RNF166

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.38520910
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.94164637
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.94164637
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.78664416
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.49743601
6regulation of gamma-delta T cell differentiation (GO:0045586)5.45765609
7antigen processing and presentation via MHC class Ib (GO:0002475)5.25509748
8antigen processing and presentation of endogenous antigen (GO:0019883)5.12429330
9negative regulation of cell killing (GO:0031342)5.10493592
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.10493592
11positive regulation by symbiont of host defense response (GO:0052509)5.09540613
12modulation by symbiont of host defense response (GO:0052031)5.09540613
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.09540613
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.09540613
15positive regulation by organism of defense response of other organism involved in symbiotic interact5.09540613
16modulation by symbiont of host immune response (GO:0052553)5.09540613
17positive thymic T cell selection (GO:0045059)4.99031305
18regulation of gamma-delta T cell activation (GO:0046643)4.86096159
19neutrophil activation involved in immune response (GO:0002283)4.74608433
20detection of other organism (GO:0098543)4.65697176
21detection of bacterium (GO:0016045)4.61509940
22regulation of B cell receptor signaling pathway (GO:0050855)4.56107235
23negative T cell selection (GO:0043383)4.36781708
24DNA deamination (GO:0045006)4.33543768
25response to peptidoglycan (GO:0032494)4.27920388
26negative thymic T cell selection (GO:0045060)4.25461668
27negative regulation of lymphocyte mediated immunity (GO:0002707)4.22041987
28ribosomal small subunit assembly (GO:0000028)4.21672657
29leukocyte aggregation (GO:0070486)4.19322077
30macrophage activation involved in immune response (GO:0002281)4.18677520
31response to interleukin-15 (GO:0070672)4.14049580
32T cell migration (GO:0072678)4.05926572
33regulation of B cell differentiation (GO:0045577)4.03355104
34positive regulation of B cell differentiation (GO:0045579)4.02035611
35positive T cell selection (GO:0043368)4.01711980
36negative regulation of erythrocyte differentiation (GO:0045647)3.99763894
37sequestering of actin monomers (GO:0042989)3.99596929
38negative regulation of interleukin-12 production (GO:0032695)3.98450865
39Arp2/3 complex-mediated actin nucleation (GO:0034314)3.94518832
40thymic T cell selection (GO:0045061)3.92003352
41negative regulation of leukocyte mediated immunity (GO:0002704)3.85740182
42respiratory burst (GO:0045730)3.80346039
43neutrophil activation (GO:0042119)3.79660046
44detection of external biotic stimulus (GO:0098581)3.79283691
45cellular response to interleukin-15 (GO:0071350)3.77447173
46response to muramyl dipeptide (GO:0032495)3.77084879
47interferon-gamma production (GO:0032609)3.73852546
48mast cell activation (GO:0045576)3.73700374
49positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.71767626
50viral transcription (GO:0019083)3.71209712
51negative regulation of T cell mediated immunity (GO:0002710)3.71079663
52negative regulation of phagocytosis (GO:0050765)3.69263195
53regulation of T cell tolerance induction (GO:0002664)3.66496371
54positive regulation of lamellipodium assembly (GO:0010592)3.65640449
55activated T cell proliferation (GO:0050798)3.62697891
56cellular response to zinc ion (GO:0071294)3.61595739
57regulation of mast cell degranulation (GO:0043304)3.59044247
58regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.53695929
59response to type I interferon (GO:0034340)3.53385128
60T cell selection (GO:0045058)3.52184936
61immunoglobulin mediated immune response (GO:0016064)3.51072392
62translational termination (GO:0006415)3.50412930
