RNF103

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.26319035
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.26319035
3L-phenylalanine metabolic process (GO:0006558)5.82829027
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.82829027
5aromatic amino acid family catabolic process (GO:0009074)5.51573738
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.34435924
7bile acid biosynthetic process (GO:0006699)5.00452696
8alpha-linolenic acid metabolic process (GO:0036109)4.86074016
9tryptophan catabolic process (GO:0006569)4.84814663
10indole-containing compound catabolic process (GO:0042436)4.84814663
11indolalkylamine catabolic process (GO:0046218)4.84814663
12kynurenine metabolic process (GO:0070189)4.75950590
13high-density lipoprotein particle remodeling (GO:0034375)4.61391389
14tryptophan metabolic process (GO:0006568)4.59051826
15urea cycle (GO:0000050)4.52903126
16urea metabolic process (GO:0019627)4.52903126
17glyoxylate metabolic process (GO:0046487)4.46753337
18peptidyl-glutamic acid carboxylation (GO:0017187)4.42393123
19protein carboxylation (GO:0018214)4.42393123
20complement activation, alternative pathway (GO:0006957)4.42295924
21sulfur amino acid catabolic process (GO:0000098)4.38991073
22negative regulation of fibrinolysis (GO:0051918)4.36842671
23regulation of triglyceride catabolic process (GO:0010896)4.36249058
24bile acid metabolic process (GO:0008206)4.35767607
25regulation of protein activation cascade (GO:2000257)4.30031873
26cysteine metabolic process (GO:0006534)4.28029374
27regulation of fibrinolysis (GO:0051917)4.26585319
28reverse cholesterol transport (GO:0043691)4.20216399
29nitrogen cycle metabolic process (GO:0071941)4.15330233
30protein-lipid complex remodeling (GO:0034368)4.08324973
31macromolecular complex remodeling (GO:0034367)4.08324973
32plasma lipoprotein particle remodeling (GO:0034369)4.08324973
33regulation of cholesterol esterification (GO:0010872)4.07245457
34regulation of complement activation (GO:0030449)4.02405498
35phospholipid efflux (GO:0033700)4.01196291
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.99327759
37cellular ketone body metabolic process (GO:0046950)3.98382722
38tyrosine metabolic process (GO:0006570)3.97064307
39aromatic amino acid family metabolic process (GO:0009072)3.93038789
40homocysteine metabolic process (GO:0050667)3.90500317
41acylglycerol homeostasis (GO:0055090)3.86442434
42triglyceride homeostasis (GO:0070328)3.86442434
43bile acid and bile salt transport (GO:0015721)3.85094612
44glutamate metabolic process (GO:0006536)3.85022177
45cholesterol efflux (GO:0033344)3.78643359
46serine family amino acid catabolic process (GO:0009071)3.74948206
47alpha-amino acid catabolic process (GO:1901606)3.74633094
48plasma lipoprotein particle clearance (GO:0034381)3.73857155
49negative regulation of cholesterol transport (GO:0032375)3.72825263
50negative regulation of sterol transport (GO:0032372)3.72825263
51cellular glucuronidation (GO:0052695)3.71744879
52dicarboxylic acid biosynthetic process (GO:0043650)3.70087438
53lysine metabolic process (GO:0006553)3.67879611
54lysine catabolic process (GO:0006554)3.67879611
55coenzyme catabolic process (GO:0009109)3.65000204
56low-density lipoprotein particle remodeling (GO:0034374)3.54055896
57drug catabolic process (GO:0042737)3.51531545
58cellular amino acid catabolic process (GO:0009063)3.48950723
59indolalkylamine metabolic process (GO:0006586)3.48631831
60ketone body metabolic process (GO:1902224)3.44907801
61amino-acid betaine metabolic process (GO:0006577)3.43895050
62cellular modified amino acid catabolic process (GO:0042219)3.43321178
63benzene-containing compound metabolic process (GO:0042537)3.42898306
64plasma lipoprotein particle assembly (GO:0034377)3.40912558
65uronic acid metabolic process (GO:0006063)3.36940352
66glucuronate metabolic process (GO:0019585)3.36940352
67regulation of bile acid biosynthetic process (GO:0070857)3.35217771
68regulation of cholesterol homeostasis (GO:2000188)3.33906589
69phospholipid homeostasis (GO:0055091)3.31846698
70short-chain fatty acid metabolic process (GO:0046459)3.30575753
71positive regulation of lipid catabolic process (GO:0050996)3.29684369
72amine catabolic process (GO:0009310)3.28676621
73cellular biogenic amine catabolic process (GO:0042402)3.28676621
74fibrinolysis (GO:0042730)3.25561199
75negative regulation of lipase activity (GO:0060192)3.24846232
76ethanol oxidation (GO:0006069)3.22608631
77macroautophagy (GO:0016236)3.18946543
78plasma lipoprotein particle organization (GO:0071827)3.16366920
79arginine metabolic process (GO:0006525)3.15397978
80protein-lipid complex assembly (GO:0065005)3.13840468
81very-low-density lipoprotein particle assembly (GO:0034379)3.13184054
82drug transmembrane transport (GO:0006855)3.11971128
83positive regulation of triglyceride lipase activity (GO:0061365)3.11483104
84positive regulation of lipoprotein lipase activity (GO:0051006)3.11483104
85cholesterol homeostasis (GO:0042632)3.08569686
86sterol homeostasis (GO:0055092)3.07732096
87opsonization (GO:0008228)3.07301806
88cofactor catabolic process (GO:0051187)3.06801197
89carboxylic acid catabolic process (GO:0046395)3.03722472
90organic acid catabolic process (GO:0016054)3.03722472
91imidazole-containing compound metabolic process (GO:0052803)3.03484707
92lipoprotein metabolic process (GO:0042157)3.03354172
93acetyl-CoA metabolic process (GO:0006084)3.02882616
94complement activation, classical pathway (GO:0006958)3.02525182
