RNF133

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene has no intron. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.86336931
2spermatid development (GO:0007286)9.82383318
3axonemal dynein complex assembly (GO:0070286)9.80920715
4motile cilium assembly (GO:0044458)9.29710917
5cilium or flagellum-dependent cell motility (GO:0001539)9.19773406
6response to pheromone (GO:0019236)9.13171211
7regulation of cilium movement (GO:0003352)8.56106465
8cilium movement (GO:0003341)8.24107293
9single fertilization (GO:0007338)7.59778627
10sperm capacitation (GO:0048240)7.54578999
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.48495178
12synaptonemal complex organization (GO:0070193)7.00433760
13rRNA methylation (GO:0031167)6.96941485
14protein targeting to Golgi (GO:0000042)6.96026377
15male meiosis (GO:0007140)6.95859843
16negative regulation of inclusion body assembly (GO:0090084)6.95836279
17synaptonemal complex assembly (GO:0007130)6.90407530
18establishment of protein localization to Golgi (GO:0072600)6.75985360
19spermatogenesis (GO:0007283)6.61915881
20male gamete generation (GO:0048232)6.59481958
21piRNA metabolic process (GO:0034587)6.59162256
22retrograde transport, vesicle recycling within Golgi (GO:0000301)6.49031063
23organic cation transport (GO:0015695)6.45730499
24microtubule depolymerization (GO:0007019)6.43639474
25fertilization (GO:0009566)6.35451115
26phosphatidylethanolamine biosynthetic process (GO:0006646)6.14296808
27gamete generation (GO:0007276)6.06765336
28regulation of inclusion body assembly (GO:0090083)5.87461147
29spermatid nucleus differentiation (GO:0007289)5.87285904
30rRNA modification (GO:0000154)5.86486540
31phosphatidylethanolamine metabolic process (GO:0046337)5.73504040
32calcium ion-dependent exocytosis (GO:0017156)5.65374631
33centriole replication (GO:0007099)5.58609804
34cellular ketone body metabolic process (GO:0046950)5.55287064
35germ cell development (GO:0007281)5.42640138
36cellular process involved in reproduction in multicellular organism (GO:0022412)5.37907315
37ventricular system development (GO:0021591)5.23143831
38positive regulation of Rab GTPase activity (GO:0032851)5.18413018
39regulation of Rab GTPase activity (GO:0032313)5.18413018
40cell recognition (GO:0008037)5.10186316
41glycerol ether metabolic process (GO:0006662)5.08391180
42regulation of microtubule-based movement (GO:0060632)5.03574445
43protein localization to Golgi apparatus (GO:0034067)4.98196626
44chromosome condensation (GO:0030261)4.95552773
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.92269583
46sexual reproduction (GO:0019953)4.90736054
47ketone body metabolic process (GO:1902224)4.89668529
48multicellular organismal reproductive process (GO:0048609)4.78441383
49microtubule severing (GO:0051013)4.77486220
50ether metabolic process (GO:0018904)4.69983551
51chromosome organization involved in meiosis (GO:0070192)4.69791833
52regulation of centriole replication (GO:0046599)4.68409082
53DNA packaging (GO:0006323)4.66486633
54single strand break repair (GO:0000012)4.60836568
55male meiosis I (GO:0007141)4.55167546
56regulation of transcription involved in cell fate commitment (GO:0060850)4.53892802
57seminiferous tubule development (GO:0072520)4.37684229
58DNA methylation involved in gamete generation (GO:0043046)4.24206415
59left/right pattern formation (GO:0060972)4.14419825
60meiotic nuclear division (GO:0007126)4.12858855
61coenzyme catabolic process (GO:0009109)3.99478244
62chaperone-mediated protein complex assembly (GO:0051131)3.95640632
63glomerular visceral epithelial cell development (GO:0072015)3.85421821
64multicellular organismal development (GO:0007275)3.83011569
65negative regulation of Rho protein signal transduction (GO:0035024)3.80139207
66musculoskeletal movement (GO:0050881)3.79393785
67multicellular organismal movement (GO:0050879)3.79393785
68protein K11-linked deubiquitination (GO:0035871)3.77527237
69glomerular epithelial cell development (GO:0072310)3.68133815
70monoubiquitinated protein deubiquitination (GO:0035520)3.63738112
71genitalia morphogenesis (GO:0035112)3.61915602
72meiosis I (GO:0007127)3.60832468
73protein polyglutamylation (GO:0018095)3.52270575
74membrane protein intracellular domain proteolysis (GO:0031293)3.44679429
75sequestering of actin monomers (GO:0042989)3.41902258
76cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.35233978
77microtubule polymerization or depolymerization (GO:0031109)3.32756162
78protein refolding (GO:0042026)3.30810543
79glycolytic process (GO:0006096)3.24982753
80protein depolymerization (GO:0051261)3.24557822
81histone H3-K9 demethylation (GO:0033169)3.24495254
82peptidyl-threonine dephosphorylation (GO:0035970)3.23637828
83protein-DNA complex disassembly (GO:0032986)3.19987710
84nucleosome disassembly (GO:0006337)3.19987710
85microtubule nucleation (GO:0007020)3.18615812
86cerebral cortex neuron differentiation (GO:0021895)3.17873337
87response to acidic pH (GO:0010447)3.16919226
88meiotic cell cycle (GO:0051321)3.16725160
89cellular response to pH (GO:0071467)3.15658845
90nucleus organization (GO:0006997)3.15141888
91regulation of spindle checkpoint (GO:0090231)3.14237370
92regulation of interleukin-13 production (GO:0032656)3.10368269
93negative regulation of gene expression, epigenetic (GO:0045814)3.10215968
94cell differentiation involved in metanephros development (GO:0072202)3.04191679
95amino-acid betaine transport (GO:0015838)3.02341712
96carnitine transport (GO:0015879)3.02341712
97protein localization to cilium (GO:0061512)3.01867732
98polyol catabolic process (GO:0046174)3.00894741
99mesenchymal cell differentiation involved in kidney development (GO:0072161)3.00081311
100mesenchymal cell differentiation involved in renal system development (GO:2001012)3.00081311
101nucleoside diphosphate phosphorylation (GO:0006165)2.97356582
102Golgi to endosome transport (GO:0006895)2.96738195
103positive regulation of macrophage activation (GO:0043032)2.91981328
104regulation of T-helper 2 cell differentiation (GO:0045628)2.91037730
105homeostasis of number of cells within a tissue (GO:0048873)2.90025585
106DNA conformation change (GO:0071103)2.89685312
107alditol metabolic process (GO:0019400)2.88291318
108mitotic sister chromatid cohesion (GO:0007064)2.86855060
109cranial nerve morphogenesis (GO:0021602)2.86452133
110cilium organization (GO:0044782)2.85105636
111carnitine transmembrane transport (GO:1902603)2.84754375
112interferon-gamma secretion (GO:0072643)2.78143138
113microtubule-based movement (GO:0007018)2.75223435
114GTP biosynthetic process (GO:0006183)2.75222573
115mitotic G1 DNA damage checkpoint (GO:0031571)2.75059709
116cilium assembly (GO:0042384)2.74394885
117polyamine biosynthetic process (GO:0006596)2.74295870
118regulation of somitogenesis (GO:0014807)2.73870275
119chromatin silencing (GO:0006342)2.71468368
120synapsis (GO:0007129)2.70545562
121NAD biosynthetic process (GO:0009435)2.70456248
122meiotic cell cycle process (GO:1903046)2.70253929
123lactate metabolic process (GO:0006089)2.70051609
124cellular component assembly involved in morphogenesis (GO:0010927)2.69546470
125receptor recycling (GO:0001881)2.66844406
126regulation of phosphoprotein phosphatase activity (GO:0043666)2.66732164
127RNA localization (GO:0006403)2.65093798
128intraciliary transport (GO:0042073)2.63263114
129cilium morphogenesis (GO:0060271)2.59431818
130centriole assembly (GO:0098534)2.57475358
131regulation of cilium assembly (GO:1902017)2.56708473
132RNA destabilization (GO:0050779)2.55587699
133axoneme assembly (GO:0035082)2.50992179
134negative regulation of organelle assembly (GO:1902116)2.50081487
135UTP biosynthetic process (GO:0006228)2.45140408
136peptidyl-glutamic acid modification (GO:0018200)2.44850680
137glycerol metabolic process (GO:0006071)2.41684015
138sperm motility (GO:0030317)14.2811910
139cell wall macromolecule metabolic process (GO:0044036)13.9790447
140cell wall macromolecule catabolic process (GO:0016998)13.9790447
141fusion of sperm to egg plasma membrane (GO:0007342)13.6670008
142acrosome reaction (GO:0007340)12.0934981
143sperm-egg recognition (GO:0035036)11.7359946
144acrosome assembly (GO:0001675)11.7047003
145multicellular organism reproduction (GO:0032504)11.2793718
146binding of sperm to zona pellucida (GO:0007339)10.6358200
147cell-cell recognition (GO:0009988)10.5155583
148plasma membrane fusion (GO:0045026)10.4306256
149epithelial cilium movement (GO:0003351)10.1927452

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.22209555
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.30240674
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.28027573
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.15921069
5EZH2_22144423_ChIP-Seq_EOC_Human3.88494599
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.69322196
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.43759899
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.02586572
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.83366506
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.61998654
11CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.22949556
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.21937190
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.17370193
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09534779
15GATA1_26923725_Chip-Seq_HPCs_Mouse2.05061056
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.04621557
17ELF1_20517297_ChIP-Seq_JURKAT_Human1.97775984
18VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.97569747
19ZNF274_21170338_ChIP-Seq_K562_Hela1.94423738
20ERA_21632823_ChIP-Seq_H3396_Human1.90969638
21KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.90933836
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89209939
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87307426
24RAC3_21632823_ChIP-Seq_H3396_Human1.84845269
25DROSHA_22980978_ChIP-Seq_HELA_Human1.82983163
26TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.79080712
27STAT1_17558387_ChIP-Seq_HELA_Human1.75314717
28NANOG_20526341_ChIP-Seq_ESCs_Human1.75142522
29RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.73690903
30EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.71468031
31* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.71245227
32ELK4_26923725_Chip-Seq_MESODERM_Mouse1.68852563
33* FUS_26573619_Chip-Seq_HEK293_Human1.68265466
34CTCF_27219007_Chip-Seq_Bcells_Human1.67702182
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66480080
36FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65988664
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.63692529
38* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.63246373
39ER_23166858_ChIP-Seq_MCF-7_Human1.62062582
40MYC_19829295_ChIP-Seq_ESCs_Human1.61747874
41ARNT_22903824_ChIP-Seq_MCF-7_Human1.61590901
42GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.61272430
43KDM2B_26808549_Chip-Seq_REH_Human1.59962767
44* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.58890879
45KAP1_22055183_ChIP-Seq_ESCs_Mouse1.58569208
46TDRD3_21172665_ChIP-Seq_MCF-7_Human1.57556927
47SMAD4_21741376_ChIP-Seq_EPCs_Human1.57386239
48TAF2_19829295_ChIP-Seq_ESCs_Human1.57175170
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55802856
50WDR5_24793694_ChIP-Seq_LNCAP_Human1.54821494
51* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.54154183
52TAL1_26923725_Chip-Seq_HPCs_Mouse1.53814506
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.53204402
54GATA3_21867929_ChIP-Seq_CD8_Mouse1.52751763
55BCL6_27268052_Chip-Seq_Bcells_Human1.51399940
56AR_25329375_ChIP-Seq_VCAP_Human1.48332828
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48161246
58CBP_20019798_ChIP-Seq_JUKART_Human1.48161246
59SMC4_20622854_ChIP-Seq_HELA_Human1.47564898
60PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.47487740
61E2F1_20622854_ChIP-Seq_HELA_Human1.47423843
62CBX2_22325352_ChIP-Seq_293T-Rex_Human1.43211013
63HNFA_21074721_ChIP-Seq_CACO-2_Human1.43200803
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.42317471
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.41939542
66RBPJ_21746931_ChIP-Seq_IB4_Human1.40264898
67TP63_22573176_ChIP-Seq_HFKS_Human1.40114881
68OCT4_20526341_ChIP-Seq_ESCs_Human1.39971306
69CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.38986974
70BCOR_27268052_Chip-Seq_Bcells_Human1.38945632
71CTCF_20526341_ChIP-Seq_ESCs_Human1.38690139
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37529760
73ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37419221
74PHF8_20622854_ChIP-Seq_HELA_Human1.36933532
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36424835
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.36368737
77ETV1_20927104_ChIP-Seq_GIST48_Human1.36103900
78SMAD3_21741376_ChIP-Seq_ESCs_Human1.35651024
79LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.34194663
80P68_20966046_ChIP-Seq_HELA_Human1.34064930
81PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.33938335
82GATA3_21867929_ChIP-Seq_TH1_Mouse1.33192374
83REST_21632747_ChIP-Seq_MESCs_Mouse1.31957575
84FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.31855578
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31144184
86P53_21459846_ChIP-Seq_SAOS-2_Human1.31137747
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.29904697
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28502935
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.27588585
90* P300_19829295_ChIP-Seq_ESCs_Human1.27229553
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27116074
92SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26420159
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26206310
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26039895
95TBL1_22424771_ChIP-Seq_293T_Human1.25946778
96SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24771513
97GATA3_21878914_ChIP-Seq_MCF-7_Human1.24195903
98SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23174727
99P300_27268052_Chip-Seq_Bcells_Human1.22364425
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21813003
101* VDR_22108803_ChIP-Seq_LS180_Human1.21588105
102SMAD4_21741376_ChIP-Seq_HESCs_Human1.21069825
103* TP53_18474530_ChIP-ChIP_U2OS_Human1.20448112
104CEBPB_22108803_ChIP-Seq_LS180_Human1.20006852
105GF1_26923725_Chip-Seq_HPCs_Mouse1.19924971
106LXR_22292898_ChIP-Seq_THP-1_Human1.19485180
107PHF8_20622853_ChIP-Seq_HELA_Human1.18736089
108ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18710326
109CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18452801
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18441265
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17893056
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17893056
113NANOG_18555785_Chip-Seq_ESCs_Mouse1.17892757
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.16885996
115TAF15_26573619_Chip-Seq_HEK293_Human1.15591986
116P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.15447064
117RAD21_21589869_ChIP-Seq_MESCs_Mouse1.14731273
118* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14248333
119GATA6_21074721_ChIP-Seq_CACO-2_Human1.14169514
120RUNX2_22187159_ChIP-Seq_PCA_Human1.14164900
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14066346
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13702354
123RUNX_20019798_ChIP-Seq_JUKART_Human1.13426859
124SPI1_26923725_Chip-Seq_HPCs_Mouse1.12018052
125CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11734107
126PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11732818
127RUNX1_26923725_Chip-Seq_HPCs_Mouse1.11255138
128SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11248953
129PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10310464
130OCT4_18555785_Chip-Seq_ESCs_Mouse1.09348192
131TCF4_18268006_ChIP-ChIP_LS174T_Human1.09123962
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08936832
133STAT3_23295773_ChIP-Seq_U87_Human1.08795811
134SMAD4_21799915_ChIP-Seq_A2780_Human1.08739746
135PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.08007555
136NFYA_21822215_ChIP-Seq_K562_Human1.07804748
137P53_22387025_ChIP-Seq_ESCs_Mouse1.07417577
138SA1_27219007_Chip-Seq_Bcells_Human1.06797553
139CMYC_18555785_Chip-Seq_ESCs_Mouse1.06748775
140SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06500775
141EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06412683
142SMRT_27268052_Chip-Seq_Bcells_Human1.06008502
143ESET_19884257_ChIP-Seq_ESCs_Mouse1.05403935
144ERG_20517297_ChIP-Seq_VCAP_Human1.05366772
145EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04985773
146NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04829793
147HOXB7_26014856_ChIP-Seq_BT474_Human1.04388646
148MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04027535
149EZH2_27294783_Chip-Seq_ESCs_Mouse1.03040178
150GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02386339
151OCT1_27270436_Chip-Seq_PROSTATE_Human1.00928633
152P300_18555785_Chip-Seq_ESCs_Mouse1.00628068
153GATA1_19941827_ChIP-Seq_MEL86_Mouse1.00526427
154KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.99703449
155PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99278916
156KLF4_18555785_Chip-Seq_ESCs_Mouse0.97817143
157OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97328450
158RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97267484
159RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97075587
160SOX9_26525672_Chip-Seq_HEART_Mouse0.96817478
161RNF2_27304074_Chip-Seq_NSC_Mouse0.96807489
162RARA_24833708_ChIP-Seq_LIVER_Mouse0.96422902
163SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96392858
164MYC_27129775_Chip-Seq_CORNEA_Mouse0.96385251
165EZH2_27294783_Chip-Seq_NPCs_Mouse0.94984893
166ESRRB_18555785_Chip-Seq_ESCs_Mouse0.94823578
167YY1_22570637_ChIP-Seq_MALME-3M_Human0.94527582
168NFYB_21822215_ChIP-Seq_K562_Human0.93074096
169LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92869299
170JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.92283473
171SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91790661
172GF1B_26923725_Chip-Seq_HPCs_Mouse0.91292822
173EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91122758
174FLI1_21867929_ChIP-Seq_CD8_Mouse0.89958410

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.14871750
2MP0001929_abnormal_gametogenesis5.57893290
3MP0008877_abnormal_DNA_methylation3.95230057
4MP0001348_abnormal_lacrimal_gland3.41922326
5MP0002210_abnormal_sex_determination3.38490603
6MP0002161_abnormal_fertility/fecundity3.36199299
7MP0001145_abnormal_male_reproductive2.87776290
8MP0005670_abnormal_white_adipose2.85868731
9MP0000653_abnormal_sex_gland2.50286347
10MP0000678_abnormal_parathyroid_gland2.42979815
11MP0002653_abnormal_ependyma_morphology2.36665374
12MP0003718_maternal_effect2.12919269
13MP0005410_abnormal_fertilization16.5925013
14MP0005379_endocrine/exocrine_gland_phen1.69619069
15MP0001485_abnormal_pinna_reflex1.66056565
16MP0001486_abnormal_startle_reflex1.65121391
17MP0002249_abnormal_larynx_morphology1.64330650
18MP0005623_abnormal_meninges_morphology1.52209646
19MP0002160_abnormal_reproductive_system1.46059258
20MP0005310_abnormal_salivary_gland1.44501082
21MP0004510_myositis1.43370604
22MP0004233_abnormal_muscle_weight1.41513539
23MP0003646_muscle_fatigue1.40074602
24MP0005248_abnormal_Harderian_gland1.36268612
25MP0009053_abnormal_anal_canal1.35426135
26MP0002282_abnormal_trachea_morphology1.29526320
27MP0001765_abnormal_ion_homeostasis1.22339435
28MP0004859_abnormal_synaptic_plasticity1.19597379
29MP0002127_abnormal_cardiovascular_syste1.19055990
30MP0001963_abnormal_hearing_physiology1.18137689
31MP0002138_abnormal_hepatobiliary_system1.10758827
32MP0005451_abnormal_body_composition1.10128806
33MP0002735_abnormal_chemical_nociception1.04826110
34MP0000026_abnormal_inner_ear1.03412473
35MP0002822_catalepsy0.98116031
36MP0001984_abnormal_olfaction0.97912672
37MP0005395_other_phenotype0.97849687
38MP0008058_abnormal_DNA_repair0.95915830
39MP0005647_abnormal_sex_gland0.92225794
40MP0009046_muscle_twitch0.91160208
41MP0000955_abnormal_spinal_cord0.88065730
42MP0000681_abnormal_thyroid_gland0.81242799
43MP0000049_abnormal_middle_ear0.78918448
44MP0002234_abnormal_pharynx_morphology0.77338435
45MP0002733_abnormal_thermal_nociception0.75290194
46MP0002067_abnormal_sensory_capabilities0.74718434
47MP0004085_abnormal_heartbeat0.73808118
48MP0005389_reproductive_system_phenotype0.73771013
49MP0001879_abnormal_lymphatic_vessel0.71158590
50MP0003115_abnormal_respiratory_system0.70658474
51MP0008995_early_reproductive_senescence0.70628450
52MP0005083_abnormal_biliary_tract0.70095059
53MP0009697_abnormal_copulation0.69772965
54MP0005636_abnormal_mineral_homeostasis0.68554324
55MP0005167_abnormal_blood-brain_barrier0.68499354
56MP0002557_abnormal_social/conspecific_i0.65566381
57MP0003878_abnormal_ear_physiology0.64307982
58MP0005377_hearing/vestibular/ear_phenot0.64307982
59MP0000516_abnormal_urinary_system0.62072757
60MP0005367_renal/urinary_system_phenotyp0.62072757
61MP0004484_altered_response_of0.61920169
62MP0003011_delayed_dark_adaptation0.57405071
63MP0001666_abnormal_nutrient_absorption0.57337396
64MP0002572_abnormal_emotion/affect_behav0.57300052
65MP0002734_abnormal_mechanical_nocicepti0.55559094
66MP0005666_abnormal_adipose_tissue0.55065713
67MP0001324_abnormal_eye_pigmentation0.53543594
68MP0004036_abnormal_muscle_relaxation0.53443473
69MP0001905_abnormal_dopamine_level0.52910073
70MP0003077_abnormal_cell_cycle0.52444394
71MP0001970_abnormal_pain_threshold0.51082077
72MP0001764_abnormal_homeostasis0.50676517
73MP0003137_abnormal_impulse_conducting0.50589119
74MP0002272_abnormal_nervous_system0.50017913
75MP0003329_amyloid_beta_deposits0.49477833
76MP0003699_abnormal_female_reproductive0.49087222
77MP0001440_abnormal_grooming_behavior0.48681103
78MP0000358_abnormal_cell_content/0.48082561
79MP0010094_abnormal_chromosome_stability0.47809374
80MP0002928_abnormal_bile_duct0.47360516
81MP0003119_abnormal_digestive_system0.46978502
82MP0000569_abnormal_digit_pigmentation0.46774406
83MP0003880_abnormal_central_pattern0.46280336
84MP0002736_abnormal_nociception_after0.46276438
85MP0002269_muscular_atrophy0.46219472
86MP0001293_anophthalmia0.45751225
87MP0000003_abnormal_adipose_tissue0.44619513
88MP0000470_abnormal_stomach_morphology0.44211780
89MP0009745_abnormal_behavioral_response0.44003360
90MP0006292_abnormal_olfactory_placode0.43813458
91MP0005551_abnormal_eye_electrophysiolog0.41856539
92MP0005535_abnormal_body_temperature0.41692785
93MP0005253_abnormal_eye_physiology0.41411871
94MP0001501_abnormal_sleep_pattern0.41321495
95MP0003950_abnormal_plasma_membrane0.39515973
96MP0000230_abnormal_systemic_arterial0.38690626
97MP0009115_abnormal_fat_cell0.38591308
98MP0006036_abnormal_mitochondrial_physio0.38575130
99MP0000249_abnormal_blood_vessel0.37404076
100MP0000534_abnormal_ureter_morphology0.35596976
101MP0002102_abnormal_ear_morphology0.35349203
102MP0004084_abnormal_cardiac_muscle0.35213573
103MP0001545_abnormal_hematopoietic_system0.34318974
104MP0005397_hematopoietic_system_phenotyp0.34318974
105MP0002971_abnormal_brown_adipose0.34033230
106MP0004782_abnormal_surfactant_physiolog0.33773442
107MP0003936_abnormal_reproductive_system0.33700948
108MP0003635_abnormal_synaptic_transmissio0.33691723
109MP0001299_abnormal_eye_distance/0.33138821
110MP0000566_synostosis0.33021520
111MP0003633_abnormal_nervous_system0.32718555
112MP0005408_hypopigmentation0.32382917
113MP0001119_abnormal_female_reproductive0.31648037
114MP0004133_heterotaxia0.31137630
115MP0005391_vision/eye_phenotype0.30565845
116MP0002139_abnormal_hepatobiliary_system0.29877444
117MP0001968_abnormal_touch/_nociception0.28574293
118MP0009278_abnormal_bone_marrow0.28475153
119MP0004811_abnormal_neuron_physiology0.28005404
120MP0004019_abnormal_vitamin_homeostasis0.28001396
121MP0003111_abnormal_nucleus_morphology0.27094713
122MP0003942_abnormal_urinary_system0.26533862
123MP0004145_abnormal_muscle_electrophysio0.25140763
124MP0003879_abnormal_hair_cell0.25050024
125MP0000604_amyloidosis0.25029136
126MP0003631_nervous_system_phenotype0.23967671
127MP0006035_abnormal_mitochondrial_morpho0.22858339
128MP0003861_abnormal_nervous_system0.22699366
129MP0002152_abnormal_brain_morphology0.21512935
130MP0002295_abnormal_pulmonary_circulatio0.21503215
131MP0002169_no_abnormal_phenotype0.21360742
132MP0002873_normal_phenotype0.21120164
133MP0001730_embryonic_growth_arrest0.20915107
134MP0004742_abnormal_vestibular_system0.20603335
135MP0003948_abnormal_gas_homeostasis0.20054522
136MP0003786_premature_aging0.20048044
137MP0008875_abnormal_xenobiotic_pharmacok0.19688685
138MP0001849_ear_inflammation0.18552817
139MP0005319_abnormal_enzyme/_coenzyme0.17273925
140MP0002693_abnormal_pancreas_physiology0.17141030
141MP0004270_analgesia0.16983929
142MP0005365_abnormal_bile_salt0.16830873
143MP0004043_abnormal_pH_regulation0.16629180
144MP0010307_abnormal_tumor_latency0.15979090
145MP0008057_abnormal_DNA_replication0.15813306
146MP0002229_neurodegeneration0.15788677
147MP0008569_lethality_at_weaning0.15754476
148MP0002132_abnormal_respiratory_system0.15198586
149MP0001727_abnormal_embryo_implantation0.14839757
150MP0002092_abnormal_eye_morphology0.14677131
151MP0000313_abnormal_cell_death0.14578198
152MP0005375_adipose_tissue_phenotype0.14080781
153MP0000001_mammalian_phenotype0.13164318
154MP0002118_abnormal_lipid_homeostasis0.13027592
155MP0005195_abnormal_posterior_eye0.12728856
156MP0002084_abnormal_developmental_patter0.12721259
157MP0005423_abnormal_somatic_nervous0.12183176
158MP0001661_extended_life_span0.12011500
159MP0000751_myopathy0.11918948
160MP0008961_abnormal_basal_metabolism0.11722172

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.34770827
2Abnormal respiratory motile cilium morphology (HP:0005938)9.31960615
3Abnormal respiratory epithelium morphology (HP:0012253)9.31960615
4Severe visual impairment (HP:0001141)8.20728673
5Abnormal ciliary motility (HP:0012262)7.51646254
6Rhinitis (HP:0012384)7.41329516
7Chronic bronchitis (HP:0004469)7.32855466
8Infertility (HP:0000789)6.81958694
9Nasal polyposis (HP:0100582)6.35326726
10Abnormality of the nasal mucosa (HP:0000433)5.22084681
11Bony spicule pigmentary retinopathy (HP:0007737)5.04098530
12Attenuation of retinal blood vessels (HP:0007843)4.96786519
13Male infertility (HP:0003251)4.94548470
14Chronic hepatic failure (HP:0100626)4.92460268
15Bronchitis (HP:0012387)4.60466814
16Bronchiectasis (HP:0002110)4.40848118
17Resting tremor (HP:0002322)4.39249339
18Hyperkalemia (HP:0002153)4.36852518
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.20902345
20Nephronophthisis (HP:0000090)4.14947878
21Hypoplastic ischia (HP:0003175)4.06141551
22Abnormality of macular pigmentation (HP:0008002)3.92483669
23Abnormal rod and cone electroretinograms (HP:0008323)3.86698250
24Enlarged epiphyses (HP:0010580)3.85289734
25Cone-rod dystrophy (HP:0000548)3.78774139
26Facial shape deformation (HP:0011334)3.77041511
27Potter facies (HP:0002009)3.77041511
28Abnormal spermatogenesis (HP:0008669)3.66665797
29Aplasia/Hypoplasia of the earlobes (HP:0009906)3.66249319
30Abnormality of the ischium (HP:0003174)3.63515086
31Recurrent sinusitis (HP:0011108)3.42616947
32Recurrent otitis media (HP:0000403)3.29775665
33Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.22548029
34Progressive sensorineural hearing impairment (HP:0000408)3.13590450
35Abnormality of the renal medulla (HP:0100957)3.12834899
36Hypoplasia of the thymus (HP:0000778)3.11278981
37Hypoalphalipoproteinemia (HP:0003233)3.00039173
38Tubulointerstitial nephritis (HP:0001970)2.96285193
39Unilateral renal agenesis (HP:0000122)2.88723507
40Postural instability (HP:0002172)2.86915932
41Recurrent bronchitis (HP:0002837)2.78874380
42Amelogenesis imperfecta (HP:0000705)2.72853462
43Abnormality of the aortic arch (HP:0012303)2.67439397
44Progressive cerebellar ataxia (HP:0002073)2.65913006
45Portal hypertension (HP:0001409)2.64997796
46Abnormality of potassium homeostasis (HP:0011042)2.63145631
47Abnormality of midbrain morphology (HP:0002418)2.62312096
48Molar tooth sign on MRI (HP:0002419)2.62312096
49Medial flaring of the eyebrow (HP:0010747)2.56379125
50Tubular atrophy (HP:0000092)2.56256609
51Abnormality of dental color (HP:0011073)2.54742637
52Impulsivity (HP:0100710)2.53479335
53Generalized aminoaciduria (HP:0002909)2.50758875
54Menstrual irregularities (HP:0000858)2.48412354
55Insulin-resistant diabetes mellitus (HP:0000831)2.47335760
56Renovascular hypertension (HP:0100817)2.44883540
57Abnormality of the hepatic vasculature (HP:0006707)2.43247123
58Tubulointerstitial abnormality (HP:0001969)2.42181704
59Abnormality of the costochondral junction (HP:0000919)2.41698801
60Flattened epiphyses (HP:0003071)2.34560732
61Abnormal gallbladder physiology (HP:0012438)2.32025757
62Cholecystitis (HP:0001082)2.32025757
63Azoospermia (HP:0000027)2.29291218
64Epiphyseal dysplasia (HP:0002656)2.28279725
65Absent epiphyses (HP:0010577)2.27946297
66Ventricular tachycardia (HP:0004756)2.27045416
67Gonadotropin excess (HP:0000837)2.19669259
68Osteomalacia (HP:0002749)2.15613300
69Focal segmental glomerulosclerosis (HP:0000097)2.14351518
70Abnormality of the parathyroid morphology (HP:0011766)2.14093911
71Abnormality of the epiphysis of the femoral head (HP:0010574)2.11589787
72Polyuria (HP:0000103)2.10826545
73Dyschromatopsia (HP:0007641)2.10670970
74Abnormality of the pubic bones (HP:0003172)2.02939819
75Hyponatremia (HP:0002902)2.02763052
76Dynein arm defect of respiratory motile cilia (HP:0012255)13.5829104
77Absent/shortened dynein arms (HP:0200106)13.5829104
78Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1162304
79Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.99709384
80Abnormality of femoral epiphyses (HP:0006499)1.99709384
81Progressive hearing impairment (HP:0001730)1.99415053
82Intellectual disability, moderate (HP:0002342)1.96820210
83Hypophosphatemic rickets (HP:0004912)1.95786123
84Tetany (HP:0001281)1.92913951
85Decreased central vision (HP:0007663)1.92851406
86Widely patent fontanelles and sutures (HP:0004492)1.91081504
87Increased purine levels (HP:0004368)1.89824980
88Hyperuricemia (HP:0002149)1.89824980
89Flat capital femoral epiphysis (HP:0003370)1.87212472
90Abnormality of the femoral head (HP:0003368)1.86568666
91Tubulointerstitial fibrosis (HP:0005576)1.86437612
92Choroideremia (HP:0001139)1.86080656
93Spastic tetraparesis (HP:0001285)1.84337051
94Recurrent pneumonia (HP:0006532)1.83877844
95Myokymia (HP:0002411)1.83176357
96Failure to thrive in infancy (HP:0001531)1.82668237
97Postaxial foot polydactyly (HP:0001830)1.81893405
98Recurrent corneal erosions (HP:0000495)1.78807060
99Bradycardia (HP:0001662)1.76834771
100Pendular nystagmus (HP:0012043)1.76065606
101Stage 5 chronic kidney disease (HP:0003774)1.75586584
102Mixed hearing impairment (HP:0000410)1.75149165
103Asymmetric septal hypertrophy (HP:0001670)1.73073682
104Bile duct proliferation (HP:0001408)1.72189160
105Abnormal biliary tract physiology (HP:0012439)1.72189160
106Heterotopia (HP:0002282)1.71075141
107Abnormal drinking behavior (HP:0030082)1.69517908
108Polydipsia (HP:0001959)1.69517908
109Congenital hepatic fibrosis (HP:0002612)1.69033022
110Abnormality of the renal cortex (HP:0011035)1.63611967
111Abnormality of renal excretion (HP:0011036)1.63151225
112Hemorrhage of the eye (HP:0011885)1.59229652
113Short ribs (HP:0000773)1.54627694
114Bell-shaped thorax (HP:0001591)1.53235419
115Oculomotor apraxia (HP:0000657)1.52423157
116Abnormality of the dental root (HP:0006486)1.51658711
117Taurodontia (HP:0000679)1.51658711
118Abnormality of permanent molar morphology (HP:0011071)1.51658711
119Aplasia/Hypoplasia of the lens (HP:0008063)1.50830757
120Bundle branch block (HP:0011710)1.49931692
121Hypoplasia of the capital femoral epiphysis (HP:0003090)1.48631901
122Postaxial hand polydactyly (HP:0001162)1.45817134
123Congenital primary aphakia (HP:0007707)1.45182859
124Gait imbalance (HP:0002141)1.44935936
125Double outlet right ventricle (HP:0001719)1.44289229
126Congenital malformation of the right heart (HP:0011723)1.44289229
127Chronic sinusitis (HP:0011109)1.44177877
128Decreased electroretinogram (ERG) amplitude (HP:0000654)1.41777142
129Neurofibrillary tangles (HP:0002185)1.41040185
130Abnormality of molar (HP:0011077)1.40247877
131Abnormality of molar morphology (HP:0011070)1.40247877
132Cystic liver disease (HP:0006706)1.40213235
133Abnormality of the dental pulp (HP:0006479)1.40177655
134Constricted visual fields (HP:0001133)1.39238847
135Fibular hypoplasia (HP:0003038)1.39034168
136Pancreatic fibrosis (HP:0100732)1.38382204
137Renal dysplasia (HP:0000110)1.38281543
138Abnormality of dentin (HP:0010299)1.36251336
139Facial cleft (HP:0002006)1.32681977
140Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.32507229
141Abnormal urine output (HP:0012590)1.31271582
142Abnormality of saccadic eye movements (HP:0000570)1.29658811
143Abnormality of the lower motor neuron (HP:0002366)1.29007395
144Deformed sella turcica (HP:0002681)1.26101875
145Easy fatigability (HP:0003388)1.24279067
146Aplasia/Hypoplasia of the tongue (HP:0010295)1.22312796
147Microglossia (HP:0000171)1.22291293
148Nephrogenic diabetes insipidus (HP:0009806)1.21673881
149Cerebral inclusion bodies (HP:0100314)1.20463834
150Absent frontal sinuses (HP:0002688)1.19340240
151Sensory axonal neuropathy (HP:0003390)1.19238459
152Abnormality of ocular smooth pursuit (HP:0000617)1.18696718
153True hermaphroditism (HP:0010459)1.18454226
154Cerebellar dysplasia (HP:0007033)1.18380948
155Abnormality of the neuromuscular junction (HP:0003398)1.18064209
156Fatigable weakness (HP:0003473)1.18064209
157Hemiparesis (HP:0001269)1.17395863
158Truncal obesity (HP:0001956)1.17286404
159Optic nerve hypoplasia (HP:0000609)1.16722517
160Nephropathy (HP:0000112)1.16464696
161Hypercholesterolemia (HP:0003124)1.16288274
162Exercise-induced myalgia (HP:0003738)1.16184532
163Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.15888838

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.71787396
2PDK38.71787396
3TESK15.70718081
4PDK25.65768269
5DDR24.99490739
6PRKD34.75961056
7INSRR4.51988962
8ICK4.09960413
9MAP4K23.58336994
10BRD43.38799045
11PLK23.19601429
12PTK2B2.16566498
13WNK41.98050301
14STK391.89749377
15PIK3CG1.86964815
16PNCK1.80634968
17MST1R1.79569760
18STK381.63933360
19DYRK1B1.49523600
20NEK21.39646011
21PDK11.19629292
22CDK71.18125042
23KSR21.00081399
24AKT30.92678168
25MAP3K90.85714546
26CAMK1D0.85425516
27DYRK30.83180674
28TYRO30.82333426
29IRAK10.80220324
30LATS20.76546578
31WNK10.72920468
32MAPK150.71266596
33PDPK10.70413529
34LMTK20.68217668
35PRKAA20.67240060
36RIPK40.66146258
37PASK0.63874553
38RPS6KA20.63382754
39BMPR1B0.62933767
40MAP2K60.62399177
41CCNB10.60771000
42SIK20.60527804
43MAP3K110.58311838
44UHMK10.58148197
45CAMK10.56780931
46LATS10.56161503
47CHEK20.55986610
48TTK0.55968667
49TIE10.55562569
50MAP2K20.54750996
51STK30.54244095
52MAP3K20.53257676
53ROCK10.51905200
54EEF2K0.50937597
55CAMK1G0.49610912
56TESK20.48242359
57CDK30.47276717
58MAP3K80.46110525
59IRAK20.44458040
60PINK10.43836143
61STK38L0.43588863
62SGK2230.39274403
63SGK4940.39274403
64MAPK10.37953595
65PAK10.37712067
66CHEK10.37461806
67CAMK40.37395734
68MARK10.36875942
69MUSK0.36492997
70PLK40.34456868
71NTRK20.33338768
72RPS6KL10.32429968
73RPS6KC10.32429968
74MAP3K70.31909682
75PRKCG0.31680550
76RPS6KA60.29438157
77WEE10.28757507
78MET0.27714884
79MAP3K100.26765846
80PAK20.26091049
81ATM0.25705129
82MAPK100.23202778
83NEK60.22684088
84SGK10.22265726
85BRSK20.22241733
86MTOR0.22168267
87NTRK30.21464264
88MARK20.21028232
89MAPK140.20836354
90MAPKAPK50.20343793
91ATR0.19970361
92OXSR10.19925746
93CAMKK10.19112541
94PRKAA10.17144252
95PRKCZ0.16623182
96PAK40.16602464
97CDC70.15783829
98TNK20.14792888
99ACVR1B0.14783221
100AKT10.14688680
101RPS6KB10.14531619
102FRK0.14117605
103ARAF0.13741579
104JAK30.13224664
105CDK150.12507882
106PLK10.12375168
107PRKCQ0.12145730
108FER0.12094774
109PRKG20.11733272
110BLK0.11129905
111CDK180.10134670
112PRKCE0.09940023
113MAPK110.09660942
114SGK20.09651338
115MAP2K70.09420179
116BRSK10.08833021
117CDK11A0.08748181
118GSK3B0.06715455
119CDK140.06304089
120CSNK2A10.06239290
121BRAF0.06059013
122RPS6KA10.06018509
123MARK30.05643903
124PKN10.05472372
125PRKG10.04699100
126CDK120.04639983
127STK100.04086978
128CAMK2A0.03876945
129CSNK1D0.03722568
130CDK60.03486668
131PRKACG0.03199210
132CDK20.02872655
133CSNK2A20.02821084
134CDK10.02454475
135MAP3K40.02237997
136PRKCD0.01981730
137STK110.01798316
138YES10.01793288
139PRKCB0.01659695
140MAPK80.01449828
141MAP3K50.01250548
142ZAP700.01131213
143WNK30.00739450
144CSF1R0.00257623
145PRKCA0.00245703
146PRKACA-0.0287387
147PRKDC-0.0281154
148CDK4-0.0260212
149MAP3K1-0.0219889
150PRKACB-0.0169836
151RPS6KA3-0.0136874
152PDGFRB-0.0103316
153PIM1-0.0076366
154EGFR-0.0041200

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.99095016
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.59806745
3Fatty acid biosynthesis_Homo sapiens_hsa000614.39935676
4Olfactory transduction_Homo sapiens_hsa047403.76329736
5Pyruvate metabolism_Homo sapiens_hsa006203.48217060
6Vitamin B6 metabolism_Homo sapiens_hsa007503.44383286
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.96983572
8Linoleic acid metabolism_Homo sapiens_hsa005912.88200248
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.86013660
10Butanoate metabolism_Homo sapiens_hsa006502.66657206
11Propanoate metabolism_Homo sapiens_hsa006402.63978110
12Glucagon signaling pathway_Homo sapiens_hsa049222.56203733
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.36912452
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.30618623
15Basal transcription factors_Homo sapiens_hsa030222.22515267
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.07475543
17Glycerolipid metabolism_Homo sapiens_hsa005611.98092758
18Selenocompound metabolism_Homo sapiens_hsa004501.90945821
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.82983028
20PPAR signaling pathway_Homo sapiens_hsa033201.82300326
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.77772277
22Oocyte meiosis_Homo sapiens_hsa041141.76418074
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.72758510
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.68602109
25Type I diabetes mellitus_Homo sapiens_hsa049401.68202410
26Allograft rejection_Homo sapiens_hsa053301.67518044
27Phenylalanine metabolism_Homo sapiens_hsa003601.66959596
28Autoimmune thyroid disease_Homo sapiens_hsa053201.66455110
29Pentose phosphate pathway_Homo sapiens_hsa000301.65657434
30Type II diabetes mellitus_Homo sapiens_hsa049301.60452428
31Mineral absorption_Homo sapiens_hsa049781.60361195
32Fructose and mannose metabolism_Homo sapiens_hsa000511.57230649
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.57205560
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53458435
35Graft-versus-host disease_Homo sapiens_hsa053321.52139282
36Dorso-ventral axis formation_Homo sapiens_hsa043201.46570782
37Amphetamine addiction_Homo sapiens_hsa050311.43963648
38Carbon metabolism_Homo sapiens_hsa012001.42228328
39Fat digestion and absorption_Homo sapiens_hsa049751.39239757
40Ether lipid metabolism_Homo sapiens_hsa005651.36060144
41Fatty acid degradation_Homo sapiens_hsa000711.32686833
42Fatty acid metabolism_Homo sapiens_hsa012121.31467685
43Viral myocarditis_Homo sapiens_hsa054161.29937273
44Cardiac muscle contraction_Homo sapiens_hsa042601.29040584
45Arginine and proline metabolism_Homo sapiens_hsa003301.28649972
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24801920
47Fanconi anemia pathway_Homo sapiens_hsa034601.21206491
48Antigen processing and presentation_Homo sapiens_hsa046121.10826783
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.09505861
50Renin secretion_Homo sapiens_hsa049241.08481217
51Phototransduction_Homo sapiens_hsa047441.02615729
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01219744
53Purine metabolism_Homo sapiens_hsa002301.01000015
54Huntingtons disease_Homo sapiens_hsa050160.98175417
55mRNA surveillance pathway_Homo sapiens_hsa030150.97462136
56Collecting duct acid secretion_Homo sapiens_hsa049660.96562251
57Glutathione metabolism_Homo sapiens_hsa004800.96440289
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95280597
59Arginine biosynthesis_Homo sapiens_hsa002200.95022606
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94620561
61Biosynthesis of amino acids_Homo sapiens_hsa012300.91417471
62Morphine addiction_Homo sapiens_hsa050320.89468203
63Nicotine addiction_Homo sapiens_hsa050330.88035894
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87520897
65Insulin secretion_Homo sapiens_hsa049110.86886803
66Bile secretion_Homo sapiens_hsa049760.82872308
67Hedgehog signaling pathway_Homo sapiens_hsa043400.80456561
68Chemical carcinogenesis_Homo sapiens_hsa052040.80033533
69RNA transport_Homo sapiens_hsa030130.79962741
70Thyroid hormone synthesis_Homo sapiens_hsa049180.79771515
71Influenza A_Homo sapiens_hsa051640.74544399
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.73778215
73Estrogen signaling pathway_Homo sapiens_hsa049150.73620529
74Renin-angiotensin system_Homo sapiens_hsa046140.73177999
75Tyrosine metabolism_Homo sapiens_hsa003500.72910063
76Arachidonic acid metabolism_Homo sapiens_hsa005900.72677663
77Long-term potentiation_Homo sapiens_hsa047200.71158451
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.68505125
79Retinol metabolism_Homo sapiens_hsa008300.67207024
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65641810
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.60455570
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60040750
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59774960
84Legionellosis_Homo sapiens_hsa051340.59607279
85Pancreatic secretion_Homo sapiens_hsa049720.57947951
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57526204
87Salivary secretion_Homo sapiens_hsa049700.56853758
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56128748
89Inositol phosphate metabolism_Homo sapiens_hsa005620.55369022
90Calcium signaling pathway_Homo sapiens_hsa040200.55088099
91Protein digestion and absorption_Homo sapiens_hsa049740.54206128
92Systemic lupus erythematosus_Homo sapiens_hsa053220.53466704
93Synaptic vesicle cycle_Homo sapiens_hsa047210.51934228
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51485834
95Tight junction_Homo sapiens_hsa045300.51439915
96Sulfur metabolism_Homo sapiens_hsa009200.50686031
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50615710
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48826740
99Gastric acid secretion_Homo sapiens_hsa049710.48056220
100ABC transporters_Homo sapiens_hsa020100.47055889
101Serotonergic synapse_Homo sapiens_hsa047260.45142441
102Endocytosis_Homo sapiens_hsa041440.45089371
103MAPK signaling pathway_Homo sapiens_hsa040100.44922097
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.44177847
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42244901
106Taste transduction_Homo sapiens_hsa047420.41426090
107AMPK signaling pathway_Homo sapiens_hsa041520.41166821
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.39096297
109Metabolic pathways_Homo sapiens_hsa011000.38941225
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38563482
111ECM-receptor interaction_Homo sapiens_hsa045120.35828106
112Cholinergic synapse_Homo sapiens_hsa047250.34769293
113cAMP signaling pathway_Homo sapiens_hsa040240.34273552
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34119108
115GABAergic synapse_Homo sapiens_hsa047270.33415093
116Circadian entrainment_Homo sapiens_hsa047130.32990264
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32198305
118Oxytocin signaling pathway_Homo sapiens_hsa049210.26649328
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26584150
120VEGF signaling pathway_Homo sapiens_hsa043700.26504795
121Acute myeloid leukemia_Homo sapiens_hsa052210.26488918
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.26019344
123Adherens junction_Homo sapiens_hsa045200.24352195
124Alcoholism_Homo sapiens_hsa050340.22282368
125Pyrimidine metabolism_Homo sapiens_hsa002400.21742608
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21604870
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.19927488
128Cocaine addiction_Homo sapiens_hsa050300.19474281
129Prolactin signaling pathway_Homo sapiens_hsa049170.19334942
130Viral carcinogenesis_Homo sapiens_hsa052030.19050438
131Circadian rhythm_Homo sapiens_hsa047100.18742343
132Nitrogen metabolism_Homo sapiens_hsa009100.18599728
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.16385700
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.15791061
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.15555497
136N-Glycan biosynthesis_Homo sapiens_hsa005100.08122943
137HIF-1 signaling pathway_Homo sapiens_hsa040660.06868431
138Wnt signaling pathway_Homo sapiens_hsa043100.06617799
139Salmonella infection_Homo sapiens_hsa051320.06118124
140Glutamatergic synapse_Homo sapiens_hsa047240.04606775
141B cell receptor signaling pathway_Homo sapiens_hsa046620.02340175
142Basal cell carcinoma_Homo sapiens_hsa052170.01772057

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