RNF111

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.16982773
2regulation of DNA methylation (GO:0044030)4.04354073
3positive regulation of gamma-delta T cell activation (GO:0046645)3.96492040
4regulation of female gonad development (GO:2000194)3.88694410
5protein targeting to Golgi (GO:0000042)3.83976924
6modulation by symbiont of host immune response (GO:0052553)3.80386369
7positive regulation by symbiont of host defense response (GO:0052509)3.80386369
8modulation by symbiont of host defense response (GO:0052031)3.80386369
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.80386369
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.80386369
11positive regulation by organism of defense response of other organism involved in symbiotic interact3.80386369
12retrograde transport, vesicle recycling within Golgi (GO:0000301)3.77057772
13establishment of protein localization to Golgi (GO:0072600)3.76179174
14nuclear pore complex assembly (GO:0051292)3.71634345
15regulation of acrosome reaction (GO:0060046)3.66266901
16histone H3-K9 demethylation (GO:0033169)3.63477987
17phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.53474463
18mitotic sister chromatid cohesion (GO:0007064)3.46741793
19positive regulation of humoral immune response (GO:0002922)3.40859387
20negative regulation of histone methylation (GO:0031061)3.33075163
21oocyte development (GO:0048599)3.32529750
22nerve growth factor signaling pathway (GO:0038180)3.31999771
23multicellular organism reproduction (GO:0032504)3.25654102
24response to muramyl dipeptide (GO:0032495)3.21494472
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.18052782
26negative regulation of cell killing (GO:0031342)3.18052782
27vesicle transport along microtubule (GO:0047496)3.13994358
28monoubiquitinated protein deubiquitination (GO:0035520)3.11553194
29immunoglobulin mediated immune response (GO:0016064)3.10722667
30nuclear pore organization (GO:0006999)3.10569163
31regulation of gamma-delta T cell activation (GO:0046643)3.08693637
32regulation of NFAT protein import into nucleus (GO:0051532)3.07782429
33histone lysine demethylation (GO:0070076)3.00641928
34neutrophil mediated immunity (GO:0002446)2.98859376
35pore complex assembly (GO:0046931)2.97360793
36protein K11-linked deubiquitination (GO:0035871)2.95738958
37DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.92481201
38histone H3-K4 trimethylation (GO:0080182)2.92266450
39regulation of B cell receptor signaling pathway (GO:0050855)2.91503089
40histone demethylation (GO:0016577)2.91475871
41dosage compensation (GO:0007549)2.91453516
42response to peptidoglycan (GO:0032494)2.90894680
43cytoplasmic mRNA processing body assembly (GO:0033962)2.88175865
44peptidyl-lysine trimethylation (GO:0018023)2.87520204
45regulation of interferon-beta biosynthetic process (GO:0045357)2.85526183
46regulation of gamma-delta T cell differentiation (GO:0045586)2.85102803
47regulation of RNA export from nucleus (GO:0046831)2.84783292
48regulation of interleukin-12 biosynthetic process (GO:0045075)2.83466159
49detection of molecule of bacterial origin (GO:0032490)2.81860295
50regulation of spindle organization (GO:0090224)2.80474698
51regulation of clathrin-mediated endocytosis (GO:2000369)2.79054272
52protein localization to kinetochore (GO:0034501)2.78839850
53mitotic metaphase plate congression (GO:0007080)2.78432933
54positive thymic T cell selection (GO:0045059)2.76635196
55NIK/NF-kappaB signaling (GO:0038061)2.76014468
56negative regulation of neurotransmitter secretion (GO:0046929)2.75363709
57DNA damage response, signal transduction resulting in transcription (GO:0042772)2.75266855
58histone H3-K36 demethylation (GO:0070544)2.74636296
59negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73018366
60negative regulation of translation, ncRNA-mediated (GO:0040033)2.73018366
61regulation of translation, ncRNA-mediated (GO:0045974)2.73018366
62macrophage activation involved in immune response (GO:0002281)2.70905373
63histone H3-K4 methylation (GO:0051568)2.70374406
64positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.69516881
65mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.69516881
66positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.69093296
67positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.69093296
68positive regulation of mitotic sister chromatid separation (GO:1901970)2.69093296
69regulation of sister chromatid cohesion (GO:0007063)2.67917850
70regulation of mitotic spindle organization (GO:0060236)2.65840962
71positive regulation of interferon-alpha production (GO:0032727)2.65481037
72regulation of B cell differentiation (GO:0045577)2.65147336
73cellular extravasation (GO:0045123)2.63152200
74positive regulation of interferon-beta production (GO:0032728)2.61695209
75mitotic chromosome condensation (GO:0007076)2.60317415
76protein dealkylation (GO:0008214)2.59746473
77protein demethylation (GO:0006482)2.59746473
78protein localization to chromosome, centromeric region (GO:0071459)2.58465706
79germinal center formation (GO:0002467)2.57697195
80metaphase plate congression (GO:0051310)2.57101181
81B cell homeostasis (GO:0001782)2.56277926
82negative regulation of T cell mediated immunity (GO:0002710)2.55550812
83response to lipoprotein particle (GO:0055094)2.55088984
84NLS-bearing protein import into nucleus (GO:0006607)2.54693183
85regulation of interferon-alpha production (GO:0032647)2.53923258
86myeloid leukocyte mediated immunity (GO:0002444)2.53684691
87cellular response to ethanol (GO:0071361)2.53290051
88regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.52916001
89B cell receptor signaling pathway (GO:0050853)2.50719363
90response to UV-C (GO:0010225)2.47253253
