RNF141

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. Abundant expression of this gene was found in the testicular tissue of fertile men, but was not detected in azoospermic patients. Studies of the mouse counterpart suggest that this gene may function as a testis specific transcription factor during spermatogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.37732423
2central nervous system myelination (GO:0022010)7.37732423
3fatty acid elongation (GO:0030497)4.75344879
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.66491997
5L-phenylalanine catabolic process (GO:0006559)4.66491997
6glycerophospholipid catabolic process (GO:0046475)4.23766796
7synaptic vesicle maturation (GO:0016188)4.18749094
8axon ensheathment (GO:0008366)4.03774043
9ensheathment of neurons (GO:0007272)4.03774043
10myelination (GO:0042552)4.01410539
11myelin maintenance (GO:0043217)3.97842850
12L-phenylalanine metabolic process (GO:0006558)3.96915357
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.96915357
14neurotransmitter uptake (GO:0001504)3.93246452
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.88180663
16epithelial cilium movement (GO:0003351)3.60628549
17long-chain fatty acid biosynthetic process (GO:0042759)3.59352093
18microglial cell activation (GO:0001774)3.51511711
19negative regulation of neurotransmitter secretion (GO:0046929)3.48029537
20regulation of synaptic vesicle exocytosis (GO:2000300)3.42648456
21response to methylmercury (GO:0051597)3.42138225
22pyrimidine nucleobase catabolic process (GO:0006208)3.39861643
23nucleobase catabolic process (GO:0046113)3.39051724
24long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.34289674
25C4-dicarboxylate transport (GO:0015740)3.28965257
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.26258810
27negative regulation of neurotransmitter transport (GO:0051589)3.25429320
28auditory behavior (GO:0031223)3.20069133
29neuron cell-cell adhesion (GO:0007158)3.19616020
30regulation of cilium movement (GO:0003352)3.16163884
31postsynaptic membrane organization (GO:0001941)3.15785205
32locomotory exploration behavior (GO:0035641)3.14627906
33positive regulation of oligodendrocyte differentiation (GO:0048714)3.13078052
34fatty-acyl-CoA biosynthetic process (GO:0046949)3.11992526
35cilium movement (GO:0003341)3.10904461
36photoreceptor cell differentiation (GO:0046530)3.07967036
37eye photoreceptor cell differentiation (GO:0001754)3.07967036
38regulation of synapse structural plasticity (GO:0051823)3.06987383
39establishment of mitochondrion localization (GO:0051654)3.06745486
40apical protein localization (GO:0045176)3.05879182
41axonemal dynein complex assembly (GO:0070286)3.04574797
42regulation of lipoprotein metabolic process (GO:0050746)3.03078904
43response to lipoprotein particle (GO:0055094)3.01195465
44alpha-linolenic acid metabolic process (GO:0036109)2.99823718
45response to redox state (GO:0051775)2.99595262
46cholesterol biosynthetic process (GO:0006695)2.96812035
47synaptic vesicle exocytosis (GO:0016079)2.94953140
48aromatic amino acid family catabolic process (GO:0009074)2.93397802
49cell wall macromolecule catabolic process (GO:0016998)2.91898539
50very long-chain fatty acid metabolic process (GO:0000038)2.91311748
51long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.89520574
52regulation of acyl-CoA biosynthetic process (GO:0050812)2.88187029
53regulation of synaptic vesicle transport (GO:1902803)2.85209958
54L-amino acid import (GO:0043092)2.83319214
55oligodendrocyte differentiation (GO:0048709)2.83287736
56asymmetric protein localization (GO:0008105)2.83277069
57regulation of pigment cell differentiation (GO:0050932)2.81915407
58fatty-acyl-CoA metabolic process (GO:0035337)2.81738302
59cellular response to leptin stimulus (GO:0044320)2.80624772
60regulation of cell communication by electrical coupling (GO:0010649)2.80498624
61ionotropic glutamate receptor signaling pathway (GO:0035235)2.80039039
62glutamate secretion (GO:0014047)2.79754221
63macroautophagy (GO:0016236)2.79272231
64creatine metabolic process (GO:0006600)2.77935072
65glutamate receptor signaling pathway (GO:0007215)2.77291899
66response to dietary excess (GO:0002021)2.76771235
67protein localization to cilium (GO:0061512)2.72251659
68vocalization behavior (GO:0071625)2.71989302
69cilium or flagellum-dependent cell motility (GO:0001539)2.70545780
70nonmotile primary cilium assembly (GO:0035058)2.69336357
71magnesium ion transport (GO:0015693)2.68024766
72cell wall macromolecule metabolic process (GO:0044036)2.67717056
73gamma-aminobutyric acid transport (GO:0015812)2.67426609
74regulation of relaxation of muscle (GO:1901077)2.66646767
75cellular ketone body metabolic process (GO:0046950)2.66627957
76regulation of short-term neuronal synaptic plasticity (GO:0048172)2.66283029
77glycine transport (GO:0015816)2.64017423
78detection of calcium ion (GO:0005513)2.63174170
79regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.61797766
80Golgi to endosome transport (GO:0006895)2.61756529
81neural tube formation (GO:0001841)2.61657079
82sterol biosynthetic process (GO:0016126)2.61152011
83neutrophil mediated immunity (GO:0002446)2.58226479
84regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.58178113
85dendritic spine morphogenesis (GO:0060997)2.58109670
86neuron-neuron synaptic transmission (GO:0007270)2.57000013
87exploration behavior (GO:0035640)2.56912007
88regulation of beta-amyloid formation (GO:1902003)2.56658868
89detection of molecule of bacterial origin (GO:0032490)2.55203902
90regulation of synaptic transmission, glutamatergic (GO:0051966)2.55035142
91cerebral cortex radially oriented cell migration (GO:0021799)2.54525066
92import into cell (GO:0098657)2.53955543
93amyloid precursor protein metabolic process (GO:0042982)2.53467257
94platelet dense granule organization (GO:0060155)2.52918984
95synaptic transmission, glutamatergic (GO:0035249)2.52868441
96peptidyl-tyrosine autophosphorylation (GO:0038083)2.52832477
97negative regulation of synaptic transmission, GABAergic (GO:0032229)2.52824215
98G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.52754131
99protein localization to synapse (GO:0035418)2.52482880
100mechanosensory behavior (GO:0007638)2.52007292
101nerve growth factor signaling pathway (GO:0038180)2.51644593
102protein localization to endosome (GO:0036010)2.51405014
103response to leptin (GO:0044321)2.50950699
104response to auditory stimulus (GO:0010996)2.50273872
105regulation of cholesterol biosynthetic process (GO:0045540)2.49492175
106positive regulation of microtubule polymerization (GO:0031116)2.48450211
107regulation of coenzyme metabolic process (GO:0051196)2.48158938
108regulation of cofactor metabolic process (GO:0051193)2.48158938
109regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.47659649
110bile acid biosynthetic process (GO:0006699)2.47319458
111cilium morphogenesis (GO:0060271)2.47268419
112positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.47053257
113anterograde synaptic vesicle transport (GO:0048490)2.46810088
114protein targeting to Golgi (GO:0000042)2.46786961
115regulation of collateral sprouting (GO:0048670)2.45808189
116thioester biosynthetic process (GO:0035384)2.45423891
117acyl-CoA biosynthetic process (GO:0071616)2.45423891
118negative regulation of protein localization to cell surface (GO:2000009)2.45266671
119regulation of interleukin-6 biosynthetic process (GO:0045408)2.45033950
120growth hormone receptor signaling pathway (GO:0060396)2.44997097
121complement activation, alternative pathway (GO:0006957)2.44912800
122intraciliary transport (GO:0042073)2.44790668
123negative regulation of adenylate cyclase activity (GO:0007194)2.43561025
124negative regulation of response to food (GO:0032096)2.43405763
125negative regulation of appetite (GO:0032099)2.43405763
126establishment of protein localization to Golgi (GO:0072600)2.42773042
127amino acid import (GO:0043090)2.42682145
128neuron fate determination (GO:0048664)2.42559367
129righting reflex (GO:0060013)2.41668594
130presynaptic membrane organization (GO:0097090)2.39926679
131regulation of protein glycosylation (GO:0060049)2.39453653
132tyrosine metabolic process (GO:0006570)2.39022218
133glycerolipid catabolic process (GO:0046503)2.38774881
134regulation of neurotransmitter uptake (GO:0051580)2.38716476
135negative regulation of oligodendrocyte differentiation (GO:0048715)2.38136988
136type B pancreatic cell development (GO:0003323)2.37945897
137neutrophil activation involved in immune response (GO:0002283)2.37033677
138proline transport (GO:0015824)2.36442718
139relaxation of smooth muscle (GO:0044557)2.36431319
140regulation of sulfur metabolic process (GO:0042762)2.36339844
141amyloid precursor protein catabolic process (GO:0042987)2.36198468
142membrane tubulation (GO:0097320)2.35942887
143regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.35468569
144positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.35183722
145neurotransmitter-gated ion channel clustering (GO:0072578)2.34763095
146acidic amino acid transport (GO:0015800)2.34758101
147ketone body metabolic process (GO:1902224)2.34309589
148plasma lipoprotein particle clearance (GO:0034381)2.34308502
149neurotransmitter secretion (GO:0007269)2.34225314
150behavioral response to cocaine (GO:0048148)2.33756719
151neuronal action potential propagation (GO:0019227)2.33678612
152negative regulation of cyclase activity (GO:0031280)2.33465818
153cysteine metabolic process (GO:0006534)2.32518782
154triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.32025263
155bile acid metabolic process (GO:0008206)2.31931287
156coenzyme catabolic process (GO:0009109)2.31124724
157regulation of bile acid biosynthetic process (GO:0070857)2.30018915
158adult walking behavior (GO:0007628)2.29789610
159peripheral nervous system axon ensheathment (GO:0032292)2.29352584
160myelination in peripheral nervous system (GO:0022011)2.29352584
161dicarboxylic acid catabolic process (GO:0043649)2.27520418
162axon development (GO:0061564)2.26529471
163peroxisome fission (GO:0016559)2.25586067
164presynaptic membrane assembly (GO:0097105)2.23346718
165ER overload response (GO:0006983)2.22589045
166positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.22523993
167sphingosine metabolic process (GO:0006670)2.20704082
168cholesterol efflux (GO:0033344)2.19855787
169negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.18155167
170peroxisome organization (GO:0007031)2.16307385
171positive regulation of cellular amine metabolic process (GO:0033240)2.15540686
172acylglycerol biosynthetic process (GO:0046463)2.15293920
173neutral lipid biosynthetic process (GO:0046460)2.15293920
174regulation of cholesterol metabolic process (GO:0090181)2.14874889
175neuron remodeling (GO:0016322)2.12812907
176regulation of ARF protein signal transduction (GO:0032012)2.12507377
177triglyceride biosynthetic process (GO:0019432)2.12379625
178prostate gland growth (GO:0060736)2.12300275
179cholesterol metabolic process (GO:0008203)2.12138341
180cellular response to growth hormone stimulus (GO:0071378)2.10475255
181endocrine pancreas development (GO:0031018)2.10356160
182regulation of autophagic vacuole assembly (GO:2000785)2.08937805
183positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.08581004
184cofactor catabolic process (GO:0051187)2.08470477
185glycosylceramide metabolic process (GO:0006677)2.07633587
186negative regulation of inclusion body assembly (GO:0090084)2.07574363

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human2.76418915
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.25674203
3FLI1_27457419_Chip-Seq_LIVER_Mouse2.10662624
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.08389157
5LXR_22158963_ChIP-Seq_LIVER_Mouse1.96902489
6* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.94134222
7* RXR_22158963_ChIP-Seq_LIVER_Mouse1.92395732
8POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90806263
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87674387
10PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83503106
11AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81221661
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80427303
13ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79844271
14CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79644814
15TAF15_26573619_Chip-Seq_HEK293_Human1.76952079
16OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71407853
17PIAS1_25552417_ChIP-Seq_VCAP_Human1.66644407
18SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61505487
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.61396907
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56734326
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55249887
22TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54896013
23BCAT_22108803_ChIP-Seq_LS180_Human1.50550191
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49751627
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49074764
26EWS_26573619_Chip-Seq_HEK293_Human1.47837935
27STAT3_23295773_ChIP-Seq_U87_Human1.47367920
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46192704
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.46009957
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.45761202
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.45340735
32E2F1_18555785_Chip-Seq_ESCs_Mouse1.45134479
33AR_21572438_ChIP-Seq_LNCaP_Human1.44280420
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42553697
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.42464671
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42248534
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42003287
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.41291840
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41197226
40CBP_20019798_ChIP-Seq_JUKART_Human1.41197226
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40672064
42TCF4_22108803_ChIP-Seq_LS180_Human1.37850143
43TP53_16413492_ChIP-PET_HCT116_Human1.37560644
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35008742
45P300_19829295_ChIP-Seq_ESCs_Human1.34617008
46SMAD4_21799915_ChIP-Seq_A2780_Human1.33187046
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.32763827
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31857369
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30829783
50FOXA2_19822575_ChIP-Seq_HepG2_Human1.29915443
51ER_23166858_ChIP-Seq_MCF-7_Human1.29041550
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.28994307
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27842671
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27321886
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26001493
56CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25607526
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.24773581
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24603925
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24603925
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.24169183
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23801760
62P300_18555785_Chip-Seq_ESCs_Mouse1.22019496
63* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21482516
64* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21482516
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21318070
66EZH2_22144423_ChIP-Seq_EOC_Human1.21243703
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21223968
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20674073
69PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20661686
70EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.20422799
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19506643
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.17153742
73* CDX2_22108803_ChIP-Seq_LS180_Human1.16963114
74HTT_18923047_ChIP-ChIP_STHdh_Human1.16835760
75EP300_21415370_ChIP-Seq_HL-1_Mouse1.16509023
76ZNF274_21170338_ChIP-Seq_K562_Hela1.16505115
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16031099
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15048042
79TCF4_23295773_ChIP-Seq_U87_Human1.14744363
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14273245
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13778805
82NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13701525
83NANOG_19829295_ChIP-Seq_ESCs_Human1.13451363
84SOX2_19829295_ChIP-Seq_ESCs_Human1.13451363
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13095094
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.12905831
87* RUNX2_22187159_ChIP-Seq_PCA_Human1.12863586
88RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12718769
89EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12718769
90CMYC_18555785_Chip-Seq_ESCs_Mouse1.12331446
91LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12316652
92OCT4_18555785_Chip-Seq_ESCs_Mouse1.11532002
93FOXA1_25552417_ChIP-Seq_VCAP_Human1.11178162
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11006902
95JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10703026
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10603939
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10522054
98TP53_18474530_ChIP-ChIP_U2OS_Human1.10058631
99* JUN_21703547_ChIP-Seq_K562_Human1.09807184
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08493333
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.08418640
102SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08130349
103* IGF1R_20145208_ChIP-Seq_DFB_Human1.07975050
104OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07476517
105SOX2_21211035_ChIP-Seq_LN229_Gbm1.07258995
106KDM2B_26808549_Chip-Seq_REH_Human1.07180030
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06555821
108TAL1_26923725_Chip-Seq_HPCs_Mouse1.06549669
109* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06477041
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06388901
111SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06222888
112DROSHA_22980978_ChIP-Seq_HELA_Human1.05680370
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05467797
114NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05065896
115AHR_22903824_ChIP-Seq_MCF-7_Human1.04622917
116AR_25329375_ChIP-Seq_VCAP_Human1.04534519
117STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03335491
118REST_21632747_ChIP-Seq_MESCs_Mouse1.03104482
119P53_22387025_ChIP-Seq_ESCs_Mouse1.02937097
120FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02595424
121NMYC_18555785_Chip-Seq_ESCs_Mouse1.02515567
122CTCF_18555785_Chip-Seq_ESCs_Mouse1.02409502
123PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02175253
124WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02123660
125RNF2_27304074_Chip-Seq_ESCs_Mouse1.01869179
126FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01320133
127STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00644480
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00614694
129EZH2_27294783_Chip-Seq_ESCs_Mouse1.00606041
130PRDM14_20953172_ChIP-Seq_ESCs_Human1.00029129
131FOXO3_23340844_ChIP-Seq_DLD1_Human1.00006811
132EZH2_27294783_Chip-Seq_NPCs_Mouse0.99768572
133AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99459078
134SOX2_18555785_Chip-Seq_ESCs_Mouse0.98931390
135VDR_22108803_ChIP-Seq_LS180_Human0.98783847
136LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98762466
137* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98724718
138SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98452594
139RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97960724
140KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97832252
141GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97740927
142FUS_26573619_Chip-Seq_HEK293_Human0.97042167
143STAT3_18555785_Chip-Seq_ESCs_Mouse0.96708888
144SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96576222

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.30001055
2MP0000920_abnormal_myelination3.70486466
3MP0002139_abnormal_hepatobiliary_system3.57049365
4MP0004270_analgesia3.25206002
5MP0003329_amyloid_beta_deposits3.08911466
6MP0005451_abnormal_body_composition2.98918077
7MP0005365_abnormal_bile_salt2.98151678
8MP0003690_abnormal_glial_cell2.86129942
9MP0005360_urolithiasis2.84132230
10MP0005085_abnormal_gallbladder_physiolo2.49325479
11MP0003724_increased_susceptibility_to2.47494320
12MP0002638_abnormal_pupillary_reflex2.39490347
13MP0005248_abnormal_Harderian_gland2.39455308
14MP0001984_abnormal_olfaction2.38168644
15MP0009840_abnormal_foam_cell2.34119860
16MP0005408_hypopigmentation2.27122171
17MP0009780_abnormal_chondrocyte_physiolo2.26879773
18MP0008875_abnormal_xenobiotic_pharmacok2.18743908
19MP0000604_amyloidosis2.08732507
20MP0000462_abnormal_digestive_system2.05220708
21MP0003950_abnormal_plasma_membrane2.03187986
22MP0001529_abnormal_vocalization1.97052207
23MP0003195_calcinosis1.96008046
24MP0003252_abnormal_bile_duct1.95067972
25MP0004043_abnormal_pH_regulation1.94229947
26MP0004885_abnormal_endolymph1.92171856
27MP0003880_abnormal_central_pattern1.87589811
28MP0001968_abnormal_touch/_nociception1.83013888
29MP0003806_abnormal_nucleotide_metabolis1.82740118
30MP0003011_delayed_dark_adaptation1.81218479
31MP0003634_abnormal_glial_cell1.79898807
32MP0004859_abnormal_synaptic_plasticity1.78841968
33MP0003632_abnormal_nervous_system1.78760369
34MP0001486_abnormal_startle_reflex1.78668214
35MP0005646_abnormal_pituitary_gland1.75163896
36MP0000427_abnormal_hair_cycle1.69026145
37MP0003868_abnormal_feces_composition1.68405771
38MP0008260_abnormal_autophagy1.64214467
39MP0002736_abnormal_nociception_after1.63434053
40MP0002095_abnormal_skin_pigmentation1.61428152
41MP0010234_abnormal_vibrissa_follicle1.61304374
42MP0002118_abnormal_lipid_homeostasis1.61006837
43MP0003136_yellow_coat_color1.60385933
44MP0001666_abnormal_nutrient_absorption1.56684560
45MP0005174_abnormal_tail_pigmentation1.56566524
46MP0010678_abnormal_skin_adnexa1.55591699
47MP0002272_abnormal_nervous_system1.53651666
48MP0005167_abnormal_blood-brain_barrier1.52380175
49MP0005253_abnormal_eye_physiology1.51680672
50MP0004484_altered_response_of1.50402231
51MP0003631_nervous_system_phenotype1.49310525
52MP0010329_abnormal_lipoprotein_level1.49297959
53MP0002734_abnormal_mechanical_nocicepti1.48089903
54MP0003656_abnormal_erythrocyte_physiolo1.46889361
55MP0003633_abnormal_nervous_system1.42964523
56MP0004185_abnormal_adipocyte_glucose1.42832348
57MP0000639_abnormal_adrenal_gland1.41553386
58MP0002229_neurodegeneration1.41506675
59MP0003828_pulmonary_edema1.41086309
60MP0006276_abnormal_autonomic_nervous1.40323225
61MP0003635_abnormal_synaptic_transmissio1.39962814
62MP0004883_abnormal_blood_vessel1.39313043
63MP0003787_abnormal_imprinting1.39040349
64MP0000778_abnormal_nervous_system1.37703236
65MP0002064_seizures1.32871667
66MP0000579_abnormal_nail_morphology1.31728437
67MP0001188_hyperpigmentation1.31230345
68MP0001905_abnormal_dopamine_level1.30394975
69MP0005423_abnormal_somatic_nervous1.25493812
70MP0002837_dystrophic_cardiac_calcinosis1.25360130
71MP0002822_catalepsy1.24438326
72MP0001501_abnormal_sleep_pattern1.24030570
73MP0005410_abnormal_fertilization1.23333417
74MP0004742_abnormal_vestibular_system1.20580934
75MP0001440_abnormal_grooming_behavior1.19998427
76MP0004215_abnormal_myocardial_fiber1.17157390
77MP0002928_abnormal_bile_duct1.16747072
78MP0001661_extended_life_span1.16281383
79MP0005379_endocrine/exocrine_gland_phen1.14262367
80MP0005332_abnormal_amino_acid1.12875839
81MP0002735_abnormal_chemical_nociception1.12550047
82MP0009379_abnormal_foot_pigmentation1.12419104
83MP0001346_abnormal_lacrimal_gland1.12114174
84MP0005058_abnormal_lysosome_morphology1.11773982
85MP0003191_abnormal_cellular_cholesterol1.11683728
86MP0008569_lethality_at_weaning1.10541060
87MP0001177_atelectasis1.09606332
88MP0005386_behavior/neurological_phenoty1.08250557
89MP0004924_abnormal_behavior1.08250557
90MP0000566_synostosis1.08173071
91MP0000015_abnormal_ear_pigmentation1.08103873
92MP0005083_abnormal_biliary_tract1.08009502
93MP0002063_abnormal_learning/memory/cond1.07322778
94MP0000955_abnormal_spinal_cord1.05355643
95MP0002090_abnormal_vision1.05213013
96MP0001502_abnormal_circadian_rhythm1.03878258
97MP0000383_abnormal_hair_follicle1.02798515
98MP0004142_abnormal_muscle_tone1.02609557
99MP0004811_abnormal_neuron_physiology1.02442250
100MP0004147_increased_porphyrin_level1.00869129
101MP0002909_abnormal_adrenal_gland1.00840919
102MP0001851_eye_inflammation0.97723568
103MP0000749_muscle_degeneration0.97423970
104MP0002557_abnormal_social/conspecific_i0.96342322
105MP0001970_abnormal_pain_threshold0.95093734
106MP0001963_abnormal_hearing_physiology0.94949157
107MP0000003_abnormal_adipose_tissue0.94928516
108MP0002733_abnormal_thermal_nociception0.93688015
109MP0000647_abnormal_sebaceous_gland0.93651625
110MP0009745_abnormal_behavioral_response0.92953857
111MP0005171_absent_coat_pigmentation0.92276965
112MP0002572_abnormal_emotion/affect_behav0.92243499
113MP0001299_abnormal_eye_distance/0.91759205
114MP0003183_abnormal_peptide_metabolism0.91407832
115MP0002078_abnormal_glucose_homeostasis0.90434086
116MP0000013_abnormal_adipose_tissue0.89784188
117MP0002066_abnormal_motor_capabilities/c0.89244639
118MP0002133_abnormal_respiratory_system0.88920048
119MP0005388_respiratory_system_phenotype0.88920048
120MP0005310_abnormal_salivary_gland0.88873398
121MP0009046_muscle_twitch0.88475274
122MP0002877_abnormal_melanocyte_morpholog0.88011861
123MP0002102_abnormal_ear_morphology0.87069218
124MP0010368_abnormal_lymphatic_system0.86911605
125MP0000609_abnormal_liver_physiology0.83663786
126MP0005535_abnormal_body_temperature0.83498478
127MP0002882_abnormal_neuron_morphology0.83383200
128MP0001944_abnormal_pancreas_morphology0.82677690
129MP0005647_abnormal_sex_gland0.81777998
130MP0005584_abnormal_enzyme/coenzyme_acti0.81710481
131MP0004130_abnormal_muscle_cell0.81658252
132MP0002277_abnormal_respiratory_mucosa0.81382675
133MP0002067_abnormal_sensory_capabilities0.80450203
134MP0005551_abnormal_eye_electrophysiolog0.80221844
135MP0004264_abnormal_extraembryonic_tissu0.79994120
136MP0001485_abnormal_pinna_reflex0.78464334
137MP0002332_abnormal_exercise_endurance0.77921183
138MP0003718_maternal_effect0.77817739
139MP0003221_abnormal_cardiomyocyte_apopto0.77788708
140MP0002653_abnormal_ependyma_morphology0.77644683
141MP0002693_abnormal_pancreas_physiology0.76781340
142MP0005187_abnormal_penis_morphology0.76633321
143MP0001324_abnormal_eye_pigmentation0.76018689
144MP0008877_abnormal_DNA_methylation0.75938386
145MP0010386_abnormal_urinary_bladder0.75752918
146MP0005195_abnormal_posterior_eye0.74487479
147MP0000026_abnormal_inner_ear0.72464492
148MP0005620_abnormal_muscle_contractility0.69706255

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)6.22489426
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.75066388
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.70136602
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.70136602
5Cerebral inclusion bodies (HP:0100314)4.68228879
6Abnormality of the corticospinal tract (HP:0002492)3.98283029
7Intrahepatic cholestasis (HP:0001406)3.90210347
8Gait imbalance (HP:0002141)3.75289139
9Insidious onset (HP:0003587)3.71596957
10Termporal pattern (HP:0011008)3.71596957
11True hermaphroditism (HP:0010459)3.68091133
12Supranuclear gaze palsy (HP:0000605)3.66729146
13Onion bulb formation (HP:0003383)3.53066152
14Medial flaring of the eyebrow (HP:0010747)3.49685038
15Absent/shortened dynein arms (HP:0200106)3.45592772
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.45592772
17Congenital primary aphakia (HP:0007707)3.41457375
18Sensory axonal neuropathy (HP:0003390)3.40883708
19Peripheral hypomyelination (HP:0007182)3.38875653
20Pancreatic fibrosis (HP:0100732)3.34104832
21Deep venous thrombosis (HP:0002625)3.33069693
22Pancreatic cysts (HP:0001737)3.30437548
23Nephrogenic diabetes insipidus (HP:0009806)3.18845084
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.17386115
25Segmental peripheral demyelination/remyelination (HP:0003481)3.14792134
26Spastic gait (HP:0002064)3.06218884
27Xanthomatosis (HP:0000991)3.05721853
28Abnormal respiratory epithelium morphology (HP:0012253)3.01458138
29Abnormal respiratory motile cilium morphology (HP:0005938)3.01458138
30Abnormal auditory evoked potentials (HP:0006958)2.99919673
31Spastic tetraparesis (HP:0001285)2.98902479
32Cerebral hemorrhage (HP:0001342)2.97086916
33Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.96445221
34Abnormal respiratory motile cilium physiology (HP:0012261)2.94312809
35Hypoglycemic seizures (HP:0002173)2.89500202
36Abnormal ciliary motility (HP:0012262)2.88358301
37Epidermoid cyst (HP:0200040)2.86474690
38Hemiplegia (HP:0002301)2.79408458
39Complement deficiency (HP:0004431)2.79079632
40Parakeratosis (HP:0001036)2.77776711
41Intention tremor (HP:0002080)2.77601922
42Hyperlipoproteinemia (HP:0010980)2.76895252
43Hyperinsulinemic hypoglycemia (HP:0000825)2.66762881
44Abnormality of midbrain morphology (HP:0002418)2.63957458
45Molar tooth sign on MRI (HP:0002419)2.63957458
46Dysmetria (HP:0001310)2.62063707
47Hypoglycemic coma (HP:0001325)2.61092494
48Vaginal atresia (HP:0000148)2.60393861
49Peripheral demyelination (HP:0011096)2.59076904
50Febrile seizures (HP:0002373)2.58890581
51Genital tract atresia (HP:0001827)2.58720729
52Chronic hepatic failure (HP:0100626)2.56676400
53Myokymia (HP:0002411)2.54287033
54Papillary thyroid carcinoma (HP:0002895)2.54017207
55Exercise-induced muscle cramps (HP:0003710)2.52816847
56Polyphagia (HP:0002591)2.47736645
57Rhinitis (HP:0012384)2.46019122
58Nephronophthisis (HP:0000090)2.43994131
59Abnormality of the axillary hair (HP:0100134)2.42716057
60Abnormality of secondary sexual hair (HP:0009888)2.42716057
61Thickened helices (HP:0000391)2.40046224
62Ankle clonus (HP:0011448)2.39741495
63Atonic seizures (HP:0010819)2.37457860
64Decreased central vision (HP:0007663)2.37114290
65Slow saccadic eye movements (HP:0000514)2.36746590
66Paraparesis (HP:0002385)2.34399790
67Specific learning disability (HP:0001328)2.31136433
68Fat malabsorption (HP:0002630)2.28419691
69Abnormality of methionine metabolism (HP:0010901)2.28005245
70Spastic paraparesis (HP:0002313)2.27526509
71Action tremor (HP:0002345)2.27049370
72Furrowed tongue (HP:0000221)2.23678728
73Conjugated hyperbilirubinemia (HP:0002908)2.22532884
74Split foot (HP:0001839)2.22387353
75Ketosis (HP:0001946)2.21993864
76Focal seizures (HP:0007359)2.21952739
77Poor coordination (HP:0002370)2.20779673
78Amyotrophic lateral sclerosis (HP:0007354)2.20177895
79Abnormal eating behavior (HP:0100738)2.19555354
80Hyperglycemia (HP:0003074)2.19532568
81Ketoacidosis (HP:0001993)2.18651481
82Postural instability (HP:0002172)2.15639682
83Morphological abnormality of the pyramidal tract (HP:0002062)2.14205895
84Clonus (HP:0002169)2.12967517
85Hemiparesis (HP:0001269)2.12557951
86Papilledema (HP:0001085)2.12211376
87Amyloidosis (HP:0011034)2.12069711
88Poor speech (HP:0002465)2.08855496
89Acanthocytosis (HP:0001927)2.08543659
90Prolonged partial thromboplastin time (HP:0003645)2.08294940
91Alacrima (HP:0000522)2.08159880
92Progressive neurologic deterioration (HP:0002344)2.07925876
93Hypomagnesemia (HP:0002917)2.07603503
94Generalized myoclonic seizures (HP:0002123)2.07118576
95Abnormality of the renal medulla (HP:0100957)2.05704766
96Thyroid carcinoma (HP:0002890)2.05026041
97Akinesia (HP:0002304)2.03640583
98Symptomatic seizures (HP:0011145)2.03097372
99Pheochromocytoma (HP:0002666)2.01935018
100Generalized tonic-clonic seizures (HP:0002069)2.01284064
101Bile duct proliferation (HP:0001408)1.99330084
102Abnormal biliary tract physiology (HP:0012439)1.99330084
103Scanning speech (HP:0002168)1.99237791
104Insulin-resistant diabetes mellitus (HP:0000831)1.98406498
105Lower limb muscle weakness (HP:0007340)1.97131730
106Sensorimotor neuropathy (HP:0007141)1.96466273
107Frequent falls (HP:0002359)1.95256198
108Abnormality of aspartate family amino acid metabolism (HP:0010899)1.94870826
109Abnormality of the pancreatic islet cells (HP:0006476)1.94230898
110Abnormality of endocrine pancreas physiology (HP:0012093)1.94230898
111Cerebral hypomyelination (HP:0006808)1.93765610
112Agitation (HP:0000713)1.92678549
113Clumsiness (HP:0002312)1.92012819
114Delusions (HP:0000746)1.91904409
115Broad foot (HP:0001769)1.91826944
116Choreoathetosis (HP:0001266)1.91804695
117Axonal loss (HP:0003447)1.91459754
118Hammertoe (HP:0001765)1.91114038
119Torticollis (HP:0000473)1.90931703
120Megalencephaly (HP:0001355)1.90707184
121Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.90132075
122Abnormality of the common coagulation pathway (HP:0010990)1.89958375
123Oligodactyly (hands) (HP:0001180)1.89950222
124Fetal akinesia sequence (HP:0001989)1.89877408
125Choroideremia (HP:0001139)1.89425089
126Blue irides (HP:0000635)1.89410664
127Drooling (HP:0002307)1.88615429
128Excessive salivation (HP:0003781)1.88615429
129Postaxial hand polydactyly (HP:0001162)1.86965558
130CNS hypomyelination (HP:0003429)1.86932293
131Nemaline bodies (HP:0003798)1.86446207
132Dialeptic seizures (HP:0011146)1.86137852
133Pancreatic islet-cell hyperplasia (HP:0004510)1.84851442
134Decreased motor nerve conduction velocity (HP:0003431)1.84087779
135Conjunctival hamartoma (HP:0100780)1.83152184
136Steatorrhea (HP:0002570)1.82839332
137Posterior subcapsular cataract (HP:0007787)1.81787359
138Male pseudohermaphroditism (HP:0000037)1.80115649
139Hyperventilation (HP:0002883)1.79962707
140Dyskinesia (HP:0100660)1.79661195
141Urinary bladder sphincter dysfunction (HP:0002839)1.79625874
142Hypobetalipoproteinemia (HP:0003563)1.78577687
143Difficulty running (HP:0009046)1.78145051
144Abnormality of macular pigmentation (HP:0008002)1.77985015
145Epileptic encephalopathy (HP:0200134)1.77711731
146Focal motor seizures (HP:0011153)1.76940209
147Sclerocornea (HP:0000647)1.76827354
148Male infertility (HP:0003251)1.76755095
149Aplasia/Hypoplasia of the tongue (HP:0010295)1.75974703
150Abnormality of the intrinsic pathway (HP:0010989)1.75963021
151Abnormality of monocarboxylic acid metabolism (HP:0010996)1.75895077
152Methylmalonic acidemia (HP:0002912)1.75695411
153Dysostosis multiplex (HP:0000943)1.75601148
154Broad-based gait (HP:0002136)1.75067875
155Widely spaced teeth (HP:0000687)1.74407395
156Muscle fiber inclusion bodies (HP:0100299)1.73304555
157Cystic liver disease (HP:0006706)1.73071355
158Neoplasm of the peripheral nervous system (HP:0100007)1.72751919
159Limb dystonia (HP:0002451)1.72375270
160Absence seizures (HP:0002121)1.72221232
161Mutism (HP:0002300)1.71521203
162Neuronal loss in central nervous system (HP:0002529)1.70632154
163Aplasia/Hypoplasia of the lens (HP:0008063)1.70506673
164Anxiety (HP:0000739)1.70177450
165Neuroendocrine neoplasm (HP:0100634)1.70087476
166Facial diplegia (HP:0001349)1.69867198
167Postaxial foot polydactyly (HP:0001830)1.68144501
168Increased circulating renin level (HP:0000848)1.67639591
169Abnormal drinking behavior (HP:0030082)1.66532291
170Polydipsia (HP:0001959)1.66532291
171Confusion (HP:0001289)1.66503347
172Hypokalemic alkalosis (HP:0001949)1.66497845
173Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.66197539
174Aplasia involving bones of the upper limbs (HP:0009823)1.66037983
175Aplasia of the phalanges of the hand (HP:0009802)1.66037983
176Aplasia involving bones of the extremities (HP:0009825)1.66037983
177Spontaneous abortion (HP:0005268)1.65770820
178Distal sensory impairment (HP:0002936)1.65098474
179Abnormality of salivation (HP:0100755)1.65024706

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.02959285
2CASK3.21611222
3KSR22.93427005
4OXSR12.80878149
5ERBB42.49080905
6LATS12.43613214
7MAPKAPK52.41893366
8EPHB12.40916609
9MAP3K92.38431780
10TAOK32.29695924
11PLK22.24375010
12FGFR22.24352763
13MST42.09431796
14PRKD32.08152404
15PAK62.08145562
16PKN12.04738368
17BCR1.96474025
18NTRK11.95676642
19INSRR1.95528760
20MET1.93666471
21ERBB31.82546229
22WNK41.67585713
23SGK2231.66730427
24SGK4941.66730427
25MARK11.62185405
26MAP3K121.61143465
27SGK21.54356944
28DYRK21.53916389
29LATS21.52215211
30FRK1.52204752
31OBSCN1.49495516
32MAP3K131.47159436
33CSNK1G21.47059580
34MAP3K21.46320672
35WNK31.38868700
36MAP3K61.37178216
37KSR11.33366444
38CSNK1G31.33012187
39TRIM281.32563977
40CSNK1G11.29033003
41MUSK1.28322654
42CSNK1A1L1.25221114
43ARAF1.18149763
44MINK11.14495669
45CAMKK21.12758881
46EIF2AK31.12671828
47MARK21.08458751
48CDK191.08293568
49PBK1.04767246
50YES11.03284045
51EPHA41.02845607
52RET1.02508776
53WNK11.02223327
54MAPK151.02154975
55PAK31.02013471
56UHMK11.01938429
57CAMK2B1.01402810
58BMPR1B1.01061644
59LIMK11.00635937
60ABL21.00381825
61FER0.99708623
62PTK2B0.98995124
63MAPK130.98495995
64RAF10.97184168
65NLK0.96914996
66CAMK1G0.96741909
67PNCK0.92961151
68SGK30.92470669
69LRRK20.91960754
70PHKG20.90228573
71PHKG10.90228573
72GRK50.89791387
73CAMK1D0.89624344
74DYRK1A0.89260191
75NEK60.88607560
76HIPK20.87497812
77MAP3K40.87494950
78PDPK10.86827332
79RIPK40.84572467
80CAMK2D0.83628012
81PRKCG0.83290658
82BLK0.82729496
83FGR0.82036304
84CAMK2A0.80880948
85CDK50.75506540
86FGFR10.75374130
87CCNB10.74700125
88STK30.74224075
89NTRK20.72970844
90EIF2AK10.72757444
91CAMK2G0.72561353
92BRAF0.71729644
93TYRO30.71487995
94PRKCH0.71362221
95FES0.70410699
96NTRK30.70311597
97STK38L0.69464622
98SGK10.69074626
99PINK10.67629563
100PRKAA20.67568080
101EPHA30.66975570
102GRK10.66398802
103TRPM70.65774581
104DYRK1B0.65631252
105MAP3K10.64739500
106STK240.64129909
107MAP2K40.63003742
108MAP2K70.62895382
109PRKD10.62122676
110DMPK0.61779750
111ACVR1B0.60602727
112BMPR20.60490495
113DAPK20.60367519
114BCKDK0.59890095
115PRKCE0.58119310
116MOS0.58108829
117PIK3CG0.57829903
118PDGFRB0.57357093
119PDK10.56536415
120NEK10.52882714
121CSK0.52668330
122PRKAA10.52473946
123TEC0.52156745
124ERBB20.50991945
125PRKCQ0.49705567
126MAP4K20.48441300
127ADRBK10.48004509
128PIK3CA0.47013542
129CDK140.43343694
130ROCK20.43337680
131JAK20.42986596
132TNIK0.42937624
133ADRBK20.42884587
134MELK0.42522115
135PRKG10.42135227
136MAPK120.41820352
137TAOK10.41321300
138PRKACB0.39087259
139STK110.38640694
140SIK10.38575393
141CDK150.37567494
142PRKCZ0.37329238
143CSNK1D0.36791614
144CDK180.36344750

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.25491367
2Nicotine addiction_Homo sapiens_hsa050332.75988863
3Steroid biosynthesis_Homo sapiens_hsa001002.66265600
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.51681422
5Fatty acid elongation_Homo sapiens_hsa000622.49044018
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.44131019
7Sulfur metabolism_Homo sapiens_hsa009202.34605952
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.31135983
9Regulation of autophagy_Homo sapiens_hsa041402.25454832
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.23275077
11Histidine metabolism_Homo sapiens_hsa003402.20113583
12Vitamin B6 metabolism_Homo sapiens_hsa007502.18846259
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.18380022
14Ether lipid metabolism_Homo sapiens_hsa005652.00515366
15Butanoate metabolism_Homo sapiens_hsa006501.86465618
16Olfactory transduction_Homo sapiens_hsa047401.63014189
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58480568
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.55788493
19Long-term potentiation_Homo sapiens_hsa047201.52045086
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.51819586
21Linoleic acid metabolism_Homo sapiens_hsa005911.51575133
22Arginine biosynthesis_Homo sapiens_hsa002201.50754728
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48075895
24Collecting duct acid secretion_Homo sapiens_hsa049661.43688637
25Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.35666469
26Oxidative phosphorylation_Homo sapiens_hsa001901.35298695
27Tryptophan metabolism_Homo sapiens_hsa003801.29939536
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26763588
29Fatty acid metabolism_Homo sapiens_hsa012121.22055922
30Complement and coagulation cascades_Homo sapiens_hsa046101.21222744
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21033597
32Parkinsons disease_Homo sapiens_hsa050121.20237416
33Ovarian steroidogenesis_Homo sapiens_hsa049131.15725977
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14302077
35Alzheimers disease_Homo sapiens_hsa050101.12616942
36Peroxisome_Homo sapiens_hsa041461.12080066
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11701003
38Propanoate metabolism_Homo sapiens_hsa006401.09816334
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.07651805
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07545192
41Fatty acid degradation_Homo sapiens_hsa000711.07032162
42Folate biosynthesis_Homo sapiens_hsa007901.05998275
43Protein export_Homo sapiens_hsa030601.04066826
44Renal cell carcinoma_Homo sapiens_hsa052111.02144784
45Staphylococcus aureus infection_Homo sapiens_hsa051501.01437154
46Phototransduction_Homo sapiens_hsa047441.01360653
47Oxytocin signaling pathway_Homo sapiens_hsa049211.00178015
48Sphingolipid metabolism_Homo sapiens_hsa006000.98284735
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97755478
50PPAR signaling pathway_Homo sapiens_hsa033200.96932529
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.96678551
52Cardiac muscle contraction_Homo sapiens_hsa042600.96634448
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92609622
54Dorso-ventral axis formation_Homo sapiens_hsa043200.89001804
55Insulin secretion_Homo sapiens_hsa049110.88128937
56Bile secretion_Homo sapiens_hsa049760.87691829
57Cocaine addiction_Homo sapiens_hsa050300.87449413
58Glutamatergic synapse_Homo sapiens_hsa047240.87099893
59Arginine and proline metabolism_Homo sapiens_hsa003300.86955054
60GABAergic synapse_Homo sapiens_hsa047270.85467232
61Taste transduction_Homo sapiens_hsa047420.84553069
62Calcium signaling pathway_Homo sapiens_hsa040200.82825855
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.81327976
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.81263493
65ABC transporters_Homo sapiens_hsa020100.78134972
66beta-Alanine metabolism_Homo sapiens_hsa004100.77970605
67Type II diabetes mellitus_Homo sapiens_hsa049300.77441520
68GnRH signaling pathway_Homo sapiens_hsa049120.75960204
69Fat digestion and absorption_Homo sapiens_hsa049750.72437270
70Serotonergic synapse_Homo sapiens_hsa047260.72303760
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71798828
72Chemical carcinogenesis_Homo sapiens_hsa052040.71506927
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71087386
74Tuberculosis_Homo sapiens_hsa051520.69492248
75Caffeine metabolism_Homo sapiens_hsa002320.69156995
76Retinol metabolism_Homo sapiens_hsa008300.68396881
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67565020
78Lysosome_Homo sapiens_hsa041420.67196759
79Pancreatic secretion_Homo sapiens_hsa049720.67165127
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66493531
81Circadian rhythm_Homo sapiens_hsa047100.66426018
82Melanogenesis_Homo sapiens_hsa049160.66096890
83Glycerolipid metabolism_Homo sapiens_hsa005610.66076603
84Axon guidance_Homo sapiens_hsa043600.65662669
85Gap junction_Homo sapiens_hsa045400.65027822
86Tyrosine metabolism_Homo sapiens_hsa003500.63419343
87Phagosome_Homo sapiens_hsa041450.63305204
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63296982
89Morphine addiction_Homo sapiens_hsa050320.62535165
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62408860
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61338026
92Long-term depression_Homo sapiens_hsa047300.60302870
93Vitamin digestion and absorption_Homo sapiens_hsa049770.60124078
94Huntingtons disease_Homo sapiens_hsa050160.59754845
95Hedgehog signaling pathway_Homo sapiens_hsa043400.58811204
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.57365547
97Prion diseases_Homo sapiens_hsa050200.56705646
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56572108
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.54539373
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.54377314
101Fatty acid biosynthesis_Homo sapiens_hsa000610.54148429
102Estrogen signaling pathway_Homo sapiens_hsa049150.54066847
103Selenocompound metabolism_Homo sapiens_hsa004500.53951157
104FoxO signaling pathway_Homo sapiens_hsa040680.53600495
105Inositol phosphate metabolism_Homo sapiens_hsa005620.53410824
106Circadian entrainment_Homo sapiens_hsa047130.53305266
107Cholinergic synapse_Homo sapiens_hsa047250.52421206
108Choline metabolism in cancer_Homo sapiens_hsa052310.49666126
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48888044
110Dopaminergic synapse_Homo sapiens_hsa047280.48727963
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48416390
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48187971
113Legionellosis_Homo sapiens_hsa051340.47988050
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47359250
115ErbB signaling pathway_Homo sapiens_hsa040120.47102805
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46776298
117Ras signaling pathway_Homo sapiens_hsa040140.46431864
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.45186144
119Salivary secretion_Homo sapiens_hsa049700.44152599
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43946511
121Tight junction_Homo sapiens_hsa045300.43763167
122cAMP signaling pathway_Homo sapiens_hsa040240.43717449
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43480284
124Pyruvate metabolism_Homo sapiens_hsa006200.42298960
125Pancreatic cancer_Homo sapiens_hsa052120.40082351
126Endocytosis_Homo sapiens_hsa041440.39806801
127Amphetamine addiction_Homo sapiens_hsa050310.39407924
128Renin secretion_Homo sapiens_hsa049240.38822192
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37687487
130Mineral absorption_Homo sapiens_hsa049780.34994318
131Starch and sucrose metabolism_Homo sapiens_hsa005000.34588547
132Arachidonic acid metabolism_Homo sapiens_hsa005900.32785136
133Vibrio cholerae infection_Homo sapiens_hsa051100.32452524
134Synaptic vesicle cycle_Homo sapiens_hsa047210.31741635
135Phenylalanine metabolism_Homo sapiens_hsa003600.31462677
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31073527
137Gastric acid secretion_Homo sapiens_hsa049710.31018705
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30588062
139Thyroid hormone synthesis_Homo sapiens_hsa049180.30417370

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