RNF125

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.32546756
2L-phenylalanine catabolic process (GO:0006559)6.32546756
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.10049583
4L-phenylalanine metabolic process (GO:0006558)6.10049583
5aromatic amino acid family catabolic process (GO:0009074)5.96882497
6tryptophan catabolic process (GO:0006569)5.66713259
7indole-containing compound catabolic process (GO:0042436)5.66713259
8indolalkylamine catabolic process (GO:0046218)5.66713259
9kynurenine metabolic process (GO:0070189)5.44804092
10bile acid biosynthetic process (GO:0006699)5.38440308
11serine family amino acid catabolic process (GO:0009071)5.30843050
12tryptophan metabolic process (GO:0006568)5.30314397
13cysteine metabolic process (GO:0006534)5.22006659
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.20509315
15urea metabolic process (GO:0019627)5.06713208
16urea cycle (GO:0000050)5.06713208
17sulfur amino acid catabolic process (GO:0000098)5.04421391
18regulation of protein activation cascade (GO:2000257)5.03480423
19complement activation, alternative pathway (GO:0006957)5.02168046
20glycine metabolic process (GO:0006544)5.01732335
21negative T cell selection (GO:0043383)5.01367859
22glyoxylate metabolic process (GO:0046487)5.01342899
23alpha-linolenic acid metabolic process (GO:0036109)4.97571052
24DNA deamination (GO:0045006)4.87427983
25negative regulation of fibrinolysis (GO:0051918)4.86465642
26negative thymic T cell selection (GO:0045060)4.82463759
27regulation of complement activation (GO:0030449)4.73070331
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.70669435
29nitrogen cycle metabolic process (GO:0071941)4.67092074
30positive regulation of gamma-delta T cell activation (GO:0046645)4.65642347
31regulation of fibrinolysis (GO:0051917)4.63292922
32regulation of gamma-delta T cell differentiation (GO:0045586)4.61171790
33high-density lipoprotein particle remodeling (GO:0034375)4.54187933
34bile acid metabolic process (GO:0008206)4.54059814
35homocysteine metabolic process (GO:0050667)4.51429559
36protein carboxylation (GO:0018214)4.50070628
37peptidyl-glutamic acid carboxylation (GO:0017187)4.50070628
38positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.48849724
39aromatic amino acid family metabolic process (GO:0009072)4.48411554
40amino-acid betaine metabolic process (GO:0006577)4.45811039
41activated T cell proliferation (GO:0050798)4.43339085
42serine family amino acid metabolic process (GO:0009069)4.42298307
43regulation of B cell receptor signaling pathway (GO:0050855)4.41907748
44serine family amino acid biosynthetic process (GO:0009070)4.29532663
45imidazole-containing compound metabolic process (GO:0052803)4.28134001
46bile acid and bile salt transport (GO:0015721)4.27638283
47tolerance induction (GO:0002507)4.24141534
48regulation of triglyceride catabolic process (GO:0010896)4.22887505
49positive T cell selection (GO:0043368)4.22499446
50alpha-amino acid catabolic process (GO:1901606)4.19628630
51negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.19444486
52negative regulation of cell killing (GO:0031342)4.19444486
53regulation of gamma-delta T cell activation (GO:0046643)4.11399600
54cellular response to interleukin-15 (GO:0071350)4.08682742
55triglyceride homeostasis (GO:0070328)4.06775947
56acylglycerol homeostasis (GO:0055090)4.06775947
57interferon-gamma production (GO:0032609)4.04986756
58macromolecular complex remodeling (GO:0034367)3.98499056
59plasma lipoprotein particle remodeling (GO:0034369)3.98499056
60protein-lipid complex remodeling (GO:0034368)3.98499056
61response to interleukin-15 (GO:0070672)3.98118686
62amine catabolic process (GO:0009310)3.92246992
63cellular biogenic amine catabolic process (GO:0042402)3.92246992
64lysine metabolic process (GO:0006553)3.90198907
65lysine catabolic process (GO:0006554)3.90198907
66indolalkylamine metabolic process (GO:0006586)3.90192613
67blood coagulation, intrinsic pathway (GO:0007597)3.89855805
68reverse cholesterol transport (GO:0043691)3.87664173
69regulation of cholesterol esterification (GO:0010872)3.87246100
70positive thymic T cell selection (GO:0045059)3.86586466
71positive regulation of granulocyte differentiation (GO:0030854)3.85670709
72phospholipid efflux (GO:0033700)3.83874684
73tyrosine metabolic process (GO:0006570)3.83855506
74cellular amino acid catabolic process (GO:0009063)3.82785121
75L-fucose catabolic process (GO:0042355)3.77040059
76fucose catabolic process (GO:0019317)3.77040059
77L-fucose metabolic process (GO:0042354)3.77040059
78regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.71876701
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.71410614
80coenzyme catabolic process (GO:0009109)3.69606642
81negative regulation of cholesterol transport (GO:0032375)3.68584125
82negative regulation of sterol transport (GO:0032372)3.68584125
83cytolysis (GO:0019835)3.68344765
84benzene-containing compound metabolic process (GO:0042537)3.59612462
85urate metabolic process (GO:0046415)3.58952723
86regulation of alpha-beta T cell proliferation (GO:0046640)3.58448737
87ethanol oxidation (GO:0006069)3.56597521
88low-density lipoprotein particle remodeling (GO:0034374)3.53400337
89T cell selection (GO:0045058)3.52370415
90plasma lipoprotein particle assembly (GO:0034377)3.50882294
91plasma lipoprotein particle clearance (GO:0034381)3.50543148
92valine metabolic process (GO:0006573)3.49823429
93cytidine deamination (GO:0009972)3.49395883
94cytidine metabolic process (GO:0046087)3.49395883
95cytidine catabolic process (GO:0006216)3.49395883
96positive regulation of triglyceride lipase activity (GO:0061365)3.48498235
97positive regulation of lipoprotein lipase activity (GO:0051006)3.48498235
98NAD biosynthetic process (GO:0009435)3.47484986
99positive regulation of alpha-beta T cell proliferation (GO:0046641)3.47003113
100positive regulation of B cell differentiation (GO:0045579)3.46633819
101nicotinamide nucleotide biosynthetic process (GO:0019359)3.45703523
102pyridine nucleotide biosynthetic process (GO:0019363)3.45703523
103pantothenate metabolic process (GO:0015939)3.45149090
104complement activation, classical pathway (GO:0006958)3.43956302
105protein activation cascade (GO:0072376)3.43072286
106pyrimidine ribonucleoside catabolic process (GO:0046133)3.42789761
107complement activation (GO:0006956)3.41940642
108positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.41331226
109regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.41331226