91negative regulation of interleukin-12 production (GO:0032695)2.46597113
92histone H2A monoubiquitination (GO:0035518)2.46318266
93B cell mediated immunity (GO:0019724)2.46102368
94positive regulation of B cell differentiation (GO:0045579)2.44672657
95cellular response to nerve growth factor stimulus (GO:1990090)2.43841236
96response to nerve growth factor (GO:1990089)2.43841236
97pre-miRNA processing (GO:0031054)2.43237231
98corticosteroid receptor signaling pathway (GO:0031958)2.42931097
99regulation of histone H3-K27 methylation (GO:0061085)2.42682870
100response to pheromone (GO:0019236)2.40540455
101establishment of chromosome localization (GO:0051303)2.40319678
102interleukin-6-mediated signaling pathway (GO:0070102)2.39837065
103regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.39466408
104retinal cone cell development (GO:0046549)2.39235065
105phosphatidylinositol dephosphorylation (GO:0046856)2.39079485
106meiotic chromosome segregation (GO:0045132)2.38994078
107neutrophil activation (GO:0042119)2.38696983
108N-terminal protein amino acid acetylation (GO:0006474)2.38505858
109natural killer cell mediated cytotoxicity (GO:0042267)2.37870960
110natural killer cell mediated immunity (GO:0002228)2.37870960
111kinetochore organization (GO:0051383)2.35557682
112RNA destabilization (GO:0050779)2.35341206
113protein targeting to vacuole (GO:0006623)2.34138647
114protein targeting to lysosome (GO:0006622)2.34138647
115establishment of protein localization to vacuole (GO:0072666)2.34138647
116positive regulation of granulocyte differentiation (GO:0030854)2.34020386
117histone mRNA catabolic process (GO:0071044)2.33460704
118regulation of integrin activation (GO:0033623)2.33387810
119negative thymic T cell selection (GO:0045060)2.32590648
120spermatid nucleus differentiation (GO:0007289)2.32163966
121histone lysine methylation (GO:0034968)2.31686019
122positive regulation of chromosome segregation (GO:0051984)2.30971078
123histone H3-K9 methylation (GO:0051567)2.30760769
124negative regulation of B cell proliferation (GO:0030889)2.29638146
125regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.29012534
126organelle transport along microtubule (GO:0072384)2.28991918
127piRNA metabolic process (GO:0034587)2.28602948
128regulation of nucleobase-containing compound transport (GO:0032239)2.27969451
129positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.27828390
130phospholipid dephosphorylation (GO:0046839)2.26421333
131regulation of meiosis I (GO:0060631)2.26211226
132protein localization to Golgi apparatus (GO:0034067)2.25682028
133antigen processing and presentation via MHC class Ib (GO:0002475)2.25368688
134Rap protein signal transduction (GO:0032486)2.24462377
135negative regulation of granulocyte differentiation (GO:0030853)2.23912768
136negative T cell selection (GO:0043383)2.23577064
137negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.23173051
138response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.23163313
139response to host (GO:0075136)2.23163313
140response to host defenses (GO:0052200)2.23163313
141regulation of histone H3-K9 methylation (GO:0051570)2.23154329
142intra-Golgi vesicle-mediated transport (GO:0006891)2.23059072
143granulocyte activation (GO:0036230)2.22522016
144neutrophil activation involved in immune response (GO:0002283)2.22484083
145histone H3-K9 modification (GO:0061647)2.21674176
146response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.21045423
147response to host immune response (GO:0052572)2.21045423
148JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.20172182
149positive regulation of gene expression, epigenetic (GO:0045815)2.19817086
150protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.16657633
151female gamete generation (GO:0007292)2.15220182
152DNA methylation involved in gamete generation (GO:0043046)2.14919836
153negative regulation of Rho protein signal transduction (GO:0035024)2.14065133
154regulation of fibroblast apoptotic process (GO:2000269)2.13527426
155reproduction (GO:0000003)2.13126059
156negative regulation of lymphocyte mediated immunity (GO:0002707)2.11575527
157acrosome assembly (GO:0001675)2.11134366
158interkinetic nuclear migration (GO:0022027)2.10900332
159gene silencing by RNA (GO:0031047)2.10286931
160histone H4-K16 acetylation (GO:0043984)2.09172894
161microglial cell activation (GO:0001774)2.08282290

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.25552712
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.98373024
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.46675830
4EZH2_22144423_ChIP-Seq_EOC_Human4.17019392
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.95765737
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.74821601
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.58977908
8* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.55621027
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.04296131
10MYC_22102868_ChIP-Seq_BL_Human2.88325280
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68248133
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.62805543
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.55161640
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.49914354
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.49726288
16GBX2_23144817_ChIP-Seq_PC3_Human2.44175315
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.43626638
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.43121751
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39814230
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.34475305
21TAF15_26573619_Chip-Seq_HEK293_Human2.33160487
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.31946113
