RNF14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.74689194
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.70832408
3synaptic vesicle maturation (GO:0016188)5.53954841
4glutamate secretion (GO:0014047)5.50311410
5synaptic vesicle docking involved in exocytosis (GO:0016081)5.48306601
6regulation of synaptic vesicle exocytosis (GO:2000300)5.22054979
7vocalization behavior (GO:0071625)5.20095944
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.01538360
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.00422216
10locomotory exploration behavior (GO:0035641)4.95358804
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.92942569
12regulation of glutamate receptor signaling pathway (GO:1900449)4.66484972
13regulation of synaptic vesicle transport (GO:1902803)4.63330757
14protein localization to synapse (GO:0035418)4.60159359
15neurotransmitter secretion (GO:0007269)4.58427019
16neuron cell-cell adhesion (GO:0007158)4.53302431
17neurotransmitter-gated ion channel clustering (GO:0072578)4.45943554
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.45372950
19exploration behavior (GO:0035640)4.10768534
20neuronal action potential propagation (GO:0019227)4.04630158
21proline transport (GO:0015824)4.02661484
22regulation of synapse structural plasticity (GO:0051823)3.98799528
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.91319594
24gamma-aminobutyric acid transport (GO:0015812)3.90047963
25layer formation in cerebral cortex (GO:0021819)3.89421984
26neuron-neuron synaptic transmission (GO:0007270)3.81280855
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.80876226
28regulation of neuronal synaptic plasticity (GO:0048168)3.80408946
29synaptic transmission, glutamatergic (GO:0035249)3.77749542
30positive regulation of synapse maturation (GO:0090129)3.74632447
31activation of protein kinase A activity (GO:0034199)3.70320666
32regulation of acyl-CoA biosynthetic process (GO:0050812)3.64647937
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.63162107
34neurotransmitter transport (GO:0006836)3.60538681
35negative regulation of synaptic transmission, GABAergic (GO:0032229)3.57436160
36glutamate receptor signaling pathway (GO:0007215)3.57007729
37piRNA metabolic process (GO:0034587)3.51628652
38postsynaptic membrane organization (GO:0001941)3.48196287
39cullin deneddylation (GO:0010388)3.46851745
40positive regulation of membrane potential (GO:0045838)3.46113007
41long-term synaptic potentiation (GO:0060291)3.40303124
42synaptic vesicle endocytosis (GO:0048488)3.39605221
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.39074888
44regulation of neurotransmitter secretion (GO:0046928)3.36508575
45regulation of neurotransmitter levels (GO:0001505)3.34899762
46regulation of protein glycosylation (GO:0060049)3.34569548
47presynaptic membrane assembly (GO:0097105)3.32929859
48long-term memory (GO:0007616)3.29966089
49regulation of synaptic transmission, glutamatergic (GO:0051966)3.28099419
50regulation of cofactor metabolic process (GO:0051193)3.26849684
51regulation of coenzyme metabolic process (GO:0051196)3.26849684
52regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.26695536
53regulation of synaptic plasticity (GO:0048167)3.26493259
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26304652
55positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.25767611
56neuron recognition (GO:0008038)3.25424584
57gamma-aminobutyric acid signaling pathway (GO:0007214)3.25134156
58regulation of postsynaptic membrane potential (GO:0060078)3.24246143
59regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.23939116
60positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.21251106
61positive regulation of synaptic transmission, GABAergic (GO:0032230)3.19493207
62cerebellar Purkinje cell differentiation (GO:0021702)3.18836522
63proteasome assembly (GO:0043248)3.16466401
64inositol phosphate catabolic process (GO:0071545)3.16436668
65positive regulation of neurotransmitter transport (GO:0051590)3.14479950
66phosphorylated carbohydrate dephosphorylation (GO:0046838)3.13870551
67inositol phosphate dephosphorylation (GO:0046855)3.13870551
68protein deneddylation (GO:0000338)3.13666214
69cerebellar granule cell differentiation (GO:0021707)3.12612322
70regulation of neurotransmitter transport (GO:0051588)3.12366462
71cellular potassium ion homeostasis (GO:0030007)3.10955208
72presynaptic membrane organization (GO:0097090)3.08848942
73vesicle transport along microtubule (GO:0047496)3.07945202
74positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.07549256
75negative regulation of dendrite morphogenesis (GO:0050774)3.06288824
76amino acid salvage (GO:0043102)3.06227050
77L-methionine salvage (GO:0071267)3.06227050
78L-methionine biosynthetic process (GO:0071265)3.06227050
79negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04240710
80positive regulation of neurotransmitter secretion (GO:0001956)3.03522205
81L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.02840373
82neuromuscular process controlling posture (GO:0050884)3.01811352
83dendritic spine morphogenesis (GO:0060997)3.01596187
84response to histamine (GO:0034776)3.01231350
85positive regulation of mitochondrial fission (GO:0090141)3.01217408
86regulation of meiosis I (GO:0060631)2.99837632
87regulation of vesicle fusion (GO:0031338)2.99264976
88auditory behavior (GO:0031223)2.98581337
89regulation of sulfur metabolic process (GO:0042762)2.98457446
90ketone body metabolic process (GO:1902224)2.98135597
91cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.97686805
92cell migration in hindbrain (GO:0021535)2.97016120
93positive regulation of synaptic transmission (GO:0050806)2.96812697
94retinal cone cell development (GO:0046549)2.95638628
95behavioral response to cocaine (GO:0048148)2.94219736
96neuromuscular process controlling balance (GO:0050885)2.92637283
97axonal fasciculation (GO:0007413)2.92279860
98magnesium ion transport (GO:0015693)2.92083040
99membrane depolarization during action potential (GO:0086010)2.91701511
100innervation (GO:0060384)2.91033510
101regulation of dendritic spine morphogenesis (GO:0061001)2.90931781
102synaptic transmission (GO:0007268)2.90848475
103response to auditory stimulus (GO:0010996)2.90744088
104establishment of synaptic vesicle localization (GO:0097480)2.90603890
105synaptic vesicle transport (GO:0048489)2.90603890
106dendrite morphogenesis (GO:0048813)2.90378335
107synapse assembly (GO:0007416)2.87192235
108macroautophagy (GO:0016236)2.86522621
109organelle transport along microtubule (GO:0072384)2.86213426
110energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.84644852
111ATP hydrolysis coupled proton transport (GO:0015991)2.84644852
112regulation of synaptic transmission (GO:0050804)2.84466583
113cell communication by electrical coupling (GO:0010644)2.84269510
114negative regulation of dendrite development (GO:2000171)2.83767723
115regulation of synaptic transmission, GABAergic (GO:0032228)2.83556182
116transferrin transport (GO:0033572)2.83366981
117membrane depolarization (GO:0051899)2.83165163
118regulation of synapse maturation (GO:0090128)2.83161377
119nucleotide transmembrane transport (GO:1901679)2.81934559
120establishment of vesicle localization (GO:0051650)2.81231115
121learning (GO:0007612)2.81199332
122sodium ion export (GO:0071436)2.80572925
123detection of calcium ion (GO:0005513)2.80211026
124acrosome assembly (GO:0001675)2.80165176
125cellular ketone body metabolic process (GO:0046950)2.79013968
126regulation of cAMP-dependent protein kinase activity (GO:2000479)2.77941552
127COPII vesicle coating (GO:0048208)2.74324413
128signal peptide processing (GO:0006465)2.71097891
129lipid particle organization (GO:0034389)2.65962833
130dopamine transport (GO:0015872)2.64583382
131acrosome reaction (GO:0007340)2.64165263
132peroxisome fission (GO:0016559)2.62750675
133DNA methylation involved in gamete generation (GO:0043046)2.62201574
134regulation of integrin-mediated signaling pathway (GO:2001044)2.60517522
135positive regulation of glycolytic process (GO:0045821)2.59281580
136peptidyl-cysteine modification (GO:0018198)2.59035646
137isoprenoid biosynthetic process (GO:0008299)2.56874390
138ER to Golgi vesicle-mediated transport (GO:0006888)2.56822871
139ribonucleoprotein complex disassembly (GO:0032988)2.56720069
140melanin biosynthetic process (GO:0042438)2.55550067
141intra-Golgi vesicle-mediated transport (GO:0006891)2.53776509
142protein localization to cilium (GO:0061512)2.50344149
143polyol catabolic process (GO:0046174)2.48983459
144vascular smooth muscle contraction (GO:0014829)2.48409465
145sterol biosynthetic process (GO:0016126)2.46390173
146secondary metabolite biosynthetic process (GO:0044550)2.46311100
147membrane budding (GO:0006900)2.45662783
148branched-chain amino acid catabolic process (GO:0009083)2.44240552
149regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.42609687
150regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.40815682
151calcium ion-dependent exocytosis (GO:0017156)2.39099371
152cholesterol biosynthetic process (GO:0006695)2.37563244
153protein localization to Golgi apparatus (GO:0034067)2.37328794
154response to redox state (GO:0051775)2.37283801
155tricarboxylic acid cycle (GO:0006099)2.36483760
156positive regulation of protein autophosphorylation (GO:0031954)2.35324572
157regulation of acrosome reaction (GO:0060046)2.34324937
158regulation of oxidative phosphorylation (GO:0002082)2.33666750
159righting reflex (GO:0060013)2.32356410
160calcium-mediated signaling using intracellular calcium source (GO:0035584)2.30910478
161positive regulation of actin filament depolymerization (GO:0030836)2.30822585
162xenobiotic catabolic process (GO:0042178)2.29575335
163negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.29261255
164platelet dense granule organization (GO:0060155)2.28453392
165dopamine biosynthetic process (GO:0042416)2.26467445
166protein targeting to Golgi (GO:0000042)2.24428005
167regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.23659727
168Golgi to endosome transport (GO:0006895)2.22586519
169methionine metabolic process (GO:0006555)2.22452045
170establishment of melanosome localization (GO:0032401)2.22314286
171melanosome transport (GO:0032402)2.22128616
172regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.22110718
173methionine biosynthetic process (GO:0009086)2.21730023
174relaxation of smooth muscle (GO:0044557)2.21281657
175water-soluble vitamin biosynthetic process (GO:0042364)2.20849248
176multicellular organism reproduction (GO:0032504)2.19846404
177protein neddylation (GO:0045116)2.19416732
178positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.18929302
179positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.18929302
180positive regulation of mitotic sister chromatid separation (GO:1901970)2.18929302
181anterograde synaptic vesicle transport (GO:0048490)2.18244904
182establishment of pigment granule localization (GO:0051905)2.18082108
183pigment granule transport (GO:0051904)2.17712506
184preassembly of GPI anchor in ER membrane (GO:0016254)2.16570344
185regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.15562373
186anterograde axon cargo transport (GO:0008089)2.15003758
187respiratory chain complex IV assembly (GO:0008535)2.14353539
188cellular response to leptin stimulus (GO:0044320)2.13518316
189fatty acid elongation (GO:0030497)2.13426997
190myelin assembly (GO:0032288)2.12811466
191positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.12369246
192establishment of protein localization to Golgi (GO:0072600)2.11210378
193muscle cell cellular homeostasis (GO:0046716)2.11010562
194succinate metabolic process (GO:0006105)2.10766035

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.28494204
2GBX2_23144817_ChIP-Seq_PC3_Human3.80560877
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03488265
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.99220354
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89848161
6REST_21632747_ChIP-Seq_MESCs_Mouse2.78453309
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71873088
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.71322719
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46312570
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46312570
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44106975
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.44103529
