RNF123

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)6.74551883
2muscle filament sliding (GO:0030049)6.74551883
3sarcoplasmic reticulum calcium ion transport (GO:0070296)5.93309044
4skeletal muscle contraction (GO:0003009)5.92444922
5creatine metabolic process (GO:0006600)5.87555367
6protoporphyrinogen IX metabolic process (GO:0046501)5.81567119
7actin-mediated cell contraction (GO:0070252)5.39089615
8regulation of skeletal muscle contraction (GO:0014819)5.26732365
9protoporphyrinogen IX biosynthetic process (GO:0006782)5.22672274
10lysine metabolic process (GO:0006553)4.93094584
11lysine catabolic process (GO:0006554)4.93094584
12negative regulation of erythrocyte differentiation (GO:0045647)4.84943393
13oxygen transport (GO:0015671)4.82555305
14L-phenylalanine catabolic process (GO:0006559)4.56559222
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.56559222
16L-phenylalanine metabolic process (GO:0006558)4.40694398
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.40694398
18response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.39711859
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.33451662
20striated muscle contraction (GO:0006941)4.32906875
21porphyrin-containing compound biosynthetic process (GO:0006779)4.32762936
22actin filament-based movement (GO:0030048)4.31279377
23kynurenine metabolic process (GO:0070189)4.28662204
24myofibril assembly (GO:0030239)4.28308293
25gas transport (GO:0015669)4.27018958
26alpha-linolenic acid metabolic process (GO:0036109)4.22903770
272-oxoglutarate metabolic process (GO:0006103)4.16961422
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.14171318
29aromatic amino acid family catabolic process (GO:0009074)4.12112758
30dicarboxylic acid biosynthetic process (GO:0043650)4.11086320
31NADH metabolic process (GO:0006734)4.08265225
32skeletal muscle adaptation (GO:0043501)3.96444102
33glyoxylate metabolic process (GO:0046487)3.92266793
34tetrapyrrole biosynthetic process (GO:0033014)3.92205930
35mannose metabolic process (GO:0006013)3.84630406
36cysteine metabolic process (GO:0006534)3.83114075
37indolalkylamine catabolic process (GO:0046218)3.79850679
38tryptophan catabolic process (GO:0006569)3.79850679
39indole-containing compound catabolic process (GO:0042436)3.79850679
40glycogen catabolic process (GO:0005980)3.78499760
41aspartate family amino acid catabolic process (GO:0009068)3.72633065
42regulation of cholesterol homeostasis (GO:2000188)3.71319888
43urea cycle (GO:0000050)3.70427491
44urea metabolic process (GO:0019627)3.70427491
45response to muscle activity (GO:0014850)3.69601955
46sarcomere organization (GO:0045214)3.68669295
47bile acid biosynthetic process (GO:0006699)3.68543261
48glucan catabolic process (GO:0009251)3.67014534
49heme biosynthetic process (GO:0006783)3.66756764
50positive regulation of myotube differentiation (GO:0010831)3.66450616
51plasma lipoprotein particle assembly (GO:0034377)3.64986847
52porphyrin-containing compound metabolic process (GO:0006778)3.63876906
53skeletal muscle fiber development (GO:0048741)3.63084683
54regulation of relaxation of muscle (GO:1901077)3.62857144
55carnitine shuttle (GO:0006853)3.61786448
56amino-acid betaine metabolic process (GO:0006577)3.58532188
57fatty acid transmembrane transport (GO:1902001)3.58125856
58negative regulation of fibrinolysis (GO:0051918)3.57434518
59positive regulation of fatty acid beta-oxidation (GO:0032000)3.56244747
60tryptophan metabolic process (GO:0006568)3.53092652
61cardiac muscle contraction (GO:0060048)3.52895924
62positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.52424475
63high-density lipoprotein particle remodeling (GO:0034375)3.51431475
64cellular polysaccharide catabolic process (GO:0044247)3.49356669
65negative regulation of cell size (GO:0045792)3.49345401
66regulation of triglyceride catabolic process (GO:0010896)3.48736293
67regulation of fatty acid beta-oxidation (GO:0031998)3.46921539
68protein-lipid complex assembly (GO:0065005)3.45581036
69erythrocyte development (GO:0048821)3.45455638
70regulation of protein activation cascade (GO:2000257)3.44828986
71cellular ketone body metabolic process (GO:0046950)3.43369655
72response to mercury ion (GO:0046689)3.42010509
733-UTR-mediated mRNA stabilization (GO:0070935)3.41606203
74complement activation, alternative pathway (GO:0006957)3.39993867
75valine metabolic process (GO:0006573)3.39113934
76regulation of response to osmotic stress (GO:0047484)3.38476904
77phospholipid efflux (GO:0033700)3.37873954
78nitrogen cycle metabolic process (GO:0071941)3.35375647
79glutamate metabolic process (GO:0006536)3.34775590
80phospholipid homeostasis (GO:0055091)3.34400480
81cardiac myofibril assembly (GO:0055003)3.32921905
82oxaloacetate metabolic process (GO:0006107)3.31789236
83ethanol oxidation (GO:0006069)3.31726315
84response to methylmercury (GO:0051597)3.28849809
85sulfur amino acid catabolic process (GO:0000098)3.26172406
86regulation of fibrinolysis (GO:0051917)3.26011450
87plasma membrane repair (GO:0001778)3.23395582
88negative regulation of necroptotic process (GO:0060546)3.22264951
89intracellular estrogen receptor signaling pathway (GO:0030520)3.21737150
90polysaccharide catabolic process (GO:0000272)3.21254881
91regulation of complement activation (GO:0030449)3.20930311
92protein carboxylation (GO:0018214)3.18351117
93peptidyl-glutamic acid carboxylation (GO:0017187)3.18351117
94fructose metabolic process (GO:0006000)3.17573465