95protein-lipid complex subunit organization (GO:0071825)3.02231232
96exogenous drug catabolic process (GO:0042738)3.01115757
97complement activation (GO:0006956)3.00797446
98intestinal cholesterol absorption (GO:0030299)2.99626287
99cytolysis (GO:0019835)2.98394656
100flavonoid metabolic process (GO:0009812)2.96743140
101protein activation cascade (GO:0072376)2.95476280
102epoxygenase P450 pathway (GO:0019373)2.90902280
103negative regulation of protein activation cascade (GO:2000258)2.73557910
104nerve growth factor signaling pathway (GO:0038180)2.67582706
105negative regulation of complement activation (GO:0045916)2.64047696
106cellular response to ethanol (GO:0071361)2.60349850
107carnitine shuttle (GO:0006853)2.33549836
108amino-acid betaine transport (GO:0015838)2.30954979
109carnitine transport (GO:0015879)2.30954979
110regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.28352204
111negative regulation of humoral immune response (GO:0002921)2.27633206
112carnitine transmembrane transport (GO:1902603)2.25551457
113positive regulation of fatty acid beta-oxidation (GO:0032000)2.23453306
114positive regulation of Rap GTPase activity (GO:0032854)2.19318013
115omega-hydroxylase P450 pathway (GO:0097267)2.18128939
116regulation of ARF protein signal transduction (GO:0032012)2.16696008
117negative regulation of fatty acid transport (GO:2000192)2.06571044
118quaternary ammonium group transport (GO:0015697)2.04747388
119histone H3-K36 demethylation (GO:0070544)2.03213697
120fatty acid transmembrane transport (GO:1902001)2.02351536
121ethanol metabolic process (GO:0006067)2.01433980
122retrograde transport, vesicle recycling within Golgi (GO:0000301)1.99955565
123intestinal absorption (GO:0050892)1.99893384
124regulation of energy homeostasis (GO:2000505)1.97152579
125positive regulation of fatty acid oxidation (GO:0046321)1.96934036
126mannose metabolic process (GO:0006013)1.93633697
127establishment of protein localization to Golgi (GO:0072600)1.91713114
128Rap protein signal transduction (GO:0032486)1.90633018
129alkaloid metabolic process (GO:0009820)1.90295620
130insulin-like growth factor receptor signaling pathway (GO:0048009)1.90268565
131negative regulation of neurotransmitter secretion (GO:0046929)1.88508256
132protein targeting to Golgi (GO:0000042)1.87530997
133regulation of Rap GTPase activity (GO:0032317)1.87084756
134germinal center formation (GO:0002467)1.86988446
135phospholipid translocation (GO:0045332)1.86848794
136lipid translocation (GO:0034204)1.86848794
137positive regulation of extracellular matrix organization (GO:1903055)1.86753631
138acute-phase response (GO:0006953)1.86099047
139phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)1.85955878
140embryonic retina morphogenesis in camera-type eye (GO:0060059)1.84795671
141positive regulation of glycolytic process (GO:0045821)1.84364095
142regulation of toll-like receptor 4 signaling pathway (GO:0034143)1.84081247
143response to nerve growth factor (GO:1990089)1.81614404
144cellular response to nerve growth factor stimulus (GO:1990090)1.81614404
145growth hormone receptor signaling pathway (GO:0060396)1.81338077
146sodium ion homeostasis (GO:0055078)1.80731708
147striated muscle atrophy (GO:0014891)1.79319963
148Golgi to endosome transport (GO:0006895)1.78779423
149drug metabolic process (GO:0017144)1.78622305
150negative regulation of inclusion body assembly (GO:0090084)1.78471171
151lipoprotein transport (GO:0042953)1.76590272
152cell communication by electrical coupling involved in cardiac conduction (GO:0086064)1.74308013
153cellular response to epinephrine stimulus (GO:0071872)1.74134331
154regulation of lipid catabolic process (GO:0050994)1.73636784
155diacylglycerol metabolic process (GO:0046339)1.73470746
156regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)1.73174488
157interleukin-6-mediated signaling pathway (GO:0070102)1.72095944
158negative regulation of lipid transport (GO:0032369)1.71019784
159regulation of humoral immune response (GO:0002920)1.70500371
160maintenance of gastrointestinal epithelium (GO:0030277)1.70275751
161negative regulation of hemostasis (GO:1900047)1.70199279
162negative regulation of blood coagulation (GO:0030195)1.70199279
163negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)1.69652342
164relaxation of cardiac muscle (GO:0055119)1.69637989
165skeletal muscle adaptation (GO:0043501)1.69239271
166regulation of fatty acid beta-oxidation (GO:0031998)1.67692542
167negative regulation of immunoglobulin mediated immune response (GO:0002890)1.67025177
168negative regulation of B cell mediated immunity (GO:0002713)1.67025177
169negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)1.66633769
170pyrimidine-containing compound transmembrane transport (GO:0072531)1.66632875
171regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)1.66015567
172cellular response to fluid shear stress (GO:0071498)1.65786605

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.34916423
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.34838850
3* LXR_22158963_ChIP-Seq_LIVER_Mouse4.45606630
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.42023108
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.11916059
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.61038228
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.94582909
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.79948367
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.56747410
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.23747446
11IRF8_22096565_ChIP-ChIP_GC-B_Human1.93008655
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.87716368
13SMAD_19615063_ChIP-ChIP_OVARY_Human1.85006990
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.59635406
15* FOXA2_19822575_ChIP-Seq_HepG2_Human1.58455465
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49900318
17GATA1_22025678_ChIP-Seq_K562_Human1.49460369
18GBX2_23144817_ChIP-Seq_PC3_Human1.49283525
19* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42155580
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.37091861
21NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32783392
22NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32783392
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30694180
24BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29787055
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27552307
26CLOCK_20551151_ChIP-Seq_293T_Human1.27294588
27GATA2_21666600_ChIP-Seq_HMVEC_Human1.26497552
28VDR_24787735_ChIP-Seq_THP-1_Human1.25728689
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.25585772
30RUNX_20019798_ChIP-Seq_JUKART_Human1.24970525
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24765218
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.20180368
33TAF15_26573619_Chip-Seq_HEK293_Human1.19285417
34ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17377302
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.16950982
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16472322
37CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15674710
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13472297
39STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13463858
40HTT_18923047_ChIP-ChIP_STHdh_Human1.12111318
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.12052697
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11217481
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10009702
44BCAT_22108803_ChIP-Seq_LS180_Human1.09006851
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08702884
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08317082
47ER_23166858_ChIP-Seq_MCF-7_Human1.08139815
48TP53_16413492_ChIP-PET_HCT116_Human1.07316930
49HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06775116
50* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06253228
51* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05942279
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.05126476
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03852350
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03650148
55CJUN_26792858_Chip-Seq_BT549_Human1.02210396
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01540080
57* HNF4A_19822575_ChIP-Seq_HepG2_Human1.00603692
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00323449
59IGF1R_20145208_ChIP-Seq_DFB_Human1.00063897
60FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99629323
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98175297
62BP1_19119308_ChIP-ChIP_Hs578T_Human0.97822145
63DROSHA_22980978_ChIP-Seq_HELA_Human0.96602184
64SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95061665
65* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94893541
66AR_21572438_ChIP-Seq_LNCaP_Human0.93893466
67SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92962125
68WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92557578
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92557075
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91810031
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90620752
72CDX2_22108803_ChIP-Seq_LS180_Human0.90458836
73SOX2_20726797_ChIP-Seq_SW620_Human0.89648646
74* TCF4_18268006_ChIP-ChIP_LS174T_Human0.89376815
75EZH2_18974828_ChIP-Seq_MESCs_Mouse0.89212329
76RNF2_18974828_ChIP-Seq_MESCs_Mouse0.89212329
77FOXO3_23340844_ChIP-Seq_DLD1_Human0.88620763
78SMAD4_21799915_ChIP-Seq_A2780_Human0.87966195
79GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87468088
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87364983
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86501561
82AHR_22903824_ChIP-Seq_MCF-7_Human0.85520003
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84090744
84* IRF8_27001747_Chip-Seq_BMDM_Mouse0.83870492
85PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83712104
86CDX2_20551321_ChIP-Seq_CACO-2_Human0.83701857
87RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83408500
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83405426
89NR3C1_23031785_ChIP-Seq_PC12_Mouse0.83268501
90PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82835353
91SOX9_24532713_ChIP-Seq_HFSC_Mouse0.82726249
92* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.82710771
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82583098
94GATA1_19941826_ChIP-Seq_K562_Human0.82489019
95P300_19829295_ChIP-Seq_ESCs_Human0.82305207
96ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82053919
97ESR1_21235772_ChIP-Seq_MCF-7_Human0.81915302
98TCF4_23295773_ChIP-Seq_U87_Human0.81161632
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80785696
100GATA2_19941826_ChIP-Seq_K562_Human0.80755870
101ARNT_22903824_ChIP-Seq_MCF-7_Human0.80718907
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80346588
103SMAD3_21741376_ChIP-Seq_HESCs_Human0.80192275
104EED_16625203_ChIP-ChIP_MESCs_Mouse0.78375680
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77600060
106SOX2_21211035_ChIP-Seq_LN229_Gbm0.76868688
107TP53_18474530_ChIP-ChIP_U2OS_Human0.76805752
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.76674098
109FOXA1_25552417_ChIP-Seq_VCAP_Human0.76417204
110NR3C1_21868756_ChIP-Seq_MCF10A_Human0.76084144
111RXR_22108803_ChIP-Seq_LS180_Human0.75783907
112PPAR_26484153_Chip-Seq_NCI-H1993_Human0.75716752
113AR_25329375_ChIP-Seq_VCAP_Human0.75629156
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75397053
115GATA4_25053715_ChIP-Seq_YYC3_Human0.75327547
116SMAD4_21741376_ChIP-Seq_HESCs_Human0.74776394
117JARID2_20075857_ChIP-Seq_MESCs_Mouse0.74675291
118SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74168423
119EP300_21415370_ChIP-Seq_HL-1_Mouse0.73676409
120TP63_23658742_ChIP-Seq_EP156T_Human0.73455223
121CTBP2_25329375_ChIP-Seq_LNCAP_Human0.73385578
122PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.73314637
123EZH2_27294783_Chip-Seq_ESCs_Mouse0.73137946
124ZFP57_27257070_Chip-Seq_ESCs_Mouse0.72689515
125SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.72282779
126JARID2_20064375_ChIP-Seq_MESCs_Mouse0.72031295
127POU3F2_20337985_ChIP-ChIP_501MEL_Human0.72007329
128FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.71563394
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.71407757
130SUZ12_27294783_Chip-Seq_ESCs_Mouse0.71083052
131RARG_19884340_ChIP-ChIP_MEFs_Mouse0.70954159
132STAT3_23295773_ChIP-Seq_U87_Human0.70847458
133SMAD3_21741376_ChIP-Seq_EPCs_Human0.70661977
134FOXM1_26456572_ChIP-Seq_MCF-7_Human0.70002190
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.68919638
136EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.68090947
137* SMAD4_21741376_ChIP-Seq_EPCs_Human0.68059246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.39371193
2MP0005360_urolithiasis6.75765739
3MP0005085_abnormal_gallbladder_physiolo5.86813790
4MP0005365_abnormal_bile_salt5.48072273
5MP0008875_abnormal_xenobiotic_pharmacok4.63054086
6MP0003252_abnormal_bile_duct3.71175559
7MP0010329_abnormal_lipoprotein_level3.24542777
8MP0003806_abnormal_nucleotide_metabolis2.95007221
9MP0003195_calcinosis2.76547738
10MP0009840_abnormal_foam_cell2.71004629
11MP0001666_abnormal_nutrient_absorption2.69692141
12MP0005083_abnormal_biliary_tract2.67317339
13MP0005332_abnormal_amino_acid2.51896043
14MP0003191_abnormal_cellular_cholesterol2.26503187
15MP0003183_abnormal_peptide_metabolism2.16097174
16MP0002118_abnormal_lipid_homeostasis2.06345511
17MP0004019_abnormal_vitamin_homeostasis1.95165063
18MP0003868_abnormal_feces_composition1.94967812
19MP0002138_abnormal_hepatobiliary_system1.83834432
20MP0000609_abnormal_liver_physiology1.83334854
21MP0003045_fibrosis1.75925932
22MP0005409_darkened_coat_color1.75193885
23MP0002009_preneoplasia1.70671532
24MP0003303_peritoneal_inflammation1.69171863
25MP0004484_altered_response_of1.68926901
26MP0003828_pulmonary_edema1.56028659
27MP0000604_amyloidosis1.53696780
28MP0005584_abnormal_enzyme/coenzyme_acti1.49724470
29MP0005319_abnormal_enzyme/_coenzyme1.47341516
30MP0004084_abnormal_cardiac_muscle1.42042113
31MP0002822_catalepsy1.39224426
32MP0003436_decreased_susceptibility_to1.38061090
33MP0003329_amyloid_beta_deposits1.34946158
34MP0004036_abnormal_muscle_relaxation1.34345012
35MP0005670_abnormal_white_adipose1.32786323
36MP0003879_abnormal_hair_cell1.29885454
37MP0004510_myositis1.28281478
38MP0003690_abnormal_glial_cell1.27798758
39MP0003866_abnormal_defecation1.24606278
40MP0008004_abnormal_stomach_pH1.23482339
41MP0001502_abnormal_circadian_rhythm1.21214239
42MP0004264_abnormal_extraembryonic_tissu1.20981584
43MP0003172_abnormal_lysosome_physiology1.20894314
44MP0010155_abnormal_intestine_physiology1.19080226
45MP0002166_altered_tumor_susceptibility1.18350505
46MP0009643_abnormal_urine_homeostasis1.15499649
47MP0009780_abnormal_chondrocyte_physiolo1.14321414
48MP0001764_abnormal_homeostasis1.14111383
49MP0005451_abnormal_body_composition1.11998464
50MP0002254_reproductive_system_inflammat1.10462364
51MP0004130_abnormal_muscle_cell1.09234163
52MP0002998_abnormal_bone_remodeling1.08503230
53MP0009764_decreased_sensitivity_to1.08298473
54MP0001664_abnormal_digestion1.05941350
55MP0009697_abnormal_copulation1.05753575
56MP0009115_abnormal_fat_cell1.02987373
57MP0001851_eye_inflammation1.02068009
58MP0005535_abnormal_body_temperature1.01658626
59MP0003705_abnormal_hypodermis_morpholog1.01552284
60MP0002876_abnormal_thyroid_physiology0.99603456
61MP0006138_congestive_heart_failure0.99084662
62MP0010234_abnormal_vibrissa_follicle0.96999587
63MP0004215_abnormal_myocardial_fiber0.95642007
64MP0005084_abnormal_gallbladder_morpholo0.91869707
65MP0002078_abnormal_glucose_homeostasis0.91540727
66MP0003656_abnormal_erythrocyte_physiolo0.91169100
67MP0003075_altered_response_to0.89888859
68MP0004270_analgesia0.89443416
69MP0002837_dystrophic_cardiac_calcinosis0.88807509
70MP0005636_abnormal_mineral_homeostasis0.88071103
71MP0005647_abnormal_sex_gland0.88062065
72MP0003091_abnormal_cell_migration0.86604840
73MP0000249_abnormal_blood_vessel0.86322961
74MP0005167_abnormal_blood-brain_barrier0.84557701
75MP0000465_gastrointestinal_hemorrhage0.84240735
76MP0002638_abnormal_pupillary_reflex0.81160863
77MP0005166_decreased_susceptibility_to0.79916695
78MP0005334_abnormal_fat_pad0.79910449
79MP0004043_abnormal_pH_regulation0.79679013
80MP0005310_abnormal_salivary_gland0.79380918
81MP0002909_abnormal_adrenal_gland0.79278582
82MP0001533_abnormal_skeleton_physiology0.79215778
83MP0002971_abnormal_brown_adipose0.78570697
84MP0009642_abnormal_blood_homeostasis0.78551342
85MP0005448_abnormal_energy_balance0.77872612
86MP0000598_abnormal_liver_morphology0.77700709
87MP0004947_skin_inflammation0.77042728
88MP0005408_hypopigmentation0.76953336
89MP0009763_increased_sensitivity_to0.76515355
90MP0005423_abnormal_somatic_nervous0.74497848
91MP0001440_abnormal_grooming_behavior0.73743938
92MP0003300_gastrointestinal_ulcer0.73402833
93MP0002090_abnormal_vision0.73208839
94MP0005620_abnormal_muscle_contractility0.72608483
95MP0010368_abnormal_lymphatic_system0.71977346
96MP0002332_abnormal_exercise_endurance0.71540829
97MP0001756_abnormal_urination0.70776319
98MP0003011_delayed_dark_adaptation0.69721129
99MP0009785_altered_susceptibility_to0.69658683
100MP0008469_abnormal_protein_level0.69370497
101MP0008569_lethality_at_weaning0.67598925
102MP0000920_abnormal_myelination0.67585101
103MP0009384_cardiac_valve_regurgitation0.67393100
104MP0005058_abnormal_lysosome_morphology0.66969543
105MP0010678_abnormal_skin_adnexa0.66207458
106MP0008874_decreased_physiological_sensi0.66093628
107MP0001800_abnormal_humoral_immune0.65959949
108MP0009765_abnormal_xenobiotic_induced0.62798739
109MP0003633_abnormal_nervous_system0.62641093
110MP0005220_abnormal_exocrine_pancreas0.61668374
111MP0000639_abnormal_adrenal_gland0.61631307
112MP0005248_abnormal_Harderian_gland0.60999500
113MP0000230_abnormal_systemic_arterial0.58633798
114MP0001765_abnormal_ion_homeostasis0.57345574
115MP0001984_abnormal_olfaction0.57178625
116MP0005376_homeostasis/metabolism_phenot0.55221459
117MP0003186_abnormal_redox_activity0.55191419
118MP0003638_abnormal_response/metabolism_0.54932534
119MP0004885_abnormal_endolymph0.53755322
120MP0001501_abnormal_sleep_pattern0.52671325
121MP0003953_abnormal_hormone_level0.52186103
122MP0001661_extended_life_span0.50564716
123MP0004859_abnormal_synaptic_plasticity0.50391538
124MP0005187_abnormal_penis_morphology0.49514209
125MP0002168_other_aberrant_phenotype0.49445502
126MP0004883_abnormal_blood_vessel0.48174208
127MP0006082_CNS_inflammation0.47302784
128MP0009745_abnormal_behavioral_response0.46248883
129MP0003631_nervous_system_phenotype0.46138873
130MP0002896_abnormal_bone_mineralization0.44807619
131MP0005164_abnormal_response_to0.44014901
132MP0002928_abnormal_bile_duct0.43795346
133MP0002064_seizures0.43526380
134MP0002295_abnormal_pulmonary_circulatio0.43152914
135MP0003632_abnormal_nervous_system0.42921071
136MP0004782_abnormal_surfactant_physiolog0.42203295
137MP0008961_abnormal_basal_metabolism0.41878038
138MP0000579_abnormal_nail_morphology0.41814385
139* MP0003635_abnormal_synaptic_transmissio0.40993005
140MP0003724_increased_susceptibility_to0.40962911
141MP0002136_abnormal_kidney_physiology0.40546663

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.59661070
2Deep venous thrombosis (HP:0002625)6.50655351
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.30784375
4Xanthomatosis (HP:0000991)5.69954357
5Prolonged partial thromboplastin time (HP:0003645)5.64201540
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.54495817
7Hypobetalipoproteinemia (HP:0003563)5.27463932
8Complement deficiency (HP:0004431)5.04842874
9Hyperlipoproteinemia (HP:0010980)4.87479987
10Abnormality of the common coagulation pathway (HP:0010990)4.16989446
11Epidermoid cyst (HP:0200040)4.12736835
12Hypolipoproteinemia (HP:0010981)4.05664569
13Fat malabsorption (HP:0002630)3.99566035
14Conjugated hyperbilirubinemia (HP:0002908)3.97816626
15Abnormality of glutamine family amino acid metabolism (HP:0010902)3.94896622
16Joint hemorrhage (HP:0005261)3.90167023
17Hyperammonemia (HP:0001987)3.83450511
18Ketosis (HP:0001946)3.80581387
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.74798403
20Hypoalphalipoproteinemia (HP:0003233)3.66245583
21Hypoglycemic coma (HP:0001325)3.63433526
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.59562649
23Abnormality of complement system (HP:0005339)3.53495607
24Hyperglycinemia (HP:0002154)3.48287519
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.43040601
26Abnormality of methionine metabolism (HP:0010901)3.39897580
27Abnormality of the intrinsic pathway (HP:0010989)3.37030946
28Hypercholesterolemia (HP:0003124)3.21324436
29Myocardial infarction (HP:0001658)3.13112571
30Abnormality of serine family amino acid metabolism (HP:0010894)3.11813173
31Abnormality of glycine metabolism (HP:0010895)3.11813173
32Hyperglycinuria (HP:0003108)3.11054388
33Ketoacidosis (HP:0001993)2.98767628
34Febrile seizures (HP:0002373)2.98275186
35Steatorrhea (HP:0002570)2.94916933
36Papilledema (HP:0001085)2.84112357
37Systemic lupus erythematosus (HP:0002725)2.79453780
38Hypoglycemic seizures (HP:0002173)2.76153223
39Skin nodule (HP:0200036)2.75786486
40Hyperbilirubinemia (HP:0002904)2.75654393
41Abnormality of fatty-acid metabolism (HP:0004359)2.73433442
42Spontaneous abortion (HP:0005268)2.72491121
43Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.70670367
44Hyporeflexia of lower limbs (HP:0002600)2.69679976
45Hepatocellular carcinoma (HP:0001402)2.65562743
46Glomerulonephritis (HP:0000099)2.57626196
47Abnormality of purine metabolism (HP:0004352)2.54665174
48Delayed CNS myelination (HP:0002188)2.45689509
49Hypochromic microcytic anemia (HP:0004840)2.43683049
50Decreased circulating renin level (HP:0003351)2.42823272
51Amyloidosis (HP:0011034)2.41645777
52Abnormality of nucleobase metabolism (HP:0010932)2.40232067
53Vascular calcification (HP:0004934)2.37041978
54Metabolic acidosis (HP:0001942)2.36810526
55Acanthocytosis (HP:0001927)2.36516291
56Sensorimotor neuropathy (HP:0007141)2.34751116
57Hyperkalemia (HP:0002153)2.34231618
58Mitral stenosis (HP:0001718)2.31896912
59Hyperinsulinemic hypoglycemia (HP:0000825)2.30028210
60Abnormality of serum amino acid levels (HP:0003112)2.29730409
61Neurofibrillary tangles (HP:0002185)2.29477280
62Bundle branch block (HP:0011710)2.28036230
63Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.27893620
64Gout (HP:0001997)2.27659204
65Papillary thyroid carcinoma (HP:0002895)2.25402778
66Ventricular fibrillation (HP:0001663)2.25366362
67Exercise-induced myalgia (HP:0003738)2.24562175
68Esophageal varix (HP:0002040)2.17992857
69Recurrent gram-negative bacterial infections (HP:0005420)2.17890164
70Syncope (HP:0001279)2.17886540
71Hydroxyprolinuria (HP:0003080)2.17879470
72Abnormality of proline metabolism (HP:0010907)2.17879470
73Cardiovascular calcification (HP:0011915)2.17805092
74Hypophosphatemic rickets (HP:0004912)2.16624607
75Irritability (HP:0000737)2.14891301
76Metabolic alkalosis (HP:0200114)2.14848990
77Aortic aneurysm (HP:0004942)2.14387547
78Abnormal gallbladder morphology (HP:0012437)2.13652503
79Right ventricular cardiomyopathy (HP:0011663)2.12904338
80Abnormality of pyrimidine metabolism (HP:0004353)2.11365855
81Ankle clonus (HP:0011448)2.07495016
82Eczematoid dermatitis (HP:0000976)2.05342465
83Cerebral inclusion bodies (HP:0100314)2.05215394
84Hyperactive renin-angiotensin system (HP:0000841)2.02430933
85Asymmetric septal hypertrophy (HP:0001670)2.01664274
86Malnutrition (HP:0004395)1.99565886
87Lethargy (HP:0001254)1.99085547
88Postural instability (HP:0002172)1.98958414
89Cholecystitis (HP:0001082)1.98531828
90Abnormal gallbladder physiology (HP:0012438)1.98531828
91Hemorrhage of the eye (HP:0011885)1.98463356
92Neonatal onset (HP:0003623)1.98043486
93Rickets (HP:0002748)1.97861312
94Cholelithiasis (HP:0001081)1.97228609
95Status epilepticus (HP:0002133)1.94698355
96Spastic diplegia (HP:0001264)1.94026152
97Abnormality of renin-angiotensin system (HP:0000847)1.93583647
98Symptomatic seizures (HP:0011145)1.92973713
99Confusion (HP:0001289)1.92879055
100Pigmentary retinal degeneration (HP:0001146)1.92597937
101Pancreatitis (HP:0001733)1.92330897
102Ulnar claw (HP:0001178)1.88428800
103Hyperglycemia (HP:0003074)1.86769535
104Protuberant abdomen (HP:0001538)1.85207990
105Cerebral hemorrhage (HP:0001342)1.84683500
106Segmental peripheral demyelination/remyelination (HP:0003481)1.84392166
107Abnormality of chloride homeostasis (HP:0011422)1.84314500
108Enlarged kidneys (HP:0000105)1.82795940
109Gingival bleeding (HP:0000225)1.82561190
110Muscle fiber splitting (HP:0003555)1.81764671
111Onion bulb formation (HP:0003383)1.81142805
112Hyperventilation (HP:0002883)1.80223700
113Late onset (HP:0003584)1.79807573
114Sudden death (HP:0001699)1.79240768
115Arthropathy (HP:0003040)1.78798368
116Increased CSF protein (HP:0002922)1.78459797
117Alkalosis (HP:0001948)1.78297827
118Nephritis (HP:0000123)1.77807891
119Widely spaced teeth (HP:0000687)1.77727300
120Exocrine pancreatic insufficiency (HP:0001738)1.77398263
121Difficulty running (HP:0009046)1.76507543
122Dicarboxylic aciduria (HP:0003215)1.75788984
123Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75788984
124Abnormality of the gallbladder (HP:0005264)1.75667140
125Fair hair (HP:0002286)1.75349218
126Urinary glycosaminoglycan excretion (HP:0003541)1.74489874
127Mucopolysacchariduria (HP:0008155)1.74489874
128Action tremor (HP:0002345)1.72676495
129Atonic seizures (HP:0010819)1.72537381
130Flat acetabular roof (HP:0003180)1.72218298
131Pulmonary embolism (HP:0002204)1.71840801
132Thrombophlebitis (HP:0004418)1.71727927
133Vomiting (HP:0002013)1.71531890
134Abnormal tarsal ossification (HP:0008369)1.71001156
135Epileptic encephalopathy (HP:0200134)1.70551716
136Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.70036623
137Cerebral edema (HP:0002181)1.69801154
138Menorrhagia (HP:0000132)1.69749671
139Generalized hypopigmentation of hair (HP:0011358)1.69186957
140Turricephaly (HP:0000262)1.68976915
141Abnormality of mucopolysaccharide metabolism (HP:0011020)1.68234549
142Abnormality of polysaccharide metabolism (HP:0011012)1.68234549
143Abnormality of glycosaminoglycan metabolism (HP:0004371)1.68234549
144Abnormality of vitamin metabolism (HP:0100508)1.67767764
145Abnormal enzyme/coenzyme activity (HP:0012379)1.67462887
146Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.67460320
147Abnormality of the left ventricular outflow tract (HP:0011103)1.65133605
148Subaortic stenosis (HP:0001682)1.65133605
149Narrow palate (HP:0000189)1.64793793
150Dysmetric saccades (HP:0000641)1.64379620
151Dysostosis multiplex (HP:0000943)1.63657020
152Obstructive sleep apnea (HP:0002870)1.63128545
153Germ cell neoplasia (HP:0100728)1.62733783
154Ventricular arrhythmia (HP:0004308)1.60652180
155Abnormality of potassium homeostasis (HP:0011042)1.60590303
156Thin bony cortex (HP:0002753)1.60589554
157Stomach cancer (HP:0012126)1.60131299
158Absent speech (HP:0001344)1.59941002
159Arterial tortuosity (HP:0005116)1.59000910
160Optic neuritis (HP:0100653)1.58113420
161Retrobulbar optic neuritis (HP:0100654)1.58113420
162Heart block (HP:0012722)1.57331836
163Orchitis (HP:0100796)1.57314403
164Widely patent fontanelles and sutures (HP:0004492)1.56946282
165Potter facies (HP:0002009)1.56140032
166Facial shape deformation (HP:0011334)1.56140032
167Neoplasm of the tracheobronchial system (HP:0100552)1.55408496
168Degeneration of the lateral corticospinal tracts (HP:0002314)1.55309435

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK2.89791557
2BCKDK2.79044599
3SIK12.77415074
4INSRR2.70104166
5FGFR42.41006923
6ERN12.25140949
7TAOK32.21370090
8MAP2K42.11635621
9EPHA42.05760855
10DAPK22.02110128
11PRPF4B1.74630700
12ERBB41.74268753
13MST1R1.72940992
14PIK3CG1.67052512
15MAP3K21.56423491
16TRPM71.53162775
17EPHB11.45071128
18FGFR21.41710601
19CAMK1G1.36300281
20PTK61.36117076
21CAMK1D1.34687725
22NTRK31.31415818
23STK391.30495474
24IRAK11.28534512
25STK381.28410282
26LATS11.24675244
27NTRK11.22796245
28STK38L1.19637276
29RIPK41.18154262
30RIPK11.16329273
31KSR21.15154034
32PIK3CA1.13854490
33ACVR1B1.13114897
34JAK11.09945319
35OBSCN1.09219325
36MYLK1.08842336
37PAK31.06351084
38MAPK151.04015966
39OXSR11.03573682
40MAP3K41.03530344
41IKBKE1.01051848
42CAMKK11.00636370
43HIPK20.99725889
44JAK20.99197674
45MARK20.99147203
46MAP3K70.98539271
47MAP3K130.98216143
48NLK0.97045246
49PDPK10.96475608
50SGK30.94635450
51BRD40.93953341
52AKT30.92762497
53BMPR20.92176994
54WNK40.92104915
55RET0.91988918
56PINK10.90845473
57SGK2230.88535994
58SGK4940.88535994
59TRIB30.87724715
60ABL20.87605118
61CHUK0.87168903
62PRKAA20.87037216
63MAP3K90.85398614
64PRKCQ0.84718784
65MAP3K140.84206909
66CAMK2G0.83923105
67EPHA30.81073142
68PRKCZ0.80299374
69TBK10.80053032
70IRAK20.79776434
71FER0.78733459
72PDGFRB0.78129874
73SGK20.78127603
74PTK20.77051603
75PKN10.76840651
76MAPK120.76123682
77MAP3K10.75443410
78PKN20.75421330
79CDC42BPA0.74833197
80MAP3K60.74826215
81PDK10.74150336
82PRKCH0.72509020
83MAP3K30.72212716
84NEK60.72136084
85SIK20.70761807
86GSK3A0.70410511
87TGFBR20.70244464
88CDK120.70223861
89ZAP700.69578323
90MET0.68541759
91SIK30.68270410
92MAPK110.68029440
93MAPKAPK30.66290453
94ERBB20.66005128
95CAMKK20.65652354
96NEK90.65531423
97CSNK1G20.64670354
98MARK30.63381115
99MAP2K10.62589195
100PRKACG0.62456004
101CAMK40.62375885
102FGFR30.61902801
103MARK10.61770437
104TNK20.61071472
105MAPK130.60452921
106PHKG20.60133498
107PHKG10.60133498
108MAP2K70.59709184
109PRKAA10.59186375
110IRAK40.58907021
111MINK10.58866759
112PAK60.58123083
113ITK0.57901097
114CAMK2A0.57820327
115LMTK20.57539558
116NUAK10.57402327
117CSK0.56517883
118CASK0.55921894
119DMPK0.55817266
120GRK50.55589127
121MATK0.55333186
122RPS6KB10.55316672
123DYRK1B0.55285609
124STK240.54400990
125CAMK2B0.53884734
126PRKCG0.53580651
127PRKG20.53462215
128MAPK70.53074509
129IKBKB0.53022444
130CDK50.51537230
131BLK0.49870862
132WNK10.49687743
133PRKCE0.49671084
134CAMK2D0.48482660
135TYK20.47129452
136GRK60.46866468
137IGF1R0.46164208
138SGK10.45940267
139PTK2B0.45112745
140MAP2K60.44529782
141PRKD10.43538943

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.19476895
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.14725065
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.01363540
4Arginine biosynthesis_Homo sapiens_hsa002202.94075264
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.90729595
6Complement and coagulation cascades_Homo sapiens_hsa046102.50290207
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.46694704
8Tryptophan metabolism_Homo sapiens_hsa003802.38574799
9Butanoate metabolism_Homo sapiens_hsa006502.22178837
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18608756
11Fatty acid degradation_Homo sapiens_hsa000712.17051392
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.10252399
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.96562045
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.96383556
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.90766025
16Sulfur metabolism_Homo sapiens_hsa009201.85236330
17Histidine metabolism_Homo sapiens_hsa003401.85210862
18Bile secretion_Homo sapiens_hsa049761.80811369
19Peroxisome_Homo sapiens_hsa041461.78978637
20PPAR signaling pathway_Homo sapiens_hsa033201.76897804
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74077071
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69393636
23Propanoate metabolism_Homo sapiens_hsa006401.68509379
24Staphylococcus aureus infection_Homo sapiens_hsa051501.66074820
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.63962814
26Chemical carcinogenesis_Homo sapiens_hsa052041.63597269
27Fatty acid metabolism_Homo sapiens_hsa012121.62690043
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59189361
29Caffeine metabolism_Homo sapiens_hsa002321.54705630
30Circadian rhythm_Homo sapiens_hsa047101.50488419
31beta-Alanine metabolism_Homo sapiens_hsa004101.50224003
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40731275
33Retinol metabolism_Homo sapiens_hsa008301.40647740
34Phenylalanine metabolism_Homo sapiens_hsa003601.31608230
35Starch and sucrose metabolism_Homo sapiens_hsa005001.26767635
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.26250118
37ABC transporters_Homo sapiens_hsa020101.22741399
38Steroid biosynthesis_Homo sapiens_hsa001001.20942517
39Fatty acid elongation_Homo sapiens_hsa000621.19829813
40Tyrosine metabolism_Homo sapiens_hsa003501.18750996
41Fat digestion and absorption_Homo sapiens_hsa049751.18647255
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17809173
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.17428043
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14683375
45Selenocompound metabolism_Homo sapiens_hsa004501.14530503
46Pyruvate metabolism_Homo sapiens_hsa006201.10426716
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03728720
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00789588
49Long-term potentiation_Homo sapiens_hsa047200.90187912
50Vitamin digestion and absorption_Homo sapiens_hsa049770.86960361
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86103381
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.80532645
53B cell receptor signaling pathway_Homo sapiens_hsa046620.80027863
54Amphetamine addiction_Homo sapiens_hsa050310.79422264
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77837455
56Arginine and proline metabolism_Homo sapiens_hsa003300.77143574
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76482054
58Glycerolipid metabolism_Homo sapiens_hsa005610.76214012
59FoxO signaling pathway_Homo sapiens_hsa040680.75290337
60Inositol phosphate metabolism_Homo sapiens_hsa005620.75235027
61Choline metabolism in cancer_Homo sapiens_hsa052310.74453215
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.73465805
63GnRH signaling pathway_Homo sapiens_hsa049120.70560916
64Osteoclast differentiation_Homo sapiens_hsa043800.70487797
65Estrogen signaling pathway_Homo sapiens_hsa049150.70413176
66Platelet activation_Homo sapiens_hsa046110.70296668
67Carbon metabolism_Homo sapiens_hsa012000.69384044
68TNF signaling pathway_Homo sapiens_hsa046680.68675433
69Other glycan degradation_Homo sapiens_hsa005110.68257785
70Prolactin signaling pathway_Homo sapiens_hsa049170.67929476
71Circadian entrainment_Homo sapiens_hsa047130.67297218
72Folate biosynthesis_Homo sapiens_hsa007900.65988522
73Oxytocin signaling pathway_Homo sapiens_hsa049210.65230273
74Long-term depression_Homo sapiens_hsa047300.64868633
75mTOR signaling pathway_Homo sapiens_hsa041500.63332851
76Sphingolipid metabolism_Homo sapiens_hsa006000.62624726
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.62580822
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62256429
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60894498
80cAMP signaling pathway_Homo sapiens_hsa040240.60478479
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60159214
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59265110
83Biosynthesis of amino acids_Homo sapiens_hsa012300.58992083
84Cholinergic synapse_Homo sapiens_hsa047250.57871783
85T cell receptor signaling pathway_Homo sapiens_hsa046600.57579947
86Fatty acid biosynthesis_Homo sapiens_hsa000610.56144507
87Hepatitis C_Homo sapiens_hsa051600.55936214
88ErbB signaling pathway_Homo sapiens_hsa040120.55399324
89Prion diseases_Homo sapiens_hsa050200.54311581
90Renal cell carcinoma_Homo sapiens_hsa052110.53593069
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53539769
92Lysine degradation_Homo sapiens_hsa003100.52632503
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51240380
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51027944
95Pertussis_Homo sapiens_hsa051330.50307859
96Insulin signaling pathway_Homo sapiens_hsa049100.49832421
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.49583325
98Dopaminergic synapse_Homo sapiens_hsa047280.49219459
99Endometrial cancer_Homo sapiens_hsa052130.49053875
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.48004991
101VEGF signaling pathway_Homo sapiens_hsa043700.47144294
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.47128774
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46982964
104Insulin resistance_Homo sapiens_hsa049310.39876183
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.39177699
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39141923
107Vitamin B6 metabolism_Homo sapiens_hsa007500.38649905
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36365624
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.35630873
110Glutathione metabolism_Homo sapiens_hsa004800.33832860
111Sulfur relay system_Homo sapiens_hsa041220.33720516
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30933298
113GABAergic synapse_Homo sapiens_hsa047270.28943464
114Thyroid hormone synthesis_Homo sapiens_hsa049180.27229800
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25469663
116Metabolic pathways_Homo sapiens_hsa011000.25301844
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24486102
118Glucagon signaling pathway_Homo sapiens_hsa049220.24349786
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.24208817
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.23599446
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.23472098
122Type II diabetes mellitus_Homo sapiens_hsa049300.21719681
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21335033
124Insulin secretion_Homo sapiens_hsa049110.20787875
125Mineral absorption_Homo sapiens_hsa049780.17634509
126Ovarian steroidogenesis_Homo sapiens_hsa049130.15463123
127Aldosterone synthesis and secretion_Homo sapiens_hsa049250.14377726
128Salivary secretion_Homo sapiens_hsa049700.13510558
129Linoleic acid metabolism_Homo sapiens_hsa005910.12594578
130Renin secretion_Homo sapiens_hsa049240.12245212
131African trypanosomiasis_Homo sapiens_hsa051430.11600585
132Galactose metabolism_Homo sapiens_hsa000520.09740502
133AMPK signaling pathway_Homo sapiens_hsa041520.07675455
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.07056975
135Cocaine addiction_Homo sapiens_hsa050300.06771186
136Pancreatic secretion_Homo sapiens_hsa049720.06716235
137Gastric acid secretion_Homo sapiens_hsa049710.06566357
138Glutamatergic synapse_Homo sapiens_hsa047240.06214337
139Amoebiasis_Homo sapiens_hsa051460.04193436
140Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.04136099
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.03661026
142Lysosome_Homo sapiens_hsa041420.03477462
143Dorso-ventral axis formation_Homo sapiens_hsa043200.03152744
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.02833412

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