RNF122

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The encoded protein contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The encoded protein is localized to the endoplasmic reticulum and golgi apparatus, and may be associated with cell viability. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.53611350
2central nervous system myelination (GO:0022010)9.53611350
3myelination (GO:0042552)6.91705720
4ensheathment of neurons (GO:0007272)6.86414660
5axon ensheathment (GO:0008366)6.86414660
6fatty acid elongation (GO:0030497)6.04567818
7behavioral response to nicotine (GO:0035095)5.40799666
8regulation of collateral sprouting (GO:0048670)5.34909011
9DNA deamination (GO:0045006)5.26068003
10activated T cell proliferation (GO:0050798)5.14862034
11peripheral nervous system axon ensheathment (GO:0032292)5.04371148
12myelination in peripheral nervous system (GO:0022011)5.04371148
13somite development (GO:0061053)4.95107803
14long-chain fatty acid biosynthetic process (GO:0042759)4.89647051
15cell proliferation in forebrain (GO:0021846)4.84138387
16cholesterol biosynthetic process (GO:0006695)4.65147272
17oligodendrocyte differentiation (GO:0048709)4.59834700
18negative regulation of neurotransmitter secretion (GO:0046929)4.56223347
19eye photoreceptor cell differentiation (GO:0001754)4.50429965
20photoreceptor cell differentiation (GO:0046530)4.50429965
21limb bud formation (GO:0060174)4.43976212
22negative regulation of axon extension (GO:0030517)4.29266593
23glycerophospholipid catabolic process (GO:0046475)4.26710858
24response to redox state (GO:0051775)4.24334925
25positive regulation of actin filament depolymerization (GO:0030836)4.23349286
26cellular response to hepatocyte growth factor stimulus (GO:0035729)4.21795781
27response to hepatocyte growth factor (GO:0035728)4.21795781
28negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.21284089
29adhesion of symbiont to host cell (GO:0044650)4.11281647
30virion attachment to host cell (GO:0019062)4.11281647
31presynaptic membrane assembly (GO:0097105)4.05765352
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.03647040
33mitochondrial respiratory chain complex I assembly (GO:0032981)4.03647040
34NADH dehydrogenase complex assembly (GO:0010257)4.03647040
35negative regulation of axon extension involved in axon guidance (GO:0048843)3.96536762
36presynaptic membrane organization (GO:0097090)3.96037249
37substantia nigra development (GO:0021762)3.95363734
38protein polyglutamylation (GO:0018095)3.94700389
39sterol biosynthetic process (GO:0016126)3.91726920
40histone H2B ubiquitination (GO:0033523)3.85541479
41regulation of sequestering of triglyceride (GO:0010889)3.85195677
42positive regulation of oligodendrocyte differentiation (GO:0048714)3.82613787
43isoprenoid biosynthetic process (GO:0008299)3.81918004
44positive regulation of glomerulus development (GO:0090193)3.76947035
45negative regulation of axon guidance (GO:1902668)3.76068908
46branching involved in labyrinthine layer morphogenesis (GO:0060670)3.69314991
47negative regulation of telomerase activity (GO:0051974)3.68420175
48L-amino acid import (GO:0043092)3.62290461
49regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.62206470
50astrocyte development (GO:0014002)3.58809854
51negative regulation of axonogenesis (GO:0050771)3.56406587
52endoderm formation (GO:0001706)3.56307385
53regulation of glomerulus development (GO:0090192)3.48343796
54regulation of female receptivity (GO:0045924)3.47092464
55negative regulation of myoblast differentiation (GO:0045662)3.45854099
56transmission of nerve impulse (GO:0019226)3.38656901
57neuron cell-cell adhesion (GO:0007158)3.38447308
58apical protein localization (GO:0045176)3.35605186
59chaperone-mediated protein transport (GO:0072321)3.34686800
60protein complex biogenesis (GO:0070271)3.34425004
61asymmetric protein localization (GO:0008105)3.33693985
62regulation of somitogenesis (GO:0014807)3.33056748
63creatine metabolic process (GO:0006600)3.32309100
64cellular response to epinephrine stimulus (GO:0071872)3.30069259
65negative regulation of neurotransmitter transport (GO:0051589)3.29051497
66lung morphogenesis (GO:0060425)3.28384688
67multicellular organism reproduction (GO:0032504)3.26818814
68peptidyl-tyrosine autophosphorylation (GO:0038083)3.24339242
69neuronal ion channel clustering (GO:0045161)3.21443851
70membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.20773753
71cranial nerve morphogenesis (GO:0021602)3.19568399
72neural nucleus development (GO:0048857)3.17699715
73negative regulation of protein localization to cell surface (GO:2000009)3.16493645
74ear development (GO:0043583)3.16434293
75negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.15570596
76cerebral cortex radially oriented cell migration (GO:0021799)3.15177276
77positive regulation of action potential (GO:0045760)3.13636185
78nucleotide transmembrane transport (GO:1901679)3.13459839
79semaphorin-plexin signaling pathway (GO:0071526)3.12515027
80regulation of germinal center formation (GO:0002634)3.12430738
81positive regulation of neurological system process (GO:0031646)3.09592857
82negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.09332819
83cytidine deamination (GO:0009972)3.08231134
84cytidine metabolic process (GO:0046087)3.08231134
85cytidine catabolic process (GO:0006216)3.08231134
86regulation of telomerase activity (GO:0051972)3.06816962
87DNA methylation involved in gamete generation (GO:0043046)3.05676142
88glial cell development (GO:0021782)3.04615057
89positive regulation of defense response to virus by host (GO:0002230)3.02713174
90dentate gyrus development (GO:0021542)3.00887168
91adaptation of signaling pathway (GO:0023058)2.99792589
92negative regulation of mast cell activation (GO:0033004)2.99221382
93pharyngeal system development (GO:0060037)2.97635259
94piRNA metabolic process (GO:0034587)2.96978826
95positive regulation of fatty acid oxidation (GO:0046321)2.96962158
96regulation of acrosome reaction (GO:0060046)2.95776917
97regulation of cholesterol storage (GO:0010885)2.95456298
98regulation of oligodendrocyte differentiation (GO:0048713)2.95035911
99protein palmitoylation (GO:0018345)2.94636785
100amyloid precursor protein metabolic process (GO:0042982)2.94269496
101Rap protein signal transduction (GO:0032486)2.94072802
102female mating behavior (GO:0060180)2.91474520
