RNF11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.20398985
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.90589494
3synaptic vesicle maturation (GO:0016188)3.89325761
4glutamate secretion (GO:0014047)3.78448224
5locomotory exploration behavior (GO:0035641)3.77977414
6synaptic vesicle exocytosis (GO:0016079)3.75169134
7vocalization behavior (GO:0071625)3.74765846
8regulation of synaptic vesicle exocytosis (GO:2000300)3.62563641
9proline transport (GO:0015824)3.45735256
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.44169876
11layer formation in cerebral cortex (GO:0021819)3.43619197
12neuronal action potential propagation (GO:0019227)3.41147844
13positive regulation of receptor recycling (GO:0001921)3.34890540
14activation of protein kinase A activity (GO:0034199)3.34299186
15neurotransmitter secretion (GO:0007269)3.28502811
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.28008824
17regulation of glutamate receptor signaling pathway (GO:1900449)3.24991008
18regulation of synaptic vesicle transport (GO:1902803)3.23703499
19neuron cell-cell adhesion (GO:0007158)3.11520060
20exploration behavior (GO:0035640)3.05240980
21regulation of long-term neuronal synaptic plasticity (GO:0048169)2.99342437
22ionotropic glutamate receptor signaling pathway (GO:0035235)2.99341327
23positive regulation of neurotransmitter secretion (GO:0001956)2.98614343
24dendritic spine morphogenesis (GO:0060997)2.97262862
25gamma-aminobutyric acid transport (GO:0015812)2.96625315
26protein localization to synapse (GO:0035418)2.96084859
27cellular potassium ion homeostasis (GO:0030007)2.93914271
28regulation of synapse structural plasticity (GO:0051823)2.92649618
29neuron recognition (GO:0008038)2.91650713
30regulation of neuronal synaptic plasticity (GO:0048168)2.88861568
31synaptic vesicle docking involved in exocytosis (GO:0016081)2.86230149
32cellular response to epinephrine stimulus (GO:0071872)2.85465767
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.84179874
34cellular response to catecholamine stimulus (GO:0071870)2.83992895
35cellular response to monoamine stimulus (GO:0071868)2.83992895
36mating behavior (GO:0007617)2.81897638
37cytoskeletal anchoring at plasma membrane (GO:0007016)2.77541307
38neurotransmitter transport (GO:0006836)2.77358069
39regulation of platelet aggregation (GO:0090330)2.76411603
40glutamate receptor signaling pathway (GO:0007215)2.74109785
41positive regulation of insulin receptor signaling pathway (GO:0046628)2.74090589
42positive regulation of neurotransmitter transport (GO:0051590)2.66532886
43axonal fasciculation (GO:0007413)2.65830789
44regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.64027950
45positive regulation of fibroblast migration (GO:0010763)2.61507651
46clathrin coat assembly (GO:0048268)2.60532065
47negative regulation of dendrite morphogenesis (GO:0050774)2.59688063
48regulation of cAMP-dependent protein kinase activity (GO:2000479)2.56752384
49regulation of neurotransmitter levels (GO:0001505)2.56294725
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.55641503
51dendrite morphogenesis (GO:0048813)2.55338061
52gamma-aminobutyric acid signaling pathway (GO:0007214)2.54871816
53neuron-neuron synaptic transmission (GO:0007270)2.54315663
54positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.53437061
55regulation of dendritic spine morphogenesis (GO:0061001)2.52567341
56regulation of vesicle fusion (GO:0031338)2.52072165
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.51836194
58sodium ion export (GO:0071436)2.51626884
59regulation of clathrin-mediated endocytosis (GO:2000369)2.51242002
60regulation of voltage-gated calcium channel activity (GO:1901385)2.51195154
61positive regulation of vesicle fusion (GO:0031340)2.50306958
62regulation of receptor recycling (GO:0001919)2.50247961
63negative regulation of synaptic transmission, GABAergic (GO:0032229)2.49885688
64detection of calcium ion (GO:0005513)2.49533614
65regulation of excitatory postsynaptic membrane potential (GO:0060079)2.46360629
66vesicle transport along microtubule (GO:0047496)2.45449453
67synaptic transmission, glutamatergic (GO:0035249)2.45049697
68neurotransmitter-gated ion channel clustering (GO:0072578)2.44177188
69response to monoamine (GO:0071867)2.42623384
70response to catecholamine (GO:0071869)2.42623384
71negative regulation of inclusion body assembly (GO:0090084)2.42606994
72long-term memory (GO:0007616)2.42164582
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.40818432
74negative regulation of neurotransmitter transport (GO:0051589)2.39781802
75protein localization to endosome (GO:0036010)2.37828653
76negative regulation of homotypic cell-cell adhesion (GO:0034111)2.36848380
77nerve growth factor signaling pathway (GO:0038180)2.36805828
78negative regulation of microtubule polymerization (GO:0031115)2.36771838
79social behavior (GO:0035176)2.36629224
80intraspecies interaction between organisms (GO:0051703)2.36629224
81neuronal ion channel clustering (GO:0045161)2.35852136
82transmission of nerve impulse (GO:0019226)2.35435489
83regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.35256540
84L-amino acid import (GO:0043092)2.34786111
85regulation of postsynaptic membrane potential (GO:0060078)2.34411087
86regulation of synaptic plasticity (GO:0048167)2.33456821
