RNF157

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.59891835
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.42191424
3locomotory exploration behavior (GO:0035641)5.99953766
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.75736654
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.68930299
6synaptic vesicle exocytosis (GO:0016079)5.62615024
7glutamate secretion (GO:0014047)5.52869345
8vocalization behavior (GO:0071625)5.48800423
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.38367175
10regulation of synaptic vesicle exocytosis (GO:2000300)5.33578890
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.29062967
12regulation of glutamate receptor signaling pathway (GO:1900449)4.96935905
13protein localization to synapse (GO:0035418)4.89206065
14regulation of synaptic vesicle transport (GO:1902803)4.72517437
15exploration behavior (GO:0035640)4.68189944
16neurotransmitter secretion (GO:0007269)4.65145701
17regulation of neuronal synaptic plasticity (GO:0048168)4.62045769
18neuronal action potential propagation (GO:0019227)4.57145033
19layer formation in cerebral cortex (GO:0021819)4.55316870
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.53379650
21neuron cell-cell adhesion (GO:0007158)4.51462976
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.50156594
23regulation of synapse structural plasticity (GO:0051823)4.37317886
24proline transport (GO:0015824)4.16433297
25dendritic spine morphogenesis (GO:0060997)4.14125702
26synaptic transmission, glutamatergic (GO:0035249)4.09999272
27neuromuscular synaptic transmission (GO:0007274)4.09876627
28presynaptic membrane assembly (GO:0097105)4.09081331
29regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.07558575
30neurotransmitter-gated ion channel clustering (GO:0072578)3.99891206
31central nervous system myelination (GO:0022010)3.98542650
32axon ensheathment in central nervous system (GO:0032291)3.98542650
33cellular potassium ion homeostasis (GO:0030007)3.93435175
34glutamate receptor signaling pathway (GO:0007215)3.89552975
35presynaptic membrane organization (GO:0097090)3.88823384
36neuron-neuron synaptic transmission (GO:0007270)3.88706105
37gamma-aminobutyric acid transport (GO:0015812)3.86640220
38long-term memory (GO:0007616)3.85528165
39potassium ion import (GO:0010107)3.83515800
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.82859875
41positive regulation of membrane potential (GO:0045838)3.82458463
42regulation of excitatory postsynaptic membrane potential (GO:0060079)3.75949492
43sodium ion export (GO:0071436)3.75130287
44neurotransmitter transport (GO:0006836)3.74073574
45cerebellar granule cell differentiation (GO:0021707)3.72988384
46activation of protein kinase A activity (GO:0034199)3.67290052
47regulation of synaptic plasticity (GO:0048167)3.63072733
48regulation of voltage-gated calcium channel activity (GO:1901385)3.62145160
49neuromuscular process controlling balance (GO:0050885)3.60079694
50synaptic vesicle endocytosis (GO:0048488)3.59079285
51regulation of postsynaptic membrane potential (GO:0060078)3.57995752
52regulation of neurotransmitter secretion (GO:0046928)3.56282109
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.54643787
54regulation of dendritic spine morphogenesis (GO:0061001)3.52032556
55glycine transport (GO:0015816)3.51467958
56neuron recognition (GO:0008038)3.51263184
57positive regulation of synapse maturation (GO:0090129)3.50192001
58positive regulation of synaptic transmission, GABAergic (GO:0032230)3.47137871
59cerebellar Purkinje cell differentiation (GO:0021702)3.45846386
60regulation of neurotransmitter levels (GO:0001505)3.44912015
61potassium ion homeostasis (GO:0055075)3.44101882
62transmission of nerve impulse (GO:0019226)3.43934737
63regulation of synapse maturation (GO:0090128)3.40745471
64G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.39272280
65auditory behavior (GO:0031223)3.39025810
66positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.38743447
67response to auditory stimulus (GO:0010996)3.37430361
68neuromuscular process controlling posture (GO:0050884)3.35728248
69positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.34934203
70long-term synaptic potentiation (GO:0060291)3.34791147
71positive regulation of neurotransmitter transport (GO:0051590)3.34396022
72dendrite morphogenesis (GO:0048813)3.32893517
73regulation of neurotransmitter transport (GO:0051588)3.29344496