103negative regulation of interleukin-10 production (GO:0032693)2.91469729
104peripheral nervous system development (GO:0007422)2.91468137
105import into cell (GO:0098657)2.91201614
106negative regulation of transcription regulatory region DNA binding (GO:2000678)2.90352148
107spinal cord development (GO:0021510)2.89075403
108adhesion of symbiont to host (GO:0044406)2.87955132
109negative regulation of lipid storage (GO:0010888)2.87582995
110viral transcription (GO:0019083)2.86971695
111lateral sprouting from an epithelium (GO:0060601)2.85327150
112positive regulation of meiosis (GO:0045836)2.83996412
113positive regulation of interleukin-17 production (GO:0032740)2.83768764
114negative regulation of astrocyte differentiation (GO:0048712)2.83618603
115mitochondrial respiratory chain complex assembly (GO:0033108)2.82464549
116amyloid precursor protein catabolic process (GO:0042987)2.81512233
117lens fiber cell development (GO:0070307)2.81439808
118cranial nerve development (GO:0021545)2.81050658
119response to caffeine (GO:0031000)2.80441461
120myelin maintenance (GO:0043217)2.79289746
121regulation of myelination (GO:0031641)2.78861366
122enteric nervous system development (GO:0048484)2.78757346
123preassembly of GPI anchor in ER membrane (GO:0016254)2.77958537
124forebrain neuron differentiation (GO:0021879)2.77695814
125regulation of mesoderm development (GO:2000380)2.77603882
126microtubule polymerization or depolymerization (GO:0031109)2.77479847
127Leydig cell differentiation (GO:0033327)2.76733241
128regulation of female gonad development (GO:2000194)2.75190500
129amino acid import (GO:0043090)2.75131638
130pyrimidine ribonucleoside catabolic process (GO:0046133)2.73839156
131positive regulation of glial cell differentiation (GO:0045687)2.73768238
132substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.73580500
133substrate-independent telencephalic tangential migration (GO:0021826)2.73580500
134leukocyte migration involved in inflammatory response (GO:0002523)2.73181995
135base-excision repair, AP site formation (GO:0006285)2.72590049
136cellular response to ATP (GO:0071318)2.72581692
137mannosylation (GO:0097502)2.71904890
138negative regulation of systemic arterial blood pressure (GO:0003085)2.70445663
139GPI anchor biosynthetic process (GO:0006506)2.70096513
140synaptic transmission, cholinergic (GO:0007271)2.69590986
141positive regulation of meiotic cell cycle (GO:0051446)2.69547842
142response to epinephrine (GO:0071871)2.68743133
143positive regulation of T cell apoptotic process (GO:0070234)2.68394012
144female gonad development (GO:0008585)2.67421849
145protein neddylation (GO:0045116)2.65950535
146regulation of receptor binding (GO:1900120)2.64440079
147water-soluble vitamin biosynthetic process (GO:0042364)2.63250802
148response to lipoprotein particle (GO:0055094)2.61522800
149glial cell differentiation (GO:0010001)2.60851076
150positive regulation of potassium ion transmembrane transport (GO:1901381)2.59781557
151forebrain morphogenesis (GO:0048853)2.59141348
152organ growth (GO:0035265)2.58955456
153pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.58586730
154regulation of cell maturation (GO:1903429)2.58586161
155epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.57718392
156negative regulation of cardiac muscle tissue growth (GO:0055022)2.57656376
157negative regulation of heart growth (GO:0061117)2.57656376
158phosphatidylinositol 3-kinase signaling (GO:0014065)2.56057058
159ribosomal small subunit assembly (GO:0000028)2.55369899
160membrane protein ectodomain proteolysis (GO:0006509)2.52812006
161translational termination (GO:0006415)2.52243980
162pyrimidine nucleobase catabolic process (GO:0006208)2.51721646
163spinal cord motor neuron differentiation (GO:0021522)2.51571833
164RNA destabilization (GO:0050779)2.51539794
165negative regulation of appetite (GO:0032099)2.50853385
166negative regulation of response to food (GO:0032096)2.50853385
167positive regulation of catenin import into nucleus (GO:0035413)2.50046813
168sulfation (GO:0051923)2.49919456
169negative regulation of execution phase of apoptosis (GO:1900118)2.48161507
170head development (GO:0060322)2.46594025
171pituitary gland development (GO:0021983)2.46224418
172negative regulation of telomere maintenance (GO:0032205)2.44292080
173ribosomal small subunit biogenesis (GO:0042274)2.43898179
174GPI anchor metabolic process (GO:0006505)2.43265431
175brown fat cell differentiation (GO:0050873)2.41735698
176indolalkylamine metabolic process (GO:0006586)2.41724833
177positive regulation of humoral immune response (GO:0002922)2.41408545
178tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.40735712
179RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.40735712
180cellular response to lithium ion (GO:0071285)2.40327788
181mitochondrion morphogenesis (GO:0070584)2.39485796
182negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.38051487
183positive regulation of cAMP-mediated signaling (GO:0043950)2.37448693
184positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.36846512
185regulation of action potential (GO:0098900)2.35030626
186parturition (GO:0007567)2.31028228
187negative regulation of DNA-templated transcription, elongation (GO:0032785)2.29464722
188white fat cell differentiation (GO:0050872)2.28795650
189kynurenine metabolic process (GO:0070189)2.28463132
190serine family amino acid catabolic process (GO:0009071)2.28119460
191middle ear morphogenesis (GO:0042474)2.27679482
192appendage development (GO:0048736)2.27243005
193limb development (GO:0060173)2.27243005
194dorsal/ventral pattern formation (GO:0009953)2.26445447
195pyrimidine nucleotide catabolic process (GO:0006244)2.25889466

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.60128019
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.39797271
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.43385849
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.16640850
5GBX2_23144817_ChIP-Seq_PC3_Human2.88237232
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.77363238
7CBX2_27304074_Chip-Seq_ESCs_Mouse2.75878703
8SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.49852884
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.49358794
10PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.46019233
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.39897384
12TAF15_26573619_Chip-Seq_HEK293_Human2.37932405
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.28123891
14POU5F1_16153702_ChIP-ChIP_HESCs_Human2.22397917
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.22259879
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.19432009
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16228053
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16228053
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.14308076
20RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.11576173
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.08553123
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.07880279
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.04172217
24ZNF274_21170338_ChIP-Seq_K562_Hela2.01552562
25WT1_19549856_ChIP-ChIP_CCG9911_Human2.00620957
26RNF2_27304074_Chip-Seq_NSC_Mouse1.99321199
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.97595649
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95139087
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.94019149
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92177332
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91122294
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.91079075
33AR_21572438_ChIP-Seq_LNCaP_Human1.86061760
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.84062719
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.78631410
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.73015762
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.72119569
38FUS_26573619_Chip-Seq_HEK293_Human1.71956668
39EZH2_22144423_ChIP-Seq_EOC_Human1.71318074
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.69646166
41* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.68944584
42ER_23166858_ChIP-Seq_MCF-7_Human1.68691063
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66653607
44TP53_20018659_ChIP-ChIP_R1E_Mouse1.65992967
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63310396
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62983554
47REST_21632747_ChIP-Seq_MESCs_Mouse1.59305092
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.56537030
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.53902771
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.50191359
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47998966
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.47183125
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45065715
54* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42282328
55TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41941074
56SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.40390990
57VDR_22108803_ChIP-Seq_LS180_Human1.40078435
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39951858
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39951858
60P300_19829295_ChIP-Seq_ESCs_Human1.39141214
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38863054
62SOX2_16153702_ChIP-ChIP_HESCs_Human1.33753259
63MYC_18940864_ChIP-ChIP_HL60_Human1.32849821
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32768096
65SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.32727796
66RING1B_27294783_Chip-Seq_NPCs_Mouse1.30501783
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30482163
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30340917
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.30176112
70STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.29171169
71NANOG_20526341_ChIP-Seq_ESCs_Human1.28325213
72AUTS2_25519132_ChIP-Seq_293T-REX_Human1.28252571
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28135822
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.28075614
75RUNX_20019798_ChIP-Seq_JUKART_Human1.25415192
76BCL6_27268052_Chip-Seq_Bcells_Human1.24810301
77LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22997109
78IRF8_21731497_ChIP-ChIP_J774_Mouse1.22716081
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22133912
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21931721
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21601433
82TAF2_19829295_ChIP-Seq_ESCs_Human1.19371959
83EWS_26573619_Chip-Seq_HEK293_Human1.18024498
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.17463162
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16424993
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16224277
87* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15857948
88TAL1_26923725_Chip-Seq_HPCs_Mouse1.15018788
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14958352
90NCOR_22424771_ChIP-Seq_293T_Human1.14678810
91* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13735977
92GATA1_26923725_Chip-Seq_HPCs_Mouse1.13634594
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13145245
94TDRD3_21172665_ChIP-Seq_MCF-7_Human1.12933801
95YY1_22570637_ChIP-Seq_MALME-3M_Human1.12816962
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12364877
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10789819
98P300_18555785_Chip-Seq_ESCs_Mouse1.10278459
99KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09535161
100GATA3_21878914_ChIP-Seq_MCF-7_Human1.08815387
101CMYC_18555785_Chip-Seq_ESCs_Mouse1.08408124
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07799980
103LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06369002
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05756634
105TP53_22573176_ChIP-Seq_HFKS_Human1.03403794
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03383424
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03311251
108RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03137246
109* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02640244
110RING1B_27294783_Chip-Seq_ESCs_Mouse1.01093036
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00296669
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00098242
113EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99288272
114FOXH1_21741376_ChIP-Seq_ESCs_Human0.98998806
115SOX9_26525672_Chip-Seq_HEART_Mouse0.98900225
116DROSHA_22980978_ChIP-Seq_HELA_Human0.97421546
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96438008
118IGF1R_20145208_ChIP-Seq_DFB_Human0.95974788
119ERA_21632823_ChIP-Seq_H3396_Human0.95939418
120IRF1_19129219_ChIP-ChIP_H3396_Human0.95004458
121STAT1_20625510_ChIP-Seq_HELA_Human0.93891516