87neuromuscular process controlling posture (GO:0050884)2.33263171
88glycine transport (GO:0015816)2.32901465
89positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.32863248
90cell communication by electrical coupling (GO:0010644)2.32654451
91neuromuscular process controlling balance (GO:0050885)2.32593164
92response to epinephrine (GO:0071871)2.32427108
93behavioral response to cocaine (GO:0048148)2.32111156
94regulation of early endosome to late endosome transport (GO:2000641)2.31938613
95alanine transport (GO:0032328)2.30704952
96neurotransmitter uptake (GO:0001504)2.27083711
97organelle transport along microtubule (GO:0072384)2.26910804
98negative regulation of protein localization to cell surface (GO:2000009)2.26505664
99prepulse inhibition (GO:0060134)2.26418190
100negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.26097959
101positive regulation of membrane potential (GO:0045838)2.25700617
102regulation of neurotransmitter secretion (GO:0046928)2.25454968
103regulation of female receptivity (GO:0045924)2.25414008
104positive regulation of cellular response to insulin stimulus (GO:1900078)2.25105209
105cerebellar Purkinje cell layer development (GO:0021680)2.24139603
106negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.24038182
107long-term synaptic potentiation (GO:0060291)2.24027015
108synapse organization (GO:0050808)2.23107742
109negative regulation of heart contraction (GO:0045822)2.21146462
110regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.21114587
111regulation of dendritic spine development (GO:0060998)2.21093372
112regulation of synaptic transmission, glutamatergic (GO:0051966)2.20807351
113positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.19749655
114suckling behavior (GO:0001967)2.19485265
115cerebellar Purkinje cell differentiation (GO:0021702)2.19208548
116G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.19015604
117positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.18853353
118positive regulation of cellular amide metabolic process (GO:0034250)2.18688780
119negative regulation of amino acid transport (GO:0051956)2.18136205
120synapse assembly (GO:0007416)2.18059572
121extracellular fibril organization (GO:0043206)2.17188153
122amino acid import (GO:0043090)2.16983673
123adenosine receptor signaling pathway (GO:0001973)2.16909407
124cell communication involved in cardiac conduction (GO:0086065)2.16888031
125regulation of ARF protein signal transduction (GO:0032012)2.15224282
126potassium ion import (GO:0010107)2.15167652
127female mating behavior (GO:0060180)2.14578917
128macroautophagy (GO:0016236)2.14394928
129multi-organism reproductive behavior (GO:0044705)2.13337651
130cerebellar granule cell differentiation (GO:0021707)2.13070936
131regulation of beta-amyloid formation (GO:1902003)2.13020648
132positive regulation of potassium ion transport (GO:0043268)2.12833157
133positive regulation of synapse maturation (GO:0090129)2.12132444
134regulation of glutamate secretion (GO:0014048)2.11995518
135negative regulation of protein localization to plasma membrane (GO:1903077)2.11882631
136cortical actin cytoskeleton organization (GO:0030866)2.11784810
137regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.11084824
138membrane depolarization during action potential (GO:0086010)2.10843849
139regulation of integrin-mediated signaling pathway (GO:2001044)2.10839720
140regulation of calcium ion transmembrane transporter activity (GO:1901019)2.10780504
141regulation of calcium ion transmembrane transport (GO:1903169)2.10780504
142positive regulation of synaptic transmission, GABAergic (GO:0032230)2.10529095
143long term synaptic depression (GO:0060292)2.10175634
144membrane depolarization (GO:0051899)2.10081282
145regulation of neurotransmitter transport (GO:0051588)2.08824021
146synaptic vesicle endocytosis (GO:0048488)2.08745571
147regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.08660590
148potassium ion homeostasis (GO:0055075)2.08464380
149presynaptic membrane assembly (GO:0097105)2.08323820
150regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.08072618
151innervation (GO:0060384)2.07827060
152protein targeting to plasma membrane (GO:0072661)2.07739218
153cellular response to glucagon stimulus (GO:0071377)2.07664044
154vesicle docking involved in exocytosis (GO:0006904)2.07478481
155platelet aggregation (GO:0070527)2.06853731
156cell differentiation in hindbrain (GO:0021533)2.06465844

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.97689228
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.64493750
3GBX2_23144817_ChIP-Seq_PC3_Human2.61657524
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60881914
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42112662
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.34559760
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.34559760
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.24357862
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24000416
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22683910
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.19732195
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14015693
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12566257
14EZH2_27304074_Chip-Seq_ESCs_Mouse1.95941573
15EED_16625203_ChIP-ChIP_MESCs_Mouse1.93328169