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31328135
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.23445417
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.10709979
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.10536027
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.06318912
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.05550891
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05423015
30SALL1_21062744_ChIP-ChIP_HESCs_Human2.04909397
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.98342067
32* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98271928
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.92860383
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.92227477
35SCL_19346495_ChIP-Seq_HPC-7_Human1.91400886
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.90397502
37MYB_26560356_Chip-Seq_TH1_Human1.89813069
38TCF7_22412390_ChIP-Seq_EML_Mouse1.88584609
39MYB_26560356_Chip-Seq_TH2_Human1.86187968
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83577894
41* SPI1_23547873_ChIP-Seq_NB4_Human1.82679221
42VDR_21846776_ChIP-Seq_THP-1_Human1.80607703
43RUNX_20019798_ChIP-Seq_JUKART_Human1.77131669
44MAF_26560356_Chip-Seq_TH1_Human1.75912372
45* NOTCH1_21737748_ChIP-Seq_TLL_Human1.75303267
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72354363
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69750982
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68386908
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67382041
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.60531401
51SMAD4_21799915_ChIP-Seq_A2780_Human1.59950008
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59379020
53IGF1R_20145208_ChIP-Seq_DFB_Human1.59306180
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59007172
55UTX_26944678_Chip-Seq_JUKART_Human1.56905732
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.55703934
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.55462833
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55210629
59VDR_24763502_ChIP-Seq_THP-1_Human1.49339268
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47957130
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46761072
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.46560001
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.46543962
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45832698
65* SPI1_23127762_ChIP-Seq_K562_Human1.45644161
66HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.44861922
67P300_19829295_ChIP-Seq_ESCs_Human1.44741789
68STAT3_23295773_ChIP-Seq_U87_Human1.44316983
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44223835
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39950789
71AHR_22903824_ChIP-Seq_MCF-7_Human1.39009346
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38554595
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.36163331
74CBP_20019798_ChIP-Seq_JUKART_Human1.34918056
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34918056
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.33496065
77CIITA_25753668_ChIP-Seq_RAJI_Human1.31978397
78TCF4_23295773_ChIP-Seq_U87_Human1.31331248
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30753963
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30644915
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30644915
82PU_27001747_Chip-Seq_BMDM_Mouse1.29435789
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29315025
84KDM2B_26808549_Chip-Seq_DND41_Human1.28134479
85* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27323466
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.26391095
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26359447
88CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25891226
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25715012
90TP53_16413492_ChIP-PET_HCT116_Human1.25227332
91GATA3_27048872_Chip-Seq_THYMUS_Human1.24850470
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24379731
93CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22166347
94FLI1_27457419_Chip-Seq_LIVER_Mouse1.21217311
95FUS_26573619_Chip-Seq_HEK293_Human1.20465710
96TCF4_18268006_ChIP-ChIP_LS174T_Human1.17976862
97E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17576850
98* AR_25329375_ChIP-Seq_VCAP_Human1.16616043
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16396550
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.15962505
101GATA2_21666600_ChIP-Seq_HMVEC_Human1.15598162
102EZH2_27294783_Chip-Seq_NPCs_Mouse1.15232963
103PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15049106
104ER_23166858_ChIP-Seq_MCF-7_Human1.14177055
105RUNX2_22187159_ChIP-Seq_PCA_Human1.13838086
106AR_21909140_ChIP-Seq_LNCAP_Human1.13068104
107E2F1_18555785_Chip-Seq_ESCs_Mouse1.13003520
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10719914
109SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10210276
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07464606
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07088898
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07020027
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06061225
114PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05668598
115KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05401767
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05356197
117ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04524444
118CMYC_18555785_Chip-Seq_ESCs_Mouse1.04392185
119FLI1_21867929_ChIP-Seq_TH2_Mouse1.03972576
120SOX2_21211035_ChIP-Seq_LN229_Gbm1.03882024
121SMRT_27268052_Chip-Seq_Bcells_Human1.03861294
122RXR_22108803_ChIP-Seq_LS180_Human1.03442967
123KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.03120864
124KDM2B_26808549_Chip-Seq_REH_Human1.02836680
