RNF115

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NIK/NF-kappaB signaling (GO:0038061)6.31309104
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.95744690
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.95744690
4antigen processing and presentation of endogenous antigen (GO:0019883)5.66107801
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.49232454
6muscle filament sliding (GO:0030049)5.28153414
7actin-myosin filament sliding (GO:0033275)5.28153414
8neutrophil activation involved in immune response (GO:0002283)5.17039124
9myofibril assembly (GO:0030239)4.98634025
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.89145579
11sarcoplasmic reticulum calcium ion transport (GO:0070296)4.80539326
12regulation of skeletal muscle contraction (GO:0014819)4.61478916
13interkinetic nuclear migration (GO:0022027)4.59177788
14regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.59060082
15sarcomere organization (GO:0045214)4.56062655
16actin-mediated cell contraction (GO:0070252)4.52090952
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.51552027
18regulation of relaxation of muscle (GO:1901077)4.46824016
19kynurenine metabolic process (GO:0070189)4.42531137
20regulation of RIG-I signaling pathway (GO:0039535)4.31873003
21skeletal muscle adaptation (GO:0043501)4.24829333
22natural killer cell mediated immunity (GO:0002228)4.24372162
23natural killer cell mediated cytotoxicity (GO:0042267)4.24372162
24cardiac myofibril assembly (GO:0055003)4.22774666
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.04000018
26negative regulation of cell killing (GO:0031342)4.04000018
27myeloid dendritic cell differentiation (GO:0043011)3.99933394
28regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.99778805
29positive regulation of natural killer cell differentiation (GO:0032825)3.99022879
30neutrophil activation (GO:0042119)3.98615558
31behavioral response to nicotine (GO:0035095)3.97586340
32positive regulation of gamma-delta T cell activation (GO:0046645)3.95217432
33response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.91614360
34granulocyte activation (GO:0036230)3.90353830
35positive regulation of antigen processing and presentation (GO:0002579)3.89761812
36tryptophan catabolic process (GO:0006569)3.89701059
37indole-containing compound catabolic process (GO:0042436)3.89701059
38indolalkylamine catabolic process (GO:0046218)3.89701059
39striated muscle atrophy (GO:0014891)3.89606282
40regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.83856555
41regulation of dendritic cell antigen processing and presentation (GO:0002604)3.80529963
42regulation of cell communication by electrical coupling (GO:0010649)3.75635119
43regulation of T-helper 1 cell differentiation (GO:0045625)3.67767108
44response to inactivity (GO:0014854)3.63826610
45striated muscle contraction (GO:0006941)3.61143932
46macroautophagy (GO:0016236)3.58034740
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.57620582
48myeloid dendritic cell activation (GO:0001773)3.56327649
49negative thymic T cell selection (GO:0045060)3.56240065
50growth hormone receptor signaling pathway (GO:0060396)3.55552406
51response to caffeine (GO:0031000)3.55378251
52JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.54126942
53regulation of interleukin-12 biosynthetic process (GO:0045075)3.53605183
54necroptotic process (GO:0070266)3.53401352
55cellular response to type I interferon (GO:0071357)3.52960753
56type I interferon signaling pathway (GO:0060337)3.52960753
57regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.50592835
58response to type I interferon (GO:0034340)3.50586174
59cellular ketone body metabolic process (GO:0046950)3.48305810
60antigen processing and presentation via MHC class Ib (GO:0002475)3.45479321
61interferon-gamma-mediated signaling pathway (GO:0060333)3.45013796
62membrane depolarization during action potential (GO:0086010)3.44604105
63immunoglobulin mediated immune response (GO:0016064)3.41186732
64negative regulation of protein localization to cell surface (GO:2000009)3.40978548
65cardiac muscle contraction (GO:0060048)3.39951305
66actomyosin structure organization (GO:0031032)3.39823095
67regulation of hypersensitivity (GO:0002883)3.39396984
68regulation of sarcomere organization (GO:0060297)3.38229908
69Arp2/3 complex-mediated actin nucleation (GO:0034314)3.37785466
70positive regulation of interferon-alpha production (GO:0032727)3.37132477
71positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.36607172
72negative regulation of cytosolic calcium ion concentration (GO:0051481)3.35942313
73negative T cell selection (GO:0043383)3.34260409
74positive regulation of interleukin-12 production (GO:0032735)3.31456713
75regulation of type I interferon-mediated signaling pathway (GO:0060338)3.30579971
76regulation of striated muscle contraction (GO:0006942)3.30065805
77fatty acid transmembrane transport (GO:1902001)3.29795788
78positive regulation by symbiont of host defense response (GO:0052509)3.27964906
79modulation by symbiont of host defense response (GO:0052031)3.27964906
80modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.27964906
81modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.27964906
82positive regulation by organism of defense response of other organism involved in symbiotic interact3.27964906
83modulation by symbiont of host immune response (GO:0052553)3.27964906
84dendritic cell differentiation (GO:0097028)3.27591718
85L-fucose catabolic process (GO:0042355)3.26726275
86fucose catabolic process (GO:0019317)3.26726275
87L-fucose metabolic process (GO:0042354)3.26726275
88regulation of response to interferon-gamma (GO:0060330)3.24924571
89regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.23815050
90positive regulation of B cell differentiation (GO:0045579)3.23567139
91B cell mediated immunity (GO:0019724)3.20871539
92tryptophan metabolic process (GO:0006568)3.18895658
93regulation of interferon-alpha production (GO:0032647)3.18863705
94skeletal muscle contraction (GO:0003009)3.17661166
95T-helper 1 type immune response (GO:0042088)3.16560305
96positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.16246625
97regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.15251524
98indolalkylamine metabolic process (GO:0006586)3.14682160
99muscle atrophy (GO:0014889)3.14591093
100positive regulation of humoral immune response (GO:0002922)3.14376206
101cardiac muscle hypertrophy (GO:0003300)3.14233422
102regulation of antigen processing and presentation (GO:0002577)3.14081428
103regulation of B cell receptor signaling pathway (GO:0050855)3.13306282
104regulation of actin filament-based movement (GO:1903115)3.12944866
105relaxation of cardiac muscle (GO:0055119)3.11143094
106actin filament-based movement (GO:0030048)3.05608751
107regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.04292748
108ketone body metabolic process (GO:1902224)3.03447450
109regulation of membrane repolarization (GO:0060306)3.03340837
110positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.03253606
111leukocyte mediated cytotoxicity (GO:0001909)3.01977951
112positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.98302675
113regulation of interferon-beta biosynthetic process (GO:0045357)2.98277270
114regulation of T cell receptor signaling pathway (GO:0050856)2.97440827
115striated muscle hypertrophy (GO:0014897)2.97106176
116regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.96823245
117negative regulation of interleukin-17 production (GO:0032700)2.95748122
118regulation of necroptotic process (GO:0060544)2.94465767
119cellular response to growth hormone stimulus (GO:0071378)2.94267842
120regulation of B cell differentiation (GO:0045577)2.92794103
121regulation of gamma-delta T cell differentiation (GO:0045586)2.92260126
122natural killer cell differentiation (GO:0001779)2.91498428
123positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.91113906
124T cell migration (GO:0072678)2.90933613
125positive regulation of cation channel activity (GO:2001259)2.90768065
126muscle contraction (GO:0006936)2.89285313
127CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.89192375
128T-helper cell differentiation (GO:0042093)2.89192375
129regulation of energy homeostasis (GO:2000505)2.89166155
130regulation of calcium ion transmembrane transport (GO:1903169)2.88019757
131regulation of calcium ion transmembrane transporter activity (GO:1901019)2.88019757
132positive regulation of T cell cytokine production (GO:0002726)2.87956405
133regulation of establishment of cell polarity (GO:2000114)2.86539985
134oxidative demethylation (GO:0070989)2.85884520
135regulation of hippo signaling (GO:0035330)2.84890061
136mature B cell differentiation (GO:0002335)2.84168018
137respiratory burst (GO:0045730)2.83241727
138regulation of the force of heart contraction (GO:0002026)2.83136917
139regulation of natural killer cell differentiation (GO:0032823)2.82644237
140positive regulation of interleukin-2 production (GO:0032743)2.81019133
141cAMP catabolic process (GO:0006198)2.80962862
142regulation of gamma-delta T cell activation (GO:0046643)2.78618155
143response to peptidoglycan (GO:0032494)2.78425063
144positive regulation of interferon-beta production (GO:0032728)2.77411063
145striated muscle adaptation (GO:0014888)2.77050440
146regulation of interleukin-12 production (GO:0032655)2.76788267
147positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.75777821
148detection of light stimulus involved in sensory perception (GO:0050962)2.75399846
149detection of light stimulus involved in visual perception (GO:0050908)2.75399846
150negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.74729679
151cellular response to zinc ion (GO:0071294)2.74601538
152muscle system process (GO:0003012)2.74386891
153lymphocyte mediated immunity (GO:0002449)2.74316049
154hydrogen peroxide biosynthetic process (GO:0050665)2.74309725
155carnitine shuttle (GO:0006853)2.73962306
156neuronal action potential (GO:0019228)2.73834612
157negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.73479689
158response to interleukin-15 (GO:0070672)2.73362748
159cytokine secretion (GO:0050663)2.73355875
160cardiac muscle cell development (GO:0055013)2.72584426
161myeloid cell activation involved in immune response (GO:0002275)2.72031875
162positive regulation of fatty acid oxidation (GO:0046321)2.71505688
163positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.71331800
164indole-containing compound metabolic process (GO:0042430)2.70754635
165actin nucleation (GO:0045010)2.70101691
166response to muramyl dipeptide (GO:0032495)2.70094354
167NAD biosynthetic process (GO:0009435)2.68752706
168natural killer cell activation (GO:0030101)2.68499069
169muscle fiber development (GO:0048747)2.66742826
170neuronal action potential propagation (GO:0019227)2.66684909
171adult heart development (GO:0007512)2.66564818
172muscle hypertrophy (GO:0014896)2.66454021
173regulation of T cell tolerance induction (GO:0002664)2.65922796
174regulation of cardiac muscle contraction (GO:0055117)2.65867291
175response to interferon-gamma (GO:0034341)2.65789753
176lymphocyte migration (GO:0072676)2.65014194
177primary amino compound metabolic process (GO:1901160)2.64959146
178cyclic nucleotide catabolic process (GO:0009214)2.64927865
179pericardium development (GO:0060039)2.64240477
180positive regulation of protein homooligomerization (GO:0032464)2.63295222
181leukocyte degranulation (GO:0043299)2.63145914
182regulation of action potential (GO:0098900)2.62965027
183positive regulation of sodium ion transmembrane transport (GO:1902307)2.62782869
184establishment of protein localization to Golgi (GO:0072600)2.61306136
185lipopolysaccharide-mediated signaling pathway (GO:0031663)2.61289508
186regulation of establishment or maintenance of cell polarity (GO:0032878)2.60189387
187regulation of immunoglobulin secretion (GO:0051023)2.59829435
188defense response to protozoan (GO:0042832)2.59826928
189cardiac muscle tissue morphogenesis (GO:0055008)2.59627388
190carnitine transmembrane transport (GO:1902603)2.57957968
191protein K63-linked deubiquitination (GO:0070536)2.56393415
192nucleus localization (GO:0051647)2.56041620
193plasma membrane repair (GO:0001778)2.55857501
194serotonin metabolic process (GO:0042428)2.55795080
195skeletal muscle tissue regeneration (GO:0043403)2.53292694
196muscle tissue morphogenesis (GO:0060415)2.53258983
197protein K11-linked deubiquitination (GO:0035871)2.52000206
198positive regulation of heart rate (GO:0010460)2.51285081
199regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.50897731
200histone-serine phosphorylation (GO:0035404)2.49830843

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.08442443
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.96043388
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.27200980
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.74434997
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.41021223
6GBX2_23144817_ChIP-Seq_PC3_Human3.29593799
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.26456924
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.23220491
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.17535344
10GATA1_22025678_ChIP-Seq_K562_Human3.12043584
11EZH2_22144423_ChIP-Seq_EOC_Human3.09151700
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.07302622
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.05998818
14MYB_21317192_ChIP-Seq_ERMYB_Mouse3.01560548
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.92454523
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.88587255
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.71800569
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.71703038
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.66187557
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.63199528
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.62913026
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.59606799
23ZNF274_21170338_ChIP-Seq_K562_Hela2.59466724
24VDR_22108803_ChIP-Seq_LS180_Human2.57411895
