RNF139

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of interleukin-8 biosynthetic process (GO:0045416)8.29281438
2fusion of sperm to egg plasma membrane (GO:0007342)8.14094668
3positive regulation of lipoprotein lipase activity (GO:0051006)7.86621071
4positive regulation of triglyceride lipase activity (GO:0061365)7.86621071
5leukotriene biosynthetic process (GO:0019370)7.74344053
6sperm motility (GO:0030317)7.55201039
7negative regulation of immunoglobulin mediated immune response (GO:0002890)7.14951090
8negative regulation of B cell mediated immunity (GO:0002713)7.14951090
9cell wall macromolecule metabolic process (GO:0044036)6.94967999
10cell wall macromolecule catabolic process (GO:0016998)6.94967999
11interferon-gamma secretion (GO:0072643)6.89520019
12acrosome assembly (GO:0001675)6.67511662
13regulation of B cell apoptotic process (GO:0002902)6.51030937
14glutathione biosynthetic process (GO:0006750)6.49356269
15negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)6.44281519
16negative regulation of T-helper cell differentiation (GO:0045623)6.44281519
17negative regulation of digestive system process (GO:0060457)6.43259304
18ribosome assembly (GO:0042255)6.34820963
19multicellular organism reproduction (GO:0032504)6.32429706
20sperm-egg recognition (GO:0035036)6.31393551
21plasma membrane fusion (GO:0045026)6.00143045
22regulation of cholesterol homeostasis (GO:2000188)5.96779796
23nonribosomal peptide biosynthetic process (GO:0019184)5.90981988
24regulation of memory T cell differentiation (GO:0043380)5.85185337
25cilium or flagellum-dependent cell motility (GO:0001539)5.84751813
26acrosome reaction (GO:0007340)5.83591900
27positive regulation of fatty acid biosynthetic process (GO:0045723)5.80082071
28positive regulation of triglyceride biosynthetic process (GO:0010867)5.70829173
29cell-cell recognition (GO:0009988)5.64865386
30binding of sperm to zona pellucida (GO:0007339)5.62985237
31negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)5.53978755
32reproduction (GO:0000003)5.48922169
33immunoglobulin mediated immune response (GO:0016064)5.45583290
34response to pheromone (GO:0019236)5.40841274
35positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610815.39469247
36negative regulation of interleukin-2 production (GO:0032703)5.37308922
37regulation of interleukin-8 biosynthetic process (GO:0045414)5.21768047
38transcription from mitochondrial promoter (GO:0006390)5.15821442
39regulation of T-helper 2 cell differentiation (GO:0045628)5.05537810
40negative regulation of type 2 immune response (GO:0002829)5.05088038
41spermatid development (GO:0007286)4.99878114
42negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.96733429
43regulation of cholesterol storage (GO:0010885)4.91720476
44leukotriene metabolic process (GO:0006691)4.88102563
45epithelial cilium movement (GO:0003351)4.86814617
46motile cilium assembly (GO:0044458)4.80206945
47icosanoid biosynthetic process (GO:0046456)4.77994975
48fatty acid derivative biosynthetic process (GO:1901570)4.77994975
49phosphatidylethanolamine metabolic process (GO:0046337)4.77556919
50axonemal dynein complex assembly (GO:0070286)4.67412215
51dicarboxylic acid biosynthetic process (GO:0043650)4.64105832
52positive regulation of triglyceride metabolic process (GO:0090208)4.61529441
53response to food (GO:0032094)4.60279199
54C4-dicarboxylate transport (GO:0015740)4.57449820
55positive regulation of protein import into nucleus, translocation (GO:0033160)4.51299787
56positive regulation of cholesterol efflux (GO:0010875)4.49312136
57T cell apoptotic process (GO:0070231)4.41450465
58histone demethylation (GO:0016577)4.39844412
59NLS-bearing protein import into nucleus (GO:0006607)4.37147737
60positive regulation of receptor biosynthetic process (GO:0010870)4.35574310
61germinal center formation (GO:0002467)4.33896292
62histone lysine demethylation (GO:0070076)4.33182778
63regulation of mitotic spindle organization (GO:0060236)4.25673308
64regulation of triglyceride biosynthetic process (GO:0010866)4.24711819
65positive regulation of toll-like receptor signaling pathway (GO:0034123)4.18060921
66positive regulation of cholesterol transport (GO:0032376)4.16999087
67positive regulation of sterol transport (GO:0032373)4.16999087
68negative regulation of alpha-beta T cell differentiation (GO:0046639)4.14975917
69negative regulation of erythrocyte differentiation (GO:0045647)4.13974387
70negative regulation of lymphocyte apoptotic process (GO:0070229)4.13589740
71gastrulation with mouth forming second (GO:0001702)4.13498178
72organic cation transport (GO:0015695)4.11571123
73single fertilization (GO:0007338)4.10228357
74protein K11-linked deubiquitination (GO:0035871)4.09943424
75positive regulation of B cell differentiation (GO:0045579)4.09112033
76negative regulation of lipid storage (GO:0010888)4.06218259
77positive regulation of keratinocyte differentiation (GO:0045618)3.99767885
78unsaturated fatty acid biosynthetic process (GO:0006636)3.98791716
79ADP metabolic process (GO:0046031)3.97303817
80regulation of germinal center formation (GO:0002634)3.94931399
81protein demethylation (GO:0006482)3.91593282
82protein dealkylation (GO:0008214)3.91593282
83sperm capacitation (GO:0048240)3.89831103
84mammary gland epithelial cell proliferation (GO:0033598)3.88742740
85B cell mediated immunity (GO:0019724)3.88518056
86negative regulation of viral release from host cell (GO:1902187)3.88004947
87peptide biosynthetic process (GO:0043043)3.87658985
88apoptotic cell clearance (GO:0043277)3.83033542
89negative regulation of neurotransmitter secretion (GO:0046929)3.81926573
90fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.80793251
91regulation of cilium movement (GO:0003352)3.79384307
92lymphocyte apoptotic process (GO:0070227)3.79227534
93glutamine family amino acid biosynthetic process (GO:0009084)3.77143886
94cilium movement (GO:0003341)3.76299194
95definitive hemopoiesis (GO:0060216)3.75956683
96piRNA metabolic process (GO:0034587)3.72671874
97negative regulation of Rho protein signal transduction (GO:0035024)3.70941928
98negative regulation of viral transcription (GO:0032897)3.69508067
99male meiosis (GO:0007140)3.66935782
100negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.64776626
101response to muramyl dipeptide (GO:0032495)3.64573785
102cytokine biosynthetic process (GO:0042089)3.62839888
103acylglycerol homeostasis (GO:0055090)3.60255537
104triglyceride homeostasis (GO:0070328)3.60255537
105negative regulation of inclusion body assembly (GO:0090084)3.58775963
106alpha-linolenic acid metabolic process (GO:0036109)3.58613098
107auditory behavior (GO:0031223)3.58185133
108synaptonemal complex organization (GO:0070193)3.53690922
109regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.51492085
110positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.51492085
111negative regulation of NF-kappaB import into nucleus (GO:0042347)3.49594245
112negative regulation of cytokine production involved in immune response (GO:0002719)3.49505667
113regulation of triglyceride metabolic process (GO:0090207)3.48803172
114regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.44397322
115urea cycle (GO:0000050)3.44266887
116urea metabolic process (GO:0019627)3.44266887
117regulation of protein polyubiquitination (GO:1902914)3.41655824
118epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.38667582
119L-amino acid import (GO:0043092)3.36443114
120negative regulation of innate immune response (GO:0045824)3.31253587
121regulation of Rac protein signal transduction (GO:0035020)3.30104967
122synaptonemal complex assembly (GO:0007130)3.29626132
123megakaryocyte development (GO:0035855)3.29151875
124glycerol ether metabolic process (GO:0006662)3.25215803
125fertilization (GO:0009566)3.24641785
126mRNA transcription (GO:0009299)3.24222873
127mRNA transcription from RNA polymerase II promoter (GO:0042789)3.20996607
128spermatogenesis (GO:0007283)3.20760416
129positive regulation of mRNA catabolic process (GO:0061014)3.20300099
130male gamete generation (GO:0048232)3.19211217
131ectoderm development (GO:0007398)3.17954417
132artery development (GO:0060840)3.17846363
133oligosaccharide catabolic process (GO:0009313)3.16167183
134positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.14150734
135regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.14150734
136cellular response to thyroid hormone stimulus (GO:0097067)3.12674149
137response to peptidoglycan (GO:0032494)3.11245766
138AMP metabolic process (GO:0046033)3.10050717
139negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.09510369
140carnitine metabolic process (GO:0009437)3.08366314
141regulation of viral release from host cell (GO:1902186)3.07859095
142nucleoside diphosphate biosynthetic process (GO:0009133)3.06674354
143nitrogen cycle metabolic process (GO:0071941)3.06383623
144phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.05990361
145regulation of macrophage activation (GO:0043030)3.03413825
146regulation of fatty acid biosynthetic process (GO:0042304)3.03119611
147negative regulation of leukocyte apoptotic process (GO:2000107)3.01571827
148positive regulation of fatty acid metabolic process (GO:0045923)3.01113075
149regulation of erythrocyte differentiation (GO:0045646)3.00253887
150estrogen biosynthetic process (GO:0006703)3.00143852
151Arp2/3 complex-mediated actin nucleation (GO:0034314)2.99821939
152regulation of macrophage derived foam cell differentiation (GO:0010743)2.99558563
153linoleic acid metabolic process (GO:0043651)2.96950589
154regulation of B cell receptor signaling pathway (GO:0050855)2.93983642
155embryonic process involved in female pregnancy (GO:0060136)2.88384342
156myotube differentiation (GO:0014902)2.85566536
157regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.85052255
158dosage compensation (GO:0007549)2.83742231
159regulation of mRNA catabolic process (GO:0061013)2.83702281
160regulation of histone H3-K9 methylation (GO:0051570)2.82312899
161regulation of interleukin-2 production (GO:0032663)2.81647338
162RNA stabilization (GO:0043489)2.77443995
163mRNA stabilization (GO:0048255)2.77443995
164positive regulation of cell size (GO:0045793)2.76040092
165regulation of response to interferon-gamma (GO:0060330)2.75861316
166negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.75595407
167smooth muscle tissue development (GO:0048745)2.74399064
168glutathione metabolic process (GO:0006749)2.71649252
169poly(A)+ mRNA export from nucleus (GO:0016973)2.71030800
170regulation of NFAT protein import into nucleus (GO:0051532)2.69358689
171peptidyl-lysine dimethylation (GO:0018027)2.68444783
172phospholipid translocation (GO:0045332)2.67355370
173lipid translocation (GO:0034204)2.67355370
174regulation of oxidative stress-induced neuron death (GO:1903203)2.65846901
175histone H3-K9 demethylation (GO:0033169)2.65212882
176cytoplasmic mRNA processing body assembly (GO:0033962)2.65176134
177Rap protein signal transduction (GO:0032486)2.63635589
178negative regulation of histone methylation (GO:0031061)2.62649073
179icosanoid secretion (GO:0032309)2.62330510
180arachidonic acid secretion (GO:0050482)2.62330510
181negative regulation of oligodendrocyte differentiation (GO:0048715)2.60364332
182Golgi to endosome transport (GO:0006895)2.58132858
183retrograde transport, vesicle recycling within Golgi (GO:0000301)2.54479745
184protein targeting to Golgi (GO:0000042)2.54285920
185TOR signaling (GO:0031929)2.53227827
1863-UTR-mediated mRNA stabilization (GO:0070935)2.52944303
187phosphatidylethanolamine biosynthetic process (GO:0006646)2.51804261
188histone H3 acetylation (GO:0043966)2.51618737
189erythrocyte development (GO:0048821)2.50632600
190entrainment of circadian clock by photoperiod (GO:0043153)2.50447723
191regulation of early endosome to late endosome transport (GO:2000641)2.48990287
192regulation of protein import into nucleus, translocation (GO:0033158)2.48538315
193glutathione derivative biosynthetic process (GO:1901687)2.47408535
194glutathione derivative metabolic process (GO:1901685)2.47408535
195regulation of B cell differentiation (GO:0045577)2.47088076
196regulation of interferon-beta biosynthetic process (GO:0045357)2.45537373
197alanine transport (GO:0032328)2.45394751
198negative regulation of cytokine secretion (GO:0050710)2.44387839
199peptidyl-lysine trimethylation (GO:0018023)2.43307984
200negative regulation of B cell apoptotic process (GO:0002903)10.1209351

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.88480940
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.38734877
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse5.32711963
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.93407165
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.85864280
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.74423357
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.66074193
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.65142784
9* RXR_22158963_ChIP-Seq_LIVER_Mouse3.20676865
10* IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.99887174
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.92768251
12* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.88811262
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.54218052
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.48162436
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.44349969
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.42110725
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.41578456