125TFEB_21752829_ChIP-Seq_HELA_Human1.01498005
126PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01464455
127TP63_23658742_ChIP-Seq_EP156T_Human1.00844689
128VDR_24787735_ChIP-Seq_THP-1_Human0.99966529
129AR_21572438_ChIP-Seq_LNCaP_Human0.99940953
130BRD4_25478319_ChIP-Seq_HGPS_Human0.99562212
131NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98385127
132CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98265047
133FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98043109
134FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97042217
135NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96359327
136KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96114526
137TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95615273
138FOXO3_23340844_ChIP-Seq_DLD1_Human0.95194969
139ELK3_25401928_ChIP-Seq_HUVEC_Human0.94038349
140NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93755192
141ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92581968
142GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92267952
143CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90550475
144GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87279362
145MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.86902388
146NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86671435
147SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86136247
148* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85457039
149* NCOR1_26117541_ChIP-Seq_K562_Human0.84451607
150ELK1_19687146_ChIP-ChIP_HELA_Human0.83997986
151CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82434223
152KDM2B_26808549_Chip-Seq_JURKAT_Human0.82322558
153KDM5A_27292631_Chip-Seq_BREAST_Human0.81695839
154* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81273404
155PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81192704
156MYCN_18555785_ChIP-Seq_MESCs_Mouse0.79947932
157CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79145896
158CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77935753
159VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.77912951
160MAF_26560356_Chip-Seq_TH2_Human0.77241387
161SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.77083839
162SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.77083839
163* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.76952276
164RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.75294779
165RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.74829869
166TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.74238968
167TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.74097279
168PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.73014367

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.26017004
2MP0001835_abnormal_antigen_presentation3.00048616
3MP0005076_abnormal_cell_differentiation2.61922443
4MP0008057_abnormal_DNA_replication2.54551368
5MP0003724_increased_susceptibility_to2.54205769
6MP0002396_abnormal_hematopoietic_system2.34779212
7MP0001800_abnormal_humoral_immune2.24744086
8MP0003436_decreased_susceptibility_to2.19719456
9MP0010352_gastrointestinal_tract_polyps2.19356399
10MP0009278_abnormal_bone_marrow2.15012006
11MP0000685_abnormal_immune_system2.14982169
12MP0002452_abnormal_antigen_presenting2.06389540
13MP0004808_abnormal_hematopoietic_stem2.01556023
14MP0005387_immune_system_phenotype2.01174121
15MP0001790_abnormal_immune_system2.01174121
16MP0003303_peritoneal_inflammation2.00840966
17MP0005000_abnormal_immune_tolerance2.00397196
18MP0003693_abnormal_embryo_hatching1.99500037
19MP0003221_abnormal_cardiomyocyte_apopto1.99114830
20MP0003718_maternal_effect1.98439849
21MP0003077_abnormal_cell_cycle1.97820438
22MP0008007_abnormal_cellular_replicative1.94242323
23MP0005671_abnormal_response_to1.92497112
24MP0001545_abnormal_hematopoietic_system1.89533050
25MP0005397_hematopoietic_system_phenotyp1.89533050
26MP0002398_abnormal_bone_marrow1.80430765
27MP0002723_abnormal_immune_serum1.79908609
28MP0008260_abnormal_autophagy1.79826277
29MP0002419_abnormal_innate_immunity1.78394172
30MP0004270_analgesia1.78089365
31MP0002420_abnormal_adaptive_immunity1.76742388
32MP0001819_abnormal_immune_cell1.75938448
33MP0003656_abnormal_erythrocyte_physiolo1.74354414
34MP0003763_abnormal_thymus_physiology1.70819214
35MP0004484_altered_response_of1.70445817
36MP0002006_tumorigenesis1.69972302
37MP0010094_abnormal_chromosome_stability1.67530054
38MP0003111_abnormal_nucleus_morphology1.67271671
39MP0005409_darkened_coat_color1.65472712
40MP0009785_altered_susceptibility_to1.64189017
41MP0002166_altered_tumor_susceptibility1.63816842
42MP0010307_abnormal_tumor_latency1.62127508
43MP0005025_abnormal_response_to1.60544945
44MP0004947_skin_inflammation1.60160067
45MP0004233_abnormal_muscle_weight1.55239238
46MP0000716_abnormal_immune_system1.54742437
47MP0003300_gastrointestinal_ulcer1.50195819
48MP0003121_genomic_imprinting1.48728085
49MP0003705_abnormal_hypodermis_morpholog1.44779407
50MP0000689_abnormal_spleen_morphology1.44033500
51MP0005174_abnormal_tail_pigmentation1.43798134
52MP0000350_abnormal_cell_proliferation1.42691569
53MP0002405_respiratory_system_inflammati1.42370817
54MP0003183_abnormal_peptide_metabolism1.40359140
55MP0010678_abnormal_skin_adnexa1.37962367
56MP0001984_abnormal_olfaction1.37788546
57MP0002102_abnormal_ear_morphology1.35838667
58MP0003448_altered_tumor_morphology1.35720353
59MP0001853_heart_inflammation1.35379907
60MP0002722_abnormal_immune_system1.34020421
61MP0009333_abnormal_splenocyte_physiolog1.31452967
62MP0002877_abnormal_melanocyte_morpholog1.30005989
63MP0002332_abnormal_exercise_endurance1.29152207
64MP0002429_abnormal_blood_cell1.29037509
65MP0005499_abnormal_olfactory_system1.27332576