95striated muscle adaptation (GO:0014888)3.17562676
96response to inactivity (GO:0014854)3.17237123
97bile acid metabolic process (GO:0008206)3.17221308
98carnitine transmembrane transport (GO:1902603)3.16153749
99positive regulation of lipid catabolic process (GO:0050996)3.15996332
100negative regulation of sterol transport (GO:0032372)3.15782314
101negative regulation of cholesterol transport (GO:0032375)3.15782314
102muscle contraction (GO:0006936)3.14873944
103fatty acid beta-oxidation (GO:0006635)3.14512510
104short-chain fatty acid metabolic process (GO:0046459)3.14285447
105negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.11875958
106heme metabolic process (GO:0042168)3.11076331
107regulation of fatty acid oxidation (GO:0046320)3.10298748
108acetyl-CoA metabolic process (GO:0006084)3.10249278
109amino-acid betaine transport (GO:0015838)3.09697727
110carnitine transport (GO:0015879)3.09697727
111carnitine metabolic process (GO:0009437)3.09691839
112cardiac muscle hypertrophy (GO:0003300)3.08099872
113regulation of cholesterol esterification (GO:0010872)3.08017756
114alpha-amino acid catabolic process (GO:1901606)3.07296997
115serine family amino acid catabolic process (GO:0009071)3.07268979
116very-low-density lipoprotein particle assembly (GO:0034379)3.06722020
117triglyceride homeostasis (GO:0070328)3.06289039
118acylglycerol homeostasis (GO:0055090)3.06289039
119reverse cholesterol transport (GO:0043691)3.05876558
120tricarboxylic acid metabolic process (GO:0072350)3.05790180
121positive regulation of lipoprotein lipase activity (GO:0051006)3.05677575
122positive regulation of triglyceride lipase activity (GO:0061365)3.05677575
123positive regulation of fatty acid oxidation (GO:0046321)3.02462824
124plasma lipoprotein particle remodeling (GO:0034369)3.00542508
125protein-lipid complex remodeling (GO:0034368)3.00542508
126macromolecular complex remodeling (GO:0034367)3.00542508
127antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.98938551
128antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.98938551
129cholesterol efflux (GO:0033344)2.96328048
130erythrocyte maturation (GO:0043249)2.96034222
131myotube cell development (GO:0014904)2.95977906
132fatty acid oxidation (GO:0019395)2.95360872
133ketone body metabolic process (GO:1902224)2.94837763
134regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.94553363
135hemoglobin metabolic process (GO:0020027)2.92669589
136regulation of gamma-delta T cell differentiation (GO:0045586)2.92002398
137actomyosin structure organization (GO:0031032)2.91350166
138striated muscle hypertrophy (GO:0014897)2.91113892
139cellular modified amino acid catabolic process (GO:0042219)2.89064271
140lipid oxidation (GO:0034440)2.88425778
141fatty acid catabolic process (GO:0009062)2.88325338
142plasma lipoprotein particle organization (GO:0071827)2.87218060
143cellular hyperosmotic response (GO:0071474)2.86035413
144focal adhesion assembly (GO:0048041)2.85154293
145cell-substrate adherens junction assembly (GO:0007045)2.85154293
146plasma lipoprotein particle clearance (GO:0034381)2.85111400
147monocarboxylic acid catabolic process (GO:0072329)2.85084954
148regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.84844255
149negative regulation of fatty acid biosynthetic process (GO:0045717)2.84243890
150regulation of necroptotic process (GO:0060544)2.83765044
151gluconeogenesis (GO:0006094)2.82876735
152muscle system process (GO:0003012)2.82305966
153striated muscle atrophy (GO:0014891)2.81847635
154cellular amino acid catabolic process (GO:0009063)2.81519787
155complement activation, classical pathway (GO:0006958)2.81289858
156protein-lipid complex subunit organization (GO:0071825)2.80967511
157homocysteine metabolic process (GO:0050667)2.80758926
158aromatic amino acid family metabolic process (GO:0009072)2.79530741
159positive regulation of triglyceride metabolic process (GO:0090208)2.79022556
160regulation of fatty acid biosynthetic process (GO:0042304)2.76548238
161negative regulation of potassium ion transmembrane transport (GO:1901380)2.74416234
162glycogen metabolic process (GO:0005977)2.73500093
163muscle hypertrophy in response to stress (GO:0003299)2.71991198
164cardiac muscle adaptation (GO:0014887)2.71991198
165cardiac muscle hypertrophy in response to stress (GO:0014898)2.71991198
166glucan metabolic process (GO:0044042)2.71613099
167cellular glucan metabolic process (GO:0006073)2.71613099
168glycogen biosynthetic process (GO:0005978)2.69866918
169glucan biosynthetic process (GO:0009250)2.69866918
170muscle adaptation (GO:0043500)2.68768113
171negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.68690766
172negative regulation of cell killing (GO:0031342)2.68690766
173hexose biosynthetic process (GO:0019319)2.67272119
174muscle hypertrophy (GO:0014896)2.66773670
175regulation of myotube differentiation (GO:0010830)2.61905093
176regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.60465037
177embryonic process involved in female pregnancy (GO:0060136)2.60072810
178monosaccharide biosynthetic process (GO:0046364)2.57700838
179protein targeting to plasma membrane (GO:0072661)2.54361391
180regulation of gamma-delta T cell activation (GO:0046643)2.52208797
181regulation of NFAT protein import into nucleus (GO:0051532)2.51690122
182negative regulation of necrotic cell death (GO:0060547)2.51299235

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.59121940
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.65398372