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.40686562
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.39150153
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35084732
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.33171305
22ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.19532600
23ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.17538538
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.02839641
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.93037060
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87397662
27EZH2_22144423_ChIP-Seq_EOC_Human1.84794955
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.83843371
29MYC_22102868_ChIP-Seq_BL_Human1.82414858
30* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.80910148
31* VDR_24763502_ChIP-Seq_THP-1_Human1.78067364
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77945505
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.77786271
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.75561123
35* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74021749
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.70789394
37TFEB_21752829_ChIP-Seq_HELA_Human1.68926320
38RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.68223265
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.64755968
40STAT1_17558387_ChIP-Seq_HELA_Human1.62024491
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61390256
42EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.58386545
43CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.56983170
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55383082
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54786560
46ZNF274_21170338_ChIP-Seq_K562_Hela1.54351356
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.54266119
48PKCTHETA_26484144_Chip-Seq_BREAST_Human1.53367724
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48754346
50* VDR_21846776_ChIP-Seq_THP-1_Human1.48450339
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46720296
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.46716484
53TAL1_26923725_Chip-Seq_HPCs_Mouse1.45667509
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44726431
55KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43309616
56TCF7_22412390_ChIP-Seq_EML_Mouse1.41213389
57* ELF5_23300383_ChIP-Seq_T47D_Human1.40384938
58SCL_19346495_ChIP-Seq_HPC-7_Human1.39765492
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.38723475
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37884270
61WT1_19549856_ChIP-ChIP_CCG9911_Human1.35105854
62FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31645737
63NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31642558
64GATA1_22025678_ChIP-Seq_K562_Human1.30201903
65EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.29827334
66NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29763182
67FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28446972
68* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28267214
69MYB_26560356_Chip-Seq_TH2_Human1.27851548
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25067683
71* VDR_24787735_ChIP-Seq_THP-1_Human1.24697156
72SPI1_23547873_ChIP-Seq_NB4_Human1.23693955
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23296922
74ELK1_19687146_ChIP-ChIP_HELA_Human1.23196195
75* P53_21459846_ChIP-Seq_SAOS-2_Human1.21199176
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20268875
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19384903
78CBP_20019798_ChIP-Seq_JUKART_Human1.19384903
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17597970
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16301672
81FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.14302415
82GATA1_19941827_ChIP-Seq_MEL86_Mouse1.14279747
83RUNX_20019798_ChIP-Seq_JUKART_Human1.13602704
84SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13586148
85* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13535286
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13438074
87SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12838963
88SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12838963
89SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11728883
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11402036
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11029899
92GATA1_26923725_Chip-Seq_HPCs_Mouse1.10736694
93WDR5_24793694_ChIP-Seq_LNCAP_Human1.10289523
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09382256
95BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09141673
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09081882
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08370400
98TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07264481
99KDM2B_26808549_Chip-Seq_DND41_Human1.07183908
100POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05843776
101TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05588484
102HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05444618
103RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05203279
104KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04520549
105FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.04304967
106* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04265209
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03620100
108CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03433061
109PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02942993
110IRF8_21731497_ChIP-ChIP_J774_Mouse1.01336125
111* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01254750
112KAP1_22055183_ChIP-Seq_ESCs_Mouse1.01228221
113CHD1_26751641_Chip-Seq_LNCaP_Human1.00903871
114PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00146537
115CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99611747
116* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99375849
117PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99172043
118GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99085736
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98888150
120SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98871894
121* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98783548
122* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98783548
123GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97979677
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.97811301
125KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97676667
126* ATF3_27146783_Chip-Seq_COLON_Human0.97058987
127SOX2_22085726_ChIP-Seq_NPCs_Mouse0.96958075
128* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96795668
129* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.96406443
130SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95854939
131DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95207543
132PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94909999
133SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94871966
134GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94794786
135ERG_20517297_ChIP-Seq_VCAP_Human0.94013479
136FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93897967
137KDM2B_26808549_Chip-Seq_REH_Human0.93749477
138* MAF_26560356_Chip-Seq_TH1_Human0.93419463
139CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93172881
140VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92987747
141MYB_26560356_Chip-Seq_TH1_Human0.92789700
142AR_20517297_ChIP-Seq_VCAP_Human0.92388768
143HNFA_21074721_ChIP-Seq_CACO-2_Human0.91836416
144EZH2_27294783_Chip-Seq_NPCs_Mouse0.90797565
145SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90731792
146CLOCK_20551151_ChIP-Seq_293T_Human0.90644202
147TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90600576
148SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90565431
149NFYB_21822215_ChIP-Seq_K562_Human0.89563848
150PU_27001747_Chip-Seq_BMDM_Mouse0.88110664
151* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86351540
152FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.85588595
153SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.85528616
154FLI1_21867929_ChIP-Seq_TH2_Mouse0.85347879
155CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85142643
156GATA3_21867929_ChIP-Seq_CD8_Mouse0.84838766
157CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.84656201
158GATA3_24758297_ChIP-Seq_MCF-7_Human0.83665195
159CRX_20693478_ChIP-Seq_RETINA_Mouse0.83641104
160* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.83267130
161SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83074227
162CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81866775
163* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.81664864
164NFE2_27457419_Chip-Seq_LIVER_Mouse0.81483809
165ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80496842
166MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.79945754
167* GATA3_27048872_Chip-Seq_THYMUS_Human0.79831220
168PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.79656110
169GATA3_26560356_Chip-Seq_TH2_Human0.79387626
170MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.78978555
171FOXM1_26456572_ChIP-Seq_MCF-7_Human0.77886658
172ER_23166858_ChIP-Seq_MCF-7_Human0.75745058

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003191_abnormal_cellular_cholesterol6.84865519
2MP0005410_abnormal_fertilization6.67774408
3MP0005365_abnormal_bile_salt4.43800200
4MP0002009_preneoplasia4.21054014
5MP0008995_early_reproductive_senescence4.12149627
6MP0003329_amyloid_beta_deposits3.69029546
7MP0004264_abnormal_extraembryonic_tissu3.63985403
8MP0005360_urolithiasis3.07385207
9MP0001853_heart_inflammation2.81683958
10MP0003943_abnormal_hepatobiliary_system2.80141148
11MP0000604_amyloidosis2.75672382
12MP0003698_abnormal_male_reproductive2.40679718
13MP0002166_altered_tumor_susceptibility2.40406135
14MP0003806_abnormal_nucleotide_metabolis2.39713493
15MP0005647_abnormal_sex_gland2.25354657
16MP0008875_abnormal_xenobiotic_pharmacok2.19363599
17MP0001929_abnormal_gametogenesis2.18280477
18MP0000685_abnormal_immune_system2.15202494
19MP0005085_abnormal_gallbladder_physiolo2.12354047
20MP0003763_abnormal_thymus_physiology2.03608640
21MP0003828_pulmonary_edema2.00033087
22MP0002139_abnormal_hepatobiliary_system11.7007179
23MP0008057_abnormal_DNA_replication1.98667486
24MP0010329_abnormal_lipoprotein_level1.94140041
25MP0010307_abnormal_tumor_latency1.93689752
26MP0002396_abnormal_hematopoietic_system1.88585386
27MP0003183_abnormal_peptide_metabolism1.85307471
28MP0004233_abnormal_muscle_weight1.84776528
29MP0002332_abnormal_exercise_endurance1.82143165
30MP0003303_peritoneal_inflammation1.77066936
31MP0005319_abnormal_enzyme/_coenzyme1.63353385
32MP0003656_abnormal_erythrocyte_physiolo1.62306358
33MP0002006_tumorigenesis1.56586472
34MP0003252_abnormal_bile_duct1.53817665
35MP0000609_abnormal_liver_physiology1.48339445
36MP0004145_abnormal_muscle_electrophysio1.45053787
37MP0004185_abnormal_adipocyte_glucose1.42445908
38MP0003786_premature_aging1.40606032
39MP0000427_abnormal_hair_cycle1.38709893
40MP0001851_eye_inflammation1.31329867
41MP0009840_abnormal_foam_cell1.30320027
42MP0002277_abnormal_respiratory_mucosa1.30202255
43MP0004134_abnormal_chest_morphology1.28794202
44MP0005332_abnormal_amino_acid1.26661268
45MP0002161_abnormal_fertility/fecundity1.21882251
46MP0008469_abnormal_protein_level1.21824975
47MP0003221_abnormal_cardiomyocyte_apopto1.20200423
48MP0000613_abnormal_salivary_gland1.15125603
49MP0002168_other_aberrant_phenotype1.13909594
50MP0010678_abnormal_skin_adnexa1.13813886
51MP0004947_skin_inflammation1.13512791
52MP0005310_abnormal_salivary_gland1.12057768
53MP0005645_abnormal_hypothalamus_physiol1.11863022
54MP0002148_abnormal_hypersensitivity_rea1.11659549
55MP0000383_abnormal_hair_follicle1.11137302
56MP0009278_abnormal_bone_marrow1.08810005
57MP0004484_altered_response_of1.07431718
58MP0005167_abnormal_blood-brain_barrier1.07378857
59MP0003045_fibrosis1.07321577
60MP0001919_abnormal_reproductive_system1.07091459
61MP0005334_abnormal_fat_pad1.06944515
62MP0005670_abnormal_white_adipose1.06323015
63MP0005636_abnormal_mineral_homeostasis1.05545625
64MP0002138_abnormal_hepatobiliary_system1.03622142
65MP0002722_abnormal_immune_system1.03412522
66MP0002796_impaired_skin_barrier1.03241750
67MP0001873_stomach_inflammation1.02750590
68MP0002118_abnormal_lipid_homeostasis1.02215013
69MP0005076_abnormal_cell_differentiation1.00668320
70MP0002210_abnormal_sex_determination1.00171488
71MP0005220_abnormal_exocrine_pancreas0.98332448
72MP0002928_abnormal_bile_duct0.95801454
73MP0001529_abnormal_vocalization0.95340455
74MP0005666_abnormal_adipose_tissue0.95327095
75MP0003633_abnormal_nervous_system0.94505971
76MP0010094_abnormal_chromosome_stability0.94370899
77MP0000716_abnormal_immune_system0.94329363
78MP0005075_abnormal_melanosome_morpholog0.94040936
79MP0009697_abnormal_copulation0.93763357
80MP0009384_cardiac_valve_regurgitation0.93379822
81MP0002098_abnormal_vibrissa_morphology0.93128733
82MP0000371_diluted_coat_color0.92919113
83MP0003195_calcinosis0.92822693
84MP0005535_abnormal_body_temperature0.92424127
85MP0006054_spinal_hemorrhage0.91991652
86MP0000703_abnormal_thymus_morphology0.91779469
87MP0009931_abnormal_skin_appearance0.91610498
88MP0003631_nervous_system_phenotype0.90282578
89MP0003646_muscle_fatigue0.89482560
90MP0003453_abnormal_keratinocyte_physiol0.88992998
91MP0002089_abnormal_postnatal_growth/wei0.88594803
92MP0001764_abnormal_homeostasis0.88416240
93MP0005025_abnormal_response_to0.88372592
94MP0005387_immune_system_phenotype0.86974331
95MP0001790_abnormal_immune_system0.86974331
96MP0002877_abnormal_melanocyte_morpholog0.85980734
97MP0001145_abnormal_male_reproductive0.85340970
98MP0008877_abnormal_DNA_methylation0.85100207
99MP0010234_abnormal_vibrissa_follicle0.83196237
100MP0000350_abnormal_cell_proliferation0.83178628
101MP0000653_abnormal_sex_gland0.81377399
102MP0003632_abnormal_nervous_system0.80219381
103MP0004883_abnormal_blood_vessel0.79727709
104MP0005451_abnormal_body_composition0.78610954
105MP0004782_abnormal_surfactant_physiolog0.77956714
106MP0000747_muscle_weakness0.77552125
107MP0009379_abnormal_foot_pigmentation0.76656198
108MP0002429_abnormal_blood_cell0.76526678
109MP0009763_increased_sensitivity_to0.75935747
110MP0001881_abnormal_mammary_gland0.75725328
111MP0006036_abnormal_mitochondrial_physio0.75641767
112MP0005375_adipose_tissue_phenotype0.75033119
113MP0000569_abnormal_digit_pigmentation0.74757432
114MP0005584_abnormal_enzyme/coenzyme_acti0.73654090
115MP0001800_abnormal_humoral_immune0.73258371
116MP0000470_abnormal_stomach_morphology0.73169494
117MP0000627_abnormal_mammary_gland0.71791508
118MP0000598_abnormal_liver_morphology0.71272642
119MP0003186_abnormal_redox_activity0.70078372
120MP0005164_abnormal_response_to0.69993937
121MP0003959_abnormal_lean_body0.69495918
122MP0009333_abnormal_splenocyte_physiolog0.68613569
123MP0005671_abnormal_response_to0.68165923
124MP0001879_abnormal_lymphatic_vessel0.67818971
125MP0002723_abnormal_immune_serum0.67652210
126MP0008961_abnormal_basal_metabolism0.67623820
127MP0004147_increased_porphyrin_level0.66363961
128MP0005464_abnormal_platelet_physiology0.65536197
129MP0000465_gastrointestinal_hemorrhage0.64716401
130MP0009785_altered_susceptibility_to0.63897405
131MP0000249_abnormal_blood_vessel0.63751640
132MP0001835_abnormal_antigen_presentation0.62741176
133MP0001666_abnormal_nutrient_absorption0.62342447
134MP0002405_respiratory_system_inflammati0.61973260
135MP0001845_abnormal_inflammatory_respons0.61767762
136MP0003724_increased_susceptibility_to0.60663440
137MP0000689_abnormal_spleen_morphology0.58810522
138MP0002133_abnormal_respiratory_system0.58332910
139MP0005388_respiratory_system_phenotype0.58332910
140MP0001765_abnormal_ion_homeostasis0.55746478
141MP0000920_abnormal_myelination0.55522383
142MP0009642_abnormal_blood_homeostasis0.55287025
143MP0000749_muscle_degeneration0.55210824
144MP0003868_abnormal_feces_composition0.54167039
145MP0004019_abnormal_vitamin_homeostasis0.52950761
146MP0005397_hematopoietic_system_phenotyp0.52820219
147MP0001545_abnormal_hematopoietic_system0.52820219
148MP0003950_abnormal_plasma_membrane0.52659201
149MP0002452_abnormal_antigen_presenting0.52639606
150MP0003436_decreased_susceptibility_to0.52338964
151MP0009643_abnormal_urine_homeostasis0.51892242
152MP0002398_abnormal_bone_marrow0.50631425
153MP0003011_delayed_dark_adaptation0.49689014
154MP0005058_abnormal_lysosome_morphology0.48516984
155MP0005083_abnormal_biliary_tract0.48044836
156MP0002420_abnormal_adaptive_immunity0.45934042
157MP0001819_abnormal_immune_cell0.45239676
158MP0002419_abnormal_innate_immunity0.45127386
159MP0001986_abnormal_taste_sensitivity0.43255618
160MP0003705_abnormal_hypodermis_morpholog0.42140839
161MP0003075_altered_response_to0.41286836
162MP0004808_abnormal_hematopoietic_stem0.41255548
163MP0002269_muscular_atrophy0.39375892
164MP0009764_decreased_sensitivity_to0.38484986
165MP0010630_abnormal_cardiac_muscle0.37559505
166MP0005000_abnormal_immune_tolerance0.36042594
167MP0004270_analgesia0.35986475
168MP0004130_abnormal_muscle_cell0.35953030
169MP0002971_abnormal_brown_adipose0.35948227
170MP0003300_gastrointestinal_ulcer0.35481872

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.59398298
2Absent/shortened dynein arms (HP:0200106)7.20817964
3Dynein arm defect of respiratory motile cilia (HP:0012255)7.20817964
4Parakeratosis (HP:0001036)6.14176349
5Abnormality of placental membranes (HP:0011409)5.38036129
6Amniotic constriction ring (HP:0009775)5.38036129
7Homocystinuria (HP:0002156)5.06249581
8Abnormality of homocysteine metabolism (HP:0010919)5.06249581
9Nasal polyposis (HP:0100582)4.67439050
10Abnormal respiratory motile cilium physiology (HP:0012261)4.51138870
11Abnormal respiratory motile cilium morphology (HP:0005938)4.49273317
12Abnormal respiratory epithelium morphology (HP:0012253)4.49273317
13Infertility (HP:0000789)4.47721806
14Chronic bronchitis (HP:0004469)4.32642460
15Hemiparesis (HP:0001269)4.24004721
16Gonadotropin excess (HP:0000837)4.06097089
17Abnormality of the nasal mucosa (HP:0000433)3.99950263
18Rhinitis (HP:0012384)3.98391440
19Microglossia (HP:0000171)3.94838818
20Hemiplegia (HP:0002301)3.90362678
21Abnormality of macular pigmentation (HP:0008002)3.75911604
22Abnormality of the peritoneum (HP:0002585)3.63304302
23Nonprogressive disorder (HP:0003680)3.61650384
24Papillary thyroid carcinoma (HP:0002895)3.50658893
25Abnormal spermatogenesis (HP:0008669)3.50201717
26Peripheral hypomyelination (HP:0007182)3.49931065
27Stomatitis (HP:0010280)3.46650328
28Complement deficiency (HP:0004431)3.46339505
29Pustule (HP:0200039)3.46187044
30Central scotoma (HP:0000603)3.45627662
31Bronchitis (HP:0012387)3.41731912
32Abnormality of the aortic arch (HP:0012303)3.37582305
33Thoracic kyphosis (HP:0002942)3.32646062
34Relative macrocephaly (HP:0004482)3.28020969
35Type 2 muscle fiber atrophy (HP:0003554)3.23285735
36Azoospermia (HP:0000027)3.22467076
37Mediastinal lymphadenopathy (HP:0100721)3.20150173
38Meningioma (HP:0002858)3.19800855
39J-shaped sella turcica (HP:0002680)3.16450903
40Abnormal ciliary motility (HP:0012262)3.05290932
41Abnormality of aromatic amino acid family metabolism (HP:0004338)3.04899289
42Pheochromocytoma (HP:0002666)3.02089801
43Deep venous thrombosis (HP:0002625)3.00486282
44Midline defect of the nose (HP:0004122)2.99398380
45Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.98304827
46Germ cell neoplasia (HP:0100728)2.97516125
47Alveolar cell carcinoma (HP:0006519)2.94123860
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.93728952
49Acute lymphatic leukemia (HP:0006721)2.91100591
50Metaphyseal dysplasia (HP:0100255)2.90573261
51Breast carcinoma (HP:0003002)2.86472455
52Megaloblastic anemia (HP:0001889)2.85197714
53Xanthomatosis (HP:0000991)2.82873534
54Severe combined immunodeficiency (HP:0004430)2.82794834
55Abnormality of the neuromuscular junction (HP:0003398)2.82687972
56Fatigable weakness (HP:0003473)2.82687972
57Diastasis recti (HP:0001540)2.82137815
58Recurrent bronchitis (HP:0002837)2.81124881
59Neoplasm of the tracheobronchial system (HP:0100552)2.79738687
60Abnormality of the thoracic spine (HP:0100711)2.79242651
61Muscle fiber atrophy (HP:0100295)2.77224379
62Macroorchidism (HP:0000053)2.74606289
63Prolonged partial thromboplastin time (HP:0003645)2.73743266
64Acanthocytosis (HP:0001927)2.71406573
65Systemic lupus erythematosus (HP:0002725)2.69116451
66Weak cry (HP:0001612)2.66931233
67Recurrent sinusitis (HP:0011108)2.65654106
68Hypercholesterolemia (HP:0003124)2.65491059
69Abnormality of monocarboxylic acid metabolism (HP:0010996)2.64998786
70Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.64548301
71Glomerulonephritis (HP:0000099)2.64012677
72Hypobetalipoproteinemia (HP:0003563)2.62600863
73Abnormality of the common coagulation pathway (HP:0010990)2.60453354
74Bronchiectasis (HP:0002110)2.59023440
75Male infertility (HP:0003251)2.56765523
76Intrahepatic cholestasis (HP:0001406)2.53697145
77Increased cerebral lipofuscin (HP:0011813)2.51997783
78Abnormality of complement system (HP:0005339)2.51401261
79Recurrent gram-negative bacterial infections (HP:0005420)2.50814165
80Abnormality of fatty-acid metabolism (HP:0004359)2.50640611
81Flat acetabular roof (HP:0003180)2.49246799
82Thyroid carcinoma (HP:0002890)2.49183129
83Abnormality of the lumbar spine (HP:0100712)2.48291448
84Humeroradial synostosis (HP:0003041)2.48101700
85Synostosis involving the elbow (HP:0003938)2.48101700
86Combined immunodeficiency (HP:0005387)2.47232425
87Acute myeloid leukemia (HP:0004808)2.47060330
88Visual hallucinations (HP:0002367)2.45495830
89Abnormality of the intrinsic pathway (HP:0010989)2.45174792
90Neuroendocrine neoplasm (HP:0100634)2.45153486
91Thoracolumbar scoliosis (HP:0002944)2.44185196
92Deformed sella turcica (HP:0002681)2.43698572
93Abnormality of chromosome stability (HP:0003220)2.43521839
94Truncal ataxia (HP:0002078)2.43418642
95Abnormality of iron homeostasis (HP:0011031)2.40706926
96Easy fatigability (HP:0003388)2.40289820
97Pelvic girdle muscle weakness (HP:0003749)2.38469820
98Gonadal dysgenesis (HP:0000133)2.37294229
99Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.37079280
100Overgrowth (HP:0001548)2.35491249
101Curly hair (HP:0002212)2.34978432
102Broad alveolar ridges (HP:0000187)2.34638275
103Vascular calcification (HP:0004934)2.34298843
104Hyperlipoproteinemia (HP:0010980)2.33783412
105Episodic fever (HP:0001954)2.33178864
106Aplasia/Hypoplasia of the clavicles (HP:0006710)2.33014192
107Cone-rod dystrophy (HP:0000548)2.32992118
108Abnormality of the preputium (HP:0100587)2.31792885
109Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.30796456
110Vertebral arch anomaly (HP:0008438)2.30185897
111Septate vagina (HP:0001153)2.29661556
112Abnormal gallbladder physiology (HP:0012438)2.29383765
113Cholecystitis (HP:0001082)2.29383765
114Abnormality of the heme biosynthetic pathway (HP:0010472)2.29366154
115Abnormality of transition element cation homeostasis (HP:0011030)2.29264102
116Insidious onset (HP:0003587)2.25616425
117Termporal pattern (HP:0011008)2.25616425
118Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.22825550
119Broad ribs (HP:0000885)2.21642781
120Abnormality of the vitamin B12 metabolism (HP:0004341)2.20438714
121Poikilocytosis (HP:0004447)2.19876970
122Anteriorly placed anus (HP:0001545)2.19047888
123Carpal bone hypoplasia (HP:0001498)2.18444506
124Clubbing of toes (HP:0100760)2.18237755
125Nephronophthisis (HP:0000090)2.16301408
126Hyperbilirubinemia (HP:0002904)2.15750737
127Hyperglycinuria (HP:0003108)2.15358011
128Abnormality of T cell physiology (HP:0011840)2.14190257
129Dysmetric saccades (HP:0000641)2.13494796
130Acne (HP:0001061)2.13491416
131Cardiovascular calcification (HP:0011915)2.10365517
132Recurrent otitis media (HP:0000403)2.09928100
133Myelodysplasia (HP:0002863)2.09280465
134Joint swelling (HP:0001386)2.07665307
135Tubulointerstitial nephritis (HP:0001970)2.06854782
136Abnormality of liposaccharide metabolism (HP:0010968)2.06744403
137Abnormality of glycosphingolipid metabolism (HP:0004343)2.06744403
138Abnormality of glycolipid metabolism (HP:0010969)2.06744403
139Cubitus valgus (HP:0002967)2.05934371
140Hypolipoproteinemia (HP:0010981)2.05334342
141Microcytic anemia (HP:0001935)2.04679279
142Abnormalities of placenta or umbilical cord (HP:0001194)2.04283321
143Elevated erythrocyte sedimentation rate (HP:0003565)2.03984421
144Amyotrophic lateral sclerosis (HP:0007354)2.03381428
145Epidermoid cyst (HP:0200040)2.03360709
146Reticulocytosis (HP:0001923)2.02247462
147Ketosis (HP:0001946)1.98859827
148Ulnar claw (HP:0001178)1.98798421
149Abnormality of the nasal septum (HP:0000419)1.98581774
150Congenital ichthyosiform erythroderma (HP:0007431)1.96939345
151Meckel diverticulum (HP:0002245)1.96872340
152Abnormality of the hip-girdle musculature (HP:0001445)1.96777221
153Abnormality of the musculature of the pelvis (HP:0001469)1.96777221
154Abnormality of vitamin B metabolism (HP:0004340)1.96027586
155Ankle contracture (HP:0006466)1.95989012
156Abnormality of glycine metabolism (HP:0010895)1.95475892
157Abnormality of serine family amino acid metabolism (HP:0010894)1.95475892
158Urinary urgency (HP:0000012)1.94513089
159Decreased muscle mass (HP:0003199)1.93110399
160Deep philtrum (HP:0002002)1.93034482
161Thickened calvaria (HP:0002684)1.92517627
162Abnormality of the ileum (HP:0001549)1.92132304
163Short clavicles (HP:0000894)1.91672649
164Spinal cord lesions (HP:0100561)1.91473609
165Syringomyelia (HP:0003396)1.91473609
166Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.90676415
167Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90658183
168Exercise-induced muscle cramps (HP:0003710)1.88690305
169Viral hepatitis (HP:0006562)1.88177296
170Fatigue (HP:0012378)1.86171045
171Autoimmune hemolytic anemia (HP:0001890)1.85977074
172Loss of speech (HP:0002371)1.85240515
173Subacute progressive viral hepatitis (HP:0006572)1.84599883
174Hypoalphalipoproteinemia (HP:0003233)1.84432029
175Shoulder girdle muscle weakness (HP:0003547)1.83598422
176Abnormal delayed hypersensitivity skin test (HP:0002963)1.82078903
177Scanning speech (HP:0002168)1.81174208
178Abnormality of the parathyroid morphology (HP:0011766)1.80590108
179Reduced antithrombin III activity (HP:0001976)1.80112702
180Poor coordination (HP:0002370)1.78292750
181Abnormality of methionine metabolism (HP:0010901)1.78024694
182Absent frontal sinuses (HP:0002688)1.77828382
183Myoglobinuria (HP:0002913)1.77524398
184Hamartoma of the eye (HP:0010568)1.76986243
185Nephritis (HP:0000123)1.76971769
186Joint hemorrhage (HP:0005261)1.75349861
187Aplasia/Hypoplasia of the tongue (HP:0010295)1.74671396
188Abnormality of the pleura (HP:0002103)1.72101053
189Frequent falls (HP:0002359)1.71813725
190Menstrual irregularities (HP:0000858)1.71410363
191Micronodular cirrhosis (HP:0001413)1.71252777
192Recurrent viral infections (HP:0004429)1.71015881
193Increased neuronal autofluorescent lipopigment (HP:0002074)1.70776647
194Abnormality of the renal medulla (HP:0100957)1.70693796
195Abnormality of aspartate family amino acid metabolism (HP:0010899)1.69648450
196Limb-girdle muscle atrophy (HP:0003797)1.69293731

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK45.73979842
2PDK35.73979842
3PDK23.39136784
4TSSK63.33871762
5TESK12.88334398
6PRPF4B2.87412577
7EPHA32.86490862
8MAP3K62.83921290
9SCYL22.62944139
10BRD42.49798958
11NTRK32.40777783
12RPS6KB22.36937134
13IKBKB2.12373652
14PRKD32.03952753
15MUSK10.5847382
16BRSK21.85957309
17SIK31.75985662
18ERBB31.68121287
19CDK121.66023718
20ICK1.60618498
21FLT31.55750221
22PKN21.54204034
23BCR1.50904366
24PTK61.46143610
25PTK2B1.41051208
26STK391.34602552
27EIF2AK31.32959498
28MAP4K11.31513977
29MAP3K131.31431141
30CHUK1.30979970
31WNK41.26354612
32MAP2K41.24155208
33TRIM281.20218181
34MAP3K101.19995756
35MAP3K21.19166448
36DYRK1B1.18352641
37BMPR21.16201524
38RPS6KA41.16090342
39FGFR31.15924499
40RET1.14096774
41STK381.11591897
42TYK21.10559564
43MST41.09908579
44MAP3K121.09411078
45FRK1.07617444
46TRPM71.07232476
47TNIK1.05317002
48JAK31.04693086
49PIK3CA1.03026335
50FES1.01823560
51TAF10.95422575
52NEK20.95130133
53STK240.93102926
54IRAK10.91840675
55TBK10.90111671
56FGFR40.89387118
57IRAK30.88456165
58TAOK30.87915749
59MINK10.87325872
60PDK10.84599805
61NLK0.84555156
62BCKDK0.81010027
63CDK90.79393469
64KSR10.77489358
65RPS6KB10.72988185
66YES10.72847540
67MAPK100.70729408
68CSF1R0.70725011
69EIF2AK20.70431878
70MKNK20.70017855
71HCK0.69827958
72OBSCN0.67067412
73ABL10.65977805
74CASK0.64864335
75EPHA20.63365614
76SIK20.61056227
77EIF2AK10.60189158
78TTN0.60077182
79CCNB10.59582838
80AKT30.57172883
81NEK60.56422452
82MAP3K10.56198667
83ABL20.55364622
84EPHB10.54650790
85KIT0.54092866
86NME20.53648582
87TLK10.53016127
88CAMKK20.52082509
89IRAK40.52014251
90ROCK10.51430359
91ERN10.51116679
92CSNK1D0.50340332
93PIK3CG0.49939869
94JAK20.48838512
95CDC70.47147955
96TGFBR20.47142900
97MAP2K30.46409294
98MATK0.46097145
99PRKG20.45602545
100MAPKAPK20.43968439
101RAF10.43780699
102WNK30.43447596
103RPS6KA10.42564077
104LATS10.42487128
105PRKCQ0.41005955
106NEK90.40289336
107RIPK40.40240715
108JAK10.39380495
109GRK60.39274306
110MTOR0.39041856
111PRKG10.38273253
112PIM10.37967049
113EEF2K0.37738951
114MAPK120.36848249
115MAPK80.36845649
116MAPK150.36724926
117WNK10.36531334
118TAOK20.35958727
119VRK10.35710991
120MAPKAPK50.35305290
121MAPK110.35184093
122MAP3K140.34814393
123PRKD10.34747890
124IGF1R0.34286410
125CHEK10.33781289
126ZAP700.32988012
127PIM20.32238563
128MAPK40.32154871
129STK100.31683653
130RPS6KC10.31426484
131RPS6KL10.31426484
132CAMKK10.31337368
133STK110.30986744
134CDK60.30768700
135IKBKE0.30715254
136CSNK1G10.30637663
137TRIB30.30038174
138MET0.29442585
139HIPK20.29213658
140CSK0.28980923
141ACVR1B0.28532519
142BTK0.27843129
143SGK10.27466360
144MAPK30.26439523
145MAP3K80.26432192
146PASK0.25770124
147MAP3K70.25691082
148CSNK2A10.24930726
149TEC0.24613829
150LCK0.24391398
151SYK0.24023736
152MAP3K30.21176756
153DYRK30.20840362
154PDPK10.20487423
155MAP3K110.20195308
156PINK10.19694513
157EGFR0.19496015
158MST1R0.18387126
159MAP2K60.18304250
160MAP3K50.18124353
161SIK10.17388941
162ITK0.15748313
163PDGFRB0.15542228

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.32816397
2PPAR signaling pathway_Homo sapiens_hsa033203.28050996
3Nitrogen metabolism_Homo sapiens_hsa009103.19588446
4Fatty acid degradation_Homo sapiens_hsa000713.01351529
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.97150620
6Complement and coagulation cascades_Homo sapiens_hsa046102.35331075
7Staphylococcus aureus infection_Homo sapiens_hsa051502.27212596
8Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.25734524
9Fatty acid metabolism_Homo sapiens_hsa012122.22973975
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.21476026
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.20767269
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.16649382
13Pyruvate metabolism_Homo sapiens_hsa006202.08524300
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.06625259
15Selenocompound metabolism_Homo sapiens_hsa004501.99320279
16Fatty acid biosynthesis_Homo sapiens_hsa000611.96711378
17ABC transporters_Homo sapiens_hsa020101.93045071
18Chronic myeloid leukemia_Homo sapiens_hsa052201.88546103
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.81815299
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.80586178
21Arginine biosynthesis_Homo sapiens_hsa002201.79893238
22Peroxisome_Homo sapiens_hsa041461.79403670
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.75399394
24Vitamin B6 metabolism_Homo sapiens_hsa007501.74748665
25Hepatitis B_Homo sapiens_hsa051611.73136281
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.72663742
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.71072754
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70879412
29Endometrial cancer_Homo sapiens_hsa052131.70632573
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.69963073
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.67155954
32Acute myeloid leukemia_Homo sapiens_hsa052211.66949909
33Prolactin signaling pathway_Homo sapiens_hsa049171.65626604
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.60791986
35TNF signaling pathway_Homo sapiens_hsa046681.60053650
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.57995066
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.54827769
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.54282829
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.53972604
40Non-small cell lung cancer_Homo sapiens_hsa052231.51820353
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.51339283
42Estrogen signaling pathway_Homo sapiens_hsa049151.51311862
43VEGF signaling pathway_Homo sapiens_hsa043701.50920872
44One carbon pool by folate_Homo sapiens_hsa006701.50842515
45Osteoclast differentiation_Homo sapiens_hsa043801.49723225
46Toll-like receptor signaling pathway_Homo sapiens_hsa046201.47223395
47Carbon metabolism_Homo sapiens_hsa012001.47197540
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.43706083
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43656315
50FoxO signaling pathway_Homo sapiens_hsa040681.41672259
51Prostate cancer_Homo sapiens_hsa052151.41263140
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.40477405
53Tryptophan metabolism_Homo sapiens_hsa003801.39685597
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.36940270
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.35282553
56B cell receptor signaling pathway_Homo sapiens_hsa046621.34163364
57Pancreatic cancer_Homo sapiens_hsa052121.34139512
58Linoleic acid metabolism_Homo sapiens_hsa005911.32920200
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30603053
60Renal cell carcinoma_Homo sapiens_hsa052111.30504372
61Sulfur metabolism_Homo sapiens_hsa009201.30426760
62Pentose phosphate pathway_Homo sapiens_hsa000301.30246897
63Platelet activation_Homo sapiens_hsa046111.28850100
64beta-Alanine metabolism_Homo sapiens_hsa004101.28487540
65Neurotrophin signaling pathway_Homo sapiens_hsa047221.27313745
66Chemical carcinogenesis_Homo sapiens_hsa052041.27259241
67Leishmaniasis_Homo sapiens_hsa051401.26889252
68N-Glycan biosynthesis_Homo sapiens_hsa005101.24432909
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24056855
70Jak-STAT signaling pathway_Homo sapiens_hsa046301.20447498
71Longevity regulating pathway - mammal_Homo sapiens_hsa042111.20228983
72Systemic lupus erythematosus_Homo sapiens_hsa053221.20013102
73Biosynthesis of amino acids_Homo sapiens_hsa012301.19586792
74Sphingolipid signaling pathway_Homo sapiens_hsa040711.18471841
75mTOR signaling pathway_Homo sapiens_hsa041501.17739587
76Glycerolipid metabolism_Homo sapiens_hsa005611.15280418
77Caffeine metabolism_Homo sapiens_hsa002321.15233295
78Bile secretion_Homo sapiens_hsa049761.11068795
79mRNA surveillance pathway_Homo sapiens_hsa030151.11011701
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08292206
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07468000
82Circadian rhythm_Homo sapiens_hsa047101.06431075
83Toxoplasmosis_Homo sapiens_hsa051451.06011603
84Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05443248
85Fat digestion and absorption_Homo sapiens_hsa049751.05320572
86ErbB signaling pathway_Homo sapiens_hsa040121.05285655
87Glycerophospholipid metabolism_Homo sapiens_hsa005641.02846983
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99647627
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98840155
90Steroid biosynthesis_Homo sapiens_hsa001000.98379010
91Fanconi anemia pathway_Homo sapiens_hsa034600.97807841
92Thyroid cancer_Homo sapiens_hsa052160.97584259
93Shigellosis_Homo sapiens_hsa051310.96989435
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96607553
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96320091
96Fatty acid elongation_Homo sapiens_hsa000620.96132485
97Starch and sucrose metabolism_Homo sapiens_hsa005000.94725396
98Retinol metabolism_Homo sapiens_hsa008300.94205193
99Lysosome_Homo sapiens_hsa041420.93895185
100Mineral absorption_Homo sapiens_hsa049780.93504672
101Histidine metabolism_Homo sapiens_hsa003400.91058288
102Chemokine signaling pathway_Homo sapiens_hsa040620.90377713
103Butanoate metabolism_Homo sapiens_hsa006500.89421077
104Colorectal cancer_Homo sapiens_hsa052100.88018317
105Inositol phosphate metabolism_Homo sapiens_hsa005620.86244450
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.85441224
107Glucagon signaling pathway_Homo sapiens_hsa049220.85233813
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84553815
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83679258
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83003775
111Insulin resistance_Homo sapiens_hsa049310.82532491
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.82299738
113Glioma_Homo sapiens_hsa052140.80210403
114Legionellosis_Homo sapiens_hsa051340.78673867
115Sphingolipid metabolism_Homo sapiens_hsa006000.77910117
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74830993
117Vitamin digestion and absorption_Homo sapiens_hsa049770.74818054
118Ether lipid metabolism_Homo sapiens_hsa005650.74764175
119Sulfur relay system_Homo sapiens_hsa041220.73772867
120Renin secretion_Homo sapiens_hsa049240.73420313
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.72636632
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72078983
123Glutathione metabolism_Homo sapiens_hsa004800.69868080
124Base excision repair_Homo sapiens_hsa034100.68595159
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67854789
126Influenza A_Homo sapiens_hsa051640.66157808
127AMPK signaling pathway_Homo sapiens_hsa041520.65723816
128MAPK signaling pathway_Homo sapiens_hsa040100.65439936
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65086284
130Insulin signaling pathway_Homo sapiens_hsa049100.64608669
131p53 signaling pathway_Homo sapiens_hsa041150.64279860
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62976030
133Renin-angiotensin system_Homo sapiens_hsa046140.62081946
134T cell receptor signaling pathway_Homo sapiens_hsa046600.60780009
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60679448
136Cocaine addiction_Homo sapiens_hsa050300.60233570
137Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59158179
138Metabolic pathways_Homo sapiens_hsa011000.58941631
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56800343
140Epstein-Barr virus infection_Homo sapiens_hsa051690.55200340
141Long-term depression_Homo sapiens_hsa047300.54706492
142Pertussis_Homo sapiens_hsa051330.53518939
143MicroRNAs in cancer_Homo sapiens_hsa052060.52927571
144Folate biosynthesis_Homo sapiens_hsa007900.52748761
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52397253
146Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52102643
147Choline metabolism in cancer_Homo sapiens_hsa052310.52063236
148Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50016263
149Proteoglycans in cancer_Homo sapiens_hsa052050.49203899
150Bladder cancer_Homo sapiens_hsa052190.47873513
151Apoptosis_Homo sapiens_hsa042100.46892546
152Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46746588
153HTLV-I infection_Homo sapiens_hsa051660.46434765
154Adipocytokine signaling pathway_Homo sapiens_hsa049200.41846615
155Alcoholism_Homo sapiens_hsa050340.41549753
156Antigen processing and presentation_Homo sapiens_hsa046120.40604486
157Hematopoietic cell lineage_Homo sapiens_hsa046400.39795831
158African trypanosomiasis_Homo sapiens_hsa051430.38825407
159Cell cycle_Homo sapiens_hsa041100.38357503
160Small cell lung cancer_Homo sapiens_hsa052220.38229920
161DNA replication_Homo sapiens_hsa030300.35615509
162Prion diseases_Homo sapiens_hsa050200.35530095
163Viral carcinogenesis_Homo sapiens_hsa052030.34700306
164Purine metabolism_Homo sapiens_hsa002300.34633288
165Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33672147
166Malaria_Homo sapiens_hsa051440.33156785
167Arginine and proline metabolism_Homo sapiens_hsa003300.31964198
168Other glycan degradation_Homo sapiens_hsa005110.31298666
169Hepatitis C_Homo sapiens_hsa051600.31155642
170Tuberculosis_Homo sapiens_hsa051520.28909095
171Maturity onset diabetes of the young_Homo sapiens_hsa049500.28725420
172Dorso-ventral axis formation_Homo sapiens_hsa043200.27388577
173Phenylalanine metabolism_Homo sapiens_hsa003600.25745852
174Tyrosine metabolism_Homo sapiens_hsa003500.25450370
175Measles_Homo sapiens_hsa051620.25397151
176Herpes simplex infection_Homo sapiens_hsa051680.23071070
177Lysine degradation_Homo sapiens_hsa003100.21646409
178Fructose and mannose metabolism_Homo sapiens_hsa000510.19351918

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