auditory stimulus (GO:0010996)3.03446752
76nonmotile primary cilium assembly (GO:0035058)3.03427323
77regulation of synaptic plasticity (GO:0048167)3.01205104
78membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.00236878
79long-term memory (GO:0007616)2.97632929
80negative regulation of glial cell differentiation (GO:0045686)2.96568626
81neuromuscular process (GO:0050905)2.96136117
82establishment of mitochondrion localization (GO:0051654)2.96000569
83cell proliferation in forebrain (GO:0021846)2.93069033
84regulation of posttranscriptional gene silencing (GO:0060147)2.91697865
85regulation of gene silencing by miRNA (GO:0060964)2.91697865
86regulation of gene silencing by RNA (GO:0060966)2.91697865
87negative regulation of astrocyte differentiation (GO:0048712)2.91668648
88chaperone-mediated protein transport (GO:0072321)2.90931963
89cranial nerve development (GO:0021545)2.90736508
90negative regulation of neurotransmitter transport (GO:0051589)2.86745327
91outer ear morphogenesis (GO:0042473)2.86132206
92regulation of dendritic spine morphogenesis (GO:0061001)2.85677588
93response to methylmercury (GO:0051597)2.84673524
94negative regulation of synaptic transmission, GABAergic (GO:0032229)2.83365940
95cerebellar Purkinje cell differentiation (GO:0021702)2.83348574
96regulation of synaptic transmission, glutamatergic (GO:0051966)2.83331332
97positive regulation of membrane potential (GO:0045838)2.83210635
98regulation of voltage-gated calcium channel activity (GO:1901385)2.82635115
99potassium ion import (GO:0010107)2.82108261
100presynaptic membrane organization (GO:0097090)2.81666428
101mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.80884484
102cerebellar Purkinje cell layer development (GO:0021680)2.79364694
103potassium ion homeostasis (GO:0055075)2.79319638
104negative regulation of microtubule polymerization (GO:0031115)2.78083537
105thalamus development (GO:0021794)2.78036135
106regulation of excitatory postsynaptic membrane potential (GO:0060079)2.75620214
107proline transport (GO:0015824)2.75227476
108fatty acid elongation (GO:0030497)2.74747784
109regulation of neurotransmitter secretion (GO:0046928)2.74005985
110cellular sodium ion homeostasis (GO:0006883)2.73114587
111regulation of neurotransmitter transport (GO:0051588)2.72534595
112negative regulation of axon extension (GO:0030517)2.72266936
113somite development (GO:0061053)2.71979381
114activation of protein kinase A activity (GO:0034199)2.71966162
115learning (GO:0007612)2.71941803
116synapse assembly (GO:0007416)2.71884502
117negative regulation of oligodendrocyte differentiation (GO:0048715)2.71576123
118synapse organization (GO:0050808)2.70774872
119negative regulation of axonogenesis (GO:0050771)2.70694216
120synaptic vesicle endocytosis (GO:0048488)2.70451367
121ATP synthesis coupled proton transport (GO:0015986)2.69909564
122energy coupled proton transport, down electrochemical gradient (GO:0015985)2.69909564
123regulation of neurotransmitter uptake (GO:0051580)2.69131814
124regulation of synaptic transmission, GABAergic (GO:0032228)2.68917250
125forebrain neuron differentiation (GO:0021879)2.67556740
126mechanosensory behavior (GO:0007638)2.66863998
127negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.65741013
128retinal ganglion cell axon guidance (GO:0031290)2.65314198
129neuronal stem cell maintenance (GO:0097150)2.64229314
130cellular response to cholesterol (GO:0071397)2.61946961
131lateral sprouting from an epithelium (GO:0060601)2.57484095
132appendage development (GO:0048736)2.55749280
133limb development (GO:0060173)2.55749280
134positive regulation of synapse assembly (GO:0051965)2.55380176
135paraxial mesoderm development (GO:0048339)2.54909854
136positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.54151144
137otic vesicle formation (GO:0030916)2.48617325
138lung-associated mesenchyme development (GO:0060484)2.47091255
139regulation of respiratory system process (GO:0044065)2.46727083
140dermatan sulfate biosynthetic process (GO:0030208)2.45656921
141neurofilament cytoskeleton organization (GO:0060052)2.42819289
142negative regulation of transcription regulatory region DNA binding (GO:2000678)2.42130353
143innervation (GO:0060384)2.39980689
144viral transcription (GO:0019083)2.39299854
145mitochondrion transport along microtubule (GO:0047497)2.36448866
146establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.36448866
147negative regulation of telomerase activity (GO:0051974)2.36255158
148neuron fate determination (GO:0048664)2.34380616
149neuromuscular synaptic transmission (GO:0007274)2.33704557
150epithelial cilium movement (GO:0003351)2.33647079
151protein polyglutamylation (GO:0018095)2.32866452
152positive regulation of gastrulation (GO:2000543)2.32751937
153mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.32153578
154positive regulation of potassium ion transmembrane transport (GO:1901381)2.31386434
155G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.31152471
156translational termination (GO:0006415)2.27733334
157cochlea development (GO:0090102)2.27508391
158hippocampus development (GO:0021766)2.26579471
159substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.24830487

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.88986751
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04688512
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04269163
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00094252
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79835329
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79835329
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.68823939
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.68010416
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64789628
10REST_21632747_ChIP-Seq_MESCs_Mouse2.55795230
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.55140571
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.51660305
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51099547
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48338217
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46770996
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44914345
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42260428
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.40552122
19DROSHA_22980978_ChIP-Seq_HELA_Human2.38713491
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.37078450
21GBX2_23144817_ChIP-Seq_PC3_Human2.36415259
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35644809
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.30952505
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.27289470
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.22504823
26ERG_21242973_ChIP-ChIP_JURKAT_Human2.18592102
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.16398859
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15324978
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.05603392
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.99511561
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95523122
32AR_21572438_ChIP-Seq_LNCaP_Human1.90822141
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81845467
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79018988
35RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.78826313
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62046733
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57308538
38SOX2_16153702_ChIP-ChIP_HESCs_Human1.56861263
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.56642180
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51108125
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49351210
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49157372
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45358904
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42986898
45RING1B_27294783_Chip-Seq_NPCs_Mouse1.42094952
46* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40588727
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33886774
48VDR_22108803_ChIP-Seq_LS180_Human1.32288474
49FUS_26573619_Chip-Seq_HEK293_Human1.31746408
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31405305
51KDM2B_26808549_Chip-Seq_K562_Human1.31085897
52WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30326592
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.29662256
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29547796
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27745147
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27254176
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26372107
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25146047
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21973419
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19864893
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19079523
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18030935
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.17267295
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16831843
65* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16226055
66SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15329614
67EWS_26573619_Chip-Seq_HEK293_Human1.14860998
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.14495752
69MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14012139
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.11148369
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10942752
72OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.10037817
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09324740
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08742599
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08742599
76KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08742599
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08694706
78TAF15_26573619_Chip-Seq_HEK293_Human1.07892552
79ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04996481
80AR_19668381_ChIP-Seq_PC3_Human1.04637487
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04344460
82SMAD4_21799915_ChIP-Seq_A2780_Human1.03759305
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03410926
84CTCF_27219007_Chip-Seq_Bcells_Human1.02706491
85* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02593855
86* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02093866
87IGF1R_20145208_ChIP-Seq_DFB_Human1.00966280
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00815465
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00453798
90POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00012775
91RNF2_27304074_Chip-Seq_NSC_Mouse0.99648450
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99577103
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99368164
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98514240
95NANOG_16153702_ChIP-ChIP_HESCs_Human0.98088455
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97484066
97ZNF274_21170338_ChIP-Seq_K562_Hela0.97179614
98* TET1_21490601_ChIP-Seq_MESCs_Mouse0.96662106
99TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95820797
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95318179
101NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95176958
102KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94926117
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93909560
104TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93094082
105STAT3_23295773_ChIP-Seq_U87_Human0.93072169
106FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92947235
107MYC_18940864_ChIP-ChIP_HL60_Human0.92483576
108TBX3_20139965_ChIP-Seq_ESCs_Mouse0.92235392
109SOX9_26525672_Chip-Seq_HEART_Mouse0.91092994
110EST1_17652178_ChIP-ChIP_JURKAT_Human0.90897548
111SMAD3_21741376_ChIP-Seq_ESCs_Human0.90280945
112P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90240799
113SMAD4_21741376_ChIP-Seq_HESCs_Human0.90145826
114BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90009450
115TP53_20018659_ChIP-ChIP_R1E_Mouse0.88719039
116TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87241332
117ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87042947
118GATA1_26923725_Chip-Seq_HPCs_Mouse0.86577568
119MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86545203
120IRF1_19129219_ChIP-ChIP_H3396_Human0.86407753
121GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85829865
122POU5F1_16518401_ChIP-PET_MESCs_Mouse0.85425422
123STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.85414758
124AHR_22903824_ChIP-Seq_MCF-7_Human0.85233330
125* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85059996
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84920788
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84920788
128P300_19829295_ChIP-Seq_ESCs_Human0.84431073
129CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84205282
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84060361
131* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.83835546
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.83690481
133SMAD4_21741376_ChIP-Seq_EPCs_Human0.83359926
134ARNT_22903824_ChIP-Seq_MCF-7_Human0.82524030
135YAP1_20516196_ChIP-Seq_MESCs_Mouse0.82481244
136CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.81404802
137PIAS1_25552417_ChIP-Seq_VCAP_Human0.81070638
138LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80125012
139KLF4_19829295_ChIP-Seq_ESCs_Human0.78255693
140RUNX2_22187159_ChIP-Seq_PCA_Human0.77244588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.01932644
2MP0003880_abnormal_central_pattern4.22607221
3MP0003635_abnormal_synaptic_transmissio3.53004724
4MP0002064_seizures3.12960398
5MP0009745_abnormal_behavioral_response3.06708469
6MP0005423_abnormal_somatic_nervous3.00799294
7MP0004270_analgesia2.98581398
8MP0001486_abnormal_startle_reflex2.88610615
9MP0002063_abnormal_learning/memory/cond2.86304515
10MP0009046_muscle_twitch2.77031636
11MP0002272_abnormal_nervous_system2.74349110
12MP0004885_abnormal_endolymph2.71462501
13MP0002822_catalepsy2.67320700
14MP0006292_abnormal_olfactory_placode2.53156202
15MP0002572_abnormal_emotion/affect_behav2.49101270
16MP0009379_abnormal_foot_pigmentation2.27965807
17MP0000778_abnormal_nervous_system2.24386848
18MP0001968_abnormal_touch/_nociception2.12009852
19MP0002734_abnormal_mechanical_nocicepti2.11492495
20MP0001440_abnormal_grooming_behavior2.09610907
21MP0003329_amyloid_beta_deposits2.08911064
22MP0000920_abnormal_myelination2.07475894
23MP0001485_abnormal_pinna_reflex2.03760922
24MP0003690_abnormal_glial_cell2.02680298
25MP0001188_hyperpigmentation1.91508351
26MP0001529_abnormal_vocalization1.91022462
27MP0004142_abnormal_muscle_tone1.88992068
28MP0004133_heterotaxia1.86737120
29MP0000049_abnormal_middle_ear1.82581665
30MP0002067_abnormal_sensory_capabilities1.77702213
31MP0008569_lethality_at_weaning1.77633368
32MP0000955_abnormal_spinal_cord1.72037866
