RNF144A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of RING finger domain-containing E3 ubiquitin ligases that also includes parkin and parc. The expression of this gene is induced by DNA damage. The encoded protein interacts with the cytoplasmic DNA-dependent protein kinase, catalytic subunit (DNA-PKcs) and promotes its degradation through ubiquitination. The orthologous mouse protein has been shown to interact with a ubiquitin-conjugating enzyme involved in embryonic development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.06320979
2postsynaptic membrane organization (GO:0001941)4.85325104
3blood vessel maturation (GO:0001955)4.65257365
4presynaptic membrane organization (GO:0097090)4.58713609
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.54964782
6membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.53493908
7regulation of synaptic vesicle exocytosis (GO:2000300)4.30975863
8synaptic vesicle docking involved in exocytosis (GO:0016081)4.28112736
9glomerular filtration (GO:0003094)4.09100552
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.07756396
11cerebellar granule cell differentiation (GO:0021707)4.06643518
12synaptic vesicle exocytosis (GO:0016079)4.04763742
13ionotropic glutamate receptor signaling pathway (GO:0035235)3.98425239
14vocalization behavior (GO:0071625)3.97360415
15glutamate secretion (GO:0014047)3.95488707
16neurotransmitter-gated ion channel clustering (GO:0072578)3.91802792
17lateral sprouting from an epithelium (GO:0060601)3.88272889
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.87021344
19cell migration in hindbrain (GO:0021535)3.76636818
20exploration behavior (GO:0035640)3.74627962
21protein localization to synapse (GO:0035418)3.71468386
22cerebellar Purkinje cell differentiation (GO:0021702)3.70615121
23auditory behavior (GO:0031223)3.69930065
24regulation of synaptic vesicle transport (GO:1902803)3.61594234
25locomotory exploration behavior (GO:0035641)3.53542024
26cellular potassium ion homeostasis (GO:0030007)3.52260341
27positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.51253939
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.47067571
29renal filtration (GO:0097205)3.46213416
30regulation of glutamate receptor signaling pathway (GO:1900449)3.45310930
31establishment of mitochondrion localization (GO:0051654)3.43514638
32positive regulation of synapse maturation (GO:0090129)3.37895589
33positive regulation of dendritic spine morphogenesis (GO:0061003)3.37676797
34pyrimidine nucleobase catabolic process (GO:0006208)3.35564442
35neuron recognition (GO:0008038)3.35132329
36regulation of neuronal synaptic plasticity (GO:0048168)3.34514104
37neurotransmitter secretion (GO:0007269)3.32498346
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.31828300
39synaptic transmission, glutamatergic (GO:0035249)3.30358336
40neuronal action potential propagation (GO:0019227)3.26478157
41L-amino acid import (GO:0043092)3.26146906
42sodium ion export (GO:0071436)3.24165294
43cell differentiation in hindbrain (GO:0021533)3.23761611
44dermatan sulfate biosynthetic process (GO:0030208)3.22061522
45regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.19903893
46mechanosensory behavior (GO:0007638)3.19833524
47dermatan sulfate metabolic process (GO:0030205)3.18941120
48endothelial tube morphogenesis (GO:0061154)3.18441975
49morphogenesis of an endothelium (GO:0003159)3.18441975
50regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.18175733
51neuronal ion channel clustering (GO:0045161)3.15514557
52regulation of axon extension involved in axon guidance (GO:0048841)3.13117433
53positive regulation of dendritic spine development (GO:0060999)3.11784780
54glutamate receptor signaling pathway (GO:0007215)3.08747654
55cell communication by electrical coupling (GO:0010644)3.06090766
56regulation of long-term neuronal synaptic plasticity (GO:0048169)3.05892739
57transmission of nerve impulse (GO:0019226)3.04259321
58negative regulation of axon extension involved in axon guidance (GO:0048843)3.03999776
59regulation of dendritic spine morphogenesis (GO:0061001)3.01801326
60cell proliferation involved in metanephros development (GO:0072203)3.01106292
61neuromuscular process controlling balance (GO:0050885)3.00911340
62establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.98979813
63mitochondrion transport along microtubule (GO:0047497)2.98979813
64lymphangiogenesis (GO:0001946)2.98303516
65potassium ion import (GO:0010107)2.96625191
66regulation of synapse maturation (GO:0090128)2.95999618
67response to auditory stimulus (GO:0010996)2.95544797
68cellular response to monoamine stimulus (GO:0071868)2.94669468
69cellular response to catecholamine stimulus (GO:0071870)2.94669468
70regulation of ARF protein signal transduction (GO:0032012)2.94039523
71positive regulation of membrane potential (GO:0045838)2.93669987
72regulation of axon guidance (GO:1902667)2.92102394
73gonadal mesoderm development (GO:0007506)2.91900401
74regulation of synapse structural plasticity (GO:0051823)2.91307697
75neuron-neuron synaptic transmission (GO:0007270)2.89357612
76regulation of excitatory postsynaptic membrane potential (GO:0060079)2.88947214
77membrane depolarization during action potential (GO:0086010)2.88905074
78negative regulation of dendrite morphogenesis (GO:0050774)2.87530796
79layer formation in cerebral cortex (GO:0021819)2.84077652
80negative regulation of catenin import into nucleus (GO:0035414)2.83275878
81negative regulation of axon extension (GO:0030517)2.82722812
82negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.81411844
83artery development (GO:0060840)2.80347165
84peptidyl-tyrosine autophosphorylation (GO:0038083)2.79581806
85cell proliferation involved in kidney development (GO:0072111)2.78975293
86positive regulation of vasculogenesis (GO:2001214)2.78324243
87cellular sodium ion homeostasis (GO:0006883)2.78021687
88regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.77915326
89positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.77682964
90synapse assembly (GO:0007416)2.75419410
91positive regulation of synapse assembly (GO:0051965)2.75209527
92regulation of postsynaptic membrane potential (GO:0060078)2.75077498
93establishment of nucleus localization (GO:0040023)2.74820866
94regulation of vesicle fusion (GO:0031338)2.73317915
95negative regulation of axon guidance (GO:1902668)2.73179744
96enteric nervous system development (GO:0048484)2.72866433
97regulation of dendrite morphogenesis (GO:0048814)2.72716704
98regulation of vasculogenesis (GO:2001212)2.71987017
99respiratory tube development (GO:0030323)2.70730819
100neurotransmitter transport (GO:0006836)2.70100640
101regulation of neurotransmitter secretion (GO:0046928)2.69675730
102lymph vessel development (GO:0001945)2.69245878
103regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.67142710
104regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.66920980
105negative regulation of vascular permeability (GO:0043116)2.63871569
106endothelial cell differentiation (GO:0045446)2.63462034
107dendritic spine organization (GO:0097061)2.63246290
108regulation of synaptic transmission, glutamatergic (GO:0051966)2.62549931
109somite development (GO:0061053)2.61234607
110planar cell polarity pathway involved in neural tube closure (GO:0090179)2.60942984
111membrane depolarization (GO:0051899)2.60624505
112regulation of endothelial cell differentiation (GO:0045601)2.60326407
113glucocorticoid receptor signaling pathway (GO:0042921)2.59837532
114negative regulation of dendrite development (GO:2000171)2.59366135
115vascular endothelial growth factor signaling pathway (GO:0038084)2.59343532
116response to catecholamine (GO:0071869)2.58760366
117response to monoamine (GO:0071867)2.58760366
118long-term memory (GO:0007616)2.58513365
119regulation of respiratory gaseous exchange (GO:0043576)2.58362186
120synaptic vesicle endocytosis (GO:0048488)2.58155436
121potassium ion homeostasis (GO:0055075)2.58068449
122positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.56622730
123endocardial cushion morphogenesis (GO:0003203)2.55968107
124chondrocyte development (GO:0002063)2.55951467
125negative regulation of cytosolic calcium ion concentration (GO:0051481)2.55822053
126negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.55338457
127limb bud formation (GO:0060174)2.54767823
128positive regulation of dendrite development (GO:1900006)2.54397493
129regulation of dendritic spine development (GO:0060998)2.53404053
130cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.52992081
131dendrite morphogenesis (GO:0048813)2.52507558
132head development (GO:0060322)2.51944967
133regulation of somitogenesis (GO:0014807)2.51251231
134myelination in peripheral nervous system (GO:0022011)2.51180351
135peripheral nervous system axon ensheathment (GO:0032292)2.51180351
136camera-type eye morphogenesis (GO:0048593)2.47755004
137neuron cell-cell adhesion (GO:0007158)2.45918454
138photoreceptor cell differentiation (GO:0046530)2.43525331
139eye photoreceptor cell differentiation (GO:0001754)2.43525331
140central nervous system myelination (GO:0022010)2.43183765
141axon ensheathment in central nervous system (GO:0032291)2.43183765
142definitive hemopoiesis (GO:0060216)2.42913870
143hindlimb morphogenesis (GO:0035137)2.42085005
144myelination (GO:0042552)2.41803008
145proximal/distal pattern formation (GO:0009954)2.41302698
146positive regulation of endothelial cell differentiation (GO:0045603)2.38477205
147astrocyte development (GO:0014002)2.38413924
148dendritic spine morphogenesis (GO:0060997)2.37755069
149mitotic sister chromatid cohesion (GO:0007064)2.37369480
150embryonic hindlimb morphogenesis (GO:0035116)2.35765320
151ensheathment of neurons (GO:0007272)2.34569881
152axon ensheathment (GO:0008366)2.34569881
153hippo signaling (GO:0035329)2.33363991
154negative regulation of axonogenesis (GO:0050771)2.32976631
155neuron projection extension involved in neuron projection guidance (GO:1902284)2.31938942
156axon extension involved in axon guidance (GO:0048846)2.31938942
157regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.31097571
158positive regulation of lipid kinase activity (GO:0090218)2.30969215
159mesenchyme morphogenesis (GO:0072132)2.30958600
160activated T cell proliferation (GO:0050798)2.29349161
161mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.29030771
162negative regulation of developmental growth (GO:0048640)2.29001741
163regulation of non-canonical Wnt signaling pathway (GO:2000050)2.27990356
164regulation of establishment of planar polarity (GO:0090175)2.27596255
165presynaptic membrane assembly (GO:0097105)2.24741655
166bone trabecula formation (GO:0060346)2.24418098
167anatomical structure regression (GO:0060033)2.24030357
168positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.23327956
169regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.22994308
170Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.22135215
171positive regulation of chondrocyte differentiation (GO:0032332)2.21148552
172myelin maintenance (GO:0043217)2.20919723
173axonal fasciculation (GO:0007413)2.20914777
174cortical actin cytoskeleton organization (GO:0030866)2.20248879
175cell migration involved in heart development (GO:0060973)2.19798103
176nerve growth factor signaling pathway (GO:0038180)2.19622987
177glial cell proliferation (GO:0014009)2.19118486
178positive regulation of dendrite morphogenesis (GO:0050775)2.17993961
179glomerular basement membrane development (GO:0032836)2.17307490
180central nervous system projection neuron axonogenesis (GO:0021952)2.16991233
181asymmetric protein localization (GO:0008105)2.16594854
182radial glial cell differentiation (GO:0060019)2.15839586
183positive regulation of cartilage development (GO:0061036)2.15124859
184prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.15040360
185somatic stem cell division (GO:0048103)2.13331278
186positive regulation of oligodendrocyte differentiation (GO:0048714)2.13282071
187glomerulus development (GO:0032835)2.12877750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.87896516
2EZH2_22144423_ChIP-Seq_EOC_Human3.39217552
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.22323457
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.81897233
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60780401
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60780401
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.58259871
8EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.48018511
9REST_21632747_ChIP-Seq_MESCs_Mouse2.44572919
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.42218185
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42133813
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.40932493
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31447988
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30725534
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29243834
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28234650
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.23328570
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19960341
19WT1_19549856_ChIP-ChIP_CCG9911_Human2.16784232
20WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.15712341
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09172435
22AR_21572438_ChIP-Seq_LNCaP_Human2.06458280
23PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.02964034
24* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00977293
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97634994
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.97167441
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.89573927
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.85790841
29* DROSHA_22980978_ChIP-Seq_HELA_Human1.77234193
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.76885779
31GBX2_23144817_ChIP-Seq_PC3_Human1.74566237
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73665191
33* EZH2_27294783_Chip-Seq_ESCs_Mouse1.72569713
34* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.71680965
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68761717
36RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.63843456
37* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.63513180
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62973904
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.62299012
40DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.61373355
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.60467721
42SCL_19346495_ChIP-Seq_HPC-7_Human1.57687489
43* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56616794
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.56169007
45* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54275605
46WT1_25993318_ChIP-Seq_PODOCYTE_Human1.53247698
47RNF2_27304074_Chip-Seq_NSC_Mouse1.47386707
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47177383
49RING1B_27294783_Chip-Seq_NPCs_Mouse1.44307224
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44009079
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43727386
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38890127
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38347973
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.38013885
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36773460
56TRIM28_21343339_ChIP-Seq_HEK293_Human1.35631323
57* KDM2B_26808549_Chip-Seq_JURKAT_Human1.34103327
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.33674452
59RUNX_20019798_ChIP-Seq_JUKART_Human1.33305062
60* KDM2B_26808549_Chip-Seq_DND41_Human1.32001706
61KDM2B_26808549_Chip-Seq_K562_Human1.31057114
62ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30782564
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29976442
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.28994215
65* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28521629
66* SMAD4_21799915_ChIP-Seq_A2780_Human1.27447846
67ISL1_27105846_Chip-Seq_CPCs_Mouse1.27233570
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27109311
69IGF1R_20145208_ChIP-Seq_DFB_Human1.26404482
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.25724560
71* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25496772
72* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25190925
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20529209
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20493538
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18520137
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15845432
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15685920
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11984037
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11984037
80ZNF274_21170338_ChIP-Seq_K562_Hela1.11869791
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10957704
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10783959
83TCF4_18268006_ChIP-ChIP_LS174T_Human1.09933962
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.09911107
85TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09530611
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08481521
87* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07354501
88AHR_22903824_ChIP-Seq_MCF-7_Human1.06778633
89OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06534666
90* PIAS1_25552417_ChIP-Seq_VCAP_Human1.05172355
91DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04016066
92* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03540862
93* TCF7_22412390_ChIP-Seq_EML_Mouse1.02712791
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02581394
95YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02418401
96BP1_19119308_ChIP-ChIP_Hs578T_Human1.02040123
97CLOCK_20551151_ChIP-Seq_293T_Human1.01310683
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01030311
99* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00977102
100TAF15_26573619_Chip-Seq_HEK293_Human1.00919141
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00575978
102RARB_27405468_Chip-Seq_BRAIN_Mouse1.00571183
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00254088
104* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00006792
105ESR1_20079471_ChIP-ChIP_T-47D_Human0.98898629
106GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98651698
107STAT3_23295773_ChIP-Seq_U87_Human0.98454353
108CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97128879
109* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96722355
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96052049
111SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95960557
112* TCF4_23295773_ChIP-Seq_U87_Human0.95251022
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95146951
114CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94704564
115SOX9_26525672_Chip-Seq_HEART_Mouse0.94551555
116POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94522434
117RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93398751
118POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92996812
119TP53_20018659_ChIP-ChIP_R1E_Mouse0.92618975
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92289753
121P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91863756
122KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91383588
123PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91242341
124ERG_21242973_ChIP-ChIP_JURKAT_Human0.91222621
125KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91196636
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91000822
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90671293
128* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90407954
129MYC_22102868_ChIP-Seq_BL_Human0.90096228
130VDR_24763502_ChIP-Seq_THP-1_Human0.89256672
131CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89175529
132BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89116755
133AR_19668381_ChIP-Seq_PC3_Human0.89115276
134GATA2_21666600_ChIP-Seq_HMVEC_Human0.88924399
135* SMAD3_21741376_ChIP-Seq_EPCs_Human0.88610883
136FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87714607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia3.39921727
2MP0005503_abnormal_tendon_morphology3.13714734
3MP0010368_abnormal_lymphatic_system2.78042977
4MP0001958_emphysema2.72638792
5MP0002064_seizures2.68775161
6MP0002063_abnormal_learning/memory/cond2.66352308
7MP0002822_catalepsy2.46508298
8MP0008438_abnormal_cutaneous_collagen2.40134708
9MP0001879_abnormal_lymphatic_vessel2.33280267
10MP0009745_abnormal_behavioral_response2.33256650
11MP0009278_abnormal_bone_marrow2.32829406
12MP0000537_abnormal_urethra_morphology2.31190297
13MP0004272_abnormal_basement_membrane2.28836100
14MP0005167_abnormal_blood-brain_barrier2.25132153
15MP0002272_abnormal_nervous_system2.21102009
16MP0008569_lethality_at_weaning2.19436670
17MP0002938_white_spotting2.16297093
18MP0003385_abnormal_body_wall2.13840887
19MP0002734_abnormal_mechanical_nocicepti2.13286094
20MP0009046_muscle_twitch2.10198666
21MP0002572_abnormal_emotion/affect_behav2.06637214
22MP0003279_aneurysm2.03122191
23MP0009250_abnormal_appendicular_skeleto2.00008027
24MP0002282_abnormal_trachea_morphology1.97403069
25MP0004134_abnormal_chest_morphology1.96780045
26MP0002638_abnormal_pupillary_reflex1.87912634
27MP0003122_maternal_imprinting1.77480460
28MP0004811_abnormal_neuron_physiology1.75876245
29MP0002735_abnormal_chemical_nociception1.74366729
30MP0000778_abnormal_nervous_system1.71186454
31MP0002396_abnormal_hematopoietic_system1.68490567
32MP0002067_abnormal_sensory_capabilities1.66213013
33MP0002184_abnormal_innervation1.65193927
34MP0005423_abnormal_somatic_nervous1.59930568
35MP0003942_abnormal_urinary_system1.57969961
36MP0001502_abnormal_circadian_rhythm1.57947970
37MP0005187_abnormal_penis_morphology1.57082051
38MP0003690_abnormal_glial_cell1.55950419
39MP0002882_abnormal_neuron_morphology1.55063263
40MP0000534_abnormal_ureter_morphology1.54929498
41MP0005171_absent_coat_pigmentation1.52689782
42MP0005409_darkened_coat_color1.51675216
43MP0001970_abnormal_pain_threshold1.50342801
44MP0001501_abnormal_sleep_pattern1.49716114
45MP0002557_abnormal_social/conspecific_i1.49607757
46MP0003121_genomic_imprinting1.46146655
47MP0004885_abnormal_endolymph1.45471999
48MP0002932_abnormal_joint_morphology1.45463063
49MP0001984_abnormal_olfaction1.45164142
50MP0006276_abnormal_autonomic_nervous1.44164965
51MP0003633_abnormal_nervous_system1.44063672
52MP0000465_gastrointestinal_hemorrhage1.43361759
53MP0000049_abnormal_middle_ear1.41617622
54MP0002733_abnormal_thermal_nociception1.40551827
55MP0001270_distended_abdomen1.38505424
56MP0004859_abnormal_synaptic_plasticity1.37267058
57MP0003329_amyloid_beta_deposits1.37131256
58MP0004808_abnormal_hematopoietic_stem1.35066962
59MP0006054_spinal_hemorrhage1.34807395
60MP0000920_abnormal_myelination1.34784523
61MP0005623_abnormal_meninges_morphology1.34656051
62MP0002249_abnormal_larynx_morphology1.34059782
63MP0003937_abnormal_limbs/digits/tail_de1.33992915
64MP0003935_abnormal_craniofacial_develop1.33292112
65MP0003115_abnormal_respiratory_system1.32382498
66MP0004858_abnormal_nervous_system1.31528077
67MP0003631_nervous_system_phenotype1.29800306
68MP0002066_abnormal_motor_capabilities/c1.28943183
69MP0004924_abnormal_behavior1.27090519
70MP0005386_behavior/neurological_phenoty1.27090519
71MP0002009_preneoplasia1.26944142
72MP0000428_abnormal_craniofacial_morphol1.26360176
73MP0000767_abnormal_smooth_muscle1.25353427
74MP0010030_abnormal_orbit_morphology1.24971030
75MP0003136_yellow_coat_color1.22375521
76MP0002133_abnormal_respiratory_system1.21276276
77MP0005388_respiratory_system_phenotype1.21276276
78MP0001299_abnormal_eye_distance/1.21248649
79MP0002089_abnormal_postnatal_growth/wei1.20489463
80MP0002736_abnormal_nociception_after1.18888838
81MP0003632_abnormal_nervous_system1.18667165
82MP0001485_abnormal_pinna_reflex1.16013537
83MP0002116_abnormal_craniofacial_bone1.15063106
84MP0003634_abnormal_glial_cell1.14785996
85MP0002108_abnormal_muscle_morphology1.13268942
86MP0002751_abnormal_autonomic_nervous1.09929543
87MP0008877_abnormal_DNA_methylation1.08798451
88MP0003828_pulmonary_edema1.08009766
89MP0002925_abnormal_cardiovascular_devel1.07956625
90MP0001177_atelectasis1.07266040
91MP0002752_abnormal_somatic_nervous1.06881426
92MP0001440_abnormal_grooming_behavior1.04675774
93MP0004883_abnormal_blood_vessel1.03714353
94MP0005508_abnormal_skeleton_morphology1.03614175
95MP0001963_abnormal_hearing_physiology1.02648004
96MP0000569_abnormal_digit_pigmentation1.01221373
97MP0001661_extended_life_span1.00317355
98MP0000631_abnormal_neuroendocrine_gland0.99957122
99MP0000733_abnormal_muscle_development0.99267579
100MP0003787_abnormal_imprinting0.98859601
101MP0003861_abnormal_nervous_system0.96877838
102MP0001188_hyperpigmentation0.96711859
103MP0001486_abnormal_startle_reflex0.96596357
104MP0004142_abnormal_muscle_tone0.96159920
105MP0002109_abnormal_limb_morphology0.95890876
106MP0008995_early_reproductive_senescence0.95853649
107MP0005595_abnormal_vascular_smooth0.95786074
108MP0004742_abnormal_vestibular_system0.95006008
109MP0009053_abnormal_anal_canal0.94670800
110MP0003938_abnormal_ear_development0.94613109
111MP0003567_abnormal_fetal_cardiomyocyte0.94589289
112MP0000751_myopathy0.94445130
113MP0008961_abnormal_basal_metabolism0.93689142
114MP0009384_cardiac_valve_regurgitation0.93573599
115MP0005646_abnormal_pituitary_gland0.93341362
116MP0000163_abnormal_cartilage_morphology0.89678645
117MP0001986_abnormal_taste_sensitivity0.89351663
118MP0001968_abnormal_touch/_nociception0.89320171
119MP0003635_abnormal_synaptic_transmissio0.88993189
120MP0001346_abnormal_lacrimal_gland0.88798386
121MP0000026_abnormal_inner_ear0.87467184
122MP0004130_abnormal_muscle_cell0.86879203
123MP0002128_abnormal_blood_circulation0.86575949
124MP0002233_abnormal_nose_morphology0.86373894
125MP0001293_anophthalmia0.85530694
126MP0001943_abnormal_respiration0.85308314
127MP0002115_abnormal_skeleton_extremities0.85011909
128MP0003755_abnormal_palate_morphology0.83904394
129MP0003880_abnormal_central_pattern0.82195749
130MP0003123_paternal_imprinting0.82170342
131MP0001175_abnormal_lung_morphology0.81881954
132MP0003091_abnormal_cell_migration0.81795238
133MP0006138_congestive_heart_failure0.81199236
134MP0010769_abnormal_survival0.79465220
135MP0003300_gastrointestinal_ulcer0.79004296
136MP0005248_abnormal_Harderian_gland0.78957850
137MP0000343_altered_response_to0.78697101
138MP0000462_abnormal_digestive_system0.78591284
139MP0002114_abnormal_axial_skeleton0.78432461
140MP0002229_neurodegeneration0.78210005
141MP0001614_abnormal_blood_vessel0.77728200
142MP0002082_postnatal_lethality0.77348270
143MP0010770_preweaning_lethality0.77348270
144MP0002152_abnormal_brain_morphology0.77164676
145MP0005253_abnormal_eye_physiology0.76778273
146MP0002113_abnormal_skeleton_development0.76470029
147MP0000566_synostosis0.74815088
148MP0010768_mortality/aging0.74775165
149MP0002081_perinatal_lethality0.74432210
150MP0001529_abnormal_vocalization0.73028057
151MP0003890_abnormal_embryonic-extraembry0.72595791
152MP0000955_abnormal_spinal_cord0.72558406
153MP0009780_abnormal_chondrocyte_physiolo0.72148327
154MP0001545_abnormal_hematopoietic_system0.71027931
155MP0005397_hematopoietic_system_phenotyp0.71027931
156MP0005551_abnormal_eye_electrophysiolog0.71025667
157MP0005275_abnormal_skin_tensile0.70861699
158MP0003283_abnormal_digestive_organ0.69500612
159MP0005377_hearing/vestibular/ear_phenot0.68285334
160MP0003878_abnormal_ear_physiology0.68285334
161MP0003119_abnormal_digestive_system0.67990171
162MP0005499_abnormal_olfactory_system0.67774976
163MP0005394_taste/olfaction_phenotype0.67774976
164MP0002909_abnormal_adrenal_gland0.66185658
165MP0005645_abnormal_hypothalamus_physiol0.65330698
166MP0002069_abnormal_eating/drinking_beha0.63703531

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)5.06124233
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.06124233
3Focal motor seizures (HP:0011153)5.05331330
4Myokymia (HP:0002411)4.29772333
5Focal seizures (HP:0007359)4.13578528
6Abnormality of the 4th metacarpal (HP:0010012)4.04116246
7Febrile seizures (HP:0002373)3.66396134
8Broad metatarsal (HP:0001783)3.45651101
9Midline defect of the nose (HP:0004122)3.44344894
10Action tremor (HP:0002345)3.41252719
11Epileptic encephalopathy (HP:0200134)3.08261616
12Trigonocephaly (HP:0000243)3.07037650
13Atonic seizures (HP:0010819)3.03903643
14Renal duplication (HP:0000075)3.02590918
15Hemiplegia (HP:0002301)2.96553508
16Peripheral hypomyelination (HP:0007182)2.93275644
17Overriding aorta (HP:0002623)2.90897482
18Ankle clonus (HP:0011448)2.84944495
19Shallow orbits (HP:0000586)2.84773489
20Spontaneous hematomas (HP:0007420)2.83962586
21Abnormality of the diencephalon (HP:0010662)2.82695772
22Annular pancreas (HP:0001734)2.80634223
23Progressive cerebellar ataxia (HP:0002073)2.79995748
24Abnormality of the corticospinal tract (HP:0002492)2.75694783
25Hyperacusis (HP:0010780)2.69917759
26Abnormality of the parietal bone (HP:0002696)2.69642068
27Spastic gait (HP:0002064)2.69595468
28Amblyopia (HP:0000646)2.67108919
29Obstructive sleep apnea (HP:0002870)2.63557412
30Limb dystonia (HP:0002451)2.63484853
31Drooling (HP:0002307)2.56363640
32Abnormality of binocular vision (HP:0011514)2.52843881
33Diplopia (HP:0000651)2.52843881
34Elfin facies (HP:0004428)2.50192798
35Hematochezia (HP:0002573)2.49821543
36Hyperventilation (HP:0002883)2.49287835
37Supranuclear gaze palsy (HP:0000605)2.49067944
38Renovascular hypertension (HP:0100817)2.46597477
39Generalized tonic-clonic seizures (HP:0002069)2.45211780
40Blue irides (HP:0000635)2.44995162
41Excessive salivation (HP:0003781)2.44607534
42Flat cornea (HP:0007720)2.43168536
43Hemiparesis (HP:0001269)2.42502375
44Asymmetry of the thorax (HP:0001555)2.41688059
45Truncal ataxia (HP:0002078)2.41382973
46Bladder diverticulum (HP:0000015)2.40348810
47Broad ribs (HP:0000885)2.39223257
48Genetic anticipation (HP:0003743)2.36211789
49Urinary bladder sphincter dysfunction (HP:0002839)2.34463556
50Abnormality of the lower motor neuron (HP:0002366)2.33650182
51Degeneration of the lateral corticospinal tracts (HP:0002314)2.29052829
52Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.29052829
53Broad-based gait (HP:0002136)2.27956761
54Abnormal eating behavior (HP:0100738)2.27767198
55Papilledema (HP:0001085)2.26016491
56Scanning speech (HP:0002168)2.19021761
57Thickened helices (HP:0000391)2.15324524
58Coronal craniosynostosis (HP:0004440)2.13271687
59Impaired vibration sensation in the lower limbs (HP:0002166)2.12831658
60Neurofibrillary tangles (HP:0002185)2.12237414
61Dialeptic seizures (HP:0011146)2.11719484
62Increased nuchal translucency (HP:0010880)2.11518368
63Sleep apnea (HP:0010535)2.10241389
64Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.09244620
65Volvulus (HP:0002580)2.07879761
66Absence seizures (HP:0002121)2.07421697
67Synostosis involving the elbow (HP:0003938)2.06928943
68Humeroradial synostosis (HP:0003041)2.06928943
69Sacral dimple (HP:0000960)2.05333611
70Large earlobe (HP:0009748)2.05138880
71Narrow palate (HP:0000189)2.04178830
72Insomnia (HP:0100785)2.04034336
73Visual hallucinations (HP:0002367)2.03518535
74Heterochromia iridis (HP:0001100)2.03370591
75Megalencephaly (HP:0001355)2.03302824
76Urinary urgency (HP:0000012)2.02874645
77Supernumerary ribs (HP:0005815)2.02714524
78Aqueductal stenosis (HP:0002410)2.01117737
79Broad palm (HP:0001169)2.00667327
80Protrusio acetabuli (HP:0003179)1.99705496
81Lower limb muscle weakness (HP:0007340)1.98999428
82Tracheomalacia (HP:0002779)1.96409790
83Stereotypic behavior (HP:0000733)1.96277678
84Lower limb asymmetry (HP:0100559)1.93875320
85Lymphangioma (HP:0100764)1.91841725
86Abnormality of the ischium (HP:0003174)1.91590485
87Macroorchidism (HP:0000053)1.91473303
88Absent speech (HP:0001344)1.90785686
89Postural instability (HP:0002172)1.90428961
90Deeply set eye (HP:0000490)1.88700769
91Enlarged penis (HP:0000040)1.87492532
92Mesomelia (HP:0003027)1.87477686
93Buphthalmos (HP:0000557)1.86708640
94Deviation of the hallux (HP:0010051)1.86371202
95Exotropia (HP:0000577)1.85329934
96Cerebral inclusion bodies (HP:0100314)1.85305830
97Broad phalanx (HP:0006009)1.85262623
98Abnormal social behavior (HP:0012433)1.85188416
99Impaired social interactions (HP:0000735)1.85188416
100Difficulty running (HP:0009046)1.84956830
101Broad long bones (HP:0005622)1.84818681
102Anteriorly placed anus (HP:0001545)1.84414397
103Dysdiadochokinesis (HP:0002075)1.84032429
104Bowel diverticulosis (HP:0005222)1.83464167
105Visceral angiomatosis (HP:0100761)1.82560525
106Heterotopia (HP:0002282)1.82150526
107Broad toe (HP:0001837)1.81302560
108Cutaneous finger syndactyly (HP:0010554)1.81184649
109Prolonged QT interval (HP:0001657)1.79594011
110Broad finger (HP:0001500)1.78773381
111Microglossia (HP:0000171)1.78687773
112Hallux valgus (HP:0001822)1.78359883
113Wide anterior fontanel (HP:0000260)1.78208817
114Sporadic (HP:0003745)1.77898101
115Poor eye contact (HP:0000817)1.77721171
116Broad phalanges of the hand (HP:0009768)1.77328677
117Supernumerary bones of the axial skeleton (HP:0009144)1.76870765
118Broad thumb (HP:0011304)1.76852097
119Disproportionate tall stature (HP:0001519)1.76647918
120Exostoses (HP:0100777)1.75563664
121Abnormality of the aortic arch (HP:0012303)1.75218360
122Mild short stature (HP:0003502)1.75110811
123Dysmetria (HP:0001310)1.73087664
124Pulmonary artery stenosis (HP:0004415)1.72371634
125Amyotrophic lateral sclerosis (HP:0007354)1.71542680
126Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.71026282
127Spinal cord lesions (HP:0100561)1.70872771
128Syringomyelia (HP:0003396)1.70872771
129Absent frontal sinuses (HP:0002688)1.70588983
130Mitral regurgitation (HP:0001653)1.69951165
131Epiphyseal dysplasia (HP:0002656)1.69573322
132Hypoplasia of the corpus callosum (HP:0002079)1.69389142
133Alacrima (HP:0000522)1.67665402
134Down-sloping shoulders (HP:0200021)1.67288427
135Cutaneous syndactyly (HP:0012725)1.67280155
136Hemangiomatosis (HP:0007461)1.66942504
137Hypoplastic ischia (HP:0003175)1.66692961
138Skull defect (HP:0001362)1.66362403
139Morphological abnormality of the inner ear (HP:0011390)1.65524307
140Protruding tongue (HP:0010808)1.65499576
141Ankle contracture (HP:0006466)1.64812802
142Abnormality of the sella turcica (HP:0002679)1.64715817
143Abnormal number of incisors (HP:0011064)1.64537008
144Pheochromocytoma (HP:0002666)1.64429413
145Accelerated skeletal maturation (HP:0005616)1.63895397
146Spinal canal stenosis (HP:0003416)1.62939343
147Broad hallux (HP:0010055)1.62936330
148Neoplasm of the heart (HP:0100544)1.62778214
149Hypoplasia of the maxilla (HP:0000327)1.62770932
150Morphological abnormality of the pyramidal tract (HP:0002062)1.62515283
151Status epilepticus (HP:0002133)1.62236407
152Arnold-Chiari malformation (HP:0002308)1.61448962
153Abnormal hair whorl (HP:0010721)1.60423384
154Abnormality of the distal phalanx of the thumb (HP:0009617)1.59367360
155Obsessive-compulsive behavior (HP:0000722)1.58435138
156Cerebral aneurysm (HP:0004944)1.58067614
157Broad distal phalanx of finger (HP:0009836)1.57664884
158Impaired smooth pursuit (HP:0007772)1.56780273
159Pointed chin (HP:0000307)1.56594276
160Deformed sella turcica (HP:0002681)1.56464627
161Premature skin wrinkling (HP:0100678)1.56432742
162Aplasia/Hypoplasia of the clavicles (HP:0006710)1.56052817
163Abnormality of the fingertips (HP:0001211)1.55123931
164Abnormality of the humeroradial joint (HP:0100744)1.54928842
165Autism (HP:0000717)1.54560781
166High anterior hairline (HP:0009890)1.53897425
167Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.53773206
168Germ cell neoplasia (HP:0100728)1.53202797
169Chin dimple (HP:0010751)1.53150550
170Turricephaly (HP:0000262)1.52582576
171Papillary thyroid carcinoma (HP:0002895)1.52106061
172Neoplasm of the oral cavity (HP:0100649)1.50959676
173Hepatoblastoma (HP:0002884)1.50721894
174Patellar dislocation (HP:0002999)1.50113858
175Megalocornea (HP:0000485)1.50053991
176Abnormality of the middle phalanges of the toes (HP:0010183)1.49852058
177Insidious onset (HP:0003587)1.48587233
178Termporal pattern (HP:0011008)1.48587233
179Arterial tortuosity (HP:0005116)1.47786085
180Vitreoretinal degeneration (HP:0000655)1.47539397
181Fibrous tissue neoplasm (HP:0012316)1.46940604

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.25550856
2FGFR23.06228778
3NTRK32.95588068
4TGFBR12.70944247
5ICK2.61928819
6EPHA42.54455253
7PRKD32.51894508
8EPHB12.47207470
9TYRO32.40163833
10PRPF4B2.28517429
11CAMK1G2.15604829
12TRIB32.15022872
13PAK61.93460997
14PDGFRA1.80131680
15EEF2K1.77111265
16CLK11.75894986
17FES1.64899692
18EPHB21.62294978
19TGFBR21.57734037
20TNIK1.57645589
21MARK11.55954155
22MAPK131.54573683
23ERBB31.52559928
24CAMK1D1.45966707
25NTRK21.45401569
26CSNK1A1L1.43129579
27KDR1.41550767
28MAP3K41.39161241
29PDGFRB1.38104525
30UHMK11.32015581
31PASK1.27693054
32DYRK1A1.26769010
33BMPR1B1.23969357
34EPHA31.23613765
35FGFR31.22532389
36DMPK1.21250673
37PTK61.21222881
38WNK11.19575833
39BRD41.16098864
40CASK1.15897318
41SIK21.14746612
42MKNK21.12761712
43CSNK1G31.09900620
44AKT31.05501150
45CSNK1G11.04903620
46RIPK11.04687368
47ILK1.04162632
48BTK1.01007286
49CAMKK11.00247828
50LRRK21.00102321
51CDK90.99827317
52FGFR10.97696274
53CSNK1G20.95963540
54DAPK20.95358201
55FGFR40.95163207
56NTRK10.93470727
57PHKG20.93461000
58PHKG10.93461000
59NLK0.92661113
60RET0.90361930
61DDR20.89385004
62SIK10.88430993
63ROCK20.88186949
64MAP3K70.88149819
65MAP3K100.87494102
66ALK0.86718922
67SGK4940.85747565
68SGK2230.85747565
69PAK40.84866261
70LIMK10.84518110
71SGK10.84456350
72MAP2K40.83837696
73KIT0.82744708
74PINK10.82611255
75LMTK20.82104648
76MAP3K90.80997425
77PKN20.80615007
78CAMK10.79110159
79CSK0.78919047
80PTK2B0.77867164
81SIK30.77665246
82MARK20.77477893
83DYRK1B0.76111759
84KSR20.75224449
85CSF1R0.73871147
86KSR10.73794314
87INSRR0.72841690
88PLK20.72112318
89MAPK100.69076370
90PRKCH0.65675899
91MINK10.65579208
92MAP2K70.65480933
93DYRK20.65243146
94LATS10.64818188
95PKN10.64132800
96CAMKK20.62565650
97PRKCG0.62528410
98CDK150.62029722
99ROCK10.61013100
100YES10.60746322
101SGK20.59626969
102CDK11A0.58484655
103CDK180.58042381
104SGK30.57719737
105STK390.57551175
106LATS20.57369903
107FYN0.57287046
108CDK80.57167713
109ERBB20.57019968
110MAP3K120.56747220
111MKNK10.56096120
112CDK140.53426686
113PRKD10.52985872
114CAMK2B0.52913237
115TEC0.52867618
116PNCK0.52789463
117FGR0.51518999
118STK110.51465876
119CDC70.50453032
120RPS6KA30.50226832
121WNK30.49900098
122CDK70.49720976
123CDK50.49706244
124BRSK10.48836090
125MATK0.48430891
126MAPKAPK50.48262919
127SRC0.47046958
128CAMK40.47028106
129TRPM70.46853106
130PRKCZ0.46683777
131MAP4K10.46562460
132HCK0.46149976
133CCNB10.45605302
134CAMK2A0.44939066
135MAPK120.44372235
136CDK190.43700913
137MAP3K130.43040832
138WEE10.42962495
139PAK30.42810324
140HIPK20.41603241
141CSNK1D0.41563347
142RPS6KA20.41161455
143MARK30.40269777
144BCR0.39238890
145TNK20.38500524
146CDK30.38377248
147TAF10.37046686

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.98391147
2Amphetamine addiction_Homo sapiens_hsa050311.98467866
3Basal cell carcinoma_Homo sapiens_hsa052171.97848935
4Axon guidance_Homo sapiens_hsa043601.94126617
5Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.88926653
6Synaptic vesicle cycle_Homo sapiens_hsa047211.77464829
7Hedgehog signaling pathway_Homo sapiens_hsa043401.75948467
8ECM-receptor interaction_Homo sapiens_hsa045121.64982137
9Dorso-ventral axis formation_Homo sapiens_hsa043201.63978112
10Cocaine addiction_Homo sapiens_hsa050301.62194154
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.57850548
12Insulin secretion_Homo sapiens_hsa049111.57352177
13Focal adhesion_Homo sapiens_hsa045101.53210959
14Phosphatidylinositol signaling system_Homo sapiens_hsa040701.46712205
15Colorectal cancer_Homo sapiens_hsa052101.46431837
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42305162
17Viral myocarditis_Homo sapiens_hsa054161.35472083
18Platelet activation_Homo sapiens_hsa046111.34916985
19Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.33941044
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33859000
21Endometrial cancer_Homo sapiens_hsa052131.30228620
22Glioma_Homo sapiens_hsa052141.28425465
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27543664
24Neurotrophin signaling pathway_Homo sapiens_hsa047221.27476736
25Renin secretion_Homo sapiens_hsa049241.27237771
26Notch signaling pathway_Homo sapiens_hsa043301.26714691
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.25596072
28Renal cell carcinoma_Homo sapiens_hsa052111.24392587
29Hippo signaling pathway_Homo sapiens_hsa043901.23910364
30Calcium signaling pathway_Homo sapiens_hsa040201.23850667
31Wnt signaling pathway_Homo sapiens_hsa043101.22843992
32Rap1 signaling pathway_Homo sapiens_hsa040151.22744977
33Phospholipase D signaling pathway_Homo sapiens_hsa040721.22597652
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22258784
35Inositol phosphate metabolism_Homo sapiens_hsa005621.21683890
36Type II diabetes mellitus_Homo sapiens_hsa049301.21438429
37Chronic myeloid leukemia_Homo sapiens_hsa052201.20690046
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.20370256
39Morphine addiction_Homo sapiens_hsa050321.20267336
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18154363
41Olfactory transduction_Homo sapiens_hsa047401.17548063
42Circadian entrainment_Homo sapiens_hsa047131.17291321
43Gap junction_Homo sapiens_hsa045401.17177704
44Pathways in cancer_Homo sapiens_hsa052001.16972973
45Taste transduction_Homo sapiens_hsa047421.14130003
46Proteoglycans in cancer_Homo sapiens_hsa052051.13710275
47MicroRNAs in cancer_Homo sapiens_hsa052061.13661694
48Melanogenesis_Homo sapiens_hsa049161.11847535
49B cell receptor signaling pathway_Homo sapiens_hsa046621.11712773
50Adherens junction_Homo sapiens_hsa045201.11640409
51VEGF signaling pathway_Homo sapiens_hsa043701.11100704
52Estrogen signaling pathway_Homo sapiens_hsa049151.10865035
53Glutamatergic synapse_Homo sapiens_hsa047241.09542367
54Non-small cell lung cancer_Homo sapiens_hsa052231.08382577
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.07916748
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07329940
57Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07198357
58Pancreatic cancer_Homo sapiens_hsa052121.05376196
59Cholinergic synapse_Homo sapiens_hsa047251.04938959
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.03697488
61Serotonergic synapse_Homo sapiens_hsa047261.02434495
62cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02182980
63Prolactin signaling pathway_Homo sapiens_hsa049171.01358570
64Sphingolipid signaling pathway_Homo sapiens_hsa040711.00086348
65Fatty acid biosynthesis_Homo sapiens_hsa000610.99782805
66cAMP signaling pathway_Homo sapiens_hsa040240.98944101
67PI3K-Akt signaling pathway_Homo sapiens_hsa041510.98676891
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98489997
69TGF-beta signaling pathway_Homo sapiens_hsa043500.97497401
70Small cell lung cancer_Homo sapiens_hsa052220.97026992
71Dopaminergic synapse_Homo sapiens_hsa047280.96861630
72Oxytocin signaling pathway_Homo sapiens_hsa049210.95866676
73Choline metabolism in cancer_Homo sapiens_hsa052310.94887090
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93731066
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93540163
76Salivary secretion_Homo sapiens_hsa049700.92606385
77Gastric acid secretion_Homo sapiens_hsa049710.91101807
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90022093
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88463456
80Chemokine signaling pathway_Homo sapiens_hsa040620.88163577
81Long-term depression_Homo sapiens_hsa047300.87797356
82ErbB signaling pathway_Homo sapiens_hsa040120.87776828
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86239985
84Ras signaling pathway_Homo sapiens_hsa040140.86170916
85Pancreatic secretion_Homo sapiens_hsa049720.86109576
86MAPK signaling pathway_Homo sapiens_hsa040100.85717291
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84644907
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84574338
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84250570
90GnRH signaling pathway_Homo sapiens_hsa049120.83666734
91Circadian rhythm_Homo sapiens_hsa047100.82477641
92Endocytosis_Homo sapiens_hsa041440.82438861
93Prostate cancer_Homo sapiens_hsa052150.81757107
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81717010
95Dilated cardiomyopathy_Homo sapiens_hsa054140.79931231
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77833908
97Melanoma_Homo sapiens_hsa052180.77658739
98Long-term potentiation_Homo sapiens_hsa047200.76159583
99Protein digestion and absorption_Homo sapiens_hsa049740.75822655
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75630998
101T cell receptor signaling pathway_Homo sapiens_hsa046600.74608922
102Acute myeloid leukemia_Homo sapiens_hsa052210.74377577
103GABAergic synapse_Homo sapiens_hsa047270.73508175
104Tight junction_Homo sapiens_hsa045300.72901426
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72788404
106FoxO signaling pathway_Homo sapiens_hsa040680.70484015
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69963312
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69044071
109Thyroid hormone synthesis_Homo sapiens_hsa049180.67902062
110AMPK signaling pathway_Homo sapiens_hsa041520.67646800
111Thyroid cancer_Homo sapiens_hsa052160.67605755
112Alcoholism_Homo sapiens_hsa050340.67425386
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.67087211
114Ovarian steroidogenesis_Homo sapiens_hsa049130.66312723
115Oocyte meiosis_Homo sapiens_hsa041140.65387328
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64742332
117HTLV-I infection_Homo sapiens_hsa051660.64621724
118mRNA surveillance pathway_Homo sapiens_hsa030150.64196149
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64048652
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63698564
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.63528920
122mTOR signaling pathway_Homo sapiens_hsa041500.63449491
123Hepatitis B_Homo sapiens_hsa051610.63052550
124Insulin signaling pathway_Homo sapiens_hsa049100.61285660
125Bile secretion_Homo sapiens_hsa049760.54808352
126Glucagon signaling pathway_Homo sapiens_hsa049220.53801969
127Lysine degradation_Homo sapiens_hsa003100.47539244
128Prion diseases_Homo sapiens_hsa050200.47530642

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