RNF165

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Encoded in regions involved in pericentric inversions in patients with bipolar affective disorder. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1branching involved in labyrinthine layer morphogenesis (GO:0060670)8.51902453
2vocalization behavior (GO:0071625)5.77554969
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.70527107
4neuron cell-cell adhesion (GO:0007158)5.47133706
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.42095443
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.39373946
7positive regulation of inositol phosphate biosynthetic process (GO:0060732)5.26778885
8protein localization to synapse (GO:0035418)5.23312387
9regulation of glutamate receptor signaling pathway (GO:1900449)5.06655121
10locomotory exploration behavior (GO:0035641)4.96160970
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.95495259
12dendritic spine morphogenesis (GO:0060997)4.95461447
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.81887426
14synaptic vesicle maturation (GO:0016188)4.77073521
15neuron recognition (GO:0008038)4.74561973
16behavioral response to nicotine (GO:0035095)4.72966391
17synaptic vesicle exocytosis (GO:0016079)4.68976517
18spindle assembly involved in mitosis (GO:0090307)4.64731391
19layer formation in cerebral cortex (GO:0021819)4.63736300
20axonal fasciculation (GO:0007413)4.59762667
21spinal cord development (GO:0021510)4.51599651
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.47515025
23glutamate receptor signaling pathway (GO:0007215)4.45235249
24cell migration in hindbrain (GO:0021535)4.43641859
25postsynaptic membrane organization (GO:0001941)4.41998030
26central nervous system projection neuron axonogenesis (GO:0021952)4.40787774
27synaptic transmission, glutamatergic (GO:0035249)4.38174435
28regulation of synaptic vesicle exocytosis (GO:2000300)4.35626490
29exploration behavior (GO:0035640)4.35382475
30glutamate secretion (GO:0014047)4.31385431
31myelination in peripheral nervous system (GO:0022011)4.29517633
32peripheral nervous system axon ensheathment (GO:0032292)4.29517633
33positive regulation of mitochondrial fission (GO:0090141)4.28090368
34negative regulation of Rho protein signal transduction (GO:0035024)4.27062361
35pyrimidine nucleobase catabolic process (GO:0006208)4.13912981
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.13686594
37positive regulation of synapse maturation (GO:0090129)4.05024119
38prostate gland growth (GO:0060736)3.99223239
39cell proliferation in forebrain (GO:0021846)3.98021450
40regulation of neuronal synaptic plasticity (GO:0048168)3.95399839
41regulation of long-term neuronal synaptic plasticity (GO:0048169)3.95296609
42neuron-neuron synaptic transmission (GO:0007270)3.94230588
43neurotransmitter-gated ion channel clustering (GO:0072578)3.92913384
44positive regulation of dendritic spine morphogenesis (GO:0061003)3.86446909
45presynaptic membrane assembly (GO:0097105)3.86083557
46regulation of synaptic vesicle transport (GO:1902803)3.85294737
47centrosome duplication (GO:0051298)3.84721888
48positive regulation of oligodendrocyte differentiation (GO:0048714)3.76935666
49regulation of dendritic spine morphogenesis (GO:0061001)3.73766923
50lung-associated mesenchyme development (GO:0060484)3.71080532
51dendrite morphogenesis (GO:0048813)3.70692164
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.70397580
53regulation of inositol phosphate biosynthetic process (GO:0010919)3.68910792
54microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.68803553
55regulation of excitatory postsynaptic membrane potential (GO:0060079)3.63978953
56regulation of synapse structural plasticity (GO:0051823)3.63969604
57neurotransmitter secretion (GO:0007269)3.60562253
58positive regulation of membrane potential (GO:0045838)3.59117556
59cerebral cortex radially oriented cell migration (GO:0021799)3.57479932
60long-term memory (GO:0007616)3.56545046
61presynaptic membrane organization (GO:0097090)3.56165079
62regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.52760387
63anterior/posterior axis specification, embryo (GO:0008595)3.51221513
64regulation of postsynaptic membrane potential (GO:0060078)3.51156155
65regulation of synapse maturation (GO:0090128)3.50963531
66central nervous system neuron axonogenesis (GO:0021955)3.50808502
67regulation of cell proliferation involved in kidney development (GO:1901722)3.50088724
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.49477008
69somite development (GO:0061053)3.47420979
70neuronal action potential propagation (GO:0019227)3.46069389
71auditory behavior (GO:0031223)3.45183169
72dendritic spine organization (GO:0097061)3.44814009
73synaptic vesicle endocytosis (GO:0048488)3.43096040
74positive regulation of dendritic spine development (GO:0060999)3.42699877
75positive regulation of synapse assembly (GO:0051965)3.37861410
76regulation of tight junction assembly (GO:2000810)3.35805464
77response to lipoprotein particle (GO:0055094)3.35189592
78positive regulation of neurotransmitter secretion (GO:0001956)3.34194600
79positive regulation of synaptic transmission, GABAergic (GO:0032230)3.33617821
80nucleobase catabolic process (GO:0046113)3.32319891
81innervation (GO:0060384)3.30808414
82transmission of nerve impulse (GO:0019226)3.30745631
83cell differentiation involved in embryonic placenta development (GO:0060706)3.27742759
84limb bud formation (GO:0060174)3.25908353
85synapse assembly (GO:0007416)3.21979127
86regulation of energy homeostasis (GO:2000505)3.21891722
87behavioral defense response (GO:0002209)3.19426703
88behavioral fear response (GO:0001662)3.19426703
89gamma-aminobutyric acid transport (GO:0015812)3.17480196
90regulation of dendritic spine development (GO:0060998)3.17477440
91regulation of synaptic transmission, glutamatergic (GO:0051966)3.17177151
92regulation of vesicle fusion (GO:0031338)3.15492525
93regulation of synaptic plasticity (GO:0048167)3.15408872
94gamma-aminobutyric acid signaling pathway (GO:0007214)3.14572459
95proline transport (GO:0015824)3.14103518
96regulation of neurotransmitter secretion (GO:0046928)3.13727223
97mitochondrial respiratory chain complex I assembly (GO:0032981)3.12510090
98NADH dehydrogenase complex assembly (GO:0010257)3.12510090
99mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.12510090
100cerebellar Purkinje cell differentiation (GO:0021702)3.12203818
101response to auditory stimulus (GO:0010996)3.10080765
102negative regulation of microtubule polymerization (GO:0031115)3.07342271
103negative regulation of telomerase activity (GO:0051974)3.06301659
104regulation of respiratory system process (GO:0044065)3.05211165
105negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04820096
106positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.04111821
107mitochondrion morphogenesis (GO:0070584)3.03701468
108neuromuscular synaptic transmission (GO:0007274)3.03564568
109learning (GO:0007612)3.03384148
110startle response (GO:0001964)3.03378343
111hippocampus development (GO:0021766)3.01550085
112fear response (GO:0042596)3.00870164
113positive regulation of neurotransmitter transport (GO:0051590)3.00798861
114regulation of mitochondrial fission (GO:0090140)3.00347808
115regulation of synapse assembly (GO:0051963)2.99858025
116regulation of synapse organization (GO:0050807)2.98202261
117G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.97113024
118neurotransmitter transport (GO:0006836)2.96641539
119membrane depolarization (GO:0051899)2.96599604
120negative regulation of synaptic transmission, GABAergic (GO:0032229)2.96350359
121cerebellum development (GO:0021549)2.94014330
122cochlea development (GO:0090102)2.93840019
123regulation of collateral sprouting (GO:0048670)2.91306762
124retinal ganglion cell axon guidance (GO:0031290)2.90091566
125membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.89957652
126positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.89801487
127mechanosensory behavior (GO:0007638)2.89149291
128membrane hyperpolarization (GO:0060081)2.89052477
129intraspecies interaction between organisms (GO:0051703)2.88704035
130social behavior (GO:0035176)2.88704035
131axonogenesis (GO:0007409)2.87729807
132regulation of respiratory gaseous exchange (GO:0043576)2.86214746
133thalamus development (GO:0021794)2.86131058
134dentate gyrus development (GO:0021542)2.85792419
135regulation of neurotransmitter transport (GO:0051588)2.85151092
136long-term synaptic potentiation (GO:0060291)2.84824710
137synapse organization (GO:0050808)2.83367368
138mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.83213759
139organ growth (GO:0035265)2.81781267
140regulation of action potential (GO:0098900)2.79749615
141peristalsis (GO:0030432)2.78350894
142calcium-mediated signaling using intracellular calcium source (GO:0035584)2.78167786
143embryonic camera-type eye development (GO:0031076)2.72374055
144establishment of mitochondrion localization (GO:0051654)2.69750139
145peroxisome fission (GO:0016559)2.69170809
146regulation of extent of cell growth (GO:0061387)2.69089320
147inner cell mass cell proliferation (GO:0001833)2.68862452
148negative regulation of mast cell activation (GO:0033004)2.65491932
149negative regulation of astrocyte differentiation (GO:0048712)2.64091042
150sulfation (GO:0051923)2.63813778
151negative regulation of kidney development (GO:0090185)2.63218552
152regulation of oligodendrocyte differentiation (GO:0048713)2.63044421
153regulation of axon extension (GO:0030516)2.61731578
154forebrain neuron differentiation (GO:0021879)2.60249168
155hindbrain development (GO:0030902)2.59847438
156camera-type eye morphogenesis (GO:0048593)2.59029862
157regulation of telomerase activity (GO:0051972)2.57293632
158DNA deamination (GO:0045006)2.57262960
159synaptic transmission, cholinergic (GO:0007271)2.56197724
160protein polyglutamylation (GO:0018095)2.55711131
161urogenital system development (GO:0001655)2.55287867
162negative regulation of purine nucleotide biosynthetic process (GO:1900372)2.54364392
163negative regulation of nucleotide biosynthetic process (GO:0030809)2.54364392
164positive regulation of fatty acid oxidation (GO:0046321)2.53942444
165protein kinase C signaling (GO:0070528)2.51273852
166synapsis (GO:0007129)2.49821553
167neurofilament cytoskeleton organization (GO:0060052)2.48080186
168serine family amino acid catabolic process (GO:0009071)2.46732710
169positive regulation of potassium ion transmembrane transport (GO:1901381)2.44860529

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.87503260
2GBX2_23144817_ChIP-Seq_PC3_Human3.77701307
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.31089930
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05702223
5EZH2_27304074_Chip-Seq_ESCs_Mouse3.02480148
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85884226
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78226127
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78226127
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72331609
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.63804622
11* REST_21632747_ChIP-Seq_MESCs_Mouse2.63368935
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.56440163
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55730045
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.41761496
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41453435
16RNF2_27304074_Chip-Seq_ESCs_Mouse2.35995954
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.34333101
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33873204
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.28382586
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24813167
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24512786
22DROSHA_22980978_ChIP-Seq_HELA_Human2.20167338
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14711730
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.11863106
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11706614
26CBX2_27304074_Chip-Seq_ESCs_Mouse2.03099776
27RARB_27405468_Chip-Seq_BRAIN_Mouse2.01584830
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.99971412
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91101653
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84892290
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.83959761
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.81200209
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77527462
34AR_21572438_ChIP-Seq_LNCaP_Human1.76046293
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72598828
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67666921
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66771492
38TAF15_26573619_Chip-Seq_HEK293_Human1.64538803
39RNF2_27304074_Chip-Seq_NSC_Mouse1.63437649
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62110356
41* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61800687
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55665707
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.52522839
44RING1B_27294783_Chip-Seq_NPCs_Mouse1.49935313
45P300_19829295_ChIP-Seq_ESCs_Human1.48695288
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48644906
47SMAD4_21799915_ChIP-Seq_A2780_Human1.46444810
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.43501134
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.43345595
50ZNF274_21170338_ChIP-Seq_K562_Hela1.43188996
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30896864
52IGF1R_20145208_ChIP-Seq_DFB_Human1.29336393
53FUS_26573619_Chip-Seq_HEK293_Human1.28712812
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28547202
55IRF1_19129219_ChIP-ChIP_H3396_Human1.26663265
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24720966
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.24646708
58RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24142918
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23801397
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20647965
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20647965
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.19815336
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19706052
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19078827
65EWS_26573619_Chip-Seq_HEK293_Human1.19036382
66VDR_22108803_ChIP-Seq_LS180_Human1.18337946
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17826412
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.16540896
69AR_25329375_ChIP-Seq_VCAP_Human1.16219418
70ER_23166858_ChIP-Seq_MCF-7_Human1.15485552
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.14921985
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13463721
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13137603
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13097349
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12337051
76TP53_20018659_ChIP-ChIP_R1E_Mouse1.10971565
77* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10572503
78* AR_19668381_ChIP-Seq_PC3_Human1.09867731
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09560549
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09224424
81STAT3_23295773_ChIP-Seq_U87_Human1.09181677
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08775119
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05982601
84MYC_18940864_ChIP-ChIP_HL60_Human1.04922421
85SOX2_16153702_ChIP-ChIP_HESCs_Human1.04283433
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02141939
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.02082021
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01976606
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01173609
90BCAT_22108803_ChIP-Seq_LS180_Human1.01118907
91TDRD3_21172665_ChIP-Seq_MCF-7_Human1.01050603
92SOX9_26525672_Chip-Seq_HEART_Mouse1.00975569
93TCF4_23295773_ChIP-Seq_U87_Human1.00903784
94RUNX2_22187159_ChIP-Seq_PCA_Human1.00844244
95* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00737976
96* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99789725
97* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98283585
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98005341
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97654828
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97559823
101NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96571182
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96136068
103* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96097111
104STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95933614
105NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95387850
106NANOG_18555785_Chip-Seq_ESCs_Mouse0.95341379
107AHR_22903824_ChIP-Seq_MCF-7_Human0.95281924
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94995091
109FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93748128
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93404306
111JUN_21703547_ChIP-Seq_K562_Human0.92224096
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91965175
113ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91682850
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91616237
115WDR5_24793694_ChIP-Seq_LNCAP_Human0.91188304
116PRDM14_20953172_ChIP-Seq_ESCs_Human0.90517723
117* SMAD4_21741376_ChIP-Seq_HESCs_Human0.90452268
118POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90145237
119* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89612905
120TP53_18474530_ChIP-ChIP_U2OS_Human0.87935942
121SMAD3_21741376_ChIP-Seq_ESCs_Human0.87864362

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.61971972
2MP0003880_abnormal_central_pattern4.94288874
3MP0003635_abnormal_synaptic_transmissio3.58625781
4MP0004270_analgesia3.21615356
5MP0002063_abnormal_learning/memory/cond3.04898705
6MP0005423_abnormal_somatic_nervous3.04468426
7MP0009745_abnormal_behavioral_response2.91471816
8MP0001968_abnormal_touch/_nociception2.68316349
9MP0000778_abnormal_nervous_system2.64895243
10MP0002572_abnormal_emotion/affect_behav2.57596353
11MP0002064_seizures2.54613711
12MP0005670_abnormal_white_adipose2.54291662
13MP0001486_abnormal_startle_reflex2.50108305
14MP0002734_abnormal_mechanical_nocicepti2.42558672
15MP0000516_abnormal_urinary_system2.39678553
16MP0005367_renal/urinary_system_phenotyp2.39678553
17MP0006292_abnormal_olfactory_placode2.37668369
18MP0009046_muscle_twitch2.31577559
19MP0002735_abnormal_chemical_nociception2.26333335
20MP0006276_abnormal_autonomic_nervous2.19280379
21MP0002184_abnormal_innervation2.13915915
22MP0002272_abnormal_nervous_system2.05187297
23MP0002736_abnormal_nociception_after2.01481455
24MP0003787_abnormal_imprinting1.98391255
25MP0002557_abnormal_social/conspecific_i1.90873730
26MP0009053_abnormal_anal_canal1.82816029
27MP0001440_abnormal_grooming_behavior1.81697836
28MP0002733_abnormal_thermal_nociception1.80840598
29MP0002067_abnormal_sensory_capabilities1.79099493
30MP0001188_hyperpigmentation1.78079105
31MP0004811_abnormal_neuron_physiology1.71270313
32MP0002822_catalepsy1.67916550
33MP0001970_abnormal_pain_threshold1.66425318
34MP0001501_abnormal_sleep_pattern1.64658167
35MP0002102_abnormal_ear_morphology1.63269732
36MP0001984_abnormal_olfaction1.62952087
37MP0004858_abnormal_nervous_system1.62003838
38MP0005645_abnormal_hypothalamus_physiol1.60666374
39MP0008877_abnormal_DNA_methylation1.58960740
40MP0000955_abnormal_spinal_cord1.58103112
41MP0000569_abnormal_digit_pigmentation1.54547114
42MP0002882_abnormal_neuron_morphology1.54410646
43MP0005394_taste/olfaction_phenotype1.51181504
44MP0005499_abnormal_olfactory_system1.51181504
45MP0004924_abnormal_behavior1.48476311
46MP0005386_behavior/neurological_phenoty1.48476311
47MP0003937_abnormal_limbs/digits/tail_de1.47323129
48MP0001529_abnormal_vocalization1.43454112
49MP0003879_abnormal_hair_cell1.41625649
50MP0001849_ear_inflammation1.40791162
51MP0000631_abnormal_neuroendocrine_gland1.37965171
52MP0002152_abnormal_brain_morphology1.37287580
53MP0004885_abnormal_endolymph1.35583551
54MP0005646_abnormal_pituitary_gland1.35068874
55MP0008569_lethality_at_weaning1.30078731
56MP0002066_abnormal_motor_capabilities/c1.29580281
57MP0000013_abnormal_adipose_tissue1.27836099
58MP0008789_abnormal_olfactory_epithelium1.27629518
59MP0002160_abnormal_reproductive_system1.27111272
60MP0003122_maternal_imprinting1.26047080
61MP0003693_abnormal_embryo_hatching1.25820625
62MP0004742_abnormal_vestibular_system1.22945787
63MP0009780_abnormal_chondrocyte_physiolo1.21550786
64MP0005409_darkened_coat_color1.20922045
65MP0001905_abnormal_dopamine_level1.20882580
66MP0003861_abnormal_nervous_system1.19671619
67MP0003136_yellow_coat_color1.18790028
68MP0003938_abnormal_ear_development1.16656357
69MP0001502_abnormal_circadian_rhythm1.14666333
70MP0002282_abnormal_trachea_morphology1.14641031
71MP0002751_abnormal_autonomic_nervous1.13942419
72MP0002638_abnormal_pupillary_reflex1.13231111
73MP0002752_abnormal_somatic_nervous1.11262148
74MP0000026_abnormal_inner_ear1.06625225
75MP0004130_abnormal_muscle_cell1.05672275
76MP0004142_abnormal_muscle_tone1.04587299
77MP0005551_abnormal_eye_electrophysiolog1.02687293
78MP0001963_abnormal_hearing_physiology1.00637283
79MP0000534_abnormal_ureter_morphology1.00121753
80MP0002928_abnormal_bile_duct0.99769030
81MP0002909_abnormal_adrenal_gland0.98832086
82MP0003119_abnormal_digestive_system0.98794050
83MP0000566_synostosis0.97835056
84MP0008872_abnormal_physiological_respon0.95252697
85MP0002653_abnormal_ependyma_morphology0.95047205
86MP0000049_abnormal_middle_ear0.94966893
87MP0002876_abnormal_thyroid_physiology0.94683861
88MP0001485_abnormal_pinna_reflex0.93208194
89MP0009250_abnormal_appendicular_skeleto0.92906395
90MP0004133_heterotaxia0.90777915
91MP0002069_abnormal_eating/drinking_beha0.90066066
92MP0003121_genomic_imprinting0.89498692
93MP0002116_abnormal_craniofacial_bone0.88001502
94MP0002234_abnormal_pharynx_morphology0.86726927
95MP0010386_abnormal_urinary_bladder0.86598504
96MP0006072_abnormal_retinal_apoptosis0.86588762
97MP0003890_abnormal_embryonic-extraembry0.83847616
98MP0003942_abnormal_urinary_system0.82371299
99MP0003123_paternal_imprinting0.81719817
100MP0002938_white_spotting0.81685733
101MP0009384_cardiac_valve_regurgitation0.80712378
102MP0003329_amyloid_beta_deposits0.80644229
103MP0004085_abnormal_heartbeat0.75332623
104MP0001293_anophthalmia0.74987518
105MP0005187_abnormal_penis_morphology0.74536935
106MP0000537_abnormal_urethra_morphology0.71809712
107MP0003633_abnormal_nervous_system0.70948328
108MP0002249_abnormal_larynx_morphology0.70635237
109MP0003936_abnormal_reproductive_system0.70567189
110MP0003631_nervous_system_phenotype0.69182689
111MP0002229_neurodegeneration0.68937097
112MP0003137_abnormal_impulse_conducting0.68393762
113MP0002081_perinatal_lethality0.67902861
114MP0003385_abnormal_body_wall0.67863251
115MP0001177_atelectasis0.67779008
116MP0009379_abnormal_foot_pigmentation0.66018351
117MP0004145_abnormal_muscle_electrophysio0.65805232
118MP0003315_abnormal_perineum_morphology0.64884735
119MP0010770_preweaning_lethality0.63075991
120MP0002082_postnatal_lethality0.63075991
121MP0005195_abnormal_posterior_eye0.62953847
122MP0003283_abnormal_digestive_organ0.62845642
123MP0010769_abnormal_survival0.62158366
124MP0005253_abnormal_eye_physiology0.61748684
125MP0008961_abnormal_basal_metabolism0.60638183

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.25079349
2Short 1st metacarpal (HP:0010034)5.42616452
3Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)5.42616452
4Stenosis of the external auditory canal (HP:0000402)5.35890490
5Myokymia (HP:0002411)5.28862989
6Ectopic kidney (HP:0000086)4.94475814
7Abnormality of the 1st metacarpal (HP:0010009)4.74826437
8Focal seizures (HP:0007359)4.62968448
9Epileptic encephalopathy (HP:0200134)4.50614515
10Progressive cerebellar ataxia (HP:0002073)4.03190676
11Carpal bone hypoplasia (HP:0001498)3.99702793
12Febrile seizures (HP:0002373)3.98992370
13Short phalanx of the thumb (HP:0009660)3.83341476
14Visual hallucinations (HP:0002367)3.78824621
15Broad-based gait (HP:0002136)3.61108500
16Absent thumb (HP:0009777)3.60088596
17Abnormality of the parathyroid morphology (HP:0011766)3.54815225
18Amblyopia (HP:0000646)3.50347506
19Duplicated collecting system (HP:0000081)3.46561242
20Abnormality of the renal collecting system (HP:0004742)3.40848773
21Chromosomal breakage induced by crosslinking agents (HP:0003221)3.40744511
22Rectovaginal fistula (HP:0000143)3.25692050
23Rectal fistula (HP:0100590)3.25692050
24Drooling (HP:0002307)3.15947382
25Excessive salivation (HP:0003781)3.15947382
26Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.12153062
27Limb dystonia (HP:0002451)3.09194522
28Hyperventilation (HP:0002883)3.07735515
29Absence seizures (HP:0002121)3.07456223
30Pendular nystagmus (HP:0012043)3.06512953
31Atonic seizures (HP:0010819)3.06312879
32Neoplasm of the oral cavity (HP:0100649)3.01626886
33Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.99770329
34Abnormality of DNA repair (HP:0003254)2.95465075
35Chromsome breakage (HP:0040012)2.95173561
36Absent radius (HP:0003974)2.93584077
37Optic nerve coloboma (HP:0000588)2.92862054
38Generalized tonic-clonic seizures (HP:0002069)2.90589839
39Intestinal fistula (HP:0100819)2.90327343
40Supranuclear gaze palsy (HP:0000605)2.88557627
41Absent forearm bone (HP:0003953)2.88188918
42Aplasia involving forearm bones (HP:0009822)2.88188918
43Dialeptic seizures (HP:0011146)2.85043039
44Short hallux (HP:0010109)2.84690173
45Reticulocytopenia (HP:0001896)2.84589307
46Horseshoe kidney (HP:0000085)2.84407689
47Osteomalacia (HP:0002749)2.83588505
48Fused cervical vertebrae (HP:0002949)2.74940831
49Aplasia/Hypoplasia of the hallux (HP:0008362)2.70828984
50Hemiparesis (HP:0001269)2.68076958
51Vaginal fistula (HP:0004320)2.64859797
52Poor eye contact (HP:0000817)2.64601339
53Gaze-evoked nystagmus (HP:0000640)2.62904516
54Vitreoretinal degeneration (HP:0000655)2.61673570
55Mutism (HP:0002300)2.61575982
56Absent speech (HP:0001344)2.60926074
57Aplasia/Hypoplasia involving the musculature (HP:0001460)2.54234262
58Genetic anticipation (HP:0003743)2.54191674
59Epileptiform EEG discharges (HP:0011182)2.51347117
60Impaired vibration sensation in the lower limbs (HP:0002166)2.49634490
61Synostosis of carpal bones (HP:0005048)2.48397094
62Urinary bladder sphincter dysfunction (HP:0002839)2.47669815
63Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.44343367
64Ankle clonus (HP:0011448)2.40485958
65Abnormality of the carotid arteries (HP:0005344)2.39887781
66EEG with generalized epileptiform discharges (HP:0011198)2.39712811
67Status epilepticus (HP:0002133)2.39671695
68Tachypnea (HP:0002789)2.39238355
69Short thumb (HP:0009778)2.38480121
70Stereotypic behavior (HP:0000733)2.37088832
71Oligomenorrhea (HP:0000876)2.32601328
72Amyotrophic lateral sclerosis (HP:0007354)2.31798602
73Polyphagia (HP:0002591)2.30230427
74Action tremor (HP:0002345)2.29512931
75Hypsarrhythmia (HP:0002521)2.24723616
76Aplasia/Hypoplasia of the uvula (HP:0010293)2.24423912
77Protruding tongue (HP:0010808)2.23964157
78Pancreatic cysts (HP:0001737)2.21715616
79Maternal diabetes (HP:0009800)2.21413811
80Impaired social interactions (HP:0000735)2.18922842
81Abnormal social behavior (HP:0012433)2.18922842
82Abnormal eating behavior (HP:0100738)2.18391815
83Triphalangeal thumb (HP:0001199)2.18100956
84Obstructive sleep apnea (HP:0002870)2.17639934
85Abnormality of salivation (HP:0100755)2.14011074
86Renal hypoplasia (HP:0000089)2.11969507
87Truncal ataxia (HP:0002078)2.11001830
88Choanal stenosis (HP:0000452)2.10701409
89Chorioretinal atrophy (HP:0000533)2.09345508
90Preaxial foot polydactyly (HP:0001841)2.08963826
91Dysdiadochokinesis (HP:0002075)2.08726640
92True hermaphroditism (HP:0010459)2.08577232
93Fetal akinesia sequence (HP:0001989)2.08342120
94Inappropriate behavior (HP:0000719)2.07489193
95Nephronophthisis (HP:0000090)2.07244115
96Gait imbalance (HP:0002141)2.06868452
97Depression (HP:0000716)2.06848240
98Abnormality of the labia minora (HP:0012880)2.06441908
99Lissencephaly (HP:0001339)2.06254476
100Gastroesophageal reflux (HP:0002020)2.05532430
101Impaired smooth pursuit (HP:0007772)2.05280658
102Short humerus (HP:0005792)2.03774402
103Abnormality of the lower motor neuron (HP:0002366)2.02028344
104Aplasia/Hypoplasia of the brainstem (HP:0007362)2.01959661
105Hypoplasia of the brainstem (HP:0002365)2.01959661
106Diplopia (HP:0000651)2.00824127
107Abnormality of binocular vision (HP:0011514)2.00824127
108Pancreatic fibrosis (HP:0100732)1.99970545
109Autism (HP:0000717)1.99331355
110Exotropia (HP:0000577)1.99214507
111Megalencephaly (HP:0001355)1.98325908
112Specific learning disability (HP:0001328)1.98164506
113Abnormality of the corticospinal tract (HP:0002492)1.98126613
114Vertebral fusion (HP:0002948)1.97141255
115Hypoplasia of the ulna (HP:0003022)1.96269105
116Renal agenesis (HP:0000104)1.96182352
117Abnormality of midbrain morphology (HP:0002418)1.94394544
118Molar tooth sign on MRI (HP:0002419)1.94394544
119Aplasia/hypoplasia of the humerus (HP:0006507)1.91443265
120Anal stenosis (HP:0002025)1.90906474
121Dysmetria (HP:0001310)1.90607088
122Morphological abnormality of the middle ear (HP:0008609)1.90252405
123Meckel diverticulum (HP:0002245)1.89692719
124Anxiety (HP:0000739)1.89297465
125Sleep apnea (HP:0010535)1.88458597
126Progressive inability to walk (HP:0002505)1.88250623
127Bony spicule pigmentary retinopathy (HP:0007737)1.87209545
128Abnormality of the ileum (HP:0001549)1.86533727
129Spastic gait (HP:0002064)1.86157472
130Inability to walk (HP:0002540)1.85889684
131Termporal pattern (HP:0011008)1.85723433
132Insidious onset (HP:0003587)1.85723433
133Pachygyria (HP:0001302)1.85282214
134Severe muscular hypotonia (HP:0006829)1.84516136
135Urinary urgency (HP:0000012)1.84107230
136Aqueductal stenosis (HP:0002410)1.83472174
137Agitation (HP:0000713)1.83293983
138Cerebral inclusion bodies (HP:0100314)1.81162684
139Hip dysplasia (HP:0001385)1.80042628
140Duplication of thumb phalanx (HP:0009942)1.79909719
141Congenital stationary night blindness (HP:0007642)1.79733598
142Septo-optic dysplasia (HP:0100842)1.79716492
143Hypoplastic iliac wings (HP:0002866)1.78834802
144Hyperthyroidism (HP:0000836)1.78352170
145Absent/shortened dynein arms (HP:0200106)1.77013738
146Dynein arm defect of respiratory motile cilia (HP:0012255)1.77013738
147Incomplete penetrance (HP:0003829)1.76705420
148Tented upper lip vermilion (HP:0010804)1.76577907
149Aplasia/Hypoplasia of the patella (HP:0006498)1.75811627
150Shoulder girdle muscle weakness (HP:0003547)1.75490754
151Hypoplasia of the thymus (HP:0000778)1.75328790
152Hepatoblastoma (HP:0002884)1.74760610
153Anophthalmia (HP:0000528)1.74737119
154Cutaneous finger syndactyly (HP:0010554)1.73932701
155Increased corneal curvature (HP:0100692)1.73743671
156Keratoconus (HP:0000563)1.73743671
157Focal dystonia (HP:0004373)1.73622794
158Abnormality of ocular smooth pursuit (HP:0000617)1.73609353
159Preaxial hand polydactyly (HP:0001177)1.72924867
160Pointed chin (HP:0000307)1.72381935
161Akinesia (HP:0002304)1.71801956
162Torticollis (HP:0000473)1.71700440
163Neurofibrillary tangles (HP:0002185)1.71106314
164Abolished electroretinogram (ERG) (HP:0000550)1.71035464
165Sporadic (HP:0003745)1.70903803
166Abnormality of the aortic arch (HP:0012303)1.69352162
167Intellectual disability, moderate (HP:0002342)1.69311924
168Abnormal ciliary motility (HP:0012262)1.69129033
169Abnormality of the renal medulla (HP:0100957)1.68914948
170Insomnia (HP:0100785)1.68731077
171Papilledema (HP:0001085)1.68498552
172Truncus arteriosus (HP:0001660)1.68132660
173Abnormal respiratory motile cilium morphology (HP:0005938)1.67965591
174Abnormal respiratory epithelium morphology (HP:0012253)1.67965591
175Postural instability (HP:0002172)1.67536285
176Impaired vibratory sensation (HP:0002495)1.65661875
177Esotropia (HP:0000565)1.64951598
178Thickened helices (HP:0000391)1.60887963
179Generalized myoclonic seizures (HP:0002123)1.58680263
180Oligodactyly (hands) (HP:0001180)1.55326433

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.20950543
2EPHA44.38592060
3NTRK34.23361329
4MAP3K93.06062127
5MAP3K42.97958245
6GRK12.83556182
7CASK2.78171445
8MAP2K72.75465271
9NTRK22.34892109
10MAPK132.34723423
11TNIK2.32881887
12MINK12.31872185
13SIK22.26277340
14FRK2.08981770
15DAPK21.99882074
16KSR11.99512431
17PAK61.95275343
18PRPF4B1.79126469
19PNCK1.76111335
20MAP2K41.63827383
21CDC71.59401088
22PLK21.51609823
23DYRK21.48952105
24CDK91.46871074
25UHMK11.46075522
26BMPR1B1.43625861
27DYRK31.42580314
28PRKD31.41815014
29CDK51.38941950
30DAPK11.37813897
31LATS21.30658804
32TRIM281.30569661
33TLK11.30233551
34EPHB21.21009334
35PHKG21.13367974
36PHKG11.13367974
37PRKCG1.12563077
38ZAK1.11445873
39DYRK1A1.09907853
40MAP3K121.08140078
41FES1.05047809
42PINK11.01118449
43GRK51.01113499
44SIK31.01105720
45KSR20.97388474
46WNK40.97127504
47CDK180.96247902
48CAMKK10.93637003
49STK380.93327668
50RIPK40.93320952
51ERBB30.93100427
52CDK150.92499650
53TYRO30.91003740
54CAMK2A0.90153571
55STK110.88963661
56MAP2K10.87421800
57CDK140.87100822
58NTRK10.85446863
59CSNK1G10.85300996
60NUAK10.83883944
61CSNK1G20.83761766
62MARK20.83025114
63CDK11A0.81748638
64MAP3K60.81704843
65SGK2230.80701579
66SGK4940.80701579
67TAF10.79949653
68ATR0.78127974
69CAMK2B0.77452919
70CDK190.76464542
71CSNK1D0.73323173
72CAMK10.72245114
73SGK20.71687633
74AURKA0.70822971
75NEK20.69025830
76CAMK1D0.67886655
77BCR0.67416800
78BMPR20.65834744
79CSNK1A10.65136310
80SGK10.65034308
81PKN10.64258379
82PRKCZ0.63833555
83FGR0.62157563
84NME10.60962841
85PAK30.59461977
86ERBB20.58717907
87MKNK20.58357681
88ACVR1B0.57784695
89WNK30.57117540
90MAPK150.55337905
91CDK30.53295974
92MAP4K20.52750153
93MAPK80.52563014
94PRKDC0.51224525
95CDC42BPA0.50072831
96CCNB10.49890331
97TAOK10.48012321
98PRKAA10.47953707
99EPHA30.47815647
100TAOK30.46182493
101OXSR10.46019547
102PRKCE0.45831721
103NLK0.45703480
104CAMK1G0.45381794
105CAMK40.45240922
106RPS6KA20.43987135
107PRKACA0.43566081
108PLK40.43530908
109CSNK1G30.43030714
110SRPK10.42708733
111ICK0.42302083
112TAOK20.42229613
113AKT30.41879078
114RPS6KA30.40431903
115MAP3K20.39690075
116MAPK100.39681578
117RET0.38572232
118SGK30.38340657
119ADRBK10.37020484
120MKNK10.36878111
121FGFR20.36148732
122CSNK1E0.35796621
123ALK0.35364388
124MAP3K100.35183398
125MAPK140.35033351
126INSRR0.34696440
127PLK30.33919138
128FYN0.33499956
129GSK3B0.33212438
130BRSK10.32843805
131PRKCB0.32832797
132MAPK90.32360765
133PTK2B0.32255525
134ADRBK20.31122511
135PRKD20.30425617
136PRKCH0.30398619
137CSNK1A1L0.30267069

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.17655800
2Synaptic vesicle cycle_Homo sapiens_hsa047212.87766107
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.81552610
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.79716443
5Glutamatergic synapse_Homo sapiens_hsa047242.77073038
6Circadian entrainment_Homo sapiens_hsa047132.72647616
7GABAergic synapse_Homo sapiens_hsa047272.63110265
8Morphine addiction_Homo sapiens_hsa050322.56164338
9Olfactory transduction_Homo sapiens_hsa047402.54571962
10Long-term potentiation_Homo sapiens_hsa047202.53078538
11Amphetamine addiction_Homo sapiens_hsa050312.37584350
12Dopaminergic synapse_Homo sapiens_hsa047282.29021921
13Renin-angiotensin system_Homo sapiens_hsa046142.03958461
14Axon guidance_Homo sapiens_hsa043602.03341065
15Cholinergic synapse_Homo sapiens_hsa047251.98188904
16Serotonergic synapse_Homo sapiens_hsa047261.94583680
17Taste transduction_Homo sapiens_hsa047421.89611214
18Salivary secretion_Homo sapiens_hsa049701.88980805
19Long-term depression_Homo sapiens_hsa047301.78331105
20Insulin secretion_Homo sapiens_hsa049111.78078383
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74632015
22Fanconi anemia pathway_Homo sapiens_hsa034601.69447353
23Cocaine addiction_Homo sapiens_hsa050301.69288906
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67675386
25Oxytocin signaling pathway_Homo sapiens_hsa049211.65521909
26Renin secretion_Homo sapiens_hsa049241.62510152
27Calcium signaling pathway_Homo sapiens_hsa040201.58418212
28Gastric acid secretion_Homo sapiens_hsa049711.54938255
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52550482
30Gap junction_Homo sapiens_hsa045401.49058635
31Phototransduction_Homo sapiens_hsa047441.45220033
32GnRH signaling pathway_Homo sapiens_hsa049121.43259310
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39068694
34Melanogenesis_Homo sapiens_hsa049161.30971909
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.30551649
36ErbB signaling pathway_Homo sapiens_hsa040121.28930716
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25884245
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.21012542
39cAMP signaling pathway_Homo sapiens_hsa040241.19796434
40Type II diabetes mellitus_Homo sapiens_hsa049301.17228733
41Glioma_Homo sapiens_hsa052141.15512122
42Oxidative phosphorylation_Homo sapiens_hsa001901.14615033
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14030097
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10478073
45Butanoate metabolism_Homo sapiens_hsa006501.08972597
46Linoleic acid metabolism_Homo sapiens_hsa005911.08723727
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08113257
48Estrogen signaling pathway_Homo sapiens_hsa049151.06379315
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05981331
50Oocyte meiosis_Homo sapiens_hsa041141.05030089
51Wnt signaling pathway_Homo sapiens_hsa043101.01900923
52Parkinsons disease_Homo sapiens_hsa050121.00434104
53Collecting duct acid secretion_Homo sapiens_hsa049660.99196620
54Ether lipid metabolism_Homo sapiens_hsa005650.98557280
55Huntingtons disease_Homo sapiens_hsa050160.98206275
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96211941
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93181611
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92724786
59Nitrogen metabolism_Homo sapiens_hsa009100.91199772
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87377600
61Basal transcription factors_Homo sapiens_hsa030220.84092726
62Cardiac muscle contraction_Homo sapiens_hsa042600.83944540
63MAPK signaling pathway_Homo sapiens_hsa040100.81889354
64Choline metabolism in cancer_Homo sapiens_hsa052310.81694078
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81175631
66Colorectal cancer_Homo sapiens_hsa052100.80797757
67Hedgehog signaling pathway_Homo sapiens_hsa043400.79995083
68Alcoholism_Homo sapiens_hsa050340.77995592
69Ras signaling pathway_Homo sapiens_hsa040140.77964541
70Endometrial cancer_Homo sapiens_hsa052130.76475405
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.76395640
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.74660427
73Dorso-ventral axis formation_Homo sapiens_hsa043200.73518189
74Basal cell carcinoma_Homo sapiens_hsa052170.73291273
75RNA degradation_Homo sapiens_hsa030180.72819693
76Homologous recombination_Homo sapiens_hsa034400.72455679
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70845703
78VEGF signaling pathway_Homo sapiens_hsa043700.67568804
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66895389
80Selenocompound metabolism_Homo sapiens_hsa004500.65440553
81Rap1 signaling pathway_Homo sapiens_hsa040150.65349585
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.65310082
83Dilated cardiomyopathy_Homo sapiens_hsa054140.64101292
84Systemic lupus erythematosus_Homo sapiens_hsa053220.63390019
85Renal cell carcinoma_Homo sapiens_hsa052110.61014776
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60763629
87Chemical carcinogenesis_Homo sapiens_hsa052040.60688687
88Circadian rhythm_Homo sapiens_hsa047100.58108624
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58094996
90Glycerolipid metabolism_Homo sapiens_hsa005610.56663229
91Hippo signaling pathway_Homo sapiens_hsa043900.56086481
92Vibrio cholerae infection_Homo sapiens_hsa051100.55794044
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55650088
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55416506
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54389694
96Pancreatic secretion_Homo sapiens_hsa049720.52980619
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.52577006
98mTOR signaling pathway_Homo sapiens_hsa041500.52116168
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51957919
100Caffeine metabolism_Homo sapiens_hsa002320.50994432
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49921477
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49590044
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46568078
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45411967
105Melanoma_Homo sapiens_hsa052180.44876808
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44738520
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44285821
108Thyroid hormone synthesis_Homo sapiens_hsa049180.44071897
109Steroid biosynthesis_Homo sapiens_hsa001000.42696211
110African trypanosomiasis_Homo sapiens_hsa051430.42507909
111Non-small cell lung cancer_Homo sapiens_hsa052230.42183712
112Lysine degradation_Homo sapiens_hsa003100.41815128
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40788914
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40251038
115Pathways in cancer_Homo sapiens_hsa052000.40172387
116Glucagon signaling pathway_Homo sapiens_hsa049220.40107382
117Ovarian steroidogenesis_Homo sapiens_hsa049130.39834902
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39714413
119Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39205518
120RNA polymerase_Homo sapiens_hsa030200.37725086
121Notch signaling pathway_Homo sapiens_hsa043300.36223405
122Type I diabetes mellitus_Homo sapiens_hsa049400.36151858
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35889072
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35028792
125Insulin signaling pathway_Homo sapiens_hsa049100.34243938
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33934244
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33804633
128Prion diseases_Homo sapiens_hsa050200.33154600
129mRNA surveillance pathway_Homo sapiens_hsa030150.32004897
130Protein export_Homo sapiens_hsa030600.31988330
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31832333
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31634701
133Tryptophan metabolism_Homo sapiens_hsa003800.31474708
134Alzheimers disease_Homo sapiens_hsa050100.31369472

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