66MP0005394_taste/olfaction_phenotype1.27332576
67MP0000703_abnormal_thymus_morphology1.26080482
68MP0001915_intracranial_hemorrhage1.25452213
69MP0010155_abnormal_intestine_physiology1.25348073
70MP0003172_abnormal_lysosome_physiology1.23248318
71MP0004957_abnormal_blastocyst_morpholog1.23093833
72MP0003091_abnormal_cell_migration1.21394171
73MP0003566_abnormal_cell_adhesion1.19028783
74MP0005464_abnormal_platelet_physiology1.18668878
75MP0004510_myositis1.18171100
76MP0005310_abnormal_salivary_gland1.17686845
77MP0000015_abnormal_ear_pigmentation1.17025448
78MP0002928_abnormal_bile_duct1.14302187
79MP0005380_embryogenesis_phenotype1.11844548
80MP0001672_abnormal_embryogenesis/_devel1.11844548
81MP0003984_embryonic_growth_retardation1.11642605
82* MP0001730_embryonic_growth_arrest1.10068093
83MP0002148_abnormal_hypersensitivity_rea1.09989227
84MP0002088_abnormal_embryonic_growth/wei1.09928167
85MP0001929_abnormal_gametogenesis1.09438313
86MP0001501_abnormal_sleep_pattern1.09209160
87MP0004264_abnormal_extraembryonic_tissu1.08892888
88MP0002086_abnormal_extraembryonic_tissu1.07511614
89MP0000371_diluted_coat_color1.06873556
90MP0004811_abnormal_neuron_physiology1.06693553
91MP0001845_abnormal_inflammatory_respons1.04866891
92MP0006082_CNS_inflammation1.04664073
93MP0003690_abnormal_glial_cell1.04226809
94MP0000767_abnormal_smooth_muscle1.04100595
95MP0000490_abnormal_crypts_of1.03579268
96MP0002019_abnormal_tumor_incidence1.03257989
97MP0009384_cardiac_valve_regurgitation1.02945014
98MP0005395_other_phenotype1.02346728
99MP0005410_abnormal_fertilization1.00562477
100MP0008058_abnormal_DNA_repair1.00086915
101MP0000383_abnormal_hair_follicle0.99673692
102MP0010234_abnormal_vibrissa_follicle0.98893222
103MP0000858_altered_metastatic_potential0.98275890
104MP0003828_pulmonary_edema0.97000593
105MP0003453_abnormal_keratinocyte_physiol0.96833772
106MP0008789_abnormal_olfactory_epithelium0.96260065
107MP0000427_abnormal_hair_cycle0.95844586
108MP0003191_abnormal_cellular_cholesterol0.95096321
109MP0003890_abnormal_embryonic-extraembry0.95093332
110MP0005248_abnormal_Harderian_gland0.95038884
111MP0003699_abnormal_female_reproductive0.93345740
112MP0001533_abnormal_skeleton_physiology0.93309175
113MP0000733_abnormal_muscle_development0.93028015
114MP0000465_gastrointestinal_hemorrhage0.92224491
115MP0008961_abnormal_basal_metabolism0.90190902
116MP0005621_abnormal_cell_physiology0.89456949
117MP0003567_abnormal_fetal_cardiomyocyte0.88806977
118MP0005023_abnormal_wound_healing0.87746591
119MP0004197_abnormal_fetal_growth/weight/0.86063881
120MP0001851_eye_inflammation0.85844808
121MP0001697_abnormal_embryo_size0.85235425
122MP0000313_abnormal_cell_death0.84638639
123MP0001986_abnormal_taste_sensitivity0.84156719
124MP0000778_abnormal_nervous_system0.83869184
125MP0003950_abnormal_plasma_membrane0.83856004
126MP0005164_abnormal_response_to0.83549322
127MP0004883_abnormal_blood_vessel0.83465565
128* MP0002085_abnormal_embryonic_tissue0.81997852
129MP0001849_ear_inflammation0.80038286
130MP0003787_abnormal_imprinting0.78684642
131* MP0002084_abnormal_developmental_patter0.78386337
132MP0002998_abnormal_bone_remodeling0.78222302
133MP0001529_abnormal_vocalization0.77882614
134MP0002925_abnormal_cardiovascular_devel0.77673172
135MP0000627_abnormal_mammary_gland0.77408973
136MP0008877_abnormal_DNA_methylation0.77216748
137MP0000920_abnormal_myelination0.76704715
138MP0004924_abnormal_behavior0.75790784
139MP0005386_behavior/neurological_phenoty0.75790784
140MP0002095_abnormal_skin_pigmentation0.75378915
141MP0009115_abnormal_fat_cell0.74117093
142MP0005384_cellular_phenotype0.72521227
143MP0008995_early_reproductive_senescence0.69771152
144MP0003698_abnormal_male_reproductive0.66559111
145MP0002161_abnormal_fertility/fecundity0.65885521
146MP0005647_abnormal_sex_gland0.65604500
147MP0008874_decreased_physiological_sensi0.65018937
148MP0003633_abnormal_nervous_system0.64333482

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)3.84628253
2Abnormality of the fingertips (HP:0001211)3.80999774
3Eczematoid dermatitis (HP:0000976)3.60597080
4Recurrent bacterial skin infections (HP:0005406)3.37975130
5Prostate neoplasm (HP:0100787)3.20358981
6Volvulus (HP:0002580)3.07494034
7Subacute progressive viral hepatitis (HP:0006572)3.03855503
8Amyotrophic lateral sclerosis (HP:0007354)3.03557907
9Thyroid carcinoma (HP:0002890)3.02251959
10Recurrent fungal infections (HP:0002841)2.94298334
11Recurrent viral infections (HP:0004429)2.92863853
12Mediastinal lymphadenopathy (HP:0100721)2.89609919
13Acute myeloid leukemia (HP:0004808)2.87565098
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.85131883
15Autoimmune thrombocytopenia (HP:0001973)2.82375402
16Chromsome breakage (HP:0040012)2.80350542
17Truncal obesity (HP:0001956)2.75839771
18Long eyelashes (HP:0000527)2.71981110
19Menstrual irregularities (HP:0000858)2.70183113
20Optic neuritis (HP:0100653)2.70093495
21Retrobulbar optic neuritis (HP:0100654)2.70093495
22Tubulointerstitial nephritis (HP:0001970)2.64998568
23Excessive salivation (HP:0003781)2.64779623
24Recurrent gram-negative bacterial infections (HP:0005420)2.61469230
25Drooling (HP:0002307)2.60099001
26Loss of speech (HP:0002371)2.55572909
27Spontaneous hematomas (HP:0007420)2.54976307
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.54208669
29Cortical dysplasia (HP:0002539)2.53796440
30Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.53541163
31Orchitis (HP:0100796)2.50314933
32Myositis (HP:0100614)2.48734333
33Apathy (HP:0000741)2.48548510
34Widely spaced teeth (HP:0000687)2.42634594
35Hematochezia (HP:0002573)2.42383164
36Cellulitis (HP:0100658)2.41323131
37Fair hair (HP:0002286)2.39142010
38Thyroiditis (HP:0100646)2.39048772
39Gingivitis (HP:0000230)2.37057007
40Resting tremor (HP:0002322)2.35709311
41Vasculitis (HP:0002633)2.34320226
42Pustule (HP:0200039)2.34239689
43Leukocytosis (HP:0001974)2.34236674
44Albinism (HP:0001022)2.33320275
45Diminished motivation (HP:0000745)2.28824024
46Inappropriate behavior (HP:0000719)2.28276237
47Absent speech (HP:0001344)2.23824872
48Febrile seizures (HP:0002373)2.23198291
49Heterotopia (HP:0002282)2.22348932
50Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.22060853
51Elevated erythrocyte sedimentation rate (HP:0003565)2.21801410
52Abnormality of the columella (HP:0009929)2.20654260
53Tented upper lip vermilion (HP:0010804)2.19068463
54Urethral obstruction (HP:0000796)2.18946112
55Syringomyelia (HP:0003396)2.17066390
56Spinal cord lesions (HP:0100561)2.17066390
57Agnosia (HP:0010524)2.16613879
58Fatigue (HP:0012378)2.16231249
59Ectopic kidney (HP:0000086)2.15584431
60Medulloblastoma (HP:0002885)2.15221651
61Recurrent skin infections (HP:0001581)2.14824622
62IgM deficiency (HP:0002850)2.13817391
63Tubulointerstitial abnormality (HP:0001969)2.12832691
64Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.10343648
65Meningitis (HP:0001287)2.08379322
66Pulmonary infiltrates (HP:0002113)2.07834542
67Gonadotropin excess (HP:0000837)2.07437498
68Abnormality of salivation (HP:0100755)2.06376179
69Abnormality of macrophages (HP:0004311)2.05777930
70Arterial thrombosis (HP:0004420)2.05567120
71Periodontitis (HP:0000704)2.03423900
72Severe combined immunodeficiency (HP:0004430)2.02676855
73Generalized hypopigmentation of hair (HP:0011358)2.02400206
74Lymphopenia (HP:0001888)2.00109554
75Viral hepatitis (HP:0006562)1.99893713
76Progressive inability to walk (HP:0002505)1.98337026
77Supranuclear gaze palsy (HP:0000605)1.97909655
78Chronic mucocutaneous candidiasis (HP:0002728)1.97687277
79Recurrent cutaneous fungal infections (HP:0011370)1.97687277
80Postural instability (HP:0002172)1.96036708
81Narrow palate (HP:0000189)1.96035784
82Abnormality of the prostate (HP:0008775)1.95897477
83Spondylolisthesis (HP:0003302)1.95820415
84Prominent nose (HP:0000448)1.95471785
85Papillary thyroid carcinoma (HP:0002895)1.95216280
86Combined immunodeficiency (HP:0005387)1.94847608
87Hip dysplasia (HP:0001385)1.94257600
88Transitional cell carcinoma of the bladder (HP:0006740)1.94062902
89Abnormality of cells of the lymphoid lineage (HP:0012140)1.92000984
90Abnormality of the corticospinal tract (HP:0002492)1.90877945
91T lymphocytopenia (HP:0005403)1.90627816
92Hyperventilation (HP:0002883)1.90411039
93Osteomalacia (HP:0002749)1.88791964
94Malignant gastrointestinal tract tumors (HP:0006749)1.88604055
95Gastrointestinal carcinoma (HP:0002672)1.88604055
96Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.88344187
97Absent frontal sinuses (HP:0002688)1.87938324
98Anhidrosis (HP:0000970)1.87822412
99Acute lymphatic leukemia (HP:0006721)1.87731415
100Oligodactyly (HP:0012165)1.87273851
101Abnormality of T cell number (HP:0011839)1.86743774
102Uterine leiomyosarcoma (HP:0002891)1.86560443
103Leiomyosarcoma (HP:0100243)1.86560443
104Lip pit (HP:0100267)1.86469898
105Stomatitis (HP:0010280)1.85651719
106Lymphoma (HP:0002665)1.85152333
107Curly hair (HP:0002212)1.85063569
108Obstructive lung disease (HP:0006536)1.85021519
109Chronic obstructive pulmonary disease (HP:0006510)1.85021519
110Gaze-evoked nystagmus (HP:0000640)1.84167322
111Facial hemangioma (HP:0000329)1.83859008
112Osteomyelitis (HP:0002754)1.83781994
113Recurrent bronchitis (HP:0002837)1.83430461
114Birth length less than 3rd percentile (HP:0003561)1.83343892
115Insidious onset (HP:0003587)1.82744420
116Termporal pattern (HP:0011008)1.82744420
117Keratoconjunctivitis (HP:0001096)1.82715913
118Spastic gait (HP:0002064)1.82234322
119Atonic seizures (HP:0010819)1.81602333
120Abnormality of the hip-girdle musculature (HP:0001445)1.81405090
121Abnormality of the musculature of the pelvis (HP:0001469)1.81405090
122Chronic hepatic failure (HP:0100626)1.80029505
123Gastrointestinal stroma tumor (HP:0100723)1.78866814
124Eosinophilia (HP:0001880)1.78805571
125Aqueductal stenosis (HP:0002410)1.78796278
126Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.77314407
127Degeneration of the lateral corticospinal tracts (HP:0002314)1.77314407
128Neuronal loss in central nervous system (HP:0002529)1.77009019
129Emphysema (HP:0002097)1.75115611
130Myelodysplasia (HP:0002863)1.74795941
131Myocardial infarction (HP:0001658)1.74487827
132Abnormality of eosinophils (HP:0001879)1.74446591
133Hypoplastic iliac wings (HP:0002866)1.74420380
134Agammaglobulinemia (HP:0004432)1.73719275
135Rhabdomyosarcoma (HP:0002859)1.73284117
136Premature loss of primary teeth (HP:0006323)1.73223196
137Peripheral hypomyelination (HP:0007182)1.72856635
138Trigonocephaly (HP:0000243)1.72834171
139Abnormal delayed hypersensitivity skin test (HP:0002963)1.72486598
140Abnormal hair whorl (HP:0010721)1.72097189
141Oligodactyly (hands) (HP:0001180)1.71252592
142Cutis marmorata (HP:0000965)1.70423600
143Bladder carcinoma (HP:0002862)1.70135788
144Bladder neoplasm (HP:0009725)1.70135788
145Cone-rod dystrophy (HP:0000548)1.69802244
146Leukopenia (HP:0001882)1.69435323
147Patellar aplasia (HP:0006443)1.69206456
148Progressive cerebellar ataxia (HP:0002073)1.68960153
149Cystic hygroma (HP:0000476)1.68725663
150Action tremor (HP:0002345)1.68077964
151Atrophy/Degeneration involving motor neurons (HP:0007373)1.67159047
152Short 4th metacarpal (HP:0010044)1.66949073
153Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.66949073
154Increased CSF protein (HP:0002922)1.66878302
155Abnormality of the nasal septum (HP:0000419)1.66838139
156Large earlobe (HP:0009748)1.66726931