16REST_21632747_ChIP-Seq_MESCs_Mouse1.88719618
17SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81345220
18EZH2_27294783_Chip-Seq_ESCs_Mouse1.80456729
19DROSHA_22980978_ChIP-Seq_HELA_Human1.75282942
20TAF15_26573619_Chip-Seq_HEK293_Human1.75098746
21SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.74910573
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73684466
23RARB_27405468_Chip-Seq_BRAIN_Mouse1.72071723
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71318046
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.70347315
26AR_21572438_ChIP-Seq_LNCaP_Human1.66719666
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.64868150
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.58288513
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57863181
30* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.55515211
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54103115
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.50345807
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48647820
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.47637520
35SMAD4_21799915_ChIP-Seq_A2780_Human1.47578129
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47577481
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.46366033
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44875810
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.40545179
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40206082
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.38459770
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37266336
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.35437978
44GATA1_19941826_ChIP-Seq_K562_Human1.34568893
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33844319
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.31287208
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30288861
48ZNF274_21170338_ChIP-Seq_K562_Hela1.29804435
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28271626
50P300_19829295_ChIP-Seq_ESCs_Human1.27288812
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26570389
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25066528
53AR_25329375_ChIP-Seq_VCAP_Human1.23725534
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.23676878
55ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.23525509
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22825924
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22346771
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.21231542
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21094779
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20972445
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20669047
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20017050
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19470497
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19470497
65ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16731873
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15896948
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.13683705
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13109624
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12940466
70GATA2_19941826_ChIP-Seq_K562_Human1.12783347
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.12200747
72BCAT_22108803_ChIP-Seq_LS180_Human1.11454344
73AHR_22903824_ChIP-Seq_MCF-7_Human1.09837031
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.09631935
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09500538
76* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09231001
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.09189380
78GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08982392
79LXR_22158963_ChIP-Seq_LIVER_Mouse1.08698495
80STAT3_23295773_ChIP-Seq_U87_Human1.08555719
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08300983
82BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08200304
83CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07974416
84* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07483972
85RXR_22158963_ChIP-Seq_LIVER_Mouse1.07054709
86TP53_18474530_ChIP-ChIP_U2OS_Human1.06828720
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06323386
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06293486
89GATA1_19941827_ChIP-Seq_MEL_Mouse1.05171023
90RXR_22108803_ChIP-Seq_LS180_Human1.04935406
91CLOCK_20551151_ChIP-Seq_293T_Human1.03325250
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03199323
93* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02803567
94NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02156750
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01993300
96RING1B_27294783_Chip-Seq_ESCs_Mouse1.01429533
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00842450
98MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00127743
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99898108
100CBX2_27304074_Chip-Seq_ESCs_Mouse0.99199933
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98979411
102SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98934047
103CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98691537
104KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98524675
105TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98000757
106AR_19668381_ChIP-Seq_PC3_Human0.97788974