33MP0003879_abnormal_hair_cell1.71679959
34MP0002733_abnormal_thermal_nociception1.71492427
35MP0001970_abnormal_pain_threshold1.68657909
36MP0004742_abnormal_vestibular_system1.67448287
37MP0004858_abnormal_nervous_system1.65761814
38MP0003119_abnormal_digestive_system1.63080932
39MP0001293_anophthalmia1.62532703
40MP0002638_abnormal_pupillary_reflex1.62303182
41MP0002736_abnormal_nociception_after1.60052675
42MP0002184_abnormal_innervation1.60008702
43MP0002882_abnormal_neuron_morphology1.59895604
44MP0002557_abnormal_social/conspecific_i1.58956019
45MP0003122_maternal_imprinting1.56392160
46MP0001501_abnormal_sleep_pattern1.54811860
47MP0004811_abnormal_neuron_physiology1.53184722
48MP0003634_abnormal_glial_cell1.52522117
49MP0001905_abnormal_dopamine_level1.51831535
50MP0001984_abnormal_olfaction1.51619712
51MP0005386_behavior/neurological_phenoty1.50452504
52MP0004924_abnormal_behavior1.50452504
53MP0000566_synostosis1.50014141
54MP0002066_abnormal_motor_capabilities/c1.49365079
55MP0003890_abnormal_embryonic-extraembry1.48085783
56MP0005623_abnormal_meninges_morphology1.43946925
57MP0006276_abnormal_autonomic_nervous1.42884020
58MP0008789_abnormal_olfactory_epithelium1.40095704
59MP0005646_abnormal_pituitary_gland1.40018210
60MP0001963_abnormal_hearing_physiology1.36353569
61MP0010030_abnormal_orbit_morphology1.35089412
62MP0006072_abnormal_retinal_apoptosis1.33402948
63MP0009780_abnormal_chondrocyte_physiolo1.29618897
64MP0002653_abnormal_ependyma_morphology1.29252827
65MP0003633_abnormal_nervous_system1.28954544
66MP0003937_abnormal_limbs/digits/tail_de1.28933924
67MP0002938_white_spotting1.28121298
68MP0005171_absent_coat_pigmentation1.27862489
69MP0002152_abnormal_brain_morphology1.27718656
70MP0003632_abnormal_nervous_system1.27002246
71MP0003787_abnormal_imprinting1.24566354
72MP0003631_nervous_system_phenotype1.23690040
73MP0002229_neurodegeneration1.23007535
74MP0002102_abnormal_ear_morphology1.22877011
75MP0002909_abnormal_adrenal_gland1.13436020
76MP0002249_abnormal_larynx_morphology1.10544754
77MP0002752_abnormal_somatic_nervous1.09693396
78MP0003878_abnormal_ear_physiology1.07655700
79MP0005377_hearing/vestibular/ear_phenot1.07655700
80MP0001177_atelectasis1.04920720
81MP0002751_abnormal_autonomic_nervous1.04226943
82MP0002697_abnormal_eye_size1.03088604
83MP0001502_abnormal_circadian_rhythm1.02570959
84MP0005551_abnormal_eye_electrophysiolog1.02039623
85MP0005645_abnormal_hypothalamus_physiol1.01830696
86MP0000631_abnormal_neuroendocrine_gland1.01586823
87MP0005394_taste/olfaction_phenotype1.00925746
88MP0005499_abnormal_olfactory_system1.00925746
89MP0002234_abnormal_pharynx_morphology0.97329942
90MP0001286_abnormal_eye_development0.97223955
91MP0000537_abnormal_urethra_morphology0.94045578
92MP0002735_abnormal_chemical_nociception0.92953695
93MP0000026_abnormal_inner_ear0.92499528
94MP0004145_abnormal_muscle_electrophysio0.92441050
95MP0002233_abnormal_nose_morphology0.92135809
96MP0003283_abnormal_digestive_organ0.91414814
97MP0009053_abnormal_anal_canal0.90127508
98MP0003942_abnormal_urinary_system0.89263863
99MP0000751_myopathy0.87855342
100MP0002090_abnormal_vision0.85268056
101MP0005391_vision/eye_phenotype0.84914408
102MP0002069_abnormal_eating/drinking_beha0.84509067
103MP0000604_amyloidosis0.84314321
104MP0000579_abnormal_nail_morphology0.84218057
105MP0003861_abnormal_nervous_system0.82759556
106MP0001299_abnormal_eye_distance/0.81149255
107MP0004134_abnormal_chest_morphology0.81141406
108MP0001986_abnormal_taste_sensitivity0.81122470
109MP0005167_abnormal_blood-brain_barrier0.81009667
110MP0003567_abnormal_fetal_cardiomyocyte0.80048336
111MP0003011_delayed_dark_adaptation0.79153663
112MP0003315_abnormal_perineum_morphology0.77436947
113MP0003137_abnormal_impulse_conducting0.75879567
114MP0002163_abnormal_gland_morphology0.75029143
115MP0002116_abnormal_craniofacial_bone0.72996799
116MP0000013_abnormal_adipose_tissue0.72869452
117MP0003755_abnormal_palate_morphology0.72563934
118MP0003123_paternal_imprinting0.69225825
119MP0003172_abnormal_lysosome_physiology0.69179435
120MP0008872_abnormal_physiological_respon0.68667218
121MP0005410_abnormal_fertilization0.67764575
122MP0001943_abnormal_respiration0.67035581
123MP0004085_abnormal_heartbeat0.65788620
124MP0003938_abnormal_ear_development0.62229735
125MP0004043_abnormal_pH_regulation0.62162322
126MP0003385_abnormal_body_wall0.61343780
127MP0003121_genomic_imprinting0.61172039
128MP0003136_yellow_coat_color0.60949563
129MP0008874_decreased_physiological_sensi0.60705189
130MP0008877_abnormal_DNA_methylation0.60187233
131MP0005195_abnormal_posterior_eye0.60114464
132MP0000639_abnormal_adrenal_gland0.59824476
133MP0005253_abnormal_eye_physiology0.59535490
134MP0005409_darkened_coat_color0.59513320

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.12620937
2Focal motor seizures (HP:0011153)5.62855913
3Focal seizures (HP:0007359)4.42323880
4Septo-optic dysplasia (HP:0100842)4.14076774
5Supranuclear gaze palsy (HP:0000605)4.12776206
6Ankle clonus (HP:0011448)4.04297549
7Atonic seizures (HP:0010819)3.72337021
8Neurofibrillary tangles (HP:0002185)3.67901363
9Visual hallucinations (HP:0002367)3.64616582
10Action tremor (HP:0002345)3.48752426
11Degeneration of the lateral corticospinal tracts (HP:0002314)3.39388031
12Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.39388031
13Abnormality of the corticospinal tract (HP:0002492)3.38148605
14Epileptic encephalopathy (HP:0200134)3.29496498
15Peripheral hypomyelination (HP:0007182)3.28821909
16Spastic gait (HP:0002064)3.16705544
17Generalized tonic-clonic seizures (HP:0002069)3.10715565
18Intention tremor (HP:0002080)3.09933248
19Febrile seizures (HP:0002373)3.05136292
20Cerebral inclusion bodies (HP:0100314)3.04674189
21Dysdiadochokinesis (HP:0002075)3.02351674
22Absence seizures (HP:0002121)2.99944999
23Dysmetria (HP:0001310)2.99506556
24Progressive cerebellar ataxia (HP:0002073)2.95041963
25Insidious onset (HP:0003587)2.93994861
26Termporal pattern (HP:0011008)2.93994861
27Megalencephaly (HP:0001355)2.85830505
28Abnormality of the labia minora (HP:0012880)2.85408312
29Dialeptic seizures (HP:0011146)2.84497249
30Pheochromocytoma (HP:0002666)2.76390589
31Anophthalmia (HP:0000528)2.74684164
32Scanning speech (HP:0002168)2.73140030
33Depression (HP:0000716)2.72689209
34Abnormal eating behavior (HP:0100738)2.70365625
35Maternal diabetes (HP:0009800)2.66744285
36Hemiparesis (HP:0001269)2.65926375
37Rib fusion (HP:0000902)2.65206976
38Pancreatic fibrosis (HP:0100732)2.63891282
39Urinary urgency (HP:0000012)2.63374167
40Oligodactyly (hands) (HP:0001180)2.62879802
41Impaired vibration sensation in the lower limbs (HP:0002166)2.59836147
42Colon cancer (HP:0003003)2.58960261
43Postural instability (HP:0002172)2.57552678
44True hermaphroditism (HP:0010459)2.57001380
45Optic nerve hypoplasia (HP:0000609)2.56471187
46Urinary bladder sphincter dysfunction (HP:0002839)2.56038384
47Esophageal atresia (HP:0002032)2.56017852
48Anxiety (HP:0000739)2.55610999
49Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.51676092
50Torticollis (HP:0000473)2.50866607
51Lower limb muscle weakness (HP:0007340)2.49683605
52Abnormality of the lower motor neuron (HP:0002366)2.45815324
53Cerebral hypomyelination (HP:0006808)2.45441174
54Nephronophthisis (HP:0000090)2.43245182
55Hepatoblastoma (HP:0002884)2.41872981
56Neuroendocrine neoplasm (HP:0100634)2.41424794
57Clonus (HP:0002169)2.39158543
58Absent septum pellucidum (HP:0001331)2.38438079
59Impaired social interactions (HP:0000735)2.37063600
60Abnormal social behavior (HP:0012433)2.37063600
61Limb dystonia (HP:0002451)2.35372365
62Abnormality of midbrain morphology (HP:0002418)2.34030883
63Molar tooth sign on MRI (HP:0002419)2.34030883
64Poor eye contact (HP:0000817)2.32966272
65Alacrima (HP:0000522)2.30903547
66Sclerocornea (HP:0000647)2.30574536
67Split foot (HP:0001839)2.29814006
68Pancreatic cysts (HP:0001737)2.25988233
69Insomnia (HP:0100785)2.24343453
70Annular pancreas (HP:0001734)2.23016305
71Broad-based gait (HP:0002136)2.22451989
72Mutism (HP:0002300)2.22230939
73Supernumerary spleens (HP:0009799)2.22211826
74Truncal ataxia (HP:0002078)2.22201913
75Gait imbalance (HP:0002141)2.18992532
76Focal dystonia (HP:0004373)2.18485987
77Progressive inability to walk (HP:0002505)2.12462382
78Aplasia involving bones of the extremities (HP:0009825)2.12431491
79Aplasia involving bones of the upper limbs (HP:0009823)2.12431491
80Aplasia of the phalanges of the hand (HP:0009802)2.12431491
81Generalized myoclonic seizures (HP:0002123)2.12188641
82Hemiplegia (HP:0002301)2.11557938
83Morphological abnormality of the pyramidal tract (HP:0002062)2.10686595
84Acute necrotizing encephalopathy (HP:0006965)2.10452427
85Bilateral microphthalmos (HP:0007633)2.10365027
86Partial duplication of thumb phalanx (HP:0009944)2.09791105
87Cutaneous finger syndactyly (HP:0010554)2.09315480
88Reticulocytopenia (HP:0001896)2.08016199
89Craniofacial dystonia (HP:0012179)2.07646764
90Stenosis of the external auditory canal (HP:0000402)2.07514758
91Vaginal atresia (HP:0000148)2.07286429
92Aplasia/Hypoplasia of the sternum (HP:0006714)2.05964302
93Anomalous pulmonary venous return (HP:0010772)2.05715507
94Congenital malformation of the right heart (HP:0011723)2.05698735
95Double outlet right ventricle (HP:0001719)2.05698735
96Gaze-evoked nystagmus (HP:0000640)2.04915121
97Anencephaly (HP:0002323)2.04751573
98Abnormality of cochlea (HP:0000375)2.04517144
99Oligodactyly (HP:0012165)2.04167680
100Hyperglycinemia (HP:0002154)2.03143111
101Gastrointestinal atresia (HP:0002589)2.02848516
102Postural tremor (HP:0002174)2.02061098
103Neoplasm of the peripheral nervous system (HP:0100007)2.01911538
104Pendular nystagmus (HP:0012043)2.01803906
105Genital tract atresia (HP:0001827)2.01622917
106Medial flaring of the eyebrow (HP:0010747)1.99697313
107Status epilepticus (HP:0002133)1.96016671
108Cutaneous syndactyly (HP:0012725)1.95814697