157Abnormality of the intervertebral disk (HP:0005108)1.66424169
158Amaurosis fugax (HP:0100576)1.64809799
159Sparse lateral eyebrow (HP:0005338)1.64203271
160Chronic otitis media (HP:0000389)1.63634768
161Urinary urgency (HP:0000012)1.63294443
162Abnormality of chromosome stability (HP:0003220)1.63253504
163Deep philtrum (HP:0002002)1.61888695
164Panhypogammaglobulinemia (HP:0003139)1.61403435
165Lower limb muscle weakness (HP:0007340)1.61342259
166Deviation of the thumb (HP:0009603)1.61252718
167Keratoconjunctivitis sicca (HP:0001097)1.60985102
168Upper limb muscle weakness (HP:0003484)1.60967693
169Slow saccadic eye movements (HP:0000514)1.60892805
170Anal stenosis (HP:0002025)1.60830828
171Disinhibition (HP:0000734)1.60373296

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.32841201
2MAP3K103.24748735
3MAP4K12.90948368
4LATS12.73959425
5STK102.20409868
6KSR22.19119929
7BRD42.17247278
8CDC72.10371340
9IRAK42.04524895
10RIPK41.96028009
11MAP3K141.95112742
12CASK1.93632212
13JAK31.92764353
14TRIM281.80232566
15BCR1.79248237
16MARK31.78456608
17CAMK1D1.69320527
18STK31.67563462
19MAP3K91.66480801
20SGK21.64771483
21IRAK31.62298714
22TYK21.60780436
23CHUK1.60486974
24IKBKB1.57667008
25ERBB31.55121178
26TXK1.54693409
27BRSK21.49597352
28NEK21.48776112
29MAP3K41.46502306
30WNK11.45017230
31MELK1.43115194
32KIT1.37776562
33TBK11.37588356
34FGFR31.35666872
35SGK31.32878287
36CSF1R1.32172328
37AKT31.30119621
38CDK61.27185740
39JAK11.27005276
40TNIK1.25354625
41IKBKE1.25306391
42PNCK1.22522623
43TAOK31.22385093
44EPHA31.21580501
45PIM11.20143299
46SIK31.14168521
47CDK41.12976058
48CAMK1G1.12606190
49MAP3K21.11191988
50STK241.10174333
51IRAK21.09586531
52NEK61.09117117
53STK41.08488762
54HCK1.08051747
55RPS6KA41.07330953
56FGFR41.06716931
57MAPK131.05711394
58CAMKK21.03667423
59MAP3K131.00544857
60MARK20.98601673
61STK380.98571094
62TGFBR20.97684814
63CDK90.97101819
64EIF2AK30.94983017
65PTK2B0.93839482
66ERN10.93567865
67BLK0.93135461
68TEC0.92990296
69SGK4940.92614919
70SGK2230.92614919
71ARAF0.91620766
72TAOK10.91337503
73LATS20.90792932
74CHEK20.90208877
75BTK0.90105581
76PRPF4B0.89484070
77NUAK10.87032048
78MAP3K60.86594552
79CLK10.86346165
80CSK0.86123904
81MARK10.85571268
82CSNK1A1L0.84913392
83NTRK30.84391263
84ATR0.82925746
85PDGFRB0.82438794
86GRK60.82032271
87CHEK10.82029112
88SRPK10.81849888
89NLK0.81553888
90CAMK40.81362069
91CDK70.80854930
92ZAP700.80060046
93BMPR20.79683982
94ITK0.78102390
95MAP2K30.77764575
96MAP3K30.76194963
97NTRK20.75582184
98ABL10.75450401
99MATK0.74676641
100PAK30.73632443
101SYK0.73492805
102MOS0.73011679
103MTOR0.72603654
104LCK0.71845044
105ACVR1B0.71465554
106NEK90.70750628
107ERBB40.70078452
108SIK20.70018272
109PLK40.69819332
110LYN0.67216522
111MAP3K50.66551166
112DYRK1A0.66252733
113KSR10.66005132
114ATM0.64436116
115MAPK70.63811002
116EEF2K0.63437956
117MAP4K20.63370979
118DYRK30.63357149
119MAP2K40.63110609
120RET0.60989119
121WEE10.59882628
122DYRK1B0.59613425
123CSNK1G10.59503584
124JAK20.58544139
125DMPK0.57283067
126PASK0.56222031
127FES0.54200421
128BMX0.53778717
129CDK20.52208484
130RAF10.52172137
131AURKB0.52040264
132CDK50.51860857
133MAP3K80.51551086
134TTK0.51460227
135PLK10.51374128
136EPHB10.50986379
137FGFR20.50052632
138MAP3K70.49395376
139CSNK1G30.49138240
140YES10.47562072
141PRKCZ0.47476400
142CSNK1G20.46730042
143MST40.46707844
144PLK20.46578704
145PRKG10.45783489
146PAK40.45583495
147FGR0.44878167
148EGFR0.43828922
149IRAK10.41141256
150LRRK20.40805111
151MAPK10.40523380
152HIPK20.39280113
153MAPK100.38558583
154MAPK140.38204739
155AKT10.38063499
156PTK60.36957376

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.32002662
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.22676856
3B cell receptor signaling pathway_Homo sapiens_hsa046622.06921630
4Circadian rhythm_Homo sapiens_hsa047101.90914570
5Osteoclast differentiation_Homo sapiens_hsa043801.85009440
6Primary immunodeficiency_Homo sapiens_hsa053401.76653276
7Measles_Homo sapiens_hsa051621.71083837
8Herpes simplex infection_Homo sapiens_hsa051681.65670338
9NOD-like receptor signaling pathway_Homo sapiens_hsa046211.65496261
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60152852
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59027103
12Cell cycle_Homo sapiens_hsa041101.58485710
13Phosphatidylinositol signaling system_Homo sapiens_hsa040701.58260996
14p53 signaling pathway_Homo sapiens_hsa041151.49753282
15Inositol phosphate metabolism_Homo sapiens_hsa005621.48248428
16TNF signaling pathway_Homo sapiens_hsa046681.47492921
17MicroRNAs in cancer_Homo sapiens_hsa052061.47163961
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.46843143
19T cell receptor signaling pathway_Homo sapiens_hsa046601.45477510
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44168064
21Toxoplasmosis_Homo sapiens_hsa051451.40697745
22Chronic myeloid leukemia_Homo sapiens_hsa052201.40690151
23Hematopoietic cell lineage_Homo sapiens_hsa046401.40557693
24Influenza A_Homo sapiens_hsa051641.40295924
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37707347
26Hepatitis B_Homo sapiens_hsa051611.35098532
27Shigellosis_Homo sapiens_hsa051311.34568252
28Pancreatic cancer_Homo sapiens_hsa052121.34223780
29Legionellosis_Homo sapiens_hsa051341.34130157
30Tuberculosis_Homo sapiens_hsa051521.33632775
31Small cell lung cancer_Homo sapiens_hsa052221.31321541
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31298218
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.30012003
34Staphylococcus aureus infection_Homo sapiens_hsa051501.26434708
35Apoptosis_Homo sapiens_hsa042101.24209066
36Antigen processing and presentation_Homo sapiens_hsa046121.23310796
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.23229041