110arginine metabolic process (GO:0006525)3.41150019
111organic acid catabolic process (GO:0016054)3.39963443
112carboxylic acid catabolic process (GO:0046395)3.39963443
113positive regulation of defense response to virus by host (GO:0002230)3.38740586
114cellular modified amino acid catabolic process (GO:0042219)3.38245438
115positive regulation of mRNA catabolic process (GO:0061014)3.37951417
116heme transport (GO:0015886)3.33935076
117negative regulation of T cell mediated immunity (GO:0002710)3.33833502
118cholesterol efflux (GO:0033344)3.33059522
119very-low-density lipoprotein particle assembly (GO:0034379)3.32937650
120glutamate metabolic process (GO:0006536)3.32930043
121cellular glucuronidation (GO:0052695)3.32907552
122cellular ketone body metabolic process (GO:0046950)3.32425954
123S-adenosylmethionine metabolic process (GO:0046500)3.31847264
124fibrinolysis (GO:0042730)3.31298576
125regulation of B cell differentiation (GO:0045577)3.31071745
126negative regulation of cAMP-mediated signaling (GO:0043951)3.30313932
127regulation of cholesterol homeostasis (GO:2000188)3.29931158
128thymic T cell selection (GO:0045061)3.28699497
129cholesterol homeostasis (GO:0042632)3.28564461
130L-serine metabolic process (GO:0006563)3.28160819
131alpha-beta T cell differentiation (GO:0046632)3.27603272
132mast cell activation (GO:0045576)3.26529374
133negative regulation of fatty acid biosynthetic process (GO:0045717)3.25789648
134folic acid metabolic process (GO:0046655)3.23918616
135sterol homeostasis (GO:0055092)3.21836884
1362-oxoglutarate metabolic process (GO:0006103)3.20345814
137cofactor catabolic process (GO:0051187)3.20222752
138mast cell activation involved in immune response (GO:0002279)3.16897476
139mast cell degranulation (GO:0043303)3.16897476
140antigen processing and presentation of endogenous antigen (GO:0019883)3.16067935
141carnitine metabolic process (GO:0009437)3.12879059
142sulfur amino acid metabolic process (GO:0000096)3.12299472
143fatty acid oxidation (GO:0019395)3.11214075
144pyridine-containing compound biosynthetic process (GO:0072525)3.10749437
145regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.09516764
146positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.09516764
147regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.08928319
148antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.08020228
149T cell migration (GO:0072678)3.03763602
150alpha-beta T cell activation (GO:0046631)3.00330732
151leukocyte aggregation (GO:0070486)3.00216610
152positive regulation of T cell differentiation in thymus (GO:0033089)2.99633469
153positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.91144194
154regulation of T cell mediated cytotoxicity (GO:0001914)2.90742241
155negative regulation of lymphocyte mediated immunity (GO:0002707)2.90633392
156Peyers patch development (GO:0048541)2.89512210
157mucosal-associated lymphoid tissue development (GO:0048537)2.89512210
158positive regulation of T cell mediated cytotoxicity (GO:0001916)2.88794918
159necroptotic process (GO:0070266)2.87712825
160protein K11-linked deubiquitination (GO:0035871)2.85120088
161purinergic nucleotide receptor signaling pathway (GO:0035590)2.84286397
162antigen receptor-mediated signaling pathway (GO:0050851)2.82348710
163positive regulation of calcium-mediated signaling (GO:0050850)2.80778135
164behavioral response to nicotine (GO:0035095)2.80723119
165regulation of regulatory T cell differentiation (GO:0045589)2.80328387
166positive regulation of interleukin-17 production (GO:0032740)2.78779386
167regulation of mRNA catabolic process (GO:0061013)2.78031574
168regulation of granulocyte differentiation (GO:0030852)2.74195679
169T cell receptor signaling pathway (GO:0050852)2.73011877
170antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.72015991
171negative regulation of interleukin-1 beta production (GO:0032691)2.71498089
172negative regulation of translation, ncRNA-mediated (GO:0040033)2.71342470
173regulation of translation, ncRNA-mediated (GO:0045974)2.71342470
174negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.71342470
175T cell differentiation (GO:0030217)2.71014851
176negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.66633774
177regulation of leukocyte mediated cytotoxicity (GO:0001910)2.65214572
178B cell receptor signaling pathway (GO:0050853)2.64557682
179regulation of isotype switching to IgG isotypes (GO:0048302)2.64428952
180positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.63211843
181negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.62274711
182CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.61806355
183regulation of T cell receptor signaling pathway (GO:0050856)2.60058069
184neural tube formation (GO:0001841)2.59919425
185growth hormone receptor signaling pathway (GO:0060396)2.58896796
186rRNA catabolic process (GO:0016075)2.58617212
187interkinetic nuclear migration (GO:0022027)2.57180006
188T cell homeostasis (GO:0043029)2.55429015
189negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.54463175
190CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.53805734
191T-helper cell differentiation (GO:0042093)2.53805734
192regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.51443580
193regulation of natural killer cell mediated immunity (GO:0002715)2.51443580
194necrotic cell death (GO:0070265)2.50600495
195regulation of cell killing (GO:0031341)2.50085781
196regulation of defense response to virus by host (GO:0050691)2.50062042
197negative regulation of adaptive immune response (GO:0002820)2.49062964
198programmed necrotic cell death (GO:0097300)2.49059290
199cell wall macromolecule catabolic process (GO:0016998)2.48989210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.90830624
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.23489564
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.68290298
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.49465210
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.60246665
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.46405827
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.91398224
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.83049674
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.77736908
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.65171544
11* RUNX_20019798_ChIP-Seq_JUKART_Human3.07606831
12ZNF274_21170338_ChIP-Seq_K562_Hela3.00283947
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.46168518
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.44185009
15VDR_22108803_ChIP-Seq_LS180_Human2.24999427
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.14832192
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14472071
18GATA3_26560356_Chip-Seq_TH2_Human2.02179072
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98687069
20E2F7_22180533_ChIP-Seq_HELA_Human1.97902731
21GATA3_27048872_Chip-Seq_THYMUS_Human1.95318792
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94727594
23* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.92822300
24IGF1R_20145208_ChIP-Seq_DFB_Human1.85829181
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84139203
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82729487
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.79994084
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.73057141
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70406896
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.65679247
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.58654143
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54733306
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52635040
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.50584001
35GATA1_22025678_ChIP-Seq_K562_Human1.49794549
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47550297
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.46895945
38ER_23166858_ChIP-Seq_MCF-7_Human1.46050409
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.45447526
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.43388745
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.41950727
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39932309
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37756559
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37108187
45EWS_26573619_Chip-Seq_HEK293_Human1.36143236
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35913582
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.34905133
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34420657
49KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.33881752
50TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.33538428
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32937358
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.32628580
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32613277
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32410720
55TAF15_26573619_Chip-Seq_HEK293_Human1.29868097
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28679865
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28590343
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27717190
59GABP_17652178_ChIP-ChIP_JURKAT_Human1.25654758
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25434249
61* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.24827173
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23891204
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23882123
64TP53_22573176_ChIP-Seq_HFKS_Human1.23803179
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.23755750
66ZNF263_19887448_ChIP-Seq_K562_Human1.23430149
67GBX2_23144817_ChIP-Seq_PC3_Human1.23369790
68TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.23163630
69* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.22902187
70BCAT_22108803_ChIP-Seq_LS180_Human1.22787418
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21288729
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.20505109
73VDR_24787735_ChIP-Seq_THP-1_Human1.20310868
74GATA3_26560356_Chip-Seq_TH1_Human1.19925351
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.19553618
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19133529
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17950760
78P300_19829295_ChIP-Seq_ESCs_Human1.16815392
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16418129
80FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13852457
81EST1_17652178_ChIP-ChIP_JURKAT_Human1.11398660
82GATA3_21878914_ChIP-Seq_MCF-7_Human1.10701606
83AR_21909140_ChIP-Seq_LNCAP_Human1.10439778
84SMRT_27268052_Chip-Seq_Bcells_Human1.10407880
85RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10344538
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09871650
87E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09557404
88CLOCK_20551151_ChIP-Seq_293T_Human1.08123770
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07964597
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.07964597
91FUS_26573619_Chip-Seq_HEK293_Human1.06609957
92SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06301534
93SRF_21415370_ChIP-Seq_HL-1_Mouse1.06086602
94* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06043096
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06012017
96ETS1_20019798_ChIP-Seq_JURKAT_Human1.05793565
97FOXP3_21729870_ChIP-Seq_TREG_Human1.05788101
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05621999
99MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05436312
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04414256
101FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03871851
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03629948
103FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03406158
104CRX_20693478_ChIP-Seq_RETINA_Mouse1.03140177
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03136258
106* VDR_23849224_ChIP-Seq_CD4+_Human1.02123404
107SCL_19346495_ChIP-Seq_HPC-7_Human1.01954283
108HTT_18923047_ChIP-ChIP_STHdh_Human1.01694138
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01659165
110GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.01107102
111STAT3_23295773_ChIP-Seq_U87_Human1.00653300
112UTX_26944678_Chip-Seq_JUKART_Human1.00632189
113AR_20517297_ChIP-Seq_VCAP_Human1.00583488
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00071425
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00071425
116HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00049832
117FLI1_21867929_ChIP-Seq_TH2_Mouse0.98333594
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97326313
119CBP_20019798_ChIP-Seq_JUKART_Human0.97326313
120OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97303109
121SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96622372
122VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96588873
123HNF4A_19822575_ChIP-Seq_HepG2_Human0.96235779
124SOX2_19829295_ChIP-Seq_ESCs_Human0.95860769
125NANOG_19829295_ChIP-Seq_ESCs_Human0.95860769
126* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95476159
127SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95315550
128* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95312991
129CIITA_25753668_ChIP-Seq_RAJI_Human0.94354007
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94161094
131TCF4_23295773_ChIP-Seq_U87_Human0.93847572
132* MYB_26560356_Chip-Seq_TH1_Human0.90958372
133HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89942042
134GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89853191
135NELFA_20434984_ChIP-Seq_ESCs_Mouse0.86604906
136* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.84852407
137GABP_19822575_ChIP-Seq_HepG2_Human0.84147689
138TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83136228
139FOXM1_23109430_ChIP-Seq_U2OS_Human0.83073913
140GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80560247
141ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80413407
142SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79641683
143MYC_22102868_ChIP-Seq_BL_Human0.79468051
144RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.78355649
145NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.78053991
146RARB_24833708_ChIP-Seq_LIVER_Mouse0.78052777
147PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77164317
148SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.76341786
149* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76200074
150* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.75964207
151RARA_24833708_ChIP-Seq_LIVER_Mouse0.75124504
152E2F4_17652178_ChIP-ChIP_JURKAT_Human0.74890926
153STAT4_19710469_ChIP-ChIP_TH1__Mouse0.73590696
154IRF1_19129219_ChIP-ChIP_H3396_Human0.73363742
155STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.73330440
156PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.72944325
157* DCP1A_22483619_ChIP-Seq_HELA_Human0.71615584
158BRD4_27068464_Chip-Seq_AML-cells_Mouse0.71403541
159SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.71066072
160* XRN2_22483619_ChIP-Seq_HELA_Human0.70799551
161MYC_19079543_ChIP-ChIP_MESCs_Mouse0.69353379
162POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.69200136
163* MYB_26560356_Chip-Seq_TH2_Human0.67899481
164GATA4_25053715_ChIP-Seq_YYC3_Human0.67599068
165LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.66898207
166NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.66640408
167TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.66427166
168FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.66417628
169KDM5A_27292631_Chip-Seq_BREAST_Human0.66404690
170* FOXA2_19822575_ChIP-Seq_HepG2_Human0.66107140
171* SPI1_23547873_ChIP-Seq_NB4_Human0.65741894
172* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.65728976
173MAF_26560356_Chip-Seq_TH1_Human0.65710438
174MAF_26560356_Chip-Seq_TH2_Human0.62429447
175* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.62384180
176MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.62262295
177NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.62252339
178ZFX_18555785_ChIP-Seq_MESCs_Mouse0.61885973

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.94527476
2MP0005360_urolithiasis6.25323773
3MP0005085_abnormal_gallbladder_physiolo5.71398799
4MP0005365_abnormal_bile_salt5.69986608
5MP0008875_abnormal_xenobiotic_pharmacok4.12430416
6MP0003806_abnormal_nucleotide_metabolis4.05997065
7MP0003252_abnormal_bile_duct3.27976858
8MP0010329_abnormal_lipoprotein_level3.10014441
9MP0009840_abnormal_foam_cell3.07722928
10MP0005083_abnormal_biliary_tract2.43830699
11MP0008877_abnormal_DNA_methylation2.32945195
12MP0001666_abnormal_nutrient_absorption2.31917102
13MP0005332_abnormal_amino_acid2.28464040
14MP0005000_abnormal_immune_tolerance2.23009331
15MP0000609_abnormal_liver_physiology2.21436896
16MP0000569_abnormal_digit_pigmentation2.13170329
17MP0003191_abnormal_cellular_cholesterol2.08666783
18MP0005387_immune_system_phenotype2.00791521
19MP0001790_abnormal_immune_system2.00791521
20MP0002138_abnormal_hepatobiliary_system1.99227395
21MP0001986_abnormal_taste_sensitivity1.98126453
22MP0003868_abnormal_feces_composition1.91603004
23MP0004019_abnormal_vitamin_homeostasis1.88630674
24MP0001764_abnormal_homeostasis1.87253937
25MP0003195_calcinosis1.82526367
26MP0003646_muscle_fatigue1.80471851
27MP0002148_abnormal_hypersensitivity_rea1.80349278
28MP0005319_abnormal_enzyme/_coenzyme1.79225097
29MP0002118_abnormal_lipid_homeostasis1.78394776
30MP0000372_irregular_coat_pigmentation1.69912158
31MP0003787_abnormal_imprinting1.69529900
32MP0000703_abnormal_thymus_morphology1.69116951
33MP0003724_increased_susceptibility_to1.68591417
34MP0002009_preneoplasia1.68475396
35MP0008057_abnormal_DNA_replication1.64315426
36MP0002405_respiratory_system_inflammati1.64266715
37MP0003186_abnormal_redox_activity1.55031083
38MP0005451_abnormal_body_composition1.54937632
39MP0009697_abnormal_copulation1.48948224
40MP0003656_abnormal_erythrocyte_physiolo1.46413630
41MP0005174_abnormal_tail_pigmentation1.44551017
42MP0003866_abnormal_defecation1.42193424
43MP0001501_abnormal_sleep_pattern1.37751937
44MP0005584_abnormal_enzyme/coenzyme_acti1.34308112
45MP0008872_abnormal_physiological_respon1.33060391
46MP0000598_abnormal_liver_morphology1.31622057
47MP0005310_abnormal_salivary_gland1.31443369
48MP0002277_abnormal_respiratory_mucosa1.28383728
49MP0003718_maternal_effect1.28123614
50MP0008995_early_reproductive_senescence1.26720997
51MP0003693_abnormal_embryo_hatching1.21746314
52MP0002933_joint_inflammation1.20032401
53MP0002163_abnormal_gland_morphology1.19753679
54MP0005647_abnormal_sex_gland1.18488927
55MP0008469_abnormal_protein_level1.18339831
56MP0009643_abnormal_urine_homeostasis1.16721817
57MP0008961_abnormal_basal_metabolism1.15037550
58MP0005464_abnormal_platelet_physiology1.14883359
59MP0009763_increased_sensitivity_to1.14032467
60MP0003763_abnormal_thymus_physiology1.12587126
61MP0009764_decreased_sensitivity_to1.10326408
62MP0005075_abnormal_melanosome_morpholog1.08491334
63MP0005551_abnormal_eye_electrophysiolog1.08276556
64MP0001851_eye_inflammation1.06941046
65MP0004142_abnormal_muscle_tone1.05362505
66MP0002693_abnormal_pancreas_physiology1.03573180
67MP0006036_abnormal_mitochondrial_physio1.01115817
68MP0002102_abnormal_ear_morphology1.01036136
69MP0005671_abnormal_response_to1.01004534
70MP0003011_delayed_dark_adaptation1.00687716
71MP0001533_abnormal_skeleton_physiology0.99179781
72MP0009785_altered_susceptibility_to0.97818608
73MP0000015_abnormal_ear_pigmentation0.95707613
74MP0010368_abnormal_lymphatic_system0.95639509
75MP0002396_abnormal_hematopoietic_system0.95190826
76MP0005645_abnormal_hypothalamus_physiol0.93731696
77MP0004381_abnormal_hair_follicle0.93246929
78MP0003436_decreased_susceptibility_to0.92553564
79MP0001919_abnormal_reproductive_system0.92520144
80MP0005397_hematopoietic_system_phenotyp0.92188812
81MP0001545_abnormal_hematopoietic_system0.92188812
82MP0001661_extended_life_span0.92042228
83MP0005636_abnormal_mineral_homeostasis0.89665055
84MP0009765_abnormal_xenobiotic_induced0.89470975
85MP0005408_hypopigmentation0.89371377
86MP0005084_abnormal_gallbladder_morpholo0.88536468
87MP0009278_abnormal_bone_marrow0.88481860
88MP0002132_abnormal_respiratory_system0.88455289
89MP0000685_abnormal_immune_system0.88293853
90MP0009333_abnormal_splenocyte_physiolog0.88138107
91MP0002006_tumorigenesis0.87009741
92MP0001853_heart_inflammation0.86932320
93MP0004947_skin_inflammation0.84718945
94MP0001968_abnormal_touch/_nociception0.84082377
95MP0001800_abnormal_humoral_immune0.81081302
96MP0009642_abnormal_blood_homeostasis0.80745680
97MP0004147_increased_porphyrin_level0.79740808
98MP0002234_abnormal_pharynx_morphology0.78433329
99MP0005025_abnormal_response_to0.78159099
100MP0001845_abnormal_inflammatory_respons0.76924272
101MP0005379_endocrine/exocrine_gland_phen0.76881152
102MP0004484_altered_response_of0.76392144
103MP0001663_abnormal_digestive_system0.75813183
104MP0005220_abnormal_exocrine_pancreas0.75623897
105MP0005670_abnormal_white_adipose0.75465380
106MP0002166_altered_tumor_susceptibility0.75297034
107MP0005448_abnormal_energy_balance0.75210778
108MP0005389_reproductive_system_phenotype0.74539284
109MP0005376_homeostasis/metabolism_phenot0.74515364
110MP0006082_CNS_inflammation0.73496523
111MP0006035_abnormal_mitochondrial_morpho0.71844526
112MP0004742_abnormal_vestibular_system0.71826225
113MP0010155_abnormal_intestine_physiology0.70995288
114MP0000689_abnormal_spleen_morphology0.70660823
115MP0001835_abnormal_antigen_presentation0.70282214
116MP0004043_abnormal_pH_regulation0.68834160
117MP0005395_other_phenotype0.66968036
118MP0009115_abnormal_fat_cell0.66191462
119MP0009745_abnormal_behavioral_response0.65663184
120MP0005535_abnormal_body_temperature0.65142073
121MP0002723_abnormal_immune_serum0.64356938
122MP0002254_reproductive_system_inflammat0.64072569
123MP0000230_abnormal_systemic_arterial0.63577695
124MP0006292_abnormal_olfactory_placode0.62894272
125MP0000470_abnormal_stomach_morphology0.62751660
126MP0002722_abnormal_immune_system0.62597324
127MP0005334_abnormal_fat_pad0.59922472
128MP0002971_abnormal_brown_adipose0.58826607
129MP0000604_amyloidosis0.58814785
130MP0005266_abnormal_metabolism0.58687264
131MP0002419_abnormal_innate_immunity0.58417201
132MP0002796_impaired_skin_barrier0.58342474
133MP0002398_abnormal_bone_marrow0.58209071
134MP0008873_increased_physiological_sensi0.56269484
135MP0009379_abnormal_foot_pigmentation0.55694752
136MP0001756_abnormal_urination0.55446671
137MP0001873_stomach_inflammation0.54532986
138MP0000716_abnormal_immune_system0.54514127
139MP0004957_abnormal_blastocyst_morpholog0.54225004
140MP0002429_abnormal_blood_cell0.53193617
141MP0002136_abnormal_kidney_physiology0.52023476
142MP0002876_abnormal_thyroid_physiology0.51517945
143MP0002078_abnormal_glucose_homeostasis0.50161013
144MP0002420_abnormal_adaptive_immunity0.48075239
145MP0002452_abnormal_antigen_presenting0.48034409
146MP0001819_abnormal_immune_cell0.47489320
147MP0004782_abnormal_surfactant_physiolog0.47361642
148MP0002928_abnormal_bile_duct0.47277729
149MP0000465_gastrointestinal_hemorrhage0.47059338
150MP0004130_abnormal_muscle_cell0.47048962

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.72991865
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.31986902
3Deep venous thrombosis (HP:0002625)6.14016037
4Hypobetalipoproteinemia (HP:0003563)5.89993626
5Prolonged partial thromboplastin time (HP:0003645)5.86675583
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.86200026
7Xanthomatosis (HP:0000991)5.56688823
8Hyperglycinemia (HP:0002154)5.15920808
9Abnormal delayed hypersensitivity skin test (HP:0002963)5.10002439
10Hyperlipoproteinemia (HP:0010980)4.85354524
11Complement deficiency (HP:0004431)4.73391650
12Abnormality of T cell number (HP:0011839)4.54851772
13Stomatitis (HP:0010280)4.49756483
14Hyperglycinuria (HP:0003108)4.35999728
15Hyperammonemia (HP:0001987)4.28030764
16Joint hemorrhage (HP:0005261)4.26989595
17Abnormality of glycine metabolism (HP:0010895)4.25006468
18Abnormality of serine family amino acid metabolism (HP:0010894)4.25006468
19Hypolipoproteinemia (HP:0010981)4.24947925
20Autoimmune hemolytic anemia (HP:0001890)4.12227724
21Abnormality of the common coagulation pathway (HP:0010990)4.09243677
22Autoimmune thrombocytopenia (HP:0001973)4.01872174
23Fat malabsorption (HP:0002630)3.97301475
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.93435229
25Epidermoid cyst (HP:0200040)3.84834540
26Elevated erythrocyte sedimentation rate (HP:0003565)3.84356617
27Abnormality of methionine metabolism (HP:0010901)3.83911111
28Abnormality of sulfur amino acid metabolism (HP:0004339)3.77739743
29Abnormality of the intrinsic pathway (HP:0010989)3.67492280
30T lymphocytopenia (HP:0005403)3.65858467
31Abnormality of T cells (HP:0002843)3.65151357
32Abnormality of aspartate family amino acid metabolism (HP:0010899)3.64559668
33Stomach cancer (HP:0012126)3.63986197
34Abnormality of pyrimidine metabolism (HP:0004353)3.62925244
35Hypoglycemic coma (HP:0001325)3.60188662
36Panhypogammaglobulinemia (HP:0003139)3.55565227
37Abnormality of serum amino acid levels (HP:0003112)3.47572167
38Hypoalphalipoproteinemia (HP:0003233)3.45634675
39Abnormality of glutamine family amino acid metabolism (HP:0010902)3.43385349
40Abnormality of complement system (HP:0005339)3.42407297
41Ketosis (HP:0001946)3.41410839
42Abnormality of T cell physiology (HP:0011840)3.38828621
43Eosinophilia (HP:0001880)3.38564314
44Increased IgM level (HP:0003496)3.35613318
45Myositis (HP:0100614)3.30976966
46Abnormality of eosinophils (HP:0001879)3.28952680
47Congenital stationary night blindness (HP:0007642)3.28556681
48Abnormality of fatty-acid metabolism (HP:0004359)3.24787224
49Conjugated hyperbilirubinemia (HP:0002908)3.20239812
50IgG deficiency (HP:0004315)3.19902791
51Recurrent fungal infections (HP:0002841)3.12560477
52Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.12199830
53Severe combined immunodeficiency (HP:0004430)3.11555377
54Hypercholesterolemia (HP:0003124)3.10168760
55Spontaneous abortion (HP:0005268)3.08283049
56Hyperbilirubinemia (HP:0002904)3.08045031
57Steatorrhea (HP:0002570)3.05505267
58Pancreatic cysts (HP:0001737)3.02611088
59Optic neuritis (HP:0100653)3.00376080
60Retrobulbar optic neuritis (HP:0100654)3.00376080
61Acanthocytosis (HP:0001927)2.99176736
62Granulocytopenia (HP:0001913)2.98693122
63Hypochromic anemia (HP:0001931)2.88159863
64Encephalitis (HP:0002383)2.87887027
65Pustule (HP:0200039)2.83396315
66Abnormality of nucleobase metabolism (HP:0010932)2.81016046
67Dicarboxylic aciduria (HP:0003215)2.80851505
68Abnormality of dicarboxylic acid metabolism (HP:0010995)2.80851505
69Leukocytosis (HP:0001974)2.80571880
70Chronic mucocutaneous candidiasis (HP:0002728)2.78194682
71Recurrent cutaneous fungal infections (HP:0011370)2.78194682
72Attenuation of retinal blood vessels (HP:0007843)2.78183700
73Myocardial infarction (HP:0001658)2.75659335
74Agammaglobulinemia (HP:0004432)2.72167814
75Delayed CNS myelination (HP:0002188)2.70162876
76Absent rod-and cone-mediated responses on ERG (HP:0007688)2.64589750
77Orchitis (HP:0100796)2.61022746
78Gout (HP:0001997)2.59933265
79Abnormality of B cell number (HP:0010975)2.58954107
80Abnormal rod and cone electroretinograms (HP:0008323)2.57359561
81Lethargy (HP:0001254)2.56343247
82Hypochromic microcytic anemia (HP:0004840)2.55053192
83Genetic anticipation (HP:0003743)2.52804161
84Abnormality of midbrain morphology (HP:0002418)2.51638515
85Molar tooth sign on MRI (HP:0002419)2.51638515
86Gingival bleeding (HP:0000225)2.51324178
87Meningitis (HP:0001287)2.49153114
88Thrombophlebitis (HP:0004418)2.46177469
89Renal cortical cysts (HP:0000803)2.44858969
90Eczematoid dermatitis (HP:0000976)2.42973253
91Hepatocellular carcinoma (HP:0001402)2.41334059
92Abnormality of purine metabolism (HP:0004352)2.40061448
93Metabolic acidosis (HP:0001942)2.40052977
94Vasculitis (HP:0002633)2.39206456
95Birth length less than 3rd percentile (HP:0003561)2.36836257
96Decreased central vision (HP:0007663)2.36779602
97Thyroiditis (HP:0100646)2.36412819
98Abnormality of the renal cortex (HP:0011035)2.35346841
99Pancreatic fibrosis (HP:0100732)2.35291744
100Pancreatitis (HP:0001733)2.30183045
101Abolished electroretinogram (ERG) (HP:0000550)2.29094770
102Recurrent gram-negative bacterial infections (HP:0005420)2.27563321
103Spastic diplegia (HP:0001264)2.26229267
104Menorrhagia (HP:0000132)2.23947627
105Progressive inability to walk (HP:0002505)2.23804968
106Gaze-evoked nystagmus (HP:0000640)2.23552580
107Keratoconjunctivitis (HP:0001096)2.23251367
108Combined immunodeficiency (HP:0005387)2.22956988
109Generalized aminoaciduria (HP:0002909)2.22450369
110Brushfield spots (HP:0001088)2.19099042
111Epistaxis (HP:0000421)2.18649529
112Hyperventilation (HP:0002883)2.18083640
113Esophageal varix (HP:0002040)2.17717040
114Poikilocytosis (HP:0004447)2.13353550
115Irritability (HP:0000737)2.12141868
116Abnormality of iron homeostasis (HP:0011031)2.11814075
117Skin nodule (HP:0200036)2.11772159
118Alveolar cell carcinoma (HP:0006519)2.10785441
119True hermaphroditism (HP:0010459)2.10320045
120Clumsiness (HP:0002312)2.09509350
121Recurrent bacterial skin infections (HP:0005406)2.08490383
122Pulmonary infiltrates (HP:0002113)2.08424189
123Abnormality of transition element cation homeostasis (HP:0011030)2.07667484
124Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07249155
125Chronic diarrhea (HP:0002028)2.06409592
126Abnormality of the prostate (HP:0008775)2.05541945
127Systemic lupus erythematosus (HP:0002725)2.04826530
128Hemoptysis (HP:0002105)2.04444854
129Ketoacidosis (HP:0001993)2.04028930
130Reduced antithrombin III activity (HP:0001976)2.03402390
131Hypoproteinemia (HP:0003075)2.02206607
132Type II lissencephaly (HP:0007260)2.01947801
133Keratoconjunctivitis sicca (HP:0001097)2.01937445
134Pulmonary embolism (HP:0002204)2.01739985
135Hypoplasia of the thymus (HP:0000778)2.01711526
136Neoplasm of the tracheobronchial system (HP:0100552)2.01320575
137Malnutrition (HP:0004395)2.00915651
138Neutropenia (HP:0001875)2.00632796
139Progressive cerebellar ataxia (HP:0002073)2.00272237
140Nausea (HP:0002018)1.99886157
141Nephronophthisis (HP:0000090)1.99551647
142Neonatal onset (HP:0003623)1.99183481
143Recurrent skin infections (HP:0001581)1.98592217
144Recurrent abscess formation (HP:0002722)1.98232064
145Constricted visual fields (HP:0001133)1.97399906
146Joint swelling (HP:0001386)1.95763483
147Recurrent viral infections (HP:0004429)1.95429395
148Gastrointestinal infarctions (HP:0005244)1.94973502
149Decreased circulating renin level (HP:0003351)1.94529110
150Inability to walk (HP:0002540)1.94321767
151Mediastinal lymphadenopathy (HP:0100721)1.93901427
152Vascular calcification (HP:0004934)1.92824609
153Glomerulonephritis (HP:0000099)1.92694003
154Fair hair (HP:0002286)1.92442440
155Elevated hepatic transaminases (HP:0002910)1.91029400
156Increased serum ferritin (HP:0003281)1.89848390
157Verrucae (HP:0200043)1.89238118
158Papilloma (HP:0012740)1.89238118
159Cerebral edema (HP:0002181)1.88570075
160Chronic hepatic failure (HP:0100626)1.87871284
161B lymphocytopenia (HP:0010976)1.87853525
162Abnormal cartilage morphology (HP:0002763)1.86837784
163Abnormality of cells of the lymphoid lineage (HP:0012140)1.86826413
164Recurrent bronchitis (HP:0002837)1.86761860
165Neonatal hypoglycemia (HP:0001998)1.86494177
166Prolonged bleeding time (HP:0003010)1.86364614
167Abnormality of the renal medulla (HP:0100957)1.86019824
168Hypertriglyceridemia (HP:0002155)1.85152115
169Tetraplegia (HP:0002445)1.84706805
170Polycythemia (HP:0001901)1.82840525
171Large for gestational age (HP:0001520)1.79551147
172Prostate neoplasm (HP:0100787)1.78563455
173Protruding tongue (HP:0010808)1.78398577
174Increased mean platelet volume (HP:0011877)1.77899892
175Hypoglycemic seizures (HP:0002173)1.75768604
176Amyloidosis (HP:0011034)1.74870880
177Oral leukoplakia (HP:0002745)1.73951594
178Microcytic anemia (HP:0001935)1.71923338
179Abnormal platelet volume (HP:0011876)1.71698622
180Abnormality of the heme biosynthetic pathway (HP:0010472)1.71038584
181Acute lymphatic leukemia (HP:0006721)1.70871577
182Abnormal gallbladder morphology (HP:0012437)1.70864053
183Vomiting (HP:0002013)1.69715322
184Hemorrhage of the eye (HP:0011885)1.69500402
185Anorexia (HP:0002039)1.67942853
186Conjunctival telangiectasia (HP:0000524)1.67601360
187Azoospermia (HP:0000027)1.67529515
188Hyperuricemia (HP:0002149)1.66860370
189Increased purine levels (HP:0004368)1.66860370
190Proximal tubulopathy (HP:0000114)1.66849829
191Chest pain (HP:0100749)1.65750793
192Abnormality of the columella (HP:0009929)1.65652619
193IgM deficiency (HP:0002850)1.65525270
194Hemiplegia (HP:0002301)1.65007149
195Widely spaced teeth (HP:0000687)1.64562391
196Generalized hypopigmentation of hair (HP:0011358)1.63238978
197Abnormality of the renal collecting system (HP:0004742)1.59624333
198Abnormal biliary tract physiology (HP:0012439)1.58518345

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.58401561
2BCKDK4.38528507
3FGFR43.56725272
4TLK13.55934494
5TXK2.83463946
6KDR2.63045500
7MAP4K12.60573283
8TAOK32.54990805
9WEE12.31844017
10BUB12.30655499
11ERN12.27262648
12ADRBK22.16936119
13PIK3CA2.05485190
14FES2.04134172
15TYK22.02418128
16ACVR1B1.96856752
17STK161.88461798
18NME21.87426017
19EIF2AK11.85870212
20CAMKK21.81736417
21MAP4K21.81028086
22SIK11.80002947
23JAK31.73539259
24FLT31.67093874
25ZAK1.63601930
26CDK191.60110128
27TIE11.58013038
28BMPR1B1.54349696
29MAPK111.49650140
30ZAP701.48477342
31TEC1.45607447
32IRAK31.44446833
33TNK21.43648252
34MAP2K31.41125645
35EIF2AK31.40944665
36IKBKE1.38511255
37NEK21.38182215
38NEK91.37287239
39ITK1.35005915
40PINK11.32677711
41OXSR11.31859510
42BRSK21.30901944
43ERBB41.29967390
44TSSK61.27997223
45MARK31.25594757
46PLK41.25211356
47DYRK31.23073665
48TBK11.22628338
49RIPK41.20534600
50MAP3K141.13229288
51STK101.12474134
52SIK21.11752309
53PIK3CG1.09621886
54JAK11.08671665
55CDK41.08565782
56NLK1.08066522
57PKN21.07622901
58TGFBR21.06686982
59RPS6KA41.06060410
60PASK1.05353651
61JAK21.05194382
62PIM11.05185491
63NUAK11.04444868
64GRK61.03991286
65HCK1.02849402
66IRAK11.02462555
67PRKCQ1.01539066
68IRAK40.99066468
69BTK0.98549188
70ABL20.95279308
71MAPK40.92345395
72BLK0.91999609
73IKBKB0.89424695
74MAPK130.88865345
75AKT30.86334590
76ADRBK10.84814271
77TGFBR10.83892206
78TNIK0.83110814
79CAMKK10.81988714
80BMPR20.81917679
81WNK30.81064534
82STK38L0.81063878
83GRK70.80240744
84INSRR0.78865402
85EPHA30.78369967
86EIF2AK20.76392127
87MAP2K60.74059426
88SRPK10.72634846
89CDK60.70551710
90TRPM70.70317533
91SIK30.69714519
92WNK40.68506774
93PDK40.67809735
94PDK30.67809735
95FGFR30.67799207
96CSNK1G10.66428440
97MAP3K40.65959310
98MST40.65881847
99EPHA20.65743532
100STK30.65736299
101STK110.64769571
102RAF10.63828440
103MAP2K40.62745081
104MAP3K30.61743390
105DAPK20.61359313
106KIT0.60894964
107CAMK1D0.58680844
108RPS6KB20.57116849
109PRKAA20.56004754
110PLK10.54684513
111MAP3K70.53829566
112MUSK0.53648551
113CSK0.53571489
114CDK70.52789390
115CSF1R0.52641317
116AURKB0.51004936
117GRK50.50182603
118TESK20.49804623
119MAP3K80.49348222
120LCK0.49300236
121MAP3K130.49281793
122MAP3K110.49023886
123PDK10.48523896
124MST1R0.48284495
125IGF1R0.47403930
126CAMK40.47033886
127HIPK20.46886810
128GRK10.46186937
129CHUK0.44983738
130MAP2K20.44970277
131MAPKAPK30.44425909
132PIM20.44002753
133CSNK1G30.43614708
134MATK0.43120753
135MKNK20.43089045
136PTK2B0.41673928
137BRSK10.40330446
138PDK20.39964048
139SYK0.39731099
140VRK10.37850047
141LATS10.37753961
142TTK0.37607380
143LYN0.37478485
144PRKAA10.36531364
145EPHB10.35996136
146MAPK120.35991113
147MAPK70.35164670
148MAPK150.34199197
149STK390.33297762
150CAMK10.32110501
151SGK20.30251496
152PAK30.28759686
153ABL10.28440336
154FGFR20.26332200
155RPS6KA60.26186519

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.39998182
2Graft-versus-host disease_Homo sapiens_hsa053323.41323822
3Nitrogen metabolism_Homo sapiens_hsa009103.17725711
4Allograft rejection_Homo sapiens_hsa053303.14064802
5Autoimmune thyroid disease_Homo sapiens_hsa053203.02470570
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.01136077
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.69381629
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.67900291
9Arginine biosynthesis_Homo sapiens_hsa002202.67651109
10Complement and coagulation cascades_Homo sapiens_hsa046102.64104263
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62699145
12Type I diabetes mellitus_Homo sapiens_hsa049402.43068679
13Tryptophan metabolism_Homo sapiens_hsa003802.39690745
14Fatty acid degradation_Homo sapiens_hsa000712.34815848
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.26959954
16T cell receptor signaling pathway_Homo sapiens_hsa046602.20612478
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.20183807
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.17722036
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.16057821
20Caffeine metabolism_Homo sapiens_hsa002322.15219901
21Asthma_Homo sapiens_hsa053102.15144557
22Vitamin B6 metabolism_Homo sapiens_hsa007502.11755210
23Drug metabolism - other enzymes_Homo sapiens_hsa009832.10860799
24Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05879447
25Peroxisome_Homo sapiens_hsa041462.01214567
26Phototransduction_Homo sapiens_hsa047441.88567498
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.78871549
28Staphylococcus aureus infection_Homo sapiens_hsa051501.78250624
29Folate biosynthesis_Homo sapiens_hsa007901.77869902
30Propanoate metabolism_Homo sapiens_hsa006401.76030066
31Histidine metabolism_Homo sapiens_hsa003401.75033970
32Selenocompound metabolism_Homo sapiens_hsa004501.73844547
33Butanoate metabolism_Homo sapiens_hsa006501.73655376
34Chemical carcinogenesis_Homo sapiens_hsa052041.73229947
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.70820845
36PPAR signaling pathway_Homo sapiens_hsa033201.69139113
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66516068
38beta-Alanine metabolism_Homo sapiens_hsa004101.65787299
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.62483952
40Retinol metabolism_Homo sapiens_hsa008301.62021089
41Fatty acid metabolism_Homo sapiens_hsa012121.59649894
42Hematopoietic cell lineage_Homo sapiens_hsa046401.58799058
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.55363459
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50786912
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49924649
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42248661
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41171883
48Ether lipid metabolism_Homo sapiens_hsa005651.38376730
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.32361362
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29261214
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28855333
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28812905
53B cell receptor signaling pathway_Homo sapiens_hsa046621.27564045
54Biosynthesis of amino acids_Homo sapiens_hsa012301.26733615
55Leishmaniasis_Homo sapiens_hsa051401.25090988
56Osteoclast differentiation_Homo sapiens_hsa043801.23282249
57Fatty acid elongation_Homo sapiens_hsa000621.22612367
58ABC transporters_Homo sapiens_hsa020101.18499397
59Pyruvate metabolism_Homo sapiens_hsa006201.18100472
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17998414
61Phenylalanine metabolism_Homo sapiens_hsa003601.17476952
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17281782
63Vitamin digestion and absorption_Homo sapiens_hsa049771.17101640
64Tyrosine metabolism_Homo sapiens_hsa003501.15370407
65Carbon metabolism_Homo sapiens_hsa012001.14408488
66Fat digestion and absorption_Homo sapiens_hsa049751.13571520
67Pentose phosphate pathway_Homo sapiens_hsa000301.12845338
68Bile secretion_Homo sapiens_hsa049761.12485576
69African trypanosomiasis_Homo sapiens_hsa051431.10978340
70Starch and sucrose metabolism_Homo sapiens_hsa005001.10194605
71Sulfur relay system_Homo sapiens_hsa041221.09176791
72One carbon pool by folate_Homo sapiens_hsa006701.08985975
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03048420
74Dorso-ventral axis formation_Homo sapiens_hsa043201.01542274
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00291912
76Cyanoamino acid metabolism_Homo sapiens_hsa004601.00182357
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97221942
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97039388
79Platelet activation_Homo sapiens_hsa046110.89606275
80Arachidonic acid metabolism_Homo sapiens_hsa005900.89292157
81Steroid biosynthesis_Homo sapiens_hsa001000.88203588
82RNA degradation_Homo sapiens_hsa030180.88168556
83Sulfur metabolism_Homo sapiens_hsa009200.87200487
84Olfactory transduction_Homo sapiens_hsa047400.85786297
85Arginine and proline metabolism_Homo sapiens_hsa003300.83943361
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83122369
87Chemokine signaling pathway_Homo sapiens_hsa040620.81711847
88TNF signaling pathway_Homo sapiens_hsa046680.80276039
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79786456
90Rheumatoid arthritis_Homo sapiens_hsa053230.78829589
91Glutathione metabolism_Homo sapiens_hsa004800.76308453
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.75643524
93Tuberculosis_Homo sapiens_hsa051520.74590565
94Acute myeloid leukemia_Homo sapiens_hsa052210.73040094
95Glycerolipid metabolism_Homo sapiens_hsa005610.72667393
96Influenza A_Homo sapiens_hsa051640.72117352
97Viral myocarditis_Homo sapiens_hsa054160.71622687
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70454947
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67736003
100Morphine addiction_Homo sapiens_hsa050320.66729169
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65676635
102Toxoplasmosis_Homo sapiens_hsa051450.63375305
103Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62783937
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61929447
105FoxO signaling pathway_Homo sapiens_hsa040680.61323772
106Pyrimidine metabolism_Homo sapiens_hsa002400.61265518
107Lysine degradation_Homo sapiens_hsa003100.58139711
108Fanconi anemia pathway_Homo sapiens_hsa034600.57619623
109Taste transduction_Homo sapiens_hsa047420.55950396
110Metabolic pathways_Homo sapiens_hsa011000.53680309
111Circadian rhythm_Homo sapiens_hsa047100.53081303
112Malaria_Homo sapiens_hsa051440.51551335
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50757672
114Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49344537
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46902922
116RNA polymerase_Homo sapiens_hsa030200.45704955
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45530238
118Hepatitis B_Homo sapiens_hsa051610.45220380
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43886686
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43831293
121Calcium signaling pathway_Homo sapiens_hsa040200.43278368
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42973404
123Legionellosis_Homo sapiens_hsa051340.42734725
124Fatty acid biosynthesis_Homo sapiens_hsa000610.41704796
125MAPK signaling pathway_Homo sapiens_hsa040100.41670833
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.40014382
127Epstein-Barr virus infection_Homo sapiens_hsa051690.39556285
128Galactose metabolism_Homo sapiens_hsa000520.38765924
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38422019
130Proteasome_Homo sapiens_hsa030500.37855570
131Type II diabetes mellitus_Homo sapiens_hsa049300.37693978
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37624563
133Ovarian steroidogenesis_Homo sapiens_hsa049130.36790990
134Serotonergic synapse_Homo sapiens_hsa047260.36146391
135Prolactin signaling pathway_Homo sapiens_hsa049170.35854446
136Regulation of autophagy_Homo sapiens_hsa041400.35672742
137Primary immunodeficiency_Homo sapiens_hsa053400.34062722
138Intestinal immune network for IgA production_Homo sapiens_hsa046720.33813678
139DNA replication_Homo sapiens_hsa030300.33550069
140Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33419188
141Apoptosis_Homo sapiens_hsa042100.31854490
142Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28991285
143Renin secretion_Homo sapiens_hsa049240.28854566
144Fructose and mannose metabolism_Homo sapiens_hsa000510.28568946
145Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.26047351
146Ribosome_Homo sapiens_hsa030100.24870538
147alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24479669
148Adipocytokine signaling pathway_Homo sapiens_hsa049200.23818350
149Linoleic acid metabolism_Homo sapiens_hsa005910.19630688
150Antigen processing and presentation_Homo sapiens_hsa046120.19205391
151Insulin resistance_Homo sapiens_hsa049310.18395923
152Prion diseases_Homo sapiens_hsa050200.16391882
153Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.13409885
154Purine metabolism_Homo sapiens_hsa002300.12797241
155NF-kappa B signaling pathway_Homo sapiens_hsa040640.10668439
156Measles_Homo sapiens_hsa051620.10548643
157Mismatch repair_Homo sapiens_hsa034300.07002967
158p53 signaling pathway_Homo sapiens_hsa041150.06381492
159Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.06077923
160RNA transport_Homo sapiens_hsa030130.05030289
161Homologous recombination_Homo sapiens_hsa034400.04993818
162Herpes simplex infection_Homo sapiens_hsa051680.03371733
163* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.03152049
164Basal transcription factors_Homo sapiens_hsa030220.01244114

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