RNF149

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)5.87498025
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.87498025
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.87498025
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.87498025
5modulation by symbiont of host immune response (GO:0052553)5.87498025
6positive regulation by symbiont of host defense response (GO:0052509)5.87498025
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.84789739
8negative regulation of cell killing (GO:0031342)5.84789739
9positive regulation of gamma-delta T cell activation (GO:0046645)5.73877555
10neutrophil activation involved in immune response (GO:0002283)5.45449515
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.90696702
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.84754001
13regulation of B cell receptor signaling pathway (GO:0050855)4.80016586
14hydrogen peroxide biosynthetic process (GO:0050665)4.71840442
15antigen processing and presentation of endogenous antigen (GO:0019883)4.67793094
16positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.62771967
17response to peptidoglycan (GO:0032494)4.52517008
18macrophage activation involved in immune response (GO:0002281)4.36520338
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.34658656
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.28553697
21regulation of gamma-delta T cell activation (GO:0046643)4.19856335
22detection of bacterium (GO:0016045)4.19394007
23respiratory burst (GO:0045730)4.15765487
24reactive oxygen species biosynthetic process (GO:1903409)4.14172750
25negative regulation of lymphocyte mediated immunity (GO:0002707)4.04068706
26superoxide anion generation (GO:0042554)3.99714633
27positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.99178463
28response to interleukin-15 (GO:0070672)3.98030476
29aldehyde catabolic process (GO:0046185)3.90729488
30response to host immune response (GO:0052572)3.87972329
31response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.87972329
32regulation of interferon-beta biosynthetic process (GO:0045357)3.86985100
33regulation of gamma-delta T cell differentiation (GO:0045586)3.77974708
34positive regulation of cellular amide metabolic process (GO:0034250)3.77447836
35positive regulation of chemokine biosynthetic process (GO:0045080)3.76417223
36lipopolysaccharide-mediated signaling pathway (GO:0031663)3.71611457
37positive regulation of interferon-alpha production (GO:0032727)3.71432250
38immunoglobulin mediated immune response (GO:0016064)3.65333076
39negative regulation of T cell mediated immunity (GO:0002710)3.62608861
40detection of molecule of bacterial origin (GO:0032490)3.60553891
41microglial cell activation (GO:0001774)3.59282245
42granulocyte activation (GO:0036230)3.58884284
43cellular response to interleukin-15 (GO:0071350)3.57863099
44regulation of interferon-alpha production (GO:0032647)3.56484948
45production of molecular mediator involved in inflammatory response (GO:0002532)3.54472802
46positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.54368212
47negative regulation of leukocyte mediated immunity (GO:0002704)3.51724522
48negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.50531114
49cellular response to type I interferon (GO:0071357)3.46940808
50type I interferon signaling pathway (GO:0060337)3.46940808
51positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.45569062
52leukocyte migration involved in inflammatory response (GO:0002523)3.45355115
53response to type I interferon (GO:0034340)3.44272065
54neutrophil activation (GO:0042119)3.40475700
55regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.39503422
56response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.36231226
57response to host (GO:0075136)3.36231226
58response to host defenses (GO:0052200)3.36231226
59myeloid leukocyte mediated immunity (GO:0002444)3.35636373
60positive regulation of heat generation (GO:0031652)3.28229375
61regulation of heterotypic cell-cell adhesion (GO:0034114)3.27655142
62regulation of tolerance induction (GO:0002643)3.24126475
63regulation of T cell tolerance induction (GO:0002664)3.22539554
64macrophage activation (GO:0042116)3.22139106
65B cell receptor signaling pathway (GO:0050853)3.18382673
66negative regulation of T-helper cell differentiation (GO:0045623)3.18225345
67negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.18225345
68regulation of cholesterol storage (GO:0010885)3.18149980
69positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.17688894
70low-density lipoprotein particle clearance (GO:0034383)3.15711430
71negative T cell selection (GO:0043383)3.13780440
72regulation of fever generation (GO:0031620)3.13656259
73regulation of mononuclear cell migration (GO:0071675)3.12644642
74germinal center formation (GO:0002467)3.10759774
75negative thymic T cell selection (GO:0045060)3.10662449
76plasma lipoprotein particle clearance (GO:0034381)3.09646866
77natural killer cell mediated cytotoxicity (GO:0042267)3.09391028
78natural killer cell mediated immunity (GO:0002228)3.09391028
79regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.09305228
80myeloid cell activation involved in immune response (GO:0002275)3.08605391
81interferon-gamma-mediated signaling pathway (GO:0060333)3.07857531
82antigen processing and presentation via MHC class Ib (GO:0002475)3.05703443
83negative regulation of lipid storage (GO:0010888)3.00138935
84regulation of B cell differentiation (GO:0045577)2.99842841
85positive regulation of B cell differentiation (GO:0045579)2.99252107
86negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.99250329
87response to protozoan (GO:0001562)2.98823143
88negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.97511537
89regulation of myeloid leukocyte mediated immunity (GO:0002886)2.97298225
90negative regulation of myeloid cell apoptotic process (GO:0033033)2.96609729
91regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.94361424
92regulation of chemokine biosynthetic process (GO:0045073)2.94178084
93response to muramyl dipeptide (GO:0032495)2.93529037
94regulation of regulatory T cell differentiation (GO:0045589)2.93423908
95dendritic cell migration (GO:0036336)2.92890437
96positive regulation of interferon-beta production (GO:0032728)2.92622159
97positive regulation of toll-like receptor signaling pathway (GO:0034123)2.92034260
98myeloid leukocyte activation (GO:0002274)2.90554750
99positive regulation of mast cell degranulation (GO:0043306)2.89876432
100positive regulation of mast cell activation involved in immune response (GO:0033008)2.89876432
101detection of external biotic stimulus (GO:0098581)2.89532907
102leukocyte mediated cytotoxicity (GO:0001909)2.89119733
103peptidyl-glutamic acid carboxylation (GO:0017187)2.88304798
104protein carboxylation (GO:0018214)2.88304798
105detection of other organism (GO:0098543)2.88259998
106cellular extravasation (GO:0045123)2.88025553
107regulation of membrane protein ectodomain proteolysis (GO:0051043)2.87787850
108regulation of interleukin-8 biosynthetic process (GO:0045414)2.87556307
109tolerance induction (GO:0002507)2.87266510
110T cell migration (GO:0072678)2.86811039
111regulation of T-helper 2 cell differentiation (GO:0045628)2.85996659
112regulation of T cell mediated cytotoxicity (GO:0001914)2.84612808
113triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.84559954
114leukocyte degranulation (GO:0043299)2.84141595
115positive thymic T cell selection (GO:0045059)2.83151757
116regulation of alpha-beta T cell proliferation (GO:0046640)2.82923075
117negative regulation of adaptive immune response (GO:0002820)2.80231713
118regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.79993226
119negative regulation of interleukin-12 production (GO:0032695)2.79848723
120negative regulation of cytokine production involved in immune response (GO:0002719)2.78578045
121regulation of leukocyte degranulation (GO:0043300)2.78549760
122leukocyte aggregation (GO:0070486)2.75681699
123positive regulation of mast cell activation (GO:0033005)2.74227173
124T-helper 1 type immune response (GO:0042088)2.73702189
125I-kappaB phosphorylation (GO:0007252)2.72196865
126positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.71329851
127regulation of mast cell degranulation (GO:0043304)2.68638951
128positive regulation of leukocyte degranulation (GO:0043302)2.66514114
129positive regulation of antigen processing and presentation (GO:0002579)2.66319515
130positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.65742044
131cytokine secretion (GO:0050663)2.65590255
132B cell mediated immunity (GO:0019724)2.61597814
133positive regulation of monocyte chemotaxis (GO:0090026)2.59774734
134positive regulation of chemokine production (GO:0032722)2.59653870
135detection of biotic stimulus (GO:0009595)2.59463894
136negative regulation of interleukin-17 production (GO:0032700)2.59315228
137positive regulation of lipid storage (GO:0010884)2.59247091
138positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.55036885
139regulation of mast cell activation involved in immune response (GO:0033006)2.53751607
140positive regulation of nitric oxide biosynthetic process (GO:0045429)2.52197717
141positive regulation of interleukin-6 production (GO:0032755)2.51905745
142phagosome maturation (GO:0090382)2.51735587
143positive regulation of acute inflammatory response (GO:0002675)2.50712289
144regulation of mast cell activation (GO:0033003)2.50520315
145regulation of heat generation (GO:0031650)2.50266306
146neutrophil mediated immunity (GO:0002446)2.49792546
147regulation of dendritic cell antigen processing and presentation (GO:0002604)2.48842984
148acute-phase response (GO:0006953)2.44108014
149positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.43929520
150defense response to protozoan (GO:0042832)2.43769893
151positive regulation of coagulation (GO:0050820)2.43179886
152cell killing (GO:0001906)2.43177102
153positive regulation of blood coagulation (GO:0030194)2.42317248

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.85026554
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.55877671
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.29277673
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.51207186
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.14274632
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.98271111
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.85224537
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.52086096
9RXR_22158963_ChIP-Seq_LIVER_Mouse3.28614503
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.15451195
11EGR1_23403033_ChIP-Seq_LIVER_Mouse3.11203364
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.01261665
13* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.88320711