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22713764
39Adherens junction_Homo sapiens_hsa045201.22494011
40ErbB signaling pathway_Homo sapiens_hsa040121.21885458
41Notch signaling pathway_Homo sapiens_hsa043301.19343705
42Acute myeloid leukemia_Homo sapiens_hsa052211.18734270
43Epstein-Barr virus infection_Homo sapiens_hsa051691.18467286
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16065098
45Long-term potentiation_Homo sapiens_hsa047201.15559499
46Colorectal cancer_Homo sapiens_hsa052101.14724056
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13027083
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12980401
49Pertussis_Homo sapiens_hsa051331.09849051
50Viral carcinogenesis_Homo sapiens_hsa052031.09714741
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.08844457
52Malaria_Homo sapiens_hsa051441.08230901
53Chemokine signaling pathway_Homo sapiens_hsa040621.07150545
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05618614
55Non-homologous end-joining_Homo sapiens_hsa034501.05590060
56HTLV-I infection_Homo sapiens_hsa051661.04823594
57Lysine degradation_Homo sapiens_hsa003101.04731225
58Viral myocarditis_Homo sapiens_hsa054161.03120433
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02567990
60Type II diabetes mellitus_Homo sapiens_hsa049301.02232862
61mTOR signaling pathway_Homo sapiens_hsa041501.00202606
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99508440
63Gap junction_Homo sapiens_hsa045400.99266886
64Fanconi anemia pathway_Homo sapiens_hsa034600.98556460
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95989996
66Allograft rejection_Homo sapiens_hsa053300.95598332
67Oocyte meiosis_Homo sapiens_hsa041140.95433695
68RNA transport_Homo sapiens_hsa030130.95278112
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94687222
70Long-term depression_Homo sapiens_hsa047300.94423066
71mRNA surveillance pathway_Homo sapiens_hsa030150.93627744
72RNA degradation_Homo sapiens_hsa030180.92885701
73Estrogen signaling pathway_Homo sapiens_hsa049150.92882757
74Phagosome_Homo sapiens_hsa041450.92688306
75Prolactin signaling pathway_Homo sapiens_hsa049170.92220887
76Glioma_Homo sapiens_hsa052140.90906793
77Graft-versus-host disease_Homo sapiens_hsa053320.90097854
78Dorso-ventral axis formation_Homo sapiens_hsa043200.88880073
79GABAergic synapse_Homo sapiens_hsa047270.88451278
80TGF-beta signaling pathway_Homo sapiens_hsa043500.88288623
81FoxO signaling pathway_Homo sapiens_hsa040680.87971155
82Renal cell carcinoma_Homo sapiens_hsa052110.87932280
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87021948
84Proteoglycans in cancer_Homo sapiens_hsa052050.86854599
85Homologous recombination_Homo sapiens_hsa034400.85468752
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84853970
87Salmonella infection_Homo sapiens_hsa051320.84499709
88Prostate cancer_Homo sapiens_hsa052150.83986733
89Endocytosis_Homo sapiens_hsa041440.82982082
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.82863568
91Non-small cell lung cancer_Homo sapiens_hsa052230.82457665
92Platelet activation_Homo sapiens_hsa046110.79597755
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77215550
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76483399
95Nicotine addiction_Homo sapiens_hsa050330.76199999
96Endometrial cancer_Homo sapiens_hsa052130.75812240
97Rap1 signaling pathway_Homo sapiens_hsa040150.75693119
98GnRH signaling pathway_Homo sapiens_hsa049120.75644212
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.74368273
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74095369
101Basal transcription factors_Homo sapiens_hsa030220.73564677
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73341770
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72812698
104Nitrogen metabolism_Homo sapiens_hsa009100.72254729
105Ras signaling pathway_Homo sapiens_hsa040140.71895801
106Pathways in cancer_Homo sapiens_hsa052000.71503795
107Hepatitis C_Homo sapiens_hsa051600.70028008
108Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69440045
109Spliceosome_Homo sapiens_hsa030400.69137684
110Asthma_Homo sapiens_hsa053100.68877881
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68270622
112Axon guidance_Homo sapiens_hsa043600.68219753
113Base excision repair_Homo sapiens_hsa034100.67990532
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.67197866
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66592484
116Morphine addiction_Homo sapiens_hsa050320.66343373
117Choline metabolism in cancer_Homo sapiens_hsa052310.65843660
118Insulin signaling pathway_Homo sapiens_hsa049100.65817793
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63481556
120Ovarian steroidogenesis_Homo sapiens_hsa049130.63317753
121Dopaminergic synapse_Homo sapiens_hsa047280.62707358
122Taste transduction_Homo sapiens_hsa047420.61819122
123Thyroid cancer_Homo sapiens_hsa052160.61373100
124cAMP signaling pathway_Homo sapiens_hsa040240.59382252
125Regulation of autophagy_Homo sapiens_hsa041400.57881900
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56516332
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56464287
128HIF-1 signaling pathway_Homo sapiens_hsa040660.56412573
129Olfactory transduction_Homo sapiens_hsa047400.55217989
130MAPK signaling pathway_Homo sapiens_hsa040100.54736438
131African trypanosomiasis_Homo sapiens_hsa051430.54529552
132VEGF signaling pathway_Homo sapiens_hsa043700.53728814
133Amoebiasis_Homo sapiens_hsa051460.51922788
134Lysosome_Homo sapiens_hsa041420.49690299
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.49324467
136Mismatch repair_Homo sapiens_hsa034300.48952848
137RNA polymerase_Homo sapiens_hsa030200.48682970

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