63type I interferon signaling pathway (GO:0060337)3.49759563
64cellular response to type I interferon (GO:0071357)3.49759563
65regulation of necroptotic process (GO:0060544)3.48835207
66regulation of interferon-beta biosynthetic process (GO:0045357)3.48027052
67response to host immune response (GO:0052572)3.46973355
68response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.46973355
69myeloid cell activation involved in immune response (GO:0002275)3.46874582
70granulocyte activation (GO:0036230)3.46832658
71positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.44211514
72regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.43926701
73regulation of tolerance induction (GO:0002643)3.43702387
74regulation of type I interferon-mediated signaling pathway (GO:0060338)3.43646512
75leukocyte migration involved in inflammatory response (GO:0002523)3.43161008
76regulation of myeloid leukocyte mediated immunity (GO:0002886)3.38331402
77T cell homeostasis (GO:0043029)3.37534482
78detection of biotic stimulus (GO:0009595)3.33183573
79regulation of leukocyte degranulation (GO:0043300)3.28462826
80response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.28137812
81response to host (GO:0075136)3.28137812
82response to host defenses (GO:0052200)3.28137812
83regulation of mast cell activation involved in immune response (GO:0033006)3.26462583
84regulation of interleukin-12 biosynthetic process (GO:0045075)3.26205204
85regulation of T cell receptor signaling pathway (GO:0050856)3.26048890
86detection of molecule of bacterial origin (GO:0032490)3.25280901
87positive regulation of lamellipodium organization (GO:1902745)3.24374114
88barbed-end actin filament capping (GO:0051016)3.24076528
89regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.21655375
90regulation of natural killer cell mediated immunity (GO:0002715)3.21548401
91regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.21548401
92negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.20986641
93leukocyte degranulation (GO:0043299)3.20033679
94B cell receptor signaling pathway (GO:0050853)3.19359104
95regulation of alpha-beta T cell proliferation (GO:0046640)3.17244934
96negative regulation of innate immune response (GO:0045824)3.16739239
97negative regulation of necroptotic process (GO:0060546)3.16195889
98response to interferon-beta (GO:0035456)3.15668187
99myeloid dendritic cell activation (GO:0001773)3.15061254
100T cell receptor signaling pathway (GO:0050852)3.12726788
101regulation of isotype switching to IgG isotypes (GO:0048302)3.12572718
102microglial cell activation (GO:0001774)3.11655061
103regulation of response to interferon-gamma (GO:0060330)3.11413008
104translational elongation (GO:0006414)3.09836759
105negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.09750521
106antigen receptor-mediated signaling pathway (GO:0050851)3.09455689
107defense response to protozoan (GO:0042832)3.09348515
108response to protozoan (GO:0001562)3.07438630
109positive regulation of mast cell activation (GO:0033005)3.07242941
110regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.05698469
111natural killer cell differentiation (GO:0001779)3.04365162
112SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.03343559
113T cell costimulation (GO:0031295)3.03040261
114lymph node development (GO:0048535)3.01035429
115regulation of mast cell activation (GO:0033003)3.00975404
116cellular extravasation (GO:0045123)3.00726694
117mast cell degranulation (GO:0043303)3.00697244
118mast cell activation involved in immune response (GO:0002279)3.00697244
119response to interferon-alpha (GO:0035455)2.99991431
120positive regulation of granulocyte differentiation (GO:0030854)2.99899788
121lymphocyte costimulation (GO:0031294)2.99107313
122positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.98513739
123positive regulation of natural killer cell mediated immunity (GO:0002717)2.98513739
124macrophage activation (GO:0042116)2.98389591
125regulation of erythrocyte differentiation (GO:0045646)2.97661611
126positive regulation of tolerance induction (GO:0002645)2.96115503
127germinal center formation (GO:0002467)2.95994381
128Peyers patch development (GO:0048541)2.94145374
129mucosal-associated lymphoid tissue development (GO:0048537)2.94145374
130negative regulation of interleukin-6 production (GO:0032715)2.93873021
131protein targeting to ER (GO:0045047)2.93526834
132regulation of dendritic cell antigen processing and presentation (GO:0002604)2.93378809
133B cell mediated immunity (GO:0019724)2.93342113
134tolerance induction (GO:0002507)2.92931582
135regulation of regulatory T cell differentiation (GO:0045589)2.92881958
136cotranslational protein targeting to membrane (GO:0006613)2.92621003
137megakaryocyte development (GO:0035855)2.92613082
138regulation of T cell mediated cytotoxicity (GO:0001914)2.91841453
139regulation of necrotic cell death (GO:0010939)2.90773988
140positive regulation of T cell mediated cytotoxicity (GO:0001916)2.90508457
141positive regulation of macrophage differentiation (GO:0045651)2.89598390
142cellular response to interferon-beta (GO:0035458)2.88671167
143positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.86155661
144regulation of leukocyte mediated cytotoxicity (GO:0001910)2.85297522
145leukocyte cell-cell adhesion (GO:0007159)2.84597490
146natural killer cell activation (GO:0030101)2.84262575
147interferon-gamma-mediated signaling pathway (GO:0060333)2.84035997
148neutrophil mediated immunity (GO:0002446)2.83015498
149JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.82206910
150positive regulation of isotype switching (GO:0045830)2.82137672
151actin nucleation (GO:0045010)2.81861887
152negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.81363975
153establishment of protein localization to endoplasmic reticulum (GO:0072599)2.80607979
154regulation of regulated secretory pathway (GO:1903305)2.80349077
155positive regulation of natural killer cell differentiation (GO:0032825)2.79505266
156mature B cell differentiation involved in immune response (GO:0002313)2.79322718
157negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.79216070
158negative regulation of cytokine production involved in immune response (GO:0002719)2.79015637

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.08015501
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.60047077
3* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.31712546
4* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.23990179
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.10030047
6* MYC_22102868_ChIP-Seq_BL_Human3.01826001
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.98758624
8SCL_19346495_ChIP-Seq_HPC-7_Human2.95136052
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.86361720
10* VDR_21846776_ChIP-Seq_THP-1_Human2.74741086
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.72653498
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.67688693
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.60977381
14* MAF_26560356_Chip-Seq_TH1_Human2.54688130
15* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.51247377
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.48835258
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.45535737
18* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.40819460
19* MYB_26560356_Chip-Seq_TH2_Human2.40607460
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.39948584
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.32751517
22* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26639157
23* RUNX1_22412390_ChIP-Seq_EML_Mouse2.25274231
24* UTX_26944678_Chip-Seq_JUKART_Human2.25155330
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.22936270
26* VDR_24763502_ChIP-Seq_THP-1_Human2.21074540
27* SPI1_23547873_ChIP-Seq_NB4_Human2.20630006
28* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.20524250
29RUNX_20019798_ChIP-Seq_JUKART_Human2.19007783
30TCF7_22412390_ChIP-Seq_EML_Mouse2.17859827
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.17630458
32MYB_26560356_Chip-Seq_TH1_Human2.16816757
33* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16240427
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.11220404
35IRF8_27001747_Chip-Seq_BMDM_Mouse2.08769255
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.06992760
37* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.99466798
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.93770660
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89483585
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88137846
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.87611477
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.86534079
43* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.81998465
44* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.81308821
45* MAF_26560356_Chip-Seq_TH2_Human1.79120627
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.78249341
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77741856
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68234908
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63049003
50SPI1_23127762_ChIP-Seq_K562_Human1.62405316
51GATA1_22383799_ChIP-Seq_G1ME_Mouse1.60843070
52* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59221634
53* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.54959709
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54694887
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53188319
56* KDM2B_26808549_Chip-Seq_JURKAT_Human1.53043169
57GATA3_27048872_Chip-Seq_THYMUS_Human1.51194587
58* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51139455
59KDM2B_26808549_Chip-Seq_DND41_Human1.51126662
60GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.48255389
61* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47955359
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45054893
63* ELK3_25401928_ChIP-Seq_HUVEC_Human1.44599478
64* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35747825
65* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32198017
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31370107
67CIITA_25753668_ChIP-Seq_RAJI_Human1.29580984
68* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27776782
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23021437
70VDR_24787735_ChIP-Seq_THP-1_Human1.22929417
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22163199
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.21680719
73P68_20966046_ChIP-Seq_HELA_Human1.21665407
74* SA1_27219007_Chip-Seq_ERYTHROID_Human1.20881754
75PU_27001747_Chip-Seq_BMDM_Mouse1.19703191
76GATA1_22025678_ChIP-Seq_K562_Human1.19588626
77E2F7_22180533_ChIP-Seq_HELA_Human1.19238140
78* LXR_22292898_ChIP-Seq_THP-1_Human1.18041259
79GATA1_19941826_ChIP-Seq_K562_Human1.17613041
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.16696474
81PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14598240
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14376490
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13677783
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13581956
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13301244
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12669107
87ELF1_20517297_ChIP-Seq_JURKAT_Human1.10585983
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10175170
89BCL6_27268052_Chip-Seq_Bcells_Human1.10036951
90RACK7_27058665_Chip-Seq_MCF-7_Human1.08282994
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07880246
92IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05955647
93HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05346781
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05266725
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02437384
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01977684
97VDR_23849224_ChIP-Seq_CD4+_Human1.01977273
98* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01239958
99* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00305126
100MYC_18555785_ChIP-Seq_MESCs_Mouse0.95934036
101CTCF_26484167_Chip-Seq_Bcells_Mouse0.95837474
102SPI1_20517297_ChIP-Seq_HL60_Human0.95290940
103CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95256876
104GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94374780
105* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94273396
106* KDM2B_26808549_Chip-Seq_K562_Human0.94262237
107GATA3_26560356_Chip-Seq_TH2_Human0.92670627
108* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90969000
109SMC4_20622854_ChIP-Seq_HELA_Human0.90756272
110NCOR1_26117541_ChIP-Seq_K562_Human0.90047475
111FOXP3_21729870_ChIP-Seq_TREG_Human0.89140914
112ETS1_22383799_ChIP-Seq_G1ME_Mouse0.88423845
113SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87608144
114* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87472287
115SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86171061
116BCOR_27268052_Chip-Seq_Bcells_Human0.85951041
117MYC_18358816_ChIP-ChIP_MESCs_Mouse0.85210167
118CTCF_21964334_Chip-Seq_Bcells_Human0.83051959
119TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81928095
120CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81173158

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.63701159
2MP0005671_abnormal_response_to3.63068836
3MP0003763_abnormal_thymus_physiology3.46118942
4MP0000685_abnormal_immune_system3.37940382
5MP0009785_altered_susceptibility_to3.10354221
6MP0002396_abnormal_hematopoietic_system2.88422189
7MP0002166_altered_tumor_susceptibility2.71586322
8MP0005025_abnormal_response_to2.70931079
9MP0001800_abnormal_humoral_immune2.69940579
10MP0005000_abnormal_immune_tolerance2.56217122
11MP0002420_abnormal_adaptive_immunity2.55347827
12MP0001819_abnormal_immune_cell2.52815620
13MP0002723_abnormal_immune_serum2.51359857
14MP0002452_abnormal_antigen_presenting2.48206950
15MP0003436_decreased_susceptibility_to2.46261018
16MP0002398_abnormal_bone_marrow2.43596995
17MP0003724_increased_susceptibility_to2.37054376
18MP0002419_abnormal_innate_immunity2.33425073
19MP0001790_abnormal_immune_system2.32339619
20MP0005387_immune_system_phenotype2.32339619
21MP0005464_abnormal_platelet_physiology2.29792149
22MP0002405_respiratory_system_inflammati2.26284629
23MP0004808_abnormal_hematopoietic_stem2.18627122
24MP0003303_peritoneal_inflammation2.17512838
25MP0002148_abnormal_hypersensitivity_rea2.15063578
26MP0000716_abnormal_immune_system2.14790361
27MP0002006_tumorigenesis2.10324057
28MP0005397_hematopoietic_system_phenotyp2.04162568
29MP0001545_abnormal_hematopoietic_system2.04162568
30MP0000689_abnormal_spleen_morphology2.02861684
31MP0002722_abnormal_immune_system2.02039865
32MP0009333_abnormal_splenocyte_physiolog2.01642614
33MP0003300_gastrointestinal_ulcer1.99229888
34MP0010155_abnormal_intestine_physiology1.99135288
35MP0006082_CNS_inflammation1.97740566
36MP0004510_myositis1.92593213
37MP0001853_heart_inflammation1.90388031
38MP0008260_abnormal_autophagy1.89195134
39MP0000703_abnormal_thymus_morphology1.88929477
40MP0001873_stomach_inflammation1.85367770
41MP0002429_abnormal_blood_cell1.85106028
42MP0003866_abnormal_defecation1.81376767
43MP0001845_abnormal_inflammatory_respons1.68877511
44MP0005451_abnormal_body_composition1.67289722
45MP0005174_abnormal_tail_pigmentation1.63188533
46MP0004947_skin_inflammation1.62952740
47MP0000858_altered_metastatic_potential1.60907994
48MP0002933_joint_inflammation1.53400828
49MP0000343_altered_response_to1.52626155
50MP0000490_abnormal_crypts_of1.46154489
51MP0004381_abnormal_hair_follicle1.45410029
52MP0008469_abnormal_protein_level1.42190082
53MP0000465_gastrointestinal_hemorrhage1.38602706
54MP0005058_abnormal_lysosome_morphology1.33957586
55MP0005075_abnormal_melanosome_morpholog1.27777637
56MP0003172_abnormal_lysosome_physiology1.27672786
57MP0009278_abnormal_bone_marrow1.25900191
58MP0001533_abnormal_skeleton_physiology1.24077669
59MP0003448_altered_tumor_morphology1.15540569
60MP0001851_eye_inflammation1.13769901
61MP0002019_abnormal_tumor_incidence1.12924178
62MP0002132_abnormal_respiratory_system1.05547612
63MP0004883_abnormal_blood_vessel1.05409842
64MP0002277_abnormal_respiratory_mucosa1.03293206
65MP0001986_abnormal_taste_sensitivity1.02231620
66MP0005410_abnormal_fertilization1.00371207
67MP0005310_abnormal_salivary_gland0.97162805
68MP0003690_abnormal_glial_cell0.97155088
69MP0003279_aneurysm0.96990351
70MP0006054_spinal_hemorrhage0.93896781
71MP0002998_abnormal_bone_remodeling0.93650558
72MP0002009_preneoplasia0.91566782
73MP0003191_abnormal_cellular_cholesterol0.91506892
74MP0003656_abnormal_erythrocyte_physiolo0.89085133
75MP0003183_abnormal_peptide_metabolism0.88645951
76MP0005390_skeleton_phenotype0.87313256
77MP0003646_muscle_fatigue0.86216648
78MP0002095_abnormal_skin_pigmentation0.85194535
79MP0004130_abnormal_muscle_cell0.83388948
80MP0000371_diluted_coat_color0.83224086
81MP0009840_abnormal_foam_cell0.82932910
82MP0009763_increased_sensitivity_to0.80758143
83MP0001663_abnormal_digestive_system0.79284925
84MP0000015_abnormal_ear_pigmentation0.78821745
85MP0003828_pulmonary_edema0.78567236
86MP0000604_amyloidosis0.75504450
87MP0005164_abnormal_response_to0.73805994
88MP0000249_abnormal_blood_vessel0.70522747
89MP0005023_abnormal_wound_healing0.69894342
90MP0008007_abnormal_cellular_replicative0.68758644
91MP0005076_abnormal_cell_differentiation0.67789619
92MP0009764_decreased_sensitivity_to0.67364112
93MP0003693_abnormal_embryo_hatching0.66604901
94MP0003566_abnormal_cell_adhesion0.66512722
95MP0008004_abnormal_stomach_pH0.64923993
96MP0003806_abnormal_nucleotide_metabolis0.64126297
97MP0005166_decreased_susceptibility_to0.63951244
98MP0003075_altered_response_to0.63876138
99MP0003795_abnormal_bone_structure0.62719484
100MP0006036_abnormal_mitochondrial_physio0.61689212
101MP0004185_abnormal_adipocyte_glucose0.61634902
102MP0005584_abnormal_enzyme/coenzyme_acti0.61071334
103MP0000313_abnormal_cell_death0.60051794
104MP0003221_abnormal_cardiomyocyte_apopto0.58282812
105MP0008874_decreased_physiological_sensi0.57965508
106MP0002138_abnormal_hepatobiliary_system0.56354846
107MP0010352_gastrointestinal_tract_polyps0.56153039
108MP0000609_abnormal_liver_physiology0.55771337
109MP0009765_abnormal_xenobiotic_induced0.52130472
110MP0005319_abnormal_enzyme/_coenzyme0.51115717
111MP0000358_abnormal_cell_content/0.50990038
112MP0003186_abnormal_redox_activity0.50896237
113MP0000598_abnormal_liver_morphology0.50025587
114MP0004084_abnormal_cardiac_muscle0.49890070
115MP0003091_abnormal_cell_migration0.49496735
116MP0002136_abnormal_kidney_physiology0.49372082
117MP0003045_fibrosis0.49323949
118MP0000477_abnormal_intestine_morphology0.48395734
119MP0005381_digestive/alimentary_phenotyp0.46732628
120MP0002693_abnormal_pancreas_physiology0.45750667
121MP0009115_abnormal_fat_cell0.44394542
122MP0004858_abnormal_nervous_system0.41211661

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)5.05502833
2Elevated erythrocyte sedimentation rate (HP:0003565)4.81535471
3Abnormality of the nasal mucosa (HP:0000433)4.63638560
4Myositis (HP:0100614)4.56033931
5Recurrent bronchitis (HP:0002837)4.53448938
6Recurrent abscess formation (HP:0002722)4.40531718
7IgM deficiency (HP:0002850)4.10118950
8Eczematoid dermatitis (HP:0000976)3.95878959
9Gastrointestinal infarctions (HP:0005244)3.87622610
10Recurrent fungal infections (HP:0002841)3.75841886
11T lymphocytopenia (HP:0005403)3.74153706
12Thrombocytosis (HP:0001894)3.73785293
13Recurrent bacterial skin infections (HP:0005406)3.73718641
14Chronic otitis media (HP:0000389)3.70926960
15Abnormality of T cell number (HP:0011839)3.58955607
16Abnormality of T cells (HP:0002843)3.49594542
17Panhypogammaglobulinemia (HP:0003139)3.45550568
18Recurrent cutaneous fungal infections (HP:0011370)3.42493134
19Chronic mucocutaneous candidiasis (HP:0002728)3.42493134
20Recurrent viral infections (HP:0004429)3.32477440
21Bronchitis (HP:0012387)3.25040694
22Severe combined immunodeficiency (HP:0004430)3.21266770
23Recurrent skin infections (HP:0001581)3.17267531
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.12959299
25Abnormality of T cell physiology (HP:0011840)3.11208058
26Petechiae (HP:0000967)3.08232544
27Prolonged bleeding time (HP:0003010)3.08040970
28Keratoconjunctivitis sicca (HP:0001097)3.02493464
29Urticaria (HP:0001025)3.02169028
30Orchitis (HP:0100796)2.95236259
31Stomatitis (HP:0010280)2.91221574
32Combined immunodeficiency (HP:0005387)2.90515564
33Abnormal number of erythroid precursors (HP:0012131)2.89487881
34Abnormality of cells of the erythroid lineage (HP:0012130)2.88478860
35Gastrointestinal inflammation (HP:0004386)2.86308851
36Hypoplasia of the thymus (HP:0000778)2.85535926
37Inflammation of the large intestine (HP:0002037)2.84156181
38Hypochromic anemia (HP:0001931)2.82868493
39Spontaneous hematomas (HP:0007420)2.82745267
40Meningitis (HP:0001287)2.82471503
41Keratoconjunctivitis (HP:0001096)2.80309790
42Pustule (HP:0200039)2.76785967
43Episodic fever (HP:0001954)2.73387296
44Thyroiditis (HP:0100646)2.73082395
45IgG deficiency (HP:0004315)2.63476126
46Epistaxis (HP:0000421)2.63071916
47Obstructive lung disease (HP:0006536)2.59864056
48Chronic obstructive pulmonary disease (HP:0006510)2.59864056
49Mediastinal lymphadenopathy (HP:0100721)2.59398940
50Hypochromic microcytic anemia (HP:0004840)2.52816617
51Impaired platelet aggregation (HP:0003540)2.52730499
52Abnormal platelet function (HP:0011869)2.52730499
53Optic neuritis (HP:0100653)2.52237447
54Retrobulbar optic neuritis (HP:0100654)2.52237447
55Leukocytosis (HP:0001974)2.49523832
56Pulmonary embolism (HP:0002204)2.46081500
57Vacuolated lymphocytes (HP:0001922)2.45418265
58Lymphopenia (HP:0001888)2.44849677
59Increased IgM level (HP:0003496)2.43087856
60Thoracic kyphosis (HP:0002942)2.42767943
61Abnormality of macrophages (HP:0004311)2.40684540
62Abnormality of cells of the lymphoid lineage (HP:0012140)2.38902178
63Osteomyelitis (HP:0002754)2.38001959
64B lymphocytopenia (HP:0010976)2.37988976
65Abnormality of B cell number (HP:0010975)2.37988976
66Vasculitis (HP:0002633)2.37964287
67Chronic diarrhea (HP:0002028)2.34018038
68Recurrent gram-negative bacterial infections (HP:0005420)2.32978483
69Increased serum ferritin (HP:0003281)2.32953776
70Albinism (HP:0001022)2.32604465
71Anorexia (HP:0002039)2.32402646
72Hemoptysis (HP:0002105)2.30766175
73Recurrent sinusitis (HP:0011108)2.29549193
74Cellulitis (HP:0100658)2.27817663
75Amyloidosis (HP:0011034)2.26350660
76Abnormality of eosinophils (HP:0001879)2.25458966
77Aplastic anemia (HP:0001915)2.25034429
78Slow saccadic eye movements (HP:0000514)2.24111069
79Sepsis (HP:0100806)2.23729654
80Verrucae (HP:0200043)2.23482752
81Papilloma (HP:0012740)2.23482752
82Chest pain (HP:0100749)2.22891720
83Agammaglobulinemia (HP:0004432)2.22573041
84Arterial thrombosis (HP:0004420)2.19724707
85Hypergammaglobulinemia (HP:0010702)2.17755146
86Dysostosis multiplex (HP:0000943)2.13953057
87Interstitial pulmonary disease (HP:0006530)2.10447277
88Abnormality of the fingertips (HP:0001211)2.09740767
89Ragged-red muscle fibers (HP:0003200)2.09197365
90Pulmonary infiltrates (HP:0002113)2.08115069
91Gingivitis (HP:0000230)2.06478828
92Gingival bleeding (HP:0000225)2.06219414
93Bronchiectasis (HP:0002110)2.05420520
