RNF112

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the RING finger protein family of transcription factors. The protein is primarily expressed in brain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.50984203
2synaptic vesicle maturation (GO:0016188)6.28609800
3locomotory exploration behavior (GO:0035641)6.16993099
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.81119210
5ionotropic glutamate receptor signaling pathway (GO:0035235)5.78182769
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.75913621
7glutamate secretion (GO:0014047)5.57702999
8neuronal action potential propagation (GO:0019227)5.42938755
9vocalization behavior (GO:0071625)5.27784357
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.18885317
11synaptic vesicle exocytosis (GO:0016079)5.12862948
12synaptic transmission, glutamatergic (GO:0035249)5.12828367
13synaptic vesicle docking involved in exocytosis (GO:0016081)5.08649755
14glutamate receptor signaling pathway (GO:0007215)4.98365702
15postsynaptic membrane organization (GO:0001941)4.97405646
16regulation of synaptic vesicle exocytosis (GO:2000300)4.90732120
17regulation of glutamate receptor signaling pathway (GO:1900449)4.83748973
18regulation of neuronal synaptic plasticity (GO:0048168)4.70088612
19neurotransmitter secretion (GO:0007269)4.69917988
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.60545480
21neuron-neuron synaptic transmission (GO:0007270)4.54559507
22gamma-aminobutyric acid transport (GO:0015812)4.50895659
23exploration behavior (GO:0035640)4.49085001
24regulation of synaptic vesicle transport (GO:1902803)4.43034961
25cellular potassium ion homeostasis (GO:0030007)4.41146210
26regulation of synapse structural plasticity (GO:0051823)4.37445145
27long-term memory (GO:0007616)4.30837811
28protein localization to synapse (GO:0035418)4.30788866
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.20334926
30regulation of excitatory postsynaptic membrane potential (GO:0060079)4.19216278
31cerebellar Purkinje cell differentiation (GO:0021702)4.17785924
32sodium ion export (GO:0071436)4.16144403
33amino acid import (GO:0043090)4.13720637
34central nervous system myelination (GO:0022010)4.13081075
35axon ensheathment in central nervous system (GO:0032291)4.13081075
36neurotransmitter-gated ion channel clustering (GO:0072578)4.10709066
37potassium ion homeostasis (GO:0055075)4.05850317
38response to pheromone (GO:0019236)4.05611887
39positive regulation of synapse maturation (GO:0090129)3.97882082
40cerebellar granule cell differentiation (GO:0021707)3.97437560
41neuromuscular process controlling balance (GO:0050885)3.90144742
42regulation of postsynaptic membrane potential (GO:0060078)3.89609344
43dendritic spine morphogenesis (GO:0060997)3.89072059
44positive regulation of membrane potential (GO:0045838)3.87297450
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.84519708
46presynaptic membrane assembly (GO:0097105)3.79394319
47presynaptic membrane organization (GO:0097090)3.79107189
48layer formation in cerebral cortex (GO:0021819)3.78251190
49G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.76997879
50neurotransmitter transport (GO:0006836)3.75744289
51transmission of nerve impulse (GO:0019226)3.75292533
52regulation of synaptic plasticity (GO:0048167)3.72082223
53membrane depolarization during action potential (GO:0086010)3.71801507
54gamma-aminobutyric acid signaling pathway (GO:0007214)3.71513437
55regulation of dendritic spine morphogenesis (GO:0061001)3.70401355
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.69792921
57neuromuscular process controlling posture (GO:0050884)3.67374398
58neuron cell-cell adhesion (GO:0007158)3.65101865
59negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.64531196
60proline transport (GO:0015824)3.56834507
61regulation of neurotransmitter levels (GO:0001505)3.56147713
62regulation of synaptic transmission, glutamatergic (GO:0051966)3.55116494
63membrane depolarization (GO:0051899)3.52673977
64regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.49971854
65cell communication by electrical coupling (GO:0010644)3.48684697
66regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.48599082
67synaptic vesicle endocytosis (GO:0048488)3.47274901
68regulation of neurotransmitter secretion (GO:0046928)3.47067743
69neuron recognition (GO:0008038)3.40811691
70positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.39092927
71long-term synaptic potentiation (GO:0060291)3.38405233
72glycine transport (GO:0015816)3.37404431
73negative regulation of synaptic transmission, GABAergic (GO:0032229)3.36817044
74activation of protein kinase A activity (GO:0034199)3.36479465
75neuronal ion channel clustering (GO:0045161)3.35918241
76regulation of vesicle fusion (GO:0031338)3.30970220
77behavioral defense response (GO:0002209)3.30689798
78behavioral fear response (GO:0001662)3.30689798
79negative regulation of dendrite morphogenesis (GO:0050774)3.28720266
80positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.28535057
81adult walking behavior (GO:0007628)3.28145765
82vesicle docking involved in exocytosis (GO:0006904)3.27978314
83acidic amino acid transport (GO:0015800)3.27856766
84prepulse inhibition (GO:0060134)3.27837110
85regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26540243
86positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.25288607
87chemosensory behavior (GO:0007635)3.22863293
88auditory behavior (GO:0031223)3.22614518
89regulation of neurotransmitter transport (GO:0051588)3.20588101
90negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.19598333
91positive regulation of dendritic spine development (GO:0060999)3.19380679
92potassium ion import (GO:0010107)3.16728605
93positive regulation of dendritic spine morphogenesis (GO:0061003)3.16530721
94positive regulation of synaptic transmission, GABAergic (GO:0032230)3.16506444
95membrane hyperpolarization (GO:0060081)3.15729765
96dendrite morphogenesis (GO:0048813)3.15712566
97positive regulation of neurotransmitter secretion (GO:0001956)3.15638624
98axonal fasciculation (GO:0007413)3.14806650
99fear response (GO:0042596)3.14404554
100neuromuscular process (GO:0050905)3.14341463
101neurotransmitter uptake (GO:0001504)3.14191419
102cellular sodium ion homeostasis (GO:0006883)3.13464611
103cell differentiation in hindbrain (GO:0021533)3.12381959
104dendritic spine organization (GO:0097061)3.11865096
105cell migration in hindbrain (GO:0021535)3.10107836
106regulation of synapse maturation (GO:0090128)3.09801587
107L-amino acid import (GO:0043092)3.09204336
108suckling behavior (GO:0001967)3.08197146
109regulation of synaptic transmission (GO:0050804)3.07263131
110synaptic transmission (GO:0007268)3.06420002
111regulation of voltage-gated calcium channel activity (GO:1901385)3.05494830
112regulation of dendritic spine development (GO:0060998)3.04478846
113positive regulation of neurotransmitter transport (GO:0051590)3.04290448
114regulation of ARF protein signal transduction (GO:0032012)3.03374622
115cerebellar Purkinje cell layer development (GO:0021680)3.03148329
116vesicle docking (GO:0048278)3.02407039
117G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.02074982
118response to auditory stimulus (GO:0010996)3.01208455
119positive regulation of dendrite development (GO:1900006)2.98857768
120cell communication involved in cardiac conduction (GO:0086065)2.98772089
121phosphorelay signal transduction system (GO:0000160)2.96756798
122establishment of mitochondrion localization (GO:0051654)2.94837512

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.16402435
2GBX2_23144817_ChIP-Seq_PC3_Human3.17339192
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08641104
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08575142
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93198612
6DROSHA_22980978_ChIP-Seq_HELA_Human2.89840759
7* RARB_27405468_Chip-Seq_BRAIN_Mouse2.89195007
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79512881
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79512881
10REST_21632747_ChIP-Seq_MESCs_Mouse2.78793233
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64140023
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.63237462
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.59339179
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55762572
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51751588
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.49985247
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42689269
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.36699232
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.35145271
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.33109662
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.30252225
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.24315869
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24261736
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.20734774
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.15816445
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06503582
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01572248
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87549758
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.84813465
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69402529
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.66967421
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65024032
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.51776849
34AR_21572438_ChIP-Seq_LNCaP_Human1.47567595
35ZNF274_21170338_ChIP-Seq_K562_Hela1.43559534
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42546811
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37990591
38* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35516956
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32717519
40TAF15_26573619_Chip-Seq_HEK293_Human1.32580760
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.30462870
42KDM2B_26808549_Chip-Seq_K562_Human1.26924017
43SOX2_21211035_ChIP-Seq_LN229_Gbm1.24764662
44AR_19668381_ChIP-Seq_PC3_Human1.22011875
45GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21859493
46WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19759015
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19596378
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.17876437
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17693540
50EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17158085
51* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16999705
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16614924
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.15753272
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15656347
55STAT3_23295773_ChIP-Seq_U87_Human1.15548424
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14014552
57OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13381938
58AR_25329375_ChIP-Seq_VCAP_Human1.13229635
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13094905
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11197623
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.10317509
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09282118
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08633995
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.08247054
65RNF2_27304074_Chip-Seq_NSC_Mouse1.05848468
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05504364
67P300_19829295_ChIP-Seq_ESCs_Human1.05396142
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05268776
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04632326
70ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04301368
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03707520
72TCF4_23295773_ChIP-Seq_U87_Human1.00838315
73RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00047687
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98485059
75PIAS1_25552417_ChIP-Seq_VCAP_Human0.97462042
76YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96928311
77ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96897897
78MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96476475
79CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96131626
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95597301
81TET1_21490601_ChIP-Seq_MESCs_Mouse0.95251407
82SMAD3_21741376_ChIP-Seq_ESCs_Human0.95072493
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94779366
84KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94584975
85CBX2_27304074_Chip-Seq_ESCs_Mouse0.93663306
86BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91923638
87ARNT_22903824_ChIP-Seq_MCF-7_Human0.91674761
88TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91091577
89CTCF_27219007_Chip-Seq_Bcells_Human0.90471729
90DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89723372
91SMAD3_21741376_ChIP-Seq_HESCs_Human0.88419523
92TP53_20018659_ChIP-ChIP_R1E_Mouse0.88011355
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87890010
94LXR_22292898_ChIP-Seq_THP-1_Human0.87751754
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87688406
96NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87330337
97AHR_22903824_ChIP-Seq_MCF-7_Human0.87284577
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.86991021
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86921864
100PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86669375
101* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86503589
102CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85574355
103* OCT4_19829295_ChIP-Seq_ESCs_Human0.85322652
104TP53_16413492_ChIP-PET_HCT116_Human0.84460816
105RXR_22108803_ChIP-Seq_LS180_Human0.84354561
106PRDM14_20953172_ChIP-Seq_ESCs_Human0.84305345
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.84135336
108* DPY_21335234_ChIP-Seq_ESCs_Mouse0.83766090
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83394974
110RUNX2_22187159_ChIP-Seq_PCA_Human0.83212193
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83172278
112SMC4_20622854_ChIP-Seq_HELA_Human0.83142919
113ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82907813
114KLF4_19829295_ChIP-Seq_ESCs_Human0.82689797
115TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82608155
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82380449
117GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81831683
118ESR2_21235772_ChIP-Seq_MCF-7_Human0.81103959
119SMAD4_21741376_ChIP-Seq_EPCs_Human0.80576192
120TRIM28_21343339_ChIP-Seq_HEK293_Human0.79228032
121TP53_23651856_ChIP-Seq_MEFs_Mouse0.78522542
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77824033
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.77663578
124SOX9_26525672_Chip-Seq_HEART_Mouse0.75382359
125LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74723434
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74400467

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.49455700
2MP0003880_abnormal_central_pattern4.63582115
3MP0003635_abnormal_synaptic_transmissio4.31901837
4MP0009745_abnormal_behavioral_response3.53328975
5MP0009046_muscle_twitch3.52447751
6MP0004270_analgesia3.50924205
7MP0002063_abnormal_learning/memory/cond3.38102832
8MP0002064_seizures3.32193317
9MP0001968_abnormal_touch/_nociception3.32167588
10MP0002822_catalepsy3.04553757
11MP0002272_abnormal_nervous_system2.91933284
12MP0002572_abnormal_emotion/affect_behav2.89634544
13MP0002736_abnormal_nociception_after2.83474086
14MP0002735_abnormal_chemical_nociception2.72880462
15MP0005423_abnormal_somatic_nervous2.61748766
16MP0001501_abnormal_sleep_pattern2.61107558
17MP0002734_abnormal_mechanical_nocicepti2.56862931
18MP0001486_abnormal_startle_reflex2.48543621
19MP0008569_lethality_at_weaning2.33080193
20MP0001440_abnormal_grooming_behavior2.30610938
21MP0002067_abnormal_sensory_capabilities2.13941885
22MP0001970_abnormal_pain_threshold1.97516533
23MP0002733_abnormal_thermal_nociception1.95226717
24MP0003329_amyloid_beta_deposits1.90635120
25MP0002184_abnormal_innervation1.85545151
26MP0004811_abnormal_neuron_physiology1.72132670
27MP0002557_abnormal_social/conspecific_i1.71249629
28MP0005386_behavior/neurological_phenoty1.70953708
29MP0004924_abnormal_behavior1.70953708
30MP0000955_abnormal_spinal_cord1.70378625
31MP0004885_abnormal_endolymph1.69097710
32MP0004858_abnormal_nervous_system1.63007521
33MP0002909_abnormal_adrenal_gland1.59122893
34MP0003879_abnormal_hair_cell1.56810957
35MP0009780_abnormal_chondrocyte_physiolo1.54323049
36MP0004145_abnormal_muscle_electrophysio1.47792510
37MP0000778_abnormal_nervous_system1.47453578
38MP0002066_abnormal_motor_capabilities/c1.46619549
39MP0003633_abnormal_nervous_system1.38991907
40MP0002882_abnormal_neuron_morphology1.38323632
41MP0005646_abnormal_pituitary_gland1.31823616
42MP0001984_abnormal_olfaction1.29512523
43MP0004142_abnormal_muscle_tone1.26100394
44MP0003123_paternal_imprinting1.21614422
45MP0003631_nervous_system_phenotype1.20310249
46MP0003787_abnormal_imprinting1.15144927
47MP0006276_abnormal_autonomic_nervous1.13464388
48MP0001502_abnormal_circadian_rhythm1.12461544
49MP0008872_abnormal_physiological_respon1.09910101
50MP0000013_abnormal_adipose_tissue1.05948677
51MP0002152_abnormal_brain_morphology1.05103253
52MP0003075_altered_response_to1.01437576
53MP0005645_abnormal_hypothalamus_physiol1.01050570
54MP0008874_decreased_physiological_sensi0.99634246
55MP0003632_abnormal_nervous_system0.99577796
56MP0008877_abnormal_DNA_methylation0.98729586
57MP0003690_abnormal_glial_cell0.98173701
58MP0004742_abnormal_vestibular_system0.97464175
59MP0000920_abnormal_myelination0.95652659
60MP0002229_neurodegeneration0.94854065
61MP0002069_abnormal_eating/drinking_beha0.93463173
62MP0000751_myopathy0.91816018
63MP0001905_abnormal_dopamine_level0.91538427
64MP0001348_abnormal_lacrimal_gland0.91509416
65MP0004510_myositis0.90874930
66MP0001986_abnormal_taste_sensitivity0.87678610
67MP0001177_atelectasis0.87288286
68MP0000604_amyloidosis0.86651303
69MP0003283_abnormal_digestive_organ0.85097077
70MP0004085_abnormal_heartbeat0.82746507
71MP0003634_abnormal_glial_cell0.82347651
72MP0001188_hyperpigmentation0.81946514
73MP0008961_abnormal_basal_metabolism0.79956657
74MP0001529_abnormal_vocalization0.78963599
75MP0002638_abnormal_pupillary_reflex0.75140569
76MP0005535_abnormal_body_temperature0.74620755
77MP0003122_maternal_imprinting0.74367408
78MP0001963_abnormal_hearing_physiology0.73994560
79MP0004215_abnormal_myocardial_fiber0.73818610
80MP0001485_abnormal_pinna_reflex0.73695066
81MP0000569_abnormal_digit_pigmentation0.72943138
82MP0004130_abnormal_muscle_cell0.71205162
83MP0005409_darkened_coat_color0.68771867
84MP0005551_abnormal_eye_electrophysiolog0.68394160
85MP0005167_abnormal_blood-brain_barrier0.67497093
86MP0002752_abnormal_somatic_nervous0.66474683
87MP0000747_muscle_weakness0.65551984
88MP0003137_abnormal_impulse_conducting0.63403040
89MP0004043_abnormal_pH_regulation0.62802193
90MP0004484_altered_response_of0.62547233
91MP0000026_abnormal_inner_ear0.62510701
92MP0001299_abnormal_eye_distance/0.60595000
93MP0003121_genomic_imprinting0.59573308
94MP0000631_abnormal_neuroendocrine_gland0.58241783
95MP0005623_abnormal_meninges_morphology0.58224308
96MP0010769_abnormal_survival0.56805868
97MP0001346_abnormal_lacrimal_gland0.56711951
98MP0004147_increased_porphyrin_level0.56007018
99MP0000579_abnormal_nail_morphology0.55772367
100MP0002089_abnormal_postnatal_growth/wei0.55577757
101MP0005499_abnormal_olfactory_system0.53532607
102MP0005394_taste/olfaction_phenotype0.53532607
103MP0010768_mortality/aging0.53391736
104MP0010770_preweaning_lethality0.53382489
105MP0002082_postnatal_lethality0.53382489
106MP0010386_abnormal_urinary_bladder0.52856126
107MP0003956_abnormal_body_size0.50035182
108MP0002234_abnormal_pharynx_morphology0.49095009
109MP0002090_abnormal_vision0.48755144
110MP0003861_abnormal_nervous_system0.48472130
111MP0001943_abnormal_respiration0.48094323
112MP0002249_abnormal_larynx_morphology0.46951598
113MP0003938_abnormal_ear_development0.46562218
114MP0000534_abnormal_ureter_morphology0.44029427
115MP0002081_perinatal_lethality0.43099292

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.97457411
2Myokymia (HP:0002411)7.60544805
3Focal seizures (HP:0007359)6.07202463
4Visual hallucinations (HP:0002367)5.66493433
5Action tremor (HP:0002345)5.22840205
6Progressive cerebellar ataxia (HP:0002073)5.15057137
7Febrile seizures (HP:0002373)4.93008254
8Epileptic encephalopathy (HP:0200134)4.72580500
9Atonic seizures (HP:0010819)4.64301058
10Gaze-evoked nystagmus (HP:0000640)4.31632852
11Absence seizures (HP:0002121)4.04120482
12Poor eye contact (HP:0000817)4.01870931
13Cerebral hypomyelination (HP:0006808)3.96867005
14Generalized tonic-clonic seizures (HP:0002069)3.91099275
15Limb dystonia (HP:0002451)3.88737463
16Broad-based gait (HP:0002136)3.77349796
17Dialeptic seizures (HP:0011146)3.70515666
18Dysdiadochokinesis (HP:0002075)3.66138329
19Dysmetria (HP:0001310)3.56811178
20Impaired social interactions (HP:0000735)3.56202987
21Abnormal social behavior (HP:0012433)3.56202987
22Supranuclear gaze palsy (HP:0000605)3.55925624
23Abnormality of the lower motor neuron (HP:0002366)3.47523012
24Scanning speech (HP:0002168)3.40339937
25Impaired smooth pursuit (HP:0007772)3.37847869
26Delusions (HP:0000746)3.33976116
27Impaired vibration sensation in the lower limbs (HP:0002166)3.28961572
28Depression (HP:0000716)3.24063411
29Hemiplegia (HP:0002301)3.22608649
30Intention tremor (HP:0002080)3.17737692
31Ankle clonus (HP:0011448)3.16361053
32Truncal ataxia (HP:0002078)3.12617790
33Akinesia (HP:0002304)3.09761191
34Postural instability (HP:0002172)3.06602897
35Abnormality of ocular smooth pursuit (HP:0000617)3.05700791
36Genetic anticipation (HP:0003743)3.04162230
37Annular pancreas (HP:0001734)3.03707524
38Anxiety (HP:0000739)3.03447883
39Dysmetric saccades (HP:0000641)2.99984114
40Hemiparesis (HP:0001269)2.98054245
41Diplopia (HP:0000651)2.97367995
42Abnormality of binocular vision (HP:0011514)2.97367995
43Amblyopia (HP:0000646)2.94734570
44Abnormal eating behavior (HP:0100738)2.92645168
45Urinary bladder sphincter dysfunction (HP:0002839)2.80287148
46Bundle branch block (HP:0011710)2.74465249
47Ventricular fibrillation (HP:0001663)2.73900488
48Status epilepticus (HP:0002133)2.72658906
49Mutism (HP:0002300)2.63026224
50Spastic gait (HP:0002064)2.57154576
51Stereotypic behavior (HP:0000733)2.55434023
52Torticollis (HP:0000473)2.54171919
53Papilledema (HP:0001085)2.51355896
54Sleep apnea (HP:0010535)2.49415136
55Focal dystonia (HP:0004373)2.44021523
56Polyphagia (HP:0002591)2.43963713
57Hyperventilation (HP:0002883)2.43771255
58Urinary urgency (HP:0000012)2.42216752
59Bradykinesia (HP:0002067)2.40164669
60Peripheral hypomyelination (HP:0007182)2.37387813
61Neurofibrillary tangles (HP:0002185)2.36336439
62Pointed chin (HP:0000307)2.35087687
63Hypoventilation (HP:0002791)2.29294180
64Achilles tendon contracture (HP:0001771)2.29068720
65Tetraplegia (HP:0002445)2.27480693
66Drooling (HP:0002307)2.26487888
67Excessive salivation (HP:0003781)2.26487888
68Cerebral inclusion bodies (HP:0100314)2.24914486
69Impaired vibratory sensation (HP:0002495)2.23881678
70CNS hypomyelination (HP:0003429)2.22151480
71Abnormality of saccadic eye movements (HP:0000570)2.21857619
72Epileptiform EEG discharges (HP:0011182)2.17136158
73Neuronal loss in central nervous system (HP:0002529)2.16758040
74Gait ataxia (HP:0002066)2.15963772
75Lower limb asymmetry (HP:0100559)2.13796999
76Abnormality of the corticospinal tract (HP:0002492)2.13281710
77EEG with generalized epileptiform discharges (HP:0011198)2.08763462
78Progressive inability to walk (HP:0002505)2.08755642
79Megalencephaly (HP:0001355)2.08730806
80Craniofacial dystonia (HP:0012179)2.08362584
81Type II lissencephaly (HP:0007260)2.05225711
82Apathy (HP:0000741)2.04916640
83Abnormality of the Achilles tendon (HP:0005109)2.04670160
84Postural tremor (HP:0002174)2.04654739
85Fetal akinesia sequence (HP:0001989)2.03638206
86Absent speech (HP:0001344)2.02656362
87Hypsarrhythmia (HP:0002521)2.01796523
88Insomnia (HP:0100785)1.99011641
89Clonus (HP:0002169)1.98949950
90Aplasia involving bones of the upper limbs (HP:0009823)1.98267238
91Aplasia of the phalanges of the hand (HP:0009802)1.98267238
92Aplasia involving bones of the extremities (HP:0009825)1.98267238
93Amyotrophic lateral sclerosis (HP:0007354)1.98068077
94Incomplete penetrance (HP:0003829)1.97698022
95Lower limb amyotrophy (HP:0007210)1.97493890
96Agitation (HP:0000713)1.96968491
97Termporal pattern (HP:0011008)1.94932539
98Insidious onset (HP:0003587)1.94932539
99Horizontal nystagmus (HP:0000666)1.92035854
100Limb ataxia (HP:0002070)1.90958947
101Lower limb muscle weakness (HP:0007340)1.89606857
102Abnormal EKG (HP:0003115)1.89373727
103Morphological abnormality of the pyramidal tract (HP:0002062)1.87769708
104Psychosis (HP:0000709)1.86335267
105Rigidity (HP:0002063)1.85393335
106Metabolic alkalosis (HP:0200114)1.84745862
107Morphological abnormality of the inner ear (HP:0011390)1.84479006
108Turricephaly (HP:0000262)1.84054362
109Increased circulating renin level (HP:0000848)1.83568346
110Spastic tetraparesis (HP:0001285)1.83533928
111Choreoathetosis (HP:0001266)1.82043263
112Generalized myoclonic seizures (HP:0002123)1.81835448
113Memory impairment (HP:0002354)1.81453089
114Diminished motivation (HP:0000745)1.80668010
115Spinal canal stenosis (HP:0003416)1.78212815
116Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.77781525
117Degeneration of the lateral corticospinal tracts (HP:0002314)1.77781525
118Shoulder girdle muscle weakness (HP:0003547)1.75976747
119Resting tremor (HP:0002322)1.75754931
120Bronchomalacia (HP:0002780)1.74580906
121Obstructive sleep apnea (HP:0002870)1.74299734
122Intellectual disability, profound (HP:0002187)1.71831618
123Split foot (HP:0001839)1.71766240
124Rapidly progressive (HP:0003678)1.68007264
125Abnormality of the periventricular white matter (HP:0002518)1.64315464

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.03985307
2EPHA44.78099743
3MAP3K93.73929735
4MAP3K42.82393104
5DAPK22.78262323
6MINK12.55194772
7CAMKK12.37148198
8PAK62.31102585
9KSR22.25679285
10MAP2K72.17182772
11PRKD32.14856456
12MARK12.08526885
13CAMKK22.06926770
14RIPK42.06418689
15NTRK22.02042671
16STK381.81901632
17MAP2K41.78117724
18NTRK11.60566885
19CDK51.56261836
20TNIK1.55105325
21PRPF4B1.54306504
22DAPK11.52120301
23MAP3K131.51796840
24MAPK121.51693255
25KSR11.42570597
26CDK191.42112784
27ARAF1.39440181
28FES1.38471162
29SIK21.33926581
30GRK51.32470523
31TYRO31.28543719
32PRKCG1.26834504
33MAP3K121.22852266
34MAP3K21.21230283
35CAMK11.20947232
36PLK21.19527321
37RIPK11.16126637
38PINK11.14125123
39PNCK1.06115563
40UHMK11.04677536
41PRKCH1.04015052
42MAPK131.03995949
43SGK4940.96683307
44SGK2230.96683307
45ALK0.96084216
46PTK2B0.95635342
47CAMK2A0.94821225
48PKN10.94644944
49STK110.93159894
50CDK150.92947960
51WNK10.92754486
52CDK180.91775241
53TAOK10.91391644
54CAMK2B0.91252384
55RET0.84268852
56CDK140.83890380
57CDK11A0.81873529
58OXSR10.79942279
59SGK20.79923923
60SGK10.79825104
61RAF10.79533890
62PDK10.77421051
63SGK30.75420145
64LMTK20.75061794
65PHKG20.73895770
66PHKG10.73895770
67MARK20.73478001
68CASK0.72138360
69PDPK10.71660307
70BMPR20.69680180
71DYRK1A0.69190492
72TNK20.68971184
73CAMK40.66851979
74CAMK1G0.66373297
75CDC42BPA0.63524345
76LIMK10.63331118
77CAMK2D0.62132179
78MAP2K60.61520667
79MAP3K70.60428889
80MAP3K10.59948611
81FGFR20.58898376
82CAMK2G0.58169615
83LATS20.58080652
84PAK30.57818088
85RPS6KA30.55387004
86NEK60.54608140
87ROCK10.50804314
88FYN0.49947069
89CDK30.49508383
90MAPKAPK50.46145209
91MAP3K110.46001559
92MAP2K10.45138376
93FER0.44786688
94MAPK100.43511827
95PRKCZ0.42565050
96ERBB20.42133682
97PRKCE0.41677252
98CSNK1G20.41020478
99DAPK30.38694799
100PRKCB0.37650659
101PDGFRA0.36249725
102BRSK10.34166433
103PRKCA0.34157047
104DMPK0.34109467
105PRKG10.31789830
106PRKD20.31746185
107BRAF0.31305054
108CSNK1A10.30031051
109NEK10.29380640
110ROCK20.29236641
111MAPK80.28378361
112CCNB10.27780224
113SRC0.27230417
114CSNK1E0.26125386
115RPS6KB10.25859221

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.03326686
2Synaptic vesicle cycle_Homo sapiens_hsa047213.14069694
3Long-term potentiation_Homo sapiens_hsa047203.01067091
4Glutamatergic synapse_Homo sapiens_hsa047242.95722672
5Circadian entrainment_Homo sapiens_hsa047132.87094892
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.78183781
7GABAergic synapse_Homo sapiens_hsa047272.73827154
8Olfactory transduction_Homo sapiens_hsa047402.61703880
9Amphetamine addiction_Homo sapiens_hsa050312.59724866
10Morphine addiction_Homo sapiens_hsa050322.47850674
11Salivary secretion_Homo sapiens_hsa049702.21115042
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18235987
13Dopaminergic synapse_Homo sapiens_hsa047282.11691777
14Long-term depression_Homo sapiens_hsa047302.04498905
15Insulin secretion_Homo sapiens_hsa049111.95216461
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.94559130
17Gastric acid secretion_Homo sapiens_hsa049711.92678262
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.87709629
19Taste transduction_Homo sapiens_hsa047421.85743543
20Cholinergic synapse_Homo sapiens_hsa047251.85213366
21Cocaine addiction_Homo sapiens_hsa050301.70093437
22Oxytocin signaling pathway_Homo sapiens_hsa049211.66961549
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66169466
24Calcium signaling pathway_Homo sapiens_hsa040201.63311349
25Renin secretion_Homo sapiens_hsa049241.51415352
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51015327
27GnRH signaling pathway_Homo sapiens_hsa049121.45158293
28Serotonergic synapse_Homo sapiens_hsa047261.42458296
29Nitrogen metabolism_Homo sapiens_hsa009101.35596462
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34599489
31cAMP signaling pathway_Homo sapiens_hsa040241.34380552
32Type II diabetes mellitus_Homo sapiens_hsa049301.32612582
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27237678
34Gap junction_Homo sapiens_hsa045401.21935207
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18211097
36Vitamin B6 metabolism_Homo sapiens_hsa007501.15331560
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12702824
38Collecting duct acid secretion_Homo sapiens_hsa049661.12219689
39Estrogen signaling pathway_Homo sapiens_hsa049151.11105236
40Pancreatic secretion_Homo sapiens_hsa049721.01556634
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01499298
42Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.01353175
43Glioma_Homo sapiens_hsa052141.00218671
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99247319
45Axon guidance_Homo sapiens_hsa043600.93481659
46ErbB signaling pathway_Homo sapiens_hsa040120.92216055
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92158270
48Melanogenesis_Homo sapiens_hsa049160.91583427
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.91551067
50Cardiac muscle contraction_Homo sapiens_hsa042600.90401426
51Oocyte meiosis_Homo sapiens_hsa041140.89164332
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.87655118
53Thyroid hormone synthesis_Homo sapiens_hsa049180.86147007
54Vibrio cholerae infection_Homo sapiens_hsa051100.80236979
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77408644
56Choline metabolism in cancer_Homo sapiens_hsa052310.74570581
57Dorso-ventral axis formation_Homo sapiens_hsa043200.73977842
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72210664
59Dilated cardiomyopathy_Homo sapiens_hsa054140.69278521
60MAPK signaling pathway_Homo sapiens_hsa040100.66949139
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64871096
62Inositol phosphate metabolism_Homo sapiens_hsa005620.64633247
63Bile secretion_Homo sapiens_hsa049760.62691848
64Arginine biosynthesis_Homo sapiens_hsa002200.62497801
65VEGF signaling pathway_Homo sapiens_hsa043700.61436982
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.60403263
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58177978
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54677300
69Glucagon signaling pathway_Homo sapiens_hsa049220.52555199
70mTOR signaling pathway_Homo sapiens_hsa041500.51825282
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51255585
72Rap1 signaling pathway_Homo sapiens_hsa040150.50896986
73Circadian rhythm_Homo sapiens_hsa047100.47777940
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47529342
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.45181218
76Ras signaling pathway_Homo sapiens_hsa040140.45052678
77Endocytosis_Homo sapiens_hsa041440.44310199
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43087115
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41119603
80Type I diabetes mellitus_Homo sapiens_hsa049400.40533967
81Phototransduction_Homo sapiens_hsa047440.39177055
82Alcoholism_Homo sapiens_hsa050340.38636028
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38542186
84Non-small cell lung cancer_Homo sapiens_hsa052230.38228611
85Arginine and proline metabolism_Homo sapiens_hsa003300.36853732
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36543258
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36261902
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35470585
89AMPK signaling pathway_Homo sapiens_hsa041520.34585311
90African trypanosomiasis_Homo sapiens_hsa051430.34244909
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32589125
92Chemokine signaling pathway_Homo sapiens_hsa040620.31700950
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.31671999
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30533324
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.30137269
96Insulin signaling pathway_Homo sapiens_hsa049100.29844849
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29218986
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29118381
99Ovarian steroidogenesis_Homo sapiens_hsa049130.29018197
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28859252
101Prion diseases_Homo sapiens_hsa050200.28503389
102Mineral absorption_Homo sapiens_hsa049780.28243141
103Endometrial cancer_Homo sapiens_hsa052130.27824051
104Hippo signaling pathway_Homo sapiens_hsa043900.27784718
105Wnt signaling pathway_Homo sapiens_hsa043100.27454458
106Histidine metabolism_Homo sapiens_hsa003400.25636472
107Fatty acid biosynthesis_Homo sapiens_hsa000610.25339024
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.23622902
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23229795
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.22251602
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22020067

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »