RNF135

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline metabolic process (GO:0006560)8.31017007
2transcription from mitochondrial promoter (GO:0006390)7.87294542
3DNA deamination (GO:0045006)7.47868226
4replication fork processing (GO:0031297)7.17039110
5positive regulation of protein homooligomerization (GO:0032464)7.14129886
6embryonic process involved in female pregnancy (GO:0060136)6.99277945
7regulation of integrin activation (GO:0033623)6.31588458
8oxidative demethylation (GO:0070989)5.93990866
9regulation of protein homooligomerization (GO:0032462)5.79974024
10maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.76615016
11cellular response to zinc ion (GO:0071294)5.38013548
12poly(A)+ mRNA export from nucleus (GO:0016973)5.27060366
13mitochondrial DNA metabolic process (GO:0032042)4.91282452
14neutrophil activation involved in immune response (GO:0002283)4.90449868
15positive regulation of gamma-delta T cell activation (GO:0046645)4.84451535
16viral mRNA export from host cell nucleus (GO:0046784)4.83879586
17establishment of apical/basal cell polarity (GO:0035089)4.77639124
18cellular response to ATP (GO:0071318)4.70724080
19glutamine family amino acid biosynthetic process (GO:0009084)4.70561581
20DNA strand renaturation (GO:0000733)4.69055540
21somatic hypermutation of immunoglobulin genes (GO:0016446)4.59295072
22somatic diversification of immune receptors via somatic mutation (GO:0002566)4.59295072
23immunoglobulin mediated immune response (GO:0016064)4.53960620
24positive regulation by symbiont of host defense response (GO:0052509)4.34596785
25modulation by symbiont of host defense response (GO:0052031)4.34596785
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.34596785
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.34596785
28positive regulation by organism of defense response of other organism involved in symbiotic interact4.34596785
29modulation by symbiont of host immune response (GO:0052553)4.34596785
30negative regulation of interleukin-12 production (GO:0032695)4.28837353
31regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.27710923
32macrophage activation involved in immune response (GO:0002281)4.26453067
33negative regulation of fatty acid biosynthetic process (GO:0045717)4.26406160
34positive regulation of protein oligomerization (GO:0032461)4.22799904
35response to peptidoglycan (GO:0032494)4.18014410
36antigen processing and presentation of endogenous antigen (GO:0019883)4.13703663
37embryonic placenta development (GO:0001892)4.13020411
38negative regulation of JAK-STAT cascade (GO:0046426)4.12408412
39regulation of B cell receptor signaling pathway (GO:0050855)3.99233123
40establishment of monopolar cell polarity (GO:0061162)3.96517445
41establishment or maintenance of monopolar cell polarity (GO:0061339)3.96517445
42DNA integration (GO:0015074)3.95670771
43telomere maintenance via semi-conservative replication (GO:0032201)3.95142709
44positive regulation of developmental pigmentation (GO:0048087)3.93569241
45formation of translation preinitiation complex (GO:0001731)3.92780563
46mitotic G1 DNA damage checkpoint (GO:0031571)3.91504064
47negative regulation of cell killing (GO:0031342)3.88567911
48negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.88567911
49sulfur amino acid catabolic process (GO:0000098)3.87627102
50mRNA cleavage (GO:0006379)3.82893868
51base-excision repair (GO:0006284)3.81801840
52establishment of protein localization to mitochondrial membrane (GO:0090151)3.81460554
53antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.76465966
54negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.75969334
55negative regulation of cell cycle arrest (GO:0071157)3.73999815
56positive regulation of antigen processing and presentation (GO:0002579)3.72835965
57positive regulation of B cell differentiation (GO:0045579)3.72302434
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.71652709
59mitochondrial RNA metabolic process (GO:0000959)3.69795832
60regulation of gamma-delta T cell activation (GO:0046643)3.68686435
61regulation of antigen processing and presentation (GO:0002577)3.67506539
62base-excision repair, AP site formation (GO:0006285)3.66573458
63regulation of interferon-beta biosynthetic process (GO:0045357)3.66355477
64microglial cell activation (GO:0001774)3.64154303
65cellular extravasation (GO:0045123)3.63204335
66detection of other organism (GO:0098543)3.62520626
67regulation of protein oligomerization (GO:0032459)3.59566649
68B cell mediated immunity (GO:0019724)3.54987531
69detection of bacterium (GO:0016045)3.49784726
70nucleotide-excision repair, DNA gap filling (GO:0006297)3.49400490
71pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.48870737
72mitotic G1/S transition checkpoint (GO:0044819)3.48303539
73GDP-mannose metabolic process (GO:0019673)3.45756253
74non-recombinational repair (GO:0000726)3.45330511
75double-strand break repair via nonhomologous end joining (GO:0006303)3.45330511
76myeloid cell activation involved in immune response (GO:0002275)3.44457859
77alkaloid metabolic process (GO:0009820)3.42967483
78antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.42936419
79regulation of mast cell degranulation (GO:0043304)3.42857223
80positive regulation of mast cell activation (GO:0033005)3.40819461
81negative regulation of protein oligomerization (GO:0032460)3.37246938
82very-low-density lipoprotein particle assembly (GO:0034379)3.31800337
83telomere maintenance via recombination (GO:0000722)3.30823875
84membrane invagination (GO:0010324)3.29719727
85neutrophil activation (GO:0042119)3.29306932
86G1 DNA damage checkpoint (GO:0044783)3.28923046
87meiotic chromosome segregation (GO:0045132)3.28909944
88regulation of podosome assembly (GO:0071801)3.28323864
89regulation of gamma-delta T cell differentiation (GO:0045586)3.28119870
90glial cell migration (GO:0008347)3.27367245
91positive regulation of mast cell activation involved in immune response (GO:0033008)3.27319980
92positive regulation of mast cell degranulation (GO:0043306)3.27319980
93respiratory burst (GO:0045730)3.25644315
94negative regulation of tumor necrosis factor production (GO:0032720)3.23627487
95regulation of mast cell activation (GO:0033003)3.20734763
96positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.20554689
97DNA ligation (GO:0006266)3.20528487
98macrophage activation (GO:0042116)3.18954578
99regulation of mast cell activation involved in immune response (GO:0033006)3.18278312
100positive regulation by host of viral transcription (GO:0043923)3.18140016
101regulation of double-strand break repair via homologous recombination (GO:0010569)3.15861351
102granulocyte activation (GO:0036230)3.14326567
103regulation of mitochondrial depolarization (GO:0051900)3.13065032
104negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.11499780
105response to host immune response (GO:0052572)3.11349633
106response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.11349633
107face development (GO:0060324)3.10015759
108positive regulation of DNA repair (GO:0045739)3.09425338
109detection of external biotic stimulus (GO:0098581)3.08956510
110positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.08643002
111DNA demethylation (GO:0080111)3.06817730
112regulation of B cell differentiation (GO:0045577)3.06581334
113maturation of 5.8S rRNA (GO:0000460)3.04470715
114DNA topological change (GO:0006265)3.03611771
115DNA double-strand break processing (GO:0000729)3.02827843
116kinetochore assembly (GO:0051382)3.01878353
117regulation of myeloid leukocyte mediated immunity (GO:0002886)3.01154910
118positive regulation of receptor recycling (GO:0001921)2.96065048
119anatomical structure regression (GO:0060033)2.95407524
120negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.95308575
121interferon-gamma-mediated signaling pathway (GO:0060333)2.94296842
122mitochondrial DNA replication (GO:0006264)2.93445408
123spliceosomal tri-snRNP complex assembly (GO:0000244)2.93261162
124pyrimidine nucleotide catabolic process (GO:0006244)2.93037713
125pentose metabolic process (GO:0019321)2.92327343
126regulation of dendritic cell antigen processing and presentation (GO:0002604)2.91984725
127positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.91786361
128positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.91786361
129positive regulation of mitotic sister chromatid separation (GO:1901970)2.91786361
130intestinal cholesterol absorption (GO:0030299)2.91192260
131positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.90552301
132negative regulation of phagocytosis (GO:0050765)2.89582356
133B cell receptor signaling pathway (GO:0050853)2.89514189
134regulation of mononuclear cell migration (GO:0071675)2.87929809
135amino sugar catabolic process (GO:0046348)2.87262665
136regulation of macrophage chemotaxis (GO:0010758)2.85725425
137nuclear envelope reassembly (GO:0031468)2.84927305
138mitotic nuclear envelope reassembly (GO:0007084)2.84927305
139detection of molecule of bacterial origin (GO:0032490)2.84705497
140apoptotic process involved in morphogenesis (GO:0060561)2.84383588
141negative regulation of heart rate (GO:0010459)2.83457099
142regulation of translational fidelity (GO:0006450)2.83070000
143defense response to protozoan (GO:0042832)2.82982410
144regulation of leukocyte degranulation (GO:0043300)2.80636123
145dosage compensation (GO:0007549)2.80118512
146production of molecular mediator involved in inflammatory response (GO:0002532)2.79869900
147activation of Rac GTPase activity (GO:0032863)2.78129765
148negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.78001839
149NIK/NF-kappaB signaling (GO:0038061)2.77878393
150DNA strand elongation involved in DNA replication (GO:0006271)2.76502627
151regulation of hydrogen peroxide-induced cell death (GO:1903205)2.75795847
152detection of biotic stimulus (GO:0009595)2.75733189
153regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.75676182
154response to interferon-beta (GO:0035456)2.73842881
155embryonic camera-type eye development (GO:0031076)2.73789439
156negative regulation of lymphocyte mediated immunity (GO:0002707)2.73605492
157DNA strand elongation (GO:0022616)2.73241406
158negative regulation of Ras GTPase activity (GO:0034261)2.72956371
159leukocyte degranulation (GO:0043299)2.71727422
160termination of RNA polymerase II transcription (GO:0006369)2.71530809
161negative regulation of leukocyte mediated immunity (GO:0002704)2.71219045
162response to host (GO:0075136)2.71144903
163response to host defenses (GO:0052200)2.71144903
164response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.71144903
165hypotonic response (GO:0006971)2.71089660
166cellular response to type I interferon (GO:0071357)2.69989733
167type I interferon signaling pathway (GO:0060337)2.69989733
168regulation of B cell apoptotic process (GO:0002902)2.69781250
169response to type I interferon (GO:0034340)2.69737295
170negative regulation of viral release from host cell (GO:1902187)2.69387267
171negative regulation of response to food (GO:0032096)2.68986121
172negative regulation of appetite (GO:0032099)2.68986121
173N-acetylneuraminate metabolic process (GO:0006054)2.68779088
174mitotic cell cycle arrest (GO:0071850)2.68682512
175regulation of germinal center formation (GO:0002634)2.67942689
176response to xenobiotic stimulus (GO:0009410)2.66563678
177positive regulation of defense response to virus by host (GO:0002230)2.63401962
178regulation of interleukin-8 biosynthetic process (GO:0045414)2.63201032
179response to protozoan (GO:0001562)2.62606187
180negative regulation of cytokine production involved in immune response (GO:0002719)2.62372539
181positive regulation of interferon-alpha production (GO:0032727)2.62344562
182Arp2/3 complex-mediated actin nucleation (GO:0034314)2.62133797
183negative regulation of innate immune response (GO:0045824)2.61853214
184positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.60592401
185positive regulation of T cell mediated cytotoxicity (GO:0001916)2.58600842
186negative regulation of interleukin-6 production (GO:0032715)2.57392754
187neutrophil mediated immunity (GO:0002446)2.56932256
188regulation of interferon-alpha production (GO:0032647)2.55895449
189regulation of T cell mediated cytotoxicity (GO:0001914)2.55132561
190antigen processing and presentation via MHC class Ib (GO:0002475)2.54395444
191negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.54178934
192negative regulation of T-helper cell differentiation (GO:0045623)2.54178934
193negative regulation of T cell mediated immunity (GO:0002710)2.54170842
194positive regulation of type 2 immune response (GO:0002830)2.52419850
195T-helper 1 type immune response (GO:0042088)2.52252686
196leukocyte aggregation (GO:0070486)2.52079087
197positive thymic T cell selection (GO:0045059)2.51476986
198mast cell activation (GO:0045576)2.50810748
199proline biosynthetic process (GO:0006561)10.5677247

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.38304114
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.24744971
3IRF8_27001747_Chip-Seq_BMDM_Mouse3.06226106
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.02114110
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.80933180
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.78022555
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.70561359
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.70561359
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.70561359
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65075644
11VDR_21846776_ChIP-Seq_THP-1_Human2.60061392
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.59738139
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.58139235
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.38389958
15SCL_19346495_ChIP-Seq_HPC-7_Human2.29011876
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27998093
17LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.27402960
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.23326173
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.18183152
20MYB_26560356_Chip-Seq_TH2_Human2.16443046
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.14307187
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14002595
23* PU.1_20513432_ChIP-Seq_Bcells_Mouse2.09788915
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.09759025
25SPI1_23127762_ChIP-Seq_K562_Human2.05917375
26SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.99845057
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.97362411
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97098919
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.95953297
30* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.95195802
31* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.92038997
32* RXR_22158963_ChIP-Seq_LIVER_Mouse1.90907764
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.86608272
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.85020912
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83302420
36VDR_24787735_ChIP-Seq_THP-1_Human1.82830073
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.82115641
38NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.81232494
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.80468074
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.79769480
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78837179
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.77365023
43LXR_22292898_ChIP-Seq_THP-1_Human1.76429046
44RUNX_20019798_ChIP-Seq_JUKART_Human1.76336215
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.75598702
46* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.73816905
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.70147966
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.68114527
49* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.67421636
50TCF3_18692474_ChIP-Seq_MESCs_Mouse1.66348186
51GATA3_26560356_Chip-Seq_TH2_Human1.65327565
52MYB_26560356_Chip-Seq_TH1_Human1.60781564
53* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.60105775
54PPARA_22158963_ChIP-Seq_LIVER_Mouse1.59001612
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58845809
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58050911
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.57968087
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.57196601
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56159170
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55650598
61TCF3_18692474_ChIP-Seq_MEFs_Mouse1.55187998
62RXRA_24833708_ChIP-Seq_LIVER_Mouse1.54471117
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.50327742
64* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48503870
65GATA3_27048872_Chip-Seq_THYMUS_Human1.48249067
66* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48199634
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47011648
68* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.46769692
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.45922508
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.44734110
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41566969
72UTX_26944678_Chip-Seq_JUKART_Human1.40670113
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36709852
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36208731
75GATA1_22025678_ChIP-Seq_K562_Human1.36014070
76FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35174473
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35146854
78NANOG_21062744_ChIP-ChIP_HESCs_Human1.31792975
79THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31369109
80* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30835794
81* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30230263
82SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28881055
83SRF_21415370_ChIP-Seq_HL-1_Mouse1.28863243
84VDR_24763502_ChIP-Seq_THP-1_Human1.28312911
85GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28101528
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28098413
87MYC_22102868_ChIP-Seq_BL_Human1.27100337
88* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26958464
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26776509
90* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26693532
91E2F7_22180533_ChIP-Seq_HELA_Human1.26515349
92* RARB_24833708_ChIP-Seq_LIVER_Mouse1.26211058
93ETS1_21867929_ChIP-Seq_TH2_Mouse1.25572125
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.25023010
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24884304
96* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24544512
97NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.23929082
98* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22657980
99CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20443064
100DCP1A_22483619_ChIP-Seq_HELA_Human1.20200480
101CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20095732
102GATA2_21666600_ChIP-Seq_HMVEC_Human1.19966635
103RARA_24833708_ChIP-Seq_LIVER_Mouse1.19609297
104KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17544088
105* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16259326
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15980426
107GABP_19822575_ChIP-Seq_HepG2_Human1.15807343
108MAF_26560356_Chip-Seq_TH2_Human1.15283462
109ETS1_20019798_ChIP-Seq_JURKAT_Human1.14807828
110SPI1_26923725_Chip-Seq_HPCs_Mouse1.14700697
111STAT1_20625510_ChIP-Seq_HELA_Human1.14378179
112* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13888847
113EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13271132
114* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.13176062
115* LXR_22158963_ChIP-Seq_LIVER_Mouse1.12671473
116RACK7_27058665_Chip-Seq_MCF-7_Human1.11990596
117MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11605266
118CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11361272
119SOX2_18692474_ChIP-Seq_MEFs_Mouse1.10870820
120SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10701818
121CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10592209
122CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10100192
123ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09844340
124CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09363075
125GATA1_19941827_ChIP-Seq_MEL_Mouse1.08522740
126P300_27268052_Chip-Seq_Bcells_Human1.08411991
127DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07509890
128FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07368500
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07112165
130MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06673136
131TFEB_21752829_ChIP-Seq_HELA_Human1.06634333
132SPI1_20517297_ChIP-Seq_HL60_Human1.06128730
133MAF_26560356_Chip-Seq_TH1_Human1.06010987
134POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05436849
135SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04847394
136E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04682799
137BCOR_27268052_Chip-Seq_Bcells_Human1.03901852
138FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03434588
139EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03339935
140SPI1_23547873_ChIP-Seq_NB4_Human1.03083908
141* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.02868768
142RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02522139
143NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02389089
144VDR_23849224_ChIP-Seq_CD4+_Human1.01951672
145THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01728938
146SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01480034
147ELF1_20517297_ChIP-Seq_JURKAT_Human1.00746866
148* PU_27001747_Chip-Seq_BMDM_Mouse1.00684385
149BCL6_27268052_Chip-Seq_Bcells_Human1.00442767
150CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00355141
151ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99274168
152SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99111619
153POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98943719
154ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98562784
155* CTCF_26484167_Chip-Seq_Bcells_Mouse0.97974287
156FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.97969151
157SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91244667
158* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90744297
159RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89716165
160RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89192659
161NANOG_20526341_ChIP-Seq_ESCs_Human0.88583715
162FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88084543
163SMRT_27268052_Chip-Seq_Bcells_Human0.83319260
164* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.82759721
165PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81580013
166CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.81228616
167E2F1_20622854_ChIP-Seq_HELA_Human0.79800326
168GABP_17652178_ChIP-ChIP_JURKAT_Human0.79567875
169SMAD_19615063_ChIP-ChIP_OVARY_Human0.79068621
170GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78636266
171NOTCH1_21737748_ChIP-Seq_TLL_Human0.77775945

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.61431404
2MP0005171_absent_coat_pigmentation4.38977296
3MP0009278_abnormal_bone_marrow4.32057966
4MP0002009_preneoplasia3.07925150
5MP0005671_abnormal_response_to2.85911303
6MP0010030_abnormal_orbit_morphology2.61663202
7MP0005058_abnormal_lysosome_morphology2.55253849
8MP0001545_abnormal_hematopoietic_system2.54930512
9MP0005397_hematopoietic_system_phenotyp2.54930512
10MP0008995_early_reproductive_senescence2.42781850
11MP0005085_abnormal_gallbladder_physiolo2.32503805
12MP0002420_abnormal_adaptive_immunity2.28407756
13MP0001819_abnormal_immune_cell2.25612112
14MP0004233_abnormal_muscle_weight2.24747712
15MP0005365_abnormal_bile_salt2.22262048
16MP0003303_peritoneal_inflammation2.18604183
17MP0005174_abnormal_tail_pigmentation2.17857971
18MP0006082_CNS_inflammation2.12493202
19MP0003172_abnormal_lysosome_physiology2.12407354
20MP0005075_abnormal_melanosome_morpholog2.05574525
21MP0000685_abnormal_immune_system1.98180277
22MP0001533_abnormal_skeleton_physiology1.94658624
23MP0003786_premature_aging1.93956300
24MP0010094_abnormal_chromosome_stability1.85927421
25MP0001845_abnormal_inflammatory_respons1.83889291
26MP0003453_abnormal_keratinocyte_physiol1.71774801
27MP0009764_decreased_sensitivity_to1.65275625
28MP0005310_abnormal_salivary_gland1.63130506
29MP0008469_abnormal_protein_level1.62955962
30MP0008058_abnormal_DNA_repair1.61913960
31MP0000015_abnormal_ear_pigmentation1.60093736
32MP0003890_abnormal_embryonic-extraembry1.59846220
33MP0003763_abnormal_thymus_physiology1.59559300
34MP0003806_abnormal_nucleotide_metabolis1.59050699
35MP0002138_abnormal_hepatobiliary_system1.57924210
36MP0003183_abnormal_peptide_metabolism1.56011347
37MP0000371_diluted_coat_color1.50995537
38MP0004133_heterotaxia1.50787448
39MP0000465_gastrointestinal_hemorrhage1.49435535
40MP0001853_heart_inflammation1.48751395
41MP0000490_abnormal_crypts_of1.46428119
42MP0009840_abnormal_foam_cell1.43342848
43MP0001873_stomach_inflammation1.43026491
44MP0000343_altered_response_to1.42754028
45MP0003300_gastrointestinal_ulcer1.41906801
46MP0002405_respiratory_system_inflammati1.37799267
47MP0002132_abnormal_respiratory_system1.34252716
48MP0004947_skin_inflammation1.32489311
49MP0003656_abnormal_erythrocyte_physiolo1.27897096
50MP0005464_abnormal_platelet_physiology1.27782068
51MP0003191_abnormal_cellular_cholesterol1.27288049
52MP0000470_abnormal_stomach_morphology1.24452956
53MP0003195_calcinosis1.21461331
54MP0000639_abnormal_adrenal_gland1.18771607
55MP0002166_altered_tumor_susceptibility1.16666238
56MP0001835_abnormal_antigen_presentation1.16196514
57MP0002998_abnormal_bone_remodeling1.16033028
58MP0003436_decreased_susceptibility_to1.15258295
59MP0001293_anophthalmia1.14123973
60MP0004957_abnormal_blastocyst_morpholog1.10781168
61MP0000689_abnormal_spleen_morphology1.10594292
62MP0000604_amyloidosis1.09942951
63MP0003283_abnormal_digestive_organ1.09557981
64MP0002019_abnormal_tumor_incidence1.09136252
65MP0004264_abnormal_extraembryonic_tissu1.08627880
66MP0005025_abnormal_response_to1.07862439
67MP0006072_abnormal_retinal_apoptosis1.07477285
68MP0002282_abnormal_trachea_morphology1.07123166
69MP0002249_abnormal_larynx_morphology1.06292825
70MP0004019_abnormal_vitamin_homeostasis1.06047808
71MP0009333_abnormal_splenocyte_physiolog1.05838737
72MP0000858_altered_metastatic_potential1.05623693
73MP0000579_abnormal_nail_morphology1.04901295
74MP0003828_pulmonary_edema1.04464150
75MP0002933_joint_inflammation1.03331332
76MP0004883_abnormal_blood_vessel1.02355339
77MP0002277_abnormal_respiratory_mucosa1.02125671
78MP0009785_altered_susceptibility_to1.01637963
79MP0010155_abnormal_intestine_physiology1.01427228
80MP0002086_abnormal_extraembryonic_tissu1.00838764
81MP0010352_gastrointestinal_tract_polyps1.00781478
82MP0003186_abnormal_redox_activity1.00659853
83MP0003866_abnormal_defecation1.00552789
84MP0002148_abnormal_hypersensitivity_rea0.99457788
85MP0002006_tumorigenesis0.97559825
86MP0003111_abnormal_nucleus_morphology0.97020122
87MP0002254_reproductive_system_inflammat0.96921802
88MP0005166_decreased_susceptibility_to0.96726025
89MP0005076_abnormal_cell_differentiation0.96042911
90MP0005164_abnormal_response_to0.96004013
91MP0002139_abnormal_hepatobiliary_system0.95503204
92MP0001851_eye_inflammation0.94705400
93MP0003448_altered_tumor_morphology0.94644250
94MP0001663_abnormal_digestive_system0.94382841
95MP0003718_maternal_effect0.94366582
96MP0005266_abnormal_metabolism0.93220915
97MP0003075_altered_response_to0.91623322
98MP0001324_abnormal_eye_pigmentation0.90946728
99MP0009763_increased_sensitivity_to0.90594372
100MP0008004_abnormal_stomach_pH0.90053391
101MP0009115_abnormal_fat_cell0.89014173
102MP0000703_abnormal_thymus_morphology0.88690699
103MP0008260_abnormal_autophagy0.88394026
104MP0005390_skeleton_phenotype0.88141537
105MP0002398_abnormal_bone_marrow0.88124788
106MP0001764_abnormal_homeostasis0.87451182
107MP0005360_urolithiasis0.87439130
108MP0008932_abnormal_embryonic_tissue0.86238793
109MP0003724_increased_susceptibility_to0.85733784
110MP0002075_abnormal_coat/hair_pigmentati0.84133458
111MP0001800_abnormal_humoral_immune0.82952732
112MP0002396_abnormal_hematopoietic_system0.82481846
113MP0002653_abnormal_ependyma_morphology0.82317880
114MP0002723_abnormal_immune_serum0.81882350
115MP0001697_abnormal_embryo_size0.81820564
116MP0001790_abnormal_immune_system0.81666113
117MP0005387_immune_system_phenotype0.81666113
118MP0004510_myositis0.81656633
119MP0010307_abnormal_tumor_latency0.81603655
120MP0000609_abnormal_liver_physiology0.80699007
121MP0001186_pigmentation_phenotype0.79844589
122MP0000716_abnormal_immune_system0.78922266
123MP0002419_abnormal_innate_immunity0.78894658
124MP0002452_abnormal_antigen_presenting0.78726856
125MP0008877_abnormal_DNA_methylation0.78557170
126MP0003077_abnormal_cell_cycle0.78328247
127MP0003943_abnormal_hepatobiliary_system0.77904943
128MP0003119_abnormal_digestive_system0.76382680
129MP0005451_abnormal_body_composition0.75925314
130MP0004381_abnormal_hair_follicle0.75501347
131MP0005167_abnormal_blood-brain_barrier0.74608745
132MP0003795_abnormal_bone_structure0.74323351
133MP0002722_abnormal_immune_system0.74242456
134MP0000313_abnormal_cell_death0.73231822
135MP0000598_abnormal_liver_morphology0.72924674
136MP0005332_abnormal_amino_acid0.72827451
137MP0005319_abnormal_enzyme/_coenzyme0.72646738
138MP0002429_abnormal_blood_cell0.71896223
139MP0003045_fibrosis0.71863189
140MP0002060_abnormal_skin_morphology0.71743608
141MP0002269_muscular_atrophy0.71613448
142MP0003567_abnormal_fetal_cardiomyocyte0.70961700
143MP0000462_abnormal_digestive_system0.70250560
144MP0005165_increased_susceptibility_to0.70114749
145MP0005000_abnormal_immune_tolerance0.69765882
146MP0004808_abnormal_hematopoietic_stem0.69545073
147MP0008875_abnormal_xenobiotic_pharmacok0.68959955
148MP0006054_spinal_hemorrhage0.67937867
149MP0005084_abnormal_gallbladder_morpholo0.67261331
150MP0009765_abnormal_xenobiotic_induced0.66265864
151MP0003690_abnormal_glial_cell0.66170469
152MP0001542_abnormal_bone_strength0.64859797
153MP0000249_abnormal_blood_vessel0.64755087
154MP0009643_abnormal_urine_homeostasis0.61434772

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)5.79705094
2Pustule (HP:0200039)5.63337280
3Abnormality of liposaccharide metabolism (HP:0010968)5.34742462
4Abnormality of glycosphingolipid metabolism (HP:0004343)5.34742462
5Abnormality of glycolipid metabolism (HP:0010969)5.34742462
6Poikiloderma (HP:0001029)4.96194442
7Rectovaginal fistula (HP:0000143)4.64578870
8Rectal fistula (HP:0100590)4.64578870
9Recurrent abscess formation (HP:0002722)4.57505534
10Rib fusion (HP:0000902)4.57132067
11Recurrent bacterial skin infections (HP:0005406)4.54066878
12Stomatitis (HP:0010280)4.38119519
13Alopecia of scalp (HP:0002293)4.33128138
14Myositis (HP:0100614)4.28558765
15Vaginal fistula (HP:0004320)4.27038798
16Elevated erythrocyte sedimentation rate (HP:0003565)4.22708058
17Intestinal fistula (HP:0100819)4.16152628
18Increased cerebral lipofuscin (HP:0011813)4.14182247
19Concave nail (HP:0001598)4.13417307
20Turricephaly (HP:0000262)4.12519464
21Eczematoid dermatitis (HP:0000976)4.08926312
22Facial hemangioma (HP:0000329)4.08686559
23Urinary glycosaminoglycan excretion (HP:0003541)4.03810584
24Mucopolysacchariduria (HP:0008155)4.03810584
25Hypochromic microcytic anemia (HP:0004840)4.03368062
26Abnormality of macrophages (HP:0004311)3.99868596
27Increased neuronal autofluorescent lipopigment (HP:0002074)3.93333356
28Abnormality of male internal genitalia (HP:0000022)3.80998767
29Orchitis (HP:0100796)3.79174152
30Albinism (HP:0001022)3.78155367
31Dysostosis multiplex (HP:0000943)3.76834115
32Vacuolated lymphocytes (HP:0001922)3.76518991
33Tongue fasciculations (HP:0001308)3.74280387
34Abnormality of polysaccharide metabolism (HP:0011012)3.73019427
35Abnormality of glycosaminoglycan metabolism (HP:0004371)3.73019427
36Abnormality of mucopolysaccharide metabolism (HP:0011020)3.73019427
37Intestinal atresia (HP:0011100)3.66008043
38Ulnar bowing (HP:0003031)3.65618980
39Mediastinal lymphadenopathy (HP:0100721)3.59003864
40Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.56377596
41Annular pancreas (HP:0001734)3.55694015
42Retrobulbar optic neuritis (HP:0100654)3.50024900
43Optic neuritis (HP:0100653)3.50024900
44Recurrent gram-negative bacterial infections (HP:0005420)3.46542926
45Recurrent fungal infections (HP:0002841)3.45000223
46Abnormal hemoglobin (HP:0011902)3.43579839
47Muscle fibrillation (HP:0010546)3.29913652
48Meningitis (HP:0001287)3.29531027
49Chronic obstructive pulmonary disease (HP:0006510)3.27896820
50Obstructive lung disease (HP:0006536)3.27896820
51Coronal craniosynostosis (HP:0004440)3.25189246
52Recurrent skin infections (HP:0001581)3.17550983
53Anteriorly placed anus (HP:0001545)3.16818887
54Recurrent cutaneous fungal infections (HP:0011370)3.13625074
55Chronic mucocutaneous candidiasis (HP:0002728)3.13625074
56Premature skin wrinkling (HP:0100678)3.13572824
57Abnormal delayed hypersensitivity skin test (HP:0002963)3.12030500
58Pancreatic islet-cell hyperplasia (HP:0004510)3.04879826
59Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.04781149
60Vertebral hypoplasia (HP:0008417)3.04781149
61Male infertility (HP:0003251)3.03048131
62Pulmonary infiltrates (HP:0002113)2.97609800
63Large for gestational age (HP:0001520)2.96659520
64IgA deficiency (HP:0002720)2.92053117
65Orthostatic hypotension (HP:0001278)2.90079136
66Joint stiffness (HP:0001387)2.87326497
67Hypokinesia (HP:0002375)2.84921768
68Premature graying of hair (HP:0002216)2.83360903
69Agammaglobulinemia (HP:0004432)2.83226541
70Lower limb hyperreflexia (HP:0002395)2.80451833
71Loss of speech (HP:0002371)2.79999241
72Encephalitis (HP:0002383)2.77947584
73Panhypogammaglobulinemia (HP:0003139)2.77506083
74Clumsiness (HP:0002312)2.77479573
75Hemoptysis (HP:0002105)2.76653917
76Short humerus (HP:0005792)2.74593619
77Systemic lupus erythematosus (HP:0002725)2.74089891
78Dysautonomia (HP:0002459)2.72856993
79Petechiae (HP:0000967)2.70800994
80Vasculitis (HP:0002633)2.69687798
81Aplasia/hypoplasia of the humerus (HP:0006507)2.67792804
82Alacrima (HP:0000522)2.63280784
83Diaphragmatic weakness (HP:0009113)2.62135542
84Squamous cell carcinoma (HP:0002860)2.60036122
85Absent radius (HP:0003974)2.59384872
86Hematochezia (HP:0002573)2.58570290
87Hypochromic anemia (HP:0001931)2.58122905
88Absent thumb (HP:0009777)2.55153131
89Exertional dyspnea (HP:0002875)2.54883990
90Amyloidosis (HP:0011034)2.49928706
91Polycythemia (HP:0001901)2.49530626
92Urticaria (HP:0001025)2.48066995
93Spontaneous hematomas (HP:0007420)2.47975506
94Autoimmune thrombocytopenia (HP:0001973)2.47012825
95Bifid uvula (HP:0000193)2.46077387
96Broad alveolar ridges (HP:0000187)2.46035275
97Abnormality of the prostate (HP:0008775)2.45138401
98Recurrent viral infections (HP:0004429)2.42321904
99Decreased electroretinogram (ERG) amplitude (HP:0000654)2.41124407
100Growth hormone excess (HP:0000845)2.40959503
101Aplasia involving forearm bones (HP:0009822)2.40650739
102Absent forearm bone (HP:0003953)2.40650739
103Hepatosplenomegaly (HP:0001433)2.40339310
104Aplasia of the musculature (HP:0100854)2.38880886
105Keratoconjunctivitis sicca (HP:0001097)2.36181664
106Mutism (HP:0002300)2.35803454
107Cheilitis (HP:0100825)2.34962552
108Abnormality of aromatic amino acid family metabolism (HP:0004338)2.34227095
109Short chin (HP:0000331)2.31124096
110Capillary hemangiomas (HP:0005306)2.30528558
111Keratoconjunctivitis (HP:0001096)2.30182074
112Abnormality of T cell physiology (HP:0011840)2.29056711
113Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.25873795
114Recurrent bronchitis (HP:0002837)2.25755174
115Hypotrichosis (HP:0001006)2.25082370
116Amelogenesis imperfecta (HP:0000705)2.24992424
117Increased serum ferritin (HP:0003281)2.24161368
118Chest pain (HP:0100749)2.23167858
119Opisthotonus (HP:0002179)2.21817533
120Bulbar palsy (HP:0001283)2.19119673
121Myocardial infarction (HP:0001658)2.19096286
122Congenital hip dislocation (HP:0001374)2.18199361
123Granulocytopenia (HP:0001913)2.17714693
124Progressive neurologic deterioration (HP:0002344)2.17661258
125Hypobetalipoproteinemia (HP:0003563)2.16904665
126Leukocytosis (HP:0001974)2.16152221
127Increased IgE level (HP:0003212)2.16016118
128Abnormality of T cells (HP:0002843)2.15012830
129Cellulitis (HP:0100658)2.15012683
130Inflammation of the large intestine (HP:0002037)2.14378502
131Hypergammaglobulinemia (HP:0010702)2.13938364
132Gingivitis (HP:0000230)2.13794508
133Asymmetric septal hypertrophy (HP:0001670)2.12949243
134T lymphocytopenia (HP:0005403)2.11883532
135Epistaxis (HP:0000421)2.11358854
136Abnormality of T cell number (HP:0011839)2.10874819
137Redundant skin (HP:0001582)2.10182979
138Muscle fiber atrophy (HP:0100295)2.10144777
139Polyneuropathy (HP:0001271)2.09015407
140Type 2 muscle fiber atrophy (HP:0003554)2.08280390
141Abnormality of the aortic arch (HP:0012303)2.07780869
142Bowed forearm bones (HP:0003956)2.07300255
143Bowing of the arm (HP:0006488)2.07300255
144Abnormality of iron homeostasis (HP:0011031)2.06691346
145Prolonged bleeding time (HP:0003010)2.06664455
146Eosinophilia (HP:0001880)2.06340205
147Abnormality of B cell number (HP:0010975)2.05966137
148Thrombocytosis (HP:0001894)2.05441532
149Gastrointestinal inflammation (HP:0004386)2.04918177
150Hypotelorism (HP:0000601)2.03812669
151Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.02884977
152Pulmonary fibrosis (HP:0002206)2.02774518
153Episodic fever (HP:0001954)2.02642503
154Autoimmune hemolytic anemia (HP:0001890)2.02165080
155Recurrent pneumonia (HP:0006532)2.01216257
156Osteomyelitis (HP:0002754)2.00362445
157Chronic sinusitis (HP:0011109)1.99866826
158Abnormality of the pleura (HP:0002103)1.99540689
159Type I transferrin isoform profile (HP:0003642)1.99020701
160Abnormality of transition element cation homeostasis (HP:0011030)1.98373501
161Disinhibition (HP:0000734)1.98144014
162Selective tooth agenesis (HP:0001592)1.96481003
163IgG deficiency (HP:0004315)1.96419973
164Skin rash (HP:0000988)1.95267834
165Decreased lacrimation (HP:0000633)1.94675019
166Basal cell carcinoma (HP:0002671)1.94612124
167Abnormality of the pancreatic islet cells (HP:0006476)1.94462095
168Abnormality of endocrine pancreas physiology (HP:0012093)1.94462095
169Generalized amyotrophy (HP:0003700)1.93743149
170Amniotic constriction ring (HP:0009775)1.92187255
171Abnormality of placental membranes (HP:0011409)1.92187255
172Purpura (HP:0000979)1.91839600
173Gastrointestinal atresia (HP:0002589)1.91513982
174Abnormality of the periventricular white matter (HP:0002518)1.90794553
175Popliteal pterygium (HP:0009756)1.90483477
176Cone-rod dystrophy (HP:0000548)1.90339437
177Gangrene (HP:0100758)1.90305226
178Prostate neoplasm (HP:0100787)1.89955755
179Colitis (HP:0002583)1.88881433
180Increased number of teeth (HP:0011069)1.87887308
181Diminished movement (HP:0002374)1.87875678
182Choanal stenosis (HP:0000452)1.87452889
183Restrictive lung disease (HP:0002091)1.87399941
184Anorexia (HP:0002039)1.86825989
185Premature loss of primary teeth (HP:0006323)1.86232699
186Pulmonary embolism (HP:0002204)1.85892582
187Gingival bleeding (HP:0000225)1.85005793
188Hamartoma (HP:0010566)1.82834590
189Acute lymphatic leukemia (HP:0006721)1.82540267

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.81421650
2ICK5.40163069
3DDR24.52783360
4MAP3K64.46147295
5PINK13.35304695
6MAP3K113.21220340
7MATK3.18036333
8PIM23.12101078
9FGR2.91770742
10RIPK42.74782729
11CSK2.53976095
12YES12.46816976
13TESK22.44304489
14TNK22.35239715
15DAPK12.29720267
16FES2.22041225
17BMX2.19673224
18TRPM72.12057885
19TYRO32.11911323
20PRKD22.04704714
21TGFBR22.03683478
22UHMK12.00857363
23SYK1.86850460
24DYRK1B1.86061359
25MAP4K21.83112807
26CSF1R1.82471863
27MAP2K31.73736347
28PIM11.65899979
29CDK71.58984342
30MAP3K31.54826424
31ACVR1B1.54044657
32GRK61.48666028
33AKT31.45026050
34RPS6KC11.44234571
35RPS6KL11.44234571
36PDGFRA1.41366654
37ADRBK21.37413706
38FRK1.34365652
39RPS6KA61.33273943
40KDR1.32620180
41CDK61.27892655
42ITK1.23473640
43MAPK111.23332165
44GRK71.19383115
45MST41.18117009
46HCK1.15270342
47GSK3A1.09931833
48MARK31.09781137
49PIK3CG1.05120264
50DYRK31.04286457
51CAMKK21.02576571
52PRPF4B0.95452146
53IKBKB0.94308479
54ABL20.92838177
55LYN0.85292926
56BCKDK0.83544377
57VRK20.83350722
58BMPR20.81651728
59CHEK20.80858497
60NUAK10.80048565
61TESK10.79179635
62MAP3K130.78691546
63ERN10.78490038
64HIPK20.78232453
65CDC42BPA0.77665927
66JAK10.76474970
67IRAK10.76111851
68PRKCQ0.75851469
69TLK10.73987757
70NEK90.72513122
71MAP3K100.69839574
72TGFBR10.69089642
73TAOK20.68768120
74MAP3K140.67345815
75TBK10.67300157
76MAP4K10.67085476
77MAP2K60.64101395
78SIK30.63420980
79PLK10.62730008
80MAP3K10.62546516
81TYK20.61640809
82RPS6KB20.61473635
83BLK0.60831758
84PHKG20.60414078
85PHKG10.60414078
86MAP2K20.60032637
87FLT30.59598856
88ADRBK10.59147469
89RPS6KA10.58910771
90TAOK10.57943906
91ERBB30.56379667
92ATR0.55669892
93PTK2B0.53900832
94CDK190.53459050
95EPHA20.52143395
96EGFR0.51514861
97GRK10.50666263
98DAPK20.50361184
99IRAK40.48438124
100CAMK2G0.47929245
101CHUK0.47523832
102CSNK2A10.46865846
103LCK0.46191123
104RAF10.45523366
105MAPK30.45462701
106LRRK20.45116548
107PRKAA10.44851745
108DYRK20.44808845
109TAOK30.43683209
110MTOR0.43612644
111IRAK30.43504366
112LIMK10.42693913
113OXSR10.42583155
114PDK10.42177532
115PBK0.41166296
116RPS6KB10.39983478
117MAPK70.39554848
118EPHB10.38709836
119MAPK40.38032157
120IKBKE0.37580759
121MAPKAPK20.36924874
122KIT0.36883593
123LATS20.36879223
124ZAP700.36022539
125ARAF0.34804018
126PRKCD0.34542815
127PRKAA20.34362104
128NME20.34034534
129CSNK1G10.33922849
130PRKCI0.33855332
131MAP3K50.33691665
132MAPK10.33352952
133ABL10.33114926
134INSRR0.31692548
135PDPK10.31686958
136ZAK0.30985761
137CAMK2B0.30238207
138MAP2K10.29538683
139VRK10.29099539
140BTK0.28992699
141PRKD10.28039162
142STK30.28032381
143CDK20.24360617
144JAK30.23512770
145MAPKAPK30.23443230
146STK40.21231670
147CSNK2A20.20885052
148BUB10.20448000
149CAMK2D0.20107351
150MUSK0.19148734
151TXK0.18340453
152INSR0.17932242
153PDGFRB0.17354436
154STK100.17192453
155JAK20.17155597
156MAPK140.16052312
157TEC0.14237537

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.51908186
2Base excision repair_Homo sapiens_hsa034104.31425558
3Mismatch repair_Homo sapiens_hsa034304.24995371
4DNA replication_Homo sapiens_hsa030303.28835654
5Autoimmune thyroid disease_Homo sapiens_hsa053202.97697213
6Asthma_Homo sapiens_hsa053102.91430726
7Other glycan degradation_Homo sapiens_hsa005112.72217761
8Leishmaniasis_Homo sapiens_hsa051402.64530638
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.48956426
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.39616001
11Folate biosynthesis_Homo sapiens_hsa007902.36123945
12Osteoclast differentiation_Homo sapiens_hsa043802.34849169
13Type I diabetes mellitus_Homo sapiens_hsa049402.31781934
14Antigen processing and presentation_Homo sapiens_hsa046122.30431524
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.16913351
16Rheumatoid arthritis_Homo sapiens_hsa053232.13059043
17Arginine and proline metabolism_Homo sapiens_hsa003302.10305606
18Tuberculosis_Homo sapiens_hsa051522.03283257
19Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02661163
20Hematopoietic cell lineage_Homo sapiens_hsa046402.01564460
21Nucleotide excision repair_Homo sapiens_hsa034201.96720110
22Sulfur relay system_Homo sapiens_hsa041221.87345897
23Homologous recombination_Homo sapiens_hsa034401.85884048
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.77625940
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.71159077
26Fatty acid metabolism_Homo sapiens_hsa012121.68020836
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.65433869
28Primary immunodeficiency_Homo sapiens_hsa053401.55855275
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.52154173
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.51621939
31Phagosome_Homo sapiens_hsa041451.47486170
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.45968766
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45088675
34Fanconi anemia pathway_Homo sapiens_hsa034601.44993423
35Notch signaling pathway_Homo sapiens_hsa043301.43318482
36Malaria_Homo sapiens_hsa051441.41480656
37Circadian rhythm_Homo sapiens_hsa047101.40493966
38Biosynthesis of amino acids_Homo sapiens_hsa012301.36340867
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.35999541
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34888730
41Legionellosis_Homo sapiens_hsa051341.34296698
42Arginine biosynthesis_Homo sapiens_hsa002201.30806901
43Pertussis_Homo sapiens_hsa051331.28245316
44Spliceosome_Homo sapiens_hsa030401.28234812
45Fatty acid elongation_Homo sapiens_hsa000621.27885153
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.22269819
47Toxoplasmosis_Homo sapiens_hsa051451.21738836
48Steroid biosynthesis_Homo sapiens_hsa001001.19548550
49Influenza A_Homo sapiens_hsa051641.18501390
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16846860
51Staphylococcus aureus infection_Homo sapiens_hsa051501.15541519
52SNARE interactions in vesicular transport_Homo sapiens_hsa041301.15461545
53p53 signaling pathway_Homo sapiens_hsa041151.15315753
54Shigellosis_Homo sapiens_hsa051311.15122321
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11639955
56Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10989782
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08406685
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03341411
59One carbon pool by folate_Homo sapiens_hsa006700.98422461
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97766826
61RNA transport_Homo sapiens_hsa030130.95884188
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95595810
63Glutathione metabolism_Homo sapiens_hsa004800.93030392
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.92955068
65Sulfur metabolism_Homo sapiens_hsa009200.91441546
66TNF signaling pathway_Homo sapiens_hsa046680.90948012
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88958909
68Herpes simplex infection_Homo sapiens_hsa051680.88601032
69Chemokine signaling pathway_Homo sapiens_hsa040620.84469064
70Lysosome_Homo sapiens_hsa041420.84060826
71Lysine degradation_Homo sapiens_hsa003100.82415597
72Fructose and mannose metabolism_Homo sapiens_hsa000510.82362714
73mTOR signaling pathway_Homo sapiens_hsa041500.80931316
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.80892511
75Proteasome_Homo sapiens_hsa030500.80429364
76Ribosome_Homo sapiens_hsa030100.78706603
77Selenocompound metabolism_Homo sapiens_hsa004500.78588320
78T cell receptor signaling pathway_Homo sapiens_hsa046600.77838516
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.76885372
80Adherens junction_Homo sapiens_hsa045200.74007883
81mRNA surveillance pathway_Homo sapiens_hsa030150.73859578
82Collecting duct acid secretion_Homo sapiens_hsa049660.73734827
83Hedgehog signaling pathway_Homo sapiens_hsa043400.73460037
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71925998
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71884393
86Peroxisome_Homo sapiens_hsa041460.71626648
87Hepatitis C_Homo sapiens_hsa051600.71469496
88Hippo signaling pathway_Homo sapiens_hsa043900.70869318
89Measles_Homo sapiens_hsa051620.70831857
90Salmonella infection_Homo sapiens_hsa051320.69346917
91Complement and coagulation cascades_Homo sapiens_hsa046100.67748586
92Platelet activation_Homo sapiens_hsa046110.67694723
93Regulation of autophagy_Homo sapiens_hsa041400.67182321
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65054291
95ABC transporters_Homo sapiens_hsa020100.63752561
96Tryptophan metabolism_Homo sapiens_hsa003800.61243067
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61043344
98TGF-beta signaling pathway_Homo sapiens_hsa043500.60904525
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60596966
100Cell cycle_Homo sapiens_hsa041100.60432081
101Allograft rejection_Homo sapiens_hsa053300.56859928
102Apoptosis_Homo sapiens_hsa042100.56812977
103Galactose metabolism_Homo sapiens_hsa000520.55733536
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55436880
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55130613
106Graft-versus-host disease_Homo sapiens_hsa053320.53872914
107Pyrimidine metabolism_Homo sapiens_hsa002400.53263778
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53024347
109RNA polymerase_Homo sapiens_hsa030200.51889348
110Ether lipid metabolism_Homo sapiens_hsa005650.51705870
111Histidine metabolism_Homo sapiens_hsa003400.51396242
112African trypanosomiasis_Homo sapiens_hsa051430.50494385
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50428884
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.50373772
115Starch and sucrose metabolism_Homo sapiens_hsa005000.49638203
116Caffeine metabolism_Homo sapiens_hsa002320.49620199
117Sphingolipid metabolism_Homo sapiens_hsa006000.48124889
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48001571
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.46860933
120Bladder cancer_Homo sapiens_hsa052190.46244702
121Mineral absorption_Homo sapiens_hsa049780.45076944
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.44624528
123Chemical carcinogenesis_Homo sapiens_hsa052040.43339696
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42248465
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42059750
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41870752
127Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41801696
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41764599
129Viral myocarditis_Homo sapiens_hsa054160.41089054
130Arachidonic acid metabolism_Homo sapiens_hsa005900.39681362
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.38097219
132Acute myeloid leukemia_Homo sapiens_hsa052210.36658007
133B cell receptor signaling pathway_Homo sapiens_hsa046620.35349984
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35322602
135Systemic lupus erythematosus_Homo sapiens_hsa053220.35268666
136Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35267777
137Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34449345
138Oxidative phosphorylation_Homo sapiens_hsa001900.33417063
139Retinol metabolism_Homo sapiens_hsa008300.33050991
140Hepatitis B_Homo sapiens_hsa051610.32144153
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31366069
142Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28419134
143Linoleic acid metabolism_Homo sapiens_hsa005910.28346884
144Viral carcinogenesis_Homo sapiens_hsa052030.28151606
145Vitamin digestion and absorption_Homo sapiens_hsa049770.28001266
146Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27780669
147HTLV-I infection_Homo sapiens_hsa051660.27778412
148Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27766814
149Epstein-Barr virus infection_Homo sapiens_hsa051690.27668314
150Vitamin B6 metabolism_Homo sapiens_hsa007500.27526621
151Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27492683
152Endocytosis_Homo sapiens_hsa041440.25406316
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.24534416
154Renin-angiotensin system_Homo sapiens_hsa046140.24235560
155Glycerolipid metabolism_Homo sapiens_hsa005610.24128144
156Phototransduction_Homo sapiens_hsa047440.23759189

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