RNF13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. The specific function of this gene has not yet been determined. Alternatively spliced transcript variants that encode the same protein have been reported. A pseudogene, which is also located on chromosome 3, has been defined for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.01521141
2axon ensheathment (GO:0008366)6.24999275
3ensheathment of neurons (GO:0007272)6.24999275
4myelination (GO:0042552)6.23919399
5long-chain fatty acid biosynthetic process (GO:0042759)5.63338117
6myelin maintenance (GO:0043217)5.08746674
7neutrophil activation involved in immune response (GO:0002283)4.89345750
8detection of molecule of bacterial origin (GO:0032490)4.84405784
9cholesterol biosynthetic process (GO:0006695)4.80995630
10negative regulation of neurotransmitter secretion (GO:0046929)4.54010296
11negative regulation of neurotransmitter transport (GO:0051589)4.36215386
12positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.32205037
13long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.27777659
14creatine metabolic process (GO:0006600)4.27474775
15sterol biosynthetic process (GO:0016126)4.26998776
16response to peptidoglycan (GO:0032494)4.23285410
17response to methylmercury (GO:0051597)4.22382000
18glycerophospholipid catabolic process (GO:0046475)4.21128776
19oligodendrocyte differentiation (GO:0048709)4.19224602
20modulation by symbiont of host defense response (GO:0052031)4.18098703
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.18098703
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.18098703
23positive regulation by organism of defense response of other organism involved in symbiotic interact4.18098703
24modulation by symbiont of host immune response (GO:0052553)4.18098703
25positive regulation by symbiont of host defense response (GO:0052509)4.18098703
26macrophage activation involved in immune response (GO:0002281)4.17584462
27negative regulation of interleukin-12 production (GO:0032695)4.16932131
28negative regulation of protein localization to cell surface (GO:2000009)4.11455559
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.09673739
30regulation of collateral sprouting (GO:0048670)4.02754485
31long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.96769986
32L-amino acid import (GO:0043092)3.93471740
33erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.89199410
34L-phenylalanine catabolic process (GO:0006559)3.89199410
35amyloid precursor protein metabolic process (GO:0042982)3.88419489
36establishment of mitochondrion localization (GO:0051654)3.88145085
37fatty-acyl-CoA biosynthetic process (GO:0046949)3.86469510
38microglial cell activation (GO:0001774)3.81605502
39positive regulation of gamma-delta T cell activation (GO:0046645)3.81002360
40positive regulation of oligodendrocyte differentiation (GO:0048714)3.80516741
41detection of external biotic stimulus (GO:0098581)3.77707109
42very long-chain fatty acid metabolic process (GO:0000038)3.76364199
43import into cell (GO:0098657)3.75236392
44positive regulation of cellular amide metabolic process (GO:0034250)3.72491100
45apical protein localization (GO:0045176)3.72442080
46fatty-acyl-CoA metabolic process (GO:0035337)3.72031500
47eye photoreceptor cell differentiation (GO:0001754)3.71886073
48photoreceptor cell differentiation (GO:0046530)3.71886073
49macrophage activation (GO:0042116)3.70702915
50detection of other organism (GO:0098543)3.70032223
51regulation of lipoprotein metabolic process (GO:0050746)3.66104868
52isoprenoid biosynthetic process (GO:0008299)3.65994143
53cellular extravasation (GO:0045123)3.65039602
54response to lipoprotein particle (GO:0055094)3.62299303
55presynaptic membrane organization (GO:0097090)3.59791270
56asymmetric protein localization (GO:0008105)3.56873542
57astrocyte development (GO:0014002)3.55118156
58oligosaccharide catabolic process (GO:0009313)3.54245520
59negative regulation of cell killing (GO:0031342)3.52139788
60negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.52139788
61positive regulation of mast cell activation (GO:0033005)3.49558161
62response to redox state (GO:0051775)3.48933260
63regulation of interferon-beta biosynthetic process (GO:0045357)3.46821619
64cellular response to thyroid hormone stimulus (GO:0097067)3.41247323
65immunoglobulin mediated immune response (GO:0016064)3.40848078
66adhesion of symbiont to host cell (GO:0044650)3.40815051
67virion attachment to host cell (GO:0019062)3.40815051
68regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.39298424
69detection of biotic stimulus (GO:0009595)3.37994629
70neutrophil activation (GO:0042119)3.34939137
71presynaptic membrane assembly (GO:0097105)3.30586979
72positive regulation of mast cell activation involved in immune response (GO:0033008)3.30367756
73positive regulation of mast cell degranulation (GO:0043306)3.30367756
74granulocyte activation (GO:0036230)3.28794312
75positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.27778582
76positive regulation of toll-like receptor signaling pathway (GO:0034123)3.27018245
77erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.26192778
78L-phenylalanine metabolic process (GO:0006558)3.26192778
79glycosphingolipid catabolic process (GO:0046479)3.24962382
80negative regulation of interleukin-17 production (GO:0032700)3.23977630
81heme transport (GO:0015886)3.23397825
82acyl-CoA biosynthetic process (GO:0071616)3.19727682
83thioester biosynthetic process (GO:0035384)3.19727682
84membrane tubulation (GO:0097320)3.18583132
85substantia nigra development (GO:0021762)3.18241675
86amyloid precursor protein catabolic process (GO:0042987)3.17154144
87interferon-gamma-mediated signaling pathway (GO:0060333)3.16240592
88nucleotide transmembrane transport (GO:1901679)3.14544505
89detection of bacterium (GO:0016045)3.07924768
90GPI anchor biosynthetic process (GO:0006506)3.07606756
91GPI anchor metabolic process (GO:0006505)3.05914378
92regulation of mast cell degranulation (GO:0043304)3.05721763
93respiratory burst (GO:0045730)3.04298541
94amino sugar catabolic process (GO:0046348)3.04257210
95iron coordination entity transport (GO:1901678)3.03736553
96T-helper 1 type immune response (GO:0042088)3.03715321
97response to host immune response (GO:0052572)3.03364396
98response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.03364396
99peptidyl-tyrosine autophosphorylation (GO:0038083)3.01969260
100myeloid cell activation involved in immune response (GO:0002275)3.01896303
101positive regulation of leukocyte degranulation (GO:0043302)2.99853476
102regulation of mast cell activation (GO:0033003)2.99437189
103axon development (GO:0061564)2.98636962
104regulation of mast cell activation involved in immune response (GO:0033006)2.98182706
105positive regulation of cellular amine metabolic process (GO:0033240)2.97751836
106antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.96824391
107production of molecular mediator involved in inflammatory response (GO:0002532)2.96799990
108protein palmitoylation (GO:0018345)2.95609359
109regulation of mononuclear cell migration (GO:0071675)2.95518569
110lipopolysaccharide-mediated signaling pathway (GO:0031663)2.95347871
111positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.95342518
112glycolipid catabolic process (GO:0019377)2.93470329
113glycosylceramide metabolic process (GO:0006677)2.89050485
114positive regulation of macrophage cytokine production (GO:0060907)2.88626497
115myelination in peripheral nervous system (GO:0022011)2.87682879
116peripheral nervous system axon ensheathment (GO:0032292)2.87682879
117amino acid import (GO:0043090)2.85259585
118neutrophil mediated immunity (GO:0002446)2.84751807
119magnesium ion transport (GO:0015693)2.83789214
120antigen processing and presentation of endogenous antigen (GO:0019883)2.83497951
121positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.81308484
122neutrophil chemotaxis (GO:0030593)2.80940095
123adult walking behavior (GO:0007628)2.79147757
124cellular response to ethanol (GO:0071361)2.77202903
125regulation of gamma-delta T cell activation (GO:0046643)2.74261129
126neutrophil migration (GO:1990266)2.73794589
127negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.73010944
128negative regulation of JUN kinase activity (GO:0043508)2.72220248
129neuron remodeling (GO:0016322)2.70217792
130negative regulation of acute inflammatory response (GO:0002674)2.69522721
131ceramide catabolic process (GO:0046514)2.69304048
132antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.69115784
133regulation of B cell receptor signaling pathway (GO:0050855)2.68914693
134leukocyte migration involved in inflammatory response (GO:0002523)2.68082830
135phagosome maturation (GO:0090382)2.67940882
136cellular response to type I interferon (GO:0071357)2.65411646
137type I interferon signaling pathway (GO:0060337)2.65411646
138regulation of macrophage chemotaxis (GO:0010758)2.65224364
139regulation of interferon-alpha production (GO:0032647)2.65088409
140granulocyte chemotaxis (GO:0071621)2.64466330
141regulation of interleukin-8 biosynthetic process (GO:0045414)2.63158180
142regulation of podosome assembly (GO:0071801)2.62779581
143B cell mediated immunity (GO:0019724)2.62216523
144adhesion of symbiont to host (GO:0044406)2.62114286
145neurotransmitter uptake (GO:0001504)2.61099863
146regulation of leukocyte degranulation (GO:0043300)2.60718029
147negative regulation of lipid storage (GO:0010888)2.59970854
148defense response to protozoan (GO:0042832)2.59771745
149response to lead ion (GO:0010288)2.59584969
150response to type I interferon (GO:0034340)2.59236059
151regulation of myeloid leukocyte mediated immunity (GO:0002886)2.58552770
152response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.57532794
153response to host (GO:0075136)2.57532794
154response to host defenses (GO:0052200)2.57532794
155positive regulation of interferon-alpha production (GO:0032727)2.56929610
156nucleotide transport (GO:0006862)2.55223999
157myeloid leukocyte activation (GO:0002274)2.55125644
158acyl-CoA metabolic process (GO:0006637)2.54822405
159thioester metabolic process (GO:0035383)2.54822405
160positive regulation of glial cell differentiation (GO:0045687)2.54806204
161regulation of T-helper 2 cell differentiation (GO:0045628)2.54324607
162preassembly of GPI anchor in ER membrane (GO:0016254)2.54236399
163regulation of beta-amyloid formation (GO:1902003)2.53965084
164peptidyl-cysteine modification (GO:0018198)2.52821720
165granulocyte migration (GO:0097530)2.52710734
166regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.52249087
167regulation of macrophage cytokine production (GO:0010935)2.52085650
168cholesterol metabolic process (GO:0008203)2.51836406
169glutathione biosynthetic process (GO:0006750)2.51804113
170negative regulation of macroautophagy (GO:0016242)2.51074848
171negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.51000260
172superoxide anion generation (GO:0042554)2.49597784
173positive regulation of type 2 immune response (GO:0002830)2.49262523
174positive regulation of interleukin-6 production (GO:0032755)2.48523634
175limb bud formation (GO:0060174)2.47296595
176cerebral cortex radially oriented cell migration (GO:0021799)2.45860776
177regulation of T cell tolerance induction (GO:0002664)2.45700144
178negative regulation of axonogenesis (GO:0050771)2.44674474
179myeloid leukocyte mediated immunity (GO:0002444)2.44594488
180glial cell development (GO:0021782)2.44225751
181hydrogen peroxide biosynthetic process (GO:0050665)2.43950081
182positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.43733722
183negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.43508045
184membrane raft organization (GO:0031579)2.42910794
185protein neddylation (GO:0045116)2.42807619
186positive regulation of action potential (GO:0045760)2.42712834
187neuron cell-cell adhesion (GO:0007158)2.40378991
188tissue regeneration (GO:0042246)2.39929397
189nonribosomal peptide biosynthetic process (GO:0019184)2.39837919
190negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.39050800
191response to dietary excess (GO:0002021)2.36487286
192peripheral nervous system development (GO:0007422)2.36112286
193mannosylation (GO:0097502)2.34801713
194positive regulation of gliogenesis (GO:0014015)2.34186134
195cofactor catabolic process (GO:0051187)2.33994478
196nerve growth factor signaling pathway (GO:0038180)2.32744614
197sterol metabolic process (GO:0016125)2.32319044
198axon ensheathment in central nervous system (GO:0032291)11.1188781
199central nervous system myelination (GO:0022010)11.1188781

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.61787224
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.12169355
3* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.41156613
4* IRF8_27001747_Chip-Seq_BMDM_Mouse3.39370971
5GBX2_23144817_ChIP-Seq_PC3_Human3.21976504
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.18299170
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.94144801
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.74603724
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.63898984
10SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.61487256
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.49907632
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.48033978
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.44901453
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.41174472
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.40672749
16TAF15_26573619_Chip-Seq_HEK293_Human2.39228500
17* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.31398284
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.28358796
19VDR_24787735_ChIP-Seq_THP-1_Human2.16889844
20GATA1_22025678_ChIP-Seq_K562_Human2.01046515
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.00963081
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.98597756
23* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.96731678
24PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.96051431
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95761888
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91646779
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.88389903
28ER_23166858_ChIP-Seq_MCF-7_Human1.80131677
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.75103229
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.74636691
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73318471
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73155501
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.69412134
34AR_21572438_ChIP-Seq_LNCaP_Human1.68713057
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68036162
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67761470
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64642556
38VDR_22108803_ChIP-Seq_LS180_Human1.64517588
39SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.63526293
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.62269372
41RUNX_20019798_ChIP-Seq_JUKART_Human1.61895588
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61700161
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61150575
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58051965
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58051965
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.57745631
47* SPI1_23547873_ChIP-Seq_NB4_Human1.57389661
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.57105625
49SPI1_23127762_ChIP-Seq_K562_Human1.55835676
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.54288961
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.54288961
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.54089347
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.52153084
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47202801
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46414310
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.46080726
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.44266828
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.43990686
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40232771
60PU_27001747_Chip-Seq_BMDM_Mouse1.38328083
61FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35252688
62CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.35050456
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32745795
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31896317
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30379826
66FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29034103
67P300_19829295_ChIP-Seq_ESCs_Human1.28001387
68HTT_18923047_ChIP-ChIP_STHdh_Human1.27833609
69STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.27755919
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27601414
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26713451
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25050832
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24313294
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24028706
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23830121
76EZH2_22144423_ChIP-Seq_EOC_Human1.22377719
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22184370
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.20944452
79DROSHA_22980978_ChIP-Seq_HELA_Human1.20383316
80RNF2_27304074_Chip-Seq_ESCs_Mouse1.20024481
81STAT4_19710469_ChIP-ChIP_TH1__Mouse1.19713193
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.19673736
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17997915
84SCL_19346495_ChIP-Seq_HPC-7_Human1.17441055
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17136031
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17122969
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16871957
88CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16852669
89ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.16540886
90FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16516174
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16323762
92TAL1_26923725_Chip-Seq_HPCs_Mouse1.14978948
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11041825
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10377954
95SOX2_20726797_ChIP-Seq_SW620_Human1.09847321
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.09845632
97GATA3_26560356_Chip-Seq_TH2_Human1.09622738
98FUS_26573619_Chip-Seq_HEK293_Human1.09384668
99EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09256276
100BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08958224
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08828975
102* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08579592
103LXR_22158963_ChIP-Seq_LIVER_Mouse1.08281217
104NFE2_27457419_Chip-Seq_LIVER_Mouse1.06025370
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05981163
106TRIM28_21343339_ChIP-Seq_HEK293_Human1.05720377
107MYB_26560356_Chip-Seq_TH2_Human1.04858188
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.04763767
109GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04552128
110CRX_20693478_ChIP-Seq_RETINA_Mouse1.04471584
111EOMES_21245162_ChIP-Seq_HESCs_Human1.04373701
112SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03723232
113CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03233703
114EP300_21415370_ChIP-Seq_HL-1_Mouse1.03183743
115P300_18555785_Chip-Seq_ESCs_Mouse1.02936315
116LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01820011
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01165882
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01164568
119STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00357113
120TFEB_21752829_ChIP-Seq_HELA_Human0.99964969
121ESR1_20079471_ChIP-ChIP_T-47D_Human0.99953640
122BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99848639
123* STAT3_23295773_ChIP-Seq_U87_Human0.99689947
124OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99671761
125SOX2_19829295_ChIP-Seq_ESCs_Human0.99475600
126NANOG_19829295_ChIP-Seq_ESCs_Human0.99475600
127BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99450987
128TP63_23658742_ChIP-Seq_EP156T_Human0.99234756
129GATA3_27048872_Chip-Seq_THYMUS_Human0.98372058
130TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98243177
131E2F1_18555785_Chip-Seq_ESCs_Mouse0.97757809
132FLI1_27457419_Chip-Seq_LIVER_Mouse0.97471232
133SMAD4_21799915_ChIP-Seq_A2780_Human0.97440510
134MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97230116
135TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96585668
136PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96503068
137PRDM14_20953172_ChIP-Seq_ESCs_Human0.96294481
138ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95830626
139ARNT_22903824_ChIP-Seq_MCF-7_Human0.95579051
140LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95512152
141EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95300880
142NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95051238
143BCAT_22108803_ChIP-Seq_LS180_Human0.94607433
144ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93575964
145CJUN_26792858_Chip-Seq_BT549_Human0.93573128
146P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92835148
147AHR_22903824_ChIP-Seq_MCF-7_Human0.92735105
148SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91636628
149SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91125316
150SMRT_27268052_Chip-Seq_Bcells_Human0.90897189
151PU1_27457419_Chip-Seq_LIVER_Mouse0.90829172
152GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90210814
153SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89615239
154NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89379644
155KDM2B_26808549_Chip-Seq_REH_Human0.89088644
156EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.88460876
157CDX2_22108803_ChIP-Seq_LS180_Human0.87435446
158* SALL4_22934838_ChIP-ChIP_CD34+_Human0.87405748
159NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87278065
160SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.87059756
161PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86895265
162P53_22387025_ChIP-Seq_ESCs_Mouse0.86881672
163RUNX1_27457419_Chip-Seq_LIVER_Mouse0.86876364
164FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.86778022
165SMAD1_18555785_Chip-Seq_ESCs_Mouse0.86320929
166TP53_18474530_ChIP-ChIP_U2OS_Human0.86189551
167EZH2_27294783_Chip-Seq_NPCs_Mouse0.86136342

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.56899701
2MP0003724_increased_susceptibility_to4.47633632
3MP0003950_abnormal_plasma_membrane3.84912630
4MP0003303_peritoneal_inflammation3.67535383
5MP0003690_abnormal_glial_cell3.58216320
6MP0003880_abnormal_central_pattern3.26482695
7MP0003191_abnormal_cellular_cholesterol3.17964133
8MP0001835_abnormal_antigen_presentation3.00005150
9MP0003329_amyloid_beta_deposits2.78523102
10MP0009785_altered_susceptibility_to2.69239662
11MP0003806_abnormal_nucleotide_metabolis2.65268013
12MP0004270_analgesia2.64557301
13MP0002419_abnormal_innate_immunity2.62653444
14MP0003436_decreased_susceptibility_to2.59007167
15MP0003172_abnormal_lysosome_physiology2.55843425
16MP0005171_absent_coat_pigmentation2.54831119
17MP0002148_abnormal_hypersensitivity_rea2.49477716
18MP0004885_abnormal_endolymph2.44027862
19MP0001529_abnormal_vocalization2.43824383
20MP0003136_yellow_coat_color2.39232159
21MP0003634_abnormal_glial_cell2.35322362
22MP0003300_gastrointestinal_ulcer2.32701399
23MP0000569_abnormal_digit_pigmentation2.26992936
24MP0001905_abnormal_dopamine_level2.26980014
25MP0005671_abnormal_response_to2.20826010
26MP0004142_abnormal_muscle_tone2.17335131
27MP0004742_abnormal_vestibular_system2.14938143
28MP0005000_abnormal_immune_tolerance2.13859083
29MP0001486_abnormal_startle_reflex2.13466606
30MP0002272_abnormal_nervous_system2.12793676
31MP0005387_immune_system_phenotype2.11149116
32MP0001790_abnormal_immune_system2.11149116
33MP0005167_abnormal_blood-brain_barrier2.08062414
34MP0005025_abnormal_response_to2.06569998
35MP0004043_abnormal_pH_regulation2.01060081
36MP0003195_calcinosis2.00578500
37MP0002064_seizures1.88999681
38MP0002452_abnormal_antigen_presenting1.87832923
39MP0005451_abnormal_body_composition1.85740975
40MP0000604_amyloidosis1.85086466
41MP0009764_decreased_sensitivity_to1.83831885
42MP0005409_darkened_coat_color1.82910644
43MP0000685_abnormal_immune_system1.82885824
44MP0002723_abnormal_immune_serum1.82103499
45MP0005058_abnormal_lysosome_morphology1.81298725
46MP0001533_abnormal_skeleton_physiology1.79599025
47MP0002229_neurodegeneration1.78589558
48MP0001800_abnormal_humoral_immune1.77093709
49MP0003632_abnormal_nervous_system1.73481266
50MP0003183_abnormal_peptide_metabolism1.71325161
51MP0000343_altered_response_to1.70040023
52MP0009840_abnormal_foam_cell1.68634769
53MP0005410_abnormal_fertilization1.66761361
54MP0001485_abnormal_pinna_reflex1.64646814
55MP0004381_abnormal_hair_follicle1.61225249
56MP0010678_abnormal_skin_adnexa1.61089849
57MP0001845_abnormal_inflammatory_respons1.57466028
58MP0002420_abnormal_adaptive_immunity1.56682450
59MP0001819_abnormal_immune_cell1.55575488
60MP0005464_abnormal_platelet_physiology1.52477998
61MP0000778_abnormal_nervous_system1.52080280
62MP0000383_abnormal_hair_follicle1.50230125
63MP0004883_abnormal_blood_vessel1.49695871
64MP0000465_gastrointestinal_hemorrhage1.49401723
65MP0008260_abnormal_autophagy1.48272789
66MP0005551_abnormal_eye_electrophysiolog1.46607281
67MP0009046_muscle_twitch1.45245546
68MP0003631_nervous_system_phenotype1.42549499
69MP0006054_spinal_hemorrhage1.42365064
70MP0008875_abnormal_xenobiotic_pharmacok1.40786223
71MP0003828_pulmonary_edema1.40560588
72MP0002405_respiratory_system_inflammati1.39939827
73MP0005423_abnormal_somatic_nervous1.38460439
74MP0010234_abnormal_vibrissa_follicle1.38016342
75MP0003633_abnormal_nervous_system1.35188622
76MP0008469_abnormal_protein_level1.34984529
77MP0009745_abnormal_behavioral_response1.34613637
78MP0004147_increased_porphyrin_level1.33734955
79MP0005248_abnormal_Harderian_gland1.32965754
80MP0005166_decreased_susceptibility_to1.32116681
81MP0002734_abnormal_mechanical_nocicepti1.30998881
82MP0002998_abnormal_bone_remodeling1.30475154
83MP0002139_abnormal_hepatobiliary_system1.29148251
84MP0001661_extended_life_span1.28931025
85MP0005360_urolithiasis1.26273550
86MP0006082_CNS_inflammation1.24343849
87MP0004134_abnormal_chest_morphology1.21800710
88MP0000566_synostosis1.20786219
89MP0000462_abnormal_digestive_system1.20728157
90MP0003635_abnormal_synaptic_transmissio1.18657993
91MP0001853_heart_inflammation1.18639377
92MP0010155_abnormal_intestine_physiology1.16544257
93MP0003448_altered_tumor_morphology1.16338485
94MP0004859_abnormal_synaptic_plasticity1.15582545
95MP0005310_abnormal_salivary_gland1.14626785
96MP0001440_abnormal_grooming_behavior1.10230614
97MP0001346_abnormal_lacrimal_gland1.08819168
98MP0002254_reproductive_system_inflammat1.06794063
99MP0000955_abnormal_spinal_cord1.03772871
100MP0001963_abnormal_hearing_physiology1.03060444
101MP0005332_abnormal_amino_acid1.02654014
102MP0004947_skin_inflammation1.02476808
103MP0001851_eye_inflammation1.02060010
104MP0002572_abnormal_emotion/affect_behav1.01621595
105MP0005408_hypopigmentation1.01561045
106MP0002882_abnormal_neuron_morphology1.00704359
107MP0002066_abnormal_motor_capabilities/c1.00693409
108MP0001545_abnormal_hematopoietic_system0.99463541
109MP0005397_hematopoietic_system_phenotyp0.99463541
110MP0000371_diluted_coat_color0.99090118
111MP0002295_abnormal_pulmonary_circulatio0.98207087
112MP0000716_abnormal_immune_system0.97814996
113MP0000747_muscle_weakness0.97557166
114MP0001970_abnormal_pain_threshold0.97381918
115MP0008569_lethality_at_weaning0.97283510
116MP0005195_abnormal_posterior_eye0.96935253
117MP0002277_abnormal_respiratory_mucosa0.96391610
118MP0008004_abnormal_stomach_pH0.96346187
119MP0002090_abnormal_vision0.96236341
120MP0004510_myositis0.95356680
121MP0005386_behavior/neurological_phenoty0.94484853
122MP0004924_abnormal_behavior0.94484853
123MP0008438_abnormal_cutaneous_collagen0.94033541
124MP0000647_abnormal_sebaceous_gland0.93836819
125MP0002118_abnormal_lipid_homeostasis0.93560094
126MP0002067_abnormal_sensory_capabilities0.93108541
127MP0003656_abnormal_erythrocyte_physiolo0.92680971
128MP0001177_atelectasis0.90280893
129MP0003011_delayed_dark_adaptation0.89695795
130MP0005085_abnormal_gallbladder_physiolo0.88899873
131MP0005584_abnormal_enzyme/coenzyme_acti0.87782050
132MP0002063_abnormal_learning/memory/cond0.85195021
133MP0002752_abnormal_somatic_nervous0.84962526
134MP0002332_abnormal_exercise_endurance0.84599943
135MP0003075_altered_response_to0.83387293
136MP0001299_abnormal_eye_distance/0.81657038
137MP0009763_increased_sensitivity_to0.80651496
138MP0010386_abnormal_urinary_bladder0.78430775
139MP0005075_abnormal_melanosome_morpholog0.78426832
140MP0000015_abnormal_ear_pigmentation0.77379373
141MP0004484_altered_response_of0.76629283
142MP0000579_abnormal_nail_morphology0.76289753
143MP0005174_abnormal_tail_pigmentation0.75759071
144MP0001324_abnormal_eye_pigmentation0.75469744
145MP0000249_abnormal_blood_vessel0.75242227
146MP0000689_abnormal_spleen_morphology0.74960930
147MP0000372_irregular_coat_pigmentation0.74311062
148MP0002166_altered_tumor_susceptibility0.73876397
149MP0000858_altered_metastatic_potential0.71123812
150MP0004036_abnormal_muscle_relaxation0.69363177
151MP0005535_abnormal_body_temperature0.69163448
152MP0005623_abnormal_meninges_morphology0.67985074
153MP0002733_abnormal_thermal_nociception0.66872114
154MP0002398_abnormal_bone_marrow0.65489211
155MP0002133_abnormal_respiratory_system0.65483669
156MP0005388_respiratory_system_phenotype0.65483669
157MP0003866_abnormal_defecation0.65369555
158MP0005165_increased_susceptibility_to0.64836106
159MP0002736_abnormal_nociception_after0.64687141
160MP0005253_abnormal_eye_physiology0.64432900
161MP0005376_homeostasis/metabolism_phenot0.64278304
162MP0005083_abnormal_biliary_tract0.62832456
163MP0002429_abnormal_blood_cell0.62558567
164MP0001968_abnormal_touch/_nociception0.62520627
165MP0002971_abnormal_brown_adipose0.60897440
166MP0005164_abnormal_response_to0.59100774
167MP0000762_abnormal_tongue_morphology0.58946507
168MP0000639_abnormal_adrenal_gland0.58550495
169MP0005365_abnormal_bile_salt0.58311033
170MP0000026_abnormal_inner_ear0.58128125
171MP0001502_abnormal_circadian_rhythm0.57371847

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)6.57739621
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.29455500
3Degeneration of the lateral corticospinal tracts (HP:0002314)6.29455500
4Abnormality of liposaccharide metabolism (HP:0010968)6.26397485
5Abnormality of glycosphingolipid metabolism (HP:0004343)6.26397485
6Abnormality of glycolipid metabolism (HP:0010969)6.26397485
7Abnormality of macrophages (HP:0004311)4.85962509
8Recurrent bacterial skin infections (HP:0005406)4.79940146
9Eczematoid dermatitis (HP:0000976)4.69433643
10Cerebral inclusion bodies (HP:0100314)4.63088353
11Abnormality of the corticospinal tract (HP:0002492)4.60277110
12Recurrent abscess formation (HP:0002722)4.59609710
13Parakeratosis (HP:0001036)4.58454681
14Vacuolated lymphocytes (HP:0001922)4.20584289
15Recurrent gram-negative bacterial infections (HP:0005420)4.14448902
16Sensory axonal neuropathy (HP:0003390)4.13134799
17Peripheral hypomyelination (HP:0007182)3.90859622
18Retrobulbar optic neuritis (HP:0100654)3.85875394
19Optic neuritis (HP:0100653)3.85875394
20Stomatitis (HP:0010280)3.82398278
21Orchitis (HP:0100796)3.81898215
22Increased cerebral lipofuscin (HP:0011813)3.69657860
23Onion bulb formation (HP:0003383)3.61561852
24Myositis (HP:0100614)3.60877234
25Disinhibition (HP:0000734)3.60844659
26Systemic lupus erythematosus (HP:0002725)3.55725566
27Dysostosis multiplex (HP:0000943)3.54164701
28Supranuclear gaze palsy (HP:0000605)3.52943662
29Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.50021906
30Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.31283369
31Increased serum pyruvate (HP:0003542)3.27545908
32Abnormality of glycolysis (HP:0004366)3.27545908
33Abnormal auditory evoked potentials (HP:0006958)3.20444071
34Spastic gait (HP:0002064)3.16723397
35Insidious onset (HP:0003587)3.07457137
36Termporal pattern (HP:0011008)3.07457137
37Mediastinal lymphadenopathy (HP:0100721)3.06839570
38Intention tremor (HP:0002080)3.05368367
39Recurrent skin infections (HP:0001581)3.03443199
40Abnormality of aromatic amino acid family metabolism (HP:0004338)3.00187799
41Mutism (HP:0002300)2.97077600
42Cerebral hypomyelination (HP:0006808)2.93249635
43Increased CSF protein (HP:0002922)2.88098755
44Leukodystrophy (HP:0002415)2.87845725
45Dysmetria (HP:0001310)2.84335835
46Abnormality of mucopolysaccharide metabolism (HP:0011020)2.82195138
47Abnormality of polysaccharide metabolism (HP:0011012)2.82195138
48Abnormality of glycosaminoglycan metabolism (HP:0004371)2.82195138
49Axonal loss (HP:0003447)2.80010936
50Urinary glycosaminoglycan excretion (HP:0003541)2.77124479
51Mucopolysacchariduria (HP:0008155)2.77124479
52Congenital ichthyosiform erythroderma (HP:0007431)2.71935482
53Cerebral hemorrhage (HP:0001342)2.70923717
54Segmental peripheral demyelination/remyelination (HP:0003481)2.68562115
55Alacrima (HP:0000522)2.67344839
56Spastic paraparesis (HP:0002313)2.67277057
57Hematochezia (HP:0002573)2.66982854
58Autoamputation (HP:0001218)2.66819745
59Hepatosplenomegaly (HP:0001433)2.66418333
60Clumsiness (HP:0002312)2.65632897
61Slow saccadic eye movements (HP:0000514)2.65519490
62Keratoconjunctivitis sicca (HP:0001097)2.64801555
63Pulmonary infiltrates (HP:0002113)2.62814514
64Scanning speech (HP:0002168)2.59657329
65Gingivitis (HP:0000230)2.57828345
66T lymphocytopenia (HP:0005403)2.55449323
67Myocardial infarction (HP:0001658)2.52798064
68Retinal dysplasia (HP:0007973)2.51370971
69Glomerulonephritis (HP:0000099)2.45052824
70Recurrent fungal infections (HP:0002841)2.44134420
71Spontaneous hematomas (HP:0007420)2.43426263
72Keratoconjunctivitis (HP:0001096)2.42770050
73Intrahepatic cholestasis (HP:0001406)2.41818976
74Stridor (HP:0010307)2.41267511
75Ankle clonus (HP:0011448)2.40764479
76Methylmalonic acidemia (HP:0002912)2.39743433
77Akinesia (HP:0002304)2.39029517
78Metabolic alkalosis (HP:0200114)2.38163607
79Thickened helices (HP:0000391)2.37388341
80Gingival bleeding (HP:0000225)2.34727809
81Hemoptysis (HP:0002105)2.33285413
82Abnormality of T cell number (HP:0011839)2.33087546
83Purpura (HP:0000979)2.30381604
84Global brain atrophy (HP:0002283)2.30274655
85Anteriorly placed anus (HP:0001545)2.29123343
86Myokymia (HP:0002411)2.27055352
87Hypokalemic alkalosis (HP:0001949)2.26857406
88Hypoplastic pelvis (HP:0008839)2.24654758
89Hypophosphatemic rickets (HP:0004912)2.23888790
90Increased circulating renin level (HP:0000848)2.23411340
91Agnosia (HP:0010524)2.22394801
92Urticaria (HP:0001025)2.22235770
93Abnormality of the vasculature of the conjunctiva (HP:0008054)2.21871911
94Spastic tetraparesis (HP:0001285)2.21869004
95Patchy hypopigmentation of hair (HP:0011365)2.21626033
96Pulmonary embolism (HP:0002204)2.21414513
97Pheochromocytoma (HP:0002666)2.20478167
98Diminished motivation (HP:0000745)2.19265308
99Hyperlipoproteinemia (HP:0010980)2.19109323
100Apathy (HP:0000741)2.18576230
101Absent septum pellucidum (HP:0001331)2.17765427
102White forelock (HP:0002211)2.17000556
103Chronic obstructive pulmonary disease (HP:0006510)2.16776487
104Obstructive lung disease (HP:0006536)2.16776487
105Albinism (HP:0001022)2.16742782
106Elevated erythrocyte sedimentation rate (HP:0003565)2.16427977
107Premature skin wrinkling (HP:0100678)2.14565795
108Inappropriate behavior (HP:0000719)2.14252693
109Renal Fanconi syndrome (HP:0001994)2.13943697
110Paraparesis (HP:0002385)2.12932869
111Humeroradial synostosis (HP:0003041)2.12455382
112Synostosis involving the elbow (HP:0003938)2.12455382
113Infantile muscular hypotonia (HP:0008947)2.09839728
114Hypomagnesemia (HP:0002917)2.09110300
115Polyneuropathy (HP:0001271)2.08624941
116Autoimmune thrombocytopenia (HP:0001973)2.08526403
117Abnormality of the phalanges of the 2nd finger (HP:0009541)2.08204539
118Split foot (HP:0001839)2.07446684
119Aplasia involving bones of the extremities (HP:0009825)2.07156188
120Aplasia involving bones of the upper limbs (HP:0009823)2.07156188
121Aplasia of the phalanges of the hand (HP:0009802)2.07156188
122Arterial thrombosis (HP:0004420)2.05861201
123Episodic fever (HP:0001954)2.05505297
124Petechiae (HP:0000967)2.05449708
125Decreased lacrimation (HP:0000633)2.05205584
126Basal ganglia calcification (HP:0002135)2.04034911
127Prolonged neonatal jaundice (HP:0006579)2.03643490
128Coronal craniosynostosis (HP:0004440)2.02733929
129Abnormality of the periventricular white matter (HP:0002518)2.02164932
130CNS hypomyelination (HP:0003429)2.00858549
131Peripheral demyelination (HP:0011096)2.00013363
132Gangrene (HP:0100758)1.98796391
133Hypoplasia of the iris (HP:0007676)1.98086644
134Gastrointestinal infarctions (HP:0005244)1.97584835
135Vasculitis (HP:0002633)1.97154145
136Lower limb muscle weakness (HP:0007340)1.95565535
137Neuroendocrine neoplasm (HP:0100634)1.94555421
138Amyloidosis (HP:0011034)1.92998917
139Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.92618426
140Interstitial pulmonary disease (HP:0006530)1.92499571
141Chronic mucocutaneous candidiasis (HP:0002728)1.92374925
142Recurrent cutaneous fungal infections (HP:0011370)1.92374925
1433-Methylglutaconic aciduria (HP:0003535)1.92152195
144Papillary thyroid carcinoma (HP:0002895)1.91623514
145Morphological abnormality of the inner ear (HP:0011390)1.91503007
146Chest pain (HP:0100749)1.88944270
147Foot dorsiflexor weakness (HP:0009027)1.87444011
148Urinary incontinence (HP:0000020)1.86114040
149Abnormality of methionine metabolism (HP:0010901)1.85860170
150Muscle fiber splitting (HP:0003555)1.85847351
151Abnormality of the middle phalanges of the toes (HP:0010183)1.85174011
152Meningitis (HP:0001287)1.84646531
153Erythroderma (HP:0001019)1.84079708
154Vertigo (HP:0002321)1.83377656
155Neuronal loss in central nervous system (HP:0002529)1.83036411
156Progressive neurologic deterioration (HP:0002344)1.82793355
157Osteomyelitis (HP:0002754)1.81524580
158Memory impairment (HP:0002354)1.81421888
159Abnormality of the septum pellucidum (HP:0007375)1.79448535
160Encephalitis (HP:0002383)1.79001859
161Abnormality of the basal ganglia (HP:0002134)1.78567541
162Dementia (HP:0000726)1.77894527
163Megalencephaly (HP:0001355)1.77509884
164Poor speech (HP:0002465)1.77187031
165Decreased motor nerve conduction velocity (HP:0003431)1.76001554
166Acute encephalopathy (HP:0006846)1.74161964
167Anorexia (HP:0002039)1.74017440
168Lower limb hyperreflexia (HP:0002395)1.73883570
169Loss of speech (HP:0002371)1.73325018
170Xanthomatosis (HP:0000991)1.73291606
171Complement deficiency (HP:0004431)1.73002603
172Acute necrotizing encephalopathy (HP:0006965)1.71519061
173Premature loss of primary teeth (HP:0006323)1.70966207
174Morphological abnormality of the pyramidal tract (HP:0002062)1.69961442
175Steatorrhea (HP:0002570)1.69331158
176Clonus (HP:0002169)1.69261256
177Choreoathetosis (HP:0001266)1.69104778
178Prolonged bleeding time (HP:0003010)1.69036307
179Abolished electroretinogram (ERG) (HP:0000550)1.68328829
180Gowers sign (HP:0003391)1.68095488
181Increased neuronal autofluorescent lipopigment (HP:0002074)1.67131081
182Choroideremia (HP:0001139)1.66726626
183Asymmetric septal hypertrophy (HP:0001670)1.65056363
184Mucosal telangiectasiae (HP:0100579)1.63488285
185Action tremor (HP:0002345)1.63017482
186Leukocytosis (HP:0001974)1.62681079
187Joint swelling (HP:0001386)1.61607625

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.22299709
2OXSR14.58842563
3EPHB13.40801002
4RIPK43.17420894
5PBK2.92115795
6TYK22.80531365
7PKN12.70278201
8MAPKAPK52.63068796
9BCR2.61266206
10ACVR1B2.60883990
11FRK2.57379257
12WNK42.51489333
13IRAK42.49950855
14MET2.47761751
15FGFR22.34162788
16CDK192.13731593
17MAP3K142.07613622
18WNK12.01465554
19LIMK11.98204933
20JAK11.86128141
21MAP3K21.81841532
22NEK61.81505951
23TGFBR21.80460224
24MAP3K31.79728686
25CAMKK21.78310312
26CSNK1G31.76617131
27CSNK1A1L1.70957029
28MST41.65439621
29CAMK2B1.55743444
30FGR1.51484607
31CASK1.48885627
32TBK11.48695230
33YES11.47753040
34IKBKE1.47514222
35TXK1.47220875
36UHMK11.45814095
37IRAK31.40725091
38PRPF4B1.40666622
39CSNK1G11.40656637
40MAP3K121.39856519
41CLK11.39797991
42ROCK21.39453126
43NTRK11.38664491
44JAK21.38305837
45MAP2K31.37148741
46PNCK1.37129931
47JAK31.36292899
48TNIK1.35950128
49CAMK2D1.33861795
50SGK4941.33437072
51SGK2231.33437072
52TESK21.31624532
53CSNK1G21.30971123
54MATK1.30713025
55ERBB31.27859267
56ZAP701.27090725
57TAOK31.24798205
58TNK21.20448636
59FER1.20157160
60LYN1.19951646
61MAP3K11.13256662
62HCK1.11977556
63EPHA41.11879907
64EIF2AK31.11679165
65EPHA31.10934103
66IKBKB1.08925215
67CAMK2G1.07839104
68SYK1.06207822
69STK241.05795175
70MAPK151.05556651
71TEC1.05304525
72PAK61.02061536
73TAOK11.01390014
74ICK0.97364364
75PIK3CG0.96083328
76MARK30.95669016
77MAP4K10.94954862
78TIE10.93716122
79PRKCQ0.90042940
80FGFR30.88812204
81DDR20.88255773
82MAP3K50.87436143
83NEK90.87037659
84KIT0.87004950
85ERBB40.86606074
86BMPR1B0.86604481
87CAMK2A0.85627436
88TRPM70.84840605
89ARAF0.81010646
90DYRK20.79195889
91BTK0.78544902
92GRK70.76617718
93TAOK20.76096243
94PRKD10.75756140
95NLK0.75311057
96MUSK0.75257572
97MAP2K60.74459968
98PHKG10.74202853
99PHKG20.74202853
100PRKCE0.74081045
101PDPK10.73023260
102IRAK20.72058798
103CDK50.72004140
104CDK140.71434898
105PAK30.69446654
106MARK20.66900467
107MARK10.66553555
108SGK20.64704252
109DAPK20.64575471
110GRK60.64497251
111ADRBK20.64198211
112NTRK30.63474840
113CDK150.62702636
114ABL10.61332342
115RPS6KA50.60569960
116CAMK1G0.57388524
117CDK180.57319283
118ERN10.57162573
119FYN0.56062258
120MAP3K130.55694610
121PRKG10.53553565
122SGK30.53491154
123CDK11A0.53474638
124ITK0.52361239
125KSR20.52154592
126WNK30.52103106
127PIK3CA0.51567486
128EGFR0.51563063
129PRKAA20.51507724
130CSF1R0.50572617
131SIK30.50262926
132GSK3A0.48861634
133PRKCH0.47196464
134MAPK70.46865609
135BCKDK0.46329524
136PRKACB0.45989881
137CDK60.44889809
138MAPK130.44710026
139CSNK1D0.44475158
140CSNK1A10.40754490
141TYRO30.39342354
142STK100.39192339
143INSRR0.38944231
144BMPR20.37250145
145GRK10.37056397
146RAF10.36484791
147MAP4K20.36290181
148PDK10.35981141
149OBSCN0.35863437
150BMX0.35158870
151IRAK10.34756986
152PTK2B0.34573476
153PRKACA0.32551308
154BLK0.32283547
155MAP2K20.32000569
156MOS0.31128594
157PDK20.30767852
158PINK10.30743265
159MAPK120.30491369
160INSR0.29025975
161FES0.28080431
162NTRK20.27474376
163LCK0.26899111
164CSK0.26748800
165STK110.26533855
166ABL20.26426515

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000624.53520959
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.49453564
3Steroid biosynthesis_Homo sapiens_hsa001004.48550898
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.58621430
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.25201125
6Leishmaniasis_Homo sapiens_hsa051402.70260705
7Ether lipid metabolism_Homo sapiens_hsa005652.63678686
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.57327095
9Other glycan degradation_Homo sapiens_hsa005112.54566160
10Osteoclast differentiation_Homo sapiens_hsa043802.53541216
11Allograft rejection_Homo sapiens_hsa053302.37185089
12Tuberculosis_Homo sapiens_hsa051522.32045957
13Histidine metabolism_Homo sapiens_hsa003402.28274018
14Graft-versus-host disease_Homo sapiens_hsa053322.27655578
15Sulfur metabolism_Homo sapiens_hsa009202.24503128
16Type I diabetes mellitus_Homo sapiens_hsa049402.19372480
17Nitrogen metabolism_Homo sapiens_hsa009102.10099471
18Asthma_Homo sapiens_hsa053102.07848742
19Butanoate metabolism_Homo sapiens_hsa006502.00273340
20Vitamin B6 metabolism_Homo sapiens_hsa007501.99284854
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.99147455
22Legionellosis_Homo sapiens_hsa051341.96868582
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.96002708
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.95465730
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.93357176
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87853857
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.68337832
28Oxidative phosphorylation_Homo sapiens_hsa001901.64951137
29Protein export_Homo sapiens_hsa030601.62681022
30Sphingolipid metabolism_Homo sapiens_hsa006001.61870264
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61245224
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60598278
33Pertussis_Homo sapiens_hsa051331.58912980
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55781904
35Antigen processing and presentation_Homo sapiens_hsa046121.53230080
36Linoleic acid metabolism_Homo sapiens_hsa005911.45548713
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40487621
38Toxoplasmosis_Homo sapiens_hsa051451.39897896
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.38681365
40Propanoate metabolism_Homo sapiens_hsa006401.37030716
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.36594081
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.36175375
43Fatty acid metabolism_Homo sapiens_hsa012121.35273771
44Hematopoietic cell lineage_Homo sapiens_hsa046401.30562167
45Arginine and proline metabolism_Homo sapiens_hsa003301.23549582
46Peroxisome_Homo sapiens_hsa041461.23292395
47Chemokine signaling pathway_Homo sapiens_hsa040621.19020768
48NF-kappa B signaling pathway_Homo sapiens_hsa040641.18306502
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17842564
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.17477227
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16788027
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16440707
53TNF signaling pathway_Homo sapiens_hsa046681.15443974
54Influenza A_Homo sapiens_hsa051641.15115403
55Measles_Homo sapiens_hsa051621.12197781
56Chemical carcinogenesis_Homo sapiens_hsa052041.07371199
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06380575
58Alzheimers disease_Homo sapiens_hsa050101.05805758
59Parkinsons disease_Homo sapiens_hsa050121.04623939
60Jak-STAT signaling pathway_Homo sapiens_hsa046301.04434157
61Salmonella infection_Homo sapiens_hsa051321.04258996
62African trypanosomiasis_Homo sapiens_hsa051431.02463038
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00947141
64Axon guidance_Homo sapiens_hsa043600.99582409
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99276225
66B cell receptor signaling pathway_Homo sapiens_hsa046620.98279628
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94958101
68GABAergic synapse_Homo sapiens_hsa047270.93505771
69Viral myocarditis_Homo sapiens_hsa054160.92622020
70Glutathione metabolism_Homo sapiens_hsa004800.92129324
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91793095
72Lysosome_Homo sapiens_hsa041420.90932745
73Collecting duct acid secretion_Homo sapiens_hsa049660.90751792
74Retinol metabolism_Homo sapiens_hsa008300.90004693
75Folate biosynthesis_Homo sapiens_hsa007900.88908226
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84437672
77Tyrosine metabolism_Homo sapiens_hsa003500.79880805
78Arachidonic acid metabolism_Homo sapiens_hsa005900.78402922
79Dorso-ventral axis formation_Homo sapiens_hsa043200.77545320
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76848710
81Vitamin digestion and absorption_Homo sapiens_hsa049770.76287088
82Rheumatoid arthritis_Homo sapiens_hsa053230.74730588
83Serotonergic synapse_Homo sapiens_hsa047260.74579011
84Complement and coagulation cascades_Homo sapiens_hsa046100.74465851
85beta-Alanine metabolism_Homo sapiens_hsa004100.74393246
86Hepatitis C_Homo sapiens_hsa051600.73377360
87Herpes simplex infection_Homo sapiens_hsa051680.72928321
88Fatty acid degradation_Homo sapiens_hsa000710.71087633
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69335056
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.68671076
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68577843
92Glutamatergic synapse_Homo sapiens_hsa047240.67700860
93Tryptophan metabolism_Homo sapiens_hsa003800.66655664
94Platelet activation_Homo sapiens_hsa046110.66620392
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66457163
96Staphylococcus aureus infection_Homo sapiens_hsa051500.66406144
97Vibrio cholerae infection_Homo sapiens_hsa051100.66025937
98Pyruvate metabolism_Homo sapiens_hsa006200.65649210
99Mineral absorption_Homo sapiens_hsa049780.63623946
100Morphine addiction_Homo sapiens_hsa050320.63371817
101Renal cell carcinoma_Homo sapiens_hsa052110.62962243
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62534754
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62462427
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.61916408
105T cell receptor signaling pathway_Homo sapiens_hsa046600.61724483
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61153977
107PPAR signaling pathway_Homo sapiens_hsa033200.60808018
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.58375049
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58305767
110ABC transporters_Homo sapiens_hsa020100.57955928
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57847725
112Fatty acid biosynthesis_Homo sapiens_hsa000610.57292325
113Prolactin signaling pathway_Homo sapiens_hsa049170.57258692
114Phagosome_Homo sapiens_hsa041450.56877937
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56623743
116Metabolic pathways_Homo sapiens_hsa011000.55088781
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52440766
118Autoimmune thyroid disease_Homo sapiens_hsa053200.51976163
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51594224
120Malaria_Homo sapiens_hsa051440.50515516
121Long-term depression_Homo sapiens_hsa047300.50196829
122Ovarian steroidogenesis_Homo sapiens_hsa049130.48870877
123Arginine biosynthesis_Homo sapiens_hsa002200.48649194
124Amoebiasis_Homo sapiens_hsa051460.48538716
125Hepatitis B_Homo sapiens_hsa051610.46016096
126Bile secretion_Homo sapiens_hsa049760.45828319
127Tight junction_Homo sapiens_hsa045300.43843944
128Shigellosis_Homo sapiens_hsa051310.43751049
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43156374
130Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41992434
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41936649
132Endocytosis_Homo sapiens_hsa041440.40179792
133Cardiac muscle contraction_Homo sapiens_hsa042600.39842339
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39687861
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.39314064
136Phenylalanine metabolism_Homo sapiens_hsa003600.38753362
137Cocaine addiction_Homo sapiens_hsa050300.38476263
138HIF-1 signaling pathway_Homo sapiens_hsa040660.37821491
139Glycerolipid metabolism_Homo sapiens_hsa005610.36722721
140Apoptosis_Homo sapiens_hsa042100.36641464
141Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35256150
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35141115
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.34638280
144Ras signaling pathway_Homo sapiens_hsa040140.33856051
145Circadian rhythm_Homo sapiens_hsa047100.33231422
146Huntingtons disease_Homo sapiens_hsa050160.32965474
147Prion diseases_Homo sapiens_hsa050200.32766870
148Type II diabetes mellitus_Homo sapiens_hsa049300.32748085
149Phototransduction_Homo sapiens_hsa047440.32555480
150FoxO signaling pathway_Homo sapiens_hsa040680.32305678
151Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32265717
152Salivary secretion_Homo sapiens_hsa049700.31915510
153Renin secretion_Homo sapiens_hsa049240.30687609
154Phospholipase D signaling pathway_Homo sapiens_hsa040720.28996562
155Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26944042
156Pancreatic secretion_Homo sapiens_hsa049720.25623147
157Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25547541
158Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25285507
159Regulation of autophagy_Homo sapiens_hsa041400.24064353
160Nicotine addiction_Homo sapiens_hsa050330.23859009
161Circadian entrainment_Homo sapiens_hsa047130.23566405
162Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22900716
163Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22396172
164Synaptic vesicle cycle_Homo sapiens_hsa047210.22092311
165Acute myeloid leukemia_Homo sapiens_hsa052210.21833864
166mTOR signaling pathway_Homo sapiens_hsa041500.21659216

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