107ESR1_20079471_ChIP-ChIP_T-47D_Human0.96776900
108TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96457125
109TP53_16413492_ChIP-PET_HCT116_Human0.96412831
110RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96354532
111WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95361343
112ESR2_21235772_ChIP-Seq_MCF-7_Human0.94728813
113ER_23166858_ChIP-Seq_MCF-7_Human0.94064415
114RUNX2_22187159_ChIP-Seq_PCA_Human0.93366426
115CJUN_26792858_Chip-Seq_BT549_Human0.92245912
116FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.91913449
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91804789
118EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91455414
119* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90676621
120BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89676214
121SMAD4_21741376_ChIP-Seq_HESCs_Human0.89638994
122GATA1_19941827_ChIP-Seq_MEL86_Mouse0.89486591
123SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89030836
124* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89021366
125KDM2B_26808549_Chip-Seq_K562_Human0.88142059
126SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87429103
127VDR_22108803_ChIP-Seq_LS180_Human0.86938574
128SMAD4_21741376_ChIP-Seq_EPCs_Human0.85077949
129TCF4_23295773_ChIP-Seq_U87_Human0.84752423
130IGF1R_20145208_ChIP-Seq_DFB_Human0.84655416
131ZFP281_18757296_ChIP-ChIP_E14_Mouse0.83435412
132NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.82995538
133TCF4_18268006_ChIP-ChIP_LS174T_Human0.82457099
134NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78814795
135CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.78526763
136VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.78059810
137NANOG_18555785_Chip-Seq_ESCs_Mouse0.77841474
138PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77194477
139TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77027413
140TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76935720
141PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76931604

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.56882275
2MP0003880_abnormal_central_pattern3.52992665
3MP0003635_abnormal_synaptic_transmissio3.17428993
4MP0004270_analgesia3.00678685
5MP0005464_abnormal_platelet_physiology2.78416453
6MP0002837_dystrophic_cardiac_calcinosis2.60253359
7MP0009745_abnormal_behavioral_response2.51226444
8MP0009780_abnormal_chondrocyte_physiolo2.49711702
9MP0002063_abnormal_learning/memory/cond2.47958900
10MP0002064_seizures2.41146820
11MP0000569_abnormal_digit_pigmentation2.38452893
12MP0004510_myositis2.36252570
13MP0009046_muscle_twitch2.35612696
14MP0001501_abnormal_sleep_pattern2.27234321
15MP0000013_abnormal_adipose_tissue2.22909041
16MP0003329_amyloid_beta_deposits2.16153331
17MP0001440_abnormal_grooming_behavior2.11130016
18MP0002909_abnormal_adrenal_gland2.09156824
19MP0002734_abnormal_mechanical_nocicepti2.05149170
20MP0008260_abnormal_autophagy2.02241899
21MP0008004_abnormal_stomach_pH2.01863678
22MP0001968_abnormal_touch/_nociception2.01814658
23MP0002572_abnormal_emotion/affect_behav1.99380307
24MP0005409_darkened_coat_color1.99044304
25MP0002272_abnormal_nervous_system1.91698589
26MP0003705_abnormal_hypodermis_morpholog1.90726154
27MP0001486_abnormal_startle_reflex1.87069072
28MP0003656_abnormal_erythrocyte_physiolo1.82758092
29MP0003566_abnormal_cell_adhesion1.82447371
30MP0004130_abnormal_muscle_cell1.80462879
31MP0002139_abnormal_hepatobiliary_system1.77690811
32MP0006276_abnormal_autonomic_nervous1.77231560
33MP0005423_abnormal_somatic_nervous1.76885812
34MP0003828_pulmonary_edema1.74925159
35MP0003091_abnormal_cell_migration1.72768088
36MP0001958_emphysema1.67929826
37MP0002733_abnormal_thermal_nociception1.65308734
38MP0002332_abnormal_exercise_endurance1.64671850
39MP0008438_abnormal_cutaneous_collagen1.62426111
40MP0003303_peritoneal_inflammation1.58612492
41MP0005535_abnormal_body_temperature1.58020717
42MP0010234_abnormal_vibrissa_follicle1.57279240
43MP0004084_abnormal_cardiac_muscle1.57061363
44MP0000751_myopathy1.56493574
45MP0002067_abnormal_sensory_capabilities1.47094881
46MP0001970_abnormal_pain_threshold1.47070210
47MP0003195_calcinosis1.45848013
48MP0002736_abnormal_nociception_after1.44346825
49MP0004145_abnormal_muscle_electrophysio1.44166241
50MP0005386_behavior/neurological_phenoty1.43713448
51MP0004924_abnormal_behavior1.43713448
52MP0002822_catalepsy1.43705769
53MP0004858_abnormal_nervous_system1.33647091
54MP0002184_abnormal_innervation1.31294125
55MP0003879_abnormal_hair_cell1.30495501
56MP0002735_abnormal_chemical_nociception1.29112960
57MP0003300_gastrointestinal_ulcer1.28675466
58MP0005360_urolithiasis1.27593683
59MP0005275_abnormal_skin_tensile1.26116994
60MP0000778_abnormal_nervous_system1.23453127
61MP0005085_abnormal_gallbladder_physiolo1.22542572
62MP0003724_increased_susceptibility_to1.21504184
63MP0004043_abnormal_pH_regulation1.20996330
64MP0000747_muscle_weakness1.20303025
65MP0000749_muscle_degeneration1.19767376
66MP0003633_abnormal_nervous_system1.18365216
67MP0003787_abnormal_imprinting1.18292870
68MP0008569_lethality_at_weaning1.18057335
69MP0000604_amyloidosis1.17393143
70MP0002557_abnormal_social/conspecific_i1.16767412
71MP0001984_abnormal_olfaction1.16651207
72MP0003690_abnormal_glial_cell1.15873475
73MP0004885_abnormal_endolymph1.14672757