109Progressive macrocephaly (HP:0004481)1.95533661
110Clumsiness (HP:0002312)1.94249210
111Abnormality of the septum pellucidum (HP:0007375)1.94205546
112Abnormality of the diencephalon (HP:0010662)1.93771909
113Generalized hypotonia (HP:0001290)1.93373046
114Onion bulb formation (HP:0003383)1.92378869
115Amblyopia (HP:0000646)1.92169179
116Neuronal loss in central nervous system (HP:0002529)1.90884572
117Hemivertebrae (HP:0002937)1.90655330
118Chronic hepatic failure (HP:0100626)1.89731404
119Polyphagia (HP:0002591)1.89120629
120Morphological abnormality of the inner ear (HP:0011390)1.88350255
121Abnormality of the middle phalanges of the toes (HP:0010183)1.87011708
122Abnormal number of incisors (HP:0011064)1.86227971
123Intestinal atresia (HP:0011100)1.84994470
124Partial duplication of the phalanx of hand (HP:0009999)1.84889197
125Renal hypoplasia (HP:0000089)1.84274890
126Congenital primary aphakia (HP:0007707)1.83700503
127Bradykinesia (HP:0002067)1.82415511
128Abnormality of the renal medulla (HP:0100957)1.82130085
129Abnormal auditory evoked potentials (HP:0006958)1.81527423
130Decreased lacrimation (HP:0000633)1.81106223
131Acute encephalopathy (HP:0006846)1.80916251
132Retinal dysplasia (HP:0007973)1.80528769
133Bowel incontinence (HP:0002607)1.79952426
134Ventricular fibrillation (HP:0001663)1.79717550
135Abnormality of the 4th metacarpal (HP:0010012)1.79373101
136Type II lissencephaly (HP:0007260)1.79267847
137Aplasia/Hypoplasia of the spleen (HP:0010451)1.79164628
138Mixed hearing impairment (HP:0000410)1.78923435
139Asplenia (HP:0001746)1.78799856
140Holoprosencephaly (HP:0001360)1.78174885
141Delusions (HP:0000746)1.78024197
142Diplopia (HP:0000651)1.77364297
143Abnormality of binocular vision (HP:0011514)1.77364297
144Abnormality of cells of the erythroid lineage (HP:0012130)1.76802903
145Dynein arm defect of respiratory motile cilia (HP:0012255)1.75932148
146Absent/shortened dynein arms (HP:0200106)1.75932148
147Hypsarrhythmia (HP:0002521)1.75149053
148Abnormal mitochondria in muscle tissue (HP:0008316)1.74868947
149Specific learning disability (HP:0001328)1.72986738
150EEG with generalized epileptiform discharges (HP:0011198)1.72927719
151Abnormal number of erythroid precursors (HP:0012131)1.72787620
152Preaxial hand polydactyly (HP:0001177)1.72535580
153Hypogonadotrophic hypogonadism (HP:0000044)1.72094816
154Excessive salivation (HP:0003781)1.71347199
155Drooling (HP:0002307)1.71347199
156Abnormality of saccadic eye movements (HP:0000570)1.71327507
157Abnormality of the pulmonary veins (HP:0011718)1.70753571
158Cortical dysplasia (HP:0002539)1.70475932
159Synostosis of carpal bones (HP:0005048)1.68525606
160Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.68502151
161Nephrogenic diabetes insipidus (HP:0009806)1.68415845
162Leukodystrophy (HP:0002415)1.68334463
163Epileptiform EEG discharges (HP:0011182)1.68147929
164Impaired vibratory sensation (HP:0002495)1.68085499
165Hyperventilation (HP:0002883)1.68008771
166Hammertoe (HP:0001765)1.67466877
167Fetal akinesia sequence (HP:0001989)1.67144033
168Growth hormone deficiency (HP:0000824)1.66953408
169Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.66808832
170Abnormal drinking behavior (HP:0030082)1.66775148
171Polydipsia (HP:0001959)1.66775148
172Increased circulating renin level (HP:0000848)1.66621480
173Stereotypic behavior (HP:0000733)1.66487090
174Abnormal respiratory epithelium morphology (HP:0012253)1.65889485
175Abnormal respiratory motile cilium morphology (HP:0005938)1.65889485
176Vitreoretinal degeneration (HP:0000655)1.65346303
177Abnormal ciliary motility (HP:0012262)1.64385934
178Humeroradial synostosis (HP:0003041)1.64269872
179Synostosis involving the elbow (HP:0003938)1.64269872
180Optic nerve coloboma (HP:0000588)1.62721789
181Hypoplasia of the ulna (HP:0003022)1.61977159
182Choanal stenosis (HP:0000452)1.61936293
183Mitochondrial inheritance (HP:0001427)1.61465266
184Preaxial foot polydactyly (HP:0001841)1.61419723
185Cystic liver disease (HP:0006706)1.61262143
186Short hallux (HP:0010109)1.60334295

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.47028332
2TYRO33.44395035
3NTRK33.08125383
4MARK13.00733392
5MAP3K92.89127853
6MAP3K42.73454449
7MINK12.38115960
8UHMK12.36807349
9STK392.20061987
10NTRK22.16882894
11TNIK2.15335097
12PAK62.10448236
13CDC72.09032407
14DDR22.04009957
15PRKD32.03839684
16VRK21.96152987
17NTRK11.93646703
18KSR21.87298845
19MAP2K71.84655817
20FES1.81311495
21TAF11.74190283
22MAPK151.70408699
23DAPK21.67765094
24ICK1.60035163
25MAP2K41.59149072
26OXSR11.56006069
27MAPK131.54360944
28ZAK1.50315395
29CDK51.42924327
30SGK4941.42211388
31SGK2231.42211388
32STK161.41572251
33ADRBK21.39321376
34TSSK61.36852641
35PLK41.35586473
36MKNK21.35437309
37BMPR1B1.33807884
38PNCK1.33540360
39CAMKK11.32084546
40LIMK11.30301636
41ARAF1.28066588
42VRK11.27667998
43EPHB11.17752518
44PHKG11.16455474
45PHKG21.16455474
46PLK21.16336686
47GRK11.13483017
48MKNK11.13233947
49NME11.11674542
50KSR11.11289716
51CDK191.11035540
52EPHB21.10736746
53PINK11.10316660
54WNK11.09610356
55DYRK31.09108022
56MAP3K21.06778820
57PKN11.05192203
58CDK141.04106577
59PLK31.03878836
60CAMK1G1.01646022
61PRKCG1.00350375
62CASK0.99946821
63STK380.98024884
64CDK150.96833813
65CSNK1G20.96368631
66PRPF4B0.96236320
67BUB10.96150302
68GRK50.95972682
69IRAK20.95728592
70WEE10.95593786
71CDK180.94179584
72MAPKAPK50.93676657
73STK38L0.91040014
74ROCK20.90798911
75PAK30.89450008
76ALK0.87738204
77WNK40.87173954
78CAMK1D0.85276285
79CAMK2B0.84933769
80CDK11A0.84713942
81CAMK2A0.81912546
82LATS20.81809018
83MAP3K120.81746236
84NUAK10.79301852
85CSNK1G30.79165454
86STK110.76186215
87FGR0.75944617
88RET0.75848070
89INSRR0.75104354
90TLK10.74472727
91PBK0.74337095
92NEK60.72118664
93LMTK20.72073663
94NEK20.71428993
95TAOK10.70371617
96PRKCH0.68578619
97TTK0.68500043
98BCR0.67408084
99CSNK1A1L0.67017795
100MARK20.66500297
101CAMK2G0.65412437
102TRIM280.65196368
103PLK10.65184303
104MAP4K20.63892920
105BMX0.63022502
106PDPK10.61093134
107ROCK10.60536088
108WNK30.60445300
109CAMK2D0.59342068
110CHEK20.57989559
111CDK30.55290109
112SGK10.55066272
113CSNK1A10.55039955
114PRKCZ0.55035448
115PASK0.54410355
116TNK20.52952772
117DAPK10.52872543
118PRKDC0.51327095
119CSNK1G10.49980561
120ERBB20.49674698
121RPS6KA30.49410096
122DYRK1A0.49387785
123MAPK100.48890401
124FGFR20.48700666
125AURKA0.48108447
126FGFR10.47774912
127CDC42BPA0.47507501
128SIK20.46394446
129PDGFRA0.45961923
130SRPK10.45849802
131BRSK10.45504704
132SGK30.45356538
133FYN0.43574578
134SGK20.43428982
135DYRK20.43056820
136CAMK10.40803446
137PDGFRB0.39840397
138PDK10.39782630
139PRKCE0.38481651
140NEK10.37782488
141CSNK1E0.36473599

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.08597839
2Ribosome_Homo sapiens_hsa030102.89716281
3Nicotine addiction_Homo sapiens_hsa050332.81964509
4GABAergic synapse_Homo sapiens_hsa047272.78198628
5Nitrogen metabolism_Homo sapiens_hsa009102.67477411
6Glutamatergic synapse_Homo sapiens_hsa047242.40641366
7Olfactory transduction_Homo sapiens_hsa047402.25555578
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.16927548
9Morphine addiction_Homo sapiens_hsa050322.08665217
10Circadian entrainment_Homo sapiens_hsa047132.07167613
11Dopaminergic synapse_Homo sapiens_hsa047281.98653797
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98621636
13Huntingtons disease_Homo sapiens_hsa050161.96186001
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.87757435
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86709175
16Amphetamine addiction_Homo sapiens_hsa050311.84634269
17Long-term potentiation_Homo sapiens_hsa047201.83571751
18Cholinergic synapse_Homo sapiens_hsa047251.80656956
19RNA polymerase_Homo sapiens_hsa030201.69283190
20Cocaine addiction_Homo sapiens_hsa050301.66886972
21Salivary secretion_Homo sapiens_hsa049701.63436444
22Axon guidance_Homo sapiens_hsa043601.63027691
23Long-term depression_Homo sapiens_hsa047301.62206314
24Gastric acid secretion_Homo sapiens_hsa049711.62138907
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.61616226
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57430621
27Collecting duct acid secretion_Homo sapiens_hsa049661.55785218
28Serotonergic synapse_Homo sapiens_hsa047261.46836187
29Sulfur relay system_Homo sapiens_hsa041221.43174290
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42151490
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41827198
32Gap junction_Homo sapiens_hsa045401.37523638
33Insulin secretion_Homo sapiens_hsa049111.35507387
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32418981
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28513739
36Vitamin B6 metabolism_Homo sapiens_hsa007501.25833550
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25607609
38Renin secretion_Homo sapiens_hsa049241.24828506
39Homologous recombination_Homo sapiens_hsa034401.24027905
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21385630
41Oxytocin signaling pathway_Homo sapiens_hsa049211.21261661
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20641925
43Protein export_Homo sapiens_hsa030601.19864160
44Taste transduction_Homo sapiens_hsa047421.17564078
45Steroid biosynthesis_Homo sapiens_hsa001001.17337271
46Butanoate metabolism_Homo sapiens_hsa006501.17275472
47GnRH signaling pathway_Homo sapiens_hsa049121.16792007
48Selenocompound metabolism_Homo sapiens_hsa004501.14258904
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13123179
50Basal transcription factors_Homo sapiens_hsa030221.07914200
51Fanconi anemia pathway_Homo sapiens_hsa034601.07137021
52Ether lipid metabolism_Homo sapiens_hsa005651.06788695
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06606428
54Cardiac muscle contraction_Homo sapiens_hsa042601.03685694
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03128605
56Dorso-ventral axis formation_Homo sapiens_hsa043201.02346649
57Fatty acid biosynthesis_Homo sapiens_hsa000611.02232942
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02139988
59Mismatch repair_Homo sapiens_hsa034301.02080699
60cAMP signaling pathway_Homo sapiens_hsa040241.01523319
61Fatty acid elongation_Homo sapiens_hsa000621.01038563
62Spliceosome_Homo sapiens_hsa030401.00004180
63Vibrio cholerae infection_Homo sapiens_hsa051100.97486843
64Calcium signaling pathway_Homo sapiens_hsa040200.97001720
65RNA degradation_Homo sapiens_hsa030180.95839677
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95005315
67ErbB signaling pathway_Homo sapiens_hsa040120.94352070
68Estrogen signaling pathway_Homo sapiens_hsa049150.92883898
69Melanogenesis_Homo sapiens_hsa049160.91336850
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.90909316
71Glioma_Homo sapiens_hsa052140.89069049
72beta-Alanine metabolism_Homo sapiens_hsa004100.86821821
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.83934004
74Prion diseases_Homo sapiens_hsa050200.83071118
75Renal cell carcinoma_Homo sapiens_hsa052110.81182573
76Propanoate metabolism_Homo sapiens_hsa006400.80322374
77Base excision repair_Homo sapiens_hsa034100.79903809
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79715776
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79649106
80Choline metabolism in cancer_Homo sapiens_hsa052310.79450919
81DNA replication_Homo sapiens_hsa030300.78937992
82Notch signaling pathway_Homo sapiens_hsa043300.78801361
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77150506
84Arginine and proline metabolism_Homo sapiens_hsa003300.76767298
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.76091246
86Hedgehog signaling pathway_Homo sapiens_hsa043400.75724010
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74828088
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73609722
89Oocyte meiosis_Homo sapiens_hsa041140.73554952
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.72107048
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72087638
92Parkinsons disease_Homo sapiens_hsa050120.72039478
93Oxidative phosphorylation_Homo sapiens_hsa001900.72033769
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71290355
95Bile secretion_Homo sapiens_hsa049760.70770205
96Type II diabetes mellitus_Homo sapiens_hsa049300.69688536
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69109328
98Proteasome_Homo sapiens_hsa030500.68206872
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67070920
100RNA transport_Homo sapiens_hsa030130.66935654
101Linoleic acid metabolism_Homo sapiens_hsa005910.66414647
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66248288
103Tight junction_Homo sapiens_hsa045300.64571458
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.62294273
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62059214
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61779136
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60101242
108Folate biosynthesis_Homo sapiens_hsa007900.59730544
109Alzheimers disease_Homo sapiens_hsa050100.58160671
110Ovarian steroidogenesis_Homo sapiens_hsa049130.57455493
111mRNA surveillance pathway_Homo sapiens_hsa030150.57187618
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56566659
113Thyroid hormone synthesis_Homo sapiens_hsa049180.56041482
114Arginine biosynthesis_Homo sapiens_hsa002200.54807049
115Endocytosis_Homo sapiens_hsa041440.54630286
116Ras signaling pathway_Homo sapiens_hsa040140.54619516
117Purine metabolism_Homo sapiens_hsa002300.54453957
118Pyruvate metabolism_Homo sapiens_hsa006200.53627138
119Hippo signaling pathway_Homo sapiens_hsa043900.52536952
120Peroxisome_Homo sapiens_hsa041460.51744151
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50981138
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.50481927
123Pancreatic secretion_Homo sapiens_hsa049720.49199456
124MAPK signaling pathway_Homo sapiens_hsa040100.47440853
125Metabolic pathways_Homo sapiens_hsa011000.46306933
126Wnt signaling pathway_Homo sapiens_hsa043100.45981442
127Alcoholism_Homo sapiens_hsa050340.44688747
128Endometrial cancer_Homo sapiens_hsa052130.44556759
129Phototransduction_Homo sapiens_hsa047440.44355983
130Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44002650
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43579733
132Fatty acid metabolism_Homo sapiens_hsa012120.43313188
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42890276
134Cell cycle_Homo sapiens_hsa041100.40721247
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40294787
136Dilated cardiomyopathy_Homo sapiens_hsa054140.39579438
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38998775
138Rap1 signaling pathway_Homo sapiens_hsa040150.38120505
139VEGF signaling pathway_Homo sapiens_hsa043700.37492546
140Basal cell carcinoma_Homo sapiens_hsa052170.36597492
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.36507550
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35775317

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