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93858397
123TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92796456
124P53_22387025_ChIP-Seq_ESCs_Mouse0.92415892
125PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91398641
126RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90539565
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90321830
128EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90260127
129* CTCF_20526341_ChIP-Seq_ESCs_Human0.90166795
130GF1B_26923725_Chip-Seq_HPCs_Mouse0.90058285
131EOMES_21245162_ChIP-Seq_HESCs_Human0.89903385
132GABP_17652178_ChIP-ChIP_JURKAT_Human0.89802184
133TBL1_22424771_ChIP-Seq_293T_Human0.88945671
134E2F1_18555785_Chip-Seq_ESCs_Mouse0.88724479
135PRDM14_20953172_ChIP-Seq_ESCs_Human0.88662698
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87925170
137PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87285396
138EP300_21415370_ChIP-Seq_HL-1_Mouse0.86363217
139RAC3_21632823_ChIP-Seq_H3396_Human0.86358051
140RUNX2_22187159_ChIP-Seq_PCA_Human0.86182906
141POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.85700041
142CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.85252252
143CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85150872
144SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85018217
145STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84718354
146CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84577232
147E2F1_20622854_ChIP-Seq_HELA_Human0.83800855
148YY1_21170310_ChIP-Seq_MESCs_Mouse0.83600815
149CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83487219
150RUNX1_27457419_Chip-Seq_LIVER_Mouse0.83418992
151EZH2_27294783_Chip-Seq_NPCs_Mouse0.83072510
152AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83001702
153OCT4_19829295_ChIP-Seq_ESCs_Human0.82774706
154EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.82465360
155SMRT_27268052_Chip-Seq_Bcells_Human0.81858924
156MYC_19829295_ChIP-Seq_ESCs_Human0.81846401
157P68_20966046_ChIP-Seq_HELA_Human0.81030820
158FOXA1_25329375_ChIP-Seq_VCAP_Human0.81001978
159FOXA1_27270436_Chip-Seq_PROSTATE_Human0.81001978
160UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.79823936
161RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79330037
162P300_27268052_Chip-Seq_Bcells_Human0.79076353
163TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78953709
164GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77076686

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.09086871
2MP0003724_increased_susceptibility_to3.75447418
3MP0003136_yellow_coat_color3.51628011
4MP0000566_synostosis3.22031766
5MP0003646_muscle_fatigue3.19694464
6MP0001529_abnormal_vocalization3.14856540
7MP0000778_abnormal_nervous_system3.04153777
8MP0005171_absent_coat_pigmentation2.93688742
9MP0004742_abnormal_vestibular_system2.90612637
10MP0002138_abnormal_hepatobiliary_system2.78569361
11MP0005670_abnormal_white_adipose2.64254181
12MP0003880_abnormal_central_pattern2.62138873
13MP0001905_abnormal_dopamine_level2.46139657
14MP0002837_dystrophic_cardiac_calcinosis2.36007306
15MP0003690_abnormal_glial_cell2.32495426
16MP0004885_abnormal_endolymph2.29377344
17MP0001485_abnormal_pinna_reflex2.26263629
18MP0005409_darkened_coat_color2.26159607
19MP0004130_abnormal_muscle_cell2.19914585
20MP0004381_abnormal_hair_follicle2.18054081
21MP0000462_abnormal_digestive_system2.17368850
22MP0009379_abnormal_foot_pigmentation2.04920816
23MP0002102_abnormal_ear_morphology2.01601273
24MP0004134_abnormal_chest_morphology1.96748351
25MP0003937_abnormal_limbs/digits/tail_de1.95116951
26MP0005671_abnormal_response_to1.89465933
27MP0000383_abnormal_hair_follicle1.88175593
28MP0008877_abnormal_DNA_methylation1.88127920
29MP0010030_abnormal_orbit_morphology1.82417325
30MP0009053_abnormal_anal_canal1.81189087
31MP0003879_abnormal_hair_cell1.78647104
32MP0003938_abnormal_ear_development1.76043995
33MP0004270_analgesia1.74250062
34MP0001486_abnormal_startle_reflex1.72823559
35MP0003950_abnormal_plasma_membrane1.69559609
36MP0002653_abnormal_ependyma_morphology1.69521964
37MP0005394_taste/olfaction_phenotype1.67885723
38MP0005499_abnormal_olfactory_system1.67885723
39MP0004145_abnormal_muscle_electrophysio1.67713784
40MP0002938_white_spotting1.65134714
41MP0003634_abnormal_glial_cell1.64892684
42MP0001346_abnormal_lacrimal_gland1.64306569
43MP0002160_abnormal_reproductive_system1.61485190
44MP0003787_abnormal_imprinting1.61479056
45MP0005389_reproductive_system_phenotype1.57730234
46MP0003119_abnormal_digestive_system1.57594770
47MP0002272_abnormal_nervous_system1.52183780
48MP0002752_abnormal_somatic_nervous1.51121832
49MP0003385_abnormal_body_wall1.50314799
50MP0000013_abnormal_adipose_tissue1.48912064
51MP0009250_abnormal_appendicular_skeleto1.48295410
52MP0002751_abnormal_autonomic_nervous1.47976706
53MP0002876_abnormal_thyroid_physiology1.45389769
54MP0000026_abnormal_inner_ear1.40816497
55MP0000678_abnormal_parathyroid_gland1.39300375
56MP0000537_abnormal_urethra_morphology1.38340846
57MP0005451_abnormal_body_composition1.38254213
58MP0004142_abnormal_muscle_tone1.37448351
59MP0003315_abnormal_perineum_morphology1.35706673
60MP0001963_abnormal_hearing_physiology1.32284050
61MP0002882_abnormal_neuron_morphology1.31413605
62MP0001299_abnormal_eye_distance/1.31047424
63MP0001919_abnormal_reproductive_system1.30038372
64MP0002277_abnormal_respiratory_mucosa1.29149007
65MP0001986_abnormal_taste_sensitivity1.26042510
66MP0010678_abnormal_skin_adnexa1.23621815
67MP0009765_abnormal_xenobiotic_induced1.23607188
68MP0002638_abnormal_pupillary_reflex1.23503725
69MP0005423_abnormal_somatic_nervous1.22064519
70MP0004133_heterotaxia1.21850398
71MP0000631_abnormal_neuroendocrine_gland1.21693558
72MP0000955_abnormal_spinal_cord1.20419432
73MP0003632_abnormal_nervous_system1.18672668
74MP0001968_abnormal_touch/_nociception1.17685468
75MP0000647_abnormal_sebaceous_gland1.17573285
76MP0006276_abnormal_autonomic_nervous1.17314567
77MP0003861_abnormal_nervous_system1.16523752
78MP0003122_maternal_imprinting1.15558789
79MP0008789_abnormal_olfactory_epithelium1.15437212
80MP0000372_irregular_coat_pigmentation1.13375765
81MP0006072_abnormal_retinal_apoptosis1.12948506
82MP0000762_abnormal_tongue_morphology1.12879381
83MP0000467_abnormal_esophagus_morphology1.12867350
84MP0001800_abnormal_humoral_immune1.12384961
85MP0000049_abnormal_middle_ear1.09522392
86MP0005623_abnormal_meninges_morphology1.08632287
87MP0002249_abnormal_larynx_morphology1.06499857
88MP0003011_delayed_dark_adaptation1.05434213
89MP0001661_extended_life_span1.04299781
90MP0001293_anophthalmia1.02467093
91MP0005367_renal/urinary_system_phenotyp1.01335086
92MP0000516_abnormal_urinary_system1.01335086
93MP0001984_abnormal_olfaction1.01098531
94MP0008057_abnormal_DNA_replication1.00700284
95MP0003755_abnormal_palate_morphology1.00131057
96MP0005195_abnormal_posterior_eye0.98829233
97MP0005000_abnormal_immune_tolerance0.98699171
98MP0002229_neurodegeneration0.97403888
99MP0002932_abnormal_joint_morphology0.97358532
100MP0002282_abnormal_trachea_morphology0.96823859
101MP0006292_abnormal_olfactory_placode0.96190893
102MP0005377_hearing/vestibular/ear_phenot0.96067165
103MP0003878_abnormal_ear_physiology0.96067165
104MP0002064_seizures0.96055848
105MP0003121_genomic_imprinting0.95871555
106MP0002152_abnormal_brain_morphology0.95672649
107MP0001727_abnormal_embryo_implantation0.95338320
108MP0004147_increased_porphyrin_level0.93912015
109MP0000733_abnormal_muscle_development0.92909657
110MP0002177_abnormal_outer_ear0.92700162
111MP0002184_abnormal_innervation0.92049687
112MP0005551_abnormal_eye_electrophysiolog0.90716699
113MP0009785_altered_susceptibility_to0.90498072
114MP0005387_immune_system_phenotype0.90478650
115MP0001790_abnormal_immune_system0.90478650
116MP0002233_abnormal_nose_morphology0.89207299
117MP0005408_hypopigmentation0.88451974
118MP0002734_abnormal_mechanical_nocicepti0.88314108
119MP0002723_abnormal_immune_serum0.88268937
120MP0005645_abnormal_hypothalamus_physiol0.88125965
121MP0002148_abnormal_hypersensitivity_rea0.87521466
122MP0002116_abnormal_craniofacial_bone0.86404497
123MP0001177_atelectasis0.86396520
124MP0002735_abnormal_chemical_nociception0.86107046
125MP0002733_abnormal_thermal_nociception0.86070530
126MP0004185_abnormal_adipocyte_glucose0.84378801
127MP0002066_abnormal_motor_capabilities/c0.82855111
128MP0008995_early_reproductive_senescence0.82704066
129MP0002234_abnormal_pharynx_morphology0.82444884
130MP0000613_abnormal_salivary_gland0.81436604
131MP0002928_abnormal_bile_duct0.80351621
132MP0001851_eye_inflammation0.80130738
133MP0002067_abnormal_sensory_capabilities0.78724029
134MP0005646_abnormal_pituitary_gland0.78626698
135MP0008872_abnormal_physiological_respon0.78300490
136MP0005410_abnormal_fertilization0.77221267
137MP0000534_abnormal_ureter_morphology0.77201552
138MP0005253_abnormal_eye_physiology0.76452328
139MP0003942_abnormal_urinary_system0.76190694
140MP0000230_abnormal_systemic_arterial0.75368474
141MP0001340_abnormal_eyelid_morphology0.75189466
142MP0005386_behavior/neurological_phenoty0.75184726
143MP0004924_abnormal_behavior0.75184726
144MP0008932_abnormal_embryonic_tissue0.74664299
145MP0002452_abnormal_antigen_presenting0.73394458
146MP0005503_abnormal_tendon_morphology0.73315947
147MP0005084_abnormal_gallbladder_morpholo0.73308957
148MP0002163_abnormal_gland_morphology0.72502795
149MP0002063_abnormal_learning/memory/cond0.72423481
150MP0001502_abnormal_circadian_rhythm0.72261019
151MP0001188_hyperpigmentation0.71606614
152MP0002420_abnormal_adaptive_immunity0.71564146
153MP0001440_abnormal_grooming_behavior0.71162611
154MP0001970_abnormal_pain_threshold0.71157767
155MP0001819_abnormal_immune_cell0.70959118
156MP0009745_abnormal_behavioral_response0.70672105
157MP0003283_abnormal_digestive_organ0.70670211
158MP0002557_abnormal_social/conspecific_i0.69143400
159MP0003635_abnormal_synaptic_transmissio0.68969487
160MP0002822_catalepsy0.66769419
161MP0009764_decreased_sensitivity_to0.65580592
162MP0001119_abnormal_female_reproductive0.65138897

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.25873409
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.25873409
3Short 1st metacarpal (HP:0010034)5.19298213
4Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)5.19298213
5Sensory axonal neuropathy (HP:0003390)5.16217983
6Parakeratosis (HP:0001036)4.94321862
7Abnormality of the 1st metacarpal (HP:0010009)4.56185476
8Cerebral hypomyelination (HP:0006808)4.05902996
9Peripheral hypomyelination (HP:0007182)3.72128268
10Abnormality of the corticospinal tract (HP:0002492)3.60078209
11Pendular nystagmus (HP:0012043)3.54097853
12Anomalous pulmonary venous return (HP:0010772)3.49362873
13Alacrima (HP:0000522)3.46179524
14Short phalanx of the thumb (HP:0009660)3.33975766
15Fused cervical vertebrae (HP:0002949)3.31254141
16Adrenal hypoplasia (HP:0000835)3.29980544
17Absent rod-and cone-mediated responses on ERG (HP:0007688)3.25129256
18Premature skin wrinkling (HP:0100678)3.24554151
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.21211302
20Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.17960259
21Small epiphyses (HP:0010585)3.16826668
22Abnormality of the pulmonary veins (HP:0011718)3.12027788
23Symphalangism affecting the phalanges of the hand (HP:0009773)3.11447502
24Aplasia/Hypoplasia of the hallux (HP:0008362)3.11380066
25Abnormality of the proximal phalanges of the hand (HP:0009834)3.10227700
26Akinesia (HP:0002304)3.10202406
27Abnormality of the phalanges of the 5th finger (HP:0004213)3.08728770
28Short hallux (HP:0010109)3.07845875
29Neurofibrillary tangles (HP:0002185)3.06944665
30Maternal diabetes (HP:0009800)3.05936139
31Carpal bone hypoplasia (HP:0001498)3.02066428
32Morphological abnormality of the middle ear (HP:0008609)2.99185505
33Absent thumb (HP:0009777)2.99007063
34Septo-optic dysplasia (HP:0100842)2.98942735
35Abnormality of the nasal septum (HP:0000419)2.97549056
36Chin dimple (HP:0010751)2.96977599
37Abnormality of the parathyroid morphology (HP:0011766)2.90350627
38Congenital stationary night blindness (HP:0007642)2.89713993
39Hypoplastic pelvis (HP:0008839)2.88492716
40Absent septum pellucidum (HP:0001331)2.88437326
41Abolished electroretinogram (ERG) (HP:0000550)2.86778619
42Abnormality of the middle phalanges of the toes (HP:0010183)2.86036838
43Acute necrotizing encephalopathy (HP:0006965)2.85890222
44Abnormality of the renal collecting system (HP:0004742)2.84031045
45Synostosis of carpal bones (HP:0005048)2.80113368
46Oligomenorrhea (HP:0000876)2.78867175
47Decreased lacrimation (HP:0000633)2.76467600
48Cupped ear (HP:0000378)2.72467765
49Abnormality of DNA repair (HP:0003254)2.71227510
50Humeroradial synostosis (HP:0003041)2.70160861
51Synostosis involving the elbow (HP:0003938)2.70160861
52Morphological abnormality of the inner ear (HP:0011390)2.69622819
53Abnormal rod and cone electroretinograms (HP:0008323)2.68459780
54Abnormality of the septum pellucidum (HP:0007375)2.66441869
55Ectopic kidney (HP:0000086)2.63188511
56Esophageal atresia (HP:0002032)2.61330655
57Anteriorly placed anus (HP:0001545)2.60825775
58Increased serum pyruvate (HP:0003542)2.59066061
59Abnormality of glycolysis (HP:0004366)2.59066061
60Pancreatic cysts (HP:0001737)2.58110846
61Abnormal mitochondria in muscle tissue (HP:0008316)2.55639679
62Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.54977758
63Congenital sensorineural hearing impairment (HP:0008527)2.51299582
64White forelock (HP:0002211)2.50379008
65Pancreatic fibrosis (HP:0100732)2.49498938
66Abnormal auditory evoked potentials (HP:0006958)2.46081053
67Spastic gait (HP:0002064)2.45411653
68Abnormality of midbrain morphology (HP:0002418)2.44343947
69Molar tooth sign on MRI (HP:0002419)2.44343947
70Reticulocytopenia (HP:0001896)2.43630224
71Patchy hypopigmentation of hair (HP:0011365)2.41329329
72Absent phalangeal crease (HP:0006109)2.38714012
73True hermaphroditism (HP:0010459)2.38047017
74Nephronophthisis (HP:0000090)2.36815744
75Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.36771451
76Agitation (HP:0000713)2.36754995
77Leukodystrophy (HP:0002415)2.36480888
78Spastic paraparesis (HP:0002313)2.35580501
79Type II lissencephaly (HP:0007260)2.32999345
80Coronal craniosynostosis (HP:0004440)2.30991364
81Progressive macrocephaly (HP:0004481)2.28967217
82Split foot (HP:0001839)2.27275429
83Severe muscular hypotonia (HP:0006829)2.26713901
84Porencephaly (HP:0002132)2.24743780
85Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.23637165
86Decreased subcutaneous fat (HP:0001002)2.20769384
873-Methylglutaconic aciduria (HP:0003535)2.17708739
88Aplasia/Hypoplasia involving the musculature (HP:0001460)2.17401322
89Fetal akinesia sequence (HP:0001989)2.12908768
90Conical tooth (HP:0000698)2.12188558
91IgG deficiency (HP:0004315)2.11378494
92Decreased electroretinogram (ERG) amplitude (HP:0000654)2.11304815
93Acute encephalopathy (HP:0006846)2.10641720
94Thyroid-stimulating hormone excess (HP:0002925)2.09026647
95Onion bulb formation (HP:0003383)2.07711389
96Renal Fanconi syndrome (HP:0001994)2.07673587
97Abnormality of the costochondral junction (HP:0000919)2.07492489
98Hypoplasia of the capital femoral epiphysis (HP:0003090)2.05301337
99Genetic anticipation (HP:0003743)2.05038069
100Carpal synostosis (HP:0009702)2.04299292
101Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03937466
102Congenital malformation of the right heart (HP:0011723)2.03577052
103Double outlet right ventricle (HP:0001719)2.03577052
104Congenital ichthyosiform erythroderma (HP:0007431)2.03177150
105Vaginal atresia (HP:0000148)2.02923878
106Toxemia of pregnancy (HP:0100603)1.99741632
107Mitochondrial inheritance (HP:0001427)1.99694834
108Thickened helices (HP:0000391)1.99538114
109Abnormality of the phalanges of the 2nd finger (HP:0009541)1.98924486
110Retinal dysplasia (HP:0007973)1.98245368
111Barrel-shaped chest (HP:0001552)1.96801167
112Meningocele (HP:0002435)1.96717995
113Dynein arm defect of respiratory motile cilia (HP:0012255)1.96614386
114Absent/shortened dynein arms (HP:0200106)1.96614386
115Horseshoe kidney (HP:0000085)1.96413586
116Optic nerve coloboma (HP:0000588)1.95761265
117Bowel incontinence (HP:0002607)1.94703560
118Genital tract atresia (HP:0001827)1.93964861
119Myelomeningocele (HP:0002475)1.93412415
120Chorioretinal atrophy (HP:0000533)1.93403597
121Asplenia (HP:0001746)1.93177470
122Concave nail (HP:0001598)1.93161916
123Abnormality of cells of the erythroid lineage (HP:0012130)1.92175701
124Osteomalacia (HP:0002749)1.92165176
125Abnormal finger flexion creases (HP:0006143)1.91896888
126Hypoplasia of the iris (HP:0007676)1.91207052
127Stenosis of the external auditory canal (HP:0000402)1.90533958
128Decreased central vision (HP:0007663)1.89169049
129Absent hand (HP:0004050)1.89115567
130Partial duplication of thumb phalanx (HP:0009944)1.89028918
131Attenuation of retinal blood vessels (HP:0007843)1.88913233
132Prominent occiput (HP:0000269)1.88749135
133Sclerocornea (HP:0000647)1.88614128
134Irregular epiphyses (HP:0010582)1.87801696
135Esotropia (HP:0000565)1.86507030
136Synostosis involving bones of the hand (HP:0004278)1.86260450
137Bifid scrotum (HP:0000048)1.85871016
138Optic disc pallor (HP:0000543)1.85724240
139Methylmalonic acidemia (HP:0002912)1.85685324
140Abnormality of the renal medulla (HP:0100957)1.85206551
141Stridor (HP:0010307)1.85006061
142Abnormality of incisor morphology (HP:0011063)1.84827565
143Short femoral neck (HP:0100864)1.84658638
144Increased corneal curvature (HP:0100692)1.84583037
145Keratoconus (HP:0000563)1.84583037
146Abnormal large intestine physiology (HP:0012700)1.83798872
147Delayed epiphyseal ossification (HP:0002663)1.83352064
148Bony spicule pigmentary retinopathy (HP:0007737)1.83142848
149Pallor (HP:0000980)1.83069958
150Short thumb (HP:0009778)1.81884902
151Intention tremor (HP:0002080)1.81299607
152Abnormal number of erythroid precursors (HP:0012131)1.80380128
153Hypoplasia of the ulna (HP:0003022)1.79881128
154Aplasia/Hypoplasia of the spleen (HP:0010451)1.79845348
155Overfolded helix (HP:0000396)1.79174514
156Hypoplasia of the uterus (HP:0000013)1.78805061
157CNS hypomyelination (HP:0003429)1.78780394
158Hypomagnesemia (HP:0002917)1.78421673
159Abnormality of the fetal cardiovascular system (HP:0010948)1.78343195
160Abnormal umbilical cord blood vessels (HP:0011403)1.78343195
161Single umbilical artery (HP:0001195)1.78343195
162Stomatitis (HP:0010280)1.77598857
163Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77544766
164Absent epiphyses (HP:0010577)1.77544766
165Hypoplastic left heart (HP:0004383)1.77282496
166Partial duplication of the phalanx of hand (HP:0009999)1.76873123
167Leukocytosis (HP:0001974)1.75662243
168Partial agenesis of the corpus callosum (HP:0001338)1.75147860
169Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.74833135
170Poor speech (HP:0002465)1.73940442
171Septate vagina (HP:0001153)1.73928152
172Anencephaly (HP:0002323)1.73745521
173Abnormal respiratory motile cilium morphology (HP:0005938)1.73551823
174Abnormal respiratory epithelium morphology (HP:0012253)1.73551823
175Gastrointestinal atresia (HP:0002589)1.73068082
176Nasolacrimal duct obstruction (HP:0000579)1.72845298
177Intestinal atresia (HP:0011100)1.71173020
178Vitreoretinal degeneration (HP:0000655)1.70761184
179Round ear (HP:0100830)1.70575255
180Duplicated collecting system (HP:0000081)1.70145109
181Pulmonary artery stenosis (HP:0004415)1.68513064
182Abnormally folded helix (HP:0008544)1.67700665
183Aplasia of the musculature (HP:0100854)1.67547098
184Mixed hearing impairment (HP:0000410)1.67488681
185Optic nerve hypoplasia (HP:0000609)1.67241356
186Severe visual impairment (HP:0001141)1.67057791
187Intellectual disability, moderate (HP:0002342)1.66659827
188Aplasia/hypoplasia of the uterus (HP:0008684)1.66556368
189Atelectasis (HP:0100750)1.66366091
190Nonprogressive disorder (HP:0003680)1.65998639
191Medial flaring of the eyebrow (HP:0010747)1.65787624
192Vertebral fusion (HP:0002948)1.65775166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.48213672
2TNIK4.57526735
3OXSR13.71075471
4TXK3.64922556
5GRK13.29291776
6BCR3.23988364
7PRPF4B3.14483536
8EPHB13.02435095
9TAOK32.89016117
10BCKDK2.68133763
11PKN12.32161304
12FGFR22.29900145
13ICK2.27185487
14IRAK22.09198521
15NEK62.05376261
16CDK192.03758950
17DYRK22.01311122
18TYRO32.00864899
19MAPK131.90365416
20UHMK11.89456835
21MAP4K21.82327460
22IRAK11.81008362
23CSNK1G31.78703346
24MAP4K11.74274231
25TIE11.73654034
26IRAK41.70784908
27CASK1.68288886
28KIT1.64079896
29MKNK11.62119170
30CSNK1A1L1.56221930
31FRK1.55607936
32ZAK1.50373490
33WNK41.48806096
34CDK91.47669684
35CLK11.44949033
36ROCK21.43238694
37EPHB21.42234036
38MUSK1.36157947
39SYK1.34629924
40PINK11.34286824
41MET1.33543939
42PRKD21.32460909
43CSNK1G11.31631715
44MAP2K71.30182212
45LIMK11.26552110
46TLK11.21570328
47MAP2K21.17743115
48BMPR1B1.14104329
49GRK61.11576342
50CSNK1G21.06655223
51WNK11.06531900
52PBK1.05155742
53AURKA1.04901579
54RPS6KA61.04742664
55MST41.04533475
56MKNK21.03807761
57STK161.00772736
58MAP3K90.98748287
59MAP3K40.98630710
60MAP3K110.98475797
61MARK10.98462849
62SRPK10.97457085
63MATK0.96803509
64INSRR0.94855261
65DYRK1B0.94168870
66LCK0.93818223
67MAPKAPK50.91605625
68MAP2K10.90476616
69LYN0.90260934
70MARK30.88701716
71FES0.87735308
72RPS6KA20.87266852
73PIM10.87082141
74WNK30.85832400
75RPS6KC10.84859464
76RPS6KL10.84859464
77EPHA30.84219744
78FGR0.84088265
79STK110.83958527
80NUAK10.83625684
81PNCK0.82194856
82SIK20.80631915
83KDR0.79231501
84TEC0.78731328
85PLK20.76696153
86MAP3K130.75992836
87BTK0.75103817
88PHKG10.74032274
89PHKG20.74032274
90PRKCH0.73291310
91PRKCQ0.70787052
92BRD40.70488244
93PRKACA0.70390652
94ROCK10.69740327
95MAPK150.68819931
96ADRBK20.68457699
97PRKCG0.68261039
98BMPR20.67235031
99CAMKK10.66812734
100NTRK20.66702104
101MELK0.66198835
102NLK0.65981680
103TNK20.65948339
104FLT30.65920750
105SGK2230.65359771
106SGK4940.65359771
107PIK3CA0.64425309
108YES10.61454849
109CAMK10.60827684
110CAMK2B0.60059748
111ADRBK10.59587764
112PAK30.58695886
113PRKCZ0.57085667
114PIM20.54022743
115RPS6KA50.53711937
116RPS6KA10.53487292
117CHUK0.53102570
118MAP3K70.52697564
119ERBB40.51508339
120HCK0.51027118
121VRK10.50181119
122MARK20.49845143
123GRK50.49364763
124SGK20.49336648
125CAMK2D0.48367805
126MAPK40.48065039
127DAPK20.47888615
128CDK30.47089759
129CDK140.46995843
130SIK30.46813286
131TESK20.46370005
132TBK10.45529798
133OBSCN0.44691544
134NTRK10.43441057
135KSR10.43034180
136PAK60.41167906
137GRK70.40310541
138EIF2AK20.37556941
139PDGFRB0.37399404
140CDK180.37258263
141FYN0.36546548
142IKBKE0.36253803
143DYRK30.35684325
144PRKCE0.34658763
145CSF1R0.33707267
146ITK0.33683922
147LATS10.33470993
148CDK11A0.32652968
149CDK150.32284533
150CDK50.31840275
151CSNK1D0.31639332
152PAK10.31146009
153DMPK0.31069129
154CAMK2A0.29225121
155DYRK1A0.27474649
156CSK0.27005345
157BUB10.26517287
158IKBKB0.25353232
159INSR0.24973263
160CSNK1A10.24863222
161GSK3A0.24565888
162CDK80.23154790

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.55298109
2Steroid biosynthesis_Homo sapiens_hsa001004.60736913
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.68170564
4Fatty acid elongation_Homo sapiens_hsa000623.18681208
5Ether lipid metabolism_Homo sapiens_hsa005653.02321871
6Axon guidance_Homo sapiens_hsa043602.85004857
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.61442001
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.53944055
9Graft-versus-host disease_Homo sapiens_hsa053322.10616640
10Protein export_Homo sapiens_hsa030602.06895925
11Asthma_Homo sapiens_hsa053102.05830768
12RNA polymerase_Homo sapiens_hsa030201.99552155
13Nicotine addiction_Homo sapiens_hsa050331.93753399
14Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.85129839
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.83507359
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78980074
17Oxidative phosphorylation_Homo sapiens_hsa001901.78401989
18Type I diabetes mellitus_Homo sapiens_hsa049401.77193126
19Sphingolipid metabolism_Homo sapiens_hsa006001.67538111
20Basal transcription factors_Homo sapiens_hsa030221.60593918
21Morphine addiction_Homo sapiens_hsa050321.56742976
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.47941516
23Vitamin B6 metabolism_Homo sapiens_hsa007501.45589152
24Sulfur relay system_Homo sapiens_hsa041221.41853579
25Basal cell carcinoma_Homo sapiens_hsa052171.39820819
26Linoleic acid metabolism_Homo sapiens_hsa005911.36844580
27Hematopoietic cell lineage_Homo sapiens_hsa046401.34942148
28Notch signaling pathway_Homo sapiens_hsa043301.31249811
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30466161
30RNA degradation_Homo sapiens_hsa030181.30284057
31Olfactory transduction_Homo sapiens_hsa047401.25282180
32Hedgehog signaling pathway_Homo sapiens_hsa043401.25155551
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.22269820
34Renal cell carcinoma_Homo sapiens_hsa052111.18267475
35Parkinsons disease_Homo sapiens_hsa050121.17107481
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13789624
37Alzheimers disease_Homo sapiens_hsa050101.08446244
38Arachidonic acid metabolism_Homo sapiens_hsa005901.06581090
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06350778
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02316865
41Serotonergic synapse_Homo sapiens_hsa047261.01058642
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00557248
43Nitrogen metabolism_Homo sapiens_hsa009101.00164768
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95958618
45Tight junction_Homo sapiens_hsa045300.95468611
46Hippo signaling pathway_Homo sapiens_hsa043900.87918114
47Proteasome_Homo sapiens_hsa030500.87023142
48Taste transduction_Homo sapiens_hsa047420.86588874
49GABAergic synapse_Homo sapiens_hsa047270.86487061
50Staphylococcus aureus infection_Homo sapiens_hsa051500.85690814
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.84853349
52Huntingtons disease_Homo sapiens_hsa050160.84640479
53Autoimmune thyroid disease_Homo sapiens_hsa053200.84606351
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83924071
55Malaria_Homo sapiens_hsa051440.82804771
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82129374
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.81452510
58Wnt signaling pathway_Homo sapiens_hsa043100.80989183
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79351639
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.77551683
61Caffeine metabolism_Homo sapiens_hsa002320.77012160
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76940642
63Butanoate metabolism_Homo sapiens_hsa006500.76606378
64Circadian entrainment_Homo sapiens_hsa047130.75543329
65ECM-receptor interaction_Homo sapiens_hsa045120.75423670
66Non-homologous end-joining_Homo sapiens_hsa034500.75112494
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74865801
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74694185
69Ovarian steroidogenesis_Homo sapiens_hsa049130.74453918
70Choline metabolism in cancer_Homo sapiens_hsa052310.73997698
71Glycerolipid metabolism_Homo sapiens_hsa005610.72940603
72Ras signaling pathway_Homo sapiens_hsa040140.72918792
73MicroRNAs in cancer_Homo sapiens_hsa052060.72763478
74Shigellosis_Homo sapiens_hsa051310.72400564
75Rheumatoid arthritis_Homo sapiens_hsa053230.72088350
76T cell receptor signaling pathway_Homo sapiens_hsa046600.70828307
77Long-term depression_Homo sapiens_hsa047300.70245333
78Spliceosome_Homo sapiens_hsa030400.69960578
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69544213
80Sulfur metabolism_Homo sapiens_hsa009200.68958119
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68714078
82Dorso-ventral axis formation_Homo sapiens_hsa043200.67250571
83Glutamatergic synapse_Homo sapiens_hsa047240.67168936
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66040638
85Antigen processing and presentation_Homo sapiens_hsa046120.63840731
86Phototransduction_Homo sapiens_hsa047440.63094860
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62769568
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62376128
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60978977
90Chemical carcinogenesis_Homo sapiens_hsa052040.60977710
91TGF-beta signaling pathway_Homo sapiens_hsa043500.60484829
92Vibrio cholerae infection_Homo sapiens_hsa051100.59039813
93ErbB signaling pathway_Homo sapiens_hsa040120.58483115
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58182073
95Endocytosis_Homo sapiens_hsa041440.58037259
96Leishmaniasis_Homo sapiens_hsa051400.57510795
97Fat digestion and absorption_Homo sapiens_hsa049750.57224737
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55907804
99Systemic lupus erythematosus_Homo sapiens_hsa053220.55416714
100Retinol metabolism_Homo sapiens_hsa008300.55271687
101Osteoclast differentiation_Homo sapiens_hsa043800.54466132
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.53901357
103Peroxisome_Homo sapiens_hsa041460.53492429
104Arginine and proline metabolism_Homo sapiens_hsa003300.53254055
105Prostate cancer_Homo sapiens_hsa052150.52844733
106African trypanosomiasis_Homo sapiens_hsa051430.52540461
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51177111
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51135250
109Tryptophan metabolism_Homo sapiens_hsa003800.50985852
110Insulin secretion_Homo sapiens_hsa049110.46852353
111Herpes simplex infection_Homo sapiens_hsa051680.46408889
112Chemokine signaling pathway_Homo sapiens_hsa040620.46349724
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45301452
114Selenocompound metabolism_Homo sapiens_hsa004500.44611990
115Cell cycle_Homo sapiens_hsa041100.44126980
116Regulation of autophagy_Homo sapiens_hsa041400.44078244
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43759184
118Calcium signaling pathway_Homo sapiens_hsa040200.43239468
119Type II diabetes mellitus_Homo sapiens_hsa049300.43125460
120B cell receptor signaling pathway_Homo sapiens_hsa046620.42389693
121Glutathione metabolism_Homo sapiens_hsa004800.41782719
122Ribosome_Homo sapiens_hsa030100.41487724
123Homologous recombination_Homo sapiens_hsa034400.40572401
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40522764
125Epstein-Barr virus infection_Homo sapiens_hsa051690.40404597
126Cardiac muscle contraction_Homo sapiens_hsa042600.39989220
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.38793204
128Fanconi anemia pathway_Homo sapiens_hsa034600.37737783
129Oxytocin signaling pathway_Homo sapiens_hsa049210.37720060
130Phagosome_Homo sapiens_hsa041450.37685888
131Pathways in cancer_Homo sapiens_hsa052000.36006675
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34809814
133Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33378821
134Collecting duct acid secretion_Homo sapiens_hsa049660.33260977
135cAMP signaling pathway_Homo sapiens_hsa040240.32823552
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32615905
137Cholinergic synapse_Homo sapiens_hsa047250.32592507
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.32523436
139Dopaminergic synapse_Homo sapiens_hsa047280.30825536
140Allograft rejection_Homo sapiens_hsa053300.30773063
141Primary immunodeficiency_Homo sapiens_hsa053400.30557864
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30159681
143Focal adhesion_Homo sapiens_hsa045100.29041458
144Viral myocarditis_Homo sapiens_hsa054160.29007241
145Leukocyte transendothelial migration_Homo sapiens_hsa046700.27636875
146Purine metabolism_Homo sapiens_hsa002300.26558903
147MAPK signaling pathway_Homo sapiens_hsa040100.26080847
148Metabolic pathways_Homo sapiens_hsa011000.25528750
149Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25328087
150Gap junction_Homo sapiens_hsa045400.24934313
151Salmonella infection_Homo sapiens_hsa051320.23555211

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