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.30535139
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.66584108
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.41762601
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.13839055
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.96767888
8GATA1_22025678_ChIP-Seq_K562_Human2.89062676
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.78218757
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.72448108
11GATA1_19941826_ChIP-Seq_K562_Human2.62439019
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.51107793
13* GATA1_19941827_ChIP-Seq_MEL_Mouse2.47249233
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.30793145
15MYC_22102868_ChIP-Seq_BL_Human2.22774957
16TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.17142180
17LXR_22292898_ChIP-Seq_THP-1_Human2.03149492
18KDM2B_26808549_Chip-Seq_SUP-B15_Human1.95402379
19KDM2B_26808549_Chip-Seq_DND41_Human1.94685680
20SCL_19346495_ChIP-Seq_HPC-7_Human1.93743780
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.91067828
22TCF7_22412390_ChIP-Seq_EML_Mouse1.86998260
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.81035103
24VDR_21846776_ChIP-Seq_THP-1_Human1.79245858
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77211846
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.75700426
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74670125
28GATA2_19941826_ChIP-Seq_K562_Human1.71014900
29TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.67178415
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66687557
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65304114
32ZNF263_19887448_ChIP-Seq_K562_Human1.62764450
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59100533
34MAF_26560356_Chip-Seq_TH1_Human1.56244593
35* TET1_21451524_ChIP-Seq_MESCs_Mouse1.52681528
36KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.52632334
37FOXA2_19822575_ChIP-Seq_HepG2_Human1.51456491
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50995936
39UTX_26944678_Chip-Seq_JUKART_Human1.49970112
40GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47440835
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.46049634
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.43178120
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42989097
44DROSHA_22980978_ChIP-Seq_HELA_Human1.42543071
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42346036
46KDM2B_26808549_Chip-Seq_K562_Human1.41814407
47RUNX_20019798_ChIP-Seq_JUKART_Human1.40243326
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.38578559
49* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.37620643
50SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36785474
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.32891142
52GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32120199
53ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29877647
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29709651
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28947514
56PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28757443
57EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28242424
58* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27324623
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25770995
60* P68_20966046_ChIP-Seq_HELA_Human1.25715639
61MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.24285682
62TBX20_22328084_ChIP-Seq_HEART_Mouse1.23330733
63TBX20_22080862_ChIP-Seq_HEART_Mouse1.23330733
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22046606
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21002834
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19616959
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19160814
68UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18790199
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18705845
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18550169
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.18060611
72PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17647877
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17387619
74GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15652230
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15628267
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15223341
77PHF8_20622854_ChIP-Seq_HELA_Human1.15034987
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13653703
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13598133
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13238752
81BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11908779
82SA1_27219007_Chip-Seq_Bcells_Human1.11753160
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11149511
84BCL6_27268052_Chip-Seq_Bcells_Human1.09214290
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08995107
86* E2F1_20622854_ChIP-Seq_HELA_Human1.08692426
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07394626
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06881156
89SPI1_23127762_ChIP-Seq_K562_Human1.06868905
90NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06725580
91CREB1_26743006_Chip-Seq_LNCaP_Human1.06079373
92CTCF_26484167_Chip-Seq_Bcells_Mouse1.06042850
93BCOR_27268052_Chip-Seq_Bcells_Human1.05854304
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04900330
95CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04097132
96SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03991025
97SMC4_20622854_ChIP-Seq_HELA_Human1.03535425
98RACK7_27058665_Chip-Seq_MCF-7_Human1.02916295
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02738644
100MAF_26560356_Chip-Seq_TH2_Human1.02215542
101* ELF1_20517297_ChIP-Seq_JURKAT_Human1.01363237
102NCOR1_26117541_ChIP-Seq_K562_Human1.00255649
103CLOCK_20551151_ChIP-Seq_293T_Human1.00041280
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98917785
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97585698
106CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97180021
107VDR_24763502_ChIP-Seq_THP-1_Human0.96813017
108* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96202502
109CTCF_27219007_Chip-Seq_Bcells_Human0.94545476
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94192788
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92680719
112LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91349691
113HNF4A_19822575_ChIP-Seq_HepG2_Human0.90683963
114SPI1_20517297_ChIP-Seq_HL60_Human0.90593349
115* RARB_27405468_Chip-Seq_BRAIN_Mouse0.89834246
116GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88821416
117MYB_26560356_Chip-Seq_TH1_Human0.88523989
118FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.87957614
119ESR2_21235772_ChIP-Seq_MCF-7_Human0.87931097
120TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87083529
121SA1_27219007_Chip-Seq_ERYTHROID_Human0.85635525
122NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85247141
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84448106
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83306881
125CTCF_21964334_Chip-Seq_Bcells_Human0.82740509
126RUNX1_22412390_ChIP-Seq_EML_Mouse0.82197066
127P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81161936
128DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81149735
129EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.80506874

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.22584738
2MP0005360_urolithiasis4.93068826
3MP0005451_abnormal_body_composition4.76908339
4MP0003656_abnormal_erythrocyte_physiolo4.55802676
5MP0005365_abnormal_bile_salt4.16023739
6MP0005085_abnormal_gallbladder_physiolo3.92761085
7MP0005083_abnormal_biliary_tract3.37919197
8MP0008875_abnormal_xenobiotic_pharmacok3.04799144
9MP0004147_increased_porphyrin_level2.95417715
10MP0003252_abnormal_bile_duct2.88524759
11MP0002837_dystrophic_cardiac_calcinosis2.70800122
12MP0003646_muscle_fatigue2.65413357
13MP0010329_abnormal_lipoprotein_level2.59387780
14MP0009840_abnormal_foam_cell2.25868911
15MP0004130_abnormal_muscle_cell2.16907868
16MP0008260_abnormal_autophagy2.01886660
17MP0000750_abnormal_muscle_regeneration2.00628418
18MP0005058_abnormal_lysosome_morphology1.96137896
19MP0000751_myopathy1.96046103
20MP0003191_abnormal_cellular_cholesterol1.93362071
21MP0003806_abnormal_nucleotide_metabolis1.88950347
22MP0000609_abnormal_liver_physiology1.85097607
23MP0000749_muscle_degeneration1.82029079
24MP0001666_abnormal_nutrient_absorption1.77154931
25MP0000733_abnormal_muscle_development1.72763780
26MP0004036_abnormal_muscle_relaxation1.64683168
27MP0005332_abnormal_amino_acid1.62189677
28MP0002118_abnormal_lipid_homeostasis1.61981440
29MP0002138_abnormal_hepatobiliary_system1.60333656
30MP0004215_abnormal_myocardial_fiber1.59097330
31MP0003172_abnormal_lysosome_physiology1.58267119
32MP0009278_abnormal_bone_marrow1.52149539
33MP0001661_extended_life_span1.50504607
34MP0005319_abnormal_enzyme/_coenzyme1.47465439
35MP0005584_abnormal_enzyme/coenzyme_acti1.45290315
36MP0005330_cardiomyopathy1.44720221
37MP0008961_abnormal_basal_metabolism1.40724063
38MP0004084_abnormal_cardiac_muscle1.40658294
39MP0002269_muscular_atrophy1.38833660
40MP0006036_abnormal_mitochondrial_physio1.38363179
41MP0003300_gastrointestinal_ulcer1.37539474
42MP0004087_abnormal_muscle_fiber1.37276221
43MP0003436_decreased_susceptibility_to1.36901083
44MP0000747_muscle_weakness1.36508357
45MP0005670_abnormal_white_adipose1.36254066
46MP0003868_abnormal_feces_composition1.34680051
47MP0003705_abnormal_hypodermis_morpholog1.32843146
48MP0006138_congestive_heart_failure1.29950980
49MP0003195_calcinosis1.28705260
50MP0004145_abnormal_muscle_electrophysio1.26476497
51MP0000685_abnormal_immune_system1.25102191
52MP0003221_abnormal_cardiomyocyte_apopto1.23526931
53MP0002822_catalepsy1.22785234
54MP0008775_abnormal_heart_ventricle1.21311285
55MP0005076_abnormal_cell_differentiation1.15756068
56MP0005666_abnormal_adipose_tissue1.14808004
57MP0002108_abnormal_muscle_morphology1.13170215
58MP0000604_amyloidosis1.11936490
59MP0003828_pulmonary_edema1.11550408
60MP0005636_abnormal_mineral_homeostasis1.09995271
61MP0004510_myositis1.09494824
62MP0003329_amyloid_beta_deposits1.08148190
63MP0003011_delayed_dark_adaptation1.05671562
64MP0005620_abnormal_muscle_contractility1.04248825
65MP0009643_abnormal_urine_homeostasis1.04026023
66MP0005409_darkened_coat_color1.02173144
67MP0003879_abnormal_hair_cell1.02062479
68MP0000013_abnormal_adipose_tissue1.00200506
69MP0004858_abnormal_nervous_system1.00149181
70MP0002909_abnormal_adrenal_gland0.99870735
71MP0010630_abnormal_cardiac_muscle0.99182850
72MP0002078_abnormal_glucose_homeostasis0.98074078
73MP0001849_ear_inflammation0.98038435
74MP0004233_abnormal_muscle_weight0.97417678
75MP0001764_abnormal_homeostasis0.97114926
76MP0002971_abnormal_brown_adipose0.96878075
77MP0005266_abnormal_metabolism0.95886213
78MP0003303_peritoneal_inflammation0.95067424
79MP0005535_abnormal_body_temperature0.95054024
80MP0000759_abnormal_skeletal_muscle0.93632474
81MP0004859_abnormal_synaptic_plasticity0.92422748
82MP0000598_abnormal_liver_morphology0.92280797
83MP0005551_abnormal_eye_electrophysiolog0.91802377
84MP0002972_abnormal_cardiac_muscle0.91214970
85MP0009764_decreased_sensitivity_to0.90452698
86MP0005464_abnormal_platelet_physiology0.87673928
87MP0003045_fibrosis0.87017241
88MP0004019_abnormal_vitamin_homeostasis0.86334478
89MP0002106_abnormal_muscle_physiology0.86308935
90MP0004484_altered_response_of0.86265183
91MP0008874_decreased_physiological_sensi0.86026684
92MP0005334_abnormal_fat_pad0.85883642
93MP0004185_abnormal_adipocyte_glucose0.84140073
94MP0005375_adipose_tissue_phenotype0.83228557
95MP0005387_immune_system_phenotype0.81585504
96MP0001790_abnormal_immune_system0.81585504
97MP0002166_altered_tumor_susceptibility0.81583764
98MP0002127_abnormal_cardiovascular_syste0.81578972
99MP0001544_abnormal_cardiovascular_syste0.80009085
100MP0005385_cardiovascular_system_phenoty0.80009085
101MP0009763_increased_sensitivity_to0.79227589
102MP0006035_abnormal_mitochondrial_morpho0.78935030
103MP0003763_abnormal_thymus_physiology0.75610160
104MP0008569_lethality_at_weaning0.75391651
105MP0004085_abnormal_heartbeat0.75272816
106MP0001800_abnormal_humoral_immune0.73099466
107MP0003566_abnormal_cell_adhesion0.72976288
108MP0002332_abnormal_exercise_endurance0.72229247
109MP0009642_abnormal_blood_homeostasis0.72212762
110MP0008469_abnormal_protein_level0.71594760
111MP0001765_abnormal_ion_homeostasis0.71395468
112MP0008872_abnormal_physiological_respon0.70083190
113MP0003137_abnormal_impulse_conducting0.70023603
114MP0010368_abnormal_lymphatic_system0.69179017
115MP0005025_abnormal_response_to0.67917767
116MP0002419_abnormal_innate_immunity0.67692628
117MP0004947_skin_inflammation0.67072658
118MP0002398_abnormal_bone_marrow0.64703971
119MP0008438_abnormal_cutaneous_collagen0.64429433
120MP0000003_abnormal_adipose_tissue0.63656764
121MP0002928_abnormal_bile_duct0.63112491
122MP0000689_abnormal_spleen_morphology0.62778565
123MP0003075_altered_response_to0.62636094
124MP0004381_abnormal_hair_follicle0.62052894
125MP0001545_abnormal_hematopoietic_system0.61895978
126MP0005397_hematopoietic_system_phenotyp0.61895978
127MP0002132_abnormal_respiratory_system0.60848483
128MP0009333_abnormal_splenocyte_physiolog0.59405567
129MP0001915_intracranial_hemorrhage0.57735983
130MP0004270_analgesia0.57572084
131MP0005369_muscle_phenotype0.56713803
132MP0002722_abnormal_immune_system0.55968084
133MP0003866_abnormal_defecation0.55858760
134MP0003091_abnormal_cell_migration0.54631834
135MP0000266_abnormal_heart_morphology0.52699088
136MP0000858_altered_metastatic_potential0.52604691
137MP0002249_abnormal_larynx_morphology0.50999728
138MP0005166_decreased_susceptibility_to0.50779092
139MP0009931_abnormal_skin_appearance0.49588831
140MP0002396_abnormal_hematopoietic_system0.48708716
141MP0000678_abnormal_parathyroid_gland0.48566389

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.49645639
2Nemaline bodies (HP:0003798)7.28809135
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.19018889
4Type 1 muscle fiber predominance (HP:0003803)6.03241320
5Myopathic facies (HP:0002058)5.75020444
6Poikilocytosis (HP:0004447)5.68798027
7Centrally nucleated skeletal muscle fibers (HP:0003687)4.61691931
8Deep venous thrombosis (HP:0002625)4.57468449
9Reticulocytosis (HP:0001923)4.43871798
10Cholelithiasis (HP:0001081)4.37373930
11Acanthocytosis (HP:0001927)4.17883830
12EMG: myopathic abnormalities (HP:0003458)4.10192307
13Abnormality of skeletal muscle fiber size (HP:0012084)4.05413282
14Muscle fiber splitting (HP:0003555)4.02797029
15Abnormality of the heme biosynthetic pathway (HP:0010472)3.98704574
16Abnormal gallbladder morphology (HP:0012437)3.97434918
17Ulnar deviation of the wrist (HP:0003049)3.92439271
18Hypochromic microcytic anemia (HP:0004840)3.88425740
19Distal arthrogryposis (HP:0005684)3.88384983
20Exercise-induced myalgia (HP:0003738)3.85435637
21Hyperbilirubinemia (HP:0002904)3.80148270
22Round ear (HP:0100830)3.79677475
23Xanthomatosis (HP:0000991)3.72698394
24Increased variability in muscle fiber diameter (HP:0003557)3.71730479
25Abnormality of aromatic amino acid family metabolism (HP:0004338)3.59833972
26Intrahepatic cholestasis (HP:0001406)3.54525200
27Ketosis (HP:0001946)3.45167672
28Distal lower limb muscle weakness (HP:0009053)3.39088324
29Myoglobinuria (HP:0002913)3.33001171
30Hyperlipoproteinemia (HP:0010980)3.32595959
31Abnormality of monocarboxylic acid metabolism (HP:0010996)3.24330104
32Neck muscle weakness (HP:0000467)3.18331319
33Distal lower limb amyotrophy (HP:0008944)3.16945343
34Complement deficiency (HP:0004431)3.11559968
35Abnormal gallbladder physiology (HP:0012438)3.09892853
36Cholecystitis (HP:0001082)3.09892853
37Ketoacidosis (HP:0001993)3.02709635
38Exercise-induced muscle cramps (HP:0003710)3.00157158
39Hyperammonemia (HP:0001987)2.98922834
40Hypoalphalipoproteinemia (HP:0003233)2.97296920
41Hypobetalipoproteinemia (HP:0003563)2.92122115
42Hypoglycemic coma (HP:0001325)2.91293122
43Dysmetric saccades (HP:0000641)2.90590822
44Abnormality of the calf musculature (HP:0001430)2.89935680
45Sudden death (HP:0001699)2.86944128
46Abnormality of the gallbladder (HP:0005264)2.79204921
47Rimmed vacuoles (HP:0003805)2.77723496
48Prolonged partial thromboplastin time (HP:0003645)2.76529638
49Hypolipoproteinemia (HP:0010981)2.73730614
50Calcaneovalgus deformity (HP:0001848)2.69999354
