RNF130

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growth factor withdrawal-induced apoptosis of myeloid precursor cells. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of interleukin-12 production (GO:0032695)5.08324705
2L-phenylalanine catabolic process (GO:0006559)4.87322950
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.87322950
4positive regulation of gamma-delta T cell activation (GO:0046645)4.70366409
5L-phenylalanine metabolic process (GO:0006558)4.35578966
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.35578966
7regulation of mast cell degranulation (GO:0043304)4.34084309
8negative regulation of erythrocyte differentiation (GO:0045647)4.25482929
9immunoglobulin mediated immune response (GO:0016064)4.21837841
10detection of molecule of bacterial origin (GO:0032490)4.07093266
11detection of other organism (GO:0098543)4.06452901
12cellular response to thyroid hormone stimulus (GO:0097067)4.01755234
13regulation of mast cell activation involved in immune response (GO:0033006)4.01199104
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.93237825
15negative regulation of cell killing (GO:0031342)3.93237825
16microglial cell activation (GO:0001774)3.90608752
17regulation of myeloid leukocyte mediated immunity (GO:0002886)3.84395011
18regulation of leukocyte degranulation (GO:0043300)3.81730964
19regulation of mast cell activation (GO:0033003)3.76604042
20neutrophil activation involved in immune response (GO:0002283)3.75319598
21detection of external biotic stimulus (GO:0098581)3.75284587
22detection of bacterium (GO:0016045)3.72283183
23positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.70578830
24macrophage activation (GO:0042116)3.69898880
25granulocyte activation (GO:0036230)3.66225296
26neutrophil activation (GO:0042119)3.64316311
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.61587756
28Golgi transport vesicle coating (GO:0048200)3.57209161
29COPI coating of Golgi vesicle (GO:0048205)3.57209161
30aromatic amino acid family catabolic process (GO:0009074)3.49127249
31response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.48883115
32response to host immune response (GO:0052572)3.48883115
33myeloid cell activation involved in immune response (GO:0002275)3.46290686
34alpha-linolenic acid metabolic process (GO:0036109)3.44162319
35response to muramyl dipeptide (GO:0032495)3.42253876
36detection of biotic stimulus (GO:0009595)3.41761589
37response to lipoprotein particle (GO:0055094)3.40405015
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.40174942
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.40174942
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.40174942
41modulation by symbiont of host immune response (GO:0052553)3.40174942
42positive regulation by symbiont of host defense response (GO:0052509)3.40174942
43modulation by symbiont of host defense response (GO:0052031)3.40174942
44cellular extravasation (GO:0045123)3.35586370
45lipopolysaccharide-mediated signaling pathway (GO:0031663)3.34509649
46antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.33762886
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.33762886
48positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.32804197
49regulation of regulated secretory pathway (GO:1903305)3.25811093
50peptidyl-glutamic acid carboxylation (GO:0017187)3.25528631
51protein carboxylation (GO:0018214)3.25528631
52regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.23458370
53amino sugar catabolic process (GO:0046348)3.23340383
54glycosphingolipid catabolic process (GO:0046479)3.21080424
55production of molecular mediator involved in inflammatory response (GO:0002532)3.20903150
56amyloid precursor protein catabolic process (GO:0042987)3.20872526
57regulation of gamma-delta T cell activation (GO:0046643)3.18087962
58defense response to protozoan (GO:0042832)3.16117859
59complement activation, alternative pathway (GO:0006957)3.11332631
60interferon-gamma-mediated signaling pathway (GO:0060333)3.10911087
61T-helper 1 type immune response (GO:0042088)3.09819164
62respiratory burst (GO:0045730)3.09200929
63positive regulation of antigen processing and presentation (GO:0002579)3.08800182
64leukocyte migration involved in inflammatory response (GO:0002523)3.08046273
65fatty acid elongation (GO:0030497)3.07465268
66regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.06103943
67regulation of interferon-beta biosynthetic process (GO:0045357)3.05754537
68positive regulation of cellular amide metabolic process (GO:0034250)3.05427688
69central nervous system myelination (GO:0022010)3.02249719
70axon ensheathment in central nervous system (GO:0032291)3.02249719
71response to protozoan (GO:0001562)3.01857734
72sequestering of metal ion (GO:0051238)3.01522064
73neutrophil mediated immunity (GO:0002446)3.01206517
74positive regulation of regulated secretory pathway (GO:1903307)3.01136208
75plasma lipoprotein particle clearance (GO:0034381)3.00718458
76triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.99913422
77oligosaccharide catabolic process (GO:0009313)2.97788435
78response to host (GO:0075136)2.97068122
79response to host defenses (GO:0052200)2.97068122
80response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.97068122
81antigen processing and presentation of endogenous antigen (GO:0019883)2.95815426
82fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.95760730
83B cell mediated immunity (GO:0019724)2.94191162
84regulation of antigen processing and presentation (GO:0002577)2.93418293
85regulation of B cell receptor signaling pathway (GO:0050855)2.93380755
86signal peptide processing (GO:0006465)2.92944985
87response to thyroid hormone (GO:0097066)2.92378672
88positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.91833182
89positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.89590555
90macrophage activation involved in immune response (GO:0002281)2.88259613
91germinal center formation (GO:0002467)2.86973257
92glycolipid catabolic process (GO:0019377)2.86823614
93negative regulation of interleukin-1 beta production (GO:0032691)2.83285811
94negative regulation of interleukin-17 production (GO:0032700)2.83260465
95bile acid biosynthetic process (GO:0006699)2.80439012
96negative regulation of lymphocyte mediated immunity (GO:0002707)2.80381626
97negative regulation of cytokine production involved in immune response (GO:0002719)2.78768078
98positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.78635268
99N-acetylneuraminate metabolic process (GO:0006054)2.74976745
100very long-chain fatty acid metabolic process (GO:0000038)2.74637576
101L-alpha-amino acid transmembrane transport (GO:1902475)2.71682764
102phagosome maturation (GO:0090382)2.71012688
103regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.70940959
104negative regulation of leukocyte mediated immunity (GO:0002704)2.70461656
105negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.70103488
106long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.69775740
107disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.69060904
108killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.69060904
109amyloid precursor protein metabolic process (GO:0042982)2.68929633
110regulation of T-helper 2 cell differentiation (GO:0045628)2.66863682
111neutrophil chemotaxis (GO:0030593)2.66270323
112mature B cell differentiation involved in immune response (GO:0002313)2.65253759
113positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.65057336
114positive regulation of monocyte chemotaxis (GO:0090026)2.64141837
115tyrosine metabolic process (GO:0006570)2.63381319
116regulation of hypersensitivity (GO:0002883)2.63178373
117positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.62750477
118regulation of interleukin-6 biosynthetic process (GO:0045408)2.62678546
119negative regulation of granulocyte differentiation (GO:0030853)2.62220932
120negative regulation of interleukin-6 production (GO:0032715)2.62043128
121myeloid leukocyte activation (GO:0002274)2.61846319
122sulfur amino acid catabolic process (GO:0000098)2.61708111
123glyoxylate metabolic process (GO:0046487)2.61054031
124regulation of cholesterol biosynthetic process (GO:0045540)2.60498460
125leukocyte aggregation (GO:0070486)2.60440609
126fatty-acyl-CoA biosynthetic process (GO:0046949)2.60430323
127positive regulation of macrophage cytokine production (GO:0060907)2.59901024
128bile acid metabolic process (GO:0008206)2.59776490
129neutrophil migration (GO:1990266)2.59219300
130myeloid leukocyte mediated immunity (GO:0002444)2.58583491
131positive regulation of leukocyte degranulation (GO:0043302)2.58087484
132cholesterol efflux (GO:0033344)2.57884136
133low-density lipoprotein particle clearance (GO:0034383)2.56191840
134high-density lipoprotein particle remodeling (GO:0034375)2.54525355
135opsonization (GO:0008228)2.54151959
136creatine metabolic process (GO:0006600)2.53673614
137endocrine pancreas development (GO:0031018)2.53552396
138reverse cholesterol transport (GO:0043691)2.51855951
139regulation of lipoprotein metabolic process (GO:0050746)2.51614987
140regulation of triglyceride catabolic process (GO:0010896)2.51360241
141positive regulation of B cell differentiation (GO:0045579)2.51234885
142phospholipid efflux (GO:0033700)2.50783830
143response to methylmercury (GO:0051597)2.49944317
144drug transmembrane transport (GO:0006855)2.49708045
145regulation of cholesterol metabolic process (GO:0090181)2.47875873
146regulation of protein activation cascade (GO:2000257)2.45672431
147cysteine metabolic process (GO:0006534)2.44440562
148cofactor catabolic process (GO:0051187)2.44222234
149aldehyde catabolic process (GO:0046185)2.43584148
150glycosylceramide metabolic process (GO:0006677)2.41871294
151response to peptidoglycan (GO:0032494)2.40482715
152COPII vesicle coating (GO:0048208)2.38936853
153peptide hormone processing (GO:0016486)2.38322726
154hydrogen peroxide biosynthetic process (GO:0050665)2.37913542
155regulation of complement activation (GO:0030449)2.36915948
156aromatic amino acid family metabolic process (GO:0009072)2.36453031
157macroautophagy (GO:0016236)2.36223341
158positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.35287185
159myelin maintenance (GO:0043217)2.34996486
160protein-lipid complex assembly (GO:0065005)2.34191492
161protein-lipid complex remodeling (GO:0034368)2.32695333
162macromolecular complex remodeling (GO:0034367)2.32695333
163plasma lipoprotein particle remodeling (GO:0034369)2.32695333
164intracellular pH reduction (GO:0051452)2.31969524
165adenosine receptor signaling pathway (GO:0001973)2.31876810
166mannose metabolic process (GO:0006013)2.30698007
167fatty-acyl-CoA metabolic process (GO:0035337)2.30622839
168positive regulation of cellular amine metabolic process (GO:0033240)2.30277193
169positive regulation of mast cell activation (GO:0033005)2.30177490
170ethanol oxidation (GO:0006069)2.29858181
171regulation of cholesterol esterification (GO:0010872)2.29266177
172heme transport (GO:0015886)2.28937272
173tryptophan metabolic process (GO:0006568)2.28522388
174positive regulation of steroid metabolic process (GO:0045940)2.28428122
175positive regulation of mast cell degranulation (GO:0043306)2.28288228
176positive regulation of mast cell activation involved in immune response (GO:0033008)2.28288228
177reactive oxygen species biosynthetic process (GO:1903409)2.28068612
178plasma lipoprotein particle assembly (GO:0034377)2.27411376

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.57518182
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.12967663
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.06346066
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.53650895
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.47008219
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.35683891
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.19449229
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.11286268
9GATA1_22025678_ChIP-Seq_K562_Human3.08510699
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.02674321
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.92447268
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.92299611
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.86675164
14SCL_19346495_ChIP-Seq_HPC-7_Human2.85639677
15* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.80822370
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.59737372
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.55995344
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.40194663
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.38916300
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.32181665
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.27776465
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.24437088
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.02646359
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.01512309
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.93794573
26* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90957814
27* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.78273200
28KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77920698
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75846145
30VDR_24763502_ChIP-Seq_THP-1_Human1.68828467
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.62627323
32* GATA1_19941826_ChIP-Seq_K562_Human1.62591863
33SPI1_23127762_ChIP-Seq_K562_Human1.60188381
34* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56999506
35VDR_21846776_ChIP-Seq_THP-1_Human1.55047980
36SPI1_23547873_ChIP-Seq_NB4_Human1.54365270
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.54148879
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.54138569
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53038151
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51662976
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50329245
42KDM2B_26808549_Chip-Seq_DND41_Human1.47351895
43RUNX_20019798_ChIP-Seq_JUKART_Human1.45429343
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42105181
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40230474
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.39941792
47GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39761922
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.39690873
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38501879
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.37544825
51* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37329276
52* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.36603500
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36576998
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32862028
55CLOCK_20551151_ChIP-Seq_293T_Human1.32530798
56* PU_27001747_Chip-Seq_BMDM_Mouse1.30658848
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29273172
58BCL6_27268052_Chip-Seq_Bcells_Human1.28578206
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26431563
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26239334
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25932530
62GATA3_27048872_Chip-Seq_THYMUS_Human1.23944212
63DROSHA_22980978_ChIP-Seq_HELA_Human1.23075127
64EZH2_22144423_ChIP-Seq_EOC_Human1.23055731
65* GATA1_19941827_ChIP-Seq_MEL_Mouse1.21461412
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20245660
67MYB_26560356_Chip-Seq_TH2_Human1.17685843
68FOXA2_19822575_ChIP-Seq_HepG2_Human1.17667436
69* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16575682
70FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16404786
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16207298
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16095764
73VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14422192
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13986239
75VDR_24787735_ChIP-Seq_THP-1_Human1.13370570
76* GATA2_19941826_ChIP-Seq_K562_Human1.13154263
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12919585
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12095232
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11273836
80GATA3_26560356_Chip-Seq_TH2_Human1.11254220
81MAF_26560356_Chip-Seq_TH2_Human1.10533520
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09731785
83PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08989079
84PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07835876
85* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06901524
86MAF_26560356_Chip-Seq_TH1_Human1.06277303
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06035360
88BCOR_27268052_Chip-Seq_Bcells_Human1.05486412
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03576744
90MYC_22102868_ChIP-Seq_BL_Human1.02959993
91DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02209638
92MYB_26560356_Chip-Seq_TH1_Human1.01895278
93STAT1_20625510_ChIP-Seq_HELA_Human1.01774620
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00266464
95SPI1_20517297_ChIP-Seq_HL60_Human0.98682612
96FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98660057
97FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98571643
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97994775
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97734342
100TCF7_22412390_ChIP-Seq_EML_Mouse0.96672717
101FOXO3_23340844_ChIP-Seq_DLD1_Human0.96319502
102* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95848901
103EGR1_19032775_ChIP-ChIP_M12_Human0.95232357
104KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94150496
105* FOXA1_25552417_ChIP-Seq_VCAP_Human0.94044121
106MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93575476
107SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93434918
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92861859
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91982334
110ELF1_20517297_ChIP-Seq_JURKAT_Human0.91098112
111PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90666452
112* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89702736
113* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89589221
114ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88099612
115SOX2_20726797_ChIP-Seq_SW620_Human0.87946648
116* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87939155
117UTX_26944678_Chip-Seq_JUKART_Human0.87515934
118TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87353458
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87271434
120ELK3_25401928_ChIP-Seq_HUVEC_Human0.87209984
121* KDM2B_26808549_Chip-Seq_K562_Human0.86973834
122* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86158599
123NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84647433
124FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84047044
125LXR_22292898_ChIP-Seq_THP-1_Human0.82429175
126KDM2B_26808549_Chip-Seq_JURKAT_Human0.80542339
127* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.79769159
128P68_20966046_ChIP-Seq_HELA_Human0.76730838
129CTCF_26484167_Chip-Seq_Bcells_Mouse0.76662500
130SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.75484472
131OCT4_19829295_ChIP-Seq_ESCs_Human0.74091269

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.83217027
2MP0002139_abnormal_hepatobiliary_system3.62515338
3MP0009840_abnormal_foam_cell3.48766249
4MP0003195_calcinosis3.46810113
5MP0005365_abnormal_bile_salt2.98204823
6MP0005360_urolithiasis2.87950850
7MP0003191_abnormal_cellular_cholesterol2.82233367
8MP0003303_peritoneal_inflammation2.56919273
9MP0009278_abnormal_bone_marrow2.55712606
10MP0005085_abnormal_gallbladder_physiolo2.54786191
11MP0003172_abnormal_lysosome_physiology2.47826955
12MP0001545_abnormal_hematopoietic_system2.43787467
13MP0005397_hematopoietic_system_phenotyp2.43787467
14MP0003183_abnormal_peptide_metabolism2.38606169
15MP0008875_abnormal_xenobiotic_pharmacok2.37796887
16MP0003300_gastrointestinal_ulcer2.37310958
17MP0000920_abnormal_myelination2.33803697
18MP0003436_decreased_susceptibility_to2.28995307
19MP0003690_abnormal_glial_cell2.24913884
20MP0001835_abnormal_antigen_presentation2.21679683
21MP0006082_CNS_inflammation2.19999490
22MP0002419_abnormal_innate_immunity2.11786904
23MP0003806_abnormal_nucleotide_metabolis2.05541209
24MP0003252_abnormal_bile_duct2.00706384
25MP0005464_abnormal_platelet_physiology1.92288866
26MP0003724_increased_susceptibility_to1.86736613
27MP0010329_abnormal_lipoprotein_level1.80779432
28MP0000604_amyloidosis1.80206761
29MP0004043_abnormal_pH_regulation1.66948062
30MP0005025_abnormal_response_to1.66607780
31MP0005000_abnormal_immune_tolerance1.65259614
32MP0002118_abnormal_lipid_homeostasis1.61711997
33MP0009785_altered_susceptibility_to1.61341371
34MP0005083_abnormal_biliary_tract1.59935922
35MP0002148_abnormal_hypersensitivity_rea1.57559740
36MP0002693_abnormal_pancreas_physiology1.53697365
37MP0003075_altered_response_to1.52494147
38MP0008469_abnormal_protein_level1.52310190
39MP0000609_abnormal_liver_physiology1.51672875
40MP0002877_abnormal_melanocyte_morpholog1.51093507
41MP0005387_immune_system_phenotype1.50939501
42MP0001790_abnormal_immune_system1.50939501
43MP0001666_abnormal_nutrient_absorption1.47459214
44MP0009643_abnormal_urine_homeostasis1.47057899
45MP0005332_abnormal_amino_acid1.46031688
46MP0002138_abnormal_hepatobiliary_system1.45607217
47MP0001533_abnormal_skeleton_physiology1.44162717
48MP0000685_abnormal_immune_system1.38250074
49MP0005584_abnormal_enzyme/coenzyme_acti1.36667478
50MP0000465_gastrointestinal_hemorrhage1.36368381
51MP0003656_abnormal_erythrocyte_physiolo1.35313118
52MP0003828_pulmonary_edema1.34734018
53MP0002723_abnormal_immune_serum1.34583767
54MP0008260_abnormal_autophagy1.29980981
55MP0001845_abnormal_inflammatory_respons1.29798426
56MP0002452_abnormal_antigen_presenting1.28325320
57MP0000013_abnormal_adipose_tissue1.21297843
58MP0002909_abnormal_adrenal_gland1.19402409
59MP0001800_abnormal_humoral_immune1.17149007
60MP0001944_abnormal_pancreas_morphology1.16157312
61MP0002398_abnormal_bone_marrow1.15643389
62MP0005310_abnormal_salivary_gland1.15030801
63MP0001851_eye_inflammation1.14467657
64MP0005167_abnormal_blood-brain_barrier1.13047664
65MP0005319_abnormal_enzyme/_coenzyme1.11803185
66MP0002420_abnormal_adaptive_immunity1.11445648
67MP0001819_abnormal_immune_cell1.11048305
68MP0002653_abnormal_ependyma_morphology1.10931168
69MP0005671_abnormal_response_to1.09517377
70MP0008004_abnormal_stomach_pH1.09106137
71MP0000689_abnormal_spleen_morphology1.07998741
72MP0002078_abnormal_glucose_homeostasis1.07491183
73MP0004019_abnormal_vitamin_homeostasis1.06565136
74MP0004947_skin_inflammation1.06033273
75MP0005220_abnormal_exocrine_pancreas1.05096069
76MP0003329_amyloid_beta_deposits1.01409282
77MP0003868_abnormal_feces_composition1.01230624
78MP0009764_decreased_sensitivity_to1.00618147
79MP0003186_abnormal_redox_activity1.00157093
80MP0002429_abnormal_blood_cell0.99650552
81MP0009763_increased_sensitivity_to0.99451472
82MP0005379_endocrine/exocrine_gland_phen0.99386382
83MP0009333_abnormal_splenocyte_physiolog0.96401143
84MP0000858_altered_metastatic_potential0.94369556
85MP0004883_abnormal_blood_vessel0.93525447
86MP0005636_abnormal_mineral_homeostasis0.92940285
87MP0000343_altered_response_to0.92811603
88MP0002722_abnormal_immune_system0.90989282
89MP0001765_abnormal_ion_homeostasis0.89790686
90MP0004130_abnormal_muscle_cell0.89630042
91MP0002132_abnormal_respiratory_system0.89563183
92MP0001756_abnormal_urination0.88607832
93MP0009642_abnormal_blood_homeostasis0.88600123
94MP0000598_abnormal_liver_morphology0.87224781
95MP0001663_abnormal_digestive_system0.86898860
96MP0003448_altered_tumor_morphology0.86831591
97MP0005408_hypopigmentation0.86383846
98MP0002998_abnormal_bone_remodeling0.85200694
99MP0002933_joint_inflammation0.83858036
100MP0002166_altered_tumor_susceptibility0.83714883
101MP0001853_heart_inflammation0.83684464
102MP0001764_abnormal_homeostasis0.83526617
103MP0003634_abnormal_glial_cell0.83443221
104MP0003633_abnormal_nervous_system0.82402256
105MP0008874_decreased_physiological_sensi0.81273814
106MP0004510_myositis0.80423180
107MP0010155_abnormal_intestine_physiology0.79492233
108MP0002405_respiratory_system_inflammati0.79284238
109MP0003866_abnormal_defecation0.78854493
110MP0000639_abnormal_adrenal_gland0.78686417
111MP0005166_decreased_susceptibility_to0.78611104
112MP0009765_abnormal_xenobiotic_induced0.78510148
113MP0005390_skeleton_phenotype0.78175651
114MP0000716_abnormal_immune_system0.78002932
115MP0005164_abnormal_response_to0.77275560
116MP0003787_abnormal_imprinting0.77062377
117MP0001501_abnormal_sleep_pattern0.76713407
118MP0005535_abnormal_body_temperature0.76658537
119MP0006054_spinal_hemorrhage0.75575020
120MP0000003_abnormal_adipose_tissue0.75074968
121MP0005334_abnormal_fat_pad0.74670426
122MP0002064_seizures0.74171914
123MP0002971_abnormal_brown_adipose0.73590017
124MP0001661_extended_life_span0.73101784
125MP0005451_abnormal_body_composition0.72831834
126MP0003631_nervous_system_phenotype0.70977276
127MP0000015_abnormal_ear_pigmentation0.70151681
128MP0003879_abnormal_hair_cell0.70115714
129MP0000569_abnormal_digit_pigmentation0.68221678
130MP0003632_abnormal_nervous_system0.67755145
131MP0002277_abnormal_respiratory_mucosa0.65393330
132MP0005075_abnormal_melanosome_morpholog0.61445023
133MP0004742_abnormal_vestibular_system0.58431216
134MP0000681_abnormal_thyroid_gland0.58387987
135MP0005165_increased_susceptibility_to0.57899307
136MP0000249_abnormal_blood_vessel0.55183573
137MP0005647_abnormal_sex_gland0.54170261
138MP0003795_abnormal_bone_structure0.53023400
139MP0005666_abnormal_adipose_tissue0.52556319

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.91266550
2Dysostosis multiplex (HP:0000943)4.39585460
3Myositis (HP:0100614)4.25640084
4Systemic lupus erythematosus (HP:0002725)4.25235930
5Stomatitis (HP:0010280)4.24791017
6Vacuolated lymphocytes (HP:0001922)4.20365004
7Orchitis (HP:0100796)3.98225126
8Recurrent gram-negative bacterial infections (HP:0005420)3.97545894
9Hypoglycemic coma (HP:0001325)3.86488658
10Complement deficiency (HP:0004431)3.82944620
11Mutism (HP:0002300)3.81858305
12Increased cerebral lipofuscin (HP:0011813)3.81460424
13Mediastinal lymphadenopathy (HP:0100721)3.77467615
14Mucopolysacchariduria (HP:0008155)3.74274201
15Urinary glycosaminoglycan excretion (HP:0003541)3.74274201
16Optic neuritis (HP:0100653)3.72328337
17Retrobulbar optic neuritis (HP:0100654)3.72328337
18Recurrent bacterial skin infections (HP:0005406)3.64766800
19Recurrent abscess formation (HP:0002722)3.59893679
20Hypoglycemic seizures (HP:0002173)3.58863626
21Increased neuronal autofluorescent lipopigment (HP:0002074)3.57609018
22Xanthomatosis (HP:0000991)3.56987531
23Obstructive lung disease (HP:0006536)3.56099408
24Chronic obstructive pulmonary disease (HP:0006510)3.56099408
25Neurofibrillary tangles (HP:0002185)3.55040599
26Intrahepatic cholestasis (HP:0001406)3.51119193
27Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.48872207
28Eczematoid dermatitis (HP:0000976)3.45870934
29Abnormality of polysaccharide metabolism (HP:0011012)3.40918882
30Abnormality of glycosaminoglycan metabolism (HP:0004371)3.40918882
31Abnormality of mucopolysaccharide metabolism (HP:0011020)3.40918882
32Hyperinsulinemic hypoglycemia (HP:0000825)3.38862568
33Axonal loss (HP:0003447)3.35584131
34Abnormality of macrophages (HP:0004311)3.30023422
35Glomerulonephritis (HP:0000099)3.27794195
36Elevated erythrocyte sedimentation rate (HP:0003565)3.24236530
37Deep venous thrombosis (HP:0002625)3.20882163
38Hyperlipoproteinemia (HP:0010980)3.18226086
39Progressive neurologic deterioration (HP:0002344)3.07615683
40Abnormality of the common coagulation pathway (HP:0010990)3.06651997
41Abnormality of liposaccharide metabolism (HP:0010968)3.06530281
42Abnormality of glycosphingolipid metabolism (HP:0004343)3.06530281
43Abnormality of glycolipid metabolism (HP:0010969)3.06530281
44Petechiae (HP:0000967)3.02873849
45Recurrent fungal infections (HP:0002841)3.00921479
46Joint hemorrhage (HP:0005261)2.99760230
47Prolonged partial thromboplastin time (HP:0003645)2.98934667
48Prolonged bleeding time (HP:0003010)2.89362084
49Abnormality of complement system (HP:0005339)2.87598421
50Symptomatic seizures (HP:0011145)2.86873133
51Ketosis (HP:0001946)2.78183678
52Retinal atrophy (HP:0001105)2.77654506
53Meningitis (HP:0001287)2.75442990
54Abnormality of monocarboxylic acid metabolism (HP:0010996)2.70075731
55Autoimmune thrombocytopenia (HP:0001973)2.68920846
56Ketoacidosis (HP:0001993)2.68634504
57Abnormality of the pancreatic islet cells (HP:0006476)2.60268352
58Abnormality of endocrine pancreas physiology (HP:0012093)2.60268352
59Pancreatic islet-cell hyperplasia (HP:0004510)2.60150398
60Increased serum ferritin (HP:0003281)2.59470124
61Abnormality of the intrinsic pathway (HP:0010989)2.58903118
62Recurrent skin infections (HP:0001581)2.58331339
63Spontaneous hematomas (HP:0007420)2.58302534
64Chronic mucocutaneous candidiasis (HP:0002728)2.56874626
65Recurrent cutaneous fungal infections (HP:0011370)2.56874626
66Neuronal loss in central nervous system (HP:0002529)2.56416798
67Diminished motivation (HP:0000745)2.54802759
68Inappropriate behavior (HP:0000719)2.52672058
69Hepatosplenomegaly (HP:0001433)2.51820896
70Agnosia (HP:0010524)2.48093741
71Cerebral inclusion bodies (HP:0100314)2.47500940
72Keratoconjunctivitis sicca (HP:0001097)2.46399880
73Encephalitis (HP:0002383)2.43334043
74Loss of speech (HP:0002371)2.43026468
75Peripheral demyelination (HP:0011096)2.41142183
76Urticaria (HP:0001025)2.40784545
77Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.40153403
78Abnormality of the periventricular white matter (HP:0002518)2.39302540
79Apathy (HP:0000741)2.38413162
80Cellulitis (HP:0100658)2.37700775
81Hemoptysis (HP:0002105)2.34999336
82Amyloidosis (HP:0011034)2.34590096
83Abnormality of iron homeostasis (HP:0011031)2.34398505
84Gingival bleeding (HP:0000225)2.32117786
85Conjugated hyperbilirubinemia (HP:0002908)2.32007684
86Abnormality of the vasculature of the conjunctiva (HP:0008054)2.31797125
87Late onset (HP:0003584)2.30021535
88Pulmonary infiltrates (HP:0002113)2.29884830
89Myocardial infarction (HP:0001658)2.29241810
90Keratoconjunctivitis (HP:0001096)2.28741990
91Large for gestational age (HP:0001520)2.26395206
92Thoracic kyphosis (HP:0002942)2.23324731
93Chronic otitis media (HP:0000389)2.21439797
94Fat malabsorption (HP:0002630)2.20556163
95Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.18936451
96Epidermoid cyst (HP:0200040)2.16875497
97Memory impairment (HP:0002354)2.16089470
98Generalized aminoaciduria (HP:0002909)2.15409651
99Increased CSF protein (HP:0002922)2.13609491
100Vertigo (HP:0002321)2.13508031
101Vasculitis (HP:0002633)2.11915906
102Skin nodule (HP:0200036)2.10835629
103Abnormality of fatty-acid metabolism (HP:0004359)2.08930383
104Upper motor neuron abnormality (HP:0002127)2.06824581
105Personality changes (HP:0000751)2.06744324
106Chest pain (HP:0100749)2.06515292
107Gastrointestinal infarctions (HP:0005244)2.06155848
108Dementia (HP:0000726)2.05668746
109Hypercholesterolemia (HP:0003124)2.04046266
110Supranuclear gaze palsy (HP:0000605)2.03429438
111Leukocytosis (HP:0001974)1.98421175
112Global brain atrophy (HP:0002283)1.96392453
113Purpura (HP:0000979)1.95711824
114Interstitial pulmonary disease (HP:0006530)1.95509124
115Recurrent viral infections (HP:0004429)1.94639378
116Episodic fever (HP:0001954)1.94614069
117Polyneuropathy (HP:0001271)1.93604315
118Arterial thrombosis (HP:0004420)1.92942904
119Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.92635483
120Abnormality of transition element cation homeostasis (HP:0011030)1.92402318
121Agitation (HP:0000713)1.92338280
122Cerebral hemorrhage (HP:0001342)1.90856283
123Nuclear cataract (HP:0100018)1.90565249
124Hypobetalipoproteinemia (HP:0003563)1.90336366
125Visual hallucinations (HP:0002367)1.88582566
126Abnormal delayed hypersensitivity skin test (HP:0002963)1.88243902
127Pulmonary embolism (HP:0002204)1.87728984
128Cardiomegaly (HP:0001640)1.87486775
129Polyphagia (HP:0002591)1.86861281
130Hyperglycemia (HP:0003074)1.86769442
131Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.85838401
132Increased IgE level (HP:0003212)1.85539975
133Elevated alkaline phosphatase (HP:0003155)1.82812879
134Papilledema (HP:0001085)1.81184109
135Abnormality of the pleura (HP:0002103)1.80922310
136Mitral stenosis (HP:0001718)1.80700458
137Increased IgM level (HP:0003496)1.80491912
138Protuberant abdomen (HP:0001538)1.79877675
139Abnormality of the heme biosynthetic pathway (HP:0010472)1.79516196
140Impaired platelet aggregation (HP:0003540)1.78969608
141Abnormal platelet function (HP:0011869)1.78969608
142Inflammation of the large intestine (HP:0002037)1.78427188
143Pathologic fracture (HP:0002756)1.78405300
144Hematochezia (HP:0002573)1.77760207
145Disinhibition (HP:0000734)1.77737613
146Gingivitis (HP:0000230)1.76843975
147Epistaxis (HP:0000421)1.76334663
148Steatorrhea (HP:0002570)1.76266735
149Abnormality of purine metabolism (HP:0004352)1.75918562
150Hyperammonemia (HP:0001987)1.75684828
151Menorrhagia (HP:0000132)1.75356031
152Abnormality of the lumbar spine (HP:0100712)1.74942289
153Hyperbilirubinemia (HP:0002904)1.72408722
154Colitis (HP:0002583)1.71064850
155Nephritis (HP:0000123)1.71055422
156Abnormal enzyme/coenzyme activity (HP:0012379)1.71027940
157Hypokalemic alkalosis (HP:0001949)1.70936424
158Irritability (HP:0000737)1.70834322

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.52133481
2EPHB13.51733238
3MAPK153.18776282
4ERN12.96171641
5MAP3K112.69948351
6BLK2.54754172
7INSRR2.50642407
8TGFBR22.18331878
9IRAK42.18277609
10STK392.11737910
11TNK22.08517339
12KIT2.00613902
13MAP4K11.96071199
14IRAK31.88421638
15PIK3CG1.85972457
16FLT31.82499662
17TYK21.80516664
18WNK41.80253611
19BTK1.77414280
20CSF1R1.76898333
21TRIB31.74355906
22TBK11.72313525
23TAOK11.70677764
24PRPF4B1.67074556
25WNK31.57263236
26OXSR11.54167277
27DAPK21.54046639
28HIPK21.52414761
29TAOK21.50787676
30NME21.47313429
31BCKDK1.45079095
32TEC1.44279315
33MAPKAPK51.42469960
34CSK1.37112276
35PTK61.34317992
36BMPR21.32572806
37SCYL21.32286790
38PIM21.31558749
39ITK1.31360564
40FGFR41.29579899
41MET1.24710865
42JAK21.22816608
43EPHA31.19125111
44FES1.17774029
45MAP3K21.16249205
46CAMKK11.16087075
47ZAP701.14787031
48MAP3K131.10714621
49JAK11.09102460
50TXK1.09036657
51CAMK1D1.08555650
52ACVR1B1.07993923
53GRK61.07319736
54MAP2K31.04618572
55MAP3K11.04534733
56SIK11.01954982
57SIK20.99750844
58TIE10.97021161
59PASK0.94524945
60IRAK10.94100424
61CAMKK20.91587633
62SYK0.90492547
63LRRK20.88190121
64NTRK10.87543018
65RIPK40.86816432
66MAP2K20.86520693
67MARK20.86342269
68ADRBK20.86011753
69UHMK10.84473684
70MAP2K40.84294296
71WNK10.83895255
72MAP3K140.82721154
73CAMK1G0.81827176
74TESK20.81804365
75HCK0.81677906
76CLK10.81318988
77MOS0.80993805
78LYN0.80824844
79CDK190.79456854
80MAP3K50.78591041
81PKN20.78558626
82IKBKE0.77970647
83PKN10.77664438
84JAK30.77146214
85FGFR20.76262559
86LCK0.75604477
87PDPK10.73471722
88DYRK30.72792714
89PRKD10.69849555
90IKBKB0.66811113
91MARK30.66136596
92RIPK10.65441687
93FGR0.64757881
94GRK70.64498556
95PRKCH0.63910550
96PBK0.62792936
97GSK3A0.61029222
98MAPK120.60491605
99MAP3K60.59283972
100RET0.59030876
101KDR0.59001572
102CDC42BPA0.58780568
103DYRK1B0.57443422
104DDR20.57189389
105PDK10.57084335
106CSNK1A1L0.56741631
107MAPK70.56703957
108RPS6KL10.56341265
109RPS6KC10.56341265
110IRAK20.55092154
111MATK0.54756272
112TRPM70.53712369
113EGFR0.52529499
114RPS6KA60.52419042
115MAPK40.51872372
116MAP2K60.50618596
117PAK60.50411221
118CSNK1G30.49642871
119KSR20.49072705
120PIM10.47966062
121STK100.47894325
122PRKAA20.46561321
123NEK90.46327863
124PRKCQ0.46182346
125ABL20.45016781
126PINK10.44732185
127ABL10.43901389
128STK110.43758591
129PAK40.42712406
130TYRO30.42003186
131MAP3K30.41690375
132CAMK40.41588513
133TESK10.40654370
134FRK0.39964722
135CDK60.39622332
136FYN0.39621982
137CSNK1G10.39609559
138PTK20.39138877
139RAF10.38871713
140MAP3K100.38819005
141NLK0.38665256
142CAMK10.38558242
143PRKCD0.38226945
144YES10.36796534

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.55932656
2Nitrogen metabolism_Homo sapiens_hsa009103.29448875
3Staphylococcus aureus infection_Homo sapiens_hsa051503.09956531
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.66914221
5Allograft rejection_Homo sapiens_hsa053302.54505677
6Lysosome_Homo sapiens_hsa041422.51323385
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.37640882
8Sulfur metabolism_Homo sapiens_hsa009202.36301812
9Graft-versus-host disease_Homo sapiens_hsa053322.28223599
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.27658696
11Complement and coagulation cascades_Homo sapiens_hsa046102.23569043
12Fatty acid elongation_Homo sapiens_hsa000622.13697556
13Autoimmune thyroid disease_Homo sapiens_hsa053202.10134283
14Other glycan degradation_Homo sapiens_hsa005112.08655582
15Histidine metabolism_Homo sapiens_hsa003402.08392556
16Protein export_Homo sapiens_hsa030602.00729917
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.94865188
18Caffeine metabolism_Homo sapiens_hsa002321.84206384
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.79958145
20Steroid biosynthesis_Homo sapiens_hsa001001.79226020
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.75184526
22Tryptophan metabolism_Homo sapiens_hsa003801.64697231
23Fatty acid degradation_Homo sapiens_hsa000711.62746984
24Peroxisome_Homo sapiens_hsa041461.61312883
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.58673985
26ABC transporters_Homo sapiens_hsa020101.58095586
27Folate biosynthesis_Homo sapiens_hsa007901.56689606
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37350385
29Butanoate metabolism_Homo sapiens_hsa006501.37238325
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34568045
31Fatty acid metabolism_Homo sapiens_hsa012121.29176560
32Arginine biosynthesis_Homo sapiens_hsa002201.27832418
33Selenocompound metabolism_Homo sapiens_hsa004501.27292511
34Leishmaniasis_Homo sapiens_hsa051401.26344903
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26078056
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24760498
37Collecting duct acid secretion_Homo sapiens_hsa049661.23780997
38PPAR signaling pathway_Homo sapiens_hsa033201.22199501
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.21614303
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20067929
41Pertussis_Homo sapiens_hsa051331.20065530
42TNF signaling pathway_Homo sapiens_hsa046681.19603407
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17793122
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15521366
45African trypanosomiasis_Homo sapiens_hsa051431.14517249
46Viral myocarditis_Homo sapiens_hsa054161.13548725
47Influenza A_Homo sapiens_hsa051641.13087366
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09804161
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.08692633
50Propanoate metabolism_Homo sapiens_hsa006401.08200903
51Acute myeloid leukemia_Homo sapiens_hsa052211.07751308
52beta-Alanine metabolism_Homo sapiens_hsa004101.05972734
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05524905
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05077926
55Osteoclast differentiation_Homo sapiens_hsa043801.04922122
56Starch and sucrose metabolism_Homo sapiens_hsa005001.02610490
57Prion diseases_Homo sapiens_hsa050201.00078104
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98683873
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94667803
60B cell receptor signaling pathway_Homo sapiens_hsa046620.89659208
61Herpes simplex infection_Homo sapiens_hsa051680.88713154
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.86671716
63Phagosome_Homo sapiens_hsa041450.86128005
64Chemical carcinogenesis_Homo sapiens_hsa052040.84553358
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83360978
66Synaptic vesicle cycle_Homo sapiens_hsa047210.82410094
67Primary immunodeficiency_Homo sapiens_hsa053400.82041155
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.81141491
69Sphingolipid metabolism_Homo sapiens_hsa006000.80167636
70Ether lipid metabolism_Homo sapiens_hsa005650.79934393
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.79605708
72Bile secretion_Homo sapiens_hsa049760.79346134
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78211446
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78063099
75Tuberculosis_Homo sapiens_hsa051520.77929753
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77444744
77Fat digestion and absorption_Homo sapiens_hsa049750.76255853
78Measles_Homo sapiens_hsa051620.75920515
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74723795
80Retinol metabolism_Homo sapiens_hsa008300.72947429
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72207554
82Shigellosis_Homo sapiens_hsa051310.71721116
83Legionellosis_Homo sapiens_hsa051340.69328093
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66092079
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64187909
86T cell receptor signaling pathway_Homo sapiens_hsa046600.63362671
87Malaria_Homo sapiens_hsa051440.62811899
88Arginine and proline metabolism_Homo sapiens_hsa003300.62129639
89Amoebiasis_Homo sapiens_hsa051460.61775424
90Hepatitis C_Homo sapiens_hsa051600.61525013
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60701529
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60683359
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60261579
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60189185
95VEGF signaling pathway_Homo sapiens_hsa043700.59357197
96Hepatitis B_Homo sapiens_hsa051610.57788037
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.57681003
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57136252
99Antigen processing and presentation_Homo sapiens_hsa046120.56968926
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54683563
101Tyrosine metabolism_Homo sapiens_hsa003500.54623518
102N-Glycan biosynthesis_Homo sapiens_hsa005100.54619459
103Insulin resistance_Homo sapiens_hsa049310.54612171
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53535845
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.50865336
106Chemokine signaling pathway_Homo sapiens_hsa040620.50711718
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50584414
108Phenylalanine metabolism_Homo sapiens_hsa003600.50430782
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49167437
110Notch signaling pathway_Homo sapiens_hsa043300.49004658
111Type II diabetes mellitus_Homo sapiens_hsa049300.48882610
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.47945701
113Apoptosis_Homo sapiens_hsa042100.47475569
114Prolactin signaling pathway_Homo sapiens_hsa049170.47405599
115Linoleic acid metabolism_Homo sapiens_hsa005910.47035693
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46746604
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.46687276
118Vitamin digestion and absorption_Homo sapiens_hsa049770.45613777
119Rheumatoid arthritis_Homo sapiens_hsa053230.44752845
120Arachidonic acid metabolism_Homo sapiens_hsa005900.44400818
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.42683472
122Platelet activation_Homo sapiens_hsa046110.40396942
123Regulation of autophagy_Homo sapiens_hsa041400.39837334
124Asthma_Homo sapiens_hsa053100.39408151
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38811024
126GnRH signaling pathway_Homo sapiens_hsa049120.38567337
127Type I diabetes mellitus_Homo sapiens_hsa049400.38006065
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37511072
129Pentose phosphate pathway_Homo sapiens_hsa000300.36341575
130Hematopoietic cell lineage_Homo sapiens_hsa046400.36130509
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36064666
132Toxoplasmosis_Homo sapiens_hsa051450.35948600
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.35646337
134Glutathione metabolism_Homo sapiens_hsa004800.33521378
135Salmonella infection_Homo sapiens_hsa051320.32818007
136Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32743872
137Glycerolipid metabolism_Homo sapiens_hsa005610.32381090
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.32031495
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31969249
140Endocytosis_Homo sapiens_hsa041440.30864022
141Dorso-ventral axis formation_Homo sapiens_hsa043200.30429558
142Vibrio cholerae infection_Homo sapiens_hsa051100.29805104
143Bladder cancer_Homo sapiens_hsa052190.28698517
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.28630655
145Non-small cell lung cancer_Homo sapiens_hsa052230.28616544
146MAPK signaling pathway_Homo sapiens_hsa040100.28304904
147Renin secretion_Homo sapiens_hsa049240.28200450
148Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.25152687
149Pancreatic cancer_Homo sapiens_hsa052120.24695041
150Oxytocin signaling pathway_Homo sapiens_hsa049210.23696703
151Epstein-Barr virus infection_Homo sapiens_hsa051690.22690758
152Morphine addiction_Homo sapiens_hsa050320.22370849
153Long-term potentiation_Homo sapiens_hsa047200.21835685
154Rap1 signaling pathway_Homo sapiens_hsa040150.17580737

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