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43493604
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.42371454
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37851436
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.37750975
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36892644
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34944382
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32028645
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.25705661
21DROSHA_22980978_ChIP-Seq_HELA_Human2.22627659
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.14517176
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12847435
24TAF15_26573619_Chip-Seq_HEK293_Human2.02544224
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.02258516
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02242077
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01085815
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.00098683
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99839558
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.99104682
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97318382
32AR_21572438_ChIP-Seq_LNCaP_Human1.96553942
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.94570547
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.90160866
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90022121
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84823492
37SMAD4_21799915_ChIP-Seq_A2780_Human1.80974990
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78548059
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76080238
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74295409
41EWS_26573619_Chip-Seq_HEK293_Human1.71512948
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70581069
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.69145144
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66596982
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.64900829
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.63500974
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60497485
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59803242
49* ELK1_19687146_ChIP-ChIP_HELA_Human1.55336243
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.54156484
51RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.54114992
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53328726
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.52983023
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51768009
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.51421043
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50131435
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.49184939
58P300_19829295_ChIP-Seq_ESCs_Human1.49122575
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46222092
60* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.45851574
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.45213134
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42239842
63CDX2_22108803_ChIP-Seq_LS180_Human1.39058750
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39022494
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38514920
66ZNF274_21170338_ChIP-Seq_K562_Hela1.37085233
67P53_22387025_ChIP-Seq_ESCs_Mouse1.36757901
68AR_25329375_ChIP-Seq_VCAP_Human1.34949106
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.34557224
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.34456665
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34012024
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33748231
73CMYC_18555785_Chip-Seq_ESCs_Mouse1.32746335
74STAT3_23295773_ChIP-Seq_U87_Human1.32727993
75IGF1R_20145208_ChIP-Seq_DFB_Human1.31644604
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30793508
77NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30793508
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.30235467
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29646503
80SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28648747
81STAT3_18555785_Chip-Seq_ESCs_Mouse1.28188239
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.28183186
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28030443
84SOX2_19829295_ChIP-Seq_ESCs_Human1.27318450
85NANOG_19829295_ChIP-Seq_ESCs_Human1.27318450
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.26103083
87FOXM1_26456572_ChIP-Seq_MCF-7_Human1.26080073
88E2F1_18555785_Chip-Seq_ESCs_Mouse1.24450185
89HTT_18923047_ChIP-ChIP_STHdh_Human1.24358361
90POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24314283
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24304038
92RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24011594
93EP300_21415370_ChIP-Seq_HL-1_Mouse1.23727977
94* AR_19668381_ChIP-Seq_PC3_Human1.22078149
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22032252
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22023606
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.20527727
98DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19560737
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18765258
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18066537
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15922840
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15756021
103SOX2_18555785_Chip-Seq_ESCs_Mouse1.14931896
104SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14054187
105PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13895170
106BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13684758
107P300_18555785_Chip-Seq_ESCs_Mouse1.13653016
108EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13330358
109PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13321326
110TCF4_23295773_ChIP-Seq_U87_Human1.12879709
111FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12140643
112TCF4_22108803_ChIP-Seq_LS180_Human1.11241876
113P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11038827
114CJUN_26792858_Chip-Seq_BT549_Human1.10614411
115PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10534850
116PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10345071
117OCT4_18555785_Chip-Seq_ESCs_Mouse1.09569633
118TP53_18474530_ChIP-ChIP_U2OS_Human1.09381586
119ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09246209
120TP53_22573176_ChIP-Seq_HFKS_Human1.09050484
121ARNT_22903824_ChIP-Seq_MCF-7_Human1.08878288
122OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08505595
123CTCF_18555785_Chip-Seq_ESCs_Mouse1.08336193
124EST1_17652178_ChIP-ChIP_JURKAT_Human1.07778934
125YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07583667
126RING1B_27294783_Chip-Seq_ESCs_Mouse1.07417887
127TAL1_26923725_Chip-Seq_HPCs_Mouse1.07329964
128RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06574081
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05751759
130WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03752990
131RNF2_27304074_Chip-Seq_NSC_Mouse1.03503496
132CBX2_27304074_Chip-Seq_ESCs_Mouse1.03251552
133AHR_22903824_ChIP-Seq_MCF-7_Human1.03197948
134CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02500662
135PRDM14_20953172_ChIP-Seq_ESCs_Human1.02440128
136TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99926291
137RUNX2_22187159_ChIP-Seq_PCA_Human0.98569964
138FUS_26573619_Chip-Seq_HEK293_Human0.97692475
139JUN_21703547_ChIP-Seq_K562_Human0.96667445
140SMAD4_21741376_ChIP-Seq_HESCs_Human0.96646946
141ER_23166858_ChIP-Seq_MCF-7_Human0.95535318
142SMAD3_21741376_ChIP-Seq_ESCs_Human0.95351219
143UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94805580
144EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93058660
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92449094
146VDR_22108803_ChIP-Seq_LS180_Human0.92386682
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91566915
148ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89636617
149PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88805917
150* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87358681
151IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87273109
152CBP_20019798_ChIP-Seq_JUKART_Human0.87273109
153FLI1_21867929_ChIP-Seq_TH2_Mouse0.86945546
154CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86554116
155RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86485613
156BCAT_22108803_ChIP-Seq_LS180_Human0.86119373
157CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85595494
158BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84482237

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.03310369
2MP0003880_abnormal_central_pattern4.54291114
3MP0003635_abnormal_synaptic_transmissio4.02993666
4MP0004270_analgesia3.76325639
5MP0002063_abnormal_learning/memory/cond3.28999752
6MP0009745_abnormal_behavioral_response3.27697222
7MP0001968_abnormal_touch/_nociception3.11020543
8MP0009046_muscle_twitch3.10998422
9MP0002064_seizures3.09463534
10MP0000372_irregular_coat_pigmentation3.06556517
11MP0002734_abnormal_mechanical_nocicepti2.85024882
12MP0002572_abnormal_emotion/affect_behav2.76093168
13MP0009780_abnormal_chondrocyte_physiolo2.73359435
14MP0008877_abnormal_DNA_methylation2.70147728
15MP0002102_abnormal_ear_morphology2.68954928
16MP0005171_absent_coat_pigmentation2.66110190
17MP0000015_abnormal_ear_pigmentation2.64410951
18MP0002736_abnormal_nociception_after2.51581316
19MP0002735_abnormal_chemical_nociception2.50146952
20MP0002822_catalepsy2.48386879
21MP0002272_abnormal_nervous_system2.47759042
22MP0004147_increased_porphyrin_level2.38181111
23MP0005423_abnormal_somatic_nervous2.31230124
24MP0001486_abnormal_startle_reflex2.27308048
25MP0005408_hypopigmentation2.19466984
26MP0002733_abnormal_thermal_nociception2.12956896
27MP0002909_abnormal_adrenal_gland2.07344070
28MP0001501_abnormal_sleep_pattern2.05628063
29MP0001970_abnormal_pain_threshold2.02955076
30MP0004084_abnormal_cardiac_muscle2.00835354
31MP0001440_abnormal_grooming_behavior1.99216732
32MP0002067_abnormal_sensory_capabilities1.98556935
33MP0006054_spinal_hemorrhage1.92743255
34MP0005646_abnormal_pituitary_gland1.91656292
35MP0006276_abnormal_autonomic_nervous1.90534392
36MP0005085_abnormal_gallbladder_physiolo1.88045281
37MP0003195_calcinosis1.87877804
38MP0004811_abnormal_neuron_physiology1.84244673
39MP0003329_amyloid_beta_deposits1.83988300
40MP0003879_abnormal_hair_cell1.77782139
41MP0003950_abnormal_plasma_membrane1.77684705
42MP0004924_abnormal_behavior1.77572733
43MP0005386_behavior/neurological_phenoty1.77572733
44MP0002184_abnormal_innervation1.76903274
45MP0002139_abnormal_hepatobiliary_system1.76757266
46MP0004858_abnormal_nervous_system1.76623670
47MP0008569_lethality_at_weaning1.72213336
48MP0003787_abnormal_imprinting1.70898891
49MP0001984_abnormal_olfaction1.70780878
50MP0003718_maternal_effect1.68876756
51MP0003186_abnormal_redox_activity1.67345026
52MP0002557_abnormal_social/conspecific_i1.66635134
53MP0000778_abnormal_nervous_system1.66399278
54MP0005174_abnormal_tail_pigmentation1.60133043
55MP0003122_maternal_imprinting1.54269117
56MP0003868_abnormal_feces_composition1.52939150
57MP0000955_abnormal_spinal_cord1.50634795
58MP0006036_abnormal_mitochondrial_physio1.50587469
59MP0000427_abnormal_hair_cycle1.50136540
60MP0008775_abnormal_heart_ventricle1.49840110
61MP0000749_muscle_degeneration1.44855724
62MP0003656_abnormal_erythrocyte_physiolo1.44727219
63MP0002837_dystrophic_cardiac_calcinosis1.44019889
64MP0000013_abnormal_adipose_tissue1.41654315
65MP0002066_abnormal_motor_capabilities/c1.40146986
66MP0005253_abnormal_eye_physiology1.39666069
67MP0002882_abnormal_neuron_morphology1.36338783
68MP0010234_abnormal_vibrissa_follicle1.30465025
69MP0001529_abnormal_vocalization1.29082994
70MP0003633_abnormal_nervous_system1.28652173
71MP0002095_abnormal_skin_pigmentation1.27587792
72MP0000751_myopathy1.26001605
73MP0005645_abnormal_hypothalamus_physiol1.25480934
74MP0001905_abnormal_dopamine_level1.24853633
75MP0005075_abnormal_melanosome_morpholog1.23859264
76MP0001502_abnormal_circadian_rhythm1.23803830
77MP0006072_abnormal_retinal_apoptosis1.20279000
78MP0000647_abnormal_sebaceous_gland1.16820270
79MP0008875_abnormal_xenobiotic_pharmacok1.16069336
80MP0005379_endocrine/exocrine_gland_phen1.15499005
81MP0010386_abnormal_urinary_bladder1.14477712
82MP0005332_abnormal_amino_acid1.12215974
83MP0002876_abnormal_thyroid_physiology1.12162549
84MP0005410_abnormal_fertilization1.11599800
85MP0004885_abnormal_endolymph1.10992025
86MP0004142_abnormal_muscle_tone1.10785118
87MP0002972_abnormal_cardiac_muscle1.08421911
88MP0002269_muscular_atrophy1.07858063
89MP0004233_abnormal_muscle_weight1.07420292
90MP0003631_nervous_system_phenotype1.07108423
91MP0001188_hyperpigmentation1.05697234
92MP0005248_abnormal_Harderian_gland1.05247756
93MP0000371_diluted_coat_color1.02469171
94MP0002229_neurodegeneration1.01414663
95MP0002332_abnormal_exercise_endurance1.01081071
96MP0002152_abnormal_brain_morphology1.00422792
97MP0000639_abnormal_adrenal_gland0.97683920
98MP0005535_abnormal_body_temperature0.96791325
99MP0002069_abnormal_eating/drinking_beha0.96624971
100MP0000569_abnormal_digit_pigmentation0.96591884
101MP0002877_abnormal_melanocyte_morpholog0.96348930
102MP0003646_muscle_fatigue0.95611771
103MP0005551_abnormal_eye_electrophysiolog0.94055048
104MP0004085_abnormal_heartbeat0.93966714
105MP0004215_abnormal_myocardial_fiber0.93126430
106MP0006035_abnormal_mitochondrial_morpho0.93015220
107MP0008872_abnormal_physiological_respon0.89810768
108MP0001661_extended_life_span0.88837627
109MP0004130_abnormal_muscle_cell0.88068497
110MP0000604_amyloidosis0.87034843
111MP0003183_abnormal_peptide_metabolism0.86940792
112MP0010329_abnormal_lipoprotein_level0.85408317
113MP0008874_decreased_physiological_sensi0.83747318
114MP0001756_abnormal_urination0.82740249
115MP0004484_altered_response_of0.79660051
116MP0000003_abnormal_adipose_tissue0.79130726
117MP0004043_abnormal_pH_regulation0.79039250
118MP0005083_abnormal_biliary_tract0.78674203
119MP0003634_abnormal_glial_cell0.78155659
120MP0001324_abnormal_eye_pigmentation0.77032449
121MP0004272_abnormal_basement_membrane0.75982120
122MP0004145_abnormal_muscle_electrophysio0.75810768
123MP0005365_abnormal_bile_salt0.73339094
124MP0001963_abnormal_hearing_physiology0.73318467
125MP0004134_abnormal_chest_morphology0.73082361
126MP0001177_atelectasis0.72738241
127MP0005395_other_phenotype0.72282059
128MP0003890_abnormal_embryonic-extraembry0.71988543
129MP0002751_abnormal_autonomic_nervous0.71839427
130MP0002177_abnormal_outer_ear0.71509159
131MP0008961_abnormal_basal_metabolism0.71453614
132MP0009840_abnormal_foam_cell0.71312729
133MP0002090_abnormal_vision0.70911026
134MP0003252_abnormal_bile_duct0.70327435
135MP0002160_abnormal_reproductive_system0.70052636
136MP0003632_abnormal_nervous_system0.68949431
137MP0002752_abnormal_somatic_nervous0.68070972
138MP0000631_abnormal_neuroendocrine_gland0.67370239
139MP0001664_abnormal_digestion0.66644590
140MP0001299_abnormal_eye_distance/0.65882357
141MP0002638_abnormal_pupillary_reflex0.60856511
142MP0005394_taste/olfaction_phenotype0.59329905
143MP0005499_abnormal_olfactory_system0.59329905
144MP0003137_abnormal_impulse_conducting0.58935603
145MP0003690_abnormal_glial_cell0.57786989
146MP0004036_abnormal_muscle_relaxation0.57567284
147MP0005187_abnormal_penis_morphology0.56689389
148MP0005620_abnormal_muscle_contractility0.55605720
149MP0004742_abnormal_vestibular_system0.54755052
150MP0003283_abnormal_digestive_organ0.54024535
151MP0003075_altered_response_to0.52523742
152MP0003956_abnormal_body_size0.51665062
153MP0003172_abnormal_lysosome_physiology0.51264442
154MP0002653_abnormal_ependyma_morphology0.50881386
155MP0005448_abnormal_energy_balance0.50615065
156MP0001943_abnormal_respiration0.50597913

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.95425852
2Myokymia (HP:0002411)5.87226138
3Focal seizures (HP:0007359)5.14865054
4Visual hallucinations (HP:0002367)4.99802550
5Atonic seizures (HP:0010819)4.97229074
6Epileptic encephalopathy (HP:0200134)4.95026025
7Febrile seizures (HP:0002373)4.45524730
8Absence seizures (HP:0002121)4.09566416
9Progressive cerebellar ataxia (HP:0002073)4.04333098
10Generalized tonic-clonic seizures (HP:0002069)3.73782067
11Hyperventilation (HP:0002883)3.71749370
12Dialeptic seizures (HP:0011146)3.67175566
13Papillary thyroid carcinoma (HP:0002895)3.60643011
14Pheochromocytoma (HP:0002666)3.54073511
15Action tremor (HP:0002345)3.48064524
16Tongue fasciculations (HP:0001308)3.39771533
17Ankle clonus (HP:0011448)3.27339562
18Impaired vibration sensation in the lower limbs (HP:0002166)3.24112327
19Neuroendocrine neoplasm (HP:0100634)3.16658890
20Depression (HP:0000716)3.15487780
21Abnormal eating behavior (HP:0100738)3.14618843
22Metaphyseal dysplasia (HP:0100255)3.14335336
23Mutism (HP:0002300)3.10004614
24Broad-based gait (HP:0002136)3.07582793
25Progressive inability to walk (HP:0002505)3.07111066
26Urinary bladder sphincter dysfunction (HP:0002839)3.06305617
27Poor eye contact (HP:0000817)3.05630569
28Supranuclear gaze palsy (HP:0000605)3.04245087
29Truncal ataxia (HP:0002078)3.03676644
30Gaze-evoked nystagmus (HP:0000640)2.97272791
31Abnormality of the fovea (HP:0000493)2.97179189
32Medial flaring of the eyebrow (HP:0010747)2.97026664
33Dysdiadochokinesis (HP:0002075)2.95949227
34Aplasia/Hypoplasia of the fovea (HP:0008060)2.94794264
35Hypoplasia of the fovea (HP:0007750)2.94794264
36Renal cortical cysts (HP:0000803)2.90879213
37Limb dystonia (HP:0002451)2.89733069
38Cutaneous melanoma (HP:0012056)2.89154148
39Impaired social interactions (HP:0000735)2.87305897
40Abnormal social behavior (HP:0012433)2.87305897
41Methylmalonic acidemia (HP:0002912)2.85847926
42Muscle fibrillation (HP:0010546)2.85765305
43Termporal pattern (HP:0011008)2.84316165
44Insidious onset (HP:0003587)2.84316165
45Polyphagia (HP:0002591)2.79521049
46Abnormality of the lower motor neuron (HP:0002366)2.79311203
47Urinary urgency (HP:0000012)2.76448637
48Anxiety (HP:0000739)2.76384930
49Genetic anticipation (HP:0003743)2.76308043
50Torticollis (HP:0000473)2.75738222
51Hypoglycemic coma (HP:0001325)2.75723764
52Drooling (HP:0002307)2.71768396
53Excessive salivation (HP:0003781)2.71768396
54Epileptiform EEG discharges (HP:0011182)2.71176232
55Papilledema (HP:0001085)2.69317787
56Ketoacidosis (HP:0001993)2.67190130
57Postural instability (HP:0002172)2.65759288
58Thyroid carcinoma (HP:0002890)2.63995888
59Dysmetric saccades (HP:0000641)2.61150468
60Amblyopia (HP:0000646)2.60531189
61EEG with generalized epileptiform discharges (HP:0011198)2.57084875
62Focal dystonia (HP:0004373)2.55931600
63Progressive macrocephaly (HP:0004481)2.54074590
64Dysmetria (HP:0001310)2.53707353
65Type II lissencephaly (HP:0007260)2.51934289
66Hypsarrhythmia (HP:0002521)2.47592602
67Inability to walk (HP:0002540)2.46728018
68Hypothermia (HP:0002045)2.46131369
69Failure to thrive in infancy (HP:0001531)2.45879247
70Scanning speech (HP:0002168)2.45204011
71Acute necrotizing encephalopathy (HP:0006965)2.44773987
72Gait imbalance (HP:0002141)2.43182063
73Agitation (HP:0000713)2.40704911
74Abnormality of the corticospinal tract (HP:0002492)2.40642874
75Bradykinesia (HP:0002067)2.39953468
76Craniofacial dystonia (HP:0012179)2.39239493
77Spastic gait (HP:0002064)2.37757681
78Hypokinesia (HP:0002375)2.31339488
79Abnormality of binocular vision (HP:0011514)2.30084410
80Diplopia (HP:0000651)2.30084410
81Proximal tubulopathy (HP:0000114)2.29104132
82Short tibia (HP:0005736)2.28736010
83Resting tremor (HP:0002322)2.28070962
84Fetal akinesia sequence (HP:0001989)2.27344715
85Hepatic necrosis (HP:0002605)2.26304017
86Neoplasm of the peripheral nervous system (HP:0100007)2.25500949
87Impaired vibratory sensation (HP:0002495)2.25410662
88Increased CSF lactate (HP:0002490)2.25368296
89Calf muscle hypertrophy (HP:0008981)2.23511211
90Acute encephalopathy (HP:0006846)2.23278935
91Aplasia/Hypoplasia of the tibia (HP:0005772)2.23217688
92Impaired smooth pursuit (HP:0007772)2.22579322
93Aplasia/Hypoplasia of the macula (HP:0008059)2.22569373
94Abnormal mitochondria in muscle tissue (HP:0008316)2.20682697
95Status epilepticus (HP:0002133)2.19592819
96Lower limb muscle weakness (HP:0007340)2.17960258
97Nephrogenic diabetes insipidus (HP:0009806)2.17356557
98Pancreatic cysts (HP:0001737)2.16467955
99Amyotrophic lateral sclerosis (HP:0007354)2.14889957
100Delayed gross motor development (HP:0002194)2.14362444
101Aplasia/hypoplasia of the uterus (HP:0008684)2.12852161
102Albinism (HP:0001022)2.12468351
103Oligomenorrhea (HP:0000876)2.12443558
1043-Methylglutaconic aciduria (HP:0003535)2.11982955
105Bundle branch block (HP:0011710)2.10992872
106Abnormality of aromatic amino acid family metabolism (HP:0004338)2.09412246
107Degeneration of anterior horn cells (HP:0002398)2.08444336
108Abnormality of the anterior horn cell (HP:0006802)2.08444336
109Akinesia (HP:0002304)2.08259764
110Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.07539090
111Decreased activity of mitochondrial respiratory chain (HP:0008972)2.07539090
112Palpitations (HP:0001962)2.07425437
113Generalized aminoaciduria (HP:0002909)2.07054324
114Congenital sensorineural hearing impairment (HP:0008527)2.07042038
115Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.06702561
116Degeneration of the lateral corticospinal tracts (HP:0002314)2.06702561
117Patchy hypopigmentation of hair (HP:0011365)2.06329798
118Abnormality of vitamin B metabolism (HP:0004340)2.05747672
119Generalized hypopigmentation (HP:0007513)2.04639017
120Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.03860482
121Epidermoid cyst (HP:0200040)2.03707449
122Methylmalonic aciduria (HP:0012120)2.03520701
123Cerebral inclusion bodies (HP:0100314)2.02597777
124Poor suck (HP:0002033)2.02375239
125Stereotypic behavior (HP:0000733)2.01663367
126Abnormality of the renal cortex (HP:0011035)2.01603237
127Generalized myoclonic seizures (HP:0002123)2.00909768
128Specific learning disability (HP:0001328)1.99958766
129Blue irides (HP:0000635)1.99423424
130Aplasia/Hypoplasia affecting the retina (HP:0008061)1.99273014
131Impaired pain sensation (HP:0007328)1.99270080
132Abnormality of pain sensation (HP:0010832)1.99270080
133Large for gestational age (HP:0001520)1.98274420
134Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98207338
135Abnormality of alanine metabolism (HP:0010916)1.98207338
136Hyperalaninemia (HP:0003348)1.98207338
137Syncope (HP:0001279)1.97655865
138Abnormality of methionine metabolism (HP:0010901)1.96463687
139Generalized hypopigmentation of hair (HP:0011358)1.96140929
140Abnormal hair whorl (HP:0010721)1.96088621
141Abnormality of ocular smooth pursuit (HP:0000617)1.95709368
142Ventricular fibrillation (HP:0001663)1.94044236
143Intention tremor (HP:0002080)1.92963672
144Hemiparesis (HP:0001269)1.92795224
145Abnormality of the calf musculature (HP:0001430)1.92773677
146Congenital primary aphakia (HP:0007707)1.92569376
147Gait ataxia (HP:0002066)1.92426248
148Muscle hypertrophy of the lower extremities (HP:0008968)1.90098145
149Absent speech (HP:0001344)1.89362240
150Upper limb muscle weakness (HP:0003484)1.88878342
151Mitochondrial inheritance (HP:0001427)1.88290512
152Hypoventilation (HP:0002791)1.88208651
153Hemiplegia (HP:0002301)1.88065781
154Abnormality of macular pigmentation (HP:0008002)1.86460174
155Megalencephaly (HP:0001355)1.86329216
156Neuronal loss in central nervous system (HP:0002529)1.86115794
157Fair hair (HP:0002286)1.85499640
158Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84310779
159Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.84251661
160Genital tract atresia (HP:0001827)1.83676729
161Cholecystitis (HP:0001082)1.83029616
162Abnormal gallbladder physiology (HP:0012438)1.83029616
163Neurofibrillary tangles (HP:0002185)1.82917702
164Renal Fanconi syndrome (HP:0001994)1.82877076
165Clonus (HP:0002169)1.82693197
166Menstrual irregularities (HP:0000858)1.80897096
167Rigidity (HP:0002063)1.79694646
168Delusions (HP:0000746)1.79093208
169Diminished movement (HP:0002374)1.79056133
170Postural tremor (HP:0002174)1.78847500
171Hypoplasia of the uterus (HP:0000013)1.78810732
172Incomplete penetrance (HP:0003829)1.78686789
173Abnormality of the vitamin B12 metabolism (HP:0004341)1.77029025
174Abnormal gallbladder morphology (HP:0012437)1.75550028
175Pachygyria (HP:0001302)1.74674016
176Retinal dysplasia (HP:0007973)1.72485073
177Glycosuria (HP:0003076)1.72069181
178Abnormality of urine glucose concentration (HP:0011016)1.72069181
179Abnormality of vitamin metabolism (HP:0100508)1.67340892
180Increased hepatocellular lipid droplets (HP:0006565)1.67252879
181Horizontal nystagmus (HP:0000666)1.66902760
182Ketosis (HP:0001946)1.66510532
183Intrahepatic cholestasis (HP:0001406)1.66031367
184X-linked dominant inheritance (HP:0001423)1.65321445
185Hyperinsulinemic hypoglycemia (HP:0000825)1.64321796
186Severe muscular hypotonia (HP:0006829)1.63724738

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.93626636
2MARK13.58864424
3MAP3K93.58859863
4TRIM283.57058835
5CASK3.30772572
6MAP3K43.23720206
7FRK3.08579836
8EPHA43.05078126
9MAP2K72.93262683
10MAP3K122.71691401
11MINK12.70497812
12DAPK22.60326944
13EIF2AK12.39799802
14MAP2K42.17481042
15ACVR1B2.08206322
16PAK62.06457300
17MST42.04931804
18KSR21.96953609
19PLK21.90484921
20EIF2AK31.86979526
21NTRK21.84172714
22DAPK11.77598847
23CDK191.74973869
24BMPR1B1.64693615
25KSR11.63555196
26CAMKK11.62670350
27CSNK1G31.61668136
28NTRK11.56871017
29CSNK1G11.52240286
30MYLK1.51579585
31CSNK1A1L1.50205869
32PRKD31.47672878
33GRK51.46284864
34MAPK131.43449779
35CDK51.41646259
36ARAF1.39902556
37LATS21.39774303
38OBSCN1.36317427
39PHKG21.35349126
40PHKG11.35349126
41STK391.33424010
42PRPF4B1.28697784
43CAMKK21.27073041
44CCNB11.23882712
45PRKCG1.22038402
46ADRBK21.13368994
47MAPKAPK31.13189177
48PDK41.13122577
49PDK31.13122577
50SGK4941.10055064
51SGK2231.10055064
52MAP3K21.09511360
53AKT31.05035809
54SGK21.04083057
55TESK11.02130051
56RIPK41.01495658
57STK380.99328386
58RET0.99122944
59NEK10.98750760
60TAOK10.95797105
61STK38L0.94859355
62NEK60.93184416
63CAMK2A0.92885650
64PLK30.91029107
65STK30.90393103
66CDK180.89891689
67OXSR10.88763609
68MAP4K20.88268465
69CDK140.87589020
70MAP2K60.87264647
71ZAK0.86604743
72LMTK20.86147062
73SGK30.85825106
74SRPK10.84910534
75PRKCH0.84416737
76CDK150.83859716
77UHMK10.79713248
78PAK30.79278468
79BMPR20.78605956
80SIK30.78541604
81SCYL20.78481098
82SIK20.77342460
83CSNK1G20.74229287
84TNIK0.74154117
85GRK10.74144971
86WNK40.72970865
87PTK2B0.71068236
88PINK10.70767112
89TGFBR20.70240684
90CDK11A0.69660589
91CAMK2B0.67265714
92MET0.66730796
93BRAF0.65666766
94MAP3K50.65461219
95DYRK1A0.65327921
96ERBB40.63962463
97MAP3K130.63815744
98PRKCE0.63544330
99STK110.63332729
100MARK30.63319616
101PDK10.60353781
102CAMK10.60143119
103RAF10.60082718
104FES0.59841351
105PRKCI0.59493964
106TYRO30.58789210
107WNK30.57455427
108SGK10.56539502
109MAP3K10.56391262
110MAP2K10.56223818
111PDPK10.55721761
112FER0.54442067
113RPS6KA20.53767441
114ERBB30.52604000
115LIMK10.52344624
116PRKCZ0.51975489
117GRK70.50574627
118STK240.49785433
119BCR0.48240467
120ALK0.46947522
121NUAK10.46548346
122PDK20.45446967
123PNCK0.45038692
124MARK20.44790274
125DAPK30.44441531
126CAMK2G0.43752440
127EPHA30.41906596
128CLK10.41852602
129PRKACA0.41774926
130RPS6KA30.41657878
131CAMK2D0.41008169
132PIK3CG0.40314666
133INSRR0.38483940
134NEK90.37869090
135MAPK120.37845899
136TIE10.37839909
137PRKG10.37156972
138BCKDK0.36936809
139MAP3K60.36857798
140CDC42BPA0.36735379
141PKN10.36466107
142BRSK20.36099239
143MUSK0.34984463
144CSNK1A10.34953248
145CSNK1D0.34714832
146RPS6KA50.34378200
147ROCK10.33514974
148NME10.33487688
149FLT30.33461967
150TSSK60.32887187
151ADRBK10.32329231
152FYN0.32321899

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.91952641
2Nicotine addiction_Homo sapiens_hsa050333.41934291
3Protein export_Homo sapiens_hsa030603.20241368
4Sulfur metabolism_Homo sapiens_hsa009202.71119267
5Olfactory transduction_Homo sapiens_hsa047402.68027898
6GABAergic synapse_Homo sapiens_hsa047272.60497819
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.47439921
8Circadian entrainment_Homo sapiens_hsa047132.45345320
9Long-term potentiation_Homo sapiens_hsa047202.37575023
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.37276981
11Morphine addiction_Homo sapiens_hsa050322.31183825
12Collecting duct acid secretion_Homo sapiens_hsa049662.28832432
13Amphetamine addiction_Homo sapiens_hsa050312.25548478
14Steroid biosynthesis_Homo sapiens_hsa001002.23887927
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20504003
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18549191
17Glutamatergic synapse_Homo sapiens_hsa047242.17353000
18Dopaminergic synapse_Homo sapiens_hsa047282.11608337
19Fatty acid elongation_Homo sapiens_hsa000622.09112709
20Primary bile acid biosynthesis_Homo sapiens_hsa001202.06509271
21Insulin secretion_Homo sapiens_hsa049112.02201827
22Basal transcription factors_Homo sapiens_hsa030221.91446538
23Propanoate metabolism_Homo sapiens_hsa006401.89842862
24Salivary secretion_Homo sapiens_hsa049701.84793114
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82787571
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.74949764
27Cholinergic synapse_Homo sapiens_hsa047251.71846863
28Caffeine metabolism_Homo sapiens_hsa002321.71452099
29Gastric acid secretion_Homo sapiens_hsa049711.61140531
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60602273
31Taste transduction_Homo sapiens_hsa047421.60159484
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53618985
33Renin secretion_Homo sapiens_hsa049241.53338814
34Vibrio cholerae infection_Homo sapiens_hsa051101.52998599
35Cocaine addiction_Homo sapiens_hsa050301.52713950
36Parkinsons disease_Homo sapiens_hsa050121.49167032
37Long-term depression_Homo sapiens_hsa047301.47781164
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47209570
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46143427
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.45902760
41Serotonergic synapse_Homo sapiens_hsa047261.45476403
42Oxytocin signaling pathway_Homo sapiens_hsa049211.42283904
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.41845811
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.37051634
45Calcium signaling pathway_Homo sapiens_hsa040201.33701552
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32444599
47Proteasome_Homo sapiens_hsa030501.30993589
48Non-homologous end-joining_Homo sapiens_hsa034501.28467384
49Gap junction_Homo sapiens_hsa045401.26802400
50Tryptophan metabolism_Homo sapiens_hsa003801.22812794
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21271081
52GnRH signaling pathway_Homo sapiens_hsa049121.20675513
53Fatty acid metabolism_Homo sapiens_hsa012121.19925040
54Type II diabetes mellitus_Homo sapiens_hsa049301.19873755
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.18561103
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17880264
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17267974
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15741238
59Peroxisome_Homo sapiens_hsa041461.13303189
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13241370
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10856185
62cAMP signaling pathway_Homo sapiens_hsa040241.07383908
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.05924848
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05306363
65Regulation of autophagy_Homo sapiens_hsa041401.03966170
66beta-Alanine metabolism_Homo sapiens_hsa004101.02272229
67Estrogen signaling pathway_Homo sapiens_hsa049151.00257483
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99979644
69Glioma_Homo sapiens_hsa052140.98357217
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98109015
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97495906
72Sphingolipid metabolism_Homo sapiens_hsa006000.97123811
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95680643
74Fatty acid degradation_Homo sapiens_hsa000710.94953514
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94763570
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93520237
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92460361
78ErbB signaling pathway_Homo sapiens_hsa040120.92359140
79Axon guidance_Homo sapiens_hsa043600.91089950
80Chemical carcinogenesis_Homo sapiens_hsa052040.90104372
81Selenocompound metabolism_Homo sapiens_hsa004500.88651499
82Folate biosynthesis_Homo sapiens_hsa007900.88504598
83Vitamin B6 metabolism_Homo sapiens_hsa007500.87031495
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86222777
85Phototransduction_Homo sapiens_hsa047440.84863002
86Cardiac muscle contraction_Homo sapiens_hsa042600.83920428
87Huntingtons disease_Homo sapiens_hsa050160.82620034
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82168893
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79442313
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79055777
91Melanogenesis_Homo sapiens_hsa049160.78908659
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.77048878
93Oocyte meiosis_Homo sapiens_hsa041140.76974773
94Arginine and proline metabolism_Homo sapiens_hsa003300.76025357
95RNA degradation_Homo sapiens_hsa030180.75422519
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73999485
97PPAR signaling pathway_Homo sapiens_hsa033200.73279066
98Glucagon signaling pathway_Homo sapiens_hsa049220.72308952
99Fatty acid biosynthesis_Homo sapiens_hsa000610.71380459
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70432419
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70375797
102Metabolic pathways_Homo sapiens_hsa011000.69592288
103Butanoate metabolism_Homo sapiens_hsa006500.68189357
104Dilated cardiomyopathy_Homo sapiens_hsa054140.66041067
105Thyroid hormone synthesis_Homo sapiens_hsa049180.64610964
106Retinol metabolism_Homo sapiens_hsa008300.64557825
107Nitrogen metabolism_Homo sapiens_hsa009100.62489779
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62336342
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62279385
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.61930282
111Mineral absorption_Homo sapiens_hsa049780.61114542
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60778378
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60467095
114Type I diabetes mellitus_Homo sapiens_hsa049400.59987214
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59403278
116MAPK signaling pathway_Homo sapiens_hsa040100.58227829
117Pancreatic secretion_Homo sapiens_hsa049720.58127466
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.58073629
119Dorso-ventral axis formation_Homo sapiens_hsa043200.57980085
120Insulin signaling pathway_Homo sapiens_hsa049100.56854305
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56797334
122Circadian rhythm_Homo sapiens_hsa047100.55464537
123Bile secretion_Homo sapiens_hsa049760.54807243
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53866573
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53678295
126mTOR signaling pathway_Homo sapiens_hsa041500.53408154
127Linoleic acid metabolism_Homo sapiens_hsa005910.53197928
128Endometrial cancer_Homo sapiens_hsa052130.52877547
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.52448759
130ABC transporters_Homo sapiens_hsa020100.52133701
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50105560
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49902313
133Glutathione metabolism_Homo sapiens_hsa004800.48866173
134Pyruvate metabolism_Homo sapiens_hsa006200.47530746
135Ras signaling pathway_Homo sapiens_hsa040140.47502515
136Carbon metabolism_Homo sapiens_hsa012000.45509309
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45284305
138Choline metabolism in cancer_Homo sapiens_hsa052310.45143680
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45076884
140TGF-beta signaling pathway_Homo sapiens_hsa043500.44891378
141Endocytosis_Homo sapiens_hsa041440.44806276
142Phagosome_Homo sapiens_hsa041450.44041102
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43528129
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43304304
145Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42739339
146Rheumatoid arthritis_Homo sapiens_hsa053230.42672040
147VEGF signaling pathway_Homo sapiens_hsa043700.42554733
148Oxidative phosphorylation_Homo sapiens_hsa001900.42368578
149Arginine biosynthesis_Homo sapiens_hsa002200.40953846
150Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40154908
151Alzheimers disease_Homo sapiens_hsa050100.39862032
152Inositol phosphate metabolism_Homo sapiens_hsa005620.38654029
153Rap1 signaling pathway_Homo sapiens_hsa040150.38136135
154Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37601760
155Renal cell carcinoma_Homo sapiens_hsa052110.37242141
156Starch and sucrose metabolism_Homo sapiens_hsa005000.37205757
157Ovarian steroidogenesis_Homo sapiens_hsa049130.36177755
158Alcoholism_Homo sapiens_hsa050340.36055243
159Prion diseases_Homo sapiens_hsa050200.34902721
160Sphingolipid signaling pathway_Homo sapiens_hsa040710.33595806
161Non-small cell lung cancer_Homo sapiens_hsa052230.30701609
162Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30547405

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