51Malignant hyperthermia (HP:0002047)2.60681005
52Difficulty climbing stairs (HP:0003551)2.60440305
53EMG: neuropathic changes (HP:0003445)2.58277981
54Insomnia (HP:0100785)2.57435986
55Hyporeflexia of lower limbs (HP:0002600)2.55490709
56Abnormality of the common coagulation pathway (HP:0010990)2.53844778
57Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.50644121
58Asymmetric septal hypertrophy (HP:0001670)2.49419025
59Abnormality of fatty-acid metabolism (HP:0004359)2.48146638
60Abnormality of sulfur amino acid metabolism (HP:0004339)2.45898151
61Polycythemia (HP:0001901)2.45172727
62Spinal rigidity (HP:0003306)2.44598772
63Hepatocellular carcinoma (HP:0001402)2.43564656
64Mildly elevated creatine phosphokinase (HP:0008180)2.42710021
65Bulbar palsy (HP:0001283)2.42460845
66Joint hemorrhage (HP:0005261)2.42320716
67Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.38235910
68Gout (HP:0001997)2.37937303
69Frequent falls (HP:0002359)2.36347058
70Metabolic acidosis (HP:0001942)2.33555086
71Epidermoid cyst (HP:0200040)2.31438214
72Lower limb amyotrophy (HP:0007210)2.29497658
73Progressive muscle weakness (HP:0003323)2.27987219
74Abnormality of the calcaneus (HP:0008364)2.26995319
75Deformed tarsal bones (HP:0008119)2.25873773
76Rhabdomyolysis (HP:0003201)2.25583145
77Generalized muscle weakness (HP:0003324)2.25191239
78Difficulty running (HP:0009046)2.24018264
79Hypercholesterolemia (HP:0003124)2.23954819
80Central scotoma (HP:0000603)2.22688225
81Calf muscle hypertrophy (HP:0008981)2.20197281
82Hyperglycinuria (HP:0003108)2.14977135
83Abnormality of complement system (HP:0005339)2.13570460
84Hemorrhage of the eye (HP:0011885)2.13297145
85Abnormality of glutamine family amino acid metabolism (HP:0010902)2.13256326
86Scapular winging (HP:0003691)2.12353767
87Global brain atrophy (HP:0002283)2.11458247
88Muscle hypertrophy of the lower extremities (HP:0008968)2.10325711
89Abnormality of the lower motor neuron (HP:0002366)2.09944560
90Bundle branch block (HP:0011710)2.08456434
91Myocardial infarction (HP:0001658)2.08031922
92Cerebral aneurysm (HP:0004944)2.07489894
93Areflexia of lower limbs (HP:0002522)2.05538906
94Abnormality of purine metabolism (HP:0004352)2.05217020
95Foot dorsiflexor weakness (HP:0009027)2.05037256
96Status epilepticus (HP:0002133)2.04942548
97Paralysis (HP:0003470)2.04888939
98Abnormality of glycine metabolism (HP:0010895)2.04804911
99Abnormality of serine family amino acid metabolism (HP:0010894)2.04804911
100Abnormality of aspartate family amino acid metabolism (HP:0010899)2.02015379
101Diaphragmatic weakness (HP:0009113)2.01616092
102Abnormality of reticulocytes (HP:0004312)2.01105056
103Hyperglycinemia (HP:0002154)1.99513167
104Neonatal onset (HP:0003623)1.98897981
105Abnormality of the fingertips (HP:0001211)1.98634649
106Slender build (HP:0001533)1.98148805
107Easy fatigability (HP:0003388)1.97792938
108Abnormality of the left ventricular outflow tract (HP:0011103)1.97741099
109Subaortic stenosis (HP:0001682)1.97741099
110Abnormality of the foot musculature (HP:0001436)1.97586876
111Mitral stenosis (HP:0001718)1.97231006
112Stridor (HP:0010307)1.96346397
113Achilles tendon contracture (HP:0001771)1.95265254
114Late onset (HP:0003584)1.95134130
115Hypochromic anemia (HP:0001931)1.92523618
116Generalized hyperpigmentation (HP:0007440)1.92505100
117Abnormality of the Achilles tendon (HP:0005109)1.91762576
118Papilloma (HP:0012740)1.91554733
119Verrucae (HP:0200043)1.91554733
120Atrioventricular block (HP:0001678)1.91026805
121Sensorimotor neuropathy (HP:0007141)1.90921320
122Increased connective tissue (HP:0009025)1.90341985
123Ventricular tachycardia (HP:0004756)1.89535993
124Abnormality of iron homeostasis (HP:0011031)1.86677427
125Delayed CNS myelination (HP:0002188)1.86162246
126Colitis (HP:0002583)1.85932826
127Ragged-red muscle fibers (HP:0003200)1.84623597
128Absent phalangeal crease (HP:0006109)1.83484285
129Dilated cardiomyopathy (HP:0001644)1.83000465
130Congenital stationary night blindness (HP:0007642)1.82191295
131Abnormality of the intrinsic pathway (HP:0010989)1.81961031
132Toxemia of pregnancy (HP:0100603)1.80650240
133Abnormality of methionine metabolism (HP:0010901)1.80458003
134Increased serum ferritin (HP:0003281)1.79205629
135Hyperinsulinemic hypoglycemia (HP:0000825)1.78165360
136Muscle stiffness (HP:0003552)1.78146049
137Death in childhood (HP:0003819)1.77544312
138Abnormality of nucleobase metabolism (HP:0010932)1.77482345
139Skin nodule (HP:0200036)1.77311693
140Heart block (HP:0012722)1.77012981
141Autoimmune thrombocytopenia (HP:0001973)1.75945840
142Abnormality of transition element cation homeostasis (HP:0011030)1.75479079
143Myotonia (HP:0002486)1.75193101
144Dicarboxylic aciduria (HP:0003215)1.74779220
145Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74779220
146Microcytic anemia (HP:0001935)1.73113614
147Abnormal atrioventricular conduction (HP:0005150)1.72476208
148Muscular dystrophy (HP:0003560)1.71470422
149Obstructive sleep apnea (HP:0002870)1.70010160
150Fatigue (HP:0012378)1.65096122
151Waddling gait (HP:0002515)1.60799877
152Gowers sign (HP:0003391)1.60377718
153Weak cry (HP:0001612)1.59187883
154Ankle clonus (HP:0011448)1.55889625
155Ulnar bowing (HP:0003031)1.55533153
156Limb-girdle muscle atrophy (HP:0003797)1.55060415
157Fetal akinesia sequence (HP:0001989)1.54845656
158Gastrointestinal infarctions (HP:0005244)1.54104155
159Eczematoid dermatitis (HP:0000976)1.52302773
160Lipoatrophy (HP:0100578)1.49594152
161Hyperkalemia (HP:0002153)1.48072232

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.59581410
2PRPF4B3.06255478
3PKN23.04812461
4MAP4K12.78328857
5MAP3K102.63996962
6TTN2.63413465
7SIK12.63351404
8ERN12.59222432
9BCKDK2.42529261
10FGFR42.40930985
11EEF2K2.16765153
12RIPK12.07106044
13SIK21.94234327
14MAP3K71.93502082
15TYK21.82226511
16TAOK11.67052920
17GRK61.66320289
18PHKG21.64827399
19PHKG11.64827399
20JAK11.54434621
21TAOK21.50511414
22SMG11.49169032
23PINK11.40929655
24MAPK111.40156807
25INSRR1.36139498
26MAP2K31.34836863
27TAOK31.32808521
28PTK61.31499213
29CAMK1G1.29996879
30TESK21.27176673
31SGK31.25635313
32PRKCH1.22404893
33FLT31.22248100
34JAK21.21963084
35DAPK21.21580600
36PIK3CG1.21512055
37MAP3K31.18826277
38OBSCN1.16873722
39MAPK121.16071906
40ICK1.14899504
41IRAK31.13932801
42MAP2K41.13059642
43PRKAA11.09129903
44LMTK21.08749385
45RIPK41.07710657
46CAMK1D1.07038522
47NEK11.02699197
48DMPK1.00768534
49STK380.99982713
50MAP3K130.99644471
51ZAP700.97331414
52CDK120.96458428
53PDK10.94131140
54SYK0.92763612
55STK40.89285121
56MAP3K60.89131466
57PRKAA20.86426043
58JAK30.86244182
59CDC42BPA0.86096322
60CAMKK10.85634220
61BLK0.83438377
62STK100.81474300
63RET0.81363335
64FGFR30.81162990
65TBK10.80014320
66ITK0.79814270
67MAPKAPK30.79630382
68PDK40.77821621
69PDK30.77821621
70PDPK10.77243595
71IKBKE0.76482950
72DYRK1B0.75418984
73PRKD30.74836194
74SGK20.74198637
75MARK20.72122146
76TNK20.69883803
77MAP2K60.69480601
78TRPM70.68535469
79EPHB10.67837103
80RPS6KL10.67664598
81RPS6KC10.67664598
82TGFBR20.66564228
83PAK60.65944860
84MAP3K40.64671596
85BMX0.64465960
86MUSK0.64420886
87MAPK70.63703667
88MAP2K20.63487722
89MTOR0.61068933
90FES0.60428458
91CSF1R0.60034759
92PRKD10.59220264
93KIT0.59139385
94MAP2K10.57863166
95MAP3K110.57621815
96CAMK40.53713805
97MAP3K140.53372614
98ARAF0.53131832
99ERBB20.51637878
100LRRK20.50956928
101RPS6KA60.50821634
102AKT20.50688048
103PRKD20.50578228
104HCK0.50051093
105SGK10.49028271
106MAP3K10.48740270
107KSR20.48702422
108CSK0.47305281
109KDR0.47230180
110RAF10.46954964
111BTK0.46448771
112STK110.45458744
113WNK10.45211648
114PRKACG0.45020917
115CDK60.44762492
116SGK2230.43742280
117SGK4940.43742280
118MOS0.43433355
119MARK30.43406431
120PIK3CA0.43319019
121PRKCQ0.43140376
122MAP3K50.42803701
123MAPK40.41759373
124EPHA30.41685533
125HIPK20.41639160
126LCK0.41242425
127IRAK40.41131158
128CDK40.39615359
129RPS6KA30.39458577
130FGR0.39373273
131RPS6KA20.38828560
132PDGFRA0.36942012
133PTK2B0.33217109
134RPS6KA10.31962934
135MAPK100.30793011

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.06922943
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.36778453
3Nitrogen metabolism_Homo sapiens_hsa009103.28358834
4Arginine biosynthesis_Homo sapiens_hsa002202.73332724
5Fatty acid degradation_Homo sapiens_hsa000712.63791464
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.46023301
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.34711694
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.33375205
9Other glycan degradation_Homo sapiens_hsa005112.33368066
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.25668865
11Tryptophan metabolism_Homo sapiens_hsa003802.13177395
12Propanoate metabolism_Homo sapiens_hsa006402.01936966
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98930224
14ABC transporters_Homo sapiens_hsa020101.86358892
15PPAR signaling pathway_Homo sapiens_hsa033201.84574123
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.84370063
17Complement and coagulation cascades_Homo sapiens_hsa046101.80696267
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.78109541
19Fatty acid metabolism_Homo sapiens_hsa012121.76689884
20Bile secretion_Homo sapiens_hsa049761.75786161
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.72259843
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.68126991
23Butanoate metabolism_Homo sapiens_hsa006501.64455336
24Lysine degradation_Homo sapiens_hsa003101.60236121
25Caffeine metabolism_Homo sapiens_hsa002321.57728493
26Pyruvate metabolism_Homo sapiens_hsa006201.52494225
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.48973727
28Carbon metabolism_Homo sapiens_hsa012001.40874596
29beta-Alanine metabolism_Homo sapiens_hsa004101.34586747
30Peroxisome_Homo sapiens_hsa041461.33622936
31VEGF signaling pathway_Homo sapiens_hsa043701.33600229
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26163353
33GnRH signaling pathway_Homo sapiens_hsa049121.24863276
34Biosynthesis of amino acids_Homo sapiens_hsa012301.19999909
35Insulin resistance_Homo sapiens_hsa049311.17897913
36Starch and sucrose metabolism_Homo sapiens_hsa005001.14742260
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11451021
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08237090
39Staphylococcus aureus infection_Homo sapiens_hsa051501.08041251
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03150797
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02912229
42Selenocompound metabolism_Homo sapiens_hsa004501.01044107
43Galactose metabolism_Homo sapiens_hsa000521.00982394
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00860936
45Adipocytokine signaling pathway_Homo sapiens_hsa049200.98105770
46Circadian rhythm_Homo sapiens_hsa047100.98079551
47Glycerolipid metabolism_Homo sapiens_hsa005610.96621513
48Neurotrophin signaling pathway_Homo sapiens_hsa047220.95820280
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.95504612
50Pancreatic cancer_Homo sapiens_hsa052120.95014988
51Sulfur relay system_Homo sapiens_hsa041220.94491764
52Malaria_Homo sapiens_hsa051440.94420416
53Fat digestion and absorption_Homo sapiens_hsa049750.93089859
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92455469
55Notch signaling pathway_Homo sapiens_hsa043300.90516070
56Endometrial cancer_Homo sapiens_hsa052130.90487878
57Type II diabetes mellitus_Homo sapiens_hsa049300.89983708
58Osteoclast differentiation_Homo sapiens_hsa043800.88276993
59Glucagon signaling pathway_Homo sapiens_hsa049220.88124194
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.87399118
61Prion diseases_Homo sapiens_hsa050200.86845962
62Glioma_Homo sapiens_hsa052140.86285662
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.86210141
64Long-term potentiation_Homo sapiens_hsa047200.84976557
65Vitamin B6 metabolism_Homo sapiens_hsa007500.84939502
66Phenylalanine metabolism_Homo sapiens_hsa003600.84115080
67FoxO signaling pathway_Homo sapiens_hsa040680.81125764
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79759334
69Bladder cancer_Homo sapiens_hsa052190.78257956
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73531757
71AMPK signaling pathway_Homo sapiens_hsa041520.73323282
72Chemical carcinogenesis_Homo sapiens_hsa052040.72578329
73Inositol phosphate metabolism_Homo sapiens_hsa005620.69810141
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69710708
75Insulin signaling pathway_Homo sapiens_hsa049100.69607630
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69257629
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.69033504
78Platelet activation_Homo sapiens_hsa046110.68296101
79ErbB signaling pathway_Homo sapiens_hsa040120.68044551
80Renal cell carcinoma_Homo sapiens_hsa052110.67034962
81Choline metabolism in cancer_Homo sapiens_hsa052310.65588044
82Focal adhesion_Homo sapiens_hsa045100.64474678
83Dilated cardiomyopathy_Homo sapiens_hsa054140.64035499
84Primary immunodeficiency_Homo sapiens_hsa053400.63834282
85Prolactin signaling pathway_Homo sapiens_hsa049170.63786180
86Calcium signaling pathway_Homo sapiens_hsa040200.63368388
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62764368
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62749605
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61949981
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61826521
91Amoebiasis_Homo sapiens_hsa051460.61708618
92Histidine metabolism_Homo sapiens_hsa003400.61586141
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61565490
94HIF-1 signaling pathway_Homo sapiens_hsa040660.61422262
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61373377
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61328676
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59627981
98Retinol metabolism_Homo sapiens_hsa008300.58673342
99B cell receptor signaling pathway_Homo sapiens_hsa046620.58284575
100Phototransduction_Homo sapiens_hsa047440.56765056
101Tyrosine metabolism_Homo sapiens_hsa003500.54536184
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54142973
103Hepatitis C_Homo sapiens_hsa051600.53980377
104Fatty acid biosynthesis_Homo sapiens_hsa000610.53976755
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.53800710
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.53496495
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52109081
108Thyroid cancer_Homo sapiens_hsa052160.50898100
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50806051
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50248166
111Non-small cell lung cancer_Homo sapiens_hsa052230.49968786
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49856936
113Insulin secretion_Homo sapiens_hsa049110.48499603
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.48186011
115Pentose phosphate pathway_Homo sapiens_hsa000300.47621528
116Fructose and mannose metabolism_Homo sapiens_hsa000510.47462492
117Systemic lupus erythematosus_Homo sapiens_hsa053220.45877609
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45470438
119mTOR signaling pathway_Homo sapiens_hsa041500.44723735
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43883138
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43138317
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.41797098
123T cell receptor signaling pathway_Homo sapiens_hsa046600.38716047
124Acute myeloid leukemia_Homo sapiens_hsa052210.37056729
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.36361699
126Gastric acid secretion_Homo sapiens_hsa049710.34614994
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34008192
128Arginine and proline metabolism_Homo sapiens_hsa003300.33237699
129Oxytocin signaling pathway_Homo sapiens_hsa049210.32658682
130Cardiac muscle contraction_Homo sapiens_hsa042600.32605873
131Olfactory transduction_Homo sapiens_hsa047400.32154870
132Salivary secretion_Homo sapiens_hsa049700.31335171
133Circadian entrainment_Homo sapiens_hsa047130.28908315
134GABAergic synapse_Homo sapiens_hsa047270.28639777
135Dorso-ventral axis formation_Homo sapiens_hsa043200.28464744
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28280054
137Renin secretion_Homo sapiens_hsa049240.28242648
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27621091
139Maturity onset diabetes of the young_Homo sapiens_hsa049500.27448042
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27442264
141Chronic myeloid leukemia_Homo sapiens_hsa052200.22863644

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