74MP0002066_abnormal_motor_capabilities/c1.13941632
75MP0002972_abnormal_cardiac_muscle1.12562831
76MP0002876_abnormal_thyroid_physiology1.11252306
77MP0004811_abnormal_neuron_physiology1.10618812
78MP0004215_abnormal_myocardial_fiber1.09200148
79MP0003279_aneurysm1.09142706
80MP0010329_abnormal_lipoprotein_level1.08913636
81MP0000955_abnormal_spinal_cord1.06587480
82MP0008875_abnormal_xenobiotic_pharmacok1.06331779
83MP0005365_abnormal_bile_salt1.04208320
84MP0005187_abnormal_penis_morphology1.03131007
85MP0000003_abnormal_adipose_tissue1.02517709
86MP0004185_abnormal_adipocyte_glucose1.01473675
87MP0004484_altered_response_of1.00910675
88MP0004883_abnormal_blood_vessel1.00217424
89MP0001851_eye_inflammation0.99730792
90MP0005645_abnormal_hypothalamus_physiol0.99699442
91MP0002090_abnormal_vision0.97626189
92MP0001177_atelectasis0.97363082
93MP0001299_abnormal_eye_distance/0.96339465
94MP0006138_congestive_heart_failure0.96131342
95MP0004036_abnormal_muscle_relaxation0.95999631
96MP0003172_abnormal_lysosome_physiology0.95998404
97MP0002882_abnormal_neuron_morphology0.93883691
98MP0001879_abnormal_lymphatic_vessel0.93475532
99MP0005620_abnormal_muscle_contractility0.93027174
100MP0002118_abnormal_lipid_homeostasis0.91428578
101MP0005388_respiratory_system_phenotype0.91193578
102MP0002133_abnormal_respiratory_system0.91193578
103MP0005666_abnormal_adipose_tissue0.90446131
104MP0003631_nervous_system_phenotype0.90354801
105MP0005375_adipose_tissue_phenotype0.89899843
106MP0010386_abnormal_urinary_bladder0.89792892
107MP0004087_abnormal_muscle_fiber0.87545236
108MP0002069_abnormal_eating/drinking_beha0.87502830
109MP0000759_abnormal_skeletal_muscle0.87470261
110MP0002877_abnormal_melanocyte_morpholog0.87454875
111MP0002971_abnormal_brown_adipose0.87023664
112MP0005646_abnormal_pituitary_gland0.86743064
113MP0003632_abnormal_nervous_system0.85957775
114MP0003646_muscle_fatigue0.85754549
115MP0004085_abnormal_heartbeat0.85516909
116MP0005332_abnormal_amino_acid0.85000774
117MP0000465_gastrointestinal_hemorrhage0.84805871
118MP0003183_abnormal_peptide_metabolism0.84790249
119MP0005623_abnormal_meninges_morphology0.84468685
120MP0003453_abnormal_keratinocyte_physiol0.84279859
121MP0008961_abnormal_basal_metabolism0.82737360
122MP0002078_abnormal_glucose_homeostasis0.82421399
123MP0003191_abnormal_cellular_cholesterol0.82421377
124MP0000343_altered_response_to0.81705825
125MP0008874_decreased_physiological_sensi0.81495534
126MP0001502_abnormal_circadian_rhythm0.81153370
127MP0001905_abnormal_dopamine_level0.80763649
128MP0005167_abnormal_blood-brain_barrier0.79770800
129MP0002295_abnormal_pulmonary_circulatio0.79112767
130MP0003283_abnormal_digestive_organ0.78398505
131MP0001188_hyperpigmentation0.77110417
132MP0003075_altered_response_to0.76982666
133MP0004142_abnormal_muscle_tone0.76845073
134MP0003634_abnormal_glial_cell0.76114898
135MP0001529_abnormal_vocalization0.75920197
136MP0004272_abnormal_basement_membrane0.74125677
137MP0005448_abnormal_energy_balance0.73046961
138MP0000920_abnormal_myelination0.72002300
139MP0001765_abnormal_ion_homeostasis0.71924511
140MP0002229_neurodegeneration0.71768847
141MP0004742_abnormal_vestibular_system0.70921834
142MP0000230_abnormal_systemic_arterial0.70202277
143MP0003252_abnormal_bile_duct0.69919189

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.50219999
2Visual hallucinations (HP:0002367)4.43530848
3Focal seizures (HP:0007359)4.19681160
4Increased mean platelet volume (HP:0011877)4.11208704
5Myokymia (HP:0002411)3.90543319
6Abnormal platelet volume (HP:0011876)3.76547110
7Menorrhagia (HP:0000132)3.69361324
8Prolonged bleeding time (HP:0003010)3.57221653
9Atonic seizures (HP:0010819)3.53175983
10Absence seizures (HP:0002121)3.44248816
11Generalized tonic-clonic seizures (HP:0002069)3.28355386
12Cerebral inclusion bodies (HP:0100314)3.11359019
13Dialeptic seizures (HP:0011146)3.11194241
14Neurofibrillary tangles (HP:0002185)3.04877281
15Action tremor (HP:0002345)2.95461089
16Diplopia (HP:0000651)2.85238697
17Abnormality of binocular vision (HP:0011514)2.85238697
18Gingival bleeding (HP:0000225)2.81273237
19Supranuclear gaze palsy (HP:0000605)2.77511435
20Arterial tortuosity (HP:0005116)2.77077385
21Pheochromocytoma (HP:0002666)2.72455913
22Obstructive sleep apnea (HP:0002870)2.67322172
23Epileptic encephalopathy (HP:0200134)2.66505587
24Vascular tortuosity (HP:0004948)2.66009504
25Febrile seizures (HP:0002373)2.60457864
26Purpura (HP:0000979)2.58209271
27Progressive cerebellar ataxia (HP:0002073)2.57274011
28Anxiety (HP:0000739)2.56255695
29Insidious onset (HP:0003587)2.54591472
30Termporal pattern (HP:0011008)2.54591472
31Type 1 muscle fiber predominance (HP:0003803)2.49544399
32Hyperventilation (HP:0002883)2.48694792
33Papillary thyroid carcinoma (HP:0002895)2.48627973
34Epistaxis (HP:0000421)2.48494913
35Lower limb amyotrophy (HP:0007210)2.44759440
36Abnormality of skeletal muscle fiber size (HP:0012084)2.40271219
37Impaired social interactions (HP:0000735)2.39629127
38Abnormal social behavior (HP:0012433)2.39629127
39Poor eye contact (HP:0000817)2.35202225
40Dysdiadochokinesis (HP:0002075)2.33004990
41Depression (HP:0000716)2.32623336
42Oligomenorrhea (HP:0000876)2.32291553
43Abnormal eating behavior (HP:0100738)2.32119855
44Spontaneous hematomas (HP:0007420)2.32078551
45Exercise-induced myalgia (HP:0003738)2.30981474
46Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.29553777
47Neuroendocrine neoplasm (HP:0100634)2.29517800
48Nemaline bodies (HP:0003798)2.29502154
49Protrusio acetabuli (HP:0003179)2.25574989
50Mutism (HP:0002300)2.24172817
51Muscle fiber inclusion bodies (HP:0100299)2.23665580
52Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.22113708
53Mitral stenosis (HP:0001718)2.21011277
54Ankle clonus (HP:0011448)2.20819824
55Intention tremor (HP:0002080)2.20809306
56Distal lower limb amyotrophy (HP:0008944)2.20598291
57Aortic aneurysm (HP:0004942)2.20418723
58Status epilepticus (HP:0002133)2.19903548
59Amblyopia (HP:0000646)2.19785272
60Ketoacidosis (HP:0001993)2.19067352
61Subaortic stenosis (HP:0001682)2.18949300
62Abnormality of the left ventricular outflow tract (HP:0011103)2.18949300
63Broad-based gait (HP:0002136)2.18689846
64Torticollis (HP:0000473)2.17671268
65Dysmetria (HP:0001310)2.17638078
66Gout (HP:0001997)2.15685159
67Papilledema (HP:0001085)2.14970386
68Impaired vibration sensation in the lower limbs (HP:0002166)2.14013076
69Postural instability (HP:0002172)2.13657798
70Global brain atrophy (HP:0002283)2.12261105
71Agitation (HP:0000713)2.09275929
72Progressive inability to walk (HP:0002505)2.08492904
73Petechiae (HP:0000967)2.07982634
74Fetal akinesia sequence (HP:0001989)2.06363319
75Drooling (HP:0002307)2.05231252
76Excessive salivation (HP:0003781)2.05231252
77Distal lower limb muscle weakness (HP:0009053)2.02728296
78Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.01693067
79Hyperlipoproteinemia (HP:0010980)1.98334253
80Foot dorsiflexor weakness (HP:0009027)1.97492995
81Increased variability in muscle fiber diameter (HP:0003557)1.97199393
82Ventricular fibrillation (HP:0001663)1.96822498
83Overgrowth (HP:0001548)1.96439141
84Poikilocytosis (HP:0004447)1.95319439
85Hyperthyroidism (HP:0000836)1.95256396
86Slow saccadic eye movements (HP:0000514)1.93183034
87Focal dystonia (HP:0004373)1.92885623
88Abnormality of the Achilles tendon (HP:0005109)1.92469620
89Truncal ataxia (HP:0002078)1.90573274
90Urinary urgency (HP:0000012)1.90425751
91Epileptiform EEG discharges (HP:0011182)1.89940074
92Hypercortisolism (HP:0001578)1.89801395
93EEG with generalized epileptiform discharges (HP:0011198)1.89546214
94Cerebral hemorrhage (HP:0001342)1.87607468
95Resting tremor (HP:0002322)1.86945476
96Ketosis (HP:0001946)1.86652456
97Degeneration of the lateral corticospinal tracts (HP:0002314)1.86353706
98Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.86353706
99Abnormality of the foot musculature (HP:0001436)1.85105886
100Urinary bladder sphincter dysfunction (HP:0002839)1.84921809
101Achilles tendon contracture (HP:0001771)1.84770093
102Craniofacial dystonia (HP:0012179)1.84338877
103Abnormality of the corticospinal tract (HP:0002492)1.84042961
104Buphthalmos (HP:0000557)1.83820963
105Generalized myoclonic seizures (HP:0002123)1.83339323
106Skin nodule (HP:0200036)1.83252497
107Tetraparesis (HP:0002273)1.82619834
108Rapidly progressive (HP:0003678)1.82363108
109Megalencephaly (HP:0001355)1.80988505
110Hyporeflexia of lower limbs (HP:0002600)1.80364811
111Hypsarrhythmia (HP:0002521)1.80228040
112Hemiplegia (HP:0002301)1.80178744
113Conjunctival telangiectasia (HP:0000524)1.79283624
114Frequent falls (HP:0002359)1.79187394
115Muscle hypertrophy of the lower extremities (HP:0008968)1.78497990
116Bradykinesia (HP:0002067)1.77407180
117Difficulty running (HP:0009046)1.76640849
118Deep venous thrombosis (HP:0002625)1.76386554
119Xanthomatosis (HP:0000991)1.76175989
120Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75981449
121Postural tremor (HP:0002174)1.74310484
122Sudden death (HP:0001699)1.74194744
123Decreased motor nerve conduction velocity (HP:0003431)1.74147917
124Lower limb muscle weakness (HP:0007340)1.74006316
125Aortic dissection (HP:0002647)1.73245252
126Limb dystonia (HP:0002451)1.73148326
127Cholecystitis (HP:0001082)1.73141270
128Abnormal gallbladder physiology (HP:0012438)1.73141270
129Neuronal loss in central nervous system (HP:0002529)1.72605492
130Bundle branch block (HP:0011710)1.71898221
131Polyphagia (HP:0002591)1.71678379
132Akinesia (HP:0002304)1.71218345
133Slow progression (HP:0003677)1.69438206
134Aplasia involving bones of the extremities (HP:0009825)1.68093707
135Aplasia involving bones of the upper limbs (HP:0009823)1.68093707
136Aplasia of the phalanges of the hand (HP:0009802)1.68093707
137Abnormal atrioventricular conduction (HP:0005150)1.67900481
138Impaired platelet aggregation (HP:0003540)1.67635791
139Abnormal platelet function (HP:0011869)1.67635791
140Peritonitis (HP:0002586)1.67622433
141Testicular neoplasm (HP:0010788)1.67006861
142Dysmetric saccades (HP:0000641)1.66974859
143Heart block (HP:0012722)1.66643018
144Muscle fiber splitting (HP:0003555)1.65442473
145Rigidity (HP:0002063)1.65349089
146Vertebral arch anomaly (HP:0008438)1.64942364
147Gaze-evoked nystagmus (HP:0000640)1.64231130
148Atrioventricular block (HP:0001678)1.64161053
149Spastic gait (HP:0002064)1.63950894
150Scanning speech (HP:0002168)1.63775344
151Myotonia (HP:0002486)1.63616839
152Calf muscle hypertrophy (HP:0008981)1.63584408
153Bronchomalacia (HP:0002780)1.63531270
154Hyperglycinemia (HP:0002154)1.63341897
155Tetraplegia (HP:0002445)1.62885210
156Abnormality of aromatic amino acid family metabolism (HP:0004338)1.62194893
157Increased circulating renin level (HP:0000848)1.61489687

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.45004189
2MAP3K93.28557467
3EPHA42.96436270
4MAP3K42.61919886
5MARK12.44812928
6KSR22.32464904
7MAP2K42.29315575
8NTRK12.17134124
9MINK12.15302504
10DAPK22.10520033
11PAK61.96630757
12PRKD31.86311243
13MAP2K71.80211860
14RIPK41.72077331
15PRPF4B1.70143816
16MAP3K21.69930451
17MAP3K121.63931947
18ARAF1.55286944
19LATS21.52259200
20CAMKK11.49381067
21GRK51.47619274
22PAK31.43877439
23PHKG21.43810576
24PHKG11.43810576
25NTRK21.40214581
26PNCK1.39059317
27FRK1.37271656
28MAP2K31.33633930
29KSR11.32723189
30MYLK1.31930821
31CDK51.30154326
32TTN1.29983652
33TRIB31.28281481
34OXSR11.23240617
35PLK21.16782207
36WNK41.16444118
37RET1.15888306
38FER1.15353021
39FGFR21.14247877
40PINK11.13269772
41STK391.12541110
42CAMKK21.09198835
43STK381.06850445
44MARK21.06739349
45CAMK1G1.06706625
46MAP3K111.06296494
47TYRO31.05838583
48MAP3K31.01357295
49PRKCG1.01009372
50BMX1.00544646
51PTK2B0.99766952
52CAMK2A0.99725658
53MAP2K10.99178367
54STK110.97972235
55PDK40.97548571
56PDK30.97548571
57DDR20.92675960
58PRKCH0.91452597
59CSNK1G20.91367155
60MAP3K50.89791948
61MAP3K130.89613645
62STK240.89245896
63TAOK20.88703802
64GRK60.87877797
65WNK30.87383969
66SGK2230.83869959
67SGK4940.83869959
68MAP3K10.83062359
69PDGFRA0.81264767
70PDPK10.81176506
71CASK0.80994403
72OBSCN0.80859761
73DMPK0.80003719
74TAOK10.77775520
75INSRR0.74758815
76CAMK2B0.73735361
77ROCK20.73393210
78PRKCE0.72545429
79RIPK10.71967892
80CAMK2G0.71357818
81PDGFRB0.70885108
82MAPK130.68751885
83IRAK20.68741118
84SIK20.68515573
85YES10.67163270
86DYRK1B0.67070922
87CAMK2D0.65256628
88JAK10.64700139
89LMTK20.64590708
90SGK10.63063757
91WNK10.62234224
92UHMK10.62164532
93CDK140.61707568
94BMPR20.61321314
95PDK10.61109979
96ERBB20.60654261
97FES0.59158461
98PRKCZ0.58754945
99CAMK10.58420242
100PDK20.58133717
101DAPK10.56871255
102SGK30.55591916
103FGR0.54838995
104DYRK1A0.53429784
105NME10.53357928
106TESK10.53080195
107AKT30.52732678
108MAPK70.52111414
109EPHB10.51608749
110MOS0.51578945
111NEK90.51268837
112JAK20.50641498
113CDK150.50485460
114CAMK1D0.50469702
115PIK3CG0.50459703
116SGK20.50390691
117RAF10.49838898
118SCYL20.49692167
119FYN0.49277552
120ZAP700.48748749
121TRPM70.48657276
122CDK180.48248864
123FGFR30.47498328
124MAP3K70.46160811
125RPS6KA30.45669481
126PRKAA10.45514898
127PTK20.44679622
128ABL20.43451300
129MAPK120.43376356
130MST1R0.43181496
131MAP3K60.43087276

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.32468921
2Nicotine addiction_Homo sapiens_hsa050332.31772938
3Synaptic vesicle cycle_Homo sapiens_hsa047212.28633343
4GABAergic synapse_Homo sapiens_hsa047271.99794282
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.84307704
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82943380
7Long-term potentiation_Homo sapiens_hsa047201.77866463
8Amphetamine addiction_Homo sapiens_hsa050311.72565730
9Circadian entrainment_Homo sapiens_hsa047131.71034023
10Olfactory transduction_Homo sapiens_hsa047401.70425334
11Glutamatergic synapse_Homo sapiens_hsa047241.63418810
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61941731
13Morphine addiction_Homo sapiens_hsa050321.60720104
14Salivary secretion_Homo sapiens_hsa049701.57238991
15Insulin secretion_Homo sapiens_hsa049111.56532686
16Platelet activation_Homo sapiens_hsa046111.55214695
17Dopaminergic synapse_Homo sapiens_hsa047281.50734016
18Butanoate metabolism_Homo sapiens_hsa006501.49879116
19Gastric acid secretion_Homo sapiens_hsa049711.46515258
20Renin secretion_Homo sapiens_hsa049241.45939568
21Collecting duct acid secretion_Homo sapiens_hsa049661.37530824
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36185957
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.35998592
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27694623
25Cholinergic synapse_Homo sapiens_hsa047251.27573698
26Taste transduction_Homo sapiens_hsa047421.27271392
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26368427
28Cocaine addiction_Homo sapiens_hsa050301.24104030
29Arginine biosynthesis_Homo sapiens_hsa002201.22718059
30Long-term depression_Homo sapiens_hsa047301.19708304
31Oxytocin signaling pathway_Homo sapiens_hsa049211.16946295
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.15741146
33Serotonergic synapse_Homo sapiens_hsa047261.12778305
34Propanoate metabolism_Homo sapiens_hsa006401.11188542
35Neurotrophin signaling pathway_Homo sapiens_hsa047221.10758123
36Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.09878285
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08189427
38GnRH signaling pathway_Homo sapiens_hsa049121.07646700
39Endometrial cancer_Homo sapiens_hsa052131.07522231
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06391966
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06338241
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05989217
43Focal adhesion_Homo sapiens_hsa045101.03219275
44ECM-receptor interaction_Homo sapiens_hsa045121.02753523
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01767330
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.01227220
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01091371
48Bile secretion_Homo sapiens_hsa049761.00815617
49Calcium signaling pathway_Homo sapiens_hsa040201.00471414
50Type II diabetes mellitus_Homo sapiens_hsa049300.99554966
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98764823
52Non-small cell lung cancer_Homo sapiens_hsa052230.97977553
53Cardiac muscle contraction_Homo sapiens_hsa042600.97634443
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97470517
55Gap junction_Homo sapiens_hsa045400.94985346
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94839643
57Endocytosis_Homo sapiens_hsa041440.93377311
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93186603
59PPAR signaling pathway_Homo sapiens_hsa033200.91733265
60Amoebiasis_Homo sapiens_hsa051460.90706309
61Estrogen signaling pathway_Homo sapiens_hsa049150.90631281
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90585669
63Rap1 signaling pathway_Homo sapiens_hsa040150.88939766
64Dorso-ventral axis formation_Homo sapiens_hsa043200.88422917
65Inositol phosphate metabolism_Homo sapiens_hsa005620.87786112
66Vibrio cholerae infection_Homo sapiens_hsa051100.87066211
67Circadian rhythm_Homo sapiens_hsa047100.86156895
68cAMP signaling pathway_Homo sapiens_hsa040240.86137259
69Chemokine signaling pathway_Homo sapiens_hsa040620.85794371
70Fatty acid metabolism_Homo sapiens_hsa012120.85714933
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83000561
72Ras signaling pathway_Homo sapiens_hsa040140.82363006
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82297589
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82273212
75Sulfur metabolism_Homo sapiens_hsa009200.82148357
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82100812
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81525553
78Prolactin signaling pathway_Homo sapiens_hsa049170.81354619
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81046512
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80735957
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.80406383
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79994297
83Glioma_Homo sapiens_hsa052140.79647113
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79571710
85Pancreatic cancer_Homo sapiens_hsa052120.79184012
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.78354013
87Fatty acid degradation_Homo sapiens_hsa000710.78174793
88Fatty acid biosynthesis_Homo sapiens_hsa000610.77962462
89MAPK signaling pathway_Homo sapiens_hsa040100.77561159
90Glucagon signaling pathway_Homo sapiens_hsa049220.76997331
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.75928031
92Pancreatic secretion_Homo sapiens_hsa049720.75336860
93Thyroid hormone synthesis_Homo sapiens_hsa049180.75295547
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74746557
95Chronic myeloid leukemia_Homo sapiens_hsa052200.74459179
96FoxO signaling pathway_Homo sapiens_hsa040680.71166284
97Dilated cardiomyopathy_Homo sapiens_hsa054140.70673889
98Melanogenesis_Homo sapiens_hsa049160.69876096
99mTOR signaling pathway_Homo sapiens_hsa041500.69012214
100Proteoglycans in cancer_Homo sapiens_hsa052050.68692128
101B cell receptor signaling pathway_Homo sapiens_hsa046620.68255778
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67559630
103Alzheimers disease_Homo sapiens_hsa050100.66843105
104Adherens junction_Homo sapiens_hsa045200.66260831
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64165488
106Axon guidance_Homo sapiens_hsa043600.63652628
107Oxidative phosphorylation_Homo sapiens_hsa001900.63444881
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63120600
109Pyruvate metabolism_Homo sapiens_hsa006200.62597749
110ErbB signaling pathway_Homo sapiens_hsa040120.61498699
111Tryptophan metabolism_Homo sapiens_hsa003800.59145728
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58113667
113Tight junction_Homo sapiens_hsa045300.57676104
114Insulin signaling pathway_Homo sapiens_hsa049100.57588038
115Phenylalanine metabolism_Homo sapiens_hsa003600.56991839
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.56668668
117Osteoclast differentiation_Homo sapiens_hsa043800.55924977
118Prion diseases_Homo sapiens_hsa050200.54553510
119Glycerolipid metabolism_Homo sapiens_hsa005610.53977104
120beta-Alanine metabolism_Homo sapiens_hsa004100.53320923
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52888117
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.52107463
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51516839
124Renal cell carcinoma_Homo sapiens_hsa052110.48863846
125AMPK signaling pathway_Homo sapiens_hsa041520.48415444
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47916599
127HIF-1 signaling pathway_Homo sapiens_hsa040660.47153428
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47007566
129Choline metabolism in cancer_Homo sapiens_hsa052310.45431773
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.44608301
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44347053
132Fatty acid elongation_Homo sapiens_hsa000620.42851095
133Parkinsons disease_Homo sapiens_hsa050120.42847257
134Starch and sucrose metabolism_Homo sapiens_hsa005000.42574868
135Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41263220
136Ovarian steroidogenesis_Homo sapiens_hsa049130.40636413
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40135590
138Peroxisome_Homo sapiens_hsa041460.39701886
139VEGF signaling pathway_Homo sapiens_hsa043700.39161969

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »