RNF121

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Several alternatively spliced transcript variants have been noted for this gene, however, not all are likely to encode viable protein products. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)7.56534901
2negative regulation of macroautophagy (GO:0016242)5.38981307
3detection of molecule of bacterial origin (GO:0032490)5.12581368
4exogenous drug catabolic process (GO:0042738)4.90845804
5drug catabolic process (GO:0042737)4.71091263
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.55683122
7viral mRNA export from host cell nucleus (GO:0046784)4.52137651
8behavioral response to nicotine (GO:0035095)4.45848998
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.34335910
10oxaloacetate metabolic process (GO:0006107)4.19708640
11RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.08510899
12tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.08510899
13L-serine metabolic process (GO:0006563)4.03555694
14NADH metabolic process (GO:0006734)3.89733839
15cysteine metabolic process (GO:0006534)3.84729239
16high-density lipoprotein particle remodeling (GO:0034375)3.83806773
17response to pheromone (GO:0019236)3.78495740
18kynurenine metabolic process (GO:0070189)3.78394887
19indole-containing compound catabolic process (GO:0042436)3.75894724
20indolalkylamine catabolic process (GO:0046218)3.75894724
21tryptophan catabolic process (GO:0006569)3.75894724
22ribosomal small subunit biogenesis (GO:0042274)3.73397590
23detection of external biotic stimulus (GO:0098581)3.71093415
24maturation of SSU-rRNA (GO:0030490)3.70956834
25cellular anion homeostasis (GO:0030002)3.69451853
26trivalent inorganic anion homeostasis (GO:0072506)3.65092786
27phosphate ion homeostasis (GO:0055062)3.65092786
28lysine metabolic process (GO:0006553)3.60599907
29lysine catabolic process (GO:0006554)3.60599907
30opioid receptor signaling pathway (GO:0038003)3.54507910
31negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.52450423
32ribosome biogenesis (GO:0042254)3.52175947
33aromatic amino acid family catabolic process (GO:0009074)3.51018632
34mitochondrial RNA metabolic process (GO:0000959)3.49026352
35pteridine-containing compound biosynthetic process (GO:0042559)3.48467479
36positive regulation of glycolytic process (GO:0045821)3.46651845
37chaperone-mediated protein transport (GO:0072321)3.45073957
38reverse cholesterol transport (GO:0043691)3.40603379
39folic acid-containing compound biosynthetic process (GO:0009396)3.38889846
40positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.37291017
41protein maturation by protein folding (GO:0022417)3.37109664
42phospholipid efflux (GO:0033700)3.36850052
43pseudouridine synthesis (GO:0001522)3.32406802
44dicarboxylic acid biosynthetic process (GO:0043650)3.28737804
45sulfur amino acid catabolic process (GO:0000098)3.28670843
46serine family amino acid biosynthetic process (GO:0009070)3.27782992
47negative regulation of fibrinolysis (GO:0051918)3.26519598
48erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.26277512
49L-phenylalanine metabolic process (GO:0006558)3.26277512
50regulation of mitochondrial translation (GO:0070129)3.25437165
51regulation of cholesterol esterification (GO:0010872)3.24253417
52tryptophan metabolic process (GO:0006568)3.23268720
53folic acid transport (GO:0015884)3.23178386
54urea metabolic process (GO:0019627)3.21307457
55urea cycle (GO:0000050)3.21307457
56ribonucleoprotein complex biogenesis (GO:0022613)3.19566205
57auditory receptor cell stereocilium organization (GO:0060088)3.17175643
58negative regulation of meiosis (GO:0045835)3.15634369
59proline biosynthetic process (GO:0006561)3.15100136
60L-phenylalanine catabolic process (GO:0006559)3.12696957
61erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.12696957
62succinate metabolic process (GO:0006105)3.12595070
63alpha-linolenic acid metabolic process (GO:0036109)3.12501430
64positive regulation of synapse maturation (GO:0090129)3.10827037
65fructose metabolic process (GO:0006000)3.10649262
66detection of biotic stimulus (GO:0009595)3.09784480
67regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.06781160
68GDP-mannose metabolic process (GO:0019673)3.05353884
69coenzyme catabolic process (GO:0009109)3.04455459
70sulfate transmembrane transport (GO:1902358)3.03602319
71regulation of triglyceride catabolic process (GO:0010896)3.01683892
72tricarboxylic acid cycle (GO:0006099)3.01477615
73arginine metabolic process (GO:0006525)3.01289970
74post-embryonic morphogenesis (GO:0009886)3.01078069
75negative regulation of cholesterol transport (GO:0032375)2.99713590
76negative regulation of sterol transport (GO:0032372)2.99713590
77peptidyl-arginine omega-N-methylation (GO:0035247)2.99520818
78regulation of translation in response to stress (GO:0043555)2.99267970
79cellular glucuronidation (GO:0052695)2.98535740
80NAD metabolic process (GO:0019674)2.97343120
81positive regulation of neurotransmitter secretion (GO:0001956)2.95971320
82regulation of cholesterol homeostasis (GO:2000188)2.94924638
83intestinal cholesterol absorption (GO:0030299)2.94406159
84nucleotide-sugar biosynthetic process (GO:0009226)2.90502588
85plasma lipoprotein particle remodeling (GO:0034369)2.89680256
86protein-lipid complex remodeling (GO:0034368)2.89680256
87macromolecular complex remodeling (GO:0034367)2.89680256
88histone arginine methylation (GO:0034969)2.87648976
89regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.87418791
90regulation of protein activation cascade (GO:2000257)2.86728036
91protein-cofactor linkage (GO:0018065)2.85685400
92maintenance of gastrointestinal epithelium (GO:0030277)2.84020137
93cholesterol efflux (GO:0033344)2.83669446
94homocysteine metabolic process (GO:0050667)2.82244021
95sphingosine metabolic process (GO:0006670)2.81766161
96tRNA processing (GO:0008033)2.80809205
97positive regulation of neurotransmitter transport (GO:0051590)2.79729311
98regulation of bile acid biosynthetic process (GO:0070857)2.79411098
99negative regulation of fatty acid biosynthetic process (GO:0045717)2.79364561
100plasma lipoprotein particle clearance (GO:0034381)2.78457870
101vocalization behavior (GO:0071625)2.76947575
102protein localization to microtubule (GO:0035372)2.76560825
103microtubule severing (GO:0051013)2.75989476
104regulation of translational fidelity (GO:0006450)2.75096431
105tRNA metabolic process (GO:0006399)2.74784949
106COPI coating of Golgi vesicle (GO:0048205)2.73444544
107Golgi transport vesicle coating (GO:0048200)2.73444544
108arginine catabolic process (GO:0006527)2.72555226
109alpha-amino acid catabolic process (GO:1901606)2.72040285
110nitrogen cycle metabolic process (GO:0071941)2.71086745
111cellular component biogenesis (GO:0044085)2.70705878
112aspartate family amino acid catabolic process (GO:0009068)2.69599642
113tRNA aminoacylation for protein translation (GO:0006418)2.67861297
114negative regulation of fatty acid metabolic process (GO:0045922)2.67761549
115L-alpha-amino acid transmembrane transport (GO:1902475)2.67748397
116nucleoside transmembrane transport (GO:1901642)2.67401302
117prostate gland growth (GO:0060736)2.67060938
118folic acid metabolic process (GO:0046655)2.66894560
119regulation of complement activation (GO:0030449)2.66046494
120hexose biosynthetic process (GO:0019319)2.65232655
121gluconeogenesis (GO:0006094)2.65216666
122serine family amino acid catabolic process (GO:0009071)2.64621304
1232-oxoglutarate metabolic process (GO:0006103)2.64173642
124L-ascorbic acid metabolic process (GO:0019852)2.64071362
125microtubule nucleation (GO:0007020)2.63908130
126regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.63659098
127amino-acid betaine metabolic process (GO:0006577)2.62990502
128rRNA processing (GO:0006364)2.62693932
129regulation of fibrinolysis (GO:0051917)2.61964809
130lateral ventricle development (GO:0021670)2.61395818
131cellular modified amino acid catabolic process (GO:0042219)2.61341215
132maturation of 5.8S rRNA (GO:0000460)2.60513067
133fat-soluble vitamin catabolic process (GO:0042363)2.59584894
134vitamin catabolic process (GO:0009111)2.59584894
135regulation of plasminogen activation (GO:0010755)2.59395395
136zinc ion transmembrane transport (GO:0071577)2.59283568
137amino acid activation (GO:0043038)2.59024592
138tRNA aminoacylation (GO:0043039)2.59024592
139bicarbonate transport (GO:0015701)2.58993915
140alanine transport (GO:0032328)2.58520861
141establishment of protein localization to mitochondrial membrane (GO:0090151)2.58227205
142tRNA methylation (GO:0030488)2.57802593
143DNA strand elongation involved in DNA replication (GO:0006271)2.55977576
144negative regulation of response to nutrient levels (GO:0032108)2.55645647
145negative regulation of response to extracellular stimulus (GO:0032105)2.55645647
146regulation of MHC class I biosynthetic process (GO:0045343)2.55143419
147activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.54101155
148serine family amino acid metabolic process (GO:0009069)2.53221582
149ncRNA processing (GO:0034470)2.49995901
150DNA strand elongation (GO:0022616)2.49631345
151pteridine-containing compound metabolic process (GO:0042558)2.46079933
152DNA strand renaturation (GO:0000733)2.44826261
153tetrahydrofolate metabolic process (GO:0046653)2.44714063
154rRNA metabolic process (GO:0016072)2.43391618
155negative regulation of macrophage differentiation (GO:0045650)2.42571152
156maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.42035855
157tRNA modification (GO:0006400)2.39327577
158protein retention in ER lumen (GO:0006621)2.37760600
159nonribosomal peptide biosynthetic process (GO:0019184)2.34866782
160basic amino acid transport (GO:0015802)2.34360323
161folic acid-containing compound metabolic process (GO:0006760)2.33913087
162rRNA modification (GO:0000154)2.32587342
1637-methylguanosine mRNA capping (GO:0006370)2.32314960
164regulation of apoptotic process involved in morphogenesis (GO:1902337)2.31331413
165mesenchymal cell differentiation involved in renal system development (GO:2001012)2.29829696
166mesenchymal cell differentiation involved in kidney development (GO:0072161)2.29829696
167rRNA methylation (GO:0031167)2.29584652
168nucleotide transmembrane transport (GO:1901679)2.28873197
169nucleoside transport (GO:0015858)2.28597202
170transcription from mitochondrial promoter (GO:0006390)2.28103387
171peptidyl-arginine N-methylation (GO:0035246)2.26370781
172peptidyl-arginine methylation (GO:0018216)2.26370781
173paraxial mesoderm development (GO:0048339)2.25684656
174L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.25243040
175rRNA transcription (GO:0009303)2.24101805
176heterochromatin organization (GO:0070828)2.23876173
177ribosomal large subunit biogenesis (GO:0042273)2.23288961
178nucleobase-containing small molecule interconversion (GO:0015949)2.22816522
179sulfur amino acid biosynthetic process (GO:0000097)2.22610228
180ncRNA metabolic process (GO:0034660)2.22021530
181isoprenoid biosynthetic process (GO:0008299)2.21416561
182amyloid precursor protein catabolic process (GO:0042987)2.20735294
1837-methylguanosine RNA capping (GO:0009452)2.20338626
184RNA capping (GO:0036260)2.20338626
185cytokinetic process (GO:0032506)2.19968418
186protoporphyrinogen IX biosynthetic process (GO:0006782)2.18306501
187galactose catabolic process (GO:0019388)2.18010229
188RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.17089985
189water-soluble vitamin biosynthetic process (GO:0042364)2.16911490
190proteasome assembly (GO:0043248)2.16462620
191mitotic chromosome condensation (GO:0007076)2.16110512
192daunorubicin metabolic process (GO:0044597)12.0638423
193polyketide metabolic process (GO:0030638)12.0638423
194doxorubicin metabolic process (GO:0044598)12.0638423

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.28849096
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.14853554
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.98713791
4* RXR_22158963_ChIP-Seq_LIVER_Mouse4.92890868
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.75165460
6E2F7_22180533_ChIP-Seq_HELA_Human4.16883223
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.84440222
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.54844173
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.41069754
10EGR1_23403033_ChIP-Seq_LIVER_Mouse3.40650074
11RXR_22108803_ChIP-Seq_LS180_Human3.37680278
12MYC_18555785_ChIP-Seq_MESCs_Mouse3.19523071
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.05049655
14* GABP_17652178_ChIP-ChIP_JURKAT_Human2.98705547
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.97118079
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.85011493
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.79852237
18* ETS1_20019798_ChIP-Seq_JURKAT_Human2.72987827
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.67969629
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.62296044
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.62034792
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.41596748
23* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.40764380
24RARG_19884340_ChIP-ChIP_MEFs_Mouse2.34718995
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33119367
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31021229
27* EST1_17652178_ChIP-ChIP_JURKAT_Human2.29911815
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.23488537
29GABP_19822575_ChIP-Seq_HepG2_Human2.18392303
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17914964
31* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.15287106
32SRF_21415370_ChIP-Seq_HL-1_Mouse2.13976605
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06875052
34E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06387979
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97010285
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95549426
37XRN2_22483619_ChIP-Seq_HELA_Human1.90721186
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.90518063
39* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90074115
40VDR_22108803_ChIP-Seq_LS180_Human1.86227900
41DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.84291142
42TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.82207449
43CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.79050926
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77905504
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.71331123
46ELK4_26923725_Chip-Seq_MESODERM_Mouse1.67726439
47* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67523782
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66970944
49* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66445098
50* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65116335
51TCF4_22108803_ChIP-Seq_LS180_Human1.64856077
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63873056
53* KDM5A_27292631_Chip-Seq_BREAST_Human1.61825502
54CLOCK_20551151_ChIP-Seq_293T_Human1.60228951
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59515574
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59201151
57DCP1A_22483619_ChIP-Seq_HELA_Human1.59059466
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58123146
59TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.55860180
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.51218709
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.46572151
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.45507566
63DROSHA_22980978_ChIP-Seq_HELA_Human1.40744481
64SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.39857303
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.38960207
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.38843828
67TTF2_22483619_ChIP-Seq_HELA_Human1.37495343
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34113951
69CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34086347
70SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.34020870
71FOXM1_23109430_ChIP-Seq_U2OS_Human1.33861243
72ELK1_19687146_ChIP-ChIP_HELA_Human1.33302738
73* FOXP3_21729870_ChIP-Seq_TREG_Human1.32317208
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32253051
75* HNF4A_19822575_ChIP-Seq_HepG2_Human1.31883607
76CTCF_18555785_ChIP-Seq_MESCs_Mouse1.31501038
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30462053
78BCAT_22108803_ChIP-Seq_LS180_Human1.29578932
79REST_18959480_ChIP-ChIP_MESCs_Mouse1.29215205
80TBX5_21415370_ChIP-Seq_HL-1_Mouse1.29081609
81REST_21632747_ChIP-Seq_MESCs_Mouse1.28068668
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27510708
83TET1_21451524_ChIP-Seq_MESCs_Mouse1.26600659
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.26467557
85ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.25791124
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.25432712
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.25319522
88GBX2_23144817_ChIP-Seq_PC3_Human1.24917816
89SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.24810881
90* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24498886
91AR_21909140_ChIP-Seq_LNCAP_Human1.24452563
92STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23983768
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.23734192
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22996861
95AR_25329375_ChIP-Seq_VCAP_Human1.22313519
96SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21603217
97NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20567671
98HTT_18923047_ChIP-ChIP_STHdh_Human1.20269125
99RACK7_27058665_Chip-Seq_MCF-7_Human1.20076473
100* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20057740
101NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19890740
102* GATA4_25053715_ChIP-Seq_YYC3_Human1.19804525
103SOX17_20123909_ChIP-Seq_XEN_Mouse1.19547174
104* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18850338
105DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18052443
106STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.17199569
107FOXP1_21924763_ChIP-Seq_HESCs_Human1.12938584
108ZNF263_19887448_ChIP-Seq_K562_Human1.11796146
109PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11644359
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11469102
111ATF3_27146783_Chip-Seq_COLON_Human1.11126389
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06022048
113* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05304767
114ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05212950
115TRIM28_21343339_ChIP-Seq_HEK293_Human1.05004716
116ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02965528
117ESR1_21235772_ChIP-Seq_MCF-7_Human1.02802493
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02633196
119FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01827395
120VDR_23849224_ChIP-Seq_CD4+_Human1.01535788
121PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01286554
122* TP53_22573176_ChIP-Seq_HFKS_Human1.01016977
123CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00915230
124ELK3_25401928_ChIP-Seq_HUVEC_Human1.00328492
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00323568
126POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00145371
127RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99549137
128SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99423189
129THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98521969
130FOXA2_19822575_ChIP-Seq_HepG2_Human0.96735830
131ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96617432
132CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96246726
133HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96217494
134KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96123901
135SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95989848
136TFEB_21752829_ChIP-Seq_HELA_Human0.95979860
137CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95816457
138* E2F4_17652178_ChIP-ChIP_JURKAT_Human0.95745865
139CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95691537
140PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95539088
141P300_19829295_ChIP-Seq_ESCs_Human0.95285234
142PIAS1_25552417_ChIP-Seq_VCAP_Human0.93042903
143TP53_18474530_ChIP-ChIP_U2OS_Human0.92680967
144SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92671094
145KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92322982
146EZH2_27294783_Chip-Seq_NPCs_Mouse0.91542500
147PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89639846
148CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89628499
149SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89417555
150SMAD4_21799915_ChIP-Seq_A2780_Human0.86645276
151TCF4_18268006_ChIP-ChIP_LS174T_Human0.86416875
152NANOG_16518401_ChIP-PET_MESCs_Mouse0.83812524
153JARID2_20075857_ChIP-Seq_MESCs_Mouse0.83550090
154RUNX2_22187159_ChIP-Seq_PCA_Human0.83005706
155SMAD3_21741376_ChIP-Seq_HESCs_Human0.81982592
156P53_22387025_ChIP-Seq_ESCs_Mouse0.81009507
157SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.80924271
158EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.79808744
159MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.79634847
160RUNX1_27457419_Chip-Seq_LIVER_Mouse0.77799630
161TAF2_19829295_ChIP-Seq_ESCs_Human0.76957719
162SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.76811051
163RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76544051
164SOX2_21211035_ChIP-Seq_LN229_Gbm0.76352361
165JUN_21703547_ChIP-Seq_K562_Human0.76215661
166RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.76189837
167TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75994334
168TP53_20018659_ChIP-ChIP_R1E_Mouse0.75690959
169SMAD4_21741376_ChIP-Seq_HESCs_Human0.75628088
170SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.74792258
171AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.74256973
172MYC_19829295_ChIP-Seq_ESCs_Human0.74107928
173NCOR_22424771_ChIP-Seq_293T_Human0.73112769
174SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.72420430
175STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.71513756
176RNF2_18974828_ChIP-Seq_MESCs_Mouse0.71359520
177EZH2_18974828_ChIP-Seq_MESCs_Mouse0.71359520
178TP53_22127205_ChIP-Seq_IMR90_Human0.71271980
179FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71207491
180BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70894267
181SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69583909
182RXRA_24833708_ChIP-Seq_LIVER_Mouse0.68729103

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.30177580
2MP0008004_abnormal_stomach_pH4.33247334
3MP0002139_abnormal_hepatobiliary_system4.31403320
4MP0010030_abnormal_orbit_morphology3.96978374
5MP0002254_reproductive_system_inflammat3.83999785
6MP0005085_abnormal_gallbladder_physiolo3.81685534
7MP0005365_abnormal_bile_salt3.67501256
8MP0003941_abnormal_skin_development3.61641406
9MP0003705_abnormal_hypodermis_morpholog3.50637886
10MP0005377_hearing/vestibular/ear_phenot3.21743439
11MP0003878_abnormal_ear_physiology3.21743439
12MP0010329_abnormal_lipoprotein_level3.20691382
13MP0005257_abnormal_intraocular_pressure2.97095606
14MP0009697_abnormal_copulation2.80326742
15MP0000566_synostosis2.74080347
16MP0003646_muscle_fatigue2.63227542
17MP0003693_abnormal_embryo_hatching2.61325414
18MP0003879_abnormal_hair_cell2.59170084
19MP0003191_abnormal_cellular_cholesterol2.48318133
20MP0005408_hypopigmentation2.45537212
21MP0003252_abnormal_bile_duct2.34873758
22MP0003890_abnormal_embryonic-extraembry2.34599692
23MP0001346_abnormal_lacrimal_gland2.30570062
24MP0005248_abnormal_Harderian_gland2.28452609
25MP0003950_abnormal_plasma_membrane2.26172506
26MP0009840_abnormal_foam_cell2.22082106
27MP0002796_impaired_skin_barrier2.09176958
28MP0004957_abnormal_blastocyst_morpholog2.04738395
29MP0003111_abnormal_nucleus_morphology1.99952354
30MP0008058_abnormal_DNA_repair1.98517208
31MP0008875_abnormal_xenobiotic_pharmacok1.91736937
32MP0005058_abnormal_lysosome_morphology1.87156421
33MP0001881_abnormal_mammary_gland1.85162487
34MP0001666_abnormal_nutrient_absorption1.82629987
35MP0008438_abnormal_cutaneous_collagen1.82119630
36MP0005670_abnormal_white_adipose1.80275944
37MP0003806_abnormal_nucleotide_metabolis1.80085512
38MP0009379_abnormal_foot_pigmentation1.79715796
39MP0005645_abnormal_hypothalamus_physiol1.71661357
40MP0003942_abnormal_urinary_system1.70853370
41MP0008932_abnormal_embryonic_tissue1.69333750
42MP0002697_abnormal_eye_size1.67721153
43MP0003186_abnormal_redox_activity1.66505740
44MP0005083_abnormal_biliary_tract1.60760591
45MP0002138_abnormal_hepatobiliary_system1.60012632
46MP0005332_abnormal_amino_acid1.59252265
47MP0000678_abnormal_parathyroid_gland1.59136318
48MP0002938_white_spotting1.57981920
49MP0000003_abnormal_adipose_tissue1.56631672
50MP0001293_anophthalmia1.53173904
51MP0001764_abnormal_homeostasis1.50930206
52MP0003718_maternal_effect1.50452722
53MP0009384_cardiac_valve_regurgitation1.48138115
54MP0004019_abnormal_vitamin_homeostasis1.43646836
55MP0001542_abnormal_bone_strength1.42404966
56MP0003566_abnormal_cell_adhesion1.42160972
57MP0000609_abnormal_liver_physiology1.40592819
58MP0010234_abnormal_vibrissa_follicle1.38194304
59MP0001730_embryonic_growth_arrest1.37860203
60MP0005423_abnormal_somatic_nervous1.36724487
61MP0005451_abnormal_body_composition1.34849188
62MP0000749_muscle_degeneration1.33813535
63MP0004133_heterotaxia1.32043313
64MP0004233_abnormal_muscle_weight1.31435705
65MP0010386_abnormal_urinary_bladder1.30671152
66MP0002132_abnormal_respiratory_system1.29554980
67MP0000750_abnormal_muscle_regeneration1.26490881
68MP0000427_abnormal_hair_cycle1.25369968
69MP0010094_abnormal_chromosome_stability1.24942663
70MP0005197_abnormal_uvea_morphology1.19131570
71MP0000534_abnormal_ureter_morphology1.17469039
72MP0001348_abnormal_lacrimal_gland1.17227023
73MP0001664_abnormal_digestion1.15193205
74MP0005275_abnormal_skin_tensile1.12743185
75MP0002118_abnormal_lipid_homeostasis1.12533050
76MP0002084_abnormal_developmental_patter1.10758303
77MP0000013_abnormal_adipose_tissue1.10300404
78MP0000358_abnormal_cell_content/1.10115900
79MP0004858_abnormal_nervous_system1.09860417
80MP0003183_abnormal_peptide_metabolism1.08733043
81MP0005501_abnormal_skin_physiology1.06386029
82MP0002085_abnormal_embryonic_tissue1.06077716
83MP0002837_dystrophic_cardiac_calcinosis1.05218366
84MP0003077_abnormal_cell_cycle1.04859172
85MP0001529_abnormal_vocalization1.03388770
86MP0002876_abnormal_thyroid_physiology1.03296523
87MP0003279_aneurysm1.03122049
88MP0003937_abnormal_limbs/digits/tail_de1.02693586
89MP0002638_abnormal_pupillary_reflex1.02346207
90MP0000627_abnormal_mammary_gland1.02008742
91MP0003283_abnormal_digestive_organ1.01838928
92MP0004859_abnormal_synaptic_plasticity1.00987205
93MP0003786_premature_aging1.00897347
94MP0002822_catalepsy1.00314265
95MP0000762_abnormal_tongue_morphology1.00285537
96MP0000462_abnormal_digestive_system0.99970966
97MP0005503_abnormal_tendon_morphology0.98613423
98MP0002092_abnormal_eye_morphology0.98253785
99MP0001672_abnormal_embryogenesis/_devel0.94927223
100MP0005380_embryogenesis_phenotype0.94927223
101MP0000681_abnormal_thyroid_gland0.92384316
102MP0005319_abnormal_enzyme/_coenzyme0.92151505
103MP0003984_embryonic_growth_retardation0.90858020
104MP0001697_abnormal_embryo_size0.89705604
105MP0008007_abnormal_cellular_replicative0.89022417
106MP0002080_prenatal_lethality0.87450230
107MP0002088_abnormal_embryonic_growth/wei0.86753209
108MP0001944_abnormal_pancreas_morphology0.86326149
109MP0005220_abnormal_exocrine_pancreas0.85718282
110MP0000604_amyloidosis0.85328011
111MP0002075_abnormal_coat/hair_pigmentati0.84971413
112MP0003385_abnormal_body_wall0.83842957
113MP0003755_abnormal_palate_morphology0.83778218
114MP0003045_fibrosis0.83679333
115MP0005584_abnormal_enzyme/coenzyme_acti0.83331957
116MP0001186_pigmentation_phenotype0.82560692
117MP0009672_abnormal_birth_weight0.82551049
118MP0005551_abnormal_eye_electrophysiolog0.81947571
119MP0001286_abnormal_eye_development0.81939796
120MP0009046_muscle_twitch0.80976166
121MP0003453_abnormal_keratinocyte_physiol0.77209723
122MP0009780_abnormal_chondrocyte_physiolo0.76994711
123MP0005395_other_phenotype0.76683985
124MP0002160_abnormal_reproductive_system0.76648537
125MP0003868_abnormal_feces_composition0.75070189
126MP0001756_abnormal_urination0.74026996
127MP0001849_ear_inflammation0.73526196
128MP0000579_abnormal_nail_morphology0.71924002
129MP0003119_abnormal_digestive_system0.71201580
130MP0002078_abnormal_glucose_homeostasis0.70502475
131MP0005193_abnormal_anterior_eye0.69586698
132MP0006054_spinal_hemorrhage0.69581980
133MP0009643_abnormal_urine_homeostasis0.69146853
134MP0009053_abnormal_anal_canal0.68781798
135MP0004043_abnormal_pH_regulation0.68114305
136MP0000371_diluted_coat_color0.67749476
137MP0002736_abnormal_nociception_after0.67616494
138MP0002233_abnormal_nose_morphology0.67166225
139MP0005330_cardiomyopathy0.66296758
140MP0004147_increased_porphyrin_level0.66112594
141MP0006035_abnormal_mitochondrial_morpho0.64954654
142MP0002877_abnormal_melanocyte_morpholog0.64849377
143MP0001661_extended_life_span0.64313196
144MP0002896_abnormal_bone_mineralization0.63158277
145MP0003329_amyloid_beta_deposits0.61249454
146MP0005647_abnormal_sex_gland0.61154777
147MP0002269_muscular_atrophy0.61121824
148MP0005379_endocrine/exocrine_gland_phen0.59877173
149MP0000858_altered_metastatic_potential0.58567175
150MP0005084_abnormal_gallbladder_morpholo0.57782488
151MP0001177_atelectasis0.56228242
152MP0009745_abnormal_behavioral_response0.55475837
153MP0003123_paternal_imprinting0.55165541
154MP0005636_abnormal_mineral_homeostasis0.55018869
155MP0004084_abnormal_cardiac_muscle0.53535388
156MP0002069_abnormal_eating/drinking_beha0.53122903
157MP0005646_abnormal_pituitary_gland0.52143384
158MP0004264_abnormal_extraembryonic_tissu0.51593538
159MP0002089_abnormal_postnatal_growth/wei0.51284018
160MP0002971_abnormal_brown_adipose0.50388209
161MP0004272_abnormal_basement_membrane0.50109248
162MP0002168_other_aberrant_phenotype0.48760091
163MP0002557_abnormal_social/conspecific_i0.48260418
164MP0000538_abnormal_urinary_bladder0.47060965
165MP0004782_abnormal_surfactant_physiolog0.45961449
166MP0003638_abnormal_response/metabolism_0.44839047
167MP0003635_abnormal_synaptic_transmissio0.43785812
168MP0001968_abnormal_touch/_nociception0.43498172

Predicted human phenotypes

RankGene SetZ-score
1Alopecia of scalp (HP:0002293)6.13182322
2Bilateral sensorineural hearing impairment (HP:0008619)5.45292866
3Parakeratosis (HP:0001036)5.31900750
4Unilateral renal agenesis (HP:0000122)5.18502716
5Absent eyelashes (HP:0000561)5.13773566
6Hypobetalipoproteinemia (HP:0003563)4.63102013
7Follicular hyperkeratosis (HP:0007502)4.26827241
8Abnormality of dental color (HP:0011073)4.09698581
9Reticulocytopenia (HP:0001896)4.04205120
10Absent eyebrow (HP:0002223)4.02755403
11Hypolipoproteinemia (HP:0010981)3.81397306
12Xanthomatosis (HP:0000991)3.67100411
13Intrahepatic cholestasis (HP:0001406)3.66791723
14Recurrent corneal erosions (HP:0000495)3.60294939
15Abnormality of monocarboxylic acid metabolism (HP:0010996)3.55649972
16Deep venous thrombosis (HP:0002625)3.55435039
17Entropion (HP:0000621)3.41112147
18Hyperglycinemia (HP:0002154)3.38796681
19Cheilitis (HP:0100825)3.36807778
20Mitral stenosis (HP:0001718)3.36067933
21Hypoalphalipoproteinemia (HP:0003233)3.29936905
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.28693091
23Hyperlipoproteinemia (HP:0010980)3.27824370
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.16865028
25Erythroderma (HP:0001019)3.13730856
26Pigmentary retinal degeneration (HP:0001146)3.01705706
27Abnormality of cells of the erythroid lineage (HP:0012130)2.95968240
28Hyperammonemia (HP:0001987)2.89082237
29Abnormal number of erythroid precursors (HP:0012131)2.86807343
30Aplasia/Hypoplasia of the sacrum (HP:0008517)2.80320981
31Prolonged neonatal jaundice (HP:0006579)2.71014697
32Abnormality of DNA repair (HP:0003254)2.69819845
33Oligomenorrhea (HP:0000876)2.67100752
34Vacuolated lymphocytes (HP:0001922)2.66691543
35Hydroxyprolinuria (HP:0003080)2.64958452
36Abnormality of proline metabolism (HP:0010907)2.64958452
37Abolished electroretinogram (ERG) (HP:0000550)2.63052034
38Abnormal gallbladder physiology (HP:0012438)2.56897102
39Cholecystitis (HP:0001082)2.56897102
40Chromosomal breakage induced by crosslinking agents (HP:0003221)2.56012355
41Chronic otitis media (HP:0000389)2.55480945
42Conjugated hyperbilirubinemia (HP:0002908)2.54879423
43Hyperglycemia (HP:0003074)2.53484313
44Poikiloderma (HP:0001029)2.53255877
45Abnormality of reticulocytes (HP:0004312)2.50928583
46Premature rupture of membranes (HP:0001788)2.48488247
47Abnormality of pyrimidine metabolism (HP:0004353)2.46376846
48Poor suck (HP:0002033)2.45687172
49Urticaria (HP:0001025)2.45598309
50Myopathic facies (HP:0002058)2.43348426
51Abnormality of aromatic amino acid family metabolism (HP:0004338)2.42732482
52Secondary amenorrhea (HP:0000869)2.41403339
53Horseshoe kidney (HP:0000085)2.41075345
54Abnormality of glycine metabolism (HP:0010895)2.40425221
55Abnormality of serine family amino acid metabolism (HP:0010894)2.40425221
56Tetraparesis (HP:0002273)2.36944331
57Squamous cell carcinoma (HP:0002860)2.34532231
58Absent hair (HP:0002298)2.32912053
59Abnormality of the labia minora (HP:0012880)2.31663599
60Vascular calcification (HP:0004934)2.31501214
61Delayed CNS myelination (HP:0002188)2.30566552
62Back pain (HP:0003418)2.30525858
63Prolonged partial thromboplastin time (HP:0003645)2.29081967
64Right ventricular cardiomyopathy (HP:0011663)2.28553136
65Gout (HP:0001997)2.28455396
66Abnormality of the intrinsic pathway (HP:0010989)2.27674585
67Abnormality of nucleobase metabolism (HP:0010932)2.27598082
68Hyperphosphatemia (HP:0002905)2.27304610
69Hyperventilation (HP:0002883)2.26684192
70Congenital stationary night blindness (HP:0007642)2.25537335
71Cerebral hypomyelination (HP:0006808)2.24042682
72Abnormality of subcutaneous fat tissue (HP:0001001)2.22636350
73Fat malabsorption (HP:0002630)2.21814224
74Palmoplantar hyperkeratosis (HP:0000972)2.20887161
75Cardiovascular calcification (HP:0011915)2.20543776
76Dynein arm defect of respiratory motile cilia (HP:0012255)2.19222316
77Absent/shortened dynein arms (HP:0200106)2.19222316
78Chromsome breakage (HP:0040012)2.18613504
79Abnormality of the common coagulation pathway (HP:0010990)2.18350548
80Abnormality of purine metabolism (HP:0004352)2.18208700
81Abnormality of serum amino acid levels (HP:0003112)2.16477506
82Blepharitis (HP:0000498)2.16284751
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16014075
84Abnormality of alanine metabolism (HP:0010916)2.16014075
85Hyperalaninemia (HP:0003348)2.16014075
86Vertebral arch anomaly (HP:0008438)2.14864656
87Abnormality of the umbilical cord (HP:0010881)2.14239214
88Bile duct proliferation (HP:0001408)2.13902883
89Abnormal biliary tract physiology (HP:0012439)2.13902883
90Erythema (HP:0010783)2.13401525
91Flat acetabular roof (HP:0003180)2.13258509
92CNS hypomyelination (HP:0003429)2.11585467
93Hyperglycinuria (HP:0003108)2.10242171
94Hypoglycemic seizures (HP:0002173)2.08302163
95Progressive muscle weakness (HP:0003323)2.07840427
96Premature ovarian failure (HP:0008209)2.07237517
97Palmar hyperkeratosis (HP:0010765)2.05291065
98Distal lower limb muscle weakness (HP:0009053)2.04016524
99Pterygium (HP:0001059)2.03862127
100Bifid tongue (HP:0010297)2.03783805
101Abnormality of sulfur amino acid metabolism (HP:0004339)2.02626208
102Tubulointerstitial fibrosis (HP:0005576)2.01273545
103Curly hair (HP:0002212)2.01034831
104Trismus (HP:0000211)2.00772536
105Hypoplasia of the pons (HP:0012110)2.00233942
106Abnormality of the pons (HP:0007361)1.99262188
107Ketosis (HP:0001946)1.98885230
108Upper limb muscle weakness (HP:0003484)1.98677711
109Increased serum lactate (HP:0002151)1.97845655
110Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.97544468
111Absent epiphyses (HP:0010577)1.97544468
112Popliteal pterygium (HP:0009756)1.97066038
113Hypercholesterolemia (HP:0003124)1.96396412
114Fibular aplasia (HP:0002990)1.95623670
115Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.95357772
116Pendular nystagmus (HP:0012043)1.93530864
117Hypoplastic pelvis (HP:0008839)1.91126557
118Acute encephalopathy (HP:0006846)1.90836892
119Chorioretinal atrophy (HP:0000533)1.90758931
120Slender long bone (HP:0003100)1.89798983
121Type II lissencephaly (HP:0007260)1.88489276
122Reduced antithrombin III activity (HP:0001976)1.86370975
123Metabolic acidosis (HP:0001942)1.86320091
124Systemic lupus erythematosus (HP:0002725)1.85907977
125Abnormal mitochondria in muscle tissue (HP:0008316)1.85210334
126Delayed gross motor development (HP:0002194)1.84849686
127Complement deficiency (HP:0004431)1.84355050
128Amniotic constriction ring (HP:0009775)1.83474305
129Abnormality of placental membranes (HP:0011409)1.83474305
130Abnormality of fatty-acid metabolism (HP:0004359)1.82129109
131Ileus (HP:0002595)1.80373867
132Global brain atrophy (HP:0002283)1.78770625
133Increased CSF lactate (HP:0002490)1.78363013
134Reticulocytosis (HP:0001923)1.78323907
135Symptomatic seizures (HP:0011145)1.77114683
136Postnatal microcephaly (HP:0005484)1.76840674
137Tongue fasciculations (HP:0001308)1.76486654
138Acute necrotizing encephalopathy (HP:0006965)1.76178548
139Spastic diplegia (HP:0001264)1.75763168
140Breech presentation (HP:0001623)1.74733992
141Epileptic encephalopathy (HP:0200134)1.73824657
142Plantar hyperkeratosis (HP:0007556)1.73107938
143Long palpebral fissure (HP:0000637)1.71740615
144Abnormalities of placenta or umbilical cord (HP:0001194)1.71675345
145Long toe (HP:0010511)1.70744883
146Hyperuricemia (HP:0002149)1.70671033
147Increased purine levels (HP:0004368)1.70671033
148Cholelithiasis (HP:0001081)1.70281302
149Limb-girdle muscle atrophy (HP:0003797)1.69746084
150Abnormality of glycolysis (HP:0004366)1.69409987
151Increased serum pyruvate (HP:0003542)1.69409987
152Proximal tubulopathy (HP:0000114)1.69276952
153Athetosis (HP:0002305)1.67788128
154Disproportionate short-trunk short stature (HP:0003521)1.67082145
155Nonimmune hydrops fetalis (HP:0001790)1.66681318
156Adrenal hypoplasia (HP:0000835)1.66341782
157Abnormal tarsal ossification (HP:0008369)1.65553395
158Personality changes (HP:0000751)1.64920303
159Abnormal umbilical cord blood vessels (HP:0011403)1.64685784
160Single umbilical artery (HP:0001195)1.64685784
161Abnormality of the fetal cardiovascular system (HP:0010948)1.64685784
162Sensorimotor neuropathy (HP:0007141)1.64518730
163Renal duplication (HP:0000075)1.64079637
164Cutaneous melanoma (HP:0012056)1.63880698
165Abnormal gallbladder morphology (HP:0012437)1.63115478
166Hypoplasia of the capital femoral epiphysis (HP:0003090)1.62627534
167Achilles tendon contracture (HP:0001771)1.62441408
168Overriding aorta (HP:0002623)1.61257204
169Myelomeningocele (HP:0002475)1.60644723
170Decreased subcutaneous fat (HP:0001002)1.59266691
171Absent thumb (HP:0009777)1.58904724
172Esophageal varix (HP:0002040)1.57429168
173Glossoptosis (HP:0000162)1.56534544
174Vertebral compression fractures (HP:0002953)1.55604992
175Birth length less than 3rd percentile (HP:0003561)1.52754869
176Stridor (HP:0010307)1.51917913
177Increased hepatocellular lipid droplets (HP:0006565)1.51656210
178Abnormality of the tricuspid valve (HP:0001702)1.50942605
179Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.50702862
180Self-mutilation (HP:0000742)1.48582216
181Blindness (HP:0000618)1.47437120
182Hand muscle atrophy (HP:0009130)1.46592510
183Microglossia (HP:0000171)1.42913758
184Abnormality of carpal bone ossification (HP:0006257)1.42017353
185Anophthalmia (HP:0000528)1.41150649
186Protrusio acetabuli (HP:0003179)1.41019007

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.07494328
2SIK14.62191217
3VRK24.39547436
4NME24.24197419
5SIK34.22074365
6SIK23.00265913
7IRAK32.78624992
8RPS6KB22.40777559
9MARK32.38231120
10PAK42.31451520
11MAPKAPK32.28832168
12LATS12.27989140
13NEK12.27707091
14STK162.17116122
15LATS22.16494144
16STK38L2.15698626
17SMG12.15484424
18AKT32.13529337
19EPHA42.12071330
20TESK22.08819375
21LIMK12.06690431
22NME12.04267031
23BRAF2.03609065
24CASK1.90367206
25TAOK21.87245490
26EPHA31.84814050
27PDK31.76088780
28PDK41.76088780
29TSSK61.72090254
30PLK21.70003116
31PRPF4B1.65316157
32EEF2K1.61639529
33MAP3K131.56392387
34BCKDK1.41024736
35ABL21.40183886
36FRK1.38602822
37ARAF1.29398255
38PRKCG1.29251149
39PTK21.28743154
40ICK1.27831102
41BRSK21.27312764
42DAPK21.26065719
43DYRK21.25665019
44FER1.25197881
45EIF2AK11.24371883
46SRPK11.22959417
47NEK21.14772434
48MAP3K111.11912057
49TYK21.10042067
50LMTK21.08593720
51TTK1.08278069
52PTK61.07840921
53PBK1.05400595
54PRKG21.04118017
55MAP3K91.02917803
56ERN11.01331462
57BUB10.99944734
58MUSK0.97770256
59BRSK10.97093593
60AURKA0.96745764
61PRKD30.96342920
62MAP3K50.96084645
63PLK30.96077710
64SGK20.95579163
65PHKG20.93002392
66PHKG10.93002392
67PRKCZ0.88910537
68ADRBK20.86959253
69MAP3K120.84547276
70TESK10.83587688
71TAF10.82801395
72MAP2K40.82056768
73CCNB10.81214327
74NTRK30.79076738
75MAP3K140.79010583
76CDK90.78661387
77CAMK2G0.78448577
78WNK40.77323713
79PDK20.76328742
80SCYL20.75231803
81DYRK30.75055388
82STK380.73922231
83ILK0.73423346
84KSR20.70333531
85EIF2AK30.69030085
86TYRO30.68280837
87PLK10.67811913
88MTOR0.67401129
89INSRR0.65058518
90SGK30.64707363
91NEK90.63109128
92PLK40.62208912
93VRK10.62037612
94AURKB0.61399700
95MAP3K30.60824394
96MAP2K10.59989840
97CDK70.59458571
98PIM20.58689576
99TRIB30.58468948
100SGK2230.57687555
101SGK4940.57687555
102PRKCI0.57176423
103CAMK2D0.56421810
104CLK10.56209825
105ATR0.54489357
106CDK80.54382424
107MST1R0.51323978
108CHEK10.51267664
109ALK0.49939455
110RPS6KA20.49818148
111MAP3K80.49019856
112TAOK10.48146265
113MAPKAPK50.47874163
114TTN0.47833538
115MAP3K70.45834275
116RIPK10.44773826
117PRKCE0.43847656
118RAF10.43759613
119CSNK1G10.42904998
120ERBB40.42416320
121CHEK20.40577483
122ADRBK10.40000946
123CSNK1A10.39629446
124PAK30.39179457
125CSNK2A20.38825844
126AKT20.38715513
127DAPK30.38336145
128BRD40.37609498
129GRK60.37294276
130TBK10.36157205
131MAPK110.36069908
132CSNK1E0.35246359
133PRKAA10.35223061
134MINK10.34919178
135PRKCH0.34903584
136DYRK1B0.34841385
137PKN20.34796073
138CSNK2A10.34371259
139EIF2AK20.34342894
140MKNK20.34063832
141STK30.31977707
142CDK40.30462316
143CDK10.30206722
144NUAK10.29418835
145DDR20.29183302
146MAP2K60.28908938
147DAPK10.26858712
148MAP3K40.26812958
149TRPM70.26653993
150CSNK1D0.26251672
151FGFR10.26240636
152PAK10.26211744
153RPS6KA40.23802375
154MAP2K30.22753146
155EPHB20.22553893
156SGK10.22218498
157JAK10.21643010
158MAPK70.21234601
159PRKCA0.20592283
160CSNK1A1L0.20224877
161WNK30.19269358

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.87782545
2Arginine biosynthesis_Homo sapiens_hsa002203.61291640
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.10951551
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.98601162
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.84185005
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.79637365
7Nitrogen metabolism_Homo sapiens_hsa009102.71639063
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.54769624
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.15854036
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.12164402
11Ribosome_Homo sapiens_hsa030102.08874287
12Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.07428531
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.02487006
14Synaptic vesicle cycle_Homo sapiens_hsa047211.96125402
15Fat digestion and absorption_Homo sapiens_hsa049751.94835325
16DNA replication_Homo sapiens_hsa030301.94437812
17Carbon metabolism_Homo sapiens_hsa012001.90204566
18Biosynthesis of amino acids_Homo sapiens_hsa012301.89912259
19Oxidative phosphorylation_Homo sapiens_hsa001901.88359173
20RNA polymerase_Homo sapiens_hsa030201.81758636
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.80753162
22Pyruvate metabolism_Homo sapiens_hsa006201.77169499
23Caffeine metabolism_Homo sapiens_hsa002321.74631765
24Nicotine addiction_Homo sapiens_hsa050331.71806934
25Vitamin digestion and absorption_Homo sapiens_hsa049771.58270172
26Proteasome_Homo sapiens_hsa030501.57088746
27Fructose and mannose metabolism_Homo sapiens_hsa000511.54282570
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.51609883
29Mineral absorption_Homo sapiens_hsa049781.51317672
30Fatty acid elongation_Homo sapiens_hsa000621.50924251
31Pyrimidine metabolism_Homo sapiens_hsa002401.44987689
32Tryptophan metabolism_Homo sapiens_hsa003801.44422418
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43757266
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43717206
35RNA transport_Homo sapiens_hsa030131.43513038
36Complement and coagulation cascades_Homo sapiens_hsa046101.43409105
37Nucleotide excision repair_Homo sapiens_hsa034201.42005555
38Fatty acid degradation_Homo sapiens_hsa000711.41569134
39Base excision repair_Homo sapiens_hsa034101.40402617
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38880214
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.37105113
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36366710
43PPAR signaling pathway_Homo sapiens_hsa033201.35711854
44Mismatch repair_Homo sapiens_hsa034301.35259887
45Peroxisome_Homo sapiens_hsa041461.34789055
46Protein export_Homo sapiens_hsa030601.34417474
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33776758
48Propanoate metabolism_Homo sapiens_hsa006401.33538904
49Pentose phosphate pathway_Homo sapiens_hsa000301.32859019
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.31861557
51Folate biosynthesis_Homo sapiens_hsa007901.30792310
52Parkinsons disease_Homo sapiens_hsa050121.29269567
53Drug metabolism - other enzymes_Homo sapiens_hsa009831.25609634
54Fatty acid metabolism_Homo sapiens_hsa012121.25205195
55Selenocompound metabolism_Homo sapiens_hsa004501.23318149
56Retinol metabolism_Homo sapiens_hsa008301.21897379
57Huntingtons disease_Homo sapiens_hsa050161.21242949
58Bile secretion_Homo sapiens_hsa049761.19823023
59N-Glycan biosynthesis_Homo sapiens_hsa005101.19680012
60Other glycan degradation_Homo sapiens_hsa005111.18379977
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16911268
62Spliceosome_Homo sapiens_hsa030401.15595960
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14433924
64Phenylalanine metabolism_Homo sapiens_hsa003601.13868257
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13753766
66Collecting duct acid secretion_Homo sapiens_hsa049661.12642576
67Galactose metabolism_Homo sapiens_hsa000521.10479585
68Butanoate metabolism_Homo sapiens_hsa006501.09307106
69Chemical carcinogenesis_Homo sapiens_hsa052041.07977934
70Starch and sucrose metabolism_Homo sapiens_hsa005001.07759867
71Basal transcription factors_Homo sapiens_hsa030221.07548813
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04271606
73Homologous recombination_Homo sapiens_hsa034401.04118779
74Alzheimers disease_Homo sapiens_hsa050100.98713345
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96788839
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96459572
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94803336
78Staphylococcus aureus infection_Homo sapiens_hsa051500.94621945
79Fanconi anemia pathway_Homo sapiens_hsa034600.92414167
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.88868152
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88302613
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87101362
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86325269
84beta-Alanine metabolism_Homo sapiens_hsa004100.85567029
85Steroid biosynthesis_Homo sapiens_hsa001000.82926271
86One carbon pool by folate_Homo sapiens_hsa006700.82757517
87Arginine and proline metabolism_Homo sapiens_hsa003300.81031408
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70307512
89Sphingolipid metabolism_Homo sapiens_hsa006000.69994502
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69240723
91mRNA surveillance pathway_Homo sapiens_hsa030150.68929057
92Cardiac muscle contraction_Homo sapiens_hsa042600.68217117
93GABAergic synapse_Homo sapiens_hsa047270.68199991
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.66084396
95Type I diabetes mellitus_Homo sapiens_hsa049400.65484086
96p53 signaling pathway_Homo sapiens_hsa041150.65060180
97Fatty acid biosynthesis_Homo sapiens_hsa000610.64678556
98Glycerolipid metabolism_Homo sapiens_hsa005610.64642448
99Purine metabolism_Homo sapiens_hsa002300.63111070
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59000227
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58339791
102Vitamin B6 metabolism_Homo sapiens_hsa007500.58183747
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58183453
104Lysosome_Homo sapiens_hsa041420.57591304
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57357967
106Hippo signaling pathway_Homo sapiens_hsa043900.56890147
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55304308
108Phototransduction_Homo sapiens_hsa047440.52666842
109Sulfur relay system_Homo sapiens_hsa041220.50305880
110Non-homologous end-joining_Homo sapiens_hsa034500.45793642
111Vibrio cholerae infection_Homo sapiens_hsa051100.45641706
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45085813
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.44243105
114Hedgehog signaling pathway_Homo sapiens_hsa043400.43885129
115Protein digestion and absorption_Homo sapiens_hsa049740.41754191
116ECM-receptor interaction_Homo sapiens_hsa045120.41515067
117Sulfur metabolism_Homo sapiens_hsa009200.39921981
118Basal cell carcinoma_Homo sapiens_hsa052170.38840026
119Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38823248
120Cell cycle_Homo sapiens_hsa041100.38613920
121RNA degradation_Homo sapiens_hsa030180.38069434
122Bladder cancer_Homo sapiens_hsa052190.37992286
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.35422217
124Glucagon signaling pathway_Homo sapiens_hsa049220.35179155
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34697301
126Tight junction_Homo sapiens_hsa045300.33384384
127Metabolic pathways_Homo sapiens_hsa011000.32823082
128Tyrosine metabolism_Homo sapiens_hsa003500.31650123
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30759784
130Rheumatoid arthritis_Homo sapiens_hsa053230.30075016
131Melanoma_Homo sapiens_hsa052180.28862706
132Lysine degradation_Homo sapiens_hsa003100.28458176
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.26415687
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.23872201
135HIF-1 signaling pathway_Homo sapiens_hsa040660.23365180
136Morphine addiction_Homo sapiens_hsa050320.23046620
137Long-term potentiation_Homo sapiens_hsa047200.20744056
138Toll-like receptor signaling pathway_Homo sapiens_hsa046200.20120143
139Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19383031
140Phagosome_Homo sapiens_hsa041450.19158232
141Insulin secretion_Homo sapiens_hsa049110.18224830
142Dilated cardiomyopathy_Homo sapiens_hsa054140.17969456
143Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17190911
144Insulin resistance_Homo sapiens_hsa049310.16512049
145Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.14706139
146Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14599185
147Glutathione metabolism_Homo sapiens_hsa004800.14332178

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