RNF10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.00076774
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.00076774
3oxygen transport (GO:0015671)4.47231137
4positive regulation of gamma-delta T cell activation (GO:0046645)4.45631175
53-UTR-mediated mRNA stabilization (GO:0070935)4.35986729
6negative regulation of erythrocyte differentiation (GO:0045647)4.20066755
7negative regulation of cell size (GO:0045792)4.09889014
8plasma membrane repair (GO:0001778)4.07155879
9positive regulation by symbiont of host defense response (GO:0052509)4.01958242
10modulation by symbiont of host defense response (GO:0052031)4.01958242
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.01958242
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.01958242
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.01958242
14modulation by symbiont of host immune response (GO:0052553)4.01958242
15negative regulation of necroptotic process (GO:0060546)4.01214200
16hemoglobin metabolic process (GO:0020027)3.99072495
17cytoskeletal anchoring at plasma membrane (GO:0007016)3.96302692
18regulation of necroptotic process (GO:0060544)3.95042449
19negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.91533036
20peptidyl-lysine dimethylation (GO:0018027)3.88060801
21regulation of hippo signaling (GO:0035330)3.87393660
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.76380740
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.74843307
24regulation of B cell receptor signaling pathway (GO:0050855)3.74360835
25erythrocyte development (GO:0048821)3.72800322
26gas transport (GO:0015669)3.70500561
27negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.66564891
28lysine metabolic process (GO:0006553)3.57557499
29lysine catabolic process (GO:0006554)3.57557499
30detection of other organism (GO:0098543)3.48462084
31negative regulation of potassium ion transmembrane transport (GO:1901380)3.48075837
32carnitine shuttle (GO:0006853)3.47121019
33positive regulation of receptor recycling (GO:0001921)3.42033879
34antigen processing and presentation of endogenous antigen (GO:0019883)3.40503212
35leukocyte aggregation (GO:0070486)3.35746677
36histone H3-K36 demethylation (GO:0070544)3.33535014
37neutrophil activation involved in immune response (GO:0002283)3.32556821
38detection of bacterium (GO:0016045)3.30956047
39antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.28429209
40hepatocyte apoptotic process (GO:0097284)3.27857591
41cardiac myofibril assembly (GO:0055003)3.24793459
42regulation of gamma-delta T cell activation (GO:0046643)3.24208994
43negative regulation of necrotic cell death (GO:0060547)3.23822951
44regulation of platelet aggregation (GO:0090330)3.21652072
45sarcomere organization (GO:0045214)3.21073562
46adherens junction assembly (GO:0034333)3.17763374
47pre-miRNA processing (GO:0031054)3.17697020
48protoporphyrinogen IX metabolic process (GO:0046501)3.15715014
49modulation by virus of host process (GO:0019054)3.14898920
50positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.14831658
51regulation of gamma-delta T cell differentiation (GO:0045586)3.14212506
52negative regulation of lymphocyte mediated immunity (GO:0002707)3.13586799
53fatty acid transmembrane transport (GO:1902001)3.11646442
54macrophage activation involved in immune response (GO:0002281)3.10643632
55regulation of cholesterol homeostasis (GO:2000188)3.09290018
56positive regulation of Cdc42 GTPase activity (GO:0043089)3.08658425
57response to peptidoglycan (GO:0032494)3.06236016
58maternal placenta development (GO:0001893)3.05504480
59regulation of fatty acid beta-oxidation (GO:0031998)3.04665322
60modulation by symbiont of host cellular process (GO:0044068)3.04320203
61activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.03574905
62regulation of necrotic cell death (GO:0010939)3.01598109
63detection of external biotic stimulus (GO:0098581)3.00923227
64detection of molecule of bacterial origin (GO:0032490)2.99976645
65positive regulation of histone deacetylation (GO:0031065)2.99775364
66protein localization to endosome (GO:0036010)2.99465667
67focal adhesion assembly (GO:0048041)2.98102397
68cell-substrate adherens junction assembly (GO:0007045)2.98102397
69regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.96749493
70regulation of mast cell degranulation (GO:0043304)2.96009711
71aspartate family amino acid catabolic process (GO:0009068)2.95077090
72negative regulation of leukocyte mediated immunity (GO:0002704)2.93025620
73positive regulation of nuclease activity (GO:0032075)2.92576886
74polarized epithelial cell differentiation (GO:0030859)2.92224222
75carnitine transmembrane transport (GO:1902603)2.91094049
76cellular extravasation (GO:0045123)2.91042762
77cellular response to virus (GO:0098586)2.90896220
78regulation of response to osmotic stress (GO:0047484)2.90306630
79regulation of leukocyte degranulation (GO:0043300)2.89556640
80regulation of p38MAPK cascade (GO:1900744)2.89335360
81myeloid cell development (GO:0061515)2.89242077
82positive thymic T cell selection (GO:0045059)2.88638204
834-hydroxyproline metabolic process (GO:0019471)2.87375771
84amino-acid betaine transport (GO:0015838)2.86551303
85carnitine transport (GO:0015879)2.86551303
86regulation of myeloid leukocyte mediated immunity (GO:0002886)2.86495002
87negative regulation of cAMP-mediated signaling (GO:0043951)2.84573266
88positive regulation of granulocyte differentiation (GO:0030854)2.84355901
89erythrocyte maturation (GO:0043249)2.83641990
90regulation of translational fidelity (GO:0006450)2.83244611
91epithelial cell-cell adhesion (GO:0090136)2.82119987
92regulation of translational termination (GO:0006449)2.80644988
93stress fiber assembly (GO:0043149)2.79542185
94paraxial mesoderm development (GO:0048339)2.77687944
95positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.77394995
96response to muramyl dipeptide (GO:0032495)2.76560158
97germinal center formation (GO:0002467)2.75289182
98cell-substrate junction assembly (GO:0007044)2.75156508
99regulation of regulated secretory pathway (GO:1903305)2.74079703
100response to interleukin-15 (GO:0070672)2.73980241
101regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.73051818
1022-oxoglutarate metabolic process (GO:0006103)2.72939795
103negative regulation of heart growth (GO:0061117)2.72040313
104negative regulation of cardiac muscle tissue growth (GO:0055022)2.72040313
105negative regulation of T cell mediated immunity (GO:0002710)2.71187610
106response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.70612590
107response to host immune response (GO:0052572)2.70612590
108respiratory burst (GO:0045730)2.69214054
109response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.67823926
110response to host (GO:0075136)2.67823926
111response to host defenses (GO:0052200)2.67823926
112negative regulation of interleukin-12 production (GO:0032695)2.66431117
113heterochromatin organization (GO:0070828)2.65318776
114positive regulation of fatty acid beta-oxidation (GO:0032000)2.65181044
115negative regulation of nucleotide catabolic process (GO:0030812)2.64817392
116microglial cell activation (GO:0001774)2.64256977
117B cell receptor signaling pathway (GO:0050853)2.63849937
118apoptotic process involved in morphogenesis (GO:0060561)2.63664238
119neutrophil mediated immunity (GO:0002446)2.63602157
120cellular response to epinephrine stimulus (GO:0071872)2.62622373
121regulation of mast cell activation involved in immune response (GO:0033006)2.60615846
122porphyrin-containing compound biosynthetic process (GO:0006779)2.60139081
123hippo signaling (GO:0035329)2.59322335
124protein hydroxylation (GO:0018126)2.58476977
125regulation of interferon-beta biosynthetic process (GO:0045357)2.58368799
126leukocyte migration involved in inflammatory response (GO:0002523)2.58284749
127regulation of fatty acid oxidation (GO:0046320)2.57920949
128intracellular estrogen receptor signaling pathway (GO:0030520)2.57066915
129NLS-bearing protein import into nucleus (GO:0006607)2.57046089
130regulation of nuclease activity (GO:0032069)2.56693356
131low-density lipoprotein particle clearance (GO:0034383)2.56601325
132myofibril assembly (GO:0030239)2.55905645
133detection of biotic stimulus (GO:0009595)2.55899128
134neutrophil activation (GO:0042119)2.55773017
135histone H3-K9 demethylation (GO:0033169)2.55405011
136regulation of amyloid precursor protein catabolic process (GO:1902991)2.55265771
137creatine metabolic process (GO:0006600)2.53553490
138macrophage activation (GO:0042116)2.51063179
139bundle of His cell to Purkinje myocyte communication (GO:0086069)2.50995757
140L-alpha-amino acid transmembrane transport (GO:1902475)2.50423366
141positive regulation of Rap GTPase activity (GO:0032854)2.49979695
142mRNA stabilization (GO:0048255)2.49790964
143RNA stabilization (GO:0043489)2.49790964
144cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.49565814
145cellular hyperosmotic response (GO:0071474)2.49111603
146negative regulation of myotube differentiation (GO:0010832)2.48785305
147tricarboxylic acid cycle (GO:0006099)2.48182690
148establishment of apical/basal cell polarity (GO:0035089)2.47800826
149alpha-linolenic acid metabolic process (GO:0036109)2.45548340
150regulation of tight junction assembly (GO:2000810)2.45147607
151negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.45022222
152ventricular cardiac muscle cell action potential (GO:0086005)2.44426746
153granulocyte activation (GO:0036230)2.43340121
154negative regulation of phagocytosis (GO:0050765)2.43148100
155histone lysine demethylation (GO:0070076)2.42953221
156endoplasmic reticulum unfolded protein response (GO:0030968)2.42753950
157positive regulation of fibroblast migration (GO:0010763)2.42605566
158positive T cell selection (GO:0043368)2.41448267
159regulation of defense response to virus by virus (GO:0050690)2.41366612
160protoporphyrinogen IX biosynthetic process (GO:0006782)2.41195676
161regulation of T-helper 2 cell differentiation (GO:0045628)2.40640450
162thymic T cell selection (GO:0045061)2.40051616
163pentose-phosphate shunt (GO:0006098)2.39407371
164establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.39320840
165negative regulation of fatty acid transport (GO:2000192)2.39082919
166growth hormone secretion (GO:0030252)2.38058766
167peptidyl-proline hydroxylation (GO:0019511)2.37091374
168cell communication involved in cardiac conduction (GO:0086065)2.36820626
169cardiac muscle cell development (GO:0055013)2.36034456
170cell communication by electrical coupling (GO:0010644)2.35251200
171positive regulation of glycogen biosynthetic process (GO:0045725)2.33620485
172insulin-like growth factor receptor signaling pathway (GO:0048009)2.32627716
173actomyosin structure organization (GO:0031032)2.31803538
174tricarboxylic acid metabolic process (GO:0072350)2.31750376
175apoptotic cell clearance (GO:0043277)2.31458206
176protein targeting to plasma membrane (GO:0072661)2.29166461
177regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.27992903
178positive regulation of triglyceride biosynthetic process (GO:0010867)2.27803194
179ER-nucleus signaling pathway (GO:0006984)2.27529694
180cellular response to unfolded protein (GO:0034620)2.27434099
181cardiac muscle contraction (GO:0060048)2.25517693
182negative regulation of purine nucleotide catabolic process (GO:0033122)2.24908203
183negative regulation of lipid transport (GO:0032369)2.24521893
184muscle filament sliding (GO:0030049)2.23935025
185actin-myosin filament sliding (GO:0033275)2.23935025
186heart trabecula formation (GO:0060347)2.23898925
187tetrapyrrole biosynthetic process (GO:0033014)2.22387237
188cell migration involved in sprouting angiogenesis (GO:0002042)2.21613768
189acetyl-CoA metabolic process (GO:0006084)2.19969855
190sodium ion export (GO:0071436)2.19894572
191regulation of cardioblast differentiation (GO:0051890)2.19876556
192quaternary ammonium group transport (GO:0015697)2.19726328
193Golgi transport vesicle coating (GO:0048200)2.18774399
194COPI coating of Golgi vesicle (GO:0048205)2.18774399

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.92341766
2ZNF263_19887448_ChIP-Seq_K562_Human2.89484863
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.85846815