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.56635372
26E2F7_22180533_ChIP-Seq_HELA_Human2.44256222
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.36957421
28SPI1_23547873_ChIP-Seq_NB4_Human2.34568251
29ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23848227
30* MYB_26560356_Chip-Seq_TH2_Human2.22414572
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.21018018
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.17670718
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15934680
34* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.13813553
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.11940574
36POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05878012
37FLI1_27457419_Chip-Seq_LIVER_Mouse2.02433927
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.02380410
39TAF15_26573619_Chip-Seq_HEK293_Human1.99219105
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.94565008
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94406684
42* MAF_26560356_Chip-Seq_TH1_Human1.91120823
43ER_23166858_ChIP-Seq_MCF-7_Human1.89758847
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88596666
45* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86489394
46MYB_26560356_Chip-Seq_TH1_Human1.85336249
47MYC_22102868_ChIP-Seq_BL_Human1.83808935
48TFEB_21752829_ChIP-Seq_HELA_Human1.82938551
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.82107064
50RUNX_20019798_ChIP-Seq_JUKART_Human1.78773220
51TP53_16413492_ChIP-PET_HCT116_Human1.76078912
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.75437636
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.74791604
54STAT3_23295773_ChIP-Seq_U87_Human1.74129738
55GATA3_27048872_Chip-Seq_THYMUS_Human1.73082037
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.72080280
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65702277
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64615615
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64604592
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64230680
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61762904
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.61364699
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60935748
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.60834789
65TCF4_23295773_ChIP-Seq_U87_Human1.58677364
66IGF1R_20145208_ChIP-Seq_DFB_Human1.58009059
67* SMAD4_21799915_ChIP-Seq_A2780_Human1.57137768
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56647582
69EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.56093344
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.54850389
71P300_19829295_ChIP-Seq_ESCs_Human1.49023659
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48869901
73DROSHA_22980978_ChIP-Seq_HELA_Human1.48802189
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.46846591
75* GATA3_26560356_Chip-Seq_TH2_Human1.46342668
76PU_27001747_Chip-Seq_BMDM_Mouse1.45824804
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44427011
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44037696
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43165094
80VDR_21846776_ChIP-Seq_THP-1_Human1.42802256
81GATA2_22383799_ChIP-Seq_G1ME_Mouse1.41305283
82AR_21572438_ChIP-Seq_LNCaP_Human1.40978334
83VDR_24763502_ChIP-Seq_THP-1_Human1.40534879
84CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39056819
85UTX_26944678_Chip-Seq_JUKART_Human1.39040784
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38030256
87EWS_26573619_Chip-Seq_HEK293_Human1.37758062
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37001675
89FUS_26573619_Chip-Seq_HEK293_Human1.36693961
90TCF7_22412390_ChIP-Seq_EML_Mouse1.36646050
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36171510
92BCAT_22108803_ChIP-Seq_LS180_Human1.36052078
93EP300_21415370_ChIP-Seq_HL-1_Mouse1.35852299
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35457593
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35411225
96GABP_17652178_ChIP-ChIP_JURKAT_Human1.34616331
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.34347446
98VDR_23849224_ChIP-Seq_CD4+_Human1.33992681
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33820484
100AR_25329375_ChIP-Seq_VCAP_Human1.33402868
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.33104021
102HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32677363
103SPI1_23127762_ChIP-Seq_K562_Human1.32670334
104EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31253736
105CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30580312
106E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30345281
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.30148114
108AHR_22903824_ChIP-Seq_MCF-7_Human1.29407579
109PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28511353
110CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27517163
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27478746
112FLI1_21867929_ChIP-Seq_TH2_Mouse1.25586300
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25477348
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.22548885
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.22479970
116CBP_20019798_ChIP-Seq_JUKART_Human1.22236794
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22236794
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21616770
119CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21204230
120* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20797606
121* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20797606
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20350802
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20350802
124* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19019817
125SCL_19346495_ChIP-Seq_HPC-7_Human1.18427353
126CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17863210
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16917695
128TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16896937
129TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16642667
130SALL1_21062744_ChIP-ChIP_HESCs_Human1.16382149
131GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15973583
132TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15969373
133SOX2_21211035_ChIP-Seq_LN229_Gbm1.14542763
134TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13621532
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12459131
136SMAD3_21741376_ChIP-Seq_EPCs_Human1.11808168
137SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11494577
138REST_21632747_ChIP-Seq_MESCs_Mouse1.10297937
139SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10004214
140OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09835445
141P53_22387025_ChIP-Seq_ESCs_Mouse1.09581974
142MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09165559
143NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.08854756
144SMAD4_21741376_ChIP-Seq_EPCs_Human1.08341287
145MAF_26560356_Chip-Seq_TH2_Human1.07862348
146NANOG_18555785_Chip-Seq_ESCs_Mouse1.07821673
147* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07614812
148LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06571691
149PRDM14_20953172_ChIP-Seq_ESCs_Human1.06467386
150CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06429061
151E2F1_18555785_Chip-Seq_ESCs_Mouse1.06061810
152FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05503459
153ELK1_19687146_ChIP-ChIP_HELA_Human1.05317973
154* CJUN_26792858_Chip-Seq_BT549_Human1.05157167
155SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04478485
156FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03387864
157GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03198729
158FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03188722
159EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03087400
160ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02044641
161TP53_22573176_ChIP-Seq_HFKS_Human1.01615512
162TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01382175
163MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00803241
164SOX2_19829295_ChIP-Seq_ESCs_Human1.00266924
165NANOG_19829295_ChIP-Seq_ESCs_Human1.00266924
166RUNX2_22187159_ChIP-Seq_PCA_Human1.00110684
167TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99886008
168TCF4_22108803_ChIP-Seq_LS180_Human0.99344767
169KDM2B_26808549_Chip-Seq_REH_Human0.98847020
170TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98763258
171KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97817079
172PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97135406
173STAT3_18555785_Chip-Seq_ESCs_Mouse0.97128584
174VDR_24787735_ChIP-Seq_THP-1_Human0.96273639
175ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95634972
176ZNF263_19887448_ChIP-Seq_K562_Human0.94420986
177PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90140683
178PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88779586
179KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86106186
180STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85535269
181GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84318374
182ELK3_25401928_ChIP-Seq_HUVEC_Human0.82560234
183DCP1A_22483619_ChIP-Seq_HELA_Human0.82442901
184PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81392552
185PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81086190
186* KDM2B_26808549_Chip-Seq_DND41_Human0.79149363
187ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.78876438
188PPARA_22158963_ChIP-Seq_LIVER_Mouse0.76797757
189ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74127826
190PADI4_21655091_ChIP-ChIP_MCF-7_Human0.71143432
191NCOR1_26117541_ChIP-Seq_K562_Human0.70783009
192RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.69646715
193E2F1_21310950_ChIP-Seq_MCF-7_Human0.69018041
194LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.68606156
195NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.68434469

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio4.49549922
2MP0004084_abnormal_cardiac_muscle4.25745083
3MP0001835_abnormal_antigen_presentation4.21941075
4MP0002837_dystrophic_cardiac_calcinosis4.09550412
5MP0002138_abnormal_hepatobiliary_system3.93755164
6MP0004036_abnormal_muscle_relaxation3.64163076
7MP0000685_abnormal_immune_system3.42202608
8MP0004130_abnormal_muscle_cell3.35798264
9MP0004215_abnormal_myocardial_fiber3.17047038
10MP0003436_decreased_susceptibility_to3.09960015
11MP0009785_altered_susceptibility_to3.09019449
12MP0000749_muscle_degeneration3.06810713
13MP0000751_myopathy2.92279389
14MP0001790_abnormal_immune_system2.88153997
15MP0005387_immune_system_phenotype2.88153997
16MP0002148_abnormal_hypersensitivity_rea2.85346170
17MP0005671_abnormal_response_to2.81450136
18MP0005000_abnormal_immune_tolerance2.80393432
19MP0002254_reproductive_system_inflammat2.76761311
20MP0000569_abnormal_digit_pigmentation2.59275851
21MP0001800_abnormal_humoral_immune2.56616359
22MP0004510_myositis2.54443117
23MP0002163_abnormal_gland_morphology2.50680774
24MP0005620_abnormal_muscle_contractility2.46391206
25MP0002723_abnormal_immune_serum2.44809823
26MP0002452_abnormal_antigen_presenting2.40662150
27MP0005025_abnormal_response_to2.36127659
28MP0002332_abnormal_exercise_endurance2.32700526
29MP0005310_abnormal_salivary_gland2.32282518
30MP0009840_abnormal_foam_cell2.31467064
31MP0001819_abnormal_immune_cell2.26616264
32MP0002419_abnormal_innate_immunity2.25981981
33MP0002420_abnormal_adaptive_immunity2.24140095
34MP0002106_abnormal_muscle_physiology2.18984819
35MP0002877_abnormal_melanocyte_morpholog2.18718240
36MP0003303_peritoneal_inflammation2.13094053
37MP0002166_altered_tumor_susceptibility2.12917440
38MP0008775_abnormal_heart_ventricle2.11510844
39MP0004043_abnormal_pH_regulation2.05158385
40MP0009046_muscle_twitch2.05072421
41MP0005058_abnormal_lysosome_morphology2.04593966
42MP0001348_abnormal_lacrimal_gland2.04288104
43MP0004484_altered_response_of2.04146592
44MP0003950_abnormal_plasma_membrane2.01365325
45MP0002972_abnormal_cardiac_muscle1.92786961
46MP0000750_abnormal_muscle_regeneration1.91031720
47MP0005369_muscle_phenotype1.87503809
48MP0005379_endocrine/exocrine_gland_phen1.87439415
49MP0002398_abnormal_bone_marrow1.87116616
50MP0004087_abnormal_muscle_fiber1.86259821
51MP0006082_CNS_inflammation1.84719960
52MP0004947_skin_inflammation1.84605533
53MP0000716_abnormal_immune_system1.84100250
54MP0002876_abnormal_thyroid_physiology1.80284192
55MP0003137_abnormal_impulse_conducting1.78648836
56MP0003763_abnormal_thymus_physiology1.75498971
57MP0002006_tumorigenesis1.75361076
58MP0001853_heart_inflammation1.73216251
59MP0009745_abnormal_behavioral_response1.68772243
60MP0002277_abnormal_respiratory_mucosa1.68571958
61MP0002269_muscular_atrophy1.67566806
62MP0001501_abnormal_sleep_pattern1.67217874
63MP0005330_cardiomyopathy1.66869608
64MP0003191_abnormal_cellular_cholesterol1.66214216
65MP0000427_abnormal_hair_cycle1.61824641
66MP0001845_abnormal_inflammatory_respons1.60275029
67MP0002405_respiratory_system_inflammati1.58452349
68MP0003724_increased_susceptibility_to1.57889006
69MP0003172_abnormal_lysosome_physiology1.55862865
70MP0005464_abnormal_platelet_physiology1.55837449
71MP0004085_abnormal_heartbeat1.54392389
72MP0010155_abnormal_intestine_physiology1.51113757
73MP0002429_abnormal_blood_cell1.49080977
74MP0003045_fibrosis1.48903893
75MP0000747_muscle_weakness1.48388888
76MP0000689_abnormal_spleen_morphology1.47960168
77MP0008469_abnormal_protein_level1.47897661
78MP0002722_abnormal_immune_system1.47846079
79MP0000759_abnormal_skeletal_muscle1.46926658
80MP0002693_abnormal_pancreas_physiology1.44376725
81MP0005266_abnormal_metabolism1.43478602
82MP0004142_abnormal_muscle_tone1.42638989
83MP0003300_gastrointestinal_ulcer1.42480883
84MP0002396_abnormal_hematopoietic_system1.38453186
85MP0001986_abnormal_taste_sensitivity1.36393027
86MP0009333_abnormal_splenocyte_physiolog1.36177244
87MP0001533_abnormal_skeleton_physiology1.33560289
88MP0001968_abnormal_touch/_nociception1.32027114
89MP0001873_stomach_inflammation1.31707285
90MP0002127_abnormal_cardiovascular_syste1.31023188
91MP0000604_amyloidosis1.30426767
92MP0001544_abnormal_cardiovascular_syste1.30299871
93MP0005385_cardiovascular_system_phenoty1.30299871
94MP0005551_abnormal_eye_electrophysiolog1.29739299
95MP0006138_congestive_heart_failure1.28926631
96MP0005386_behavior/neurological_phenoty1.26073052
97MP0004924_abnormal_behavior1.26073052
98MP0002064_seizures1.23095578
99MP0010234_abnormal_vibrissa_follicle1.23049542
100MP0003183_abnormal_peptide_metabolism1.22879906
101MP0004147_increased_porphyrin_level1.22798628
102MP0002272_abnormal_nervous_system1.22204736
103MP0010307_abnormal_tumor_latency1.17112115
104MP0008961_abnormal_basal_metabolism1.16927742
105MP0002108_abnormal_muscle_morphology1.16663305
106MP0000230_abnormal_systemic_arterial1.16491662
107MP0002102_abnormal_ear_morphology1.14586499
108MP0008877_abnormal_DNA_methylation1.13713563
109MP0002009_preneoplasia1.13656587
110MP0003448_altered_tumor_morphology1.12894841
111MP0005397_hematopoietic_system_phenotyp1.12093450
112MP0001545_abnormal_hematopoietic_system1.12093450
113MP0008872_abnormal_physiological_respon1.11802983
114MP0001346_abnormal_lacrimal_gland1.11309920
115MP0004233_abnormal_muscle_weight1.10577343
116MP0010352_gastrointestinal_tract_polyps1.10523442
117MP0000703_abnormal_thymus_morphology1.08169775
118MP0009764_decreased_sensitivity_to1.07483095
119MP0008875_abnormal_xenobiotic_pharmacok1.05435481
120MP0005167_abnormal_blood-brain_barrier1.03009583
121MP0003866_abnormal_defecation1.02688510
122MP0002638_abnormal_pupillary_reflex0.99492057
123MP0009780_abnormal_chondrocyte_physiolo0.98896160
124MP0003635_abnormal_synaptic_transmissio0.97363766
125MP0002067_abnormal_sensory_capabilities0.94666231
126MP0005076_abnormal_cell_differentiation0.94056260
127MP0003186_abnormal_redox_activity0.91705397
128MP0001486_abnormal_startle_reflex0.90054676
129MP0004808_abnormal_hematopoietic_stem0.88586791
130MP0003656_abnormal_erythrocyte_physiolo0.87839316
131MP0002063_abnormal_learning/memory/cond0.87822391
132MP0002736_abnormal_nociception_after0.86839112
133MP0010630_abnormal_cardiac_muscle0.85632096
134MP0000609_abnormal_liver_physiology0.85327136
135MP0000013_abnormal_adipose_tissue0.84973435
136MP0002735_abnormal_chemical_nociception0.84454056
137MP0008260_abnormal_autophagy0.83955665
138MP0010386_abnormal_urinary_bladder0.83825912
139MP0000858_altered_metastatic_potential0.82958872
140MP0000383_abnormal_hair_follicle0.82797676
141MP0002572_abnormal_emotion/affect_behav0.82572709
142MP0005174_abnormal_tail_pigmentation0.81146767
143MP0005423_abnormal_somatic_nervous0.79579473
144MP0005595_abnormal_vascular_smooth0.78892662
145MP0006276_abnormal_autonomic_nervous0.78876000
146MP0000490_abnormal_crypts_of0.78365943
147MP0008057_abnormal_DNA_replication0.77644501
148MP0001881_abnormal_mammary_gland0.76274256
149MP0005503_abnormal_tendon_morphology0.76248469
150MP0005645_abnormal_hypothalamus_physiol0.75234792
151MP0003252_abnormal_bile_duct0.74836569
152MP0002734_abnormal_mechanical_nocicepti0.74218240
153MP0005646_abnormal_pituitary_gland0.73231990
154MP0009763_increased_sensitivity_to0.72924092
155MP0000343_altered_response_to0.72734244
156MP0002139_abnormal_hepatobiliary_system0.72006132
157MP0002019_abnormal_tumor_incidence0.70702180
158MP0005253_abnormal_eye_physiology0.70454803
159MP0003693_abnormal_embryo_hatching0.69313046
160MP0002998_abnormal_bone_remodeling0.68242425
161MP0006036_abnormal_mitochondrial_physio0.67179256
162MP0005187_abnormal_penis_morphology0.67087297
163MP0003646_muscle_fatigue0.66692556
164MP0005670_abnormal_white_adipose0.66690461
165MP0001765_abnormal_ion_homeostasis0.66406704
166MP0001970_abnormal_pain_threshold0.66265773
167MP0003453_abnormal_keratinocyte_physiol0.64900473
168MP0002933_joint_inflammation0.64866748
169MP0004270_analgesia0.64731901
170MP0009384_cardiac_valve_regurgitation0.64052713
171MP0002168_other_aberrant_phenotype0.63062419
172MP0002733_abnormal_thermal_nociception0.62040409
173MP0005584_abnormal_enzyme/coenzyme_acti0.61527348
174MP0001485_abnormal_pinna_reflex0.61193366
175MP0001944_abnormal_pancreas_morphology0.61058400
176MP0000371_diluted_coat_color0.60344515
177MP0004885_abnormal_endolymph0.60258181
178MP0003075_altered_response_to0.60161421
179MP0005448_abnormal_energy_balance0.60056892
180MP0000465_gastrointestinal_hemorrhage0.59476486
181MP0005319_abnormal_enzyme/_coenzyme0.59220708
182MP0000733_abnormal_muscle_development0.59106596
183MP0009643_abnormal_urine_homeostasis0.58686694
184MP0005621_abnormal_cell_physiology0.57896198
185MP0001661_extended_life_span0.57706886
186MP0005535_abnormal_body_temperature0.57675002
187MP0003195_calcinosis0.57574159
188MP0002136_abnormal_kidney_physiology0.57480124
189MP0003879_abnormal_hair_cell0.57073530
190MP0000598_abnormal_liver_morphology0.55796550
191MP0003828_pulmonary_edema0.55316464

Predicted human phenotypes

RankGene SetZ-score
1Type 1 muscle fiber predominance (HP:0003803)4.85612102
2Eczematoid dermatitis (HP:0000976)4.76070411
3Calf muscle hypertrophy (HP:0008981)4.74843256
4Muscle hypertrophy of the lower extremities (HP:0008968)4.65527660
5Bundle branch block (HP:0011710)4.55558774
6Recurrent abscess formation (HP:0002722)4.22992024
7Recurrent bacterial skin infections (HP:0005406)4.21620747
8Abnormality of the calf musculature (HP:0001430)3.95537472
9Increased IgM level (HP:0003496)3.89232531
10Chronic otitis media (HP:0000389)3.87977768
11Sudden death (HP:0001699)3.87441347
12Hyporeflexia of lower limbs (HP:0002600)3.86424819
13Exercise-induced myalgia (HP:0003738)3.76757864
14Abnormality of alanine metabolism (HP:0010916)3.76355352
15Hyperalaninemia (HP:0003348)3.76355352
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.76355352
17Recurrent fungal infections (HP:0002841)3.69924529
18Recurrent viral infections (HP:0004429)3.67138182
19Autoimmune thrombocytopenia (HP:0001973)3.62727440
20Abnormality of macrophages (HP:0004311)3.59569042
21Recurrent gram-negative bacterial infections (HP:0005420)3.57725095
22Elevated erythrocyte sedimentation rate (HP:0003565)3.52780659
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.44787773
24Hyperventilation (HP:0002883)3.44596448
25Atrial fibrillation (HP:0005110)3.43307104
26Myositis (HP:0100614)3.37497759
27EMG: myopathic abnormalities (HP:0003458)3.29263973
28Genetic anticipation (HP:0003743)3.26541659
29Exercise-induced muscle cramps (HP:0003710)3.25941402
30Pancreatic cysts (HP:0001737)3.25122301
31Tetraparesis (HP:0002273)3.21648627
32Muscle fiber splitting (HP:0003555)3.17184198
33Primary atrial arrhythmia (HP:0001692)3.15608569
34Autoimmune hemolytic anemia (HP:0001890)3.15291046
35Mediastinal lymphadenopathy (HP:0100721)3.14035417
36Protruding tongue (HP:0010808)3.03259409
37Febrile seizures (HP:0002373)2.99779791
38Orchitis (HP:0100796)2.99040073
39Supraventricular tachycardia (HP:0004755)2.97095317
40Increased IgE level (HP:0003212)2.95788846
41Syncope (HP:0001279)2.94950226
42Hypergammaglobulinemia (HP:0010702)2.93614312
43Abnormality of the renal cortex (HP:0011035)2.93552025
44Heart block (HP:0012722)2.92179326
45Vacuolated lymphocytes (HP:0001922)2.91992367
46Clumsiness (HP:0002312)2.91316850
47Areflexia of lower limbs (HP:0002522)2.91012323
48Optic neuritis (HP:0100653)2.88645933
49Retrobulbar optic neuritis (HP:0100654)2.88645933
50Abnormality of T cell number (HP:0011839)2.88349934
51Rimmed vacuoles (HP:0003805)2.88102699
52Supraventricular arrhythmia (HP:0005115)2.85814562
53Vasculitis (HP:0002633)2.84041973
54Type II lissencephaly (HP:0007260)2.82694665
55Fatigue (HP:0012378)2.81075722
56Lipoatrophy (HP:0100578)2.80616733
57Subaortic stenosis (HP:0001682)2.77099489
58Abnormality of the left ventricular outflow tract (HP:0011103)2.77099489
59Eosinophilia (HP:0001880)2.77026457
60Gaze-evoked nystagmus (HP:0000640)2.76191343
61Increased cerebral lipofuscin (HP:0011813)2.74842188
62Recurrent skin infections (HP:0001581)2.74776847
63Prolonged QT interval (HP:0001657)2.73988309
64Abnormality of T cell physiology (HP:0011840)2.72737023
65Inability to walk (HP:0002540)2.72076865
66Abnormality of midbrain morphology (HP:0002418)2.70239633
67Molar tooth sign on MRI (HP:0002419)2.70239633
68Progressive cerebellar ataxia (HP:0002073)2.67251923
69Interstitial pulmonary disease (HP:0006530)2.67141278
70Fair hair (HP:0002286)2.65288658
71Increased neuronal autofluorescent lipopigment (HP:0002074)2.64375268
72Abnormality of T cells (HP:0002843)2.61260570
73Chronic obstructive pulmonary disease (HP:0006510)2.60930788
74Obstructive lung disease (HP:0006536)2.60930788
75Abnormal atrioventricular conduction (HP:0005150)2.60452456
76Dysostosis multiplex (HP:0000943)2.60051466
77Ventricular tachycardia (HP:0004756)2.59710462
78Congenital stationary night blindness (HP:0007642)2.58531281
79Pulmonary infiltrates (HP:0002113)2.58394298
80Pancreatic fibrosis (HP:0100732)2.58359836
81Recurrent bronchitis (HP:0002837)2.57013913
82Cerebral hemorrhage (HP:0001342)2.52850915
83Hematochezia (HP:0002573)2.45294367
84Leukocytosis (HP:0001974)2.45127755
85Hyperkalemia (HP:0002153)2.44338949
86Granulocytopenia (HP:0001913)2.44022184
87Myocardial infarction (HP:0001658)2.43776703
88Left ventricular hypertrophy (HP:0001712)2.43454551
89Urticaria (HP:0001025)2.40952048
90Gastrointestinal infarctions (HP:0005244)2.40630781
91Basal ganglia calcification (HP:0002135)2.40592639
92Dysmetric saccades (HP:0000641)2.40347650
93Broad-based gait (HP:0002136)2.40259663
94Urinary glycosaminoglycan excretion (HP:0003541)2.39821910
95Mucopolysacchariduria (HP:0008155)2.39821910
96Nasal polyposis (HP:0100582)2.38778433
97Inflammation of the large intestine (HP:0002037)2.38658526
98Polycythemia (HP:0001901)2.38469575
99Distal arthrogryposis (HP:0005684)2.38093459
100Recurrent cutaneous fungal infections (HP:0011370)2.37517477
101Chronic mucocutaneous candidiasis (HP:0002728)2.37517477
102Asymmetric septal hypertrophy (HP:0001670)2.37428833
103Hypoplastic ischia (HP:0003175)2.36654034
104Neck muscle weakness (HP:0000467)2.36574681
105Arterial thrombosis (HP:0004420)2.35194208
106Nephronophthisis (HP:0000090)2.33451618
107Meningitis (HP:0001287)2.33126919
108Cellulitis (HP:0100658)2.32798942
109Colitis (HP:0002583)2.32120533
110T lymphocytopenia (HP:0005403)2.31855963
111EMG: neuropathic changes (HP:0003445)2.31506316
112Gastrointestinal inflammation (HP:0004386)2.31212482
113Tubular atrophy (HP:0000092)2.30822624
114Gingival bleeding (HP:0000225)2.30312529
115Gingivitis (HP:0000230)2.30297484
116Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.29971397
117Abnormality of eosinophils (HP:0001879)2.26430359
118Cerebellar dysplasia (HP:0007033)2.25826866
119Myopathic facies (HP:0002058)2.24411003
120Abnormal EKG (HP:0003115)2.24053194
121Joint swelling (HP:0001386)2.23959132
122Thrombocytosis (HP:0001894)2.23190620
123Abnormal drinking behavior (HP:0030082)2.20171514
124Polydipsia (HP:0001959)2.20171514
125Generalized hypopigmentation of hair (HP:0011358)2.18893933
126Dilated cardiomyopathy (HP:0001644)2.17866386
127Abnormality of the ischium (HP:0003174)2.16411682
128Stomatitis (HP:0010280)2.16220692
129Muscular dystrophy (HP:0003560)2.16217656
130Agammaglobulinemia (HP:0004432)2.15760210
131Encephalitis (HP:0002383)2.15660882
132Decreased circulating renin level (HP:0003351)2.15268879
133Abnormality of the nasal mucosa (HP:0000433)2.14399159
134Spontaneous hematomas (HP:0007420)2.14077521
135IgG deficiency (HP:0004315)2.12761212
136Progressive inability to walk (HP:0002505)2.11187051
137Abnormality of the renal medulla (HP:0100957)2.10525140
138True hermaphroditism (HP:0010459)2.10298577
139Pelvic girdle muscle weakness (HP:0003749)2.09006021
140Renal cortical cysts (HP:0000803)2.06697077
141Frequent falls (HP:0002359)2.05946930
142Anorexia (HP:0002039)2.05544316
143Ventricular arrhythmia (HP:0004308)2.05376679
144Periodontitis (HP:0000704)2.04912314
145Ventricular fibrillation (HP:0001663)2.04638945
146Myoglobinuria (HP:0002913)2.04104791
147Muscle fiber inclusion bodies (HP:0100299)2.03459443
148Large for gestational age (HP:0001520)2.03042712
149Pheochromocytoma (HP:0002666)2.02678194
150Chest pain (HP:0100749)2.02655224
151Myotonia (HP:0002486)2.02243991
152Abnormality of mucopolysaccharide metabolism (HP:0011020)2.01145044
153Abnormality of polysaccharide metabolism (HP:0011012)2.01145044
154Abnormality of glycosaminoglycan metabolism (HP:0004371)2.01145044
155Generalized muscle weakness (HP:0003324)1.99611914
156Chorioretinal atrophy (HP:0000533)1.97990374
157Exertional dyspnea (HP:0002875)1.97470753
158Pustule (HP:0200039)1.96755557
159Severe muscular hypotonia (HP:0006829)1.94756215
160Focal seizures (HP:0007359)1.94531278
161Abnormality of cells of the lymphoid lineage (HP:0012140)1.93468768
162Absence seizures (HP:0002121)1.93308694
163Hypoplasia of the pons (HP:0012110)1.93119620
164Hypochromic anemia (HP:0001931)1.92618239
165Vertebral compression fractures (HP:0002953)1.92584758
166Dialeptic seizures (HP:0011146)1.91745074
167Chronic sinusitis (HP:0011109)1.91694627
168Neuroendocrine neoplasm (HP:0100634)1.91661939
169Panhypogammaglobulinemia (HP:0003139)1.91473142
170Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89842819
171Absent speech (HP:0001344)1.89324296
172Absent phalangeal crease (HP:0006109)1.88404083
173Atrioventricular block (HP:0001678)1.88187607
174Focal motor seizures (HP:0011153)1.88085333
175Abnormality of potassium homeostasis (HP:0011042)1.87976179
176Nemaline bodies (HP:0003798)1.86384789
177Furrowed tongue (HP:0000221)1.86312201
178Amaurosis fugax (HP:0100576)1.85349239
179Short chin (HP:0000331)1.84846724
180Ulnar deviation of the wrist (HP:0003049)1.84620550
181Facial diplegia (HP:0001349)1.83204717
182Bulbous nose (HP:0000414)1.83095093
183Loss of speech (HP:0002371)1.83034376
184Attenuation of retinal blood vessels (HP:0007843)1.82411343
185Partial agenesis of the corpus callosum (HP:0001338)1.82333436
186Chronic hepatic failure (HP:0100626)1.82086449
187Chronic diarrhea (HP:0002028)1.82072870
188IgM deficiency (HP:0002850)1.82051105
189Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.82000963
190Abnormality of the pons (HP:0007361)1.81817355
191Epistaxis (HP:0000421)1.79330347
192Lymphopenia (HP:0001888)1.78923312
193Abnormality of the hip-girdle musculature (HP:0001445)1.77548425
194Abnormality of the musculature of the pelvis (HP:0001469)1.77548425

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.07254884
2MAP3K144.45730132
3RIPK44.04936155
4TYK23.59735667
5MAP3K133.24735312
6TBK13.13687256
7BMPR1B2.86323212
8JAK32.86029335
9PHKG22.83920234
10PHKG12.83920234
11ADRBK22.82407136
12IKBKB2.45870843
13PINK12.43952931
14TTN2.40512971
15ACVR1B2.27792506
16BLK2.24828385
17DAPK22.18083859
18JAK12.15608246
19MAP4K12.11105855
20IKBKE2.09685864
21AKT31.98794278
22KIT1.92338389
23FLT31.89117352
24IRAK41.88985616
25ZAP701.79906047
26CHUK1.74306196
27TRPM71.70367144
28SCYL21.67762700
29SYK1.65169020
30ERN11.64698064
31MAPKAPK31.64068227
32NME21.60205976
33FGFR41.59752715
34PIK3CA1.57640806
35TAOK31.56546530
36GRK61.53415472
37TXK1.50386758
38PAK31.49000328
39BTK1.45960607
40MAP3K121.43533583
41ARAF1.42923362
42INSRR1.39865686
43MARK11.39609844
44MYLK1.37940380
45GRK11.34288744
46WNK41.33113999
47MAP3K71.30543191
48ADRBK11.30511629
49TEC1.30014855
50RPS6KA41.24947965
51MKNK21.24869992
52PIM21.20290289
53PTK2B1.19592476
54NLK1.18161817
55EPHB11.17730022
56ZAK1.16399529
57MUSK1.15256291
58MAPK131.13929369
59WEE11.13896765
60EIF2AK11.13837673
61DMPK1.12295425
62MAP3K111.08117562
63JAK21.07882910
64EIF2AK31.07641410
65LCK1.07342504
66CSF1R1.06398176
67ITK1.06335545
68FGFR31.05606393
69MAP2K31.05476628
70BMPR21.04966545
71PTK61.04168707
72SGK21.04059379
73TRIB31.03617283
74BRSK21.01769971
75NEK20.98580385
76IRAK30.98279589
77MAPK120.96845951
78NTRK30.95931470
79CSK0.94827291
80TGFBR10.94566495
81MAP3K10.94201384
82EPHA30.92064395
83PIM10.91710120
84PKN10.91221816
85NUAK10.90831377
86CAMKK20.90688206
87MAP3K50.90110445
88CAMK10.88327723
89MAP3K100.87650844
90MAP2K10.84880134
91STK100.82868317
92HIPK20.82828958
93CAMK2A0.82113817
94MAP4K20.81354156
95PRKAA10.79372392
96OXSR10.74727056
97MAP3K40.73624915
98RET0.72811627
99LYN0.72768228
100GRK70.70824442
101CASK0.70350476
102CAMK2D0.69933007
103WNK10.69401815
104PRKCE0.68696704
105HCK0.68455532
106BCR0.67440332
107PAK60.67261712
108CAMK40.66796151
109PASK0.64747012
110CAMKK10.64034704
111KSR20.62990587
112RIPK10.61919534
113WNK30.61260505
114TESK20.61224928
115STK110.60978967
116SGK30.60487852
117MAP2K40.59814619
118NEK90.58987026
119KDR0.58952157
120IRAK10.58866802
121STK240.57864111
122MAPK110.57159090
123STK390.57035889
124STK38L0.55998679
125SGK4940.54650100
126SGK2230.54650100
127SIK20.53986602
128MAPKAPK20.53666755
129PRKG10.52285724
130FGR0.52215494
131LRRK20.51571584
132MARK30.51269315
133RPS6KA60.49910048
134STK380.49800202
135PRKCD0.49149838
136MELK0.48521361
137NME10.47927353
138DYRK30.46054568
139MAP3K90.45935965
140ROCK10.45671110
141CAMK2B0.45582760
142TIE10.45275867
143PIK3CG0.44455635
144MAP3K30.43340152
145PRKCQ0.42920957
146MOS0.42244432
147MAP3K80.42066684
148ABL20.41566390
149PRKACA0.40758055
150PRKAA20.40521290
151TNIK0.40431506
152MAPK70.40084668
153MAP2K60.39080329
154CAMK2G0.38266124
155PDK10.38246790
156MST40.35630848
157RPS6KA30.35604086
158FES0.34526032
159PNCK0.34329410
160PRKCG0.34296758
161RPS6KA50.33327847
162EGFR0.33160248
163MAPKAPK50.31451376
164CDC42BPA0.31254980
165SGK10.31253142
166PDGFRB0.30419373
167EIF2AK20.29913714
168MAPK40.28881938
169RAF10.27794338
170PRKCH0.27377497
171MKNK10.27092874
172RPS6KA10.25930567
173OBSCN0.25732297
174TLK10.25354518

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.06894217
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.92029788
3Nitrogen metabolism_Homo sapiens_hsa009102.90983773
4Dilated cardiomyopathy_Homo sapiens_hsa054142.80336717
5Allograft rejection_Homo sapiens_hsa053302.76276203
6Leishmaniasis_Homo sapiens_hsa051402.75379524
7Cardiac muscle contraction_Homo sapiens_hsa042602.57012072
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.54390262
9Graft-versus-host disease_Homo sapiens_hsa053322.52391486
10Type I diabetes mellitus_Homo sapiens_hsa049402.41735804
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.41020178
12Measles_Homo sapiens_hsa051622.38976303
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.36930029
14Antigen processing and presentation_Homo sapiens_hsa046122.26823118
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.20148653
16Linoleic acid metabolism_Homo sapiens_hsa005912.18597746
17Legionellosis_Homo sapiens_hsa051342.18133089
18Osteoclast differentiation_Homo sapiens_hsa043802.16017413
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.14415491
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.03363758
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.97535129
22Circadian rhythm_Homo sapiens_hsa047101.97049467
23Tryptophan metabolism_Homo sapiens_hsa003801.93348280
24Calcium signaling pathway_Homo sapiens_hsa040201.93224348
25TNF signaling pathway_Homo sapiens_hsa046681.92301550
26Phototransduction_Homo sapiens_hsa047441.89700542
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.88859433
28ABC transporters_Homo sapiens_hsa020101.87251814
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.85958672
30Primary immunodeficiency_Homo sapiens_hsa053401.84819008
31B cell receptor signaling pathway_Homo sapiens_hsa046621.82954441
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.77325555
33Circadian entrainment_Homo sapiens_hsa047131.77033310
34Butanoate metabolism_Homo sapiens_hsa006501.76902947
35Tuberculosis_Homo sapiens_hsa051521.75437830
36Oxytocin signaling pathway_Homo sapiens_hsa049211.74513666
37Autoimmune thyroid disease_Homo sapiens_hsa053201.72943159
38Influenza A_Homo sapiens_hsa051641.71907215
39Vascular smooth muscle contraction_Homo sapiens_hsa042701.71065540
40Herpes simplex infection_Homo sapiens_hsa051681.69736157
41Morphine addiction_Homo sapiens_hsa050321.67937024
42Insulin secretion_Homo sapiens_hsa049111.66947323
43Toxoplasmosis_Homo sapiens_hsa051451.61494726
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.59621910
45Apoptosis_Homo sapiens_hsa042101.57949754
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52607012
47Nicotine addiction_Homo sapiens_hsa050331.49805562
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.48933299
49Lysosome_Homo sapiens_hsa041421.48003878
50Rheumatoid arthritis_Homo sapiens_hsa053231.46718419
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45661662
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.43842291
53Olfactory transduction_Homo sapiens_hsa047401.41290452
54Shigellosis_Homo sapiens_hsa051311.41057733
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39088313
56T cell receptor signaling pathway_Homo sapiens_hsa046601.38803158
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37931637
58Chemokine signaling pathway_Homo sapiens_hsa040621.35216856
59Dorso-ventral axis formation_Homo sapiens_hsa043201.34512248
60Regulation of autophagy_Homo sapiens_hsa041401.30890639
61Pertussis_Homo sapiens_hsa051331.30308241
62Serotonergic synapse_Homo sapiens_hsa047261.27941376
63Proteasome_Homo sapiens_hsa030501.27610051
64Staphylococcus aureus infection_Homo sapiens_hsa051501.27479901
65Glutamatergic synapse_Homo sapiens_hsa047241.27102340
66cGMP-PKG signaling pathway_Homo sapiens_hsa040221.26439041
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21446364
68Salivary secretion_Homo sapiens_hsa049701.19688672
69Primary bile acid biosynthesis_Homo sapiens_hsa001201.18924519
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17683821
71Prolactin signaling pathway_Homo sapiens_hsa049171.16673196
72Taste transduction_Homo sapiens_hsa047421.16670752
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16168622
74Ether lipid metabolism_Homo sapiens_hsa005651.15691417
75GABAergic synapse_Homo sapiens_hsa047271.15045403
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14333268
77Cholinergic synapse_Homo sapiens_hsa047251.13862048
78Epstein-Barr virus infection_Homo sapiens_hsa051691.13612403
79African trypanosomiasis_Homo sapiens_hsa051431.13029162
80Gastric acid secretion_Homo sapiens_hsa049711.12411686
81Renin secretion_Homo sapiens_hsa049241.07547949
82Long-term depression_Homo sapiens_hsa047301.07497110
83Ovarian steroidogenesis_Homo sapiens_hsa049131.06205019
84cAMP signaling pathway_Homo sapiens_hsa040241.04227895
85p53 signaling pathway_Homo sapiens_hsa041151.03329552
86Hepatitis B_Homo sapiens_hsa051611.03269268
87Acute myeloid leukemia_Homo sapiens_hsa052211.02983375
88SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02171573
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00001741
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99550084
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97613147
92Hepatitis C_Homo sapiens_hsa051600.97577404
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97279537
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96537729
95Hematopoietic cell lineage_Homo sapiens_hsa046400.92484739
96Insulin resistance_Homo sapiens_hsa049310.92380533
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92055837
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91603100
99Amphetamine addiction_Homo sapiens_hsa050310.91107869
100Phagosome_Homo sapiens_hsa041450.90345601
101Viral myocarditis_Homo sapiens_hsa054160.89492882
102Dopaminergic synapse_Homo sapiens_hsa047280.89268902
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.89023219
104Caffeine metabolism_Homo sapiens_hsa002320.88489230
105Asthma_Homo sapiens_hsa053100.85968710
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85926924
107Salmonella infection_Homo sapiens_hsa051320.84133390
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.83906447
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82187770
110Malaria_Homo sapiens_hsa051440.81186087
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79793669
112Cocaine addiction_Homo sapiens_hsa050300.79710238
113Selenocompound metabolism_Homo sapiens_hsa004500.78910402
114Type II diabetes mellitus_Homo sapiens_hsa049300.78669185
115Lysine degradation_Homo sapiens_hsa003100.78605220
116Pancreatic secretion_Homo sapiens_hsa049720.77308599
117Glucagon signaling pathway_Homo sapiens_hsa049220.76137195
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75415745
119mTOR signaling pathway_Homo sapiens_hsa041500.75266520
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74194260
121Collecting duct acid secretion_Homo sapiens_hsa049660.71196807
122Histidine metabolism_Homo sapiens_hsa003400.70582058
123beta-Alanine metabolism_Homo sapiens_hsa004100.70005619
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69661296
125Viral carcinogenesis_Homo sapiens_hsa052030.66932130
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66585739
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.65050673
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64463093
129Pentose phosphate pathway_Homo sapiens_hsa000300.64278108
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64136367
131VEGF signaling pathway_Homo sapiens_hsa043700.63851151
132Folate biosynthesis_Homo sapiens_hsa007900.63668317
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59969715
134Propanoate metabolism_Homo sapiens_hsa006400.59163831
135Bile secretion_Homo sapiens_hsa049760.55913065
136Peroxisome_Homo sapiens_hsa041460.55467113
137Arachidonic acid metabolism_Homo sapiens_hsa005900.53875388
138Protein export_Homo sapiens_hsa030600.53456670
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53312188
140Other glycan degradation_Homo sapiens_hsa005110.52882437
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52810134
142Glycerolipid metabolism_Homo sapiens_hsa005610.51257765
143Thyroid cancer_Homo sapiens_hsa052160.50383067
144Leukocyte transendothelial migration_Homo sapiens_hsa046700.50203540
145FoxO signaling pathway_Homo sapiens_hsa040680.50154071
146Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49154350
147Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49014091
148AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47484282
149Vibrio cholerae infection_Homo sapiens_hsa051100.46509533
150Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46061395
151Chronic myeloid leukemia_Homo sapiens_hsa052200.45261936
152GnRH signaling pathway_Homo sapiens_hsa049120.42013965
153Fatty acid degradation_Homo sapiens_hsa000710.41836094
154Platelet activation_Homo sapiens_hsa046110.41485442
155Fatty acid biosynthesis_Homo sapiens_hsa000610.41331859
156Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41159401
157Pancreatic cancer_Homo sapiens_hsa052120.41150124
158Long-term potentiation_Homo sapiens_hsa047200.40841591
159Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39695322
160HIF-1 signaling pathway_Homo sapiens_hsa040660.38193625
161Glycerophospholipid metabolism_Homo sapiens_hsa005640.38155199
162Insulin signaling pathway_Homo sapiens_hsa049100.37967606
163Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37750724
164Arginine and proline metabolism_Homo sapiens_hsa003300.37258639
165Melanoma_Homo sapiens_hsa052180.36587928
166Fructose and mannose metabolism_Homo sapiens_hsa000510.36001408
167Chemical carcinogenesis_Homo sapiens_hsa052040.35734284
168AMPK signaling pathway_Homo sapiens_hsa041520.35628356
169Ras signaling pathway_Homo sapiens_hsa040140.34783987
170Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34252275
171Retinol metabolism_Homo sapiens_hsa008300.33161622
172Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33121984
173Sphingolipid signaling pathway_Homo sapiens_hsa040710.33064840
174Inositol phosphate metabolism_Homo sapiens_hsa005620.32978244
175Small cell lung cancer_Homo sapiens_hsa052220.31722161
176Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31046000
177PPAR signaling pathway_Homo sapiens_hsa033200.30595531
178Glycosaminoglycan degradation_Homo sapiens_hsa005310.30526768
179Sulfur metabolism_Homo sapiens_hsa009200.30488034
180Endocytosis_Homo sapiens_hsa041440.30418485
181Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30007291
182Choline metabolism in cancer_Homo sapiens_hsa052310.28218368
183DNA replication_Homo sapiens_hsa030300.27223411
184MAPK signaling pathway_Homo sapiens_hsa040100.26139494

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