RNF146

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.10804872
2synaptic vesicle exocytosis (GO:0016079)4.79494795
3regulation of synaptic vesicle exocytosis (GO:2000300)4.51887007
4synaptic vesicle maturation (GO:0016188)4.51487955
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.38599268
6glutamate secretion (GO:0014047)4.29957899
7regulation of synaptic vesicle transport (GO:1902803)4.12899150
8presynaptic membrane assembly (GO:0097105)4.04537000
9regulation of glutamate receptor signaling pathway (GO:1900449)4.01087913
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.87524668
11locomotory exploration behavior (GO:0035641)3.83267638
12regulation of short-term neuronal synaptic plasticity (GO:0048172)3.82102184
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.81249328
14presynaptic membrane organization (GO:0097090)3.78603227
15neurotransmitter-gated ion channel clustering (GO:0072578)3.76512580
16regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.71747250
17neurotransmitter secretion (GO:0007269)3.70071848
18membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67786903
19establishment of nucleus localization (GO:0040023)3.66832289
20protein localization to synapse (GO:0035418)3.63816250
21vocalization behavior (GO:0071625)3.61916594
22regulation of synapse structural plasticity (GO:0051823)3.53211901
23regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.38757060
24postsynaptic membrane organization (GO:0001941)3.37102491
25inositol phosphate catabolic process (GO:0071545)3.36693036
26nucleobase catabolic process (GO:0046113)3.29979845
27sarcoplasmic reticulum calcium ion transport (GO:0070296)3.29853574
28neuron recognition (GO:0008038)3.29273583
29long-term synaptic potentiation (GO:0060291)3.28713326
30regulation of acyl-CoA biosynthetic process (GO:0050812)3.24244994
31axonal fasciculation (GO:0007413)3.20677231
32proline transport (GO:0015824)3.16370251
33negative regulation of dendrite development (GO:2000171)3.15566817
34regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.14334715
35cerebellar Purkinje cell differentiation (GO:0021702)3.12917722
36gamma-aminobutyric acid transport (GO:0015812)3.11645146
37cell migration in hindbrain (GO:0021535)3.10928852
38regulation of cell communication by electrical coupling (GO:0010649)3.10162885
39synapse assembly (GO:0007416)3.10064258
40regulation of coenzyme metabolic process (GO:0051196)3.07782850
41regulation of cofactor metabolic process (GO:0051193)3.07782850
42nerve growth factor signaling pathway (GO:0038180)3.07413204
43establishment of mitochondrion localization (GO:0051654)3.03491526
44regulation of NFAT protein import into nucleus (GO:0051532)3.01181357
45clathrin coat assembly (GO:0048268)3.00671280
46activation of protein kinase A activity (GO:0034199)2.97189671
47dendritic spine morphogenesis (GO:0060997)2.94962512
48neuronal action potential propagation (GO:0019227)2.94951366
49exploration behavior (GO:0035640)2.94579675
50auditory behavior (GO:0031223)2.94406626
51oxaloacetate metabolic process (GO:0006107)2.91731094
52positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.89954031
53dendrite morphogenesis (GO:0048813)2.89828412
54layer formation in cerebral cortex (GO:0021819)2.84444731
55negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.83312570
56positive regulation of synapse maturation (GO:0090129)2.83078393
57negative regulation of dendrite morphogenesis (GO:0050774)2.82426137
58innervation (GO:0060384)2.82414368
59positive regulation of synapse assembly (GO:0051965)2.78663363
60urinary tract smooth muscle contraction (GO:0014848)2.78054521
61negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78010705
62neuron cell-cell adhesion (GO:0007158)2.76987996
63COPI coating of Golgi vesicle (GO:0048205)2.76955879
64Golgi transport vesicle coating (GO:0048200)2.76955879
65vesicle transport along microtubule (GO:0047496)2.76934509
66synaptic transmission, glutamatergic (GO:0035249)2.76827230
67epithelial cell differentiation involved in kidney development (GO:0035850)2.76474146
68regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.75819740
69regulation of synaptic transmission, glutamatergic (GO:0051966)2.75118921
70calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.74200184
71signal complex assembly (GO:0007172)2.73119562
72membrane depolarization during action potential (GO:0086010)2.72601662
73succinate metabolic process (GO:0006105)2.70336911
74tricarboxylic acid cycle (GO:0006099)2.69183019
75synapse organization (GO:0050808)2.68162057
76long term synaptic depression (GO:0060292)2.68154045
77regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.66755161
78regulation of dendritic spine morphogenesis (GO:0061001)2.65271856
79ionotropic glutamate receptor signaling pathway (GO:0035235)2.64070731
80cell differentiation in hindbrain (GO:0021533)2.63568644
81lactate metabolic process (GO:0006089)2.62670799
82response to auditory stimulus (GO:0010996)2.62405554
83long-term memory (GO:0007616)2.62393940
84monoubiquitinated protein deubiquitination (GO:0035520)2.61659813
85regulation of neurotransmitter secretion (GO:0046928)2.61619449
86positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.61258162
87mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.61258162
88regulation of sodium ion transmembrane transporter activity (GO:2000649)2.60825897
89cerebellar granule cell differentiation (GO:0021707)2.60231024
90regulation of synapse assembly (GO:0051963)2.58537370
91positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.58271078
92regulation of neurotransmitter levels (GO:0001505)2.57959486
93positive regulation of membrane potential (GO:0045838)2.57923138
94actin-myosin filament sliding (GO:0033275)2.57919016
95muscle filament sliding (GO:0030049)2.57919016
96regulation of excitatory postsynaptic membrane potential (GO:0060079)2.57382769
97neuron-neuron synaptic transmission (GO:0007270)2.56579623
98nucleus localization (GO:0051647)2.56341755
99central nervous system projection neuron axonogenesis (GO:0021952)2.54825073
100positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.54656033
101regulation of neurotransmitter transport (GO:0051588)2.53356185
102neuromuscular synaptic transmission (GO:0007274)2.52801788
103pyrimidine nucleobase catabolic process (GO:0006208)2.52597522
104cerebellar Purkinje cell layer development (GO:0021680)2.52517984
105regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.52441036
106neurotransmitter transport (GO:0006836)2.52302133
107cell communication by electrical coupling (GO:0010644)2.51708700
108inositol phosphate dephosphorylation (GO:0046855)2.51127259
109phosphorylated carbohydrate dephosphorylation (GO:0046838)2.51127259
110spinal cord association neuron differentiation (GO:0021527)2.50927511
111organelle transport along microtubule (GO:0072384)2.50818492
112cardiac muscle hypertrophy in response to stress (GO:0014898)2.50682929
113muscle hypertrophy in response to stress (GO:0003299)2.50682929
114cardiac muscle adaptation (GO:0014887)2.50682929
115cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.50524869
116regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.50122385
117regulation of neuronal synaptic plasticity (GO:0048168)2.48258498
118synaptic vesicle transport (GO:0048489)2.47476286
119establishment of synaptic vesicle localization (GO:0097480)2.47476286
120positive regulation of cardiac muscle hypertrophy (GO:0010613)2.47412974
121positive regulation of muscle hypertrophy (GO:0014742)2.47412974
122transferrin transport (GO:0033572)2.47387965
123G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.46734022
124gamma-aminobutyric acid signaling pathway (GO:0007214)2.45384885
125regulation of relaxation of muscle (GO:1901077)2.44223032
126regulation of membrane repolarization (GO:0060306)2.43953861
127positive regulation of mitochondrial membrane permeability (GO:0035794)2.43303004
128positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.42302583
129regulation of synaptic plasticity (GO:0048167)2.42081421
130regulation of sulfur metabolic process (GO:0042762)2.41838763
131cellular potassium ion homeostasis (GO:0030007)2.41726969
132regulation of glucocorticoid secretion (GO:2000849)2.40919779
133axon extension (GO:0048675)2.40795301
134regulation of long-term neuronal synaptic plasticity (GO:0048169)2.40783137
135regulation of ion transmembrane transporter activity (GO:0032412)2.39599384
136regulation of cAMP-dependent protein kinase activity (GO:2000479)2.39513925
137regulation of respiratory system process (GO:0044065)2.38919655
138neuronal ion channel clustering (GO:0045161)2.38551521
139glutamate receptor signaling pathway (GO:0007215)2.38354407
140hippocampus development (GO:0021766)2.36598400
141regulation of dendritic spine development (GO:0060998)2.36551880
142negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.35755987
143heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.35672835
144regulation of postsynaptic membrane potential (GO:0060078)2.34544048
145synaptic vesicle endocytosis (GO:0048488)2.34181044
146positive regulation of dendritic spine development (GO:0060999)2.34092823
147axon ensheathment in central nervous system (GO:0032291)2.33475889
148central nervous system myelination (GO:0022010)2.33475889
149negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.32711740
150positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.32685773
151cellular sodium ion homeostasis (GO:0006883)2.32525434
152negative regulation of neurotransmitter transport (GO:0051589)2.29729524
153negative regulation of cytosolic calcium ion concentration (GO:0051481)2.28417146
154cardiac muscle contraction (GO:0060048)2.28364695
155regulation of synapse organization (GO:0050807)2.28243461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.91032081
2GBX2_23144817_ChIP-Seq_PC3_Human3.00908435
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.90656082
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.71608795
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.58677103
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.26464621
7AR_21572438_ChIP-Seq_LNCaP_Human2.20642480
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.16649094
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15588446
10IGF1R_20145208_ChIP-Seq_DFB_Human2.14372114
11TAF15_26573619_Chip-Seq_HEK293_Human2.14308795
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13808648
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.07628158
14* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93159871
15JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91698468
16CDX2_19796622_ChIP-Seq_MESCs_Mouse1.90744294
17REST_18959480_ChIP-ChIP_MESCs_Mouse1.85407778
18* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82431154
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.80100173
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79988132
21REST_21632747_ChIP-Seq_MESCs_Mouse1.79528371
22NR3C1_23031785_ChIP-Seq_PC12_Mouse1.76405011
23MTF2_20144788_ChIP-Seq_MESCs_Mouse1.74079969
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73535980
25SMAD4_21799915_ChIP-Seq_A2780_Human1.70996720
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.70762838
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.70762838
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70111907
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68051732
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64652308
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62622368
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.62107115
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61690203
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60668100
35SOX2_21211035_ChIP-Seq_LN229_Gbm1.60664699
36AR_25329375_ChIP-Seq_VCAP_Human1.60018906
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56836586
38ZNF274_21170338_ChIP-Seq_K562_Hela1.54948520
39P300_19829295_ChIP-Seq_ESCs_Human1.54846405
40DROSHA_22980978_ChIP-Seq_HELA_Human1.54116756
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.53402633
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.51849601
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51596884
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.49628791
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48507288
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44276980
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43807998
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40975040
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39782544
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38768121
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38735118
52TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38553226
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34853364
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32600543
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32565377
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31319745
57EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31285818
58FUS_26573619_Chip-Seq_HEK293_Human1.29892240
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28621293
60P53_22127205_ChIP-Seq_FIBROBLAST_Human1.28279891
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28165446
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27687223
63* STAT3_23295773_ChIP-Seq_U87_Human1.26818026
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.25716721
65ESR1_20079471_ChIP-ChIP_T-47D_Human1.25676335
66* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25127929
67AR_19668381_ChIP-Seq_PC3_Human1.24590535
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23597472
69* TCF4_23295773_ChIP-Seq_U87_Human1.23421796
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23341664
71BCAT_22108803_ChIP-Seq_LS180_Human1.21340896
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21039721
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21039721
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21028195
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21028195
76YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20976686
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20361197
78MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19243268
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.18484851
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18390837
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.17950052
82* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17827653
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.17428055
84LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16941595
85GATA1_22025678_ChIP-Seq_K562_Human1.16889409
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.15503600
87RXR_22108803_ChIP-Seq_LS180_Human1.13350463
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.11592799
89EP300_21415370_ChIP-Seq_HL-1_Mouse1.11202154
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.09753311
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09121946
92SOX9_26525672_Chip-Seq_HEART_Mouse1.07955876
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07937320
94CBP_20019798_ChIP-Seq_JUKART_Human1.07858693
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07858693
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07803766
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06871696
98* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06798588
99KDM2B_26808549_Chip-Seq_REH_Human1.06587637
100ER_23166858_ChIP-Seq_MCF-7_Human1.06001007
101WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05784331
102TP53_18474530_ChIP-ChIP_U2OS_Human1.05317830
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.05112017
104TAL1_26923725_Chip-Seq_HPCs_Mouse1.03458102
105* FLI1_21867929_ChIP-Seq_TH2_Mouse1.03183383
106HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01932731
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01839318
108TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01731778
109PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01708235
110RUNX2_22187159_ChIP-Seq_PCA_Human1.01556498
111JUN_21703547_ChIP-Seq_K562_Human1.01106957
112BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00204068
113CBX2_27304074_Chip-Seq_ESCs_Mouse0.99913001
114KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99289524
115RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98918992
116RNF2_27304074_Chip-Seq_NSC_Mouse0.98834059
117NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98180046
118STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98024182
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97657838
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97468753
121DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97088909
122* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96125111
123THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95985876
124RUNX_20019798_ChIP-Seq_JUKART_Human0.95131115
125RING1B_27294783_Chip-Seq_ESCs_Mouse0.94402851
126RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92432034
127TP53_16413492_ChIP-PET_HCT116_Human0.91860636
128IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91251066

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.26037071
2MP0004270_analgesia3.39412626
3MP0003880_abnormal_central_pattern3.37785821
4MP0003635_abnormal_synaptic_transmissio3.28126314
5MP0009780_abnormal_chondrocyte_physiolo2.98640020
6MP0003787_abnormal_imprinting2.93863256
7MP0002822_catalepsy2.79539203
8MP0002063_abnormal_learning/memory/cond2.77426989
9MP0002734_abnormal_mechanical_nocicepti2.40145561
10MP0009745_abnormal_behavioral_response2.35788513
11MP0002736_abnormal_nociception_after2.31925887
12MP0003879_abnormal_hair_cell2.24685305
13MP0002837_dystrophic_cardiac_calcinosis2.23277095
14MP0001968_abnormal_touch/_nociception2.18082139
15MP0000751_myopathy2.17981791
16MP0002064_seizures2.17215329
17MP0009046_muscle_twitch2.15826576
18MP0000569_abnormal_digit_pigmentation2.15546073
19MP0003646_muscle_fatigue2.11538220
20MP0004130_abnormal_muscle_cell2.01246440
21MP0008569_lethality_at_weaning1.98454606
22MP0003690_abnormal_glial_cell1.98216240
23MP0002572_abnormal_emotion/affect_behav1.95301850
24MP0001502_abnormal_circadian_rhythm1.87974851
25MP0002272_abnormal_nervous_system1.84258557
26MP0002184_abnormal_innervation1.81730815
27MP0004142_abnormal_muscle_tone1.73411175
28MP0005646_abnormal_pituitary_gland1.72417698
29MP0002067_abnormal_sensory_capabilities1.70933199
30MP0002909_abnormal_adrenal_gland1.69993500
31MP0004811_abnormal_neuron_physiology1.69908389
32MP0003724_increased_susceptibility_to1.64202009
33MP0010234_abnormal_vibrissa_follicle1.59347701
34MP0002735_abnormal_chemical_nociception1.57173593
35MP0005423_abnormal_somatic_nervous1.54782648
36MP0005167_abnormal_blood-brain_barrier1.52958102
37MP0004233_abnormal_muscle_weight1.51367320
38MP0001529_abnormal_vocalization1.49062954
39MP0006276_abnormal_autonomic_nervous1.47446242
40MP0000778_abnormal_nervous_system1.46179421
41MP0001501_abnormal_sleep_pattern1.45155766
42MP0000013_abnormal_adipose_tissue1.43517735
43MP0004885_abnormal_endolymph1.43138711
44MP0001486_abnormal_startle_reflex1.42048255
45MP0004084_abnormal_cardiac_muscle1.40229388
46MP0005386_behavior/neurological_phenoty1.37168372
47MP0004924_abnormal_behavior1.37168372
48MP0004215_abnormal_myocardial_fiber1.35599935
49MP0005248_abnormal_Harderian_gland1.34705988
50MP0000955_abnormal_spinal_cord1.34074022
51MP0001299_abnormal_eye_distance/1.31914551
52MP0004085_abnormal_heartbeat1.24207596
53MP0000920_abnormal_myelination1.21929991
54MP0002332_abnormal_exercise_endurance1.21369381
55MP0005645_abnormal_hypothalamus_physiol1.20644617
56MP0004036_abnormal_muscle_relaxation1.20555073
57MP0004145_abnormal_muscle_electrophysio1.20415339
58MP0002733_abnormal_thermal_nociception1.20109941
59MP0000747_muscle_weakness1.19819190
60MP0001986_abnormal_taste_sensitivity1.19088319
61MP0003632_abnormal_nervous_system1.18256640
62MP0004484_altered_response_of1.17803111
63MP0005620_abnormal_muscle_contractility1.17426717
64MP0002557_abnormal_social/conspecific_i1.17274993
65MP0003329_amyloid_beta_deposits1.16974590
66MP0002882_abnormal_neuron_morphology1.15784753
67MP0003137_abnormal_impulse_conducting1.15704859
68MP0001984_abnormal_olfaction1.15383092
69MP0002638_abnormal_pupillary_reflex1.15215568
70MP0001970_abnormal_pain_threshold1.14884600
71MP0000749_muscle_degeneration1.14739633
72MP0003634_abnormal_glial_cell1.13284653
73MP0001849_ear_inflammation1.08635813
74MP0003633_abnormal_nervous_system1.08230131
75MP0003303_peritoneal_inflammation1.08016920
76MP0003183_abnormal_peptide_metabolism1.06974144
77MP0006054_spinal_hemorrhage1.06126950
78MP0005187_abnormal_penis_morphology1.05159975
79MP0002066_abnormal_motor_capabilities/c1.05065650
80MP0000003_abnormal_adipose_tissue1.03682206
81MP0004858_abnormal_nervous_system1.03399162
82MP0001177_atelectasis1.02525982
83MP0002152_abnormal_brain_morphology1.02341396
84MP0003121_genomic_imprinting0.99798082
85MP0001905_abnormal_dopamine_level0.99291996
86MP0001958_emphysema0.98636183
87MP0001440_abnormal_grooming_behavior0.97649170
88MP0002876_abnormal_thyroid_physiology0.96278450
89MP0004510_myositis0.96040575
90MP0003122_maternal_imprinting0.95924181
91MP0008877_abnormal_DNA_methylation0.95850646
92MP0003221_abnormal_cardiomyocyte_apopto0.92278550
93MP0002972_abnormal_cardiac_muscle0.91599213
94MP0003631_nervous_system_phenotype0.90767497
95MP0006138_congestive_heart_failure0.90484703
96MP0010368_abnormal_lymphatic_system0.88867740
97MP0000750_abnormal_muscle_regeneration0.88080352
98MP0002106_abnormal_muscle_physiology0.87038541
99MP0005171_absent_coat_pigmentation0.85710896
100MP0004742_abnormal_vestibular_system0.85105004
101MP0003172_abnormal_lysosome_physiology0.84735937
102MP0004087_abnormal_muscle_fiber0.83856975
103MP0002752_abnormal_somatic_nervous0.83704794
104MP0000759_abnormal_skeletal_muscle0.82760168
105MP0005535_abnormal_body_temperature0.82711508
106MP0008775_abnormal_heart_ventricle0.82022375
107MP0002089_abnormal_postnatal_growth/wei0.79912134
108MP0002127_abnormal_cardiovascular_syste0.78955972
109MP0001188_hyperpigmentation0.78875164
110MP0003656_abnormal_erythrocyte_physiolo0.76295487
111MP0002069_abnormal_eating/drinking_beha0.76222027
112MP0005369_muscle_phenotype0.74449474
113MP0002108_abnormal_muscle_morphology0.73771901
114MP0002971_abnormal_brown_adipose0.73760635
115MP0005253_abnormal_eye_physiology0.72585090
116MP0000631_abnormal_neuroendocrine_gland0.72253840
117MP0004147_increased_porphyrin_level0.72185590
118MP0000026_abnormal_inner_ear0.72070972
119MP0002133_abnormal_respiratory_system0.72052839
120MP0002229_neurodegeneration0.67422187
121MP0000604_amyloidosis0.66284711
122MP0001943_abnormal_respiration0.65396506
123MP0004134_abnormal_chest_morphology0.65114878
124MP0001963_abnormal_hearing_physiology0.64678189
125MP0002234_abnormal_pharynx_morphology0.64079570
126MP0010769_abnormal_survival0.63481102
127MP0008961_abnormal_basal_metabolism0.63315246
128MP0002078_abnormal_glucose_homeostasis0.63278280
129MP0002282_abnormal_trachea_morphology0.60999779
130MP0010770_preweaning_lethality0.60666596

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.01895229
2Visual hallucinations (HP:0002367)4.56029200
3Febrile seizures (HP:0002373)4.27808061
4Epileptic encephalopathy (HP:0200134)4.15691807
5Absence seizures (HP:0002121)4.08695616
6Atonic seizures (HP:0010819)3.93071478
7Focal seizures (HP:0007359)3.90778174
8Papillary thyroid carcinoma (HP:0002895)3.66555152
9Pheochromocytoma (HP:0002666)3.59068608
10Neuroendocrine neoplasm (HP:0100634)3.39349164
11Dialeptic seizures (HP:0011146)3.37754881
12Impaired vibration sensation in the lower limbs (HP:0002166)3.33601622
13Muscle fiber splitting (HP:0003555)3.16973451
14Type 1 muscle fiber predominance (HP:0003803)3.13968884
15Rimmed vacuoles (HP:0003805)2.97813865
16Polyphagia (HP:0002591)2.91863647
17Neurofibrillary tangles (HP:0002185)2.88010241
18Lower limb muscle weakness (HP:0007340)2.86838561
19Myokymia (HP:0002411)2.86491632
20Progressive inability to walk (HP:0002505)2.85836793
21Fetal akinesia sequence (HP:0001989)2.83997357
22Ankle clonus (HP:0011448)2.82788772
23Urinary urgency (HP:0000012)2.75760020
24Spinal canal stenosis (HP:0003416)2.72203143
25Broad-based gait (HP:0002136)2.60466223
26Amyotrophic lateral sclerosis (HP:0007354)2.60252753
27Hemiplegia (HP:0002301)2.55844988
28Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.55668943
29Degeneration of the lateral corticospinal tracts (HP:0002314)2.55668943
30Blue irides (HP:0000635)2.55348297
31Abnormality of the corticospinal tract (HP:0002492)2.51557933
32Cerebral inclusion bodies (HP:0100314)2.50725758
33Generalized tonic-clonic seizures (HP:0002069)2.48345135
34Inappropriate behavior (HP:0000719)2.46151245
35Hyperventilation (HP:0002883)2.45535447
36Truncal ataxia (HP:0002078)2.43888234
37Exercise-induced myalgia (HP:0003738)2.43241229
38Abnormality of the lower motor neuron (HP:0002366)2.42475239
39Papilledema (HP:0001085)2.41704388
40Rapidly progressive (HP:0003678)2.41437637
41Shoulder girdle muscle weakness (HP:0003547)2.32109108
42Absent speech (HP:0001344)2.31842890
43Long toe (HP:0010511)2.31272849
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30749629
45Abnormality of alanine metabolism (HP:0010916)2.30749629
46Hyperalaninemia (HP:0003348)2.30749629
47Neoplasm of the peripheral nervous system (HP:0100007)2.30107821
48Epileptiform EEG discharges (HP:0011182)2.25202802
49Poor eye contact (HP:0000817)2.24929509
50Bundle branch block (HP:0011710)2.23067142
51Disinhibition (HP:0000734)2.22466620
52Distal arthrogryposis (HP:0005684)2.22340929
53Frequent falls (HP:0002359)2.22110051
54Subaortic stenosis (HP:0001682)2.21560601
55Abnormality of the left ventricular outflow tract (HP:0011103)2.21560601
56Oligomenorrhea (HP:0000876)2.20904551
57Drooling (HP:0002307)2.19605652
58Excessive salivation (HP:0003781)2.19605652
59Thyroid carcinoma (HP:0002890)2.19600222
60Scanning speech (HP:0002168)2.19452985
61Agitation (HP:0000713)2.17968287
62Limb dystonia (HP:0002451)2.17285682
63Hemiparesis (HP:0001269)2.13369411
64Abnormality of the musculature of the pelvis (HP:0001469)2.12718381
65Abnormality of the hip-girdle musculature (HP:0001445)2.12718381
66Abnormality of binocular vision (HP:0011514)2.12080902
67Diplopia (HP:0000651)2.12080902
68Termporal pattern (HP:0011008)2.11015720
69Insidious onset (HP:0003587)2.11015720
70Peripheral hypomyelination (HP:0007182)2.10195441
71Supranuclear gaze palsy (HP:0000605)2.09712683
72EEG with generalized epileptiform discharges (HP:0011198)2.09102376
73Myotonia (HP:0002486)2.08586597
74Abnormal social behavior (HP:0012433)2.05444766
75Impaired social interactions (HP:0000735)2.05444766
76Ventricular fibrillation (HP:0001663)2.04039944
77Postural instability (HP:0002172)2.01785302
78Depression (HP:0000716)1.99921565
79Central scotoma (HP:0000603)1.99868590
80Severe short stature (HP:0003510)1.99429475
81Torticollis (HP:0000473)1.98853404
82Abnormality of salivation (HP:0100755)1.98780184
83Hypoplasia of the brainstem (HP:0002365)1.98480826
84Aplasia/Hypoplasia of the brainstem (HP:0007362)1.98480826
85EMG: neuropathic changes (HP:0003445)1.98390909
86Progressive cerebellar ataxia (HP:0002073)1.97036326
87Urinary bladder sphincter dysfunction (HP:0002839)1.95837672
88Hyporeflexia of lower limbs (HP:0002600)1.95647213
89Facial diplegia (HP:0001349)1.95612543
90Hypsarrhythmia (HP:0002521)1.95400915
91Inability to walk (HP:0002540)1.95335903
92Intention tremor (HP:0002080)1.94433048
93Resting tremor (HP:0002322)1.94087921
94Action tremor (HP:0002345)1.92236210
95Limb-girdle muscle atrophy (HP:0003797)1.91945479
96Limb-girdle muscle weakness (HP:0003325)1.90671928
97Abnormality of the foot musculature (HP:0001436)1.90259765
98Exercise-induced muscle cramps (HP:0003710)1.90099721
99Enlarged kidneys (HP:0000105)1.89758417
100Spastic gait (HP:0002064)1.88798064
101Sudden death (HP:0001699)1.88577181
102Gowers sign (HP:0003391)1.88208875
103Ragged-red muscle fibers (HP:0003200)1.88154688
104Specific learning disability (HP:0001328)1.87503467
105Congenital primary aphakia (HP:0007707)1.87032613
106EMG: myopathic abnormalities (HP:0003458)1.86769685
107Sensorimotor neuropathy (HP:0007141)1.84955727
108Cortical dysplasia (HP:0002539)1.84657507
109Neuronal loss in central nervous system (HP:0002529)1.82258124
110Dysmetric saccades (HP:0000641)1.80055560
111Neoplasm of the adrenal gland (HP:0100631)1.79966935
112Abnormal EKG (HP:0003115)1.79897701
113Hepatoblastoma (HP:0002884)1.79526871
114Striae distensae (HP:0001065)1.79009258
115Neoplasm of the heart (HP:0100544)1.78792285
116Calf muscle hypertrophy (HP:0008981)1.78600419
117Abnormal hair whorl (HP:0010721)1.78020488
118Muscle hypertrophy of the lower extremities (HP:0008968)1.77571859
119Impaired vibratory sensation (HP:0002495)1.77304242
120Mutism (HP:0002300)1.76552494
121Protruding tongue (HP:0010808)1.76312862
122Ulnar deviation of the wrist (HP:0003049)1.75936827
123Poor speech (HP:0002465)1.75580918
124Steppage gait (HP:0003376)1.75516927
125Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75494667
126Asymmetric septal hypertrophy (HP:0001670)1.74645364
127Difficulty climbing stairs (HP:0003551)1.74625619
128Abnormality of the calf musculature (HP:0001430)1.74245220
129Nephrogenic diabetes insipidus (HP:0009806)1.72435713
130Hypoplasia of the corpus callosum (HP:0002079)1.72106221
131Muscle fiber inclusion bodies (HP:0100299)1.70819183
132Increased variability in muscle fiber diameter (HP:0003557)1.69788950
133Abnormality of skeletal muscle fiber size (HP:0012084)1.69354178
134Labial hypoplasia (HP:0000066)1.69335468
135Hypothermia (HP:0002045)1.68899297
136Clonus (HP:0002169)1.68285684
137Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.68007774
138Dysmetria (HP:0001310)1.66492128
139Apathy (HP:0000741)1.66443639
140Impaired smooth pursuit (HP:0007772)1.66286348
141Round ear (HP:0100830)1.65729705
142Foot dorsiflexor weakness (HP:0009027)1.65494042
143Anxiety (HP:0000739)1.65031115
144Focal dystonia (HP:0004373)1.64907237
145Hamartoma of the eye (HP:0010568)1.64794953
146Intellectual disability, profound (HP:0002187)1.63128488
147Pelvic girdle muscle weakness (HP:0003749)1.63036883
148Gait imbalance (HP:0002141)1.62204289
149Genetic anticipation (HP:0003743)1.62004660
150Abnormal eating behavior (HP:0100738)1.61761508
151Exotropia (HP:0000577)1.60366973
152Volvulus (HP:0002580)1.59725273
153Nemaline bodies (HP:0003798)1.57962489
154Incomplete penetrance (HP:0003829)1.57146400
155Amblyopia (HP:0000646)1.56635323
156Complete atrioventricular canal defect (HP:0001674)1.56243602
157Generalized hypopigmentation of hair (HP:0011358)1.55386815
158Difficulty running (HP:0009046)1.53964213

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K43.01287604
2MARK12.86639608
3MAP3K122.85869823
4OBSCN2.73519415
5MAP2K72.71238323
6FGFR22.70672066
7NTRK22.54146421
8NTRK32.46289291
9MINK12.35447179
10PDK32.33139074
11PDK42.33139074
12SIK21.98135618
13CDK191.97360007
14MUSK1.93804392
15PRPF4B1.93555518
16ERBB31.91987582
17MAP2K41.90813368
18CASK1.89349528
19KSR11.84322080
20FGFR31.78609638
21SGK21.76133301
22TRIB31.74947023
23MAPK131.61448776
24DAPK21.58202043
25PDGFRA1.55574495
26SIK31.53693258
27MAP3K91.49912750
28SGK31.48173931
29PLK21.40773913
30SGK2231.39025031
31SGK4941.39025031
32TYRO31.38083587
33RET1.36556845
34FGFR41.35148328
35DYRK31.30703462
36EPHA41.28766398
37MAP4K21.21023542
38CCNB11.20333736
39FGR1.17072241
40DYRK1A1.14968785
41PRKCH1.14632227
42CAMKK21.12747080
43IRAK21.07504531
44CAMKK11.03606403
45LATS21.02417055
46PTK2B1.01407002
47TTN0.98853640
48NEK90.98796652
49PAK60.96573808
50DAPK10.96442436
51EPHB10.94142389
52GRK70.93169088
53BLK0.91963458
54RPS6KA40.91521571
55ITK0.89152855
56PKN20.86718926
57PHKG10.86051745
58PHKG20.86051745
59MAP3K130.85094897
60KSR20.84834538
61PDGFRB0.84247659
62CDK50.83530096
63PDK20.83150057
64NTRK10.82709941
65DYRK20.80969397
66LMTK20.80631133
67BCR0.79629892
68EEF2K0.78899998
69RIPK40.78143030
70CSNK1A1L0.75340148
71LATS10.73484784
72EPHA30.73483466
73WNK30.71995917
74FGFR10.71952135
75MAP3K50.71875823
76MAP3K70.71062441
77TSSK60.69184779
78STK110.68819952
79CSNK1G30.68731063
80PDK10.67722888
81UHMK10.67602899
82MAP3K60.67440155
83TAOK10.67355278
84PINK10.66298541
85AKT30.65334610
86PRKCE0.65023092
87CSNK1G20.64933827
88JAK20.63678371
89STK240.63655362
90PAK30.63635575
91EPHB20.63550337
92PRKCZ0.62814928
93ROCK10.60982095
94CAMK40.59001491
95DYRK1B0.58920941
96CAMK2A0.58349089
97TXK0.58155880
98YES10.58063558
99MOS0.58036966
100TIE10.57888891
101DDR20.57793085
102CAMK2B0.56996851
103CAMK2G0.56651745
104DMPK0.54689836
105RAF10.54504287
106FYN0.54076298
107SGK10.54063242
108NEK10.53190586
109ACVR1B0.52083051
110MAP3K100.50834339
111RPS6KA20.50488615
112CSNK1G10.50329047
113MAPK120.49040227
114RIPK10.48234953
115BRAF0.46762324
116PKN10.44039545
117PRKD10.43963015
118MARK20.42537523
119PNCK0.41908182
120SRPK10.41677053
121PRKG10.41329502
122CDK140.41299341
123GRK50.41182054
124CAMK1G0.40772056
125PRKCG0.40559932
126PRKAA10.40450842
127CAMK2D0.38835173
128ADRBK20.37525303
129PRKD30.37515709
130ARAF0.37410406
131PDPK10.36937283
132CSK0.36687728
133CDK180.36521467
134FES0.35585920
135LIMK10.35154421
136CAMK10.34771944
137MAPK100.34497423
138ILK0.34276738
139MAPK70.33350010
140ERBB40.31509639
141JAK10.30946638

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.13097599
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.47986100
3Nicotine addiction_Homo sapiens_hsa050332.37665341
4Olfactory transduction_Homo sapiens_hsa047402.37530906
5Circadian rhythm_Homo sapiens_hsa047102.30026109
6Circadian entrainment_Homo sapiens_hsa047132.01879596
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.92776842
8GABAergic synapse_Homo sapiens_hsa047271.86776941
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.86726274
10Long-term potentiation_Homo sapiens_hsa047201.82380463
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.74958254
12Dopaminergic synapse_Homo sapiens_hsa047281.66122504
13Amphetamine addiction_Homo sapiens_hsa050311.63583693
14Morphine addiction_Homo sapiens_hsa050321.62677766
15Insulin secretion_Homo sapiens_hsa049111.55730793
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55549666
17Vibrio cholerae infection_Homo sapiens_hsa051101.52197499
18Glutamatergic synapse_Homo sapiens_hsa047241.49505496
19Collecting duct acid secretion_Homo sapiens_hsa049661.47522017
20Oxytocin signaling pathway_Homo sapiens_hsa049211.43454917
21Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.37130981
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36425266
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26993368
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26424232
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25916891
26Dilated cardiomyopathy_Homo sapiens_hsa054141.25549889
27Renin secretion_Homo sapiens_hsa049241.24744426
28Neurotrophin signaling pathway_Homo sapiens_hsa047221.17782626
29Salivary secretion_Homo sapiens_hsa049701.17526202
30ErbB signaling pathway_Homo sapiens_hsa040121.15956454
31Dorso-ventral axis formation_Homo sapiens_hsa043201.15217416
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13624741
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12590623
34Cholinergic synapse_Homo sapiens_hsa047251.11704933
35Glucagon signaling pathway_Homo sapiens_hsa049221.11498839
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11320575
37Colorectal cancer_Homo sapiens_hsa052101.10035454
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08842951
39Taste transduction_Homo sapiens_hsa047421.08115803
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06257044
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06168888
42Cardiac muscle contraction_Homo sapiens_hsa042601.04883475
43Axon guidance_Homo sapiens_hsa043601.04814829
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.03953586
45Gastric acid secretion_Homo sapiens_hsa049711.03080080
46Cocaine addiction_Homo sapiens_hsa050301.02154646
47Calcium signaling pathway_Homo sapiens_hsa040201.01512170
48MAPK signaling pathway_Homo sapiens_hsa040101.00128747
49Type II diabetes mellitus_Homo sapiens_hsa049300.99777661
50cAMP signaling pathway_Homo sapiens_hsa040240.98995638
51GnRH signaling pathway_Homo sapiens_hsa049120.98275725
52Glioma_Homo sapiens_hsa052140.94313670
53Long-term depression_Homo sapiens_hsa047300.94102738
54Endometrial cancer_Homo sapiens_hsa052130.94062868
55Regulation of autophagy_Homo sapiens_hsa041400.91721049
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91366112
57Serotonergic synapse_Homo sapiens_hsa047260.90094906
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88333680
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.85116623
60Phototransduction_Homo sapiens_hsa047440.85100970
61Pancreatic cancer_Homo sapiens_hsa052120.84767653
62T cell receptor signaling pathway_Homo sapiens_hsa046600.84676282
63Insulin signaling pathway_Homo sapiens_hsa049100.84061021
64mTOR signaling pathway_Homo sapiens_hsa041500.83536073
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83283987
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83122598
67VEGF signaling pathway_Homo sapiens_hsa043700.81617128
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81347214
69Osteoclast differentiation_Homo sapiens_hsa043800.81203793
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79131501
71Pyruvate metabolism_Homo sapiens_hsa006200.78161274
72Oocyte meiosis_Homo sapiens_hsa041140.78012461
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77946459
74Endocytosis_Homo sapiens_hsa041440.77399841
75Gap junction_Homo sapiens_hsa045400.77302158
76Prolactin signaling pathway_Homo sapiens_hsa049170.76495371
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76148436
78Estrogen signaling pathway_Homo sapiens_hsa049150.75874222
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75641308
80Non-small cell lung cancer_Homo sapiens_hsa052230.72916663
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72654800
82Shigellosis_Homo sapiens_hsa051310.71685751
83Ras signaling pathway_Homo sapiens_hsa040140.70066673
84AMPK signaling pathway_Homo sapiens_hsa041520.69915635
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68806921
86FoxO signaling pathway_Homo sapiens_hsa040680.67468474
87Insulin resistance_Homo sapiens_hsa049310.67369259
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66883495
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.64361952
90Tuberculosis_Homo sapiens_hsa051520.63982853
91Chemokine signaling pathway_Homo sapiens_hsa040620.59300891
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59197346
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58620808
94Phagosome_Homo sapiens_hsa041450.57322472
95B cell receptor signaling pathway_Homo sapiens_hsa046620.57285090
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56417002
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56175711
98Inositol phosphate metabolism_Homo sapiens_hsa005620.55389763
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54493097
100Staphylococcus aureus infection_Homo sapiens_hsa051500.53502737
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53451056
102Pertussis_Homo sapiens_hsa051330.52713809
103ABC transporters_Homo sapiens_hsa020100.52638990
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51405639
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51292950
106Rap1 signaling pathway_Homo sapiens_hsa040150.50725889
107Thyroid hormone synthesis_Homo sapiens_hsa049180.49966259
108Amoebiasis_Homo sapiens_hsa051460.49223780
109Renal cell carcinoma_Homo sapiens_hsa052110.48390975
110Hedgehog signaling pathway_Homo sapiens_hsa043400.47866054
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47557856
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47212639
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46755360
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.46720048
115Melanogenesis_Homo sapiens_hsa049160.46201862
116Chronic myeloid leukemia_Homo sapiens_hsa052200.44805379
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.44429829
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.44113735
119Choline metabolism in cancer_Homo sapiens_hsa052310.42493548
120Focal adhesion_Homo sapiens_hsa045100.42134649
121Notch signaling pathway_Homo sapiens_hsa043300.41875098
122Salmonella infection_Homo sapiens_hsa051320.41746254
123Lysosome_Homo sapiens_hsa041420.41211782
124Wnt signaling pathway_Homo sapiens_hsa043100.40163588
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38662638

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