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.84293777
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.63710192
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.49808551
7MYC_22102868_ChIP-Seq_BL_Human2.46799939
8KDM2B_26808549_Chip-Seq_DND41_Human2.35806786
9ZFP281_18757296_ChIP-ChIP_E14_Mouse2.28981815
10SCL_19346495_ChIP-Seq_HPC-7_Human2.27984692
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.27576619
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.26187899
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.26133824
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24760313
15LXR_22292898_ChIP-Seq_THP-1_Human2.24100959
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22868244
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.21871698
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.18880811
19VDR_24763502_ChIP-Seq_THP-1_Human2.15107932
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.13303514
21MAF_26560356_Chip-Seq_TH1_Human2.13251407
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.06790268
23KDM2B_26808549_Chip-Seq_K562_Human2.02053006
24RARG_19884340_ChIP-ChIP_MEFs_Mouse2.01338862
25CLOCK_20551151_ChIP-Seq_293T_Human1.99399398
26* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.96818937
27TCF7_22412390_ChIP-Seq_EML_Mouse1.96722385
28ELK3_25401928_ChIP-Seq_HUVEC_Human1.95395754
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.94867223
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.94364719
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.94134415
32GATA1_22025678_ChIP-Seq_K562_Human1.92363412
33RACK7_27058665_Chip-Seq_MCF-7_Human1.88753848
34* RXR_22158963_ChIP-Seq_LIVER_Mouse1.88175949
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.87964678
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86919019
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.86830299
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.86697116
39SPI1_23127762_ChIP-Seq_K562_Human1.85418050
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85384019
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.82549642
42* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.80187601
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76756206
44P300_27058665_Chip-Seq_ZR-75-30cells_Human1.75777231
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.73803239
46GATA1_22383799_ChIP-Seq_G1ME_Mouse1.73311268
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.73115837
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71999109
49* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.70213020
50GATA1_19941826_ChIP-Seq_K562_Human1.68946827
51* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.66508153
52ATF3_27146783_Chip-Seq_COLON_Human1.65387033
53CREB1_26743006_Chip-Seq_LNCaP_Human1.65253956
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64371626
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.62470960
56EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.61842633
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59940493
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.59470106
59MAF_26560356_Chip-Seq_TH2_Human1.59294933
60LXR_22158963_ChIP-Seq_LIVER_Mouse1.58730560
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57052880
62RUNX_20019798_ChIP-Seq_JUKART_Human1.56703205
63IRF8_27001747_Chip-Seq_BMDM_Mouse1.55756145
64CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.54185460
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.53968816
66VDR_21846776_ChIP-Seq_THP-1_Human1.52953256
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.52676843
68P68_20966046_ChIP-Seq_HELA_Human1.51814225
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51172164
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51023826
71SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.46969535
72DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.46721695
73TBX20_22080862_ChIP-Seq_HEART_Mouse1.45003476
74TBX20_22328084_ChIP-Seq_HEART_Mouse1.45003476
75* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.44168729
76SPI1_23547873_ChIP-Seq_NB4_Human1.41306975
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40477393
78STAT4_19710469_ChIP-ChIP_TH1__Mouse1.39780705
79MYB_26560356_Chip-Seq_TH1_Human1.39625248
80GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39213929
81* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38508572
82* MYB_26560356_Chip-Seq_TH2_Human1.37353910
83NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36945136
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34777734
85NCOR1_26117541_ChIP-Seq_K562_Human1.34665093
86STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32780577
87TP53_22127205_ChIP-Seq_IMR90_Human1.32545453
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32447294
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31567552
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.30940266
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30896965
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30861270
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30158056
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.28000869
95EGR1_19374776_ChIP-ChIP_THP-1_Human1.26531770
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26278695
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26132735
98EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.26129719
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25775426
100SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24949329
101SMC4_20622854_ChIP-Seq_HELA_Human1.23432809
102STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22996865
103GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22906590
104ELF1_20517297_ChIP-Seq_JURKAT_Human1.22760297
105CTCF_27219007_Chip-Seq_Bcells_Human1.22629897
106SMAD_19615063_ChIP-ChIP_OVARY_Human1.22551196
107TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.21087586
108IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20153314
109FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.18640047
110IRF8_21731497_ChIP-ChIP_J774_Mouse1.18194524
111PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17778481
112LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17106746
113GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16748069
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16291439
115GATA1_19941827_ChIP-Seq_MEL_Mouse1.15316906
116* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14976252
117SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13809568
118CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12151803
119TP63_22573176_ChIP-Seq_HFKS_Human1.10921796
120TRIM28_21343339_ChIP-Seq_HEK293_Human1.10808919
121KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.10706358
122TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09805314
123FOXO3_23340844_ChIP-Seq_DLD1_Human1.09527886
124NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08745736
125* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08613592
126HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08548789
127RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08539077
128ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08384753
129SA1_27219007_Chip-Seq_ERYTHROID_Human1.07239487
130PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06838324
131TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06617122
132* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06547551
133GATA6_25053715_ChIP-Seq_YYC3_Human1.05747493
134PU_27001747_Chip-Seq_BMDM_Mouse1.04418544
135NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.04412046
136CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03910886
137SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02109257
138GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.02049856
139SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01690004
140CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01620966
141MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01284673
142BCOR_27268052_Chip-Seq_Bcells_Human1.00367830
143STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00072048
144KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99960118
145ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99929005
146UTX_26944678_Chip-Seq_JUKART_Human0.99081658
147* GATA2_19941826_ChIP-Seq_K562_Human0.97640409
148ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97207744

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008260_abnormal_autophagy4.45676488
2MP0003705_abnormal_hypodermis_morpholog4.25366086
3MP0005451_abnormal_body_composition4.13746785
4MP0003436_decreased_susceptibility_to3.10015873
5MP0003724_increased_susceptibility_to2.96420620
6MP0002837_dystrophic_cardiac_calcinosis2.96109789
7MP0003646_muscle_fatigue2.68155219
8MP0004185_abnormal_adipocyte_glucose2.64595968
9MP0000751_myopathy2.62018215
10MP0004084_abnormal_cardiac_muscle2.51798155
11MP0005076_abnormal_cell_differentiation2.18715850
12MP0004510_myositis2.16776404
13MP0003191_abnormal_cellular_cholesterol2.15510152
14MP0005666_abnormal_adipose_tissue2.10221614
15MP0005377_hearing/vestibular/ear_phenot2.08601697
16MP0003878_abnormal_ear_physiology2.08601697
17MP0004130_abnormal_muscle_cell2.08511209
18MP0003566_abnormal_cell_adhesion2.07439311
19MP0005464_abnormal_platelet_physiology2.07284028
20MP0003172_abnormal_lysosome_physiology2.02642427
21MP0008961_abnormal_basal_metabolism2.02024985
22MP0004087_abnormal_muscle_fiber2.01969524
23MP0004233_abnormal_muscle_weight2.00862743
24MP0002419_abnormal_innate_immunity1.96656375
25MP0002332_abnormal_exercise_endurance1.95839721
26MP0003828_pulmonary_edema1.91667173
27MP0003656_abnormal_erythrocyte_physiolo1.86774579
28MP0005083_abnormal_biliary_tract1.86714982
29MP0003283_abnormal_digestive_organ1.84941642
30MP0003763_abnormal_thymus_physiology1.81044970
31MP0005025_abnormal_response_to1.79928101
32MP0004036_abnormal_muscle_relaxation1.77427117
33MP0000685_abnormal_immune_system1.76842181
34MP0001849_ear_inflammation1.76533973
35MP0010352_gastrointestinal_tract_polyps1.72625077
36MP0005330_cardiomyopathy1.71516161
37MP0000747_muscle_weakness1.71239056
38MP0002269_muscular_atrophy1.68683633
39MP0010234_abnormal_vibrissa_follicle1.68146730
40MP0000750_abnormal_muscle_regeneration1.66955779
41MP0004947_skin_inflammation1.65137024
42MP0005623_abnormal_meninges_morphology1.62704582
43MP0000749_muscle_degeneration1.61664485
44MP0005375_adipose_tissue_phenotype1.61133205
45MP0000733_abnormal_muscle_development1.59394045
46MP0010630_abnormal_cardiac_muscle1.58624133
47MP0002398_abnormal_bone_marrow1.58540514
48MP0002139_abnormal_hepatobiliary_system1.57099141
49MP0001835_abnormal_antigen_presentation1.56298801
50MP0002653_abnormal_ependyma_morphology1.56079031
51MP0005397_hematopoietic_system_phenotyp1.55925850
52MP0001545_abnormal_hematopoietic_system1.55925850
53MP0002420_abnormal_adaptive_immunity1.55042109
54MP0001800_abnormal_humoral_immune1.53367919
55MP0005000_abnormal_immune_tolerance1.52162984
56MP0001819_abnormal_immune_cell1.52084008
57MP0000759_abnormal_skeletal_muscle1.47350643
58MP0001790_abnormal_immune_system1.46920109
59MP0005387_immune_system_phenotype1.46920109
60MP0004147_increased_porphyrin_level1.43344939
61MP0004858_abnormal_nervous_system1.41241537
62MP0002877_abnormal_melanocyte_morpholog1.41189725
63MP0000537_abnormal_urethra_morphology1.40490030
64MP0002723_abnormal_immune_serum1.38246879
65MP0005058_abnormal_lysosome_morphology1.36406736
66MP0002405_respiratory_system_inflammati1.36020408
67MP0003300_gastrointestinal_ulcer1.33568207
68MP0003091_abnormal_cell_migration1.33374405
69MP0002106_abnormal_muscle_physiology1.32113673
70MP0002722_abnormal_immune_system1.31507635
71MP0009278_abnormal_bone_marrow1.31465409
72MP0008775_abnormal_heart_ventricle1.30951985
73MP0002452_abnormal_antigen_presenting1.30385160
74MP0001533_abnormal_skeleton_physiology1.30359071
75MP0005670_abnormal_white_adipose1.30286294
76MP0005360_urolithiasis1.28904355
77MP0006138_congestive_heart_failure1.28546890
78MP0002396_abnormal_hematopoietic_system1.28155215
79MP0009785_altered_susceptibility_to1.27453017
80MP0000858_altered_metastatic_potential1.26693555
81MP0000716_abnormal_immune_system1.25768840
82MP0000703_abnormal_thymus_morphology1.25618688
83MP0003221_abnormal_cardiomyocyte_apopto1.25452237
84MP0009672_abnormal_birth_weight1.23421831
85MP0002796_impaired_skin_barrier1.21844139
86MP0009053_abnormal_anal_canal1.21551119
87MP0000003_abnormal_adipose_tissue1.20847049
88MP0000689_abnormal_spleen_morphology1.20746267
89MP0004381_abnormal_hair_follicle1.20639700
90MP0008438_abnormal_cutaneous_collagen1.19796049
91MP0005620_abnormal_muscle_contractility1.19028834
92MP0009840_abnormal_foam_cell1.17377748
93MP0004215_abnormal_myocardial_fiber1.16723103
94MP0002429_abnormal_blood_cell1.16389453
95MP0003119_abnormal_digestive_system1.15499195
96MP0002234_abnormal_pharynx_morphology1.15355892
97MP0003303_peritoneal_inflammation1.15344633
98MP0003453_abnormal_keratinocyte_physiol1.14880667
99MP0001730_embryonic_growth_arrest1.14427348
100MP0003866_abnormal_defecation1.13547923
101MP0001544_abnormal_cardiovascular_syste1.13459671
102MP0005385_cardiovascular_system_phenoty1.13459671
103MP0004808_abnormal_hematopoietic_stem1.12541678
104MP0004197_abnormal_fetal_growth/weight/1.11525994
105MP0002084_abnormal_developmental_patter1.11378068
106MP0002972_abnormal_cardiac_muscle1.10193909
107MP0005275_abnormal_skin_tensile1.10144103
108MP0009333_abnormal_splenocyte_physiolog1.09829362
109MP0004145_abnormal_muscle_electrophysio1.08102883
110MP0009780_abnormal_chondrocyte_physiolo1.07827889
111MP0005365_abnormal_bile_salt1.06676523
112MP0002909_abnormal_adrenal_gland1.05243709
113MP0004484_altered_response_of1.04480258
114MP0001851_eye_inflammation1.04393360
115MP0000465_gastrointestinal_hemorrhage1.04129797
116MP0005085_abnormal_gallbladder_physiolo1.03841472
117MP0010329_abnormal_lipoprotein_level1.03431097
118MP0003984_embryonic_growth_retardation1.03300249
119MP0000266_abnormal_heart_morphology1.03211184
120MP0003115_abnormal_respiratory_system1.02954346
121MP0002088_abnormal_embryonic_growth/wei1.02862373
122MP0010155_abnormal_intestine_physiology1.02353314
123MP0005369_muscle_phenotype1.00571526
124MP0001672_abnormal_embryogenesis/_devel1.00258576
125MP0005380_embryogenesis_phenotype1.00258576
126MP0008874_decreased_physiological_sensi0.98399809
127MP0004272_abnormal_basement_membrane0.98337935
128MP0002166_altered_tumor_susceptibility0.97101783
129MP0002085_abnormal_embryonic_tissue0.97002360
130MP0003183_abnormal_peptide_metabolism0.96573369
131MP0002132_abnormal_respiratory_system0.96035134
132MP0002086_abnormal_extraembryonic_tissu0.95516397
133MP0005187_abnormal_penis_morphology0.92815461
134MP0005501_abnormal_skin_physiology0.92443900
135MP0001845_abnormal_inflammatory_respons0.92333980
136MP0003252_abnormal_bile_duct0.91264230
137MP0008770_decreased_survivor_rate0.91082431
138MP0005310_abnormal_salivary_gland0.90863136
139MP0004883_abnormal_blood_vessel0.89422201
140MP0005621_abnormal_cell_physiology0.89223414
141MP0002925_abnormal_cardiovascular_devel0.89093850
142MP0003567_abnormal_fetal_cardiomyocyte0.89078533
143MP0003690_abnormal_glial_cell0.87870365
144MP0010030_abnormal_orbit_morphology0.87323864
145MP0002089_abnormal_postnatal_growth/wei0.86986276
146MP0000604_amyloidosis0.86485593
147MP0001697_abnormal_embryo_size0.86146075
148MP0004085_abnormal_heartbeat0.85702729
149MP0002998_abnormal_bone_remodeling0.85137644
150MP0006082_CNS_inflammation0.83110243
151MP0003075_altered_response_to0.81504871
152MP0003329_amyloid_beta_deposits0.80710926
153MP0003137_abnormal_impulse_conducting0.80346576
154MP0003045_fibrosis0.79217936
155MP0008004_abnormal_stomach_pH0.78972034
156MP0002896_abnormal_bone_mineralization0.78921902
157MP0000609_abnormal_liver_physiology0.78343882
158MP0002080_prenatal_lethality0.78110113
159MP0000534_abnormal_ureter_morphology0.77483741
160MP0002148_abnormal_hypersensitivity_rea0.76875203
161MP0010368_abnormal_lymphatic_system0.75005851
162MP0005167_abnormal_blood-brain_barrier0.74732784
163MP0002971_abnormal_brown_adipose0.74536598
164MP0003279_aneurysm0.73707831
165MP0008469_abnormal_protein_level0.73198944

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)5.26366393
2Abnormality of the heme biosynthetic pathway (HP:0010472)4.38766365
3Eczematoid dermatitis (HP:0000976)4.27912095
4Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.94997370
5Increased connective tissue (HP:0009025)3.63228196
6Hyporeflexia of lower limbs (HP:0002600)3.57313616
7Microcytic anemia (HP:0001935)3.49034256
8Hypochromic anemia (HP:0001931)3.47825225
9Sudden death (HP:0001699)3.43047897
10Exercise-induced myalgia (HP:0003738)3.39720703
11Difficulty running (HP:0009046)3.36412008
12Recurrent abscess formation (HP:0002722)3.33178158
13Recurrent bacterial skin infections (HP:0005406)3.27319918
14Gastrointestinal infarctions (HP:0005244)3.19291446
15Difficulty climbing stairs (HP:0003551)3.18084008
16Exercise-induced muscle cramps (HP:0003710)3.10706931
17Abnormality of macrophages (HP:0004311)3.08684421
18Slow saccadic eye movements (HP:0000514)3.07670300
19Muscle fiber splitting (HP:0003555)3.06822270
20Centrally nucleated skeletal muscle fibers (HP:0003687)3.06305480
21Myoglobinuria (HP:0002913)3.03617012
22Right ventricular cardiomyopathy (HP:0011663)3.01500139
23Nemaline bodies (HP:0003798)2.97420794
24Cerebral aneurysm (HP:0004944)2.95716086
25Ventricular tachycardia (HP:0004756)2.91825866
26Unilateral renal agenesis (HP:0000122)2.88412761
27Insomnia (HP:0100785)2.88353952
28Myositis (HP:0100614)2.88188713
29Cholecystitis (HP:0001082)2.85884780
30Abnormal gallbladder physiology (HP:0012438)2.85884780
31Abnormality of the lower motor neuron (HP:0002366)2.84682028
32Spontaneous hematomas (HP:0007420)2.83764164
33Lymphangioma (HP:0100764)2.83331687
34Upper limb amyotrophy (HP:0009129)2.81607703
35Distal upper limb amyotrophy (HP:0007149)2.81607703
36Prolonged bleeding time (HP:0003010)2.79630007
37Back pain (HP:0003418)2.76981988
38Reticulocytosis (HP:0001923)2.76251910
39Hyperacusis (HP:0010780)2.71871657
40Achilles tendon contracture (HP:0001771)2.69793075
41Protrusio acetabuli (HP:0003179)2.66725793
42Distal lower limb muscle weakness (HP:0009053)2.66559749
43Abnormality of the Achilles tendon (HP:0005109)2.65146967
