RNF148

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.88988845
2motile cilium assembly (GO:0044458)9.57485133
3axonemal dynein complex assembly (GO:0070286)9.48455174
4epithelial cilium movement (GO:0003351)9.46522214
5reproduction (GO:0000003)9.32933729
6response to pheromone (GO:0019236)8.93819476
7regulation of cilium movement (GO:0003352)8.65843694
8cilium or flagellum-dependent cell motility (GO:0001539)8.30077331
9cilium movement (GO:0003341)7.59417351
10negative regulation of inclusion body assembly (GO:0090084)7.52971830
11single fertilization (GO:0007338)7.31222838
12rRNA methylation (GO:0031167)7.20666571
13sperm capacitation (GO:0048240)7.10534601
14protein targeting to Golgi (GO:0000042)7.10076965
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.04449431
16organic cation transport (GO:0015695)6.94798181
17spermatogenesis (GO:0007283)6.91364740
18male gamete generation (GO:0048232)6.88794967
19synaptonemal complex organization (GO:0070193)6.85573269
20establishment of protein localization to Golgi (GO:0072600)6.81311948
21microtubule depolymerization (GO:0007019)6.76984375
22synaptonemal complex assembly (GO:0007130)6.71485283
23piRNA metabolic process (GO:0034587)6.62682086
24retrograde transport, vesicle recycling within Golgi (GO:0000301)6.62519188
25male meiosis (GO:0007140)6.59050527
26gamete generation (GO:0007276)6.33051030
27regulation of inclusion body assembly (GO:0090083)6.27410149
28fertilization (GO:0009566)6.21010394
29rRNA modification (GO:0000154)6.03856408
30phosphatidylethanolamine biosynthetic process (GO:0006646)6.03008035
31calcium ion-dependent exocytosis (GO:0017156)5.84066043
32chromosome condensation (GO:0030261)5.75993786
33centriole replication (GO:0007099)5.75173434
34phosphatidylethanolamine metabolic process (GO:0046337)5.56411316
35germ cell development (GO:0007281)5.46017522
36DNA packaging (GO:0006323)5.44412638
37cellular process involved in reproduction in multicellular organism (GO:0022412)5.39329868
38cellular ketone body metabolic process (GO:0046950)5.36382674
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.22836313
40spermatid nucleus differentiation (GO:0007289)5.21989418
41glycerol ether metabolic process (GO:0006662)5.21898530
42protein localization to Golgi apparatus (GO:0034067)5.12775091
43cell recognition (GO:0008037)5.10680819
44regulation of microtubule-based movement (GO:0060632)5.10615224
45centriole assembly (GO:0098534)5.06275685
46regulation of Rab GTPase activity (GO:0032313)4.99548775
47positive regulation of Rab GTPase activity (GO:0032851)4.99548775
48multicellular organismal reproductive process (GO:0048609)4.98165235
49ventricular system development (GO:0021591)4.93608013
50regulation of centriole replication (GO:0046599)4.84607696
51ether metabolic process (GO:0018904)4.82400766
52ketone body metabolic process (GO:1902224)4.72506909
53microtubule severing (GO:0051013)4.62857635
54male meiosis I (GO:0007141)4.57897250
55seminiferous tubule development (GO:0072520)4.56673799
56chromosome organization involved in meiosis (GO:0070192)4.52129354
57sexual reproduction (GO:0019953)4.38542054
58chaperone-mediated protein complex assembly (GO:0051131)4.30485760
59DNA methylation involved in gamete generation (GO:0043046)4.26953669
60left/right pattern formation (GO:0060972)4.26657967
61glomerular visceral epithelial cell development (GO:0072015)4.25775055
62regulation of transcription involved in cell fate commitment (GO:0060850)4.19911620
63single strand break repair (GO:0000012)4.14215683
64glomerular epithelial cell development (GO:0072310)4.04792449
65multicellular organismal development (GO:0007275)4.02433419
66meiotic nuclear division (GO:0007126)3.99578466
67negative regulation of Rho protein signal transduction (GO:0035024)3.93735117
68coenzyme catabolic process (GO:0009109)3.85894224
69multicellular organismal movement (GO:0050879)3.82878441
70musculoskeletal movement (GO:0050881)3.82878441
71sequestering of actin monomers (GO:0042989)3.69913340
72cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.67222908
73meiosis I (GO:0007127)3.64276020
74microtubule polymerization or depolymerization (GO:0031109)3.47960152
75regulation of spindle checkpoint (GO:0090231)3.45384680
76protein polyglutamylation (GO:0018095)3.45162828
77microtubule nucleation (GO:0007020)3.42656368
78genitalia morphogenesis (GO:0035112)3.34076257
79protein refolding (GO:0042026)3.30420384
80protein K11-linked deubiquitination (GO:0035871)3.28922876
81histone H3-K9 demethylation (GO:0033169)3.24364186
82protein depolymerization (GO:0051261)3.23454466
83carnitine transport (GO:0015879)3.23290779
84amino-acid betaine transport (GO:0015838)3.23290779
85protein-DNA complex disassembly (GO:0032986)3.21071476
86nucleosome disassembly (GO:0006337)3.21071476
87meiotic cell cycle (GO:0051321)3.20215650
88cerebral cortex neuron differentiation (GO:0021895)3.17058915
89nucleus organization (GO:0006997)3.16107314
90regulation of interleukin-13 production (GO:0032656)3.16007762
91positive regulation of macrophage activation (GO:0043032)3.15368441
92negative regulation of gene expression, epigenetic (GO:0045814)3.15361744
93glycolytic process (GO:0006096)3.14940722
94response to acidic pH (GO:0010447)3.14678316
95peptidyl-threonine dephosphorylation (GO:0035970)3.12120509
96cellular response to pH (GO:0071467)3.10729595
97interferon-gamma secretion (GO:0072643)3.09902998
98mitotic sister chromatid cohesion (GO:0007064)3.07409345
99RNA localization (GO:0006403)3.05728410
100protein localization to cilium (GO:0061512)3.05206325
101polyol catabolic process (GO:0046174)3.04446314