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.87974284
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.78812682
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.75494245
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.68113284
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.62678551
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.47362084
20* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.45621943
21SCL_19346495_ChIP-Seq_HPC-7_Human2.39905577
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.25059509
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.22475901
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.20197068
25CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.18261545
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.11094911
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.06251522
28EGR1_19374776_ChIP-ChIP_THP-1_Human2.04503227
29* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.00753857
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.94693189
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.89612523
32VDR_21846776_ChIP-Seq_THP-1_Human1.87862623
33PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.87776832
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86503688
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83168524
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81720445
37* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80770975
38* UTX_26944678_Chip-Seq_JUKART_Human1.74808002
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.69172168
40SPI1_23547873_ChIP-Seq_NB4_Human1.64813324
41CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.61336832
42PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.61310036
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.59105082
44* PU_27001747_Chip-Seq_BMDM_Mouse1.58670860
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54487761
46* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.53389881
47VDR_24787735_ChIP-Seq_THP-1_Human1.52870389
48TCF7_22412390_ChIP-Seq_EML_Mouse1.52493734
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51306400
50* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50105056
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47564987
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.47333217
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.47333217
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43723585
55GATA1_19941827_ChIP-Seq_MEL_Mouse1.43247807
56GATA1_22025678_ChIP-Seq_K562_Human1.41606393
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38435175
58MAF_26560356_Chip-Seq_TH2_Human1.37659217
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36392195
60SOX2_20726797_ChIP-Seq_SW620_Human1.36130606
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34621976
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.30165153
63MYC_22102868_ChIP-Seq_BL_Human1.25800218
64* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24356503
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.24242118
66* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20206804
67KDM2B_26808549_Chip-Seq_DND41_Human1.19046756
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18994384
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18206853
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17345030
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14678715
72* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14514367
73VDR_24763502_ChIP-Seq_THP-1_Human1.14366475
74GATA1_19941826_ChIP-Seq_K562_Human1.13834807
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.11841066
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11297744
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10976350
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.09597875
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08108284
80* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07854465
81* GATA2_21666600_ChIP-Seq_HMVEC_Human1.07672886
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07365464
83NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07326922
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04698092
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04305655
86SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04072315
87CLOCK_20551151_ChIP-Seq_293T_Human1.03206354
88* MYB_26560356_Chip-Seq_TH2_Human1.03130736
89* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02468898
90SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02261980
91SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02261980
92SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02079790
93CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01977834
94RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01447677
95ESR1_21235772_ChIP-Seq_MCF-7_Human1.01137638
96GATA2_19941826_ChIP-Seq_K562_Human1.01041711
97* RUNX_20019798_ChIP-Seq_JUKART_Human0.99681271
98EGR1_19032775_ChIP-ChIP_M12_Human0.99586945
99GATA3_26560356_Chip-Seq_TH2_Human0.99067366
100VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98375438
101ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97804962
102* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96936761
103STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96834405
104GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96167626
105RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95025166
106SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94548557
107* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93930387
108GATA4_25053715_ChIP-Seq_YYC3_Human0.93753713
109FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93358533
110* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93298093
111* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93267682
112CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93241772
113TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93239653
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91180503
115* MYB_26560356_Chip-Seq_TH1_Human0.89183988
116* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.88145591
117CJUN_26792858_Chip-Seq_BT549_Human0.87561040
118JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86325444
119CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86038814
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85321967
121SPI1_23127762_ChIP-Seq_K562_Human0.85065170
122NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84851295
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84845527
124SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84293313
125TFEB_21752829_ChIP-Seq_HELA_Human0.83164126
126KDM2B_26808549_Chip-Seq_JURKAT_Human0.82829964
127MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82530379
128CDX2_20551321_ChIP-Seq_CACO-2_Human0.82419752
129ELK3_25401928_ChIP-Seq_HUVEC_Human0.81676530
130PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81091198
131MAF_26560356_Chip-Seq_TH1_Human0.80726927
132SMRT_27268052_Chip-Seq_Bcells_Human0.80338336
133* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.79677069
134GATA1_19941827_ChIP-Seq_MEL86_Mouse0.79613306
135JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76198534
136* GATA3_27048872_Chip-Seq_THYMUS_Human0.74901375
137SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.74554810
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74009065
139* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72140997
140NCOR1_26117541_ChIP-Seq_K562_Human0.68205344
141FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.67640765
142ESR1_20079471_ChIP-ChIP_T-47D_Human0.64362849

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.64743481
2MP0001835_abnormal_antigen_presentation3.36979467
3MP0005058_abnormal_lysosome_morphology3.10844728
4MP0002139_abnormal_hepatobiliary_system3.10396870
5MP0009785_altered_susceptibility_to3.07551941
6MP0003303_peritoneal_inflammation3.05092052
7MP0006082_CNS_inflammation2.95255597
8MP0002419_abnormal_innate_immunity2.81617341
9MP0003724_increased_susceptibility_to2.77600541
10MP0002148_abnormal_hypersensitivity_rea2.70429097
11MP0005360_urolithiasis2.44113757
12MP0005000_abnormal_immune_tolerance2.43257995
13MP0005025_abnormal_response_to2.42662355
14MP0009764_decreased_sensitivity_to2.33427904
15MP0009840_abnormal_foam_cell2.27375459
16MP0003191_abnormal_cellular_cholesterol2.24961862
17MP0003763_abnormal_thymus_physiology2.18658171
18MP0001533_abnormal_skeleton_physiology2.05960623
19MP0003195_calcinosis2.04599250
20MP0002452_abnormal_antigen_presenting1.97156326
21MP0001790_abnormal_immune_system1.96179978
22MP0005387_immune_system_phenotype1.96179978
23MP0005085_abnormal_gallbladder_physiolo1.94759680
24MP0005464_abnormal_platelet_physiology1.92687572
25MP0004510_myositis1.89783330
26MP0002723_abnormal_immune_serum1.83854489
27MP0002398_abnormal_bone_marrow1.79178733
28MP0005365_abnormal_bile_salt1.76865128
29MP0008469_abnormal_protein_level1.75257405
30MP0003075_altered_response_to1.74650288
31MP0000465_gastrointestinal_hemorrhage1.74227977
32MP0003186_abnormal_redox_activity1.74004655
33MP0001845_abnormal_inflammatory_respons1.73618122
34MP0004947_skin_inflammation1.73540531
35MP0004883_abnormal_blood_vessel1.68741154
36MP0001800_abnormal_humoral_immune1.67849944
37MP0005083_abnormal_biliary_tract1.63545365
38MP0000685_abnormal_immune_system1.62958007
39MP0003172_abnormal_lysosome_physiology1.62881749
40MP0002132_abnormal_respiratory_system1.61131277
41MP0000343_altered_response_to1.60861106
42MP0003300_gastrointestinal_ulcer1.59071988
43MP0008875_abnormal_xenobiotic_pharmacok1.57550042
44MP0005166_decreased_susceptibility_to1.57486703
45MP0000604_amyloidosis1.57076901
46MP0005310_abnormal_salivary_gland1.55330041
47MP0002254_reproductive_system_inflammat1.55273445
48MP0003448_altered_tumor_morphology1.55130015
49MP0001853_heart_inflammation1.51495888
50MP0001819_abnormal_immune_cell1.51351669
51MP0002722_abnormal_immune_system1.51036422
52MP0004381_abnormal_hair_follicle1.50465689
53MP0000569_abnormal_digit_pigmentation1.50227545
54MP0003866_abnormal_defecation1.48581597
55MP0002420_abnormal_adaptive_immunity1.47960176
56MP0002006_tumorigenesis1.42156470
57MP0002138_abnormal_hepatobiliary_system1.40770440
58MP0005671_abnormal_response_to1.40741612
59MP0002429_abnormal_blood_cell1.40736662
60MP0010155_abnormal_intestine_physiology1.36630657
61MP0002405_respiratory_system_inflammati1.35726217
62MP0002998_abnormal_bone_remodeling1.35551170
63MP0004782_abnormal_surfactant_physiolog1.33823645
64MP0002396_abnormal_hematopoietic_system1.33614980
65MP0003690_abnormal_glial_cell1.32970064
66MP0005164_abnormal_response_to1.32886326
67MP0005167_abnormal_blood-brain_barrier1.30435527
68MP0000703_abnormal_thymus_morphology1.28824361
69MP0003252_abnormal_bile_duct1.27632286
70MP0005451_abnormal_body_composition1.25885288
71MP0003656_abnormal_erythrocyte_physiolo1.25602988
72MP0010329_abnormal_lipoprotein_level1.21779896
73MP0000609_abnormal_liver_physiology1.18495539
74MP0005319_abnormal_enzyme/_coenzyme1.18116296
75MP0009763_increased_sensitivity_to1.15640924
76MP0008260_abnormal_autophagy1.14906296
77MP0003453_abnormal_keratinocyte_physiol1.13621128
78MP0003705_abnormal_hypodermis_morpholog1.13233898
79MP0005332_abnormal_amino_acid1.12143696
80MP0003806_abnormal_nucleotide_metabolis1.10624788
81MP0002166_altered_tumor_susceptibility1.09556581
82MP0000858_altered_metastatic_potential1.09114264
83MP0009278_abnormal_bone_marrow1.07897559
84MP0003183_abnormal_peptide_metabolism1.04103575
85MP0002277_abnormal_respiratory_mucosa1.04016870
86MP0006054_spinal_hemorrhage1.01555973
87MP0005390_skeleton_phenotype0.98715113
88MP0001666_abnormal_nutrient_absorption0.97249578
89MP0009333_abnormal_splenocyte_physiolog0.95576433
90MP0000716_abnormal_immune_system0.93860767
91MP0002933_joint_inflammation0.92840530
92MP0003221_abnormal_cardiomyocyte_apopto0.91977811
93MP0004019_abnormal_vitamin_homeostasis0.91079807
94MP0002332_abnormal_exercise_endurance0.89770762
95MP0000015_abnormal_ear_pigmentation0.88625751
96MP0005075_abnormal_melanosome_morpholog0.87310815
97MP0008004_abnormal_stomach_pH0.85915228
98MP0002136_abnormal_kidney_physiology0.85527093
99MP0004808_abnormal_hematopoietic_stem0.81979074
100MP0002118_abnormal_lipid_homeostasis0.81013758
101MP0005257_abnormal_intraocular_pressure0.80923257
102MP0001851_eye_inflammation0.80741068
103MP0002295_abnormal_pulmonary_circulatio0.80697390
104MP0005076_abnormal_cell_differentiation0.80580308
105MP0010352_gastrointestinal_tract_polyps0.79389462
106MP0001663_abnormal_digestive_system0.78399546
107MP0005584_abnormal_enzyme/coenzyme_acti0.77437469
108MP0000249_abnormal_blood_vessel0.77406980
109MP0001545_abnormal_hematopoietic_system0.77300600
110MP0005397_hematopoietic_system_phenotyp0.77300600
111MP0009643_abnormal_urine_homeostasis0.76815068
112MP0009765_abnormal_xenobiotic_induced0.76576107
113MP0000598_abnormal_liver_morphology0.76241517
114MP0003045_fibrosis0.76170500
115MP0005174_abnormal_tail_pigmentation0.75654529
116MP0005408_hypopigmentation0.75593190
117MP0003566_abnormal_cell_adhesion0.74282885
118MP0003828_pulmonary_edema0.72869020
119MP0008438_abnormal_cutaneous_collagen0.72802142
120MP0000689_abnormal_spleen_morphology0.72001417
121MP0001873_stomach_inflammation0.71574248
122MP0004484_altered_response_of0.69554221
123MP0002009_preneoplasia0.68530110
124MP0003795_abnormal_bone_structure0.64367153
125MP0003091_abnormal_cell_migration0.62245917
126MP0008874_decreased_physiological_sensi0.60536514
127MP0003787_abnormal_imprinting0.60466780
128MP0005376_homeostasis/metabolism_phenot0.60014628
129MP0001958_emphysema0.56294161

Predicted human phenotypes

RankGene SetZ-score
1Recurrent gram-negative bacterial infections (HP:0005420)6.68974810
2Eczematoid dermatitis (HP:0000976)6.53095394
3Recurrent abscess formation (HP:0002722)6.18295168
4Recurrent bacterial skin infections (HP:0005406)6.13790713
5Abnormality of macrophages (HP:0004311)5.24204374
6Vacuolated lymphocytes (HP:0001922)4.54777512
7Gastrointestinal infarctions (HP:0005244)4.37201504
8Axonal loss (HP:0003447)4.07891116
9Mediastinal lymphadenopathy (HP:0100721)3.92562464
10T lymphocytopenia (HP:0005403)3.92245024
11Keratoconjunctivitis (HP:0001096)3.90898247
12Systemic lupus erythematosus (HP:0002725)3.86708665
13Increased cerebral lipofuscin (HP:0011813)3.85416741
14Recurrent skin infections (HP:0001581)3.79892426
15Abnormality of T cell number (HP:0011839)3.77130847
16Meningitis (HP:0001287)3.73273157
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.72888943
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.72750341
19Stomatitis (HP:0010280)3.71955501
20Disinhibition (HP:0000734)3.67802773
21Myocardial infarction (HP:0001658)3.65991033
22Gingivitis (HP:0000230)3.58916317
23Joint hemorrhage (HP:0005261)3.58899533
24Encephalitis (HP:0002383)3.57280178
25Glomerulonephritis (HP:0000099)3.43076459
26Orchitis (HP:0100796)3.33088959
27Obstructive lung disease (HP:0006536)3.25333352
28Chronic obstructive pulmonary disease (HP:0006510)3.25333352
29Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.19352712
30Arterial thrombosis (HP:0004420)3.19259811
31Myositis (HP:0100614)3.17571803
32Peritonitis (HP:0002586)3.16571308
33Increased IgE level (HP:0003212)3.12535533
34Chest pain (HP:0100749)3.11913926
35Xanthomatosis (HP:0000991)3.11023383
36Autoimmune thrombocytopenia (HP:0001973)3.07782929
37Prolonged partial thromboplastin time (HP:0003645)3.06820001
38Thick nail (HP:0001805)3.05692097
39Optic neuritis (HP:0100653)3.05594000
40Retrobulbar optic neuritis (HP:0100654)3.05594000
41Episodic fever (HP:0001954)3.00568742
42Leukocytosis (HP:0001974)2.96217168
43Elevated erythrocyte sedimentation rate (HP:0003565)2.95040126
44Prolonged bleeding time (HP:0003010)2.93501598
45Complement deficiency (HP:0004431)2.92244086
46Abnormality of T cells (HP:0002843)2.90956432
47Abnormality of aromatic amino acid family metabolism (HP:0004338)2.88327586
48Recurrent fungal infections (HP:0002841)2.88291304
49Urticaria (HP:0001025)2.84235083
50Abnormality of the common coagulation pathway (HP:0010990)2.84159668
51Gangrene (HP:0100758)2.79796889
52Pustule (HP:0200039)2.77707792
53Epistaxis (HP:0000421)2.74802942
54Abnormality of complement system (HP:0005339)2.74296507
55Deep venous thrombosis (HP:0002625)2.72972992
56Prostate neoplasm (HP:0100787)2.72213253
57Hypochromic microcytic anemia (HP:0004840)2.66120065
58Intrahepatic cholestasis (HP:0001406)2.65586782
59Abnormality of monocarboxylic acid metabolism (HP:0010996)2.60568785
60Gingival bleeding (HP:0000225)2.59952306
61Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.59813160
62Dysostosis multiplex (HP:0000943)2.59168239
63Interstitial pulmonary disease (HP:0006530)2.57722772
64Abnormality of glutamine family amino acid metabolism (HP:0010902)2.55451448
65Increased IgM level (HP:0003496)2.52360671
66Inflammation of the large intestine (HP:0002037)2.51687172
67Periodontitis (HP:0000704)2.51434603
68Granulocytopenia (HP:0001913)2.51380981
69Abnormality of liposaccharide metabolism (HP:0010968)2.50437505
70Abnormality of glycosphingolipid metabolism (HP:0004343)2.50437505
71Abnormality of glycolipid metabolism (HP:0010969)2.50437505
72Hypochromic anemia (HP:0001931)2.48790896
73Abnormality of the pleura (HP:0002103)2.47818567
74Nephritis (HP:0000123)2.46549566
75Hematochezia (HP:0002573)2.44933625
76Autoimmune hemolytic anemia (HP:0001890)2.44734035
77Vasculitis (HP:0002633)2.43021387
78Abnormality of the vasculature of the conjunctiva (HP:0008054)2.41638293
79Hyperlipoproteinemia (HP:0010980)2.41426667
80Amyloidosis (HP:0011034)2.41025221
81Gastrointestinal inflammation (HP:0004386)2.39451506
82Basal ganglia calcification (HP:0002135)2.35099353
83Eosinophilia (HP:0001880)2.34441534
84Hepatosplenomegaly (HP:0001433)2.34407988
85Abnormality of the peritoneum (HP:0002585)2.33151776
86Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.33016440
87Nausea (HP:0002018)2.31253338
88Acute hepatic failure (HP:0006554)2.29179047
89Increased serum ferritin (HP:0003281)2.28226811
90Glomerulopathy (HP:0100820)2.26461431
91Urinary glycosaminoglycan excretion (HP:0003541)2.26262426
92Mucopolysacchariduria (HP:0008155)2.26262426
93Abnormality of T cell physiology (HP:0011840)2.25846858
94Osteolytic defects of the phalanges of the hand (HP:0009771)2.25800091
95Osteolytic defects of the hand bones (HP:0009699)2.25800091
96Tetraparesis (HP:0002273)2.25794274
97Subacute progressive viral hepatitis (HP:0006572)2.24480359
98Hypercholesterolemia (HP:0003124)2.24342169
99Sepsis (HP:0100806)2.24077834
100Keratitis (HP:0000491)2.23254317
101Recurrent bronchitis (HP:0002837)2.23097600
102Menorrhagia (HP:0000132)2.22664169
103Hydroxyprolinuria (HP:0003080)2.20785339
104Abnormality of proline metabolism (HP:0010907)2.20785339
105Hypergammaglobulinemia (HP:0010702)2.19214124
106Abnormality of iron homeostasis (HP:0011031)2.15857431
107Epidermoid cyst (HP:0200040)2.15242616
108Bone pain (HP:0002653)2.13066686
109Abnormality of transition element cation homeostasis (HP:0011030)2.12927598
110Slow saccadic eye movements (HP:0000514)2.12355612
111Panhypogammaglobulinemia (HP:0003139)2.12226677
112Esophageal varix (HP:0002040)2.11427948
113Abnormality of the endocardium (HP:0004306)2.10746471
114Microcytic anemia (HP:0001935)2.09102451
115Spontaneous hematomas (HP:0007420)2.08364324
116Recurrent viral infections (HP:0004429)2.08240870
117Pathologic fracture (HP:0002756)2.07931230
118Peripheral demyelination (HP:0011096)2.07139920
119Cellulitis (HP:0100658)2.06642695
120Pulmonary infiltrates (HP:0002113)2.06092027
121Acne (HP:0001061)2.05803881
122Abnormality of polysaccharide metabolism (HP:0011012)2.04797199
123Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04797199
124Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04797199
125Fat malabsorption (HP:0002630)2.04075250
126Upper motor neuron abnormality (HP:0002127)2.03349715
127Abnormality of eosinophils (HP:0001879)2.02953298
128Osteomyelitis (HP:0002754)2.02827196
129Recurrent pneumonia (HP:0006532)2.02354158
130Skin ulcer (HP:0200042)2.01684975
131Hypobetalipoproteinemia (HP:0003563)2.00985355
132Viral hepatitis (HP:0006562)2.00710509
133Chronic mucocutaneous candidiasis (HP:0002728)2.00601304
134Recurrent cutaneous fungal infections (HP:0011370)2.00601304
135Vertigo (HP:0002321)2.00524598
136Keratoconjunctivitis sicca (HP:0001097)2.00024948
137Lymphopenia (HP:0001888)1.99852012
138Colitis (HP:0002583)1.98948861
139Pulmonary embolism (HP:0002204)1.98602624
140Anorexia (HP:0002039)1.98154089
141Conjunctival telangiectasia (HP:0000524)1.97332520
142Polyneuropathy (HP:0001271)1.96154263
143Vascular calcification (HP:0004934)1.95669526
144Abnormality of the pericardium (HP:0001697)1.95558477
145Thrombophlebitis (HP:0004418)1.94596159
146Joint swelling (HP:0001386)1.94446413
147Steatorrhea (HP:0002570)1.92830897
148Abnormality of cells of the lymphoid lineage (HP:0012140)1.92387459
149Loss of speech (HP:0002371)1.91508250
150Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.91130933
151Abnormality of sulfur amino acid metabolism (HP:0004339)1.91018316
152Petechiae (HP:0000967)1.90449428
153Prolonged neonatal jaundice (HP:0006579)1.90136674
154Hemoptysis (HP:0002105)1.89272888
155Premature loss of primary teeth (HP:0006323)1.87321048
156Cheilitis (HP:0100825)1.86287759
157Neoplasm of the tracheobronchial system (HP:0100552)1.80310673
158Chronic otitis media (HP:0000389)1.79774357
159Skin rash (HP:0000988)1.78436183

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.28289699
2PBK4.24873248
3MAP3K143.79222441
4TBK13.21655229
5IRAK43.03689437
6IRAK32.86475113
7BLK2.79509775
8ERN12.71777242
9TYK22.53019802
10GRK62.36856214
11NME22.19215496
12TAOK32.15714732
13IKBKE2.10614438
14JAK32.08336667
15IKBKB2.07880398
16MST41.95359556
17MST1R1.92630731
18PIM21.83054437
19TXK1.71114081
20TNK21.66839650
21ABL21.65542716
22TAOK11.64409669
23KIT1.61503836
24CSK1.60984570
25MAP4K11.60482356
26PRPF4B1.56774337
27JAK11.52591172
28FGR1.39933069
29MAP3K31.37945600
30EPHB11.36160215
31CHUK1.33071841
32MAP3K21.30457914
33RPS6KA41.25933797
34FRK1.21504101
35ZAP701.20717252
36MAP3K111.20374606
37ITK1.16835545
38NEK91.15289167
39KSR21.12755219
40ERBB41.11873774
41MAP2K31.10803431
42MAP3K61.09894470
43SIK31.09605099
44IRAK21.09465495
45IRAK11.07111030
46FGFR41.05628715
47TGFBR21.04210893
48JAK21.02298300
49BMX1.02252287
50LYN1.01637197
51LCK1.00316132
52STK30.97083744
53CSF1R0.95888499
54HCK0.95435046
55RIPK10.95080185
56MATK0.94788051
57NUAK10.92400997
58MET0.90549019
59EGFR0.88496755
60PTK2B0.86647271
61MAP3K50.86612755
62PIM10.85967815
63SYK0.85945296
64MAP3K130.84711581
65TRIB30.82471049
66CAMKK20.81378536
67MARK20.79497359
68YES10.78576909
69TRPM70.77066974
70EIF2AK20.76939613
71PDK10.76816953
72ABL10.76212162
73BMPR20.75403609
74STK40.73238450
75TEC0.71485259
76RAF10.69048989
77STK100.66804840
78CDK60.66613750
79MAP2K60.66342667
80PTK60.64082498
81BTK0.63732848
82PRKCD0.63731600
83MAP2K20.62840217
84FLT30.62703191
85FGFR30.62022562
86PIK3CG0.61638720
87SGK30.61353535
88CLK10.60912693
89MARK30.60519692
90SGK20.59908993
91MAP2K40.59242781
92PRKD20.57635080
93ACVR1B0.55820621
94KSR10.55738678
95DYRK1B0.55005947
96WNK10.54953396
97NLK0.54230821
98HIPK20.54197078
99LRRK20.53531135
100SIK10.53283241
101GRK70.53092127
102EPHA30.52300947
103STK380.51688922
104MAP3K70.50690818
105TESK20.49975328
106GSK3A0.49774035
107MAPK70.49141763
108CAMK1D0.47085166
109STK110.46768067
110PDPK10.46400405
111MAP3K10.46019749
112PDGFRB0.45433200
113CDC42BPA0.44392804
114RPS6KA60.44371700
115BCKDK0.44015424
116TAOK20.43091966
117RET0.42358767
118EIF2AK10.41676307
119EIF2AK30.40144285
120MAPK120.40055538
121MAPKAPK20.39896071
122ARAF0.39776856
123DAPK30.38827072
124PKN20.36299333
125PRKG20.34665931
126RPS6KL10.33562399
127RPS6KC10.33562399
128INSR0.33560697
129DYRK30.32913408
130PRKCQ0.32841446
131FYN0.32565907
132GRK50.32482051
133MOS0.31862903
134FES0.31756475
135LATS10.30953245
136CAMKK10.30406617
137SIK20.29440874
138STK240.27659651

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.85846299
2Leishmaniasis_Homo sapiens_hsa051402.87037749
3Complement and coagulation cascades_Homo sapiens_hsa046102.31820694
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.31174524
5Legionellosis_Homo sapiens_hsa051342.30763098
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.24210862
7Graft-versus-host disease_Homo sapiens_hsa053322.22064112
8Malaria_Homo sapiens_hsa051442.13112596
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.06196627
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.01860289
11Lysosome_Homo sapiens_hsa041421.97082976
12Primary immunodeficiency_Homo sapiens_hsa053401.96400682
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.96356907
14Rheumatoid arthritis_Homo sapiens_hsa053231.95841871
15Osteoclast differentiation_Homo sapiens_hsa043801.90548354
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.89917177
17Pertussis_Homo sapiens_hsa051331.87890897
18Tuberculosis_Homo sapiens_hsa051521.85033167
19Phagosome_Homo sapiens_hsa041451.75076086
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70973161
21T cell receptor signaling pathway_Homo sapiens_hsa046601.70222692
22Arginine biosynthesis_Homo sapiens_hsa002201.67578955
23Steroid biosynthesis_Homo sapiens_hsa001001.66659692
24Histidine metabolism_Homo sapiens_hsa003401.61173708
25TNF signaling pathway_Homo sapiens_hsa046681.54473298
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51172323
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50032869
28Asthma_Homo sapiens_hsa053101.48600182
29Allograft rejection_Homo sapiens_hsa053301.34602298
30Measles_Homo sapiens_hsa051621.31761619
31Other glycan degradation_Homo sapiens_hsa005111.30015467
32Influenza A_Homo sapiens_hsa051641.29323705
33Salmonella infection_Homo sapiens_hsa051321.25338985
34Caffeine metabolism_Homo sapiens_hsa002321.23996352
35Folate biosynthesis_Homo sapiens_hsa007901.23940777
36Viral myocarditis_Homo sapiens_hsa054161.23217908
37Non-small cell lung cancer_Homo sapiens_hsa052231.19537113
38Nitrogen metabolism_Homo sapiens_hsa009101.19022370
39African trypanosomiasis_Homo sapiens_hsa051431.15275368
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14833984
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14641246
42Chemical carcinogenesis_Homo sapiens_hsa052041.12212280
43Peroxisome_Homo sapiens_hsa041461.12086606
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10679747
45Platelet activation_Homo sapiens_hsa046111.10334154
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.09064762
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07979097
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06819880
49Hematopoietic cell lineage_Homo sapiens_hsa046401.06360886
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03249449
51Toxoplasmosis_Homo sapiens_hsa051451.02338769
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00277403
53Pancreatic cancer_Homo sapiens_hsa052120.99970795
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99519549
55Hepatitis C_Homo sapiens_hsa051600.95143476
56PPAR signaling pathway_Homo sapiens_hsa033200.94348218
57Tryptophan metabolism_Homo sapiens_hsa003800.93591511
58Sulfur relay system_Homo sapiens_hsa041220.93430028
59Sulfur metabolism_Homo sapiens_hsa009200.92374479
60Prolactin signaling pathway_Homo sapiens_hsa049170.91732695
61Phenylalanine metabolism_Homo sapiens_hsa003600.90021982
62beta-Alanine metabolism_Homo sapiens_hsa004100.89998728
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89758023
64Amoebiasis_Homo sapiens_hsa051460.89663666
65VEGF signaling pathway_Homo sapiens_hsa043700.89061236
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.88778628
67Chronic myeloid leukemia_Homo sapiens_hsa052200.86133599
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.85932348
69Apoptosis_Homo sapiens_hsa042100.85014557
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84342932
71Shigellosis_Homo sapiens_hsa051310.83343475
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82974179
73Herpes simplex infection_Homo sapiens_hsa051680.82423688
74Type I diabetes mellitus_Homo sapiens_hsa049400.82196981
75Retinol metabolism_Homo sapiens_hsa008300.81534327
76Dorso-ventral axis formation_Homo sapiens_hsa043200.80548026
77B cell receptor signaling pathway_Homo sapiens_hsa046620.80184670
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79305704
79FoxO signaling pathway_Homo sapiens_hsa040680.77509564
80Renal cell carcinoma_Homo sapiens_hsa052110.76318020
81Prion diseases_Homo sapiens_hsa050200.76144495
82Antigen processing and presentation_Homo sapiens_hsa046120.74026868
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.73591438
84Collecting duct acid secretion_Homo sapiens_hsa049660.73582239
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.71666655
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.70595668
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69527861
88Chemokine signaling pathway_Homo sapiens_hsa040620.66759752
89Fatty acid degradation_Homo sapiens_hsa000710.66748185
90Starch and sucrose metabolism_Homo sapiens_hsa005000.66061313
91Endocytosis_Homo sapiens_hsa041440.65766641
92Vitamin digestion and absorption_Homo sapiens_hsa049770.65379771
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63295994
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63199481
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.63122834
96Hepatitis B_Homo sapiens_hsa051610.62119343
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58949482
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58348106
99Viral carcinogenesis_Homo sapiens_hsa052030.58314632
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58148968
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58056363
102Regulation of autophagy_Homo sapiens_hsa041400.57621531
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.57483997
104HIF-1 signaling pathway_Homo sapiens_hsa040660.56417877
105Epstein-Barr virus infection_Homo sapiens_hsa051690.55679615
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55086747
107Endometrial cancer_Homo sapiens_hsa052130.54957775
108Insulin resistance_Homo sapiens_hsa049310.54599391
109Inositol phosphate metabolism_Homo sapiens_hsa005620.53702697
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.53626787
111Tyrosine metabolism_Homo sapiens_hsa003500.53503510
112Mineral absorption_Homo sapiens_hsa049780.52486148
113Arginine and proline metabolism_Homo sapiens_hsa003300.51716974
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50978493
115Selenocompound metabolism_Homo sapiens_hsa004500.50723915
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.50221973
117Notch signaling pathway_Homo sapiens_hsa043300.50052736
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48955149
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48172955
120Fat digestion and absorption_Homo sapiens_hsa049750.47659509
121Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47397841
122mTOR signaling pathway_Homo sapiens_hsa041500.47203106
123GnRH signaling pathway_Homo sapiens_hsa049120.46715737
124Choline metabolism in cancer_Homo sapiens_hsa052310.46672526
125ABC transporters_Homo sapiens_hsa020100.46101951
126Sphingolipid metabolism_Homo sapiens_hsa006000.44906890
127HTLV-I infection_Homo sapiens_hsa051660.42762565
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42227758
129Autoimmune thyroid disease_Homo sapiens_hsa053200.41907552
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41633585
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41444126
132Glutathione metabolism_Homo sapiens_hsa004800.40719922
133Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39355326
134MAPK signaling pathway_Homo sapiens_hsa040100.39244619
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.39117937
136Type II diabetes mellitus_Homo sapiens_hsa049300.38552900
137ErbB signaling pathway_Homo sapiens_hsa040120.37394408
138Prostate cancer_Homo sapiens_hsa052150.35204731
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35043920
140Colorectal cancer_Homo sapiens_hsa052100.34731358
141Acute myeloid leukemia_Homo sapiens_hsa052210.31732881
142SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30213127
143Rap1 signaling pathway_Homo sapiens_hsa040150.29198237
144Fatty acid metabolism_Homo sapiens_hsa012120.28164249

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