RNF138P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ATP (GO:0071318)6.83046274
2detection of light stimulus involved in sensory perception (GO:0050962)6.13092115
3detection of light stimulus involved in visual perception (GO:0050908)6.13092115
4protein K63-linked deubiquitination (GO:0070536)5.75489349
5cAMP catabolic process (GO:0006198)5.36852732
6cyclic nucleotide catabolic process (GO:0009214)5.30245977
7UDP-N-acetylglucosamine metabolic process (GO:0006047)5.08645282
8establishment of protein localization to Golgi (GO:0072600)5.04118457
9protein K48-linked deubiquitination (GO:0071108)4.99964183
10RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)4.74489609
11protein targeting to Golgi (GO:0000042)4.58889804
12vitamin transmembrane transport (GO:0035461)4.54835471
13regulation of mRNA 3-end processing (GO:0031440)4.54400150
14glomerular visceral epithelial cell development (GO:0072015)4.46864332
15positive regulation of mRNA 3-end processing (GO:0031442)4.43992787
16regulation of protein kinase A signaling (GO:0010738)4.40364686
17histone mRNA metabolic process (GO:0008334)4.36040426
18dolichol-linked oligosaccharide biosynthetic process (GO:0006488)4.24484876
19retrograde transport, vesicle recycling within Golgi (GO:0000301)4.18597075
20kynurenine metabolic process (GO:0070189)4.15230585
21rRNA catabolic process (GO:0016075)4.13147945
22mitochondrial calcium ion transport (GO:0006851)4.08808917
23maturation of 5.8S rRNA (GO:0000460)4.08325032
24acrosome assembly (GO:0001675)4.06859533
25cell wall macromolecule catabolic process (GO:0016998)4.05695069
26positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.02859626
27sequestering of metal ion (GO:0051238)3.91285848
28magnesium ion transport (GO:0015693)3.90180063
29tryptophan catabolic process (GO:0006569)3.90079328
30indole-containing compound catabolic process (GO:0042436)3.90079328
31indolalkylamine catabolic process (GO:0046218)3.90079328
32glomerular epithelial cell development (GO:0072310)3.89691029
33regulation of mitotic spindle checkpoint (GO:1903504)3.86665808
34regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.86665808
35L-fucose catabolic process (GO:0042355)3.81957710
36fucose catabolic process (GO:0019317)3.81957710
37L-fucose metabolic process (GO:0042354)3.81957710
38prenylation (GO:0097354)3.70983250
39protein prenylation (GO:0018342)3.70983250
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.67141544
41NADH dehydrogenase complex assembly (GO:0010257)3.67141544
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.67141544
43protein localization to Golgi apparatus (GO:0034067)3.63824211
44pyrimidine-containing compound transmembrane transport (GO:0072531)3.54368456
45resolution of meiotic recombination intermediates (GO:0000712)3.52957298
46cGMP metabolic process (GO:0046068)3.43945354
47cell wall macromolecule metabolic process (GO:0044036)3.36352160
48protein-chromophore linkage (GO:0018298)3.36238514
49positive regulation of mRNA processing (GO:0050685)3.30365122
50histone mRNA catabolic process (GO:0071044)3.22845598
51response to hydroperoxide (GO:0033194)3.21908786
52microtubule anchoring (GO:0034453)3.19720719
53attachment of spindle microtubules to kinetochore (GO:0008608)3.18377702
54response to pheromone (GO:0019236)3.16756172
55mRNA cleavage (GO:0006379)3.15156320
56ncRNA catabolic process (GO:0034661)3.13501110
57protein polyglutamylation (GO:0018095)3.11790641
58tryptophan metabolic process (GO:0006568)3.11402697
59regulation of phosphoprotein phosphatase activity (GO:0043666)3.07462660
60alanine transport (GO:0032328)3.06064394
61mitochondrial calcium ion homeostasis (GO:0051560)3.04553395
62microtubule severing (GO:0051013)3.04097511
63regulation of cAMP-mediated signaling (GO:0043949)3.02066130
64indolalkylamine metabolic process (GO:0006586)2.97793952
65negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.97752672
66negative regulation of translation, ncRNA-mediated (GO:0040033)2.97752672
67regulation of translation, ncRNA-mediated (GO:0045974)2.97752672
68artery development (GO:0060840)2.96105435
69mannosylation (GO:0097502)2.92147529
70DNA double-strand break processing (GO:0000729)2.90187560
71peroxisome fission (GO:0016559)2.90095795
72nucleotide-sugar metabolic process (GO:0009225)2.87469221
73calcium ion import (GO:0070509)2.83799598
74DNA replication checkpoint (GO:0000076)2.83706874
75negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.82676390
76isoprenoid biosynthetic process (GO:0008299)2.81233498
77GDP-mannose metabolic process (GO:0019673)2.78411505
78positive regulation of mRNA metabolic process (GO:1903313)2.76783099
79nuclear pore organization (GO:0006999)2.74350742
80aromatic amino acid family catabolic process (GO:0009074)2.72408743
81negative regulation of heart rate (GO:0010459)2.71207695
82adenosine metabolic process (GO:0046085)2.70429132
83membrane budding (GO:0006900)2.68571782
84negative regulation of cytosolic calcium ion concentration (GO:0051481)2.68364900
85cilium morphogenesis (GO:0060271)2.68114416
86exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.68038125
87negative regulation of growth of symbiont in host (GO:0044130)2.67541107
88negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.67541107
89modulation of growth of symbiont involved in interaction with host (GO:0044144)2.67541107
90regulation of growth of symbiont in host (GO:0044126)2.67541107
91double-strand break repair via homologous recombination (GO:0000724)2.67417785
92neural tube formation (GO:0001841)2.63637372
93recombinational repair (GO:0000725)2.63591531
94platelet dense granule organization (GO:0060155)2.60813515
95regulation of cilium movement (GO:0003352)2.60147153
96mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.58956670
97nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.58808618
98protein K11-linked deubiquitination (GO:0035871)2.56555635
99gene silencing by RNA (GO:0031047)2.53259504
100centriole replication (GO:0007099)2.49354609

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.92640030
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.25920563
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.89548901
4VDR_22108803_ChIP-Seq_LS180_Human2.88952727
5EWS_26573619_Chip-Seq_HEK293_Human2.79294021
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.69213173
7GBX2_23144817_ChIP-Seq_PC3_Human2.60967544
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.43808856
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.40594708
10* P300_19829295_ChIP-Seq_ESCs_Human2.39990447
11FUS_26573619_Chip-Seq_HEK293_Human2.33604317
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32219182
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20514198
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.12348268
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.11138399
16AR_21572438_ChIP-Seq_LNCaP_Human2.10967350
17TAF15_26573619_Chip-Seq_HEK293_Human2.02859604
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95486472
19IGF1R_20145208_ChIP-Seq_DFB_Human1.92098890
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85752942
21ZNF274_21170338_ChIP-Seq_K562_Hela1.83958614
22ER_23166858_ChIP-Seq_MCF-7_Human1.77571390
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77241111
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.74364210
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73788234
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71386899
27EZH2_27294783_Chip-Seq_NPCs_Mouse1.68266819
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67126671
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64658103
30SMAD4_21799915_ChIP-Seq_A2780_Human1.63186924
31MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61495134
32BCAT_22108803_ChIP-Seq_LS180_Human1.59822653
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.58746054
34TCF4_22108803_ChIP-Seq_LS180_Human1.57938447
35ELK1_19687146_ChIP-ChIP_HELA_Human1.55423613
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.54828338
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52374838
38CBP_20019798_ChIP-Seq_JUKART_Human1.52374838
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41084202
40STAT3_23295773_ChIP-Seq_U87_Human1.40833810
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.40435069
42TP53_22573176_ChIP-Seq_HFKS_Human1.39470417
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39139578
44TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38317564
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38303905
46* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.38145278
47EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37569778
48NANOG_18555785_Chip-Seq_ESCs_Mouse1.37179891
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36945001
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.36701921
51RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.36651211
52P53_22387025_ChIP-Seq_ESCs_Mouse1.36040754
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35786210
54NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34859714
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.33346878
56CRX_20693478_ChIP-Seq_RETINA_Mouse1.32476184
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.32413728
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32042444
59TCF4_23295773_ChIP-Seq_U87_Human1.31199334
60SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.30686378
61FLI1_21867929_ChIP-Seq_TH2_Mouse1.29978555
62E2F1_18555785_Chip-Seq_ESCs_Mouse1.27771555
63CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26527226
64GABP_17652178_ChIP-ChIP_JURKAT_Human1.24753705
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24677969
66AR_25329375_ChIP-Seq_VCAP_Human1.22258881
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21397985
68KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.18535302
69KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.18535302
70KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.18535302
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17358705
72TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17348266
73OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16889800
74P300_18555785_Chip-Seq_ESCs_Mouse1.16879060
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.16029574
76NANOG_19829295_ChIP-Seq_ESCs_Human1.13974374
77SOX2_19829295_ChIP-Seq_ESCs_Human1.13974374
78MYC_18940864_ChIP-ChIP_HL60_Human1.13916712
79CDX2_22108803_ChIP-Seq_LS180_Human1.13771548
80CMYC_18555785_Chip-Seq_ESCs_Mouse1.13629539
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.13608665
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.13184823
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12632048
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12632048
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12262564
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.11111021
87RUNX2_22187159_ChIP-Seq_PCA_Human1.10778477
88PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.10298749
89SOX2_18555785_Chip-Seq_ESCs_Mouse1.10044014
90TAL1_26923725_Chip-Seq_HPCs_Mouse1.09320093
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07421699
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07417824
93OCT4_18555785_Chip-Seq_ESCs_Mouse1.06808172
94SMAD4_21741376_ChIP-Seq_EPCs_Human1.06776641
95NMYC_18555785_Chip-Seq_ESCs_Mouse1.06631089
96POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05133653
97FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04376051
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03413948
99SMAD3_21741376_ChIP-Seq_HESCs_Human1.03014893
100AR_20517297_ChIP-Seq_VCAP_Human1.01533563

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.04692206
2MP0002009_preneoplasia3.84768111
3MP0000569_abnormal_digit_pigmentation3.83587099
4MP0003890_abnormal_embryonic-extraembry3.73877059
5MP0003806_abnormal_nucleotide_metabolis3.41228826
6MP0005408_hypopigmentation3.33536986
7MP0004145_abnormal_muscle_electrophysio3.05028916
8MP0002938_white_spotting3.00078863
9MP0002638_abnormal_pupillary_reflex2.52253934
10MP0004142_abnormal_muscle_tone2.43098398
11MP0005551_abnormal_eye_electrophysiolog2.16914374
12MP0003195_calcinosis2.12140124
13MP0003880_abnormal_central_pattern2.00085692
14MP0008875_abnormal_xenobiotic_pharmacok1.92625745
15MP0006072_abnormal_retinal_apoptosis1.92067216
16MP0005645_abnormal_hypothalamus_physiol1.88821186
17MP0002006_tumorigenesis1.87263865
18MP0002166_altered_tumor_susceptibility1.86589546
19MP0005174_abnormal_tail_pigmentation1.85904849
20MP0003718_maternal_effect1.73234412
21MP0002396_abnormal_hematopoietic_system1.67738844
22MP0008058_abnormal_DNA_repair1.67672522
23MP0000566_synostosis1.67333916
24MP0002735_abnormal_chemical_nociception1.61540841
25MP0005253_abnormal_eye_physiology1.58753273
26MP0006292_abnormal_olfactory_placode1.55957106
27MP0002102_abnormal_ear_morphology1.50777952
28MP0004215_abnormal_myocardial_fiber1.44182093
29MP0008057_abnormal_DNA_replication1.41534249
30MP0003045_fibrosis1.35409255
31MP0008007_abnormal_cellular_replicative1.35232665
32MP0001529_abnormal_vocalization1.35083318
33MP0005671_abnormal_response_to1.33819485
34MP0002837_dystrophic_cardiac_calcinosis1.33763733
35MP0010030_abnormal_orbit_morphology1.28426811
36MP0010094_abnormal_chromosome_stability1.26539020
37MP0005332_abnormal_amino_acid1.25681857
38MP0005248_abnormal_Harderian_gland1.21548488
39MP0001346_abnormal_lacrimal_gland1.20925856
40MP0004742_abnormal_vestibular_system1.19212362
41MP0000516_abnormal_urinary_system1.19097425
42MP0005367_renal/urinary_system_phenotyp1.19097425
43MP0009697_abnormal_copulation1.18398451
44MP0003941_abnormal_skin_development1.16877795
45MP0000470_abnormal_stomach_morphology1.16237665
46MP0001835_abnormal_antigen_presentation1.15971041
47MP0003937_abnormal_limbs/digits/tail_de1.14545377
48MP0002822_catalepsy1.14160170
49MP0005584_abnormal_enzyme/coenzyme_acti1.10391364
50MP0006036_abnormal_mitochondrial_physio1.09441881
51MP0008873_increased_physiological_sensi1.08610710
52MP0002075_abnormal_coat/hair_pigmentati1.06818104
53MP0003137_abnormal_impulse_conducting1.06681480
54MP0005395_other_phenotype1.04801261
55MP0002736_abnormal_nociception_after1.00772068
56MP0001905_abnormal_dopamine_level0.96885649
57MP0002184_abnormal_innervation0.95574154
58MP0004043_abnormal_pH_regulation0.89884738
59MP0001324_abnormal_eye_pigmentation0.89363383
60MP0000631_abnormal_neuroendocrine_gland0.89356867
61MP0004957_abnormal_blastocyst_morpholog0.88781276
62MP0002572_abnormal_emotion/affect_behav0.87993125
63MP0002876_abnormal_thyroid_physiology0.87147573
64MP0000358_abnormal_cell_content/0.86983778
65MP0003943_abnormal_hepatobiliary_system0.86037473
66MP0002160_abnormal_reproductive_system0.85475052
67MP0000371_diluted_coat_color0.84791732
68MP0009764_decreased_sensitivity_to0.84445447
69MP0001186_pigmentation_phenotype0.83248361
70MP0001727_abnormal_embryo_implantation0.81619028
71MP0005195_abnormal_posterior_eye0.81346406
72MP0005187_abnormal_penis_morphology0.81345694
73MP0002751_abnormal_autonomic_nervous0.79552416
74MP0003567_abnormal_fetal_cardiomyocyte0.79270844
75MP0001486_abnormal_startle_reflex0.78426731
76MP0002138_abnormal_hepatobiliary_system0.78236000
77MP0002067_abnormal_sensory_capabilities0.77229200
78MP0005389_reproductive_system_phenotype0.76269065
79MP0001666_abnormal_nutrient_absorption0.75572810
80MP0003646_muscle_fatigue0.75568968
81MP0003136_yellow_coat_color0.75371493
82MP0004133_heterotaxia0.75325924
83MP0008872_abnormal_physiological_respon0.75190219
84MP0006035_abnormal_mitochondrial_morpho0.75169708
85MP0005636_abnormal_mineral_homeostasis0.73417209
86MP0001968_abnormal_touch/_nociception0.72664842
87MP0005410_abnormal_fertilization0.71715898
88MP0002095_abnormal_skin_pigmentation0.71298073
89MP0004885_abnormal_endolymph0.68897680
90MP0001485_abnormal_pinna_reflex0.67406160
91MP0002168_other_aberrant_phenotype0.67024981
92MP0000647_abnormal_sebaceous_gland0.66521542
93MP0009785_altered_susceptibility_to0.65226567
94MP0003698_abnormal_male_reproductive0.64440842
95MP0002733_abnormal_thermal_nociception0.63934727
96MP0003186_abnormal_redox_activity0.63565697
97MP0000639_abnormal_adrenal_gland0.62958580
98MP0005503_abnormal_tendon_morphology0.62192366
99MP0001970_abnormal_pain_threshold0.61706603
100MP0005084_abnormal_gallbladder_morpholo0.61296685

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.89302416
2Hypoplasia of the fovea (HP:0007750)6.45390335
3Aplasia/Hypoplasia of the fovea (HP:0008060)6.45390335
4Abnormal rod and cone electroretinograms (HP:0008323)6.13092393
5Severe visual impairment (HP:0001141)5.45384145
6Abnormality of the fovea (HP:0000493)5.20080240
7Central scotoma (HP:0000603)5.11070601
8Reduced antithrombin III activity (HP:0001976)4.60042252
9Abnormality of macular pigmentation (HP:0008002)4.48398243
10Aplasia/Hypoplasia of the macula (HP:0008059)4.40099348
11Albinism (HP:0001022)4.20675935
12Type I transferrin isoform profile (HP:0003642)4.12805011
13Aplasia/Hypoplasia affecting the retina (HP:0008061)4.04290957
14Abnormality of DNA repair (HP:0003254)3.92354097
15Molar tooth sign on MRI (HP:0002419)3.58121652
16Abnormality of midbrain morphology (HP:0002418)3.58121652
17Hypoproteinemia (HP:0003075)3.46750444
18Pancreatic cysts (HP:0001737)3.32471434
19Hypoplasia of the pons (HP:0012110)3.30194435
20Abnormality of the pons (HP:0007361)3.17455191
21Scotoma (HP:0000575)3.03449856
22Absent rod-and cone-mediated responses on ERG (HP:0007688)3.00377444
23Nephronophthisis (HP:0000090)2.88229502
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.80027036
25Abnormality of alanine metabolism (HP:0010916)2.80027036
26Hyperalaninemia (HP:0003348)2.80027036
27Gastrointestinal atresia (HP:0002589)2.78307645
28Hypochromic microcytic anemia (HP:0004840)2.77048633
29Abnormal protein glycosylation (HP:0012346)2.75730628
30Abnormal glycosylation (HP:0012345)2.75730628
31Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.75730628
32Abnormal protein N-linked glycosylation (HP:0012347)2.75730628
33Esophageal atresia (HP:0002032)2.73554579
34Bifid tongue (HP:0010297)2.70969905
35Pheochromocytoma (HP:0002666)2.61917743
36Acute lymphatic leukemia (HP:0006721)2.60916970
37Methylmalonic acidemia (HP:0002912)2.60460034
38Abnormality of the renal cortex (HP:0011035)2.57083218
39Inability to walk (HP:0002540)2.51909179
40Abnormality of homocysteine metabolism (HP:0010919)2.49200115
41Homocystinuria (HP:0002156)2.49200115
42Median cleft lip (HP:0000161)2.48946544
43Intestinal atresia (HP:0011100)2.45178524
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.43298748
45Renal cortical cysts (HP:0000803)2.42198267
46Abnormality of the renal medulla (HP:0100957)2.41913354
47Cerebral hemorrhage (HP:0001342)2.38712254
48Aplasia/Hypoplasia of the tibia (HP:0005772)2.37219001
49Capillary hemangiomas (HP:0005306)2.34915570
50Abnormality of chromosome stability (HP:0003220)2.31035548
51Poor head control (HP:0002421)2.24090028
52Decreased central vision (HP:0007663)2.21450502
53Meckel diverticulum (HP:0002245)2.13388269
54Clubbing of toes (HP:0100760)2.10505349
55Colon cancer (HP:0003003)2.09667840
56Neuroendocrine neoplasm (HP:0100634)2.09337863
57Abnormality of the ileum (HP:0001549)2.07832302
58Triphalangeal thumb (HP:0001199)2.05980234
59Constricted visual fields (HP:0001133)2.03421681
60Macular degeneration (HP:0000608)2.02751992
61Hypoglycemic coma (HP:0001325)2.01914883
62Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.99785786
63Attenuation of retinal blood vessels (HP:0007843)1.98690193
64Proximal tubulopathy (HP:0000114)1.97985893
65Tubular atrophy (HP:0000092)1.97586382
66Generalized hypopigmentation (HP:0007513)1.93984328
67Poor coordination (HP:0002370)1.93639032
68Pancreatic fibrosis (HP:0100732)1.93625775
69Abnormal lung lobation (HP:0002101)1.93065770
70Short tibia (HP:0005736)1.91645442
71Progressive inability to walk (HP:0002505)1.84245637
72Abnormality of the prostate (HP:0008775)1.83043131
73Oligomenorrhea (HP:0000876)1.82768907
74Chromosomal breakage induced by crosslinking agents (HP:0003221)1.82519900
75Pancreatic islet-cell hyperplasia (HP:0004510)1.78890773
76Astigmatism (HP:0000483)1.77389130
77True hermaphroditism (HP:0010459)1.75740506
78Abnormal biliary tract morphology (HP:0012440)1.75725401
79Stomatitis (HP:0010280)1.75159680
80Abnormality of the preputium (HP:0100587)1.73177749
81Prolonged QT interval (HP:0001657)1.72298343
82Abnormality of male internal genitalia (HP:0000022)1.71916277
83Methylmalonic aciduria (HP:0012120)1.69670055
84Rib fusion (HP:0000902)1.68312751
85Oligohydramnios (HP:0001562)1.68216973
86Neonatal death (HP:0003811)1.67947403
87Chromsome breakage (HP:0040012)1.66034534
88Mutism (HP:0002300)1.64184195
89Abolished electroretinogram (ERG) (HP:0000550)1.63921069
90Small hand (HP:0200055)1.63330704
91Ectopic kidney (HP:0000086)1.62881454
92Aplasia/Hypoplasia of the tongue (HP:0010295)1.62076257
93Generalized aminoaciduria (HP:0002909)1.61964134
94Absent thumb (HP:0009777)1.61172979
95Abnormality of the vitamin B12 metabolism (HP:0004341)1.60415101
96Oculomotor apraxia (HP:0000657)1.59905976
97Abnormality of the duodenum (HP:0002246)1.59669302
98Duodenal stenosis (HP:0100867)1.59559769
99Small intestinal stenosis (HP:0012848)1.59559769
100Morphological abnormality of the pyramidal tract (HP:0002062)1.57478513

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.80563452
2EIF2AK33.75284369
3FRK3.74380408
4VRK22.94901904
5ACVR1B2.92524146
6BRD42.34033369
7GRK12.25244891
8NUAK12.18236173
9NEK92.18031827
10BMPR1B2.07278188
11YES12.04869254
12WNK32.03794625
13PLK41.93411752
14ERBB31.83115379
15TRPM71.80204298
16TLK11.65549928
17ZAK1.64787916
18TNIK1.59344406
19CHEK21.47356794
20BCKDK1.47203237
21WEE11.44351112
22BUB11.40003127
23MST41.38357788
24MKNK11.34669210
25STK31.30096375
26VRK11.26839436
27CSNK1A1L1.26355580
28TAF11.25105548
29MAPKAPK51.21607822
30ADRBK21.20128060
31EIF2AK21.19400266
32CASK1.17816371
33TRIM281.16801292
34MAP3K121.16638311
35ATR1.13707515
36PAK31.12476544
37OXSR11.10204941
38TEC1.09189533
39MKNK21.08597838
40OBSCN1.07675625
41MUSK1.05177023
42MAPK131.04935298
43WNK41.00524785
44CDK120.99686133
45STK390.99476676
46CSNK1G30.97180161
47PRKCE0.96049237
48IKBKE0.95592770
49CSNK1G10.91350416
50CSNK1G20.90712074
51BRSK20.89736349
52BMPR20.86481968
53MYLK0.85342487
54SYK0.82155457
55CLK10.78130125
56LYN0.74156449
57DYRK20.72609092
58IKBKB0.71941871
59INSRR0.71825008
60PTK2B0.71180341
61UHMK10.64627293
62PLK30.64432559
63PIK3CG0.64417269
64DAPK20.62351313
65NEK20.61013460
66TIE10.57633922
67MAP4K20.54264606
68CSNK1A10.53898516
69PDGFRB0.53166070
70IGF1R0.51246759
71CAMK10.50560100
72ZAP700.49939863
73CAMK40.49314647
74ATM0.49097992
75FES0.48219403
76TGFBR10.46295209
77EGFR0.44677123
78RPS6KB10.44481588
79PRKACA0.44080335
80CSNK1D0.43947257
81ABL10.43839209
82TAOK30.43708514
83CAMK1G0.43073304
84CDK190.40214800
85PRKG10.39444090
86MAPK100.39191464
87CAMK2A0.39183326
88MAPK70.37452464
89TSSK60.37082868
90MARK30.36773443
91FGR0.36568255
92CDC42BPA0.35293417
93AKT30.34302107
94ITK0.33878419
95ERBB20.33804305
96PRKDC0.33369410
97CAMK1D0.32675999
98CDK10.31576639
99ADRBK10.31308986
100KIT0.30926392

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.72540275
2Protein export_Homo sapiens_hsa030603.21858363
3Vitamin digestion and absorption_Homo sapiens_hsa049772.78567886
4Fanconi anemia pathway_Homo sapiens_hsa034602.52904838
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.50401076
6Homologous recombination_Homo sapiens_hsa034402.43731663
7Type I diabetes mellitus_Homo sapiens_hsa049402.20668230
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.15783541
9Autoimmune thyroid disease_Homo sapiens_hsa053202.01692459
10Allograft rejection_Homo sapiens_hsa053301.99266849
11beta-Alanine metabolism_Homo sapiens_hsa004101.96916432
12Graft-versus-host disease_Homo sapiens_hsa053321.90679079
13Histidine metabolism_Homo sapiens_hsa003401.83219440
14Nucleotide excision repair_Homo sapiens_hsa034201.81789818
15Propanoate metabolism_Homo sapiens_hsa006401.74633630
16Tryptophan metabolism_Homo sapiens_hsa003801.73502880
17RNA degradation_Homo sapiens_hsa030181.72026734
18Sulfur metabolism_Homo sapiens_hsa009201.60558607
19Linoleic acid metabolism_Homo sapiens_hsa005911.59370060
20Proteasome_Homo sapiens_hsa030501.58598101
21Regulation of autophagy_Homo sapiens_hsa041401.56512950
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55494977
23DNA replication_Homo sapiens_hsa030301.52048845
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47434135
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43723310
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41055386
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38865133
28RNA transport_Homo sapiens_hsa030131.38676570
29Basal transcription factors_Homo sapiens_hsa030221.36699864
30Cardiac muscle contraction_Homo sapiens_hsa042601.27609743
31Ether lipid metabolism_Homo sapiens_hsa005651.26107033
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24876002
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24481971
34Staphylococcus aureus infection_Homo sapiens_hsa051501.20452689
35Nitrogen metabolism_Homo sapiens_hsa009101.18255692
36One carbon pool by folate_Homo sapiens_hsa006701.10724321
37N-Glycan biosynthesis_Homo sapiens_hsa005101.07941380
38Renin-angiotensin system_Homo sapiens_hsa046141.07773088
39Steroid biosynthesis_Homo sapiens_hsa001001.07454126
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07153507
41Purine metabolism_Homo sapiens_hsa002301.06506969
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05601924
43Lysine degradation_Homo sapiens_hsa003101.04777670
44Oxidative phosphorylation_Homo sapiens_hsa001901.04321913
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02974630
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02291088
47Phototransduction_Homo sapiens_hsa047441.01424085
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00203992
49GABAergic synapse_Homo sapiens_hsa047270.99742491
50Mismatch repair_Homo sapiens_hsa034300.97497841
51Morphine addiction_Homo sapiens_hsa050320.96793266
52Serotonergic synapse_Homo sapiens_hsa047260.91749527
53Renin secretion_Homo sapiens_hsa049240.89759385
54Viral myocarditis_Homo sapiens_hsa054160.86890462
55Butanoate metabolism_Homo sapiens_hsa006500.82434915
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.81924726
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81517137
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.77734928
59Parkinsons disease_Homo sapiens_hsa050120.76456570
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76416239
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76380889
62Fatty acid elongation_Homo sapiens_hsa000620.76015165
63Spliceosome_Homo sapiens_hsa030400.74894563
64Retinol metabolism_Homo sapiens_hsa008300.73550992
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68230708
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66876381
67Base excision repair_Homo sapiens_hsa034100.66777465
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64660229
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.63725933
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.63648989
71Systemic lupus erythematosus_Homo sapiens_hsa053220.63244648
72Olfactory transduction_Homo sapiens_hsa047400.63203158
73Taste transduction_Homo sapiens_hsa047420.62167797
74Sulfur relay system_Homo sapiens_hsa041220.61436037
75p53 signaling pathway_Homo sapiens_hsa041150.61238083
76Rheumatoid arthritis_Homo sapiens_hsa053230.59503915
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.59188069
78Alzheimers disease_Homo sapiens_hsa050100.59146549
79Calcium signaling pathway_Homo sapiens_hsa040200.57445790
80Oxytocin signaling pathway_Homo sapiens_hsa049210.56164921
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.56122823
82Folate biosynthesis_Homo sapiens_hsa007900.55598212
83Leishmaniasis_Homo sapiens_hsa051400.54404102
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52329601
85Chemical carcinogenesis_Homo sapiens_hsa052040.50896115
86Huntingtons disease_Homo sapiens_hsa050160.47810349
87Antigen processing and presentation_Homo sapiens_hsa046120.46206025
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45925121
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43032984
90Cholinergic synapse_Homo sapiens_hsa047250.42779218
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42730086
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41343719
93Peroxisome_Homo sapiens_hsa041460.41276830
94Fatty acid degradation_Homo sapiens_hsa000710.40058970
95Pyruvate metabolism_Homo sapiens_hsa006200.40038073
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.39786111
97Metabolic pathways_Homo sapiens_hsa011000.39645840
98Sphingolipid metabolism_Homo sapiens_hsa006000.39401819
99Pyrimidine metabolism_Homo sapiens_hsa002400.38890244
100Insulin secretion_Homo sapiens_hsa049110.37411888

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