44Gingivitis (HP:0000230)2.65135322
45Type 1 muscle fiber predominance (HP:0003803)2.64692461
46Distal lower limb amyotrophy (HP:0008944)2.64520808
47Shallow orbits (HP:0000586)2.63990158
48Bundle branch block (HP:0011710)2.63971645
49Orchitis (HP:0100796)2.61910122
50Hand muscle atrophy (HP:0009130)2.60848389
51Cellulitis (HP:0100658)2.59867503
52Increased variability in muscle fiber diameter (HP:0003557)2.56650276
53Recurrent gram-negative bacterial infections (HP:0005420)2.54445469
54Atrioventricular block (HP:0001678)2.51522030
55Poikilocytosis (HP:0004447)2.50497350
56Polycythemia (HP:0001901)2.50209904
57Urticaria (HP:0001025)2.45593788
58Rectal prolapse (HP:0002035)2.41005177
59Chronic obstructive pulmonary disease (HP:0006510)2.40724046
60Obstructive lung disease (HP:0006536)2.40724046
61Cholelithiasis (HP:0001081)2.40202856
62Abnormality of the fingertips (HP:0001211)2.39131927
63Alopecia of scalp (HP:0002293)2.38041822
64Chest pain (HP:0100749)2.37364701
65Asymmetric septal hypertrophy (HP:0001670)2.32201761
66Abnormality of skeletal muscle fiber size (HP:0012084)2.29534897
67Ependymoma (HP:0002888)2.28912892
68Increased IgE level (HP:0003212)2.27814355
69Abnormal delayed hypersensitivity skin test (HP:0002963)2.25995453
70Toxemia of pregnancy (HP:0100603)2.25664988
71Recurrent fungal infections (HP:0002841)2.23745805
72Gingival bleeding (HP:0000225)2.21061617
73Scapular winging (HP:0003691)2.21013827
74Dysmetric saccades (HP:0000641)2.18710709
75EMG: neuropathic changes (HP:0003445)2.18653162
76Abnormal hemoglobin (HP:0011902)2.17686322
77Epistaxis (HP:0000421)2.17405102
78Optic neuritis (HP:0100653)2.17291335
79Retrobulbar optic neuritis (HP:0100654)2.17291335
80Ankle contracture (HP:0006466)2.15421119
81Aneurysm (HP:0002617)2.15009774
82Elfin facies (HP:0004428)2.14248650
83Obstructive sleep apnea (HP:0002870)2.13347879
84Limb-girdle muscle atrophy (HP:0003797)2.12192258
85Genu recurvatum (HP:0002816)2.12149225
86Gastrointestinal inflammation (HP:0004386)2.11588633
87Foot dorsiflexor weakness (HP:0009027)2.11455107
88Abnormal atrioventricular conduction (HP:0005150)2.10699109
89Cerebral inclusion bodies (HP:0100314)2.10433947
90Rhabdomyolysis (HP:0003201)2.10165859
91Heart block (HP:0012722)2.10053195
92Mildly elevated creatine phosphokinase (HP:0008180)2.09475695
93EMG: myopathic abnormalities (HP:0003458)2.07964030
94Deep venous thrombosis (HP:0002625)2.07641065
95Peritonitis (HP:0002586)2.07447304
96Mediastinal lymphadenopathy (HP:0100721)2.06664826
97Subaortic stenosis (HP:0001682)2.05277936
98Abnormality of the left ventricular outflow tract (HP:0011103)2.05277936
99Elevated erythrocyte sedimentation rate (HP:0003565)2.05118756
100Premature rupture of membranes (HP:0001788)2.02898943
101Inflammation of the large intestine (HP:0002037)2.02860503
102Pseudobulbar signs (HP:0002200)2.02842043
103Abnormal gallbladder morphology (HP:0012437)2.02534675
104Abnormality of the gallbladder (HP:0005264)2.02032838
105Myopathic facies (HP:0002058)2.02002684
106Ventricular fibrillation (HP:0001663)1.99990812
107Meningitis (HP:0001287)1.98989248
108Gout (HP:0001997)1.98823234
109Broad metatarsal (HP:0001783)1.97896985
110Stomatitis (HP:0010280)1.97697541
111Abnormality of the foot musculature (HP:0001436)1.96979380
112Astrocytoma (HP:0009592)1.95181032
113Abnormality of the astrocytes (HP:0100707)1.95181032
114Ulnar bowing (HP:0003031)1.94832200
115Renal duplication (HP:0000075)1.93907059
116Enlarged penis (HP:0000040)1.93276426
117Renovascular hypertension (HP:0100817)1.92303265
118Abnormality of the calf musculature (HP:0001430)1.92227473
119Round ear (HP:0100830)1.91463214
120Fatigue (HP:0012378)1.90987396
121Bladder diverticulum (HP:0000015)1.90954629
122Recurrent skin infections (HP:0001581)1.89856456
123Ketoacidosis (HP:0001993)1.89818379
124Ankle clonus (HP:0011448)1.89505976
125Calf muscle hypertrophy (HP:0008981)1.88916915
126Easy fatigability (HP:0003388)1.87414391
127Pustule (HP:0200039)1.87100332
128Ketosis (HP:0001946)1.85216363
129Osteomyelitis (HP:0002754)1.83759664
130Mitral valve prolapse (HP:0001634)1.83719480
131Turricephaly (HP:0000262)1.82011636
132Ventricular arrhythmia (HP:0004308)1.81597622
133Ulnar deviation of the wrist (HP:0003049)1.81285279
134Termporal pattern (HP:0011008)1.80988383
135Insidious onset (HP:0003587)1.80988383
136Spinal rigidity (HP:0003306)1.80552972
137Frequent falls (HP:0002359)1.80252854
138Abnormal platelet volume (HP:0011876)1.79941560
139Decreased motor nerve conduction velocity (HP:0003431)1.78819441
140Male infertility (HP:0003251)1.77177382
141Vasculitis (HP:0002633)1.77133613
142Long toe (HP:0010511)1.76055629
143Global brain atrophy (HP:0002283)1.75921904
144Muscle fiber inclusion bodies (HP:0100299)1.75797600
145Muscle hypertrophy of the lower extremities (HP:0008968)1.74784015
146Neck muscle weakness (HP:0000467)1.74435382
147Hamartoma of the eye (HP:0010568)1.74097932
148Adenoma sebaceum (HP:0009720)1.73537509
149Angiofibromas (HP:0010615)1.73537509
150Broad face (HP:0000283)1.73437466
151Increased serum ferritin (HP:0003281)1.73313811
152Postural instability (HP:0002172)1.73158224
153Metaphyseal cupping (HP:0003021)1.72590978
154Arterial thrombosis (HP:0004420)1.72450832
155Lipoatrophy (HP:0100578)1.72393940
156Fibroma (HP:0010614)1.72312633
157Episodic fever (HP:0001954)1.71346899
158Bilateral sensorineural hearing impairment (HP:0008619)1.70947252
159Late onset (HP:0003584)1.70898913
160Rapidly progressive (HP:0003678)1.70723833
161Segmental peripheral demyelination/remyelination (HP:0003481)1.70622061
162Keratoconjunctivitis sicca (HP:0001097)1.70338030
163Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.70271253
164Follicular hyperkeratosis (HP:0007502)1.70121893
165Atrial fibrillation (HP:0005110)1.70074935
166Lower limb amyotrophy (HP:0007210)1.69313321
167Amyloidosis (HP:0011034)1.69149803
168Diaphragmatic weakness (HP:0009113)1.68534714
169Limb-girdle muscle weakness (HP:0003325)1.68222171
170Abnormality of iron homeostasis (HP:0011031)1.67682773
171Subacute progressive viral hepatitis (HP:0006572)1.67298940
172Muscle stiffness (HP:0003552)1.67146235
173Encephalitis (HP:0002383)1.67101778
174Colitis (HP:0002583)1.66405577

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.93162400
2PKN23.62299104
3PRPF4B3.15853233
4EEF2K3.04236171
5RIPK43.02791508
6TTN2.75274653
7LATS22.57842254
8CDK122.52014337
9ICK2.39541404
10MAP3K102.31112059
11SIK12.30316741
12LATS12.28709031
13GRK62.23736427
14TAOK22.22477140
15MAP3K32.22107041
16PRKD32.12174972
17MAP4K12.06319255
18NEK11.87955558
19RIPK11.84966839
20ERN11.82195480
21TAOK11.72482474
22PDK31.66055067
23PDK41.66055067
24PDGFRA1.66018395
25IRAK41.65130988
26PTK61.57377626
27SMG11.52972618
28MAP3K131.52209727
29FGR1.50576076
30FES1.47474223
31ZAP701.45003103
32SIK21.44104290
33CSK1.44103014
34LMTK21.43487186
35TYK21.42270734
36BLK1.40207751
37KSR21.39429063
38EPHA21.38791614
39PHKG11.37951636
40PHKG21.37951636
41PAK41.36302133
42ALK1.35566819
43TNK21.30904738
44TYRO31.27372187
45MTOR1.26037157
46DMPK1.25357103
47PAK61.22306769
48STK381.20549997
49SGK31.19747195
50MAPKAPK31.17961340
51NEK21.17247911
52JAK31.13637652
53BMX1.13335312
54IKBKE1.10203929
55BCKDK1.09755949
56MAP3K91.07824464
57MAP3K61.06925828
58HCK1.06014786
59CAMK1G1.03521571
60CAMK1D1.02529180
61MAP3K51.01022179
62TBK10.99483262
63SIK30.99312682
64MAPK120.93015049
65PTK20.90310944
66SYK0.89894159
67JAK20.88308420
68KSR10.88101726
69RET0.87804674
70BTK0.87162752
71MAP3K140.85972982
72DDR20.84890299
73MAP3K110.80315924
74PAK20.80259191
75PRKAA10.79555247
76LRRK20.79367282
77SGK20.77450139
78HIPK20.77080149
79IRAK30.77005740
80CDK40.76863625
81TESK10.76436969
82EIF2AK10.76261805
83MAP3K70.75397955
84IRAK20.73952835
85SCYL20.73264790
86PAK30.72987615
87MAP3K80.72365479
88STK38L0.71644448
89MAPK110.71280559
90EPHB10.70513134
91EPHB20.70386456
92STK40.68231290
93PDK10.67857141
94PIM10.67526748
95CDK60.67413453
96DYRK1B0.67184979
97MAP2K20.66115966
98STK30.65329581
99SGK4940.64950171
100SGK2230.64950171
101CAMK40.64346292
102FER0.62212931
103STK100.61976820
104PDK20.61730877
105RPS6KB20.60588329
106PIK3CG0.59143989
107CAMKK10.59141290
108MARK20.58733452
109CDC42BPA0.58616623
110FGFR30.58581115
111YES10.58117501
112DAPK20.58107916
113WNK40.57874941
114IRAK10.55497829
115NTRK10.54265356
116PRKD10.54254764
117PDGFRB0.54154294
118EPHA30.53942154
119MAP2K10.53483445
120WNK10.51773618
121CDK190.51730675
122JAK10.51158868
123RPS6KA20.50730432
124RAF10.50553915
125LYN0.49389745
126ERBB20.48233460
127RPS6KC10.47588970
128RPS6KL10.47588970
129STK110.46999757
130AKT20.46789783
131MAP2K30.46632826
132PTK2B0.46558163
133MAP3K20.45806111
134PRKCH0.45098401
135FGFR40.44839651
136MET0.44586011
137RPS6KA10.43985453
138CSNK1D0.43233119
139ILK0.43108529
140GRK50.42652809
141DYRK30.42388846
142PRKAA20.42029543
143CDC70.40807082
144MAPK70.40158710
145BRD40.39843758
146TTK0.39377836
147FGFR10.38387810
148FYN0.38183429
149FLT30.37759936
150PDPK10.37523978
151MARK30.37277080
152OBSCN0.35541630
153MAP3K10.32329483
154MAP2K40.32119072
155PRKD20.31697020
156TESK20.31663894

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.85455343
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.79535310
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.73275902
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.66302209
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.42308707
6Osteoclast differentiation_Homo sapiens_hsa043802.12875577
7B cell receptor signaling pathway_Homo sapiens_hsa046622.08106747
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.99890965
9Lysine degradation_Homo sapiens_hsa003101.87688263
10Fatty acid degradation_Homo sapiens_hsa000711.86563740
11Arginine biosynthesis_Homo sapiens_hsa002201.82367164
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.74867652
13Carbon metabolism_Homo sapiens_hsa012001.61500251
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57670832
15Leishmaniasis_Homo sapiens_hsa051401.56344595
16Biosynthesis of amino acids_Homo sapiens_hsa012301.50851225
17Malaria_Homo sapiens_hsa051441.48323813
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48194863
19Propanoate metabolism_Homo sapiens_hsa006401.45356401
20Insulin resistance_Homo sapiens_hsa049311.45336711
21Fatty acid metabolism_Homo sapiens_hsa012121.44561727
22AMPK signaling pathway_Homo sapiens_hsa041521.42535485
23Dilated cardiomyopathy_Homo sapiens_hsa054141.42513635
24PPAR signaling pathway_Homo sapiens_hsa033201.39259787
25T cell receptor signaling pathway_Homo sapiens_hsa046601.38577132
26mTOR signaling pathway_Homo sapiens_hsa041501.37080079
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36761598
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35589402
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.34720390
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33193530
31Bladder cancer_Homo sapiens_hsa052191.31785583
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.29997212
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.27644736
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.27565736
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.26555883
36Glucagon signaling pathway_Homo sapiens_hsa049221.26188698
37Fat digestion and absorption_Homo sapiens_hsa049751.25461364
38Tuberculosis_Homo sapiens_hsa051521.25302539
39Chemokine signaling pathway_Homo sapiens_hsa040621.23682649
40Insulin signaling pathway_Homo sapiens_hsa049101.23578531
41Pyruvate metabolism_Homo sapiens_hsa006201.23423015
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21215941
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20740304
44Bile secretion_Homo sapiens_hsa049761.20373259
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18112082
46Chronic myeloid leukemia_Homo sapiens_hsa052201.17953527
47Hepatitis B_Homo sapiens_hsa051611.17078805
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.17027989
49Hepatitis C_Homo sapiens_hsa051601.16943660
50Prolactin signaling pathway_Homo sapiens_hsa049171.15609831
51Dorso-ventral axis formation_Homo sapiens_hsa043201.12923898
52Adipocytokine signaling pathway_Homo sapiens_hsa049201.12896328
53GnRH signaling pathway_Homo sapiens_hsa049121.11757875
54Measles_Homo sapiens_hsa051621.11618066
55Toxoplasmosis_Homo sapiens_hsa051451.10987889
56Inositol phosphate metabolism_Homo sapiens_hsa005621.10811577
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09931028
58Focal adhesion_Homo sapiens_hsa045101.08848427
59Longevity regulating pathway - mammal_Homo sapiens_hsa042111.08510520
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08274973
61Renal cell carcinoma_Homo sapiens_hsa052111.08221742
62Butanoate metabolism_Homo sapiens_hsa006501.07188833
63NF-kappa B signaling pathway_Homo sapiens_hsa040641.07020315
64Influenza A_Homo sapiens_hsa051641.06839120
65Apoptosis_Homo sapiens_hsa042101.06197434
66Fatty acid biosynthesis_Homo sapiens_hsa000611.06018513
67Platelet activation_Homo sapiens_hsa046111.05588502
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05183010
69Adherens junction_Homo sapiens_hsa045201.04853931
70Choline metabolism in cancer_Homo sapiens_hsa052311.04849875
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.04725585
72Type II diabetes mellitus_Homo sapiens_hsa049301.04601676
73TNF signaling pathway_Homo sapiens_hsa046681.04343604
74Jak-STAT signaling pathway_Homo sapiens_hsa046301.02735493
75Tryptophan metabolism_Homo sapiens_hsa003801.02511748
76VEGF signaling pathway_Homo sapiens_hsa043701.02043033
77Tight junction_Homo sapiens_hsa045301.00568044
78Phospholipase D signaling pathway_Homo sapiens_hsa040721.00259342
79Glioma_Homo sapiens_hsa052141.00194247
80Other glycan degradation_Homo sapiens_hsa005110.99316332
81Hippo signaling pathway_Homo sapiens_hsa043900.99053607
82Shigellosis_Homo sapiens_hsa051310.97610672
83Long-term potentiation_Homo sapiens_hsa047200.97011965
84Endometrial cancer_Homo sapiens_hsa052130.96728119
85Selenocompound metabolism_Homo sapiens_hsa004500.96389603
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96024522
87Non-small cell lung cancer_Homo sapiens_hsa052230.95237858
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90966770
89Estrogen signaling pathway_Homo sapiens_hsa049150.90856909
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90113406
91Notch signaling pathway_Homo sapiens_hsa043300.88953921
92Proteoglycans in cancer_Homo sapiens_hsa052050.88816074
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88262243
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.88040506
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86992208
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84439134
97Prostate cancer_Homo sapiens_hsa052150.84151983
98Herpes simplex infection_Homo sapiens_hsa051680.81877917
99Colorectal cancer_Homo sapiens_hsa052100.80005828
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79987045
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.79492951
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78802313
103Fructose and mannose metabolism_Homo sapiens_hsa000510.78785448
104Legionellosis_Homo sapiens_hsa051340.77807659
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77527471
106Small cell lung cancer_Homo sapiens_hsa052220.77346317
107Glycerolipid metabolism_Homo sapiens_hsa005610.76969417
108Salmonella infection_Homo sapiens_hsa051320.76934589
109ECM-receptor interaction_Homo sapiens_hsa045120.75478767
110Viral myocarditis_Homo sapiens_hsa054160.74375462
111MAPK signaling pathway_Homo sapiens_hsa040100.74354673
112Amoebiasis_Homo sapiens_hsa051460.74212819
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73934540
114Phagosome_Homo sapiens_hsa041450.72210769
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71223455
116African trypanosomiasis_Homo sapiens_hsa051430.70999546
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70903619
118MicroRNAs in cancer_Homo sapiens_hsa052060.69792435
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69629931
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69611827
121Staphylococcus aureus infection_Homo sapiens_hsa051500.69391995
122Protein digestion and absorption_Homo sapiens_hsa049740.69162249
123Basal cell carcinoma_Homo sapiens_hsa052170.68272333
124HIF-1 signaling pathway_Homo sapiens_hsa040660.65716907
125Hematopoietic cell lineage_Homo sapiens_hsa046400.65294748
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64751154
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64323758
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63205223
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.62081151
130Pentose phosphate pathway_Homo sapiens_hsa000300.60715771
131Hedgehog signaling pathway_Homo sapiens_hsa043400.60461401
132HTLV-I infection_Homo sapiens_hsa051660.60229000
133Starch and sucrose metabolism_Homo sapiens_hsa005000.59688628
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59425163
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.57625868
136Sulfur relay system_Homo sapiens_hsa041220.57115973
137Viral carcinogenesis_Homo sapiens_hsa052030.57014976
138Primary bile acid biosynthesis_Homo sapiens_hsa001200.56496244
139Primary immunodeficiency_Homo sapiens_hsa053400.55715759
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55680490
141Gastric acid secretion_Homo sapiens_hsa049710.54272327
142Gap junction_Homo sapiens_hsa045400.53960390
143Pancreatic cancer_Homo sapiens_hsa052120.53854661
144Regulation of autophagy_Homo sapiens_hsa041400.53393275
145Acute myeloid leukemia_Homo sapiens_hsa052210.52247010
146Vitamin B6 metabolism_Homo sapiens_hsa007500.51327924
147Thyroid cancer_Homo sapiens_hsa052160.51295202
148ErbB signaling pathway_Homo sapiens_hsa040120.51248836
149beta-Alanine metabolism_Homo sapiens_hsa004100.50682152
150Oxytocin signaling pathway_Homo sapiens_hsa049210.49019923
151Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48050482
152Oocyte meiosis_Homo sapiens_hsa041140.47138393
153FoxO signaling pathway_Homo sapiens_hsa040680.46451653
154Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46274774
155Arginine and proline metabolism_Homo sapiens_hsa003300.46063894
156Endocytosis_Homo sapiens_hsa041440.45873627
157Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45430088
158Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45181049

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »