Rank | Gene Set | Z-score |
---|---|---|
1 | cell wall macromolecule catabolic process (GO:0016998) | 8.95731751 |
2 | cell wall macromolecule metabolic process (GO:0044036) | 7.61319066 |
3 | positive regulation of cellular amide metabolic process (GO:0034250) | 4.45266351 |
4 | negative regulation of JAK-STAT cascade (GO:0046426) | 4.14237560 |
5 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 4.05936691 |
6 | fusion of sperm to egg plasma membrane (GO:0007342) | 3.87210507 |
7 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.82939163 |
8 | ATP synthesis coupled proton transport (GO:0015986) | 3.82939163 |
9 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.57433118 |
10 | response to UV-C (GO:0010225) | 3.57046846 |
11 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.52462900 |
12 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO | 3.44918575 |
13 | negative regulation of B cell apoptotic process (GO:0002903) | 3.40447672 |
14 | chaperone mediated protein folding requiring cofactor (GO:0051085) | 3.38163539 |
15 | viral mRNA export from host cell nucleus (GO:0046784) | 3.35762253 |
16 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.35490042 |
17 | peptidyl-histidine modification (GO:0018202) | 3.31703747 |
18 | sulfation (GO:0051923) | 3.21747183 |
19 | base-excision repair, AP site formation (GO:0006285) | 3.16653142 |
20 | DNA deamination (GO:0045006) | 3.16543183 |
21 | regulation of DNA damage checkpoint (GO:2000001) | 3.13525123 |
22 | pseudouridine synthesis (GO:0001522) | 3.10639711 |
23 | ATP hydrolysis coupled proton transport (GO:0015991) | 3.09553486 |
24 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 3.09553486 |
25 | mismatch repair (GO:0006298) | 3.08610916 |
26 | preassembly of GPI anchor in ER membrane (GO:0016254) | 3.07272029 |
27 | pentose-phosphate shunt (GO:0006098) | 3.06573097 |
28 | plasma membrane fusion (GO:0045026) | 3.06083428 |
29 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.03989571 |
30 | purine deoxyribonucleoside triphosphate metabolic process (GO:0009215) | 3.01204815 |
31 | cellular copper ion homeostasis (GO:0006878) | 2.99841837 |
32 | regulation of meiosis I (GO:0060631) | 2.98652044 |
33 | copper ion homeostasis (GO:0055070) | 2.94977249 |
34 | regulation of B cell apoptotic process (GO:0002902) | 2.92156389 |
35 | prenylation (GO:0097354) | 2.90604271 |
36 | protein prenylation (GO:0018342) | 2.90604271 |
37 | short-chain fatty acid metabolic process (GO:0046459) | 2.89592661 |
38 | regulation of somitogenesis (GO:0014807) | 2.88590299 |
39 | righting reflex (GO:0060013) | 2.88435512 |
40 | deoxyribose phosphate catabolic process (GO:0046386) | 2.88173486 |
41 | deoxyribonucleotide catabolic process (GO:0009264) | 2.87715577 |
42 | nucleotide salvage (GO:0043173) | 2.87338758 |
43 | purine deoxyribonucleotide metabolic process (GO:0009151) | 2.78169161 |
44 | G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589) | 2.76647028 |
45 | purine deoxyribonucleotide catabolic process (GO:0009155) | 2.72396469 |
46 | negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642) | 2.70960339 |
47 | autophagic vacuole fusion (GO:0000046) | 2.70391010 |
48 | purine-containing compound salvage (GO:0043101) | 2.70297406 |
49 | multicellular organism reproduction (GO:0032504) | 2.70102272 |
50 | maturation of 5.8S rRNA (GO:0000460) | 2.70036582 |
51 | NADPH regeneration (GO:0006740) | 2.66955605 |
52 | heme biosynthetic process (GO:0006783) | 2.65867114 |
53 | GTP biosynthetic process (GO:0006183) | 2.64962940 |
54 | copper ion transport (GO:0006825) | 2.64721540 |
55 | positive regulation of protein kinase C signaling (GO:0090037) | 2.64476311 |
56 | regulation of beta-amyloid formation (GO:1902003) | 2.63726597 |
57 | 2-deoxyribonucleotide metabolic process (GO:0009394) | 2.62455511 |
58 | heme metabolic process (GO:0042168) | 2.62421649 |
59 | metallo-sulfur cluster assembly (GO:0031163) | 2.60974755 |
60 | iron-sulfur cluster assembly (GO:0016226) | 2.60974755 |
61 | regulation of mast cell activation (GO:0033003) | 2.59763862 |
62 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.59440637 |
63 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.59440637 |
64 | response to peptidoglycan (GO:0032494) | 2.59070941 |
65 | snRNA processing (GO:0016180) | 2.57050204 |
66 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.56940197 |
67 | piRNA metabolic process (GO:0034587) | 2.56752611 |
68 | meiosis I (GO:0007127) | 2.54865585 |
69 | dosage compensation (GO:0007549) | 2.54307274 |
70 | hemoglobin metabolic process (GO:0020027) | 2.53716367 |
71 | protein K6-linked ubiquitination (GO:0085020) | 2.52532846 |
72 | deoxyribose phosphate metabolic process (GO:0019692) | 2.52104343 |
73 | protoporphyrinogen IX metabolic process (GO:0046501) | 2.51489138 |
74 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.49325298 |
75 | male meiosis I (GO:0007141) | 2.49109027 |
76 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.48250304 |
77 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.48250304 |
78 | pyrimidine nucleoside salvage (GO:0043097) | 2.47509600 |
79 | pyrimidine-containing compound salvage (GO:0008655) | 2.47509600 |
80 | centriole replication (GO:0007099) | 2.45770026 |
81 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.45657104 |
82 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.45657104 |
83 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.45657104 |
84 | growth hormone receptor signaling pathway (GO:0060396) | 2.44196608 |
85 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 2.43115634 |
86 | GMP metabolic process (GO:0046037) | 2.39976018 |
87 | negative regulation of interleukin-1 beta production (GO:0032691) | 2.38765312 |
88 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 2.38420257 |
89 | positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725) | 2.36848775 |
90 | tRNA processing (GO:0008033) | 2.36437426 |
91 | deoxyribonucleotide metabolic process (GO:0009262) | 2.36164321 |
92 | regulation of protein heterodimerization activity (GO:0043497) | 2.35774002 |
93 | positive regulation of B cell differentiation (GO:0045579) | 2.35609439 |
94 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 2.35272635 |
95 | CTP metabolic process (GO:0046036) | 2.35045229 |
96 | CTP biosynthetic process (GO:0006241) | 2.35045229 |
97 | nucleoside salvage (GO:0043174) | 2.34662186 |
98 | poly(A)+ mRNA export from nucleus (GO:0016973) | 2.34605384 |
99 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.34491657 |
100 | termination of RNA polymerase III transcription (GO:0006386) | 2.34491657 |
Rank | Gene Set | Z-score |
---|---|---|
1 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 3.94517771 |
2 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.80722233 |
3 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.73894535 |
4 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.32357498 |
5 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.05901531 |
6 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.97828114 |
7 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.95092978 |
8 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.89094086 |
9 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.88115475 |
10 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.85957349 |
11 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.83106620 |
12 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.80655901 |
13 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.76948855 |
14 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.67178422 |
15 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.58413923 |
16 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.55207982 |
17 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 2.36291011 |
18 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.35498256 |
19 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.15732009 |
20 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.02683408 |
21 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.97919041 |
22 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.95940789 |
23 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.95065652 |
24 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.93264026 |
25 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.91276732 |
26 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.91250107 |
27 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.89867381 |
28 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.86078427 |
29 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.83426854 |
30 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.81540177 |
31 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.77912740 |
32 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.72760991 |
33 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.71054493 |
34 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.70693798 |
35 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.69908523 |
36 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.69880047 |
37 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.68847213 |
38 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.67511391 |
39 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.66907584 |
40 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.65725620 |
41 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.65392703 |
42 | GATA3_26560356_Chip-Seq_TH2_Human | 1.61415383 |
43 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.60978837 |
44 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.58833722 |
45 | MYB_26560356_Chip-Seq_TH2_Human | 1.58529885 |
46 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.52373055 |
47 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.49270251 |
48 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.46948854 |
49 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.45549946 |
50 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.44328735 |
51 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.41139244 |
52 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.40804008 |
53 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.40648264 |
54 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.40587590 |
55 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.40479591 |
56 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.39703966 |
57 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.39163199 |
58 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.38810690 |
59 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.34298944 |
60 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.30963278 |
61 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.28203590 |
62 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.25649286 |
63 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.25534007 |
64 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.25215533 |
65 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.24937753 |
66 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.23921844 |
67 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.22060798 |
68 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.21250392 |
69 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.18560893 |
70 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.17599933 |
71 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.17425137 |
72 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.16656399 |
73 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.15504878 |
74 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.15363277 |
75 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.14235693 |
76 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.11781708 |
77 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.11713236 |
78 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.11566165 |
79 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.10258908 |
80 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.10216894 |
81 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.09580045 |
82 | LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.08820899 |
83 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.07521645 |
84 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.07417741 |
85 | UTX_26944678_Chip-Seq_JUKART_Human | 1.06539585 |
86 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.06304505 |
87 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.06238402 |
88 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.04757635 |
89 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.04041578 |
90 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.03796198 |
91 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.03555036 |
92 | P300_27268052_Chip-Seq_Bcells_Human | 1.03157999 |
93 | MYB_26560356_Chip-Seq_TH1_Human | 1.02841284 |
94 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.01861778 |
95 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.00238501 |
96 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.98533392 |
97 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.95758791 |
98 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.93922846 |
99 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.91470286 |
100 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.89419579 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003011_delayed_dark_adaptation | 4.96501389 |
2 | MP0000013_abnormal_adipose_tissue | 3.20266226 |
3 | MP0003656_abnormal_erythrocyte_physiolo | 3.15971346 |
4 | MP0002138_abnormal_hepatobiliary_system | 2.92014647 |
5 | MP0003806_abnormal_nucleotide_metabolis | 2.77664503 |
6 | MP0001968_abnormal_touch/_nociception | 2.74888409 |
7 | MP0005451_abnormal_body_composition | 2.59077409 |
8 | MP0001835_abnormal_antigen_presentation | 2.58038147 |
9 | MP0003172_abnormal_lysosome_physiology | 2.56912647 |
10 | MP0009333_abnormal_splenocyte_physiolog | 2.52963756 |
11 | MP0005464_abnormal_platelet_physiology | 2.15784937 |
12 | MP0002822_catalepsy | 2.13364218 |
13 | MP0009785_altered_susceptibility_to | 2.11185063 |
14 | MP0010368_abnormal_lymphatic_system | 2.09367274 |
15 | MP0003786_premature_aging | 1.88407727 |
16 | MP0005000_abnormal_immune_tolerance | 1.86151242 |
17 | MP0000465_gastrointestinal_hemorrhage | 1.84182935 |
18 | MP0002396_abnormal_hematopoietic_system | 1.82014470 |
19 | MP0008058_abnormal_DNA_repair | 1.75340304 |
20 | MP0005645_abnormal_hypothalamus_physiol | 1.71701528 |
21 | MP0002148_abnormal_hypersensitivity_rea | 1.71610378 |
22 | MP0008007_abnormal_cellular_replicative | 1.70324328 |
23 | MP0001800_abnormal_humoral_immune | 1.69117195 |
24 | MP0005410_abnormal_fertilization | 1.64126044 |
25 | MP0003436_decreased_susceptibility_to | 1.57983498 |
26 | MP0002733_abnormal_thermal_nociception | 1.51968902 |
27 | MP0003186_abnormal_redox_activity | 1.48529589 |
28 | MP0003693_abnormal_embryo_hatching | 1.46904953 |
29 | MP0002452_abnormal_antigen_presenting | 1.46766245 |
30 | MP0005397_hematopoietic_system_phenotyp | 1.46534252 |
31 | MP0001545_abnormal_hematopoietic_system | 1.46534252 |
32 | MP0008995_early_reproductive_senescence | 1.43929211 |
33 | MP0002398_abnormal_bone_marrow | 1.43811979 |
34 | MP0004147_increased_porphyrin_level | 1.43419033 |
35 | MP0002736_abnormal_nociception_after | 1.41529088 |
36 | MP0002723_abnormal_immune_serum | 1.40727634 |
37 | MP0005075_abnormal_melanosome_morpholog | 1.35472589 |
38 | MP0006036_abnormal_mitochondrial_physio | 1.34898065 |
39 | MP0002420_abnormal_adaptive_immunity | 1.34808911 |
40 | MP0001819_abnormal_immune_cell | 1.32267582 |
41 | MP0002419_abnormal_innate_immunity | 1.31606542 |
42 | MP0000681_abnormal_thyroid_gland | 1.30608090 |
43 | MP0009764_decreased_sensitivity_to | 1.25475018 |
44 | MP0005025_abnormal_response_to | 1.25417426 |
45 | MP0010094_abnormal_chromosome_stability | 1.22560198 |
46 | MP0005360_urolithiasis | 1.18313741 |
47 | MP0008469_abnormal_protein_level | 1.17967381 |
48 | MP0000716_abnormal_immune_system | 1.16010019 |
49 | MP0000689_abnormal_spleen_morphology | 1.13920051 |
50 | MP0006276_abnormal_autonomic_nervous | 1.12584915 |
51 | MP0002429_abnormal_blood_cell | 1.12254311 |
52 | MP0000003_abnormal_adipose_tissue | 1.11369523 |
53 | MP0005220_abnormal_exocrine_pancreas | 1.11138556 |
54 | MP0001727_abnormal_embryo_implantation | 1.10317991 |
55 | MP0005319_abnormal_enzyme/_coenzyme | 1.09167068 |
56 | MP0001853_heart_inflammation | 1.07662577 |
57 | MP0001243_abnormal_dermal_layer | 1.07501609 |
58 | MP0001845_abnormal_inflammatory_respons | 1.07023277 |
59 | MP0003724_increased_susceptibility_to | 1.05279500 |
60 | MP0008260_abnormal_autophagy | 1.04443569 |
61 | MP0009697_abnormal_copulation | 1.02705608 |
62 | MP0008004_abnormal_stomach_pH | 1.02513222 |
63 | MP0010386_abnormal_urinary_bladder | 1.01439437 |
64 | MP0003191_abnormal_cellular_cholesterol | 1.00965788 |
65 | MP0002722_abnormal_immune_system | 1.00965441 |
66 | MP0005671_abnormal_response_to | 1.00227826 |
67 | MP0009763_increased_sensitivity_to | 0.99921104 |
68 | MP0009780_abnormal_chondrocyte_physiolo | 0.98206871 |
69 | MP0009278_abnormal_bone_marrow | 0.97201460 |
70 | MP0000372_irregular_coat_pigmentation | 0.92089659 |
71 | MP0003828_pulmonary_edema | 0.91598922 |
72 | MP0001970_abnormal_pain_threshold | 0.91232639 |
73 | MP0004947_skin_inflammation | 0.91162110 |
74 | MP0008775_abnormal_heart_ventricle | 0.89806833 |
75 | MP0005551_abnormal_eye_electrophysiolog | 0.89317315 |
76 | MP0004782_abnormal_surfactant_physiolog | 0.89150041 |
77 | MP0005334_abnormal_fat_pad | 0.87222986 |
78 | MP0003880_abnormal_central_pattern | 0.86020431 |
79 | MP0002019_abnormal_tumor_incidence | 0.85851723 |
80 | MP0008872_abnormal_physiological_respon | 0.85380718 |
81 | MP0004957_abnormal_blastocyst_morpholog | 0.84679686 |
82 | MP0005646_abnormal_pituitary_gland | 0.83649157 |
83 | MP0005058_abnormal_lysosome_morphology | 0.83317957 |
84 | MP0003111_abnormal_nucleus_morphology | 0.82212491 |
85 | MP0008875_abnormal_xenobiotic_pharmacok | 0.81150246 |
86 | MP0005535_abnormal_body_temperature | 0.77642215 |
87 | MP0002132_abnormal_respiratory_system | 0.77491581 |
88 | MP0003950_abnormal_plasma_membrane | 0.76277387 |
89 | MP0000490_abnormal_crypts_of | 0.75977698 |
90 | MP0000358_abnormal_cell_content/ | 0.75648349 |
91 | MP0004145_abnormal_muscle_electrophysio | 0.75035197 |
92 | MP0002102_abnormal_ear_morphology | 0.73677604 |
93 | MP0002970_abnormal_white_adipose | 0.73491466 |
94 | MP0009765_abnormal_xenobiotic_induced | 0.73245779 |
95 | MP0005636_abnormal_mineral_homeostasis | 0.71625751 |
96 | MP0006035_abnormal_mitochondrial_morpho | 0.70983747 |
97 | MP0003718_maternal_effect | 0.70578306 |
98 | MP0003183_abnormal_peptide_metabolism | 0.70296240 |
99 | MP0010771_integument_phenotype | 0.69932310 |
100 | MP0008873_increased_physiological_sensi | 0.68492064 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Optic neuritis (HP:0100653) | 5.05087906 |
2 | Retrobulbar optic neuritis (HP:0100654) | 5.05087906 |
3 | Orchitis (HP:0100796) | 4.56534840 |
4 | Myositis (HP:0100614) | 4.10966482 |
5 | Retinal dysplasia (HP:0007973) | 4.08196267 |
6 | Decreased central vision (HP:0007663) | 3.72386556 |
7 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.70213828 |
8 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 3.65065329 |
9 | Cone-rod dystrophy (HP:0000548) | 3.61125180 |
10 | Keratoconjunctivitis sicca (HP:0001097) | 3.54565947 |
11 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 3.53261980 |
12 | Tongue fasciculations (HP:0001308) | 3.52507285 |
13 | Nonimmune hydrops fetalis (HP:0001790) | 3.49045583 |
14 | Acute hepatic failure (HP:0006554) | 3.34816675 |
15 | Ulnar claw (HP:0001178) | 3.30818547 |
16 | Keratoconjunctivitis (HP:0001096) | 3.25162563 |
17 | Muscle fibrillation (HP:0010546) | 3.18006971 |
18 | Microvesicular hepatic steatosis (HP:0001414) | 3.10929950 |
19 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 3.00325289 |
20 | Hepatocellular necrosis (HP:0001404) | 2.88629324 |
21 | Tetraparesis (HP:0002273) | 2.85535563 |
22 | Aplastic anemia (HP:0001915) | 2.84792552 |
23 | Anomalous pulmonary venous return (HP:0010772) | 2.78198883 |
24 | Abolished electroretinogram (ERG) (HP:0000550) | 2.73606689 |
25 | Hepatic necrosis (HP:0002605) | 2.72075713 |
26 | Prolonged bleeding time (HP:0003010) | 2.67807786 |
27 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.62014555 |
28 | Abnormality of alanine metabolism (HP:0010916) | 2.62014555 |
29 | Hyperalaninemia (HP:0003348) | 2.62014555 |
30 | Petechiae (HP:0000967) | 2.60998091 |
31 | Encephalitis (HP:0002383) | 2.59964825 |
32 | Increased serum ferritin (HP:0003281) | 2.59604387 |
33 | Amelogenesis imperfecta (HP:0000705) | 2.54621913 |
34 | Segmental peripheral demyelination/remyelination (HP:0003481) | 2.49788581 |
35 | Oral leukoplakia (HP:0002745) | 2.48721799 |
36 | Panhypogammaglobulinemia (HP:0003139) | 2.45799135 |
37 | Amyloidosis (HP:0011034) | 2.45008624 |
38 | Generalized aminoaciduria (HP:0002909) | 2.44648790 |
39 | Arterial thrombosis (HP:0004420) | 2.40277924 |
40 | Abnormality of the pulmonary veins (HP:0011718) | 2.38861478 |
41 | Prostate neoplasm (HP:0100787) | 2.37781793 |
42 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.37684571 |
43 | Abnormality of transition element cation homeostasis (HP:0011030) | 2.35117927 |
44 | Gangrene (HP:0100758) | 2.34667041 |
45 | Abnormality of dental color (HP:0011073) | 2.33618738 |
46 | Pulmonary infiltrates (HP:0002113) | 2.32290548 |
47 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.32114565 |
48 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.32114565 |
49 | Long foot (HP:0001833) | 2.31330542 |
50 | Pustule (HP:0200039) | 2.29171656 |
51 | Neoplasm of the adrenal cortex (HP:0100641) | 2.28031611 |
52 | Dyschromatopsia (HP:0007641) | 2.28003548 |
53 | Progressive muscle weakness (HP:0003323) | 2.27494776 |
54 | Abnormality of iron homeostasis (HP:0011031) | 2.26951391 |
55 | B lymphocytopenia (HP:0010976) | 2.25941514 |
56 | Increased muscle lipid content (HP:0009058) | 2.23965579 |
57 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.21275643 |
58 | Impaired proprioception (HP:0010831) | 2.20031669 |
59 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.18345660 |
60 | Capillary hemangiomas (HP:0005306) | 2.17083073 |
61 | Rough bone trabeculation (HP:0100670) | 2.14414168 |
62 | Lipid accumulation in hepatocytes (HP:0006561) | 2.13422538 |
63 | Anorexia (HP:0002039) | 2.12974974 |
64 | Abnormality of the vocal cords (HP:0008777) | 2.12309686 |
65 | Increased CSF lactate (HP:0002490) | 2.11672847 |
66 | Abnormality of B cell number (HP:0010975) | 2.11344672 |
67 | Visual hallucinations (HP:0002367) | 2.09572343 |
68 | Abnormality of the prostate (HP:0008775) | 2.09158251 |
69 | Congenital stationary night blindness (HP:0007642) | 2.08717700 |
70 | Constricted visual fields (HP:0001133) | 2.08446511 |
71 | Mitochondrial inheritance (HP:0001427) | 2.08147382 |
72 | Increased serum lactate (HP:0002151) | 2.07022834 |
73 | Acute encephalopathy (HP:0006846) | 2.04866681 |
74 | Meningitis (HP:0001287) | 2.04374539 |
75 | Gastrointestinal infarctions (HP:0005244) | 2.03213393 |
76 | Diaphragmatic weakness (HP:0009113) | 2.01369241 |
77 | Ependymoma (HP:0002888) | 2.01331926 |
78 | Glomerulopathy (HP:0100820) | 2.01068740 |
79 | Acute necrotizing encephalopathy (HP:0006965) | 2.00426463 |
80 | Areflexia of lower limbs (HP:0002522) | 1.99289355 |
81 | Increased intramyocellular lipid droplets (HP:0012240) | 1.98040017 |
82 | 3-Methylglutaconic aciduria (HP:0003535) | 1.97054886 |
83 | Episodic fever (HP:0001954) | 1.93509048 |
84 | Polyneuropathy (HP:0001271) | 1.92049464 |
85 | Vacuolated lymphocytes (HP:0001922) | 1.91837096 |
86 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.91100455 |
87 | Hemoptysis (HP:0002105) | 1.90130211 |
88 | Epistaxis (HP:0000421) | 1.88432915 |
89 | Degeneration of anterior horn cells (HP:0002398) | 1.86291922 |
90 | Abnormality of the anterior horn cell (HP:0006802) | 1.86291922 |
91 | Lactic acidosis (HP:0003128) | 1.84224995 |
92 | Pancreatitis (HP:0001733) | 1.83985360 |
93 | Increased IgE level (HP:0003212) | 1.83904423 |
94 | Late onset (HP:0003584) | 1.79723559 |
95 | Exercise intolerance (HP:0003546) | 1.78229460 |
96 | Microcytic anemia (HP:0001935) | 1.77075124 |
97 | Granulocytopenia (HP:0001913) | 1.75562536 |
98 | Recurrent viral infections (HP:0004429) | 1.75517212 |
99 | Hypertensive crisis (HP:0100735) | 1.75169757 |
100 | Gastrointestinal inflammation (HP:0004386) | 1.72168814 |
Rank | Gene Set | Z-score |
---|---|---|
1 | KDR | 7.65994544 |
2 | BMPR1B | 4.62401369 |
3 | BLK | 4.37823089 |
4 | SCYL2 | 4.35948967 |
5 | CDK8 | 3.90183644 |
6 | TESK2 | 3.25910687 |
7 | TGFBR1 | 2.34938901 |
8 | MAP2K6 | 2.01548598 |
9 | VRK2 | 1.87402883 |
10 | RPS6KA4 | 1.83180965 |
11 | TEC | 1.80814723 |
12 | BCKDK | 1.65423347 |
13 | KIT | 1.61892392 |
14 | STK4 | 1.61614894 |
15 | VRK1 | 1.59767778 |
16 | CDK9 | 1.59057583 |
17 | NUAK1 | 1.57998957 |
18 | NME2 | 1.51508664 |
19 | TAOK3 | 1.50388789 |
20 | BMPR2 | 1.44960607 |
21 | MAP4K1 | 1.40260289 |
22 | ILK | 1.36284414 |
23 | PIM2 | 1.35197003 |
24 | HIPK2 | 1.31508578 |
25 | TLK1 | 1.25953749 |
26 | MAP4K2 | 1.24745957 |
27 | FES | 1.20247102 |
28 | GRK6 | 1.19935209 |
29 | SYK | 1.18438963 |
30 | RAF1 | 1.13522452 |
31 | DAPK1 | 1.07931967 |
32 | MAPKAPK5 | 1.06590449 |
33 | IKBKB | 0.99588551 |
34 | MAP2K3 | 0.98529445 |
35 | BMX | 0.98196505 |
36 | CSF1R | 0.92488475 |
37 | EIF2AK3 | 0.89728264 |
38 | FLT3 | 0.88060375 |
39 | LYN | 0.83358700 |
40 | ZAK | 0.79392024 |
41 | RPS6KA5 | 0.79252077 |
42 | MAPKAPK3 | 0.78917585 |
43 | CCNB1 | 0.76103412 |
44 | TBK1 | 0.75155543 |
45 | ABL2 | 0.74371818 |
46 | IRAK3 | 0.74143053 |
47 | EIF2AK1 | 0.73048208 |
48 | ARAF | 0.72343428 |
49 | IRAK1 | 0.68759175 |
50 | DAPK3 | 0.67481908 |
51 | RIPK4 | 0.67481705 |
52 | CDC7 | 0.66543677 |
53 | PBK | 0.66283049 |
54 | RPS6KB2 | 0.66075396 |
55 | PIM1 | 0.64915242 |
56 | ATR | 0.63416289 |
57 | CDK7 | 0.62711804 |
58 | CDK3 | 0.60654537 |
59 | PKN1 | 0.59452571 |
60 | STK16 | 0.59219626 |
61 | TRPM7 | 0.57870274 |
62 | ZAP70 | 0.56810975 |
63 | TXK | 0.54280078 |
64 | IKBKE | 0.54273030 |
65 | CDK19 | 0.51648250 |
66 | ITK | 0.49024918 |
67 | CAMK2D | 0.47179519 |
68 | GRK1 | 0.40248345 |
69 | IRAK4 | 0.39873776 |
70 | WNK3 | 0.39159401 |
71 | PAK1 | 0.38998856 |
72 | MAPKAPK2 | 0.38173192 |
73 | BUB1 | 0.38088884 |
74 | LIMK1 | 0.36976667 |
75 | BTK | 0.36649348 |
76 | ERBB3 | 0.36271255 |
77 | GRK5 | 0.35309533 |
78 | PLK3 | 0.35173575 |
79 | LMTK2 | 0.34241765 |
80 | MAP3K14 | 0.32993470 |
81 | PIK3CG | 0.32949247 |
82 | MAP3K1 | 0.31543313 |
83 | CAMK2G | 0.30841359 |
84 | LCK | 0.29547237 |
85 | DYRK3 | 0.26901714 |
86 | AURKB | 0.26599951 |
87 | CDK4 | 0.26084348 |
88 | CSNK2A2 | 0.25037922 |
89 | PAK4 | 0.25032855 |
90 | ATM | 0.24858190 |
91 | PLK4 | 0.24828481 |
92 | MAPK11 | 0.24295757 |
93 | SMG1 | 0.24251251 |
94 | ERN1 | 0.23235492 |
95 | ABL1 | 0.22314115 |
96 | CSNK2A1 | 0.22222599 |
97 | PRKG1 | 0.20269541 |
98 | MAP3K12 | 0.18499797 |
99 | NEK6 | 0.18126519 |
100 | CSNK1A1 | 0.17313393 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Proteasome_Homo sapiens_hsa03050 | 4.03433831 |
2 | Asthma_Homo sapiens_hsa05310 | 2.98514960 |
3 | Base excision repair_Homo sapiens_hsa03410 | 2.41142802 |
4 | RNA polymerase_Homo sapiens_hsa03020 | 2.37167771 |
5 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.28983940 |
6 | Allograft rejection_Homo sapiens_hsa05330 | 2.16166093 |
7 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 2.08005910 |
8 | Parkinsons disease_Homo sapiens_hsa05012 | 2.04423419 |
9 | Regulation of autophagy_Homo sapiens_hsa04140 | 2.02679559 |
10 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.97757481 |
11 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.97675921 |
12 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.93641678 |
13 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.86519544 |
14 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.81803741 |
15 | Homologous recombination_Homo sapiens_hsa03440 | 1.76577172 |
16 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.71822944 |
17 | DNA replication_Homo sapiens_hsa03030 | 1.67716996 |
18 | Purine metabolism_Homo sapiens_hsa00230 | 1.66109285 |
19 | Mismatch repair_Homo sapiens_hsa03430 | 1.65519245 |
20 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.64247592 |
21 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.61920310 |
22 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.59896659 |
23 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.58263507 |
24 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.56039678 |
25 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.54418138 |
26 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.53478964 |
27 | Leishmaniasis_Homo sapiens_hsa05140 | 1.51961714 |
28 | Other glycan degradation_Homo sapiens_hsa00511 | 1.48382188 |
29 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.48037382 |
30 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.43325038 |
31 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.39990628 |
32 | RNA transport_Homo sapiens_hsa03013 | 1.39448008 |
33 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.31638130 |
34 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.31333571 |
35 | Basal transcription factors_Homo sapiens_hsa03022 | 1.23273310 |
36 | Huntingtons disease_Homo sapiens_hsa05016 | 1.22522304 |
37 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.22046278 |
38 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.16551663 |
39 | Ribosome_Homo sapiens_hsa03010 | 1.13266135 |
40 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.11416509 |
41 | Phototransduction_Homo sapiens_hsa04744 | 1.10289311 |
42 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.09937827 |
43 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.07464772 |
44 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.07138966 |
45 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.05532828 |
46 | Viral myocarditis_Homo sapiens_hsa05416 | 1.04697906 |
47 | Legionellosis_Homo sapiens_hsa05134 | 1.04074606 |
48 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.03988346 |
49 | Spliceosome_Homo sapiens_hsa03040 | 1.02795144 |
50 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.02650421 |
51 | Alzheimers disease_Homo sapiens_hsa05010 | 1.02200675 |
52 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.01564184 |
53 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.99389899 |
54 | Platelet activation_Homo sapiens_hsa04611 | 0.99284162 |
55 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.98693617 |
56 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.98259492 |
57 | RNA degradation_Homo sapiens_hsa03018 | 0.95628309 |
58 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.93063304 |
59 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.91741030 |
60 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.91613893 |
61 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.91450697 |
62 | Influenza A_Homo sapiens_hsa05164 | 0.90610128 |
63 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.86522810 |
64 | Peroxisome_Homo sapiens_hsa04146 | 0.86229787 |
65 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.84391348 |
66 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.84189047 |
67 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.80789531 |
68 | Protein export_Homo sapiens_hsa03060 | 0.79206537 |
69 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.79054102 |
70 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.77288802 |
71 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.74632811 |
72 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.74626210 |
73 | Tuberculosis_Homo sapiens_hsa05152 | 0.74546754 |
74 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.73922905 |
75 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.73232748 |
76 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.72356212 |
77 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.69547629 |
78 | Lysosome_Homo sapiens_hsa04142 | 0.66025087 |
79 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.63359997 |
80 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.63035208 |
81 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.62590058 |
82 | Metabolic pathways_Homo sapiens_hsa01100 | 0.53712751 |
83 | Salmonella infection_Homo sapiens_hsa05132 | 0.51856099 |
84 | Retinol metabolism_Homo sapiens_hsa00830 | 0.49132094 |
85 | Shigellosis_Homo sapiens_hsa05131 | 0.49131746 |
86 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.47945768 |
87 | Phagosome_Homo sapiens_hsa04145 | 0.44323164 |
88 | Measles_Homo sapiens_hsa05162 | 0.43462076 |
89 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.42769714 |
90 | Carbon metabolism_Homo sapiens_hsa01200 | 0.41902395 |
91 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.41858633 |
92 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.41682043 |
93 | Alcoholism_Homo sapiens_hsa05034 | 0.40976591 |
94 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.39649454 |
95 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.36128330 |
96 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.35152942 |
97 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.34815707 |
98 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.33955920 |
99 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.33448959 |
100 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.32863942 |