102mesenchymal cell differentiation involved in kidney development (GO:0072161)3.03956349
103mesenchymal cell differentiation involved in renal system development (GO:2001012)3.03956349
104carnitine transmembrane transport (GO:1902603)3.03860115
105DNA conformation change (GO:0071103)3.02029729
106RNA destabilization (GO:0050779)3.00411582
107homeostasis of number of cells within a tissue (GO:0048873)2.95497747
108nucleoside diphosphate phosphorylation (GO:0006165)2.94421788
109polyamine biosynthetic process (GO:0006596)2.94122867
110alditol metabolic process (GO:0019400)2.93243384
111cell differentiation involved in metanephros development (GO:0072202)2.92503134
112regulation of T-helper 2 cell differentiation (GO:0045628)2.92316124
113monoubiquitinated protein deubiquitination (GO:0035520)2.86419072
114receptor recycling (GO:0001881)2.82230810
115cranial nerve morphogenesis (GO:0021602)2.81142604
116regulation of cilium assembly (GO:1902017)2.78494390
117nuclear pore complex assembly (GO:0051292)2.75836905
118chromatin silencing (GO:0006342)2.75497964
119regulation of somitogenesis (GO:0014807)2.69942167
120NAD biosynthetic process (GO:0009435)2.69646095
121mitotic G1 DNA damage checkpoint (GO:0031571)2.69499269
122negative regulation of histone methylation (GO:0031061)2.69091318
123cilium organization (GO:0044782)2.67685271
124GTP biosynthetic process (GO:0006183)2.66008217
125cilium morphogenesis (GO:0060271)2.63144871
126mitochondrion degradation (GO:0000422)2.62857141
127meiotic cell cycle process (GO:1903046)2.62648035
128synapsis (GO:0007129)2.62015482
129microtubule-based movement (GO:0007018)2.60201418
130cellular component assembly involved in morphogenesis (GO:0010927)2.58761132
131cilium assembly (GO:0042384)2.57994858
132axoneme assembly (GO:0035082)2.52493692
133peptidyl-glutamic acid modification (GO:0018200)2.51568053
134intraciliary transport (GO:0042073)2.44712267
135membrane protein intracellular domain proteolysis (GO:0031293)2.43814327
136glycerol metabolic process (GO:0006071)2.43616977
137lactate metabolic process (GO:0006089)2.41948071
138positive regulation of glycolytic process (GO:0045821)2.41864504
139sperm motility (GO:0030317)14.1853011
140cell wall macromolecule metabolic process (GO:0044036)13.7686776
141cell wall macromolecule catabolic process (GO:0016998)13.7686776
142fusion of sperm to egg plasma membrane (GO:0007342)13.2939784
143acrosome reaction (GO:0007340)12.6342364
144sperm-egg recognition (GO:0035036)11.6913520
145acrosome assembly (GO:0001675)11.6315484
146multicellular organism reproduction (GO:0032504)10.7418849
147binding of sperm to zona pellucida (GO:0007339)10.5680769
148cell-cell recognition (GO:0009988)10.4588688
149plasma membrane fusion (GO:0045026)10.1249228

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.16769983
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.50787153
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.39598176
4EZH2_22144423_ChIP-Seq_EOC_Human4.16745338
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.71923852
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.69882371
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.04267483
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.01187728
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.87462684
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.83535267
11VDR_22108803_ChIP-Seq_LS180_Human2.59764285
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.29737389
13CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.25583023
14ZNF274_21170338_ChIP-Seq_K562_Hela2.10624553
15FUS_26573619_Chip-Seq_HEK293_Human2.04650347
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.04182368
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03941445
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.97541631
19VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.94368831
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92873960
21ERA_21632823_ChIP-Seq_H3396_Human1.92836247
22DROSHA_22980978_ChIP-Seq_HELA_Human1.87683420
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.85439234
24ELK4_26923725_Chip-Seq_MESODERM_Mouse1.80789342
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.80671943
26KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.78818649
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.76948200
28* RAC3_21632823_ChIP-Seq_H3396_Human1.76388923
29FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76373815
30MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.75750591
31STAT1_17558387_ChIP-Seq_HELA_Human1.71795418
32TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.70566594
33ARNT_22903824_ChIP-Seq_MCF-7_Human1.69175540
34RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.65090864
35CTCF_27219007_Chip-Seq_Bcells_Human1.64196575
36ER_23166858_ChIP-Seq_MCF-7_Human1.62776645
37* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.61841845
38GATA3_21867929_ChIP-Seq_CD8_Mouse1.60843992
39EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.60027439
40MYC_19829295_ChIP-Seq_ESCs_Human1.58850134
41SMAD4_21741376_ChIP-Seq_EPCs_Human1.56615416
42TDRD3_21172665_ChIP-Seq_MCF-7_Human1.55192241
43GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.54122696
44WDR5_24793694_ChIP-Seq_LNCAP_Human1.53065005
45TP53_18474530_ChIP-ChIP_U2OS_Human1.50756866
46BCL6_27268052_Chip-Seq_Bcells_Human1.49052570
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49043363
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.48553247
49FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.47738631