74positive regulation of neurotransmitter secretion (GO:0001956)3.28869294
75cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.28214401
76postsynaptic membrane organization (GO:0001941)3.27348310
77prepulse inhibition (GO:0060134)3.26067865
78axonal fasciculation (GO:0007413)3.25974059
79behavioral response to nicotine (GO:0035095)3.25708205
80regulation of vesicle fusion (GO:0031338)3.25649684
81regulation of synaptic transmission, glutamatergic (GO:0051966)3.25572128
82membrane depolarization during action potential (GO:0086010)3.25032829
83positive regulation of synapse assembly (GO:0051965)3.21719167
84vesicle transport along microtubule (GO:0047496)3.21173937
85positive regulation of dendritic spine morphogenesis (GO:0061003)3.20322245
86positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.20226159
87cell migration in hindbrain (GO:0021535)3.19926152
88mechanosensory behavior (GO:0007638)3.19663855
89primary amino compound metabolic process (GO:1901160)3.17300074
90neuronal ion channel clustering (GO:0045161)3.16265204
91cell communication by electrical coupling (GO:0010644)3.16257263
92membrane depolarization (GO:0051899)3.15789260
93serotonin metabolic process (GO:0042428)3.15228295
94cell differentiation in hindbrain (GO:0021533)3.15203729
95innervation (GO:0060384)3.13777201
96negative regulation of synaptic transmission, GABAergic (GO:0032229)3.13445541
97regulation of ARF protein signal transduction (GO:0032012)3.12775646
98membrane hyperpolarization (GO:0060081)3.10826736
99regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09690259
100L-amino acid import (GO:0043092)3.09334424
101startle response (GO:0001964)3.09116811
102learning (GO:0007612)3.04800868
103neuromuscular process (GO:0050905)3.04303956
104regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.04212293
105gamma-aminobutyric acid signaling pathway (GO:0007214)3.02349238
106positive regulation of synaptic transmission (GO:0050806)3.01784792
107regulation of synaptic transmission (GO:0050804)3.00473628
108social behavior (GO:0035176)3.00247154
109intraspecies interaction between organisms (GO:0051703)3.00247154
110regulation of dendritic spine development (GO:0060998)2.99908510
111dendritic spine organization (GO:0097061)2.99133887
112cellular sodium ion homeostasis (GO:0006883)2.98935085
113synapse assembly (GO:0007416)2.98917473
114synaptic transmission (GO:0007268)2.96847144
115positive regulation of dendritic spine development (GO:0060999)2.96600540
116organelle transport along microtubule (GO:0072384)2.96375406
117neurotransmitter uptake (GO:0001504)2.96280768
118amino acid import (GO:0043090)2.94698119
119regulation of respiratory system process (GO:0044065)2.94427892
120pyrimidine nucleobase catabolic process (GO:0006208)2.93487314
121axon cargo transport (GO:0008088)2.91596881
122negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91465748
123behavioral defense response (GO:0002209)2.91020261
124regulation of respiratory gaseous exchange (GO:0043576)2.90132843
125adult walking behavior (GO:0007628)2.90032185
126establishment of mitochondrion localization (GO:0051654)2.89044874

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.99244207
2GBX2_23144817_ChIP-Seq_PC3_Human3.30322160
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13759385
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11148982
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01618253
6REST_21632747_ChIP-Seq_MESCs_Mouse2.88591524
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.84306793
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76822541
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76822541
10DROSHA_22980978_ChIP-Seq_HELA_Human2.75899903
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67740606
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56750067
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56673364
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56250973
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46606050
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.46395690
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42411780
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.37999372
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32552220
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.29005527
21* RNF2_27304074_Chip-Seq_ESCs_Mouse2.24274066
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.22438219
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.21441633
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.20892392
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.12326997
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.06073377
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.05854647
28AR_21572438_ChIP-Seq_LNCaP_Human2.03510501
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01526123
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76745442
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63745456
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58186771
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.55519690
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.54175760
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43054362
36RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.41881304
37TAF15_26573619_Chip-Seq_HEK293_Human1.41834693
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37438806
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.37076379
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32963160
41SOX2_21211035_ChIP-Seq_LN229_Gbm1.31841045
42NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31236210
43KDM2B_26808549_Chip-Seq_K562_Human1.30208699
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.27050264
45* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26595088
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25834714
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25298372
48AR_19668381_ChIP-Seq_PC3_Human1.25213913
49ZNF274_21170338_ChIP-Seq_K562_Hela1.22492762
50* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21798429
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21083612
52STAT3_23295773_ChIP-Seq_U87_Human1.20792830
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20633488
54P300_19829295_ChIP-Seq_ESCs_Human1.20514890
55* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19403673
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17606480
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.17222250
58RING1B_27294783_Chip-Seq_NPCs_Mouse1.16234561
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15917731
60* AR_25329375_ChIP-Seq_VCAP_Human1.14807269
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14671550
62P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14666618
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14395207
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08115209
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07740607
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07409159
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06561062
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06506002
69YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06360159
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06199744
71IGF1R_20145208_ChIP-Seq_DFB_Human1.04615986
72OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04347818
73* TCF4_23295773_ChIP-Seq_U87_Human1.03732500
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03531273
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.02829639
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02394293
77VDR_22108803_ChIP-Seq_LS180_Human1.01820128
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.01698301
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00796726
80AHR_22903824_ChIP-Seq_MCF-7_Human1.00625039
81SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00606577
82SMAD3_21741376_ChIP-Seq_ESCs_Human0.99822393
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99679311
84RNF2_27304074_Chip-Seq_NSC_Mouse0.98444109
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96474989
86ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96425658
87CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95896845
88BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95622267
89* PRDM14_20953172_ChIP-Seq_ESCs_Human0.94128209
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93120116
91SMAD4_21741376_ChIP-Seq_HESCs_Human0.93106539
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91666579
93OCT4_19829295_ChIP-Seq_ESCs_Human0.91253410
94GATA1_26923725_Chip-Seq_HPCs_Mouse0.90620921
95TET1_21490601_ChIP-Seq_MESCs_Mouse0.89578874
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89153496
97PIAS1_25552417_ChIP-Seq_VCAP_Human0.88315452
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87553533
99SMAD3_21741376_ChIP-Seq_HESCs_Human0.87406325
100PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87237380
101RUNX2_22187159_ChIP-Seq_PCA_Human0.86892455
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86826866
103TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86788212
104TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84918479
105CTCF_27219007_Chip-Seq_Bcells_Human0.84497932
106KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84289865
107DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84107872
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84031747
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84029239
110LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82338667
111SOX9_26525672_Chip-Seq_HEART_Mouse0.82270347
112DPY_21335234_ChIP-Seq_ESCs_Mouse0.81287868
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.80672251
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78313460
115TP53_20018659_ChIP-ChIP_R1E_Mouse0.77999112
116KLF4_19829295_ChIP-Seq_ESCs_Human0.77084444
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.76289963
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.76184732
119KDM2B_26808549_Chip-Seq_REH_Human0.75411614
120HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.73969377

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.92032800
2MP0003880_abnormal_central_pattern4.63750805
3MP0003635_abnormal_synaptic_transmissio4.26596911
4MP0004270_analgesia4.02768565
5MP0009745_abnormal_behavioral_response3.38920216
6MP0002063_abnormal_learning/memory/cond3.38225367
7MP0001968_abnormal_touch/_nociception3.20882764
8MP0002064_seizures3.19349031
9MP0009046_muscle_twitch3.11200623
10MP0005423_abnormal_somatic_nervous3.10335092
11MP0002734_abnormal_mechanical_nocicepti2.84080497
12MP0002572_abnormal_emotion/affect_behav2.76063605
13MP0002822_catalepsy2.75678521
14MP0001486_abnormal_startle_reflex2.62593244
15MP0002272_abnormal_nervous_system2.60428593
16MP0002735_abnormal_chemical_nociception2.52323265
17MP0002736_abnormal_nociception_after2.44109629
18MP0002733_abnormal_thermal_nociception2.20078041
19MP0001501_abnormal_sleep_pattern2.14512013
20MP0004858_abnormal_nervous_system2.11803773
21MP0001970_abnormal_pain_threshold2.09737042
22MP0008569_lethality_at_weaning2.04835493
23MP0009780_abnormal_chondrocyte_physiolo2.01110356
24MP0001440_abnormal_grooming_behavior2.00051313
25MP0004811_abnormal_neuron_physiology1.99281982
26MP0002067_abnormal_sensory_capabilities1.97364273
27MP0002184_abnormal_innervation1.86952238
28MP0000778_abnormal_nervous_system1.86714415
29MP0003329_amyloid_beta_deposits1.83471622
30MP0002557_abnormal_social/conspecific_i1.75700957
31MP0004924_abnormal_behavior1.75630496
32MP0005386_behavior/neurological_phenoty1.75630496
33MP0002909_abnormal_adrenal_gland1.68559900
34MP0006276_abnormal_autonomic_nervous1.68116627
35MP0000955_abnormal_spinal_cord1.67766530
36MP0003787_abnormal_imprinting1.60702449
37MP0004885_abnormal_endolymph1.59170632
38MP0005646_abnormal_pituitary_gland1.56418804
39MP0003879_abnormal_hair_cell1.53722634
40MP0002882_abnormal_neuron_morphology1.52428576
41MP0008877_abnormal_DNA_methylation1.48180601
42MP0000569_abnormal_digit_pigmentation1.45565704
43MP0001984_abnormal_olfaction1.45315788
44MP0002066_abnormal_motor_capabilities/c1.45101874
45MP0006292_abnormal_olfactory_placode1.44398276
46MP0003646_muscle_fatigue1.43360210
47MP0003633_abnormal_nervous_system1.41593531
48MP0005645_abnormal_hypothalamus_physiol1.39175218
49MP0001529_abnormal_vocalization1.23643926
50MP0004147_increased_porphyrin_level1.23073014
51MP0004142_abnormal_muscle_tone1.20471539
52MP0001905_abnormal_dopamine_level1.20291348
53MP0003631_nervous_system_phenotype1.19960548
54MP0001986_abnormal_taste_sensitivity1.19472403
55MP0001502_abnormal_circadian_rhythm1.19133006
56MP0004130_abnormal_muscle_cell1.17167441
57MP0002152_abnormal_brain_morphology1.13810122
58MP0000566_synostosis1.13534478
59MP0003136_yellow_coat_color1.11923161
60MP0002653_abnormal_ependyma_morphology1.11707812
61MP0003122_maternal_imprinting1.10722810
62MP0003123_paternal_imprinting1.10025835
63MP0002229_neurodegeneration1.07897370
64MP0005551_abnormal_eye_electrophysiolog1.04350682
65MP0003121_genomic_imprinting1.00759246
66MP0002102_abnormal_ear_morphology0.99899161
67MP0008872_abnormal_physiological_respon0.95288833
68MP0003634_abnormal_glial_cell0.93684006
69MP0000920_abnormal_myelination0.91844700
70MP0000751_myopathy0.90763381
71MP0005499_abnormal_olfactory_system0.90328452
72MP0005394_taste/olfaction_phenotype0.90328452
73MP0001177_atelectasis0.89944889
74MP0008874_decreased_physiological_sensi0.89450033
75MP0002069_abnormal_eating/drinking_beha0.88468793
76MP0008961_abnormal_basal_metabolism0.88275158
77MP0004742_abnormal_vestibular_system0.88151470
78MP0001188_hyperpigmentation0.87527551
79MP0003075_altered_response_to0.87246050
80MP0003690_abnormal_glial_cell0.85079014
81MP0003632_abnormal_nervous_system0.83667466
82MP0004043_abnormal_pH_regulation0.83542048
83MP0002752_abnormal_somatic_nervous0.81969708
84MP0000604_amyloidosis0.81395709
85MP0005377_hearing/vestibular/ear_phenot0.81138395
86MP0003878_abnormal_ear_physiology0.81138395
87MP0001346_abnormal_lacrimal_gland0.80907737
88MP0000026_abnormal_inner_ear0.79318761
89MP0001963_abnormal_hearing_physiology0.78375143
90MP0004145_abnormal_muscle_electrophysio0.77912156
91MP0003172_abnormal_lysosome_physiology0.74762824
92MP0002090_abnormal_vision0.74746279
93MP0005409_darkened_coat_color0.74301591
94MP0003283_abnormal_digestive_organ0.74164878
95MP0004510_myositis0.72773103
96MP0004085_abnormal_heartbeat0.72596747
97MP0000631_abnormal_neuroendocrine_gland0.70662578
98MP0005535_abnormal_body_temperature0.70596798
99MP0000013_abnormal_adipose_tissue0.68434269
100MP0003938_abnormal_ear_development0.67564086
101MP0005623_abnormal_meninges_morphology0.67520882
102MP0001348_abnormal_lacrimal_gland0.65424144
103MP0002249_abnormal_larynx_morphology0.63917508
104MP0004233_abnormal_muscle_weight0.63355993
105MP0005253_abnormal_eye_physiology0.63350000
106MP0010386_abnormal_urinary_bladder0.63035097
107MP0001299_abnormal_eye_distance/0.60168076
108MP0003861_abnormal_nervous_system0.60094489
109MP0002638_abnormal_pupillary_reflex0.59299032
110MP0003011_delayed_dark_adaptation0.58445471
111MP0002876_abnormal_thyroid_physiology0.58135029
112MP0001485_abnormal_pinna_reflex0.57199455
113MP0001943_abnormal_respiration0.56440142
114MP0010769_abnormal_survival0.56012339
115MP0004484_altered_response_of0.55050143
116MP0003137_abnormal_impulse_conducting0.54711170
117MP0010770_preweaning_lethality0.52647385
118MP0002082_postnatal_lethality0.52647385
119MP0010768_mortality/aging0.52275332
120MP0001664_abnormal_digestion0.51160965
121MP0003956_abnormal_body_size0.50878197
122MP0005167_abnormal_blood-brain_barrier0.50724155

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.34303312
2Focal motor seizures (HP:0011153)7.06273952
3Focal seizures (HP:0007359)5.56062810
4Visual hallucinations (HP:0002367)5.17565540
5Epileptic encephalopathy (HP:0200134)4.57700383
6Febrile seizures (HP:0002373)4.40505956
7Atonic seizures (HP:0010819)4.38833545
8Progressive cerebellar ataxia (HP:0002073)4.26922092
9Action tremor (HP:0002345)4.21110390
10Supranuclear gaze palsy (HP:0000605)4.16797003
11Ankle clonus (HP:0011448)3.93103485
12Absence seizures (HP:0002121)3.86269003
13Generalized tonic-clonic seizures (HP:0002069)3.68102122
14Papilledema (HP:0001085)3.51340904
15Dialeptic seizures (HP:0011146)3.49708140
16Impaired vibration sensation in the lower limbs (HP:0002166)3.44051726
17Urinary bladder sphincter dysfunction (HP:0002839)3.42898150
18Broad-based gait (HP:0002136)3.37247836
19Depression (HP:0000716)3.33475353
20Poor eye contact (HP:0000817)3.32521011
21Mutism (HP:0002300)3.32167874
22Truncal ataxia (HP:0002078)3.15071025
23Gaze-evoked nystagmus (HP:0000640)3.13623607
24Postural instability (HP:0002172)3.11470098
25Urinary urgency (HP:0000012)3.05646068
26Abnormal social behavior (HP:0012433)3.01779495
27Impaired social interactions (HP:0000735)3.01779495
28Cerebral hypomyelination (HP:0006808)3.00429737
29Abnormal eating behavior (HP:0100738)2.94616385
30Dysdiadochokinesis (HP:0002075)2.94393884
31Dysmetria (HP:0001310)2.94108879
32Anxiety (HP:0000739)2.85951727
33Spastic gait (HP:0002064)2.82744510
34Genetic anticipation (HP:0003743)2.82439828
35Abnormality of the lower motor neuron (HP:0002366)2.79894718
36Amblyopia (HP:0000646)2.78182901
37Torticollis (HP:0000473)2.71798167
38Progressive inability to walk (HP:0002505)2.64701487
39Impaired smooth pursuit (HP:0007772)2.64617442
40Insidious onset (HP:0003587)2.64235659
41Termporal pattern (HP:0011008)2.64235659
42Diplopia (HP:0000651)2.59129691
43Abnormality of binocular vision (HP:0011514)2.59129691
44Megalencephaly (HP:0001355)2.56885775
45Stereotypic behavior (HP:0000733)2.53832132
46Bradykinesia (HP:0002067)2.53589024
47Hyperventilation (HP:0002883)2.52757695
48Hemiplegia (HP:0002301)2.49642857
49Focal dystonia (HP:0004373)2.48077052
50Excessive salivation (HP:0003781)2.47533554
51Drooling (HP:0002307)2.47533554
52Intention tremor (HP:0002080)2.46183859
53Abnormality of the corticospinal tract (HP:0002492)2.44959418
54Insomnia (HP:0100785)2.43189244
55Pheochromocytoma (HP:0002666)2.42405322
56Ventricular fibrillation (HP:0001663)2.41303811
57Hemiparesis (HP:0001269)2.41099369
58Neurofibrillary tangles (HP:0002185)2.40419408
59Annular pancreas (HP:0001734)2.40088292
60Scanning speech (HP:0002168)2.38937955
61Pointed chin (HP:0000307)2.37713429
62Limb dystonia (HP:0002451)2.37493910
63Cerebral inclusion bodies (HP:0100314)2.36230388
64Abnormality of ocular smooth pursuit (HP:0000617)2.34815436
65Lower limb muscle weakness (HP:0007340)2.33492837
66Impaired vibratory sensation (HP:0002495)2.28799975
67Fetal akinesia sequence (HP:0001989)2.27669756
68Sleep apnea (HP:0010535)2.25144912
69Craniofacial dystonia (HP:0012179)2.22502874
70Epileptiform EEG discharges (HP:0011182)2.21667939
71Spastic tetraparesis (HP:0001285)2.18739716
72Delusions (HP:0000746)2.17139683
73EEG with generalized epileptiform discharges (HP:0011198)2.17007323
74Amyotrophic lateral sclerosis (HP:0007354)2.16018909
75Dysmetric saccades (HP:0000641)2.14012168
76Absent speech (HP:0001344)2.10624983
77Hypsarrhythmia (HP:0002521)2.10105145
78Optic nerve hypoplasia (HP:0000609)2.08830552
79CNS hypomyelination (HP:0003429)2.04773013
80Inappropriate behavior (HP:0000719)2.04692830
81Tetraplegia (HP:0002445)2.04663489
82Neuroendocrine neoplasm (HP:0100634)2.04069146
83Hyperthyroidism (HP:0000836)2.03759959
84Inability to walk (HP:0002540)2.01272403
85Clonus (HP:0002169)2.00663431
86Polyphagia (HP:0002591)1.98716841
87Apathy (HP:0000741)1.98700350
88Obstructive sleep apnea (HP:0002870)1.98044892
89Unsteady gait (HP:0002317)1.97585501
90Lower limb amyotrophy (HP:0007210)1.95724968
91Agitation (HP:0000713)1.94386161
92Akinesia (HP:0002304)1.94209677
93Status epilepticus (HP:0002133)1.92194384
94Morphological abnormality of the pyramidal tract (HP:0002062)1.91826412
95Generalized myoclonic seizures (HP:0002123)1.90520158
96Spastic tetraplegia (HP:0002510)1.90009980
97Neuronal loss in central nervous system (HP:0002529)1.88758408
98Abnormality of saccadic eye movements (HP:0000570)1.88484857
99Incomplete penetrance (HP:0003829)1.87835518
100Prolonged QT interval (HP:0001657)1.86152215
101Aqueductal stenosis (HP:0002410)1.84904299
102Gait ataxia (HP:0002066)1.84609687
103Muscle fiber inclusion bodies (HP:0100299)1.82095014
104Rigidity (HP:0002063)1.80960872
105Lower limb asymmetry (HP:0100559)1.80858716
106Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80029153
107Resting tremor (HP:0002322)1.80005835
108Neoplasm of the peripheral nervous system (HP:0100007)1.79551617
109Hypoventilation (HP:0002791)1.79492550
110Peripheral hypomyelination (HP:0007182)1.79342190
111Degeneration of the lateral corticospinal tracts (HP:0002314)1.78519313
112Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78519313
113Bundle branch block (HP:0011710)1.77807994
114Rapidly progressive (HP:0003678)1.76680590
115Abnormal EKG (HP:0003115)1.75620367
116Failure to thrive in infancy (HP:0001531)1.75549567
117Blue irides (HP:0000635)1.75065148
118Ankyloglossia (HP:0010296)1.74654158
119Morphological abnormality of the inner ear (HP:0011390)1.71657028
120Abnormality of the aortic arch (HP:0012303)1.71596967
121Protruding tongue (HP:0010808)1.70423021
122Gait imbalance (HP:0002141)1.69386775
123Lissencephaly (HP:0001339)1.68818809
124Muscle hypertrophy of the lower extremities (HP:0008968)1.66384057
125Abnormality of the labia minora (HP:0012880)1.65235000
126Hypoplasia of the corpus callosum (HP:0002079)1.64873693
127Congenital stationary night blindness (HP:0007642)1.64376485
128Myotonia (HP:0002486)1.64074304

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.45324271
2MAP3K94.05404574
3EPHA43.87861232
4MARK13.61060258
5MINK13.01431623
6MAP3K42.99764441
7DAPK22.60106847
8PAK62.43554540
9MAP2K72.41334965
10PRKD32.34471050
11KSR22.21068494
12CAMKK12.12144593
13NTRK22.08566865
14NTRK11.94289029
15MAP3K121.89400833
16MAP2K41.81808754
17RIPK41.64098517
18CDK51.61534237
19OBSCN1.59415030
20SIK21.59187956
21KSR11.57565391
22DAPK11.51293432
23MAPK131.45965106
24PLK21.40380496
25CDK191.38282162
26STK381.35172129
27PRPF4B1.34399505
28CASK1.33501273
29GRK51.27533435
30MAP3K21.27513830
31PHKG21.23795863
32PHKG11.23795863
33FES1.21717469
34UHMK11.20860133
35PRKCG1.19347187
36TAOK11.16690878
37TYRO31.13852746
38LATS21.12593109
39TNIK1.08199465
40PRKCH1.06502939
41ARAF1.04639720
42PNCK1.04439884
43LMTK21.02904093
44RET1.00806954
45SGK4940.99999643
46SGK2230.99999643
47BMPR1B0.99136817
48WNK30.97367082
49CDK180.97189573
50CDK150.95481328
51STK110.94637527
52WNK40.94452589
53CDK140.92642261
54FRK0.91456755
55ALK0.91095778
56CAMKK20.90875329
57MAP3K130.90585399
58DYRK20.88426065
59CAMK10.87349902
60FGFR20.85248824
61SGK20.83762739
62CDK11A0.83760734
63SGK30.83538783
64CAMK2A0.81026365
65TNK20.76255928
66CSNK1G20.75055109
67MARK20.73264235
68PDK10.70427220
69PINK10.68477801
70WNK10.66975514
71SCYL20.66908993
72DYRK1A0.66546227
73RAF10.65918738
74PAK30.65542168
75SGK10.65142291
76BRSK10.63850833
77INSRR0.59787943
78PDPK10.58452627
79NEK10.57783868
80CAMK2B0.57331404
81MAP3K10.55584729
82PRKCZ0.54927635
83PTK2B0.54528038
84CAMK1G0.53043188
85ADRBK20.52504114
86CDC42BPA0.51437839
87OXSR10.50506781
88MAPKAPK50.50212405
89RPS6KA30.48944745
90FYN0.48430589
91MAPK100.47556950
92BMPR20.46943598
93RPS6KA20.46866570
94CAMK2D0.46460310
95CAMK1D0.46299819
96RIPK10.46053397
97MAP2K60.44318177
98SIK30.43466438
99CCNB10.43455239
100CAMK40.42285756
101MAP3K70.41870943
102PRKACA0.41218483
103PRKCE0.39597422
104MAP3K110.39242711
105NEK60.39191861
106PRKAA10.38484450
107LIMK10.36914445
108PRKCQ0.35428766
109DAPK30.35180705
110PRKCB0.34244433
111PRKCA0.34065694
112MAP2K10.33027618
113PRKG10.32771011
114DMPK0.32044396
115ROCK20.31479119
116GSK3B0.31381550
117STK390.30115312
118GRK10.29955506
119MAPK120.29645350
120CAMK2G0.29619585
121MAPK80.28838428
122PKN10.28769874
123ERBB30.28420561

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.42557529
2Nicotine addiction_Homo sapiens_hsa050333.30208521
3Olfactory transduction_Homo sapiens_hsa047402.95586357
4Circadian entrainment_Homo sapiens_hsa047132.60698868
5Long-term potentiation_Homo sapiens_hsa047202.57648149
6GABAergic synapse_Homo sapiens_hsa047272.55807869
7Glutamatergic synapse_Homo sapiens_hsa047242.46231027
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.45123936
9Morphine addiction_Homo sapiens_hsa050322.40143651
10Amphetamine addiction_Homo sapiens_hsa050312.32435584
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.32204824
12Dopaminergic synapse_Homo sapiens_hsa047282.18212388
13Salivary secretion_Homo sapiens_hsa049702.06566203
14Cholinergic synapse_Homo sapiens_hsa047251.99941126
15Insulin secretion_Homo sapiens_hsa049111.95043150
16Gastric acid secretion_Homo sapiens_hsa049711.90949106
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80837542
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71489366
19Oxytocin signaling pathway_Homo sapiens_hsa049211.63208105
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62403107
21Cocaine addiction_Homo sapiens_hsa050301.59048903
22Renin secretion_Homo sapiens_hsa049241.57898123
23Long-term depression_Homo sapiens_hsa047301.56002960
24Taste transduction_Homo sapiens_hsa047421.55685988
25Serotonergic synapse_Homo sapiens_hsa047261.51535956
26GnRH signaling pathway_Homo sapiens_hsa049121.47501133
27Calcium signaling pathway_Homo sapiens_hsa040201.47192457
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40772191
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.38815012
30Gap junction_Homo sapiens_hsa045401.34915213
31Glioma_Homo sapiens_hsa052141.34568353
32Phototransduction_Homo sapiens_hsa047441.24408112
33cAMP signaling pathway_Homo sapiens_hsa040241.23191913
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22890328
35Collecting duct acid secretion_Homo sapiens_hsa049661.22281497
36Type II diabetes mellitus_Homo sapiens_hsa049301.22031486
37Estrogen signaling pathway_Homo sapiens_hsa049151.18599407
38Axon guidance_Homo sapiens_hsa043601.17748422
39ErbB signaling pathway_Homo sapiens_hsa040121.17503991
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09656217
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07700979
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07095706
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05343533
44Melanogenesis_Homo sapiens_hsa049161.04051725
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01049790
46Dorso-ventral axis formation_Homo sapiens_hsa043200.99234088
47Oocyte meiosis_Homo sapiens_hsa041140.98730898
48Butanoate metabolism_Homo sapiens_hsa006500.96292174
49Nitrogen metabolism_Homo sapiens_hsa009100.94396246
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.91823878
51Vitamin B6 metabolism_Homo sapiens_hsa007500.90454099
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.90341762
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85498878
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.84376336
55Alzheimers disease_Homo sapiens_hsa050100.80422535
56Vibrio cholerae infection_Homo sapiens_hsa051100.80098802
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79087103
58MAPK signaling pathway_Homo sapiens_hsa040100.78928549
59Choline metabolism in cancer_Homo sapiens_hsa052310.75992234
60Cardiac muscle contraction_Homo sapiens_hsa042600.75176850
61VEGF signaling pathway_Homo sapiens_hsa043700.73590989
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72780231
63Pancreatic secretion_Homo sapiens_hsa049720.72283861
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71952538
65Thyroid hormone synthesis_Homo sapiens_hsa049180.70495941
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69671796
67Parkinsons disease_Homo sapiens_hsa050120.69531487
68Endometrial cancer_Homo sapiens_hsa052130.67769315
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67750483
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67665109
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67637881
72Oxidative phosphorylation_Homo sapiens_hsa001900.66621982
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66184421
74mTOR signaling pathway_Homo sapiens_hsa041500.65834303
75Dilated cardiomyopathy_Homo sapiens_hsa054140.65108033
76Non-small cell lung cancer_Homo sapiens_hsa052230.65004923
77Endocytosis_Homo sapiens_hsa041440.64741328
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.63830801
79Ras signaling pathway_Homo sapiens_hsa040140.62653919
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.60877198
81Rap1 signaling pathway_Homo sapiens_hsa040150.59740894
82Type I diabetes mellitus_Homo sapiens_hsa049400.59392869
83Alcoholism_Homo sapiens_hsa050340.59384619
84Fatty acid biosynthesis_Homo sapiens_hsa000610.56384121
85Inositol phosphate metabolism_Homo sapiens_hsa005620.54812810
86Glucagon signaling pathway_Homo sapiens_hsa049220.54413009
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52744143
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52317036
89Chemokine signaling pathway_Homo sapiens_hsa040620.52296371
90Renal cell carcinoma_Homo sapiens_hsa052110.51706861
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50731649
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50116573
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48983266
94Insulin signaling pathway_Homo sapiens_hsa049100.48794700
95Arginine and proline metabolism_Homo sapiens_hsa003300.46672218
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46561345
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46198449
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45769135
99Wnt signaling pathway_Homo sapiens_hsa043100.45219278
100Colorectal cancer_Homo sapiens_hsa052100.45134531
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43247046
102Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43166053
103Ovarian steroidogenesis_Homo sapiens_hsa049130.39966065
104Prion diseases_Homo sapiens_hsa050200.39910492
105Prolactin signaling pathway_Homo sapiens_hsa049170.37378536
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34247948
107Bile secretion_Homo sapiens_hsa049760.34069849
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32992205
109Circadian rhythm_Homo sapiens_hsa047100.30807408
110Arginine biosynthesis_Homo sapiens_hsa002200.30217666
111African trypanosomiasis_Homo sapiens_hsa051430.30161408
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.29650273
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29620691
114Platelet activation_Homo sapiens_hsa046110.29044181
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27111920
116AMPK signaling pathway_Homo sapiens_hsa041520.26550494
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24431147
118Regulation of autophagy_Homo sapiens_hsa041400.23936707
119ABC transporters_Homo sapiens_hsa020100.23774524
120beta-Alanine metabolism_Homo sapiens_hsa004100.23166053
121Hippo signaling pathway_Homo sapiens_hsa043900.22507678
122Huntingtons disease_Homo sapiens_hsa050160.22332921

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