RNF126

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heterochromatin organization (GO:0070828)4.89742202
2fusion of sperm to egg plasma membrane (GO:0007342)4.61737998
3sperm motility (GO:0030317)4.61645030
4sperm-egg recognition (GO:0035036)4.58776177
5binding of sperm to zona pellucida (GO:0007339)4.53489890
6DNA deamination (GO:0045006)4.45749686
7negative regulation of erythrocyte differentiation (GO:0045647)4.43798706
8modulation by virus of host process (GO:0019054)4.23771283
9protein localization to chromosome, centromeric region (GO:0071459)4.17773640
10synaptonemal complex assembly (GO:0007130)4.17113349
11cell-cell recognition (GO:0009988)4.08827705
12cell wall macromolecule catabolic process (GO:0016998)4.07253456
13cell wall macromolecule metabolic process (GO:0044036)4.07253456
14chromosome condensation (GO:0030261)3.98364488
15synaptonemal complex organization (GO:0070193)3.97655391
16deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.92932643
17viral transcription (GO:0019083)3.91401095
18modulation by symbiont of host cellular process (GO:0044068)3.82051908
19NIK/NF-kappaB signaling (GO:0038061)3.78374988
20spermatid development (GO:0007286)3.77904634
21regulation of translational fidelity (GO:0006450)3.75216768
22translational termination (GO:0006415)3.75048148
23acrosome reaction (GO:0007340)3.72190417
24motile cilium assembly (GO:0044458)3.69018535
25DNA unwinding involved in DNA replication (GO:0006268)3.67190664
26mitotic nuclear envelope disassembly (GO:0007077)3.64865297
27mitotic sister chromatid segregation (GO:0000070)3.64409202
28protein localization to kinetochore (GO:0034501)3.64152832
29piRNA metabolic process (GO:0034587)3.63363419
30intracellular estrogen receptor signaling pathway (GO:0030520)3.62833089
31positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.61438390
32acrosome assembly (GO:0001675)3.60937064
33translational elongation (GO:0006414)3.60809205
34negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.58723181
35DNA packaging (GO:0006323)3.56086133
36folic acid-containing compound biosynthetic process (GO:0009396)3.53506068
37DNA replication-dependent nucleosome assembly (GO:0006335)3.52340924
38DNA replication-dependent nucleosome organization (GO:0034723)3.52340924
39microtubule depolymerization (GO:0007019)3.50661880
40regulation of mammary gland epithelial cell proliferation (GO:0033599)3.50450081
41formation of translation preinitiation complex (GO:0001731)3.47717260
42thymic T cell selection (GO:0045061)3.47238809
43peptidyl-arginine omega-N-methylation (GO:0035247)3.46561841
44nuclear envelope disassembly (GO:0051081)3.45178398
45membrane disassembly (GO:0030397)3.45178398
46protein-DNA complex disassembly (GO:0032986)3.42879208
47nucleosome disassembly (GO:0006337)3.42879208
48nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.41496406
49translational initiation (GO:0006413)3.37885869
50negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.37363371
51regulation of cilium movement (GO:0003352)3.36376207
52plasma membrane fusion (GO:0045026)3.34313835
53RNA stabilization (GO:0043489)3.32958870
54mRNA stabilization (GO:0048255)3.32958870
55positive thymic T cell selection (GO:0045059)3.30043674
56chaperone-mediated protein complex assembly (GO:0051131)3.29145419
57male meiosis (GO:0007140)3.27387119
58ribosomal small subunit biogenesis (GO:0042274)3.27010852
59maternal placenta development (GO:0001893)3.26715030
60nuclear pore complex assembly (GO:0051292)3.26376080
61gene silencing by RNA (GO:0031047)3.25022697
62sister chromatid segregation (GO:0000819)3.20929580
63DNA strand elongation involved in DNA replication (GO:0006271)3.19696015
64chromatin silencing (GO:0006342)3.18851020
65regulation of translational termination (GO:0006449)3.18801601
66mitotic G1 DNA damage checkpoint (GO:0031571)3.18448393
67protein complex disassembly (GO:0043241)3.18296504
68gene silencing (GO:0016458)3.17291057
69chromatin assembly (GO:0031497)3.17195283
70negative regulation of RNA splicing (GO:0033119)3.16702191
71negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.14958041
72multicellular organism reproduction (GO:0032504)3.14714521
73pre-miRNA processing (GO:0031054)3.13347237
74protein complex localization (GO:0031503)3.12571536
75maturation of SSU-rRNA (GO:0030490)3.11284477
76cellular protein complex disassembly (GO:0043624)3.11103378
77dosage compensation (GO:0007549)3.10773086
78DNA replication initiation (GO:0006270)3.10106906
79ribosomal small subunit assembly (GO:0000028)3.10068317
80nuclear pore organization (GO:0006999)3.09874696
81negative regulation of mRNA metabolic process (GO:1903312)3.08124847
82regulation of histone H3-K9 methylation (GO:0051570)3.07818057
83negative regulation of necroptotic process (GO:0060546)3.07816205
84histone arginine methylation (GO:0034969)3.07018649
853-UTR-mediated mRNA stabilization (GO:0070935)3.06791809
86regulation of posttranscriptional gene silencing (GO:0060147)3.06767644
87regulation of gene silencing by miRNA (GO:0060964)3.06767644
88regulation of gene silencing by RNA (GO:0060966)3.06767644
89axonemal dynein complex assembly (GO:0070286)3.06111964
90activation of MAPKKK activity (GO:0000185)3.05787869
91negative regulation of mRNA processing (GO:0050686)3.02359773
92negative regulation of gene expression, epigenetic (GO:0045814)3.01229209
93peptidyl-lysine dimethylation (GO:0018027)2.99342661
94regulation of chromatin binding (GO:0035561)2.99031287
95DNA strand elongation (GO:0022616)2.98899692
96ncRNA 3-end processing (GO:0043628)2.98720200
97spliceosomal tri-snRNP complex assembly (GO:0000244)2.95505116
98reproduction (GO:0000003)2.94663965
99pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.93788865
100viral life cycle (GO:0019058)2.92742218
101apoptotic process involved in morphogenesis (GO:0060561)2.92083230
102positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.92000573
103macromolecular complex disassembly (GO:0032984)2.91049294
104regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.90587818
105establishment of apical/basal cell polarity (GO:0035089)2.89943460
106interferon-gamma secretion (GO:0072643)2.88851469
107regulation of monocyte differentiation (GO:0045655)2.88101126
108RNA localization (GO:0006403)2.86546503
109positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.85906229
110proline biosynthetic process (GO:0006561)2.85062776
111telomere maintenance via semi-conservative replication (GO:0032201)2.84288874
112DNA conformation change (GO:0071103)2.83907270
113spermatogenesis (GO:0007283)2.83567164
114GDP-mannose metabolic process (GO:0019673)2.83396574
115nuclear envelope organization (GO:0006998)2.83346385
116peptidyl-arginine methylation (GO:0018216)2.83016633
117peptidyl-arginine N-methylation (GO:0035246)2.83016633
118male gamete generation (GO:0048232)2.82993550
119T cell selection (GO:0045058)2.81321604
120antigen processing and presentation of endogenous antigen (GO:0019883)2.81249534
121antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.78403973
122poly(A)+ mRNA export from nucleus (GO:0016973)2.75698175
123pyrimidine nucleoside salvage (GO:0043097)2.73296617
124pyrimidine-containing compound salvage (GO:0008655)2.73296617
125negative regulation of cell killing (GO:0031342)2.73001216
126negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.73001216
127positive regulation of gamma-delta T cell activation (GO:0046645)2.71788001
128modulation by symbiont of host immune response (GO:0052553)2.69391451
129positive regulation by symbiont of host defense response (GO:0052509)2.69391451
130modulation by symbiont of host defense response (GO:0052031)2.69391451
131modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.69391451
132modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.69391451
133positive regulation by organism of defense response of other organism involved in symbiotic interact2.69391451
134ribonucleoprotein complex biogenesis (GO:0022613)2.69337015
135negative regulation of viral release from host cell (GO:1902187)2.67731537
136regulation of type I interferon-mediated signaling pathway (GO:0060338)2.67589748
137regulation of necrotic cell death (GO:0010939)2.66302968
138nucleotide salvage (GO:0043173)2.66087434
139negative regulation of B cell apoptotic process (GO:0002903)2.66055426
140tolerance induction (GO:0002507)2.65578697
141leukocyte aggregation (GO:0070486)2.65223146
142antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.63948927
143negative regulation of cell size (GO:0045792)2.62820093
144pyrimidine nucleotide catabolic process (GO:0006244)2.62346552
145mucosal-associated lymphoid tissue development (GO:0048537)2.62078058
146Peyers patch development (GO:0048541)2.62078058
147mannose metabolic process (GO:0006013)2.60776214
148modulation by virus of host morphology or physiology (GO:0019048)2.60223517
149SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.60120914
150cellular response to interleukin-4 (GO:0071353)2.59186332
151CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.58526739
152pattern specification involved in kidney development (GO:0061004)2.57433876
153negative regulation of DNA-templated transcription, elongation (GO:0032785)2.57224336
154response to muramyl dipeptide (GO:0032495)2.57085802
155protein targeting to ER (GO:0045047)2.56918805
156regulation of superoxide anion generation (GO:0032928)2.56782192
157pentose-phosphate shunt (GO:0006098)2.55650382
158pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.55615620
159protein maturation by protein folding (GO:0022417)2.55126785
160pinocytosis (GO:0006907)2.50630150
161regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.50002860
162negative regulation of myeloid cell apoptotic process (GO:0033033)2.49644851
163cotranslational protein targeting to membrane (GO:0006613)2.46649415
164UV protection (GO:0009650)2.45818015
165positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.45606050
166pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.43574395
167negative regulation of phagocytosis (GO:0050765)2.42142959
168deoxyribose phosphate biosynthetic process (GO:0046385)2.41249412
1692-deoxyribonucleotide biosynthetic process (GO:0009265)2.41249412
170positive T cell selection (GO:0043368)2.40416945
171protein localization to endoplasmic reticulum (GO:0070972)2.40005109
172regulation of defense response to virus by virus (GO:0050690)2.39855797
173establishment of protein localization to endoplasmic reticulum (GO:0072599)2.39320624
174negative thymic T cell selection (GO:0045060)2.38877582
175proline metabolic process (GO:0006560)2.38653769

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.08798828
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.21202656
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.74123102
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.35810378
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.94043535
6MYC_22102868_ChIP-Seq_BL_Human2.93418599
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45240958
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.41381563
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28953702
10* VDR_21846776_ChIP-Seq_THP-1_Human2.23439982
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.07180963
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05892981
13E2F4_17652178_ChIP-ChIP_JURKAT_Human1.98731502
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97408435
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89876730
16XRN2_22483619_ChIP-Seq_HELA_Human1.88712525
17MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85276596
18TCF7_22412390_ChIP-Seq_EML_Mouse1.85054213
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.83617772
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.83146905
21ZNF263_19887448_ChIP-Seq_K562_Human1.76877782
22LXR_22292898_ChIP-Seq_THP-1_Human1.71732813
23* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.69598183
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.65180417
25KDM2B_26808549_Chip-Seq_DND41_Human1.63662655
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61257941
27KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.60949933
28SRY_22984422_ChIP-ChIP_TESTIS_Rat1.60903762
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.60347509
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57905676
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55346367
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.54490699
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.53361325
34* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.51464918
35KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50467408
36* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46850636
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46121850
38ELF1_20517297_ChIP-Seq_JURKAT_Human1.44067324
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43435070
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43093068
41* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40470482
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37436882
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37170427
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.36557603
45* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36555239
46TET1_21451524_ChIP-Seq_MESCs_Mouse1.36499863
47P68_20966046_ChIP-Seq_HELA_Human1.35900613
48UTX_26944678_Chip-Seq_JUKART_Human1.32790091
49* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32687701
50YY1_22570637_ChIP-Seq_MALME-3M_Human1.30837248
51KDM5A_27292631_Chip-Seq_BREAST_Human1.29573347
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28308052
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.28127624
54* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27867657
55* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25227189
56MAF_26560356_Chip-Seq_TH1_Human1.25205912
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25198891
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25165066
59RACK7_27058665_Chip-Seq_MCF-7_Human1.25125182
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24545827
61SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.24487646
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23969295
63PHF8_20622854_ChIP-Seq_HELA_Human1.23522780
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.23008971
65CIITA_25753668_ChIP-Seq_RAJI_Human1.21664273
66KDM2B_26808549_Chip-Seq_K562_Human1.21472411
67PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21094138
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.20987682
69BCOR_27268052_Chip-Seq_Bcells_Human1.20751708
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19962144
71ATF3_27146783_Chip-Seq_COLON_Human1.19902059
72GABP_19822575_ChIP-Seq_HepG2_Human1.19369470
73* MAF_26560356_Chip-Seq_TH2_Human1.18606946
74ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18298351
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17320628
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17216927
77BCL6_27268052_Chip-Seq_Bcells_Human1.16761176
78NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16149276
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16132992
80TTF2_22483619_ChIP-Seq_HELA_Human1.14960545
81* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14671417
82TP63_17297297_ChIP-ChIP_HaCaT_Human1.13997038
83* FOXP1_21924763_ChIP-Seq_HESCs_Human1.13759151
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13420553
85* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12398250
86CREB1_26743006_Chip-Seq_LNCaP_Human1.12224239
87TP53_22127205_ChIP-Seq_IMR90_Human1.11889389
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11569045
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10797654
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10370977
91NCOR1_26117541_ChIP-Seq_K562_Human1.09175496
92STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08876755
93* SA1_27219007_Chip-Seq_ERYTHROID_Human1.08612639
94JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.07181629
95YY1_21170310_ChIP-Seq_MESCs_Mouse1.07154903
96DCP1A_22483619_ChIP-Seq_HELA_Human1.06429418
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06397990
98VDR_24763502_ChIP-Seq_THP-1_Human1.06237265
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05383136
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05326961
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04560622
102ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03649866
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03596183
104HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.03501298
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02569946
106KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02277135
107AR_21909140_ChIP-Seq_LNCAP_Human1.02263238
108* ETS1_21867929_ChIP-Seq_TH2_Mouse1.01904775
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01377123
110NANOG_21062744_ChIP-ChIP_HESCs_Human1.01313537
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00822958
112RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00720501
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00610017
114ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00357150
115CTCF_21964334_Chip-Seq_Bcells_Human0.99823698
116E2F1_20622854_ChIP-Seq_HELA_Human0.99648171
117SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99421335
118NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99340780
119CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98876581
120CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98266426
121CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97357414
122RUNX1_22412390_ChIP-Seq_EML_Mouse0.97128392
123* CTCF_26484167_Chip-Seq_Bcells_Mouse0.96263006
124* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95472422
125THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94519588
126* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94117698
127* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93783810
128SMC4_20622854_ChIP-Seq_HELA_Human0.93122540
129* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92079149

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.30186687
2MP0005451_abnormal_body_composition3.55676331
3MP0003111_abnormal_nucleus_morphology3.20364059
4MP0003436_decreased_susceptibility_to3.09531944
5MP0003705_abnormal_hypodermis_morpholog3.07623474
6MP0002653_abnormal_ependyma_morphology3.07384085
7MP0003693_abnormal_embryo_hatching3.04877243
8MP0004957_abnormal_blastocyst_morpholog2.94617720
9MP0010352_gastrointestinal_tract_polyps2.88371919
10MP0005076_abnormal_cell_differentiation2.66495363
11MP0010094_abnormal_chromosome_stability2.63290144
12MP0003077_abnormal_cell_cycle2.48429775
13MP0008260_abnormal_autophagy2.43445058
14MP0001929_abnormal_gametogenesis2.36949250
15MP0005058_abnormal_lysosome_morphology2.32862397
16MP0003698_abnormal_male_reproductive2.23396110
17MP0008877_abnormal_DNA_methylation2.21941675
18MP0001730_embryonic_growth_arrest2.19532269
19MP0009278_abnormal_bone_marrow2.19018679
20MP0004858_abnormal_nervous_system2.16761920
21MP0008057_abnormal_DNA_replication1.97882182
22MP0004233_abnormal_muscle_weight1.96211418
23MP0010030_abnormal_orbit_morphology1.94710428
24MP0000350_abnormal_cell_proliferation1.86736642
25MP0001873_stomach_inflammation1.86458772
26MP0002210_abnormal_sex_determination1.84484495
27MP0005397_hematopoietic_system_phenotyp1.83231485
28MP0001545_abnormal_hematopoietic_system1.83231485
29MP0004947_skin_inflammation1.82852852
30MP0005000_abnormal_immune_tolerance1.73527265
31MP0004197_abnormal_fetal_growth/weight/1.69516712
32MP0001697_abnormal_embryo_size1.69419893
33MP0008007_abnormal_cellular_replicative1.66556063
34MP0005387_immune_system_phenotype1.66214496
35MP0001790_abnormal_immune_system1.66214496
36MP0001145_abnormal_male_reproductive1.66195274
37MP0001800_abnormal_humoral_immune1.65731240
38MP0001849_ear_inflammation1.62951716
39MP0005380_embryogenesis_phenotype1.61682215
40MP0001672_abnormal_embryogenesis/_devel1.61682215
41MP0002084_abnormal_developmental_patter1.61660368
42MP0002420_abnormal_adaptive_immunity1.60538188
43MP0005025_abnormal_response_to1.60346256
44MP0001819_abnormal_immune_cell1.58166829
45MP0005623_abnormal_meninges_morphology1.57737428
46MP0010307_abnormal_tumor_latency1.57394576
47MP0008932_abnormal_embryonic_tissue1.57250558
48MP0002085_abnormal_embryonic_tissue1.56950569
49MP0002080_prenatal_lethality1.54047814
50MP0003123_paternal_imprinting1.52196618
51MP0002723_abnormal_immune_serum1.52060993
52MP0005671_abnormal_response_to1.49198940
53MP0001835_abnormal_antigen_presentation1.47295753
54MP0002086_abnormal_extraembryonic_tissu1.47207399
55MP0003984_embryonic_growth_retardation1.46522841
56MP0000490_abnormal_crypts_of1.46050670
57MP0000716_abnormal_immune_system1.45164596
58MP0002088_abnormal_embryonic_growth/wei1.42941180
59MP0002452_abnormal_antigen_presenting1.42857964
60MP0002161_abnormal_fertility/fecundity1.41519447
61MP0002396_abnormal_hematopoietic_system1.41344201
62MP0004510_myositis1.38139767
63MP0002429_abnormal_blood_cell1.38066895
64MP0008058_abnormal_DNA_repair1.37878893
65MP0003806_abnormal_nucleotide_metabolis1.37796155
66MP0004808_abnormal_hematopoietic_stem1.37167388
67MP0003172_abnormal_lysosome_physiology1.34898369
68MP0000653_abnormal_sex_gland1.32227331
69MP0002419_abnormal_innate_immunity1.31149619
70MP0003119_abnormal_digestive_system1.31005390
71MP0002132_abnormal_respiratory_system1.30679878
72MP0005464_abnormal_platelet_physiology1.28195458
73MP0001853_heart_inflammation1.27748056
74MP0000313_abnormal_cell_death1.27328226
75MP0009379_abnormal_foot_pigmentation1.25935249
76MP0002019_abnormal_tumor_incidence1.23820647
77MP0005023_abnormal_wound_healing1.23077530
78MP0009333_abnormal_splenocyte_physiolog1.21450286
79MP0002089_abnormal_postnatal_growth/wei1.21265865
80MP0005666_abnormal_adipose_tissue1.20936897
81MP0003283_abnormal_digestive_organ1.18814086
82MP0000733_abnormal_muscle_development1.17300398
83MP0008961_abnormal_basal_metabolism1.16783143
84MP0003303_peritoneal_inflammation1.16760216
85MP0003566_abnormal_cell_adhesion1.16704923
86MP0000681_abnormal_thyroid_gland1.14061826
87MP0003191_abnormal_cellular_cholesterol1.13143728
88MP0000703_abnormal_thymus_morphology1.12791804
89MP0008770_decreased_survivor_rate1.12222693
90MP0010155_abnormal_intestine_physiology1.11386524
91MP0005501_abnormal_skin_physiology1.11264689
92MP0002148_abnormal_hypersensitivity_rea1.11243639
93MP0003115_abnormal_respiratory_system1.09679140
94MP0002234_abnormal_pharynx_morphology1.09647396
95MP0009672_abnormal_birth_weight1.09535922
96MP0009053_abnormal_anal_canal1.07086068
97MP0005375_adipose_tissue_phenotype1.05247860
98MP0009785_altered_susceptibility_to1.05118099
99MP0000750_abnormal_muscle_regeneration1.04424090
100MP0003567_abnormal_fetal_cardiomyocyte1.04413164
101MP0003786_premature_aging1.02786761
102MP0001293_anophthalmia1.02254261
103MP0002269_muscular_atrophy1.02234903
104MP0000678_abnormal_parathyroid_gland1.01167255
105MP0001348_abnormal_lacrimal_gland1.00710444
106MP0002796_impaired_skin_barrier0.98730046
107MP0000858_altered_metastatic_potential0.98217408
108MP0000465_gastrointestinal_hemorrhage0.97561029
109MP0004381_abnormal_hair_follicle0.97096958
110MP0000358_abnormal_cell_content/0.96992800
111MP0009840_abnormal_foam_cell0.96207634
112MP0000003_abnormal_adipose_tissue0.92655826
113MP0005670_abnormal_white_adipose0.92386391
114MP0006036_abnormal_mitochondrial_physio0.88803653
115MP0001533_abnormal_skeleton_physiology0.88502280
116MP0000759_abnormal_skeletal_muscle0.88489819
117MP0003329_amyloid_beta_deposits0.87180238
118MP0002398_abnormal_bone_marrow0.87021515
119MP0005360_urolithiasis0.86599557
120MP0003942_abnormal_urinary_system0.85866517
121MP0001845_abnormal_inflammatory_respons0.85588550
122MP0003646_muscle_fatigue0.84432789
123MP0005330_cardiomyopathy0.83802001
124MP0001915_intracranial_hemorrhage0.83499301
125MP0003763_abnormal_thymus_physiology0.82870298
126MP0002722_abnormal_immune_system0.82750783
127MP0005621_abnormal_cell_physiology0.82433555
128MP0004133_heterotaxia0.80614476
129MP0002163_abnormal_gland_morphology0.80552194
130MP0002160_abnormal_reproductive_system0.80414422
131MP0001727_abnormal_embryo_implantation0.78385572
132MP0002092_abnormal_eye_morphology0.77610018
133MP0009703_decreased_birth_body0.77204740
134MP0008469_abnormal_protein_level0.76836707
135MP0002925_abnormal_cardiovascular_devel0.76607193
136MP0002877_abnormal_melanocyte_morpholog0.75741813
137MP0002282_abnormal_trachea_morphology0.74780345
138MP0003453_abnormal_keratinocyte_physiol0.74659843
139MP0000689_abnormal_spleen_morphology0.74299261
140MP0002111_abnormal_tail_morphology0.73563427
141MP0004185_abnormal_adipocyte_glucose0.73218797
142MP0002970_abnormal_white_adipose0.72374616
143MP0002249_abnormal_larynx_morphology0.71889076
144MP0002138_abnormal_hepatobiliary_system0.71310573
145MP0002998_abnormal_bone_remodeling0.71193816
146MP0002932_abnormal_joint_morphology0.70910376
147MP0002405_respiratory_system_inflammati0.69508063
148MP0000685_abnormal_immune_system0.68964746
149MP0003300_gastrointestinal_ulcer0.68280633
150MP0009931_abnormal_skin_appearance0.68003811
151MP0000477_abnormal_intestine_morphology0.67321182
152MP0010630_abnormal_cardiac_muscle0.66088727

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)4.71594100
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.14518837
3Absent/shortened dynein arms (HP:0200106)4.14518837
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.13040879
5Abnormality of the nasal mucosa (HP:0000433)3.81163825
6Abnormality of the lower motor neuron (HP:0002366)3.54467953
7Selective tooth agenesis (HP:0001592)3.53183584
8Abnormality of cells of the erythroid lineage (HP:0012130)3.44078611
9Abnormal number of erythroid precursors (HP:0012131)3.33433256
10Hyperacusis (HP:0010780)3.16063232
11Ragged-red muscle fibers (HP:0003200)3.11384522
12Hypertensive crisis (HP:0100735)3.03863914
13Male infertility (HP:0003251)3.00164274
14Abnormal respiratory epithelium morphology (HP:0012253)2.99022238
15Abnormal respiratory motile cilium morphology (HP:0005938)2.99022238
16Infertility (HP:0000789)2.97103811
17Ependymoma (HP:0002888)2.91344783
18Centrally nucleated skeletal muscle fibers (HP:0003687)2.90614901
19Eczematoid dermatitis (HP:0000976)2.90076767
20Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.82672590
21Myopathic facies (HP:0002058)2.81742723
22Difficulty climbing stairs (HP:0003551)2.78490493
23Chronic obstructive pulmonary disease (HP:0006510)2.77309598
24Obstructive lung disease (HP:0006536)2.77309598
25Seborrheic dermatitis (HP:0001051)2.77116435
26Chronic bronchitis (HP:0004469)2.76648052
27Cellulitis (HP:0100658)2.74634767
28Basal cell carcinoma (HP:0002671)2.73718037
29Abnormality of the anterior horn cell (HP:0006802)2.71106427
30Degeneration of anterior horn cells (HP:0002398)2.71106427
31Impulsivity (HP:0100710)2.68819691
32Renal duplication (HP:0000075)2.66628751
33Achilles tendon contracture (HP:0001771)2.60245241
34Broad distal phalanx of finger (HP:0009836)2.59495590
35Truncus arteriosus (HP:0001660)2.59066979
36Reticulocytopenia (HP:0001896)2.53434395
37Trismus (HP:0000211)2.52344316
38Gastrointestinal inflammation (HP:0004386)2.49646467
39Deep palmar crease (HP:0006191)2.48338542
40Colitis (HP:0002583)2.47455480
41Upper limb amyotrophy (HP:0009129)2.47235345
42Distal upper limb amyotrophy (HP:0007149)2.47235345
43Gastrointestinal stroma tumor (HP:0100723)2.46218340
44Protrusio acetabuli (HP:0003179)2.43261265
45Mediastinal lymphadenopathy (HP:0100721)2.41620589
46Genu recurvatum (HP:0002816)2.40098109
47Increased IgE level (HP:0003212)2.39294827
48Rhinitis (HP:0012384)2.39082029
49Long palpebral fissure (HP:0000637)2.38279252
50Hyperthyroidism (HP:0000836)2.36060094
51Abnormal respiratory motile cilium physiology (HP:0012261)2.34255920
52Distal lower limb amyotrophy (HP:0008944)2.32664127
53Hand muscle atrophy (HP:0009130)2.32552769
54Increased serum ferritin (HP:0003281)2.30915256
55Abnormality of the Achilles tendon (HP:0005109)2.30895187
56Stridor (HP:0010307)2.29831647
57Agammaglobulinemia (HP:0004432)2.27381070
58Upper motor neuron abnormality (HP:0002127)2.25674542
59Aplasia/Hypoplasia of the thymus (HP:0010515)2.21943416
60Insomnia (HP:0100785)2.21328752
61Recurrent bacterial skin infections (HP:0005406)2.20784617
62Aplasia/hypoplasia of the humerus (HP:0006507)2.20071685
63Microvesicular hepatic steatosis (HP:0001414)2.19788838
64Increased nuchal translucency (HP:0010880)2.18728548
65Bronchitis (HP:0012387)2.16740857
66Short humerus (HP:0005792)2.15711879
67Abnormality of reticulocytes (HP:0004312)2.15403835
68Elevated erythrocyte sedimentation rate (HP:0003565)2.15356028
69Exercise-induced myalgia (HP:0003738)2.15307991
70Rib fusion (HP:0000902)2.14997315
71Heterotopia (HP:0002282)2.14992047
72Squamous cell carcinoma (HP:0002860)2.14857106
73Abnormality of the columella (HP:0009929)2.13847974
74Abnormality of the thoracic spine (HP:0100711)2.13400099
75Astrocytoma (HP:0009592)2.12263242
76Abnormality of the astrocytes (HP:0100707)2.12263242
77Meningitis (HP:0001287)2.12188897
78Recurrent abscess formation (HP:0002722)2.12157354
79Axonal loss (HP:0003447)2.11785141
80Cerebral aneurysm (HP:0004944)2.11245478
81Ulnar bowing (HP:0003031)2.11122302
82Renovascular hypertension (HP:0100817)2.11027344
83Vertebral compression fractures (HP:0002953)2.10133548
84Pustule (HP:0200039)2.09927342
85Angiofibromas (HP:0010615)2.08858144
86Adenoma sebaceum (HP:0009720)2.08858144
87Petechiae (HP:0000967)2.08826790
88High pitched voice (HP:0001620)2.08743322
89Recurrent viral infections (HP:0004429)2.08485539
90Verrucae (HP:0200043)2.06955198
91Papilloma (HP:0012740)2.06955198
92Multiple enchondromatosis (HP:0005701)2.06796060
93Increased density of long bones (HP:0006392)2.05946558
94Absent thumb (HP:0009777)2.04734779
95Distal lower limb muscle weakness (HP:0009053)2.03775382
96Inflammation of the large intestine (HP:0002037)2.02736624
97Thoracic kyphosis (HP:0002942)2.02688452
98Increased connective tissue (HP:0009025)2.02627501
99Hemorrhage of the eye (HP:0011885)2.01984466
100Atrophy/Degeneration involving motor neurons (HP:0007373)2.01045825
101Broad palm (HP:0001169)1.98944080
102Abnormality of the tricuspid valve (HP:0001702)1.98088456
103Polygenic inheritance (HP:0010982)1.97894877
104Annular pancreas (HP:0001734)1.96825232
105Easy fatigability (HP:0003388)1.96739139
106Amyotrophic lateral sclerosis (HP:0007354)1.96433359
107Pallor (HP:0000980)1.96008545
108Missing ribs (HP:0000921)1.95689809
109Skin tags (HP:0010609)1.94538826
110Neoplasm of striated muscle (HP:0009728)1.94494932
111Abnormality of macrophages (HP:0004311)1.94158466
112Reticulocytosis (HP:0001923)1.94011645
113Progressive external ophthalmoplegia (HP:0000590)1.93208164
114Panhypogammaglobulinemia (HP:0003139)1.92778787
115Short phalanx of the thumb (HP:0009660)1.92191744
116Obstructive sleep apnea (HP:0002870)1.92061604
117Ulnar deviation of the wrist (HP:0003049)1.91582916
118Increased IgM level (HP:0003496)1.90769221
119Muscle stiffness (HP:0003552)1.90405933
120Microretrognathia (HP:0000308)1.89813759
121Purpura (HP:0000979)1.88703322
122Granulocytopenia (HP:0001913)1.88126346
123Abnormal gallbladder physiology (HP:0012438)1.87978521
124Cholecystitis (HP:0001082)1.87978521
125Shallow orbits (HP:0000586)1.86399145
126Short 4th metacarpal (HP:0010044)1.86019602
127Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.86019602
128Thrombocytosis (HP:0001894)1.84089352
129Progressive muscle weakness (HP:0003323)1.82151657
130EMG: neuropathic changes (HP:0003445)1.81935494
131Rhabdomyolysis (HP:0003201)1.81236869
132Megalocornea (HP:0000485)1.79521291
133Preauricular skin tag (HP:0000384)1.79032553
134Oral leukoplakia (HP:0002745)1.78737801
135Sparse lateral eyebrow (HP:0005338)1.78437421
136Lymphopenia (HP:0001888)1.78121368
137Overriding aorta (HP:0002623)1.77891837
138Abnormality of skeletal muscle fiber size (HP:0012084)1.77720804
139Premature skin wrinkling (HP:0100678)1.77603577
140Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.77425028
141Premature ovarian failure (HP:0008209)1.77402783
142Emphysema (HP:0002097)1.77359532
143Recurrent bronchitis (HP:0002837)1.76802727
144Acute hepatic failure (HP:0006554)1.76795684
145Hyperparathyroidism (HP:0000843)1.75969721
146Abnormality of cells of the lymphoid lineage (HP:0012140)1.75484273
147Rough bone trabeculation (HP:0100670)1.75432337
148Self-mutilation (HP:0000742)1.74709917
149Elfin facies (HP:0004428)1.73309586
150Fatigue (HP:0012378)1.72996550
151Rectal prolapse (HP:0002035)1.72230120
152Increased variability in muscle fiber diameter (HP:0003557)1.71974924
153Recurrent fungal infections (HP:0002841)1.70370800
154Overlapping toe (HP:0001845)1.69582896
155Bulbar palsy (HP:0001283)1.69019781
156Gastrointestinal infarctions (HP:0005244)1.68849282
157Abnormal number of incisors (HP:0011064)1.68760350
158Disproportionate tall stature (HP:0001519)1.68569408
159Bowel diverticulosis (HP:0005222)1.68344517
160Hypercortisolism (HP:0001578)1.68341403
161Proximal placement of thumb (HP:0009623)1.66886341
162Aplasia/Hypoplasia of the sacrum (HP:0008517)1.66875531
163Deviation of the thumb (HP:0009603)1.66691663
164Neoplasm of the heart (HP:0100544)1.66433160
165Hypertriglyceridemia (HP:0002155)1.65975860
166Hallux valgus (HP:0001822)1.65562517
167Atresia of the external auditory canal (HP:0000413)1.65087163
168Medulloblastoma (HP:0002885)1.64831563
169Poikiloderma (HP:0001029)1.64583449
170Patellar aplasia (HP:0006443)1.63664942
171Personality changes (HP:0000751)1.63579013
172Abnormality of the fingertips (HP:0001211)1.63339003
173Abnormality of the calcaneus (HP:0008364)1.63229394
174Broad face (HP:0000283)1.62814213
175Pointed chin (HP:0000307)1.62779384
176Macrocytic anemia (HP:0001972)1.62706290
177Elbow flexion contracture (HP:0002987)1.62006515
178Facial hemangioma (HP:0000329)1.61129752
179Increased muscle lipid content (HP:0009058)1.61001219
180Gastrointestinal dysmotility (HP:0002579)1.60700313
181Cafe-au-lait spot (HP:0000957)1.60477371
182Bronchiectasis (HP:0002110)1.60398510
183Spinal muscular atrophy (HP:0007269)1.60275088
184Recurrent otitis media (HP:0000403)1.60005403
185Bowel incontinence (HP:0002607)1.59653080

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK3.89564626
2EEF2K3.80776218
3SMG13.56543829
4PRPF4B3.45001649
5TESK13.41081974
6TRIB33.40596974
7MAP3K103.08610119
8PRKD33.03561280
9NEK22.77968030
10CDK122.74518881
11PKN22.65101620
12IRAK32.59543179
13TAOK22.47735383
14PDK32.44016725
15PDK42.44016725
16TESK22.17096114
17CDC72.14788544
18ERN12.10307330
19ARAF2.05394304
20BUB11.59412851
21MAP3K131.54491770
22BMX1.47955420
23TAOK11.46935496
24MAP3K111.46665816
25TYRO31.42832654
26BCKDK1.39611119
27WEE11.38036962
28MAP4K11.37839017
29TTK1.35855153
30LATS21.34677259
31DYRK1B1.33896696
32IRAK41.33589164
33CDK71.32906211
34MAP3K11.32662060
35SCYL21.28534819
36RIPK41.26669539
37PAK41.25273131
38RPS6KB21.25197974
39DYRK31.24084143
40ALK1.24010728
41STK101.21502871
42CDK41.20172258
43TBK11.14378048
44NEK11.13281592
45MTOR1.12656508
46LRRK21.10243731
47BRAF1.08211952
48MAPKAPK31.07738870
49MAP3K81.07127167
50PAK21.05723891
51PIM21.04777855
52PLK11.01443395
53PDK21.01349686
54NME20.98083574
55RPS6KA40.96847664
56MAP3K30.95156621
57FGFR40.95072822
58VRK20.93661588
59SIK30.91382264
60CHEK20.91080427
61GRK60.89007263
62IRAK20.87632451
63CHEK10.87290666
64TLK10.86711866
65PAK10.86554273
66AURKA0.83699680
67RIPK10.78135261
68DDR20.77889943
69TYK20.77877592
70MAPK120.77158174
71ATR0.76309683
72AURKB0.75927412
73PDGFRA0.75311395
74PASK0.75177315
75TTN0.74574055
76PDPK10.74542993
77BTK0.71844088
78HIPK20.71321754
79CDK80.71224891
80EPHB10.71165254
81STK380.70666621
82PIM10.70612124
83TNK20.70301937
84ILK0.70243582
85CDK60.70165211
86CDK20.68593934
87MARK20.67950766
88PTK2B0.67914151
89JAK30.67446326
90MARK30.66853208
91MAP3K140.66455652
92EPHA20.66265954
93PRKD20.66057271
94RPS6KA10.64035116
95CDC42BPA0.61622992
96FES0.61610997
97KSR20.61123848
98CDK190.60651554
99PTK60.56802852
100BRSK10.56449089
101CDK90.56089280
102SIK10.55648762
103STK30.55525807
104IKBKB0.55336795
105MAPK110.54073743
106SIK20.53286627
107MAP2K60.52272208
108ATM0.51714956
109ZAP700.50487893
110MAP3K60.50328274
111PAK60.50235160
112FLT30.50033135
113AKT20.49468177
114EIF2AK10.48036864
115RAF10.47941940
116RPS6KA20.47021062
117IKBKE0.46071995
118ABL20.44026772
119DAPK30.43112316
120CDK11A0.43046543
121PTK20.41663105
122HCK0.41094747
123RPS6KC10.40472673
124RPS6KL10.40472673
125MAP3K90.40389585
126MAP2K20.39999624
127SYK0.39986119
128MAP2K30.39667848
129RPS6KA60.39436389
130CDK150.38779557
131DAPK10.38643270
132CSK0.37792878
133UHMK10.37540556
134MATK0.35826698
135MOS0.35463066
136CDK10.33082520
137MAPK40.33028385
138MAP3K50.32682514
139CAMKK10.32425991
140MAP3K70.32280119
141CDK180.31829244
142PDK10.31762070
143MAPKAPK20.31613517
144KDR0.29482150
145DMPK0.29088051
146CSNK2A20.27616691

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.94802832
2Mismatch repair_Homo sapiens_hsa034302.90165441
3Ribosome_Homo sapiens_hsa030102.83947380
4RNA transport_Homo sapiens_hsa030132.80846484
5Spliceosome_Homo sapiens_hsa030402.75255476
6Base excision repair_Homo sapiens_hsa034102.63078066
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48286015
8One carbon pool by folate_Homo sapiens_hsa006702.21263366
9mRNA surveillance pathway_Homo sapiens_hsa030152.18922158
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.16698801
11Cell cycle_Homo sapiens_hsa041102.10014232
12Sulfur relay system_Homo sapiens_hsa041222.09422941
13Other glycan degradation_Homo sapiens_hsa005112.05331754
14Cyanoamino acid metabolism_Homo sapiens_hsa004601.81396162
15Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.74977571
16Nucleotide excision repair_Homo sapiens_hsa034201.72999978
17Homologous recombination_Homo sapiens_hsa034401.66809341
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60660834
19Biosynthesis of amino acids_Homo sapiens_hsa012301.52842396
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.51444048
21Osteoclast differentiation_Homo sapiens_hsa043801.45258475
22Bladder cancer_Homo sapiens_hsa052191.41987720
23Fanconi anemia pathway_Homo sapiens_hsa034601.40888107
24p53 signaling pathway_Homo sapiens_hsa041151.38392584
25Pentose phosphate pathway_Homo sapiens_hsa000301.37863629
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.37834011
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.35113477
28mTOR signaling pathway_Homo sapiens_hsa041501.32605250
29Pyrimidine metabolism_Homo sapiens_hsa002401.30351391
30Notch signaling pathway_Homo sapiens_hsa043301.29816029
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27880162
32Chronic myeloid leukemia_Homo sapiens_hsa052201.27325462
33Acute myeloid leukemia_Homo sapiens_hsa052211.26252774
34Selenocompound metabolism_Homo sapiens_hsa004501.25528535
35Oocyte meiosis_Homo sapiens_hsa041141.23927639
36Thyroid cancer_Homo sapiens_hsa052161.22408549
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.20739267
38VEGF signaling pathway_Homo sapiens_hsa043701.18495844
39Leishmaniasis_Homo sapiens_hsa051401.17210118
40Fatty acid biosynthesis_Homo sapiens_hsa000611.16460502
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.14340081
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13199951
43Antigen processing and presentation_Homo sapiens_hsa046121.13092284
44HTLV-I infection_Homo sapiens_hsa051661.12493060
45Viral myocarditis_Homo sapiens_hsa054161.11621063
46Viral carcinogenesis_Homo sapiens_hsa052031.09253189
47RNA degradation_Homo sapiens_hsa030181.08883284
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08706952
49Hedgehog signaling pathway_Homo sapiens_hsa043401.05579281
50Fructose and mannose metabolism_Homo sapiens_hsa000511.05423543
51Basal cell carcinoma_Homo sapiens_hsa052171.03913896
52Measles_Homo sapiens_hsa051621.02331189
53Influenza A_Homo sapiens_hsa051641.01918859
54Small cell lung cancer_Homo sapiens_hsa052221.00779836
55Basal transcription factors_Homo sapiens_hsa030221.00690209
56Prion diseases_Homo sapiens_hsa050200.98329003
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.98133288
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97738220
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96527326
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94223610
61Allograft rejection_Homo sapiens_hsa053300.93758114
62Hepatitis C_Homo sapiens_hsa051600.93210337
63MicroRNAs in cancer_Homo sapiens_hsa052060.92432371
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92112473
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.91518947
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91403123
67TNF signaling pathway_Homo sapiens_hsa046680.90267535
68HIF-1 signaling pathway_Homo sapiens_hsa040660.90260174
69Herpes simplex infection_Homo sapiens_hsa051680.88989040
70Hippo signaling pathway_Homo sapiens_hsa043900.87015381
71Epstein-Barr virus infection_Homo sapiens_hsa051690.86140157
72Glucagon signaling pathway_Homo sapiens_hsa049220.84848113
73Carbon metabolism_Homo sapiens_hsa012000.82883025
74Non-small cell lung cancer_Homo sapiens_hsa052230.80799945
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79126066
76Autoimmune thyroid disease_Homo sapiens_hsa053200.78748309
77Systemic lupus erythematosus_Homo sapiens_hsa053220.77598325
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77446001
79Shigellosis_Homo sapiens_hsa051310.76897465
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75959468
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75759530
82RNA polymerase_Homo sapiens_hsa030200.74809752
83B cell receptor signaling pathway_Homo sapiens_hsa046620.74123303
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74113951
85Tuberculosis_Homo sapiens_hsa051520.72538170
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.72373806
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71677077
88ErbB signaling pathway_Homo sapiens_hsa040120.70410113
89Graft-versus-host disease_Homo sapiens_hsa053320.70212107
90Lysine degradation_Homo sapiens_hsa003100.68255771
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67486075
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66066488
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66006461
94Colorectal cancer_Homo sapiens_hsa052100.65541031
95Salmonella infection_Homo sapiens_hsa051320.65180202
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64544429
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.63569205
98Proteoglycans in cancer_Homo sapiens_hsa052050.63004791
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.61938136
100Apoptosis_Homo sapiens_hsa042100.60937133
101Adherens junction_Homo sapiens_hsa045200.60329430
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59528377
103Endometrial cancer_Homo sapiens_hsa052130.59065839
104AMPK signaling pathway_Homo sapiens_hsa041520.59009702
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58492168
106Galactose metabolism_Homo sapiens_hsa000520.57335021
107Estrogen signaling pathway_Homo sapiens_hsa049150.55977824
108Dorso-ventral axis formation_Homo sapiens_hsa043200.55901044
109Glioma_Homo sapiens_hsa052140.55540499
110Vitamin B6 metabolism_Homo sapiens_hsa007500.55043454
111Renal cell carcinoma_Homo sapiens_hsa052110.54229535
112Hepatitis B_Homo sapiens_hsa051610.53203105
113Insulin signaling pathway_Homo sapiens_hsa049100.52324073
114Wnt signaling pathway_Homo sapiens_hsa043100.51691906
115Phenylalanine metabolism_Homo sapiens_hsa003600.51574308
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51519368
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51179844
118Legionellosis_Homo sapiens_hsa051340.51013170
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50815222
120N-Glycan biosynthesis_Homo sapiens_hsa005100.50806814
121Hematopoietic cell lineage_Homo sapiens_hsa046400.48274430
122Endocytosis_Homo sapiens_hsa041440.46174394
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.46163647
124Primary immunodeficiency_Homo sapiens_hsa053400.45742494
125Folate biosynthesis_Homo sapiens_hsa007900.44243869
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.44181580
127Purine metabolism_Homo sapiens_hsa002300.43667019
128Proteasome_Homo sapiens_hsa030500.43263002
129Pathways in cancer_Homo sapiens_hsa052000.41312882
130Prostate cancer_Homo sapiens_hsa052150.40211866
131Chemokine signaling pathway_Homo sapiens_hsa040620.40208205
132Pancreatic cancer_Homo sapiens_hsa052120.39824873
133Insulin resistance_Homo sapiens_hsa049310.38875482
134T cell receptor signaling pathway_Homo sapiens_hsa046600.38635524
135GnRH signaling pathway_Homo sapiens_hsa049120.38150113
136Non-homologous end-joining_Homo sapiens_hsa034500.37982747
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37789761
138Alcoholism_Homo sapiens_hsa050340.37059667
139Toxoplasmosis_Homo sapiens_hsa051450.36806428
140AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34341126

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