50SMC4_20622854_ChIP-Seq_HELA_Human1.46284317
51* TAF2_19829295_ChIP-Seq_ESCs_Human1.45982480
52E2F1_20622854_ChIP-Seq_HELA_Human1.45713690
53PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.45346527
54KDM2B_26808549_Chip-Seq_REH_Human1.45135081
55TP63_22573176_ChIP-Seq_HFKS_Human1.44359175
56AR_25329375_ChIP-Seq_VCAP_Human1.43397406
57TAL1_26923725_Chip-Seq_HPCs_Mouse1.43204688
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42527856
59PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.42128482
60CBX2_22325352_ChIP-Seq_293T-Rex_Human1.41436121
61HNFA_21074721_ChIP-Seq_CACO-2_Human1.40257184
62LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.38494121
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38392405
64CBP_20019798_ChIP-Seq_JUKART_Human1.38392405
65OCT4_20526341_ChIP-Seq_ESCs_Human1.38282785
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.37335379
67REST_21632747_ChIP-Seq_MESCs_Mouse1.36861869
68P53_21459846_ChIP-Seq_SAOS-2_Human1.36588548
69PHF8_20622854_ChIP-Seq_HELA_Human1.36046748
70P68_20966046_ChIP-Seq_HELA_Human1.35851305
71RBPJ_21746931_ChIP-Seq_IB4_Human1.35279690
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35032950
73KAP1_22055183_ChIP-Seq_ESCs_Mouse1.34482409
74CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.33338837
75SMAD3_21741376_ChIP-Seq_ESCs_Human1.32080530
76SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31651910
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.31377567
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31225516
79P300_19829295_ChIP-Seq_ESCs_Human1.30658216
80ETV1_20927104_ChIP-Seq_GIST48_Human1.29624439
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.29155925
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26878416
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26517740
84GF1_26923725_Chip-Seq_HPCs_Mouse1.26361619
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25941164
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25870210
87GATA3_21867929_ChIP-Seq_TH1_Mouse1.24334137
88SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24246561
89CEBPB_22108803_ChIP-Seq_LS180_Human1.22925219
90LXR_22292898_ChIP-Seq_THP-1_Human1.22924312
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.22314393
92RAD21_21589869_ChIP-Seq_MESCs_Mouse1.22235448
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.21873653
94TBL1_22424771_ChIP-Seq_293T_Human1.21006795
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20665623
96P300_27268052_Chip-Seq_Bcells_Human1.20584425
97CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18881365
98CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18292244
99RUNX_20019798_ChIP-Seq_JUKART_Human1.17813367
100SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17694434
101SMAD4_21741376_ChIP-Seq_HESCs_Human1.17551766
102P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.16578777
103CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16149369
104* GATA3_21878914_ChIP-Seq_MCF-7_Human1.15508543
105SPI1_26923725_Chip-Seq_HPCs_Mouse1.14312444
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14304962
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13959388
108SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13878139
109RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13340330
110NFE2_27457419_Chip-Seq_LIVER_Mouse1.13176159
111PHF8_20622853_ChIP-Seq_HELA_Human1.12776746
112RUNX1_26923725_Chip-Seq_HPCs_Mouse1.11873017
113PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11485036
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11423006
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11423006
116MYC_27129775_Chip-Seq_CORNEA_Mouse1.11290347
117NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10475914
118KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10446751
119RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10104516
120TET1_21451524_ChIP-Seq_MESCs_Mouse1.09998406
121RUNX2_22187159_ChIP-Seq_PCA_Human1.08032861
122GATA6_21074721_ChIP-Seq_CACO-2_Human1.07789009
123JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.07530255
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07338834
125GATA1_19941827_ChIP-Seq_MEL86_Mouse1.07157202
126SMRT_27268052_Chip-Seq_Bcells_Human1.05559661
127ERG_20517297_ChIP-Seq_VCAP_Human1.05520379
128RARA_24833708_ChIP-Seq_LIVER_Mouse1.05094329
129PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.03822898
130NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03461463
131ESET_19884257_ChIP-Seq_ESCs_Mouse1.03285063
132SA1_27219007_Chip-Seq_Bcells_Human1.03116124
133TAF15_26573619_Chip-Seq_HEK293_Human1.03093287
134SMAD4_21799915_ChIP-Seq_A2780_Human1.02923392
135CRX_20693478_ChIP-Seq_RETINA_Mouse1.02535228
136EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01845083
137YY1_22570637_ChIP-Seq_MALME-3M_Human1.01843682
138EZH2_27294783_Chip-Seq_ESCs_Mouse1.01445018
139PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01320872
140STAT3_23295773_ChIP-Seq_U87_Human1.00584822
141NANOG_19829295_ChIP-Seq_ESCs_Human1.00531365
142SOX2_19829295_ChIP-Seq_ESCs_Human1.00531365
143NFYA_21822215_ChIP-Seq_K562_Human1.00437539
144SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00310645
145TCF4_18268006_ChIP-ChIP_LS174T_Human0.99865435
146TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99758738
147SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99736623
148KLF5_25053715_ChIP-Seq_YYC3_Human0.99520473
149CTCF_20526341_ChIP-Seq_ESCs_Human0.99492366
150NANOG_18555785_Chip-Seq_ESCs_Mouse0.98757374
151PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98485772
152CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98476777
153LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97482706
154PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96021539
155SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94840973
156SOX11_22085726_ChIP-Seq_ESNs_Mouse0.94629983
157ELF1_20517297_ChIP-Seq_JURKAT_Human0.92946460
158FLI1_21867929_ChIP-Seq_CD8_Mouse0.92781767
159BCOR_27268052_Chip-Seq_Bcells_Human0.90765533
160OCT4_18555785_Chip-Seq_ESCs_Mouse0.90683514
161NFYB_21822215_ChIP-Seq_K562_Human0.90260002
162KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89083924
163NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.88969310
164P53_22387025_ChIP-Seq_ESCs_Mouse0.88712377
165SMC3_22415368_ChIP-Seq_MEFs_Mouse0.88053107
166NANOG_20526341_ChIP-Seq_ESCs_Human0.87810297
167SOX2_21211035_ChIP-Seq_LN229_Human0.86954391
168ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86675421
169GF1B_26923725_Chip-Seq_HPCs_Mouse0.86553438

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.03569069
2MP0001929_abnormal_gametogenesis5.48859095
3MP0008877_abnormal_DNA_methylation3.75198702
4MP0001348_abnormal_lacrimal_gland3.74373049
5MP0002161_abnormal_fertility/fecundity3.29817140
6MP0002210_abnormal_sex_determination3.24468613
7MP0005670_abnormal_white_adipose3.17064150
8MP0001145_abnormal_male_reproductive2.76240406
9MP0000678_abnormal_parathyroid_gland2.49150542
10MP0003718_maternal_effect2.40952272
11MP0000653_abnormal_sex_gland2.38851348
12MP0002653_abnormal_ependyma_morphology2.32232622
13MP0005410_abnormal_fertilization16.7593796
14MP0002132_abnormal_respiratory_system1.87184705
15MP0005379_endocrine/exocrine_gland_phen1.79191013
16MP0002249_abnormal_larynx_morphology1.72408768
17MP0004233_abnormal_muscle_weight1.65270437
18MP0001486_abnormal_startle_reflex1.60472268
19MP0001485_abnormal_pinna_reflex1.59181228
20MP0003646_muscle_fatigue1.52554458
21MP0004510_myositis1.52532960
22MP0005310_abnormal_salivary_gland1.52276908
23MP0002160_abnormal_reproductive_system1.51837912
24MP0005248_abnormal_Harderian_gland1.50773526
25MP0009053_abnormal_anal_canal1.39853850
26MP0002138_abnormal_hepatobiliary_system1.22849804
27MP0005451_abnormal_body_composition1.17813023
28MP0001984_abnormal_olfaction1.14388659
29MP0005623_abnormal_meninges_morphology1.13546831
30MP0002735_abnormal_chemical_nociception1.13268411
31MP0002234_abnormal_pharynx_morphology1.12737538
32MP0005395_other_phenotype1.12603161
33MP0001963_abnormal_hearing_physiology1.12475312
34MP0004859_abnormal_synaptic_plasticity1.12048932
35MP0002282_abnormal_trachea_morphology1.09566019
36MP0001765_abnormal_ion_homeostasis1.09222675
37MP0002127_abnormal_cardiovascular_syste1.06904608
38MP0000026_abnormal_inner_ear0.98496130
39MP0000681_abnormal_thyroid_gland0.85701983
40MP0000955_abnormal_spinal_cord0.80639392
41MP0005647_abnormal_sex_gland0.78801354
42MP0005083_abnormal_biliary_tract0.78343129
43MP0003115_abnormal_respiratory_system0.77327340
44MP0001879_abnormal_lymphatic_vessel0.76508695
45MP0000049_abnormal_middle_ear0.76023742
46MP0009046_muscle_twitch0.75237674
47MP0008995_early_reproductive_senescence0.75159466
48MP0002067_abnormal_sensory_capabilities0.73261432
49MP0005389_reproductive_system_phenotype0.73237041
50MP0004085_abnormal_heartbeat0.72871560
51MP0002733_abnormal_thermal_nociception0.70870040
52MP0005167_abnormal_blood-brain_barrier0.69449687
53MP0003011_delayed_dark_adaptation0.67634782
54MP0002822_catalepsy0.67476840
55MP0009697_abnormal_copulation0.66058953
56MP0008058_abnormal_DNA_repair0.64294866
57MP0005636_abnormal_mineral_homeostasis0.62347739
58MP0005666_abnormal_adipose_tissue0.61740258
59MP0002557_abnormal_social/conspecific_i0.60628258
60MP0003329_amyloid_beta_deposits0.59701003
61MP0005367_renal/urinary_system_phenotyp0.58839365
62MP0000516_abnormal_urinary_system0.58839365
63MP0004484_altered_response_of0.56906810
64MP0001666_abnormal_nutrient_absorption0.55852883
65MP0005377_hearing/vestibular/ear_phenot0.53569776
66MP0003878_abnormal_ear_physiology0.53569776
67MP0002269_muscular_atrophy0.52581102
68MP0001324_abnormal_eye_pigmentation0.50671562
69MP0000003_abnormal_adipose_tissue0.50671507
70MP0002736_abnormal_nociception_after0.50283076
71MP0003077_abnormal_cell_cycle0.50000720
72MP0001764_abnormal_homeostasis0.49804652
73MP0003880_abnormal_central_pattern0.49727607
74MP0004036_abnormal_muscle_relaxation0.48285808
75MP0000534_abnormal_ureter_morphology0.46744744
76MP0005408_hypopigmentation0.45789899
77MP0000230_abnormal_systemic_arterial0.45280446
78MP0002272_abnormal_nervous_system0.44969061
79MP0003699_abnormal_female_reproductive0.44952338
80MP0001970_abnormal_pain_threshold0.44167479
81MP0001501_abnormal_sleep_pattern0.42991218
82MP0003137_abnormal_impulse_conducting0.42894082
83MP0000358_abnormal_cell_content/0.42739800
84MP0002734_abnormal_mechanical_nocicepti0.42557176
85MP0000613_abnormal_salivary_gland0.42035422
86MP0002928_abnormal_bile_duct0.41383760
87MP0000249_abnormal_blood_vessel0.41202663
88MP0002139_abnormal_hepatobiliary_system0.40351870
89MP0001905_abnormal_dopamine_level0.39320653
90MP0005551_abnormal_eye_electrophysiolog0.39093076
91MP0001293_anophthalmia0.39056274
92MP0006036_abnormal_mitochondrial_physio0.38934514
93MP0004084_abnormal_cardiac_muscle0.38882077
94MP0000470_abnormal_stomach_morphology0.38324301
95MP0009745_abnormal_behavioral_response0.38074255
96MP0005253_abnormal_eye_physiology0.37726252
97MP0003119_abnormal_digestive_system0.37660837
98MP0005595_abnormal_vascular_smooth0.37185939
99MP0000566_synostosis0.37122184
100MP0001440_abnormal_grooming_behavior0.36019092
101MP0009278_abnormal_bone_marrow0.35313724
102MP0005084_abnormal_gallbladder_morpholo0.34890241
103MP0005397_hematopoietic_system_phenotyp0.34322671
104MP0001545_abnormal_hematopoietic_system0.34322671
105MP0004811_abnormal_neuron_physiology0.34276246
106MP0009115_abnormal_fat_cell0.34258191
107MP0003942_abnormal_urinary_system0.33953795
108MP0002932_abnormal_joint_morphology0.33926647
109MP0000569_abnormal_digit_pigmentation0.33884296
110MP0003936_abnormal_reproductive_system0.33129182
111MP0004133_heterotaxia0.31926446
112MP0002102_abnormal_ear_morphology0.31138780
113MP0000604_amyloidosis0.31022977
114MP0001968_abnormal_touch/_nociception0.30650595
115MP0003633_abnormal_nervous_system0.29841583
116MP0010094_abnormal_chromosome_stability0.28217545
117MP0002971_abnormal_brown_adipose0.27701748
118MP0003861_abnormal_nervous_system0.27657985
119MP0005365_abnormal_bile_salt0.27022962
120MP0005391_vision/eye_phenotype0.26528944
121MP0002152_abnormal_brain_morphology0.25927268
122MP0003879_abnormal_hair_cell0.25752742
123MP0001730_embryonic_growth_arrest0.25368167
124MP0003950_abnormal_plasma_membrane0.24407589
125MP0002169_no_abnormal_phenotype0.22999086
126MP0004270_analgesia0.22887552
127MP0003631_nervous_system_phenotype0.22853347
128MP0008961_abnormal_basal_metabolism0.22847809
129MP0002873_normal_phenotype0.22766014
130MP0006035_abnormal_mitochondrial_morpho0.22346889
131MP0001849_ear_inflammation0.21849737
132MP0003948_abnormal_gas_homeostasis0.21685781
133MP0008875_abnormal_xenobiotic_pharmacok0.21513506
134MP0001119_abnormal_female_reproductive0.21381048
135MP0004742_abnormal_vestibular_system0.21313727
136MP0004019_abnormal_vitamin_homeostasis0.20420326
137MP0003111_abnormal_nucleus_morphology0.19026404
138MP0002295_abnormal_pulmonary_circulatio0.18279592
139MP0001661_extended_life_span0.17749356
140MP0002909_abnormal_adrenal_gland0.17566870
141MP0005375_adipose_tissue_phenotype0.17427219
142MP0004145_abnormal_muscle_electrophysio0.15944572
143MP0008569_lethality_at_weaning0.15780711
144MP0004043_abnormal_pH_regulation0.15499639
145MP0002229_neurodegeneration0.15495834
146MP0002118_abnormal_lipid_homeostasis0.15407028
147MP0005423_abnormal_somatic_nervous0.14512220
148MP0005535_abnormal_body_temperature0.14371400
149MP0003959_abnormal_lean_body0.14120930
150MP0000001_mammalian_phenotype0.14120209
151MP0002693_abnormal_pancreas_physiology0.13755535
152MP0005319_abnormal_enzyme/_coenzyme0.13142787
153MP0002572_abnormal_emotion/affect_behav0.12367099
154MP0000751_myopathy0.12337780
155MP0003786_premature_aging0.12305617
156MP0003787_abnormal_imprinting0.12203655
157MP0000462_abnormal_digestive_system0.11920218
158MP0002084_abnormal_developmental_patter0.11817283
159MP0001986_abnormal_taste_sensitivity0.11473424

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.33055895
2Abnormal respiratory motile cilium morphology (HP:0005938)9.33055895
3Abnormal respiratory motile cilium physiology (HP:0012261)9.27953272
4Severe visual impairment (HP:0001141)8.16823505
5Rhinitis (HP:0012384)7.41119113
6Chronic bronchitis (HP:0004469)7.38165951
7Abnormal ciliary motility (HP:0012262)7.20162417
8Infertility (HP:0000789)7.14031121
9Nasal polyposis (HP:0100582)6.41735020
10Abnormality of the nasal mucosa (HP:0000433)5.27086334
11Attenuation of retinal blood vessels (HP:0007843)4.96826552
12Bony spicule pigmentary retinopathy (HP:0007737)4.93268532
13Male infertility (HP:0003251)4.92596851
14Chronic hepatic failure (HP:0100626)4.86447589
15Resting tremor (HP:0002322)4.56623558
16Bronchitis (HP:0012387)4.56238926
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.40409903
18Bronchiectasis (HP:0002110)4.38050217
19Hyperkalemia (HP:0002153)4.29706785
20Cone-rod dystrophy (HP:0000548)4.11924424
21Abnormality of macular pigmentation (HP:0008002)3.99698087
22Nephronophthisis (HP:0000090)3.93514605
23Hypoplastic ischia (HP:0003175)3.78456194
24Abnormal spermatogenesis (HP:0008669)3.76800130
25Potter facies (HP:0002009)3.75468347
26Facial shape deformation (HP:0011334)3.75468347
27Abnormal rod and cone electroretinograms (HP:0008323)3.74088785
28Aplasia/Hypoplasia of the earlobes (HP:0009906)3.68934199
29Enlarged epiphyses (HP:0010580)3.67830004
30Abnormality of the ischium (HP:0003174)3.40226917
31Progressive sensorineural hearing impairment (HP:0000408)3.33629405
32Recurrent otitis media (HP:0000403)3.26231909
33Recurrent sinusitis (HP:0011108)3.17492405
34Hypoplasia of the thymus (HP:0000778)3.16471264
35Hypoalphalipoproteinemia (HP:0003233)3.14060658
36Postural instability (HP:0002172)3.02232334
37Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.00160259
38Unilateral renal agenesis (HP:0000122)2.99042215
39Amelogenesis imperfecta (HP:0000705)2.96098832
40Abnormality of the renal medulla (HP:0100957)2.93317055
41Impulsivity (HP:0100710)2.81788415
42Abnormality of dental color (HP:0011073)2.79900895
43Menstrual irregularities (HP:0000858)2.74711953
44Renovascular hypertension (HP:0100817)2.70456077
45Progressive cerebellar ataxia (HP:0002073)2.69298844
46Recurrent bronchitis (HP:0002837)2.68287575
47Abnormality of the aortic arch (HP:0012303)2.61777926
48Portal hypertension (HP:0001409)2.60511817
49Tubulointerstitial nephritis (HP:0001970)2.59820267
50Insulin-resistant diabetes mellitus (HP:0000831)2.58556806
51Abnormal gallbladder physiology (HP:0012438)2.57039848
52Cholecystitis (HP:0001082)2.57039848
53Generalized aminoaciduria (HP:0002909)2.56496314
54Medial flaring of the eyebrow (HP:0010747)2.52285790
55Tubular atrophy (HP:0000092)2.49825049
56Abnormality of potassium homeostasis (HP:0011042)2.49398119
57Abnormality of midbrain morphology (HP:0002418)2.45966529
58Molar tooth sign on MRI (HP:0002419)2.45966529
59Ventricular tachycardia (HP:0004756)2.42718465
60Focal segmental glomerulosclerosis (HP:0000097)2.40322686
61Abnormality of the hepatic vasculature (HP:0006707)2.37871540
62Abnormality of the costochondral junction (HP:0000919)2.37507547
63Azoospermia (HP:0000027)2.37372275
64Gonadotropin excess (HP:0000837)2.33582449
65Tubulointerstitial abnormality (HP:0001969)2.30476986
66Osteomalacia (HP:0002749)2.30174395
67Dyschromatopsia (HP:0007641)2.27710460
68Flattened epiphyses (HP:0003071)2.27223161
69Abnormality of the parathyroid morphology (HP:0011766)2.19620914
70Choroideremia (HP:0001139)2.13994488
71Progressive hearing impairment (HP:0001730)2.13670706
72Epiphyseal dysplasia (HP:0002656)2.13499681
73Polyuria (HP:0000103)2.10285573
74Hypophosphatemic rickets (HP:0004912)2.06384549
75Spastic tetraparesis (HP:0001285)2.04942037
76Hyponatremia (HP:0002902)2.04493059
77Absent/shortened dynein arms (HP:0200106)13.4476061
78Dynein arm defect of respiratory motile cilia (HP:0012255)13.4476061
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.8320590
80Abnormality of the epiphysis of the femoral head (HP:0010574)1.99429969
81Intellectual disability, moderate (HP:0002342)1.98989721
82Increased purine levels (HP:0004368)1.97162817
83Hyperuricemia (HP:0002149)1.97162817
84Abnormality of the pubic bones (HP:0003172)1.95612050
85Decreased central vision (HP:0007663)1.95328960
86Tubulointerstitial fibrosis (HP:0005576)1.92812625
87Bradycardia (HP:0001662)1.91879648
88Glomerulosclerosis (HP:0000096)1.91639551
89Myokymia (HP:0002411)1.91051333
90Abnormality of femoral epiphyses (HP:0006499)1.87159338
91Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.87159338
92Widely patent fontanelles and sutures (HP:0004492)1.86543488
93Recurrent pneumonia (HP:0006532)1.84082607
94Double outlet right ventricle (HP:0001719)1.84042820
95Congenital malformation of the right heart (HP:0011723)1.84042820
96Optic nerve hypoplasia (HP:0000609)1.81950328
97Flat capital femoral epiphysis (HP:0003370)1.81270864
98Hemorrhage of the eye (HP:0011885)1.80310711
99Subcapsular cataract (HP:0000523)1.78577165
100Recurrent corneal erosions (HP:0000495)1.78501944
101Heterotopia (HP:0002282)1.77999342
102Abnormal ventriculo-arterial connection (HP:0011563)1.77791305
103Transposition of the great arteries (HP:0001669)1.77791305
104Abnormal connection of the cardiac segments (HP:0011545)1.77791305
105Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77107308
106Neurofibrillary tangles (HP:0002185)1.71701090
107Abnormal drinking behavior (HP:0030082)1.71006372
108Polydipsia (HP:0001959)1.71006372
109Aplasia/Hypoplasia of the lens (HP:0008063)1.68058459
110Stage 5 chronic kidney disease (HP:0003774)1.66800108
111Hypoplasia of the capital femoral epiphysis (HP:0003090)1.66336815
112Bile duct proliferation (HP:0001408)1.63806207
113Abnormal biliary tract physiology (HP:0012439)1.63806207
114Decreased electroretinogram (ERG) amplitude (HP:0000654)1.63531548
115Postaxial foot polydactyly (HP:0001830)1.62594493
116Abnormality of renal excretion (HP:0011036)1.59579507
117Congenital hepatic fibrosis (HP:0002612)1.55941988
118Easy fatigability (HP:0003388)1.52263512
119Bell-shaped thorax (HP:0001591)1.49092134
120Abnormality of the renal cortex (HP:0011035)1.48411712
121Sensory axonal neuropathy (HP:0003390)1.47426388
122Short ribs (HP:0000773)1.45763382
123Congenital primary aphakia (HP:0007707)1.45230486
124Gait imbalance (HP:0002141)1.45192172
125Abnormality of the neuromuscular junction (HP:0003398)1.43997900
126Fatigable weakness (HP:0003473)1.43997900
127Bundle branch block (HP:0011710)1.43212160
128Renal dysplasia (HP:0000110)1.42857963
129Asymmetric septal hypertrophy (HP:0001670)1.42489926
130Oculomotor apraxia (HP:0000657)1.41064377
131Cerebral inclusion bodies (HP:0100314)1.39926583
132Postaxial hand polydactyly (HP:0001162)1.39906591
133Cerebellar dysplasia (HP:0007033)1.39489339
134Exercise-induced myalgia (HP:0003738)1.39083511
135Abnormal urine output (HP:0012590)1.36251633
136Hypercholesterolemia (HP:0003124)1.34960585
137Chronic sinusitis (HP:0011109)1.34467155
138Hemiparesis (HP:0001269)1.33227990
139Abnormality of dentin (HP:0010299)1.32975035
140Facial cleft (HP:0002006)1.32219831
141Myoglobinuria (HP:0002913)1.30778742
142Absent epiphyses (HP:0010577)1.30494849
143Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.30494849
144Deformed sella turcica (HP:0002681)1.29454892
145Abnormality of the dental root (HP:0006486)1.29394609
146Taurodontia (HP:0000679)1.29394609
147Abnormality of permanent molar morphology (HP:0011071)1.29394609
148Loss of speech (HP:0002371)1.28500179
149Constricted visual fields (HP:0001133)1.25669629
150Neoplasm of the heart (HP:0100544)1.24599273
151Retinal dysplasia (HP:0007973)1.23300618
152Abnormality of saccadic eye movements (HP:0000570)1.21674565
153Nephrogenic diabetes insipidus (HP:0009806)1.21664504
154Abnormality of the dental pulp (HP:0006479)1.21537850
155Rhabdomyolysis (HP:0003201)1.19716699
156Fibular hypoplasia (HP:0003038)1.19696136
157Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.19518607
158Cystic liver disease (HP:0006706)1.19415170
159Decreased muscle mass (HP:0003199)1.19331947
160Type 2 muscle fiber atrophy (HP:0003554)1.19023012
161Truncal obesity (HP:0001956)1.18817167
162Abnormality of molar (HP:0011077)1.18174333
163Abnormality of molar morphology (HP:0011070)1.18174333
164Generalized muscle weakness (HP:0003324)1.18077597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.61118902
2PDK37.61118902
3TESK17.05568857
4PRKD35.59107518
5ICK5.02123750
6PDK24.90563128
7DDR24.64946180
8INSRR4.44244614
9BRD43.65854465
10MAP4K23.57872495
11PLK23.27446130
12PTK2B2.19292712
13WNK42.12987178
14STK392.11702036
15PIK3CG2.08714548
16STK381.99114350
17DYRK1B1.79734781
18MST1R1.72812586
19PNCK1.64907594
20NEK21.59005819
21PDK11.27907246
22MAP3K91.27798292
23CDK71.26529938
24KSR21.07991964
25AKT31.04525934
26LATS20.97247966
27TYRO30.96892125
28DYRK30.96547584
29CAMK1D0.91547024
30PDPK10.88363872
31IRAK10.86332017
32MAPK150.84533183
33TESK20.83350943
34RIPK40.80930118
35MAP3K110.78951627
36WNK10.78605714
37PASK0.69626963
38EEF2K0.67814814
39PRKAA20.67485362
40TIE10.66695489
41CCNB10.65050142
42RPS6KA20.62912708
43CHEK20.60513987
44STK30.60066089
45UHMK10.58679984
46MAP2K60.58200289
47MAP2K20.56645933
48PINK10.55660133
49TTK0.54704234
50MAP3K20.54415422
51CAMK10.53566746
52SIK20.52934591
53NTRK20.52551557
54MAP3K80.52284046
55LATS10.51711155
56LMTK20.49598435
57IRAK20.49179124
58CDK30.48548807
59ROCK10.48218246
60MUSK0.46833209
61MAP3K100.46154014
62CAMK1G0.44413378
63PAK10.40928885
64ARAF0.40685125
65SGK2230.40365552
66SGK4940.40365552
67PRKCG0.40310346
68MAPK10.39139029
69BMPR1B0.38785791
70CAMK40.36545787
71STK38L0.35601219
72MET0.35306451
73CHEK10.34290982
74NTRK30.32372393
75PAK20.28892650
76MARK20.28650211
77RPS6KC10.28637724
78RPS6KL10.28637724
79MAPKAPK50.27409249
80MAP3K40.27321629
81RPS6KA60.26288163
82PAK40.25696793
83CAMKK10.25649596
84SGK10.25463960
85MTOR0.24469630
86PLK40.24198019
87ATM0.24049725
88PRKCZ0.22571686
89MAPK100.22463995
90MAPK140.21763196
91PRKCQ0.20659426
92PRKAA10.19517507
93CDK150.18543980
94NEK60.18447909
95ATR0.17775173
96BRSK20.16381274
97CDK180.16210000
98AKT10.16146986
99MAP3K130.14600050
100TNIK0.14572112
101MAPK110.14469515
102CDK11A0.14008002
103OXSR10.13478007
104BRAF0.13456368
105FER0.13169122
106RPS6KA10.12538204
107SGK20.12474738
108RPS6KB10.12470794
109PRKG20.12312562
110BRSK10.11241860
111CDK140.09989070
112MAP3K70.09509399
113CDK120.09441814
114PRKACB0.09213768
115CHUK0.08663923
116PKN10.08344344
117PLK10.08167217
118BLK0.07883703
119YES10.07858878
120WEE10.07628484
121MAP2K10.07530876
122GSK3B0.06191268
123CSNK2A10.06031782
124CDK60.05739754
125MAPK90.05652605
126CSF1R0.04945143
127STK110.04764540
128SGK30.04395609
129CAMK2A0.04343287
130MARK30.03998474
131PRKCD0.03578851
132PRKACG0.03498088
133PRKG10.03474636
134PAK60.03434832
135STK100.02888293
136PRKCB0.01822340
137PRKCA0.01650012
138EGFR0.01592384
139MAPK80.00830666
140CSNK1D0.00799233
141CDK20.00585884
142PIM10.00452708
143CDK10.00362900
144CLK10.00039237
145PRKACA-0.0388372
146TRIB3-0.0364029
147MARK1-0.0352460
148RPS6KA3-0.0302264
149AURKA-0.0265765
150CDK4-0.0229966
151RIPK1-0.0225747
152CDC7-0.0208284
153MAP3K1-0.0142998
154CSNK2A2-0.0024118
155PDGFRB-0.0021072

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.71181481
2Fatty acid biosynthesis_Homo sapiens_hsa000614.86733880
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.43411102
4Olfactory transduction_Homo sapiens_hsa047403.80708677
5Pyruvate metabolism_Homo sapiens_hsa006203.22524210
6Vitamin B6 metabolism_Homo sapiens_hsa007503.19434522
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.17711069
8Linoleic acid metabolism_Homo sapiens_hsa005913.08212769
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.89452108
10Butanoate metabolism_Homo sapiens_hsa006502.54528719
11Glucagon signaling pathway_Homo sapiens_hsa049222.52502059
12Propanoate metabolism_Homo sapiens_hsa006402.51672905
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.49894733
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.25128604
15Basal transcription factors_Homo sapiens_hsa030222.15676332
16Selenocompound metabolism_Homo sapiens_hsa004502.06248739
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.03542472
18Glycerolipid metabolism_Homo sapiens_hsa005611.97395599
19PPAR signaling pathway_Homo sapiens_hsa033201.97080626
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.86867441
21Type I diabetes mellitus_Homo sapiens_hsa049401.76037539
22Autoimmune thyroid disease_Homo sapiens_hsa053201.74588754
23Allograft rejection_Homo sapiens_hsa053301.74147352
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.73475532
25Fructose and mannose metabolism_Homo sapiens_hsa000511.67846981
26Phenylalanine metabolism_Homo sapiens_hsa003601.67137849
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.65418400
28Type II diabetes mellitus_Homo sapiens_hsa049301.62970799
29Fat digestion and absorption_Homo sapiens_hsa049751.61378238
30Amphetamine addiction_Homo sapiens_hsa050311.57624534
31Mineral absorption_Homo sapiens_hsa049781.57272693
32Graft-versus-host disease_Homo sapiens_hsa053321.57175954
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55674277
34Fatty acid degradation_Homo sapiens_hsa000711.55305584
35Fatty acid metabolism_Homo sapiens_hsa012121.54150736
36Oocyte meiosis_Homo sapiens_hsa041141.52217029
37Pentose phosphate pathway_Homo sapiens_hsa000301.50818453
38Ether lipid metabolism_Homo sapiens_hsa005651.45536909
39Carbon metabolism_Homo sapiens_hsa012001.33574984
40Dorso-ventral axis formation_Homo sapiens_hsa043201.33265629
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.33159014
42Cardiac muscle contraction_Homo sapiens_hsa042601.32678056
43Viral myocarditis_Homo sapiens_hsa054161.30036674
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25818053
45Arginine and proline metabolism_Homo sapiens_hsa003301.24569453
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.12546516
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08848892
48Renin secretion_Homo sapiens_hsa049241.04493989
49Glutathione metabolism_Homo sapiens_hsa004801.01590875
50Hedgehog signaling pathway_Homo sapiens_hsa043401.01119050
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01011593
52Phototransduction_Homo sapiens_hsa047440.97495841
53Arginine biosynthesis_Homo sapiens_hsa002200.95734993
54Antigen processing and presentation_Homo sapiens_hsa046120.95330376
55Fanconi anemia pathway_Homo sapiens_hsa034600.94970022
56Collecting duct acid secretion_Homo sapiens_hsa049660.94704006
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93338819
58Purine metabolism_Homo sapiens_hsa002300.91696098
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90202466
60Insulin secretion_Homo sapiens_hsa049110.90037604
61Influenza A_Homo sapiens_hsa051640.89453807
62Chemical carcinogenesis_Homo sapiens_hsa052040.87386444
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.85875025
64Biosynthesis of amino acids_Homo sapiens_hsa012300.83688136
65Bile secretion_Homo sapiens_hsa049760.83277380
66Huntingtons disease_Homo sapiens_hsa050160.83029556
67mRNA surveillance pathway_Homo sapiens_hsa030150.82088600
68Morphine addiction_Homo sapiens_hsa050320.80737649
69Arachidonic acid metabolism_Homo sapiens_hsa005900.80117565
70Long-term potentiation_Homo sapiens_hsa047200.79367988
71Thyroid hormone synthesis_Homo sapiens_hsa049180.76852411
72Nicotine addiction_Homo sapiens_hsa050330.76092492
73Estrogen signaling pathway_Homo sapiens_hsa049150.74477212
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.71786795
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70414656
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69823023
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69297954
78Tyrosine metabolism_Homo sapiens_hsa003500.67761025
79Systemic lupus erythematosus_Homo sapiens_hsa053220.65632050
80Retinol metabolism_Homo sapiens_hsa008300.65055923
81RNA transport_Homo sapiens_hsa030130.63527874
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59027575
83Pancreatic secretion_Homo sapiens_hsa049720.58701566
84Renin-angiotensin system_Homo sapiens_hsa046140.57047283
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.56856373
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56066257
87Legionellosis_Homo sapiens_hsa051340.55188176
88Salivary secretion_Homo sapiens_hsa049700.54802162
89Synaptic vesicle cycle_Homo sapiens_hsa047210.54150282
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53514471
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50742705
92Protein digestion and absorption_Homo sapiens_hsa049740.49485320
93ABC transporters_Homo sapiens_hsa020100.49171352
94Calcium signaling pathway_Homo sapiens_hsa040200.48895412
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.46571588
96MAPK signaling pathway_Homo sapiens_hsa040100.46037010
97Gastric acid secretion_Homo sapiens_hsa049710.45010009
98Tight junction_Homo sapiens_hsa045300.44648625
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44239897
100Endocytosis_Homo sapiens_hsa041440.43760687
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.43573029
102AMPK signaling pathway_Homo sapiens_hsa041520.43401371
103Serotonergic synapse_Homo sapiens_hsa047260.42755986
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39987767
105ECM-receptor interaction_Homo sapiens_hsa045120.38705469
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38378733
107Acute myeloid leukemia_Homo sapiens_hsa052210.38059189
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37941774
109Sulfur metabolism_Homo sapiens_hsa009200.37520788
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37437019
111VEGF signaling pathway_Homo sapiens_hsa043700.37292913
112Metabolic pathways_Homo sapiens_hsa011000.37223472
113Inositol phosphate metabolism_Homo sapiens_hsa005620.35623487
114Alcoholism_Homo sapiens_hsa050340.35312511
115Cholinergic synapse_Homo sapiens_hsa047250.34025370
116Taste transduction_Homo sapiens_hsa047420.32499268
117Cocaine addiction_Homo sapiens_hsa050300.32446395
118cAMP signaling pathway_Homo sapiens_hsa040240.31790547
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29960862
120Circadian entrainment_Homo sapiens_hsa047130.29461409
121GABAergic synapse_Homo sapiens_hsa047270.28012680
122Oxytocin signaling pathway_Homo sapiens_hsa049210.27754015
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.27064454
124Adherens junction_Homo sapiens_hsa045200.25822397
125Viral carcinogenesis_Homo sapiens_hsa052030.22958982
126Pyrimidine metabolism_Homo sapiens_hsa002400.21869984
127Nitrogen metabolism_Homo sapiens_hsa009100.19257985
128Herpes simplex infection_Homo sapiens_hsa051680.19093779
129Prolactin signaling pathway_Homo sapiens_hsa049170.19075506
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.17217186
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.16564367
132N-Glycan biosynthesis_Homo sapiens_hsa005100.16484043
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.15149215
134Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.14906132
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.14597102
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.11999983
137Basal cell carcinoma_Homo sapiens_hsa052170.11193740
138HIF-1 signaling pathway_Homo sapiens_hsa040660.09961687
139Wnt signaling pathway_Homo sapiens_hsa043100.09281947
140B cell receptor signaling pathway_Homo sapiens_hsa046620.09134760
141Glutamatergic synapse_Homo sapiens_hsa047240.09092197
142Salmonella infection_Homo sapiens_hsa051320.06414782

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