RNF113A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene encodes a protein which contains a C3H1-type zinc finger domain and a C3HC4 Ring-type (Really Interesting New Gene-type) zinc finger domain. The Ring-type zinc finger domain is identified in various tumor suppressors, DNA repair genes and cytokine receptor-associated molecules, and is probably involved in mediating protein-protein interactions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.89820018
2tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.68312573
3RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.68312573
4positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.63690423
5mannosylation (GO:0097502)3.60774063
6proteasome assembly (GO:0043248)3.55652473
7cytidine deamination (GO:0009972)3.47830046
8cytidine metabolic process (GO:0046087)3.47830046
9cytidine catabolic process (GO:0006216)3.47830046
10metallo-sulfur cluster assembly (GO:0031163)3.47812147
11iron-sulfur cluster assembly (GO:0016226)3.47812147
12immunoglobulin mediated immune response (GO:0016064)3.47258200
13response to interferon-beta (GO:0035456)3.36165612
14regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.36008756
15respiratory chain complex IV assembly (GO:0008535)3.31272494
16protein complex biogenesis (GO:0070271)3.30975245
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.27874245
18pseudouridine synthesis (GO:0001522)3.25202470
19rRNA modification (GO:0000154)3.19749447
20positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.19268198
21negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.17832579
22DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.16835867
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.15678561
24regulation of cellular amino acid metabolic process (GO:0006521)3.13482683
25mitochondrial respiratory chain complex assembly (GO:0033108)3.11982641
26deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.11136502
27pyrimidine ribonucleoside catabolic process (GO:0046133)3.10888757
28antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.09193791
29chaperone-mediated protein transport (GO:0072321)3.08453477
30intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.05234127
31signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.05234127
32mitochondrial respiratory chain complex I assembly (GO:0032981)3.02395708
33NADH dehydrogenase complex assembly (GO:0010257)3.02395708
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.02395708
35signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.02245593
36signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.02245593
37signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.02245593
38negative regulation of ligase activity (GO:0051352)3.01895804
39negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.01895804
40protein deneddylation (GO:0000338)3.01622681
41cytochrome complex assembly (GO:0017004)3.01345805
42B cell mediated immunity (GO:0019724)3.01034355
43Arp2/3 complex-mediated actin nucleation (GO:0034314)2.96491686
44regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.96218545
45preassembly of GPI anchor in ER membrane (GO:0016254)2.93933742
46signal transduction involved in DNA damage checkpoint (GO:0072422)2.89949271
47signal transduction involved in DNA integrity checkpoint (GO:0072401)2.89949271
48negative regulation of B cell apoptotic process (GO:0002903)2.89283079
49regulation of mitochondrial translation (GO:0070129)2.87309652
50regulation of retinoic acid receptor signaling pathway (GO:0048385)2.85237117
51signal transduction involved in cell cycle checkpoint (GO:0072395)2.84143958
52positive regulation of gamma-delta T cell activation (GO:0046645)2.82456118
53positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.82085798
54adenosine metabolic process (GO:0046085)2.81863188
55protein maturation by protein folding (GO:0022417)2.81445380
56protein targeting to mitochondrion (GO:0006626)2.79410110
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.79321259
58cellular response to interferon-beta (GO:0035458)2.78179944
59regulation of B cell receptor signaling pathway (GO:0050855)2.78150354
60positive regulation of B cell differentiation (GO:0045579)2.77956541
61termination of RNA polymerase III transcription (GO:0006386)2.75324943
62transcription elongation from RNA polymerase III promoter (GO:0006385)2.75324943
63GMP metabolic process (GO:0046037)2.74604009
64positive regulation of ligase activity (GO:0051351)2.72521368
65tRNA processing (GO:0008033)2.68806453
66antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.64402060
67chaperone mediated protein folding requiring cofactor (GO:0051085)2.61144821
68establishment of protein localization to mitochondrion (GO:0072655)2.58366379
69autophagic vacuole fusion (GO:0000046)2.57818951
70neutrophil activation involved in immune response (GO:0002283)2.56430541
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.55430475
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.53493681
73piRNA metabolic process (GO:0034587)2.53129884
74organelle membrane fusion (GO:0090174)2.52502157
75protein localization to mitochondrion (GO:0070585)2.51525394
76mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.50670233
77regulation of B cell apoptotic process (GO:0002902)2.49897538
78activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.49536670
79tRNA modification (GO:0006400)2.49111598
80cullin deneddylation (GO:0010388)2.48451884
81actin nucleation (GO:0045010)2.48255127
82energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.46945422
83ATP hydrolysis coupled proton transport (GO:0015991)2.46945422
84positive regulation of protein homooligomerization (GO:0032464)2.46130901
85C-terminal protein lipidation (GO:0006501)2.42872323
86rRNA methylation (GO:0031167)2.42179791
87nucleotide salvage (GO:0043173)2.41062212
88protein-cofactor linkage (GO:0018065)2.40794021
89GPI anchor biosynthetic process (GO:0006506)2.40773208
90mitochondrial RNA metabolic process (GO:0000959)2.40704077
91DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.40473755
92purine deoxyribonucleotide catabolic process (GO:0009155)2.39884422
93positive regulation of cell cycle arrest (GO:0071158)2.39545584
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.37715747
95negative T cell selection (GO:0043383)2.37392881
96regulation of ubiquitin-protein transferase activity (GO:0051438)2.36075884
97mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.34841017
98peptidyl-histidine modification (GO:0018202)2.34359538
99purine-containing compound salvage (GO:0043101)2.33448149
100respiratory electron transport chain (GO:0022904)2.33313762

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.04532977
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.01793183
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.97090020
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.70606651
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.66256773
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.40634543
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.39252529
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.37303871
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.14339290
10VDR_23849224_ChIP-Seq_CD4+_Human2.87010300
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79393534
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.76377521
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.60860554
14FOXP3_21729870_ChIP-Seq_TREG_Human2.60747038
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.59083061
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40421390
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.36372351
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.29376986
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.28330360
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.27288759
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.27098733
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.22420101
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.21507403
24CIITA_25753668_ChIP-Seq_RAJI_Human2.16034013
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15806592
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07406148
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05676295
28GABP_19822575_ChIP-Seq_HepG2_Human2.04778050
29HOXB4_20404135_ChIP-ChIP_EML_Mouse2.01683918
30MYC_18555785_ChIP-Seq_MESCs_Mouse2.00917574
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.96898120
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91702699
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.90872276
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.89035192
35DCP1A_22483619_ChIP-Seq_HELA_Human1.87937027
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.84616923
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.81446457
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77095625
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74521713
40SPI1_23547873_ChIP-Seq_NB4_Human1.74343466
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.69930368
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66229357
43MYB_26560356_Chip-Seq_TH2_Human1.59631776
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.59128756
45XRN2_22483619_ChIP-Seq_HELA_Human1.56844185
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.56287897
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53319811
48ELK1_19687146_ChIP-ChIP_HELA_Human1.51565570
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.51337519
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46849794
51KDM5A_27292631_Chip-Seq_BREAST_Human1.46443844
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.45318724
53MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.44946495
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44276055
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43911297
56STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.40009774
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.39903590
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39851568
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39013427
60TTF2_22483619_ChIP-Seq_HELA_Human1.38557980
61CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37338066
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36228390
63TFEB_21752829_ChIP-Seq_HELA_Human1.34540606
64MYB_26560356_Chip-Seq_TH1_Human1.27417941
65FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26921973
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26662353
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24199265
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22295104
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19929452
70UTX_26944678_Chip-Seq_JUKART_Human1.17057753
71MAF_26560356_Chip-Seq_TH2_Human1.16390275
72GATA3_26560356_Chip-Seq_TH2_Human1.12781347
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11658460
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10007426
75BCL6_27268052_Chip-Seq_Bcells_Human1.08782921
76E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08721234
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07984685
78ZNF274_21170338_ChIP-Seq_K562_Hela1.06901058
79GATA3_27048872_Chip-Seq_THYMUS_Human1.01637218
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00250578
81VDR_21846776_ChIP-Seq_THP-1_Human0.96263046
82ELF1_20517297_ChIP-Seq_JURKAT_Human0.95632642
83MAF_26560356_Chip-Seq_TH1_Human0.94354363
84LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93661761
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93360072
86MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92615850
87MYC_18940864_ChIP-ChIP_HL60_Human0.90775806
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90598863
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90560869
90SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89266023
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88986244
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88706655
93EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88418197
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87651181
95YY1_22570637_ChIP-Seq_MALME-3M_Human0.87387455
96IRF1_19129219_ChIP-ChIP_H3396_Human0.87347809
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.87280636
98PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.85220181
99TP53_22573176_ChIP-Seq_HFKS_Human0.84274427
100P300_27268052_Chip-Seq_Bcells_Human0.83812416

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.50568337
2MP0001835_abnormal_antigen_presentation2.99963212
3MP0003806_abnormal_nucleotide_metabolis2.75123815
4MP0009333_abnormal_splenocyte_physiolog2.61292739
5MP0005000_abnormal_immune_tolerance2.45326683
6MP0001800_abnormal_humoral_immune2.37581896
7MP0003763_abnormal_thymus_physiology2.37152836
8MP0002148_abnormal_hypersensitivity_rea2.33962481
9MP0001986_abnormal_taste_sensitivity2.32260540
10MP0003724_increased_susceptibility_to2.31557865
11MP0008058_abnormal_DNA_repair2.25185470
12MP0001790_abnormal_immune_system2.17085165
13MP0005387_immune_system_phenotype2.17085165
14MP0002723_abnormal_immune_serum2.16271340
15MP0003786_premature_aging2.13590056
16MP0002420_abnormal_adaptive_immunity2.12325981
17MP0009785_altered_susceptibility_to2.10030145
18MP0001819_abnormal_immune_cell2.08157524
19MP0008877_abnormal_DNA_methylation2.06683420
20MP0002452_abnormal_antigen_presenting2.04831143
21MP0003436_decreased_susceptibility_to1.95878412
22MP0005025_abnormal_response_to1.93200391
23MP0003693_abnormal_embryo_hatching1.92407573
24MP0000685_abnormal_immune_system1.92158932
25MP0006036_abnormal_mitochondrial_physio1.89061241
26MP0002398_abnormal_bone_marrow1.86045736
27MP0002138_abnormal_hepatobiliary_system1.85169047
28MP0000372_irregular_coat_pigmentation1.83901733
29MP0005075_abnormal_melanosome_morpholog1.81128579
30MP0000689_abnormal_spleen_morphology1.79556695
31MP0002419_abnormal_innate_immunity1.74273021
32MP0000716_abnormal_immune_system1.70413369
33MP0002722_abnormal_immune_system1.64302947
34MP0001764_abnormal_homeostasis1.58476553
35MP0005360_urolithiasis1.50899489
36MP0005464_abnormal_platelet_physiology1.49212388
37MP0003186_abnormal_redox_activity1.49118711
38MP0002429_abnormal_blood_cell1.49001905
39MP0006035_abnormal_mitochondrial_morpho1.47310796
40MP0008007_abnormal_cellular_replicative1.45796043
41MP0008260_abnormal_autophagy1.45211497
42MP0001845_abnormal_inflammatory_respons1.43855684
43MP0000703_abnormal_thymus_morphology1.43626623
44MP0002405_respiratory_system_inflammati1.39306779
45MP0009840_abnormal_foam_cell1.37304497
46MP0006082_CNS_inflammation1.37026784
47MP0000465_gastrointestinal_hemorrhage1.35412492
48MP0002277_abnormal_respiratory_mucosa1.30973799
49MP0002139_abnormal_hepatobiliary_system1.30570560
50MP0008469_abnormal_protein_level1.30290323
51MP0003718_maternal_effect1.29700058
52MP0002132_abnormal_respiratory_system1.27492106
53MP0002102_abnormal_ear_morphology1.26706825
54MP0003111_abnormal_nucleus_morphology1.26631388
55MP0003787_abnormal_imprinting1.26321242
56MP0004147_increased_porphyrin_level1.24038709
57MP0003866_abnormal_defecation1.23867001
58MP0005058_abnormal_lysosome_morphology1.14641818
59MP0001853_heart_inflammation1.14629301
60MP0000015_abnormal_ear_pigmentation1.13910066
61MP0001968_abnormal_touch/_nociception1.13139964
62MP0003183_abnormal_peptide_metabolism1.11531497
63MP0001905_abnormal_dopamine_level1.09179238
64MP0008995_early_reproductive_senescence1.08403328
65MP0010094_abnormal_chromosome_stability1.07365201
66MP0003172_abnormal_lysosome_physiology1.06837613
67MP0002019_abnormal_tumor_incidence1.03632390
68MP0010155_abnormal_intestine_physiology1.03064095
69MP0002163_abnormal_gland_morphology1.01188864
70MP0009764_decreased_sensitivity_to1.00459676
71MP0008873_increased_physiological_sensi1.00436172
72MP0009765_abnormal_xenobiotic_induced0.99639235
73MP0002166_altered_tumor_susceptibility0.97965533
74MP0005084_abnormal_gallbladder_morpholo0.96721779
75MP0002396_abnormal_hematopoietic_system0.94868936
76MP0003077_abnormal_cell_cycle0.92411767
77MP0001727_abnormal_embryo_implantation0.90336595
78MP0001873_stomach_inflammation0.89994436
79MP0004957_abnormal_blastocyst_morpholog0.88945475
80MP0000358_abnormal_cell_content/0.88159044
81MP0001919_abnormal_reproductive_system0.88119024
82MP0005319_abnormal_enzyme/_coenzyme0.88084097
83MP0003191_abnormal_cellular_cholesterol0.87557486
84MP0002693_abnormal_pancreas_physiology0.84115221
85MP0001529_abnormal_vocalization0.83567839
86MP0005645_abnormal_hypothalamus_physiol0.82968444
87MP0005389_reproductive_system_phenotype0.82619528
88MP0005367_renal/urinary_system_phenotyp0.81593724
89MP0000516_abnormal_urinary_system0.81593724
90MP0009763_increased_sensitivity_to0.80173004
91MP0002736_abnormal_nociception_after0.78802275
92MP0003656_abnormal_erythrocyte_physiolo0.78346805
93MP0005310_abnormal_salivary_gland0.78332294
94MP0000490_abnormal_crypts_of0.76855675
95MP0001929_abnormal_gametogenesis0.76422135
96MP0002006_tumorigenesis0.76166646
97MP0002095_abnormal_skin_pigmentation0.75317910
98MP0008872_abnormal_physiological_respon0.72818195
99MP0009643_abnormal_urine_homeostasis0.72659289
100MP0005397_hematopoietic_system_phenotyp0.72340481

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.07625967
2Stomatitis (HP:0010280)3.69689029
3Abnormal mitochondria in muscle tissue (HP:0008316)3.67606857
4Hepatocellular necrosis (HP:0001404)3.55160396
5Decreased activity of mitochondrial respiratory chain (HP:0008972)3.43340155
6Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.43340155
7Hepatic necrosis (HP:0002605)3.43295258
8Mitochondrial inheritance (HP:0001427)3.42733451
9Acute necrotizing encephalopathy (HP:0006965)3.41246871
10Increased CSF lactate (HP:0002490)3.39130135
11Recurrent abscess formation (HP:0002722)3.11111207
12Recurrent bacterial skin infections (HP:0005406)3.09506882
13Elevated erythrocyte sedimentation rate (HP:0003565)3.05856788
14Acute encephalopathy (HP:0006846)2.95873646
15Progressive macrocephaly (HP:0004481)2.87389796
16Pancytopenia (HP:0001876)2.84713479
17Type I transferrin isoform profile (HP:0003642)2.77978705
18IgG deficiency (HP:0004315)2.75747436
19Reduced antithrombin III activity (HP:0001976)2.70361847
20Increased serum lactate (HP:0002151)2.68448630
21Methylmalonic aciduria (HP:0012120)2.67525748
22Increased intramyocellular lipid droplets (HP:0012240)2.66907742
23Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.66829554
24Abnormal protein N-linked glycosylation (HP:0012347)2.66829554
25Abnormal protein glycosylation (HP:0012346)2.66829554
26Abnormal glycosylation (HP:0012345)2.66829554
27Lactic acidosis (HP:0003128)2.66566205
28Methylmalonic acidemia (HP:0002912)2.65068567
29Abnormal gallbladder physiology (HP:0012438)2.61761321
30Cholecystitis (HP:0001082)2.61761321
31Abnormality of B cell number (HP:0010975)2.59288453
32B lymphocytopenia (HP:0010976)2.57865749
33Ragged-red muscle fibers (HP:0003200)2.56278060
34Abnormality of T cells (HP:0002843)2.55180485
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.54120683
36Agammaglobulinemia (HP:0004432)2.52998432
37Severe combined immunodeficiency (HP:0004430)2.52965804
38Petechiae (HP:0000967)2.52893230
39Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.51603718
403-Methylglutaconic aciduria (HP:0003535)2.41086777
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40174880
42Abnormality of macrophages (HP:0004311)2.38360007
43Increased IgM level (HP:0003496)2.37210901
44Dicarboxylic aciduria (HP:0003215)2.35963238
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.35963238
46Increased muscle lipid content (HP:0009058)2.34287629
47IgM deficiency (HP:0002850)2.33494564
48Prostate neoplasm (HP:0100787)2.31885106
49Abnormality of T cell physiology (HP:0011840)2.30869162
50Abnormality of the prostate (HP:0008775)2.29698792
51Panhypogammaglobulinemia (HP:0003139)2.23537734
52Progressive microcephaly (HP:0000253)2.22965965
53Generalized aminoaciduria (HP:0002909)2.22946839
54Exercise intolerance (HP:0003546)2.22338046
55Neutropenia (HP:0001875)2.21429314
56T lymphocytopenia (HP:0005403)2.20869897
57Recurrent fungal infections (HP:0002841)2.18925549
58Hypokinesia (HP:0002375)2.17822929
59Cerebral edema (HP:0002181)2.17245248
60Oral leukoplakia (HP:0002745)2.17099683
61Autoimmune hemolytic anemia (HP:0001890)2.16190769
62Abnormality of T cell number (HP:0011839)2.15598446
63Granulocytopenia (HP:0001913)2.14728068
64Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14249275
65Abnormality of alanine metabolism (HP:0010916)2.14249275
66Hyperalaninemia (HP:0003348)2.14249275
67Obstructive lung disease (HP:0006536)2.10888919
68Chronic obstructive pulmonary disease (HP:0006510)2.10888919
69Recurrent cutaneous fungal infections (HP:0011370)2.10514769
70Chronic mucocutaneous candidiasis (HP:0002728)2.10514769
71Combined immunodeficiency (HP:0005387)2.09475752
72Recurrent viral infections (HP:0004429)2.08979364
73Meningitis (HP:0001287)2.05452870
74Microvesicular hepatic steatosis (HP:0001414)2.03663478
75Respiratory failure (HP:0002878)1.99627625
76Constricted visual fields (HP:0001133)1.99293852
77Abnormal delayed hypersensitivity skin test (HP:0002963)1.99091830
78Abnormality of eosinophils (HP:0001879)1.98337504
79Abnormality of the heme biosynthetic pathway (HP:0010472)1.97285660
80Progressive muscle weakness (HP:0003323)1.94586997
81Recurrent skin infections (HP:0001581)1.93871222
82Vacuolated lymphocytes (HP:0001922)1.93033284
83Encephalitis (HP:0002383)1.91422627
84Nausea (HP:0002018)1.90904240
85Increased serum ferritin (HP:0003281)1.90834262
86Mediastinal lymphadenopathy (HP:0100721)1.88603227
87Eosinophilia (HP:0001880)1.88080443
88Chronic diarrhea (HP:0002028)1.87909685
89Type 2 muscle fiber atrophy (HP:0003554)1.87531203
90Tongue fasciculations (HP:0001308)1.87438019
91Lethargy (HP:0001254)1.85416357
92Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85233910
93Emotional lability (HP:0000712)1.85000304
94Lipid accumulation in hepatocytes (HP:0006561)1.84565729
95Renal Fanconi syndrome (HP:0001994)1.83567728
96Rough bone trabeculation (HP:0100670)1.83390052
97Increased hepatocellular lipid droplets (HP:0006565)1.82276895
98Premature ovarian failure (HP:0008209)1.82246355
99Hypergonadotropic hypogonadism (HP:0000815)1.81933381
100Hypoproteinemia (HP:0003075)1.79357711

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.33354900
2TXK3.24491463
3BCKDK3.17330596
4TESK23.11208708
5VRK22.99781290
6TAOK32.87912769
7NME22.34576871
8PDK22.31917375
9NUAK12.30646638
10KDR2.16616963
11FES1.93660172
12BUB11.87598320
13RIPK41.79551214
14TRIM281.77179791
15MAP3K111.73255194
16TESK11.68094969
17PIM21.64837020
18STK161.63223469
19INSRR1.59490496
20GRK61.56982593
21SRPK11.55009412
22VRK11.54497887
23EIF2AK11.54231399
24EIF2AK31.42741788
25MAP3K121.41793060
26CDK191.33525374
27TBK11.29596912
28IKBKB1.23407298
29SYK1.22933334
30MAP4K21.21822987
31TEC1.17605146
32MST41.14692290
33ITK1.13146927
34TNK21.12326834
35CDK91.12240856
36IKBKE1.11836904
37KIT1.11494411
38AURKA1.11380910
39ARAF1.10687816
40LYN1.08111273
41SIK31.07729906
42BTK1.05578332
43DAPK11.05450542
44ZAK1.02815731
45LIMK11.02503622
46TLK10.98431387
47CSNK1G30.93860962
48CCNB10.93521665
49SCYL20.92065548
50IRAK40.90491212
51LCK0.89761683
52JAK30.86884917
53BLK0.86855049
54TYK20.86528963
55MAP3K140.86366767
56CSF1R0.83893273
57PRKCQ0.83023474
58RPS6KA50.82172309
59RPS6KB20.81270946
60ADRBK20.80387737
61MARK30.77940026
62MAPKAPK30.77136142
63MAP2K70.74228028
64MATK0.74055405
65MAP2K20.73007225
66MUSK0.72690812
67PRKCI0.71764908
68GRK10.69906568
69NME10.66701536
70PIK3CG0.65193375
71MAP2K30.63505986
72ATR0.63247300
73PLK40.63139431
74CSNK1A1L0.60754538
75HCK0.60585350
76CSNK2A10.60502847
77PIM10.60042608
78CDK80.59701056
79BRSK10.59576915
80MAP3K30.58313242
81ZAP700.58150788
82RAF10.56330192
83SIK20.55113794
84IRAK30.51645486
85BMPR20.51112529
86MAPK110.49808919
87CSNK1G10.49659731
88MAP3K50.48650367
89CSK0.48597076
90ERN10.47461175
91CSNK1G20.47198768
92GRK70.46860489
93CLK10.45419595
94PAK10.44981400
95* CSNK2A20.44566265
96STK100.44252262
97NEK10.43275381
98FRK0.42962798
99FGR0.41078851
100MAPKAPK50.40940306

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.10559959
2Primary immunodeficiency_Homo sapiens_hsa053403.00838635
3Oxidative phosphorylation_Homo sapiens_hsa001902.70047222
4Allograft rejection_Homo sapiens_hsa053302.45378533
5RNA polymerase_Homo sapiens_hsa030202.40424624
6Protein export_Homo sapiens_hsa030602.35120564
7Parkinsons disease_Homo sapiens_hsa050122.26181632
8Graft-versus-host disease_Homo sapiens_hsa053322.23207411
9Autoimmune thyroid disease_Homo sapiens_hsa053202.21319765
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.20194412
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.19396984
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.16729019
13Type I diabetes mellitus_Homo sapiens_hsa049402.16573521
14Ribosome_Homo sapiens_hsa030102.05183410
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.84430795
16Asthma_Homo sapiens_hsa053101.81396303
17Antigen processing and presentation_Homo sapiens_hsa046121.81034093
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.74425275
19Rheumatoid arthritis_Homo sapiens_hsa053231.74357002
20Collecting duct acid secretion_Homo sapiens_hsa049661.71269498
21Base excision repair_Homo sapiens_hsa034101.68166610
22Regulation of autophagy_Homo sapiens_hsa041401.66206918
23Fatty acid elongation_Homo sapiens_hsa000621.64859051
24Pyrimidine metabolism_Homo sapiens_hsa002401.55881910
25Sulfur relay system_Homo sapiens_hsa041221.53429942
26DNA replication_Homo sapiens_hsa030301.50209862
27RNA degradation_Homo sapiens_hsa030181.36444114
28Huntingtons disease_Homo sapiens_hsa050161.35218712
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31127843
30Spliceosome_Homo sapiens_hsa030401.29909757
31Sulfur metabolism_Homo sapiens_hsa009201.28336383
32Mismatch repair_Homo sapiens_hsa034301.23097716
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22873552
34Basal transcription factors_Homo sapiens_hsa030221.20493138
35Nucleotide excision repair_Homo sapiens_hsa034201.18189108
36Homologous recombination_Homo sapiens_hsa034401.15923760
37RNA transport_Homo sapiens_hsa030131.15302791
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14238948
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13159770
40Herpes simplex infection_Homo sapiens_hsa051681.12357089
41Viral myocarditis_Homo sapiens_hsa054161.11197664
42Alzheimers disease_Homo sapiens_hsa050101.09731078
43Leishmaniasis_Homo sapiens_hsa051401.08768024
44Hematopoietic cell lineage_Homo sapiens_hsa046401.08675554
45Staphylococcus aureus infection_Homo sapiens_hsa051501.07110189
46Fanconi anemia pathway_Homo sapiens_hsa034601.06381948
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04251292
48Folate biosynthesis_Homo sapiens_hsa007901.00184437
49One carbon pool by folate_Homo sapiens_hsa006700.97561325
50Epstein-Barr virus infection_Homo sapiens_hsa051690.92457877
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.92112843
52Systemic lupus erythematosus_Homo sapiens_hsa053220.90806850
53N-Glycan biosynthesis_Homo sapiens_hsa005100.87877721
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87638930
55Purine metabolism_Homo sapiens_hsa002300.85210024
56Legionellosis_Homo sapiens_hsa051340.81786269
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79069551
58Measles_Homo sapiens_hsa051620.78923607
59Vibrio cholerae infection_Homo sapiens_hsa051100.78385079
60Phagosome_Homo sapiens_hsa041450.74632401
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73474973
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72353807
63T cell receptor signaling pathway_Homo sapiens_hsa046600.71046340
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70625977
65Shigellosis_Homo sapiens_hsa051310.70076030
66Tuberculosis_Homo sapiens_hsa051520.68857694
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68487757
68Lysosome_Homo sapiens_hsa041420.67075187
69Galactose metabolism_Homo sapiens_hsa000520.65797548
70Peroxisome_Homo sapiens_hsa041460.64529860
71Selenocompound metabolism_Homo sapiens_hsa004500.61934328
72Glutathione metabolism_Homo sapiens_hsa004800.61173492
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.59799453
74Other glycan degradation_Homo sapiens_hsa005110.58422697
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.58086635
76Non-homologous end-joining_Homo sapiens_hsa034500.57285440
77Metabolic pathways_Homo sapiens_hsa011000.54690556
78Pentose phosphate pathway_Homo sapiens_hsa000300.53502956
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52885693
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49918673
81Osteoclast differentiation_Homo sapiens_hsa043800.49644755
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48862370
83Carbon metabolism_Homo sapiens_hsa012000.48511282
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48109089
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47999677
86Influenza A_Homo sapiens_hsa051640.45977616
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44624313
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43328013
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43280303
90Biosynthesis of amino acids_Homo sapiens_hsa012300.42195526
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.41756130
92Salmonella infection_Homo sapiens_hsa051320.40948979
93Synaptic vesicle cycle_Homo sapiens_hsa047210.40328132
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35979112
95mRNA surveillance pathway_Homo sapiens_hsa030150.34806100
96Arachidonic acid metabolism_Homo sapiens_hsa005900.34708383
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34693325
98Fructose and mannose metabolism_Homo sapiens_hsa000510.34664550
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.34345314
100Apoptosis_Homo sapiens_hsa042100.33725107

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