94Abnormality of iron homeostasis (HP:0011031)2.04808241
95Peritonitis (HP:0002586)2.04665944
96Colitis (HP:0002583)2.04334957
97Autoimmune hemolytic anemia (HP:0001890)2.03319519
98Microcytic anemia (HP:0001935)2.03116855
99Viral hepatitis (HP:0006562)2.02961527
100Fatigue (HP:0012378)2.02333452
101Gastrointestinal stroma tumor (HP:0100723)2.02218136
102Increased cerebral lipofuscin (HP:0011813)2.01520983
103Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.01515353
104Decreased activity of mitochondrial respiratory chain (HP:0008972)2.01515353
105Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.00221067
106Skin ulcer (HP:0200042)1.99834517
107Hypoproteinemia (HP:0003075)1.99492398
108Abnormality of liposaccharide metabolism (HP:0010968)1.99000199
109Abnormality of glycosphingolipid metabolism (HP:0004343)1.99000199
110Abnormality of glycolipid metabolism (HP:0010969)1.99000199
111Abnormality of the pleura (HP:0002103)1.98621200
112Hepatosplenomegaly (HP:0001433)1.96680603
113Glomerulopathy (HP:0100820)1.95196181
114Loss of speech (HP:0002371)1.94762642
115Asymmetric septal hypertrophy (HP:0001670)1.94605732
116Increased neuronal autofluorescent lipopigment (HP:0002074)1.93765850
117Muscle fiber atrophy (HP:0100295)1.93368733
118Encephalitis (HP:0002383)1.93237005
119Chronic sinusitis (HP:0011109)1.91159106
120Abnormality of the thoracic spine (HP:0100711)1.90836906
121Acne (HP:0001061)1.90470293
122Abnormality of the peritoneum (HP:0002585)1.89660684
123Mucopolysacchariduria (HP:0008155)1.89340883
124Urinary glycosaminoglycan excretion (HP:0003541)1.89340883
125Hypertensive crisis (HP:0100735)1.89039341
126Spondylolisthesis (HP:0003302)1.88870602
127Autoimmune thrombocytopenia (HP:0001973)1.88291943
128Increased IgE level (HP:0003212)1.88114680
129Deformed sella turcica (HP:0002681)1.87514457
130Abnormal platelet volume (HP:0011876)1.87291015
131Premature loss of primary teeth (HP:0006323)1.87238235
132Papilledema (HP:0001085)1.86360209
133Granulocytopenia (HP:0001913)1.83890888
134Polygenic inheritance (HP:0010982)1.83813192
135Eosinophilia (HP:0001880)1.83744585
136Hematochezia (HP:0002573)1.82068132
137Purpura (HP:0000979)1.81586474

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.57330966
2TXK3.04377201
3PRPF4B2.99784719
4ZAP702.82166498
5KIT2.64424983
6JAK32.61557511
7NME22.48742812
8EEF2K2.47018334
9TBK12.43898989
10TRIB32.42930973
11TYK22.38994054
12IKBKE2.16323658
13PKN22.12197651
14ERN12.12195137
15FLT31.99059314
16BTK1.97401695
17TEC1.89554085
18PIM21.89539262
19MAP3K121.81920797
20KDR1.81156003
21MAP2K31.59165591
22FGFR41.56176161
23ITK1.56104208
24LRRK21.54866592
25SIK31.50230366
26SYK1.44984640
27MAP3K31.39347522
28TGFBR21.36963041
29IRAK41.36779809
30MAP3K101.36123687
31BLK1.36038878
32STK101.33618752
33LCK1.32783575
34JAK11.29194242
35GRK61.29186921
36SCYL21.27663687
37TTN1.26755173
38ACVR1B1.25970723
39CSF1R1.23156963
40FGR1.22157886
41IKBKB1.20881065
42MAP3K11.17944743
43SMG11.16234382
44MARK21.15207274
45MAPKAPK31.14540356
46NLK1.14282707
47HCK1.12683631
48MYLK1.09237675
49CSK1.08091809
50PRKD21.02603474
51TESK11.02092775
52KSR21.00208696
53SIK10.99376306
54TGFBR10.97175029
55RPS6KA40.95633211
56TESK20.95423224
57STK160.94827741
58FES0.93807783
59TAOK30.93489773
60FGFR30.92589727
61PIM10.87436226
62CAMKK10.87152474
63MAP3K110.85690174
64JAK20.82829132
65ILK0.82527234
66MAPK120.82308096
67TNK20.81062380
68CDC42BPA0.80093150
69PAK40.79829931
70MAP3K140.79330106
71IRAK30.78797578
72LYN0.78120811
73RIPK40.77812731
74DMPK0.77322189
75PDPK10.76828526
76TAOK20.75518216
77MAP3K130.75466184
78BCKDK0.73120469
79CDK120.71656677
80YES10.67952300
81RAF10.67484297
82IRAK20.66891084
83MAPK70.66807210
84PRKG20.66054410
85MAP2K20.65459954
86PDK10.64521224
87PDK40.63508118
88PDK30.63508118
89MAP2K60.63359965
90MAPK110.62891831
91TAOK10.62406121
92DYRK30.60065828
93FYN0.59738484
94IRAK10.59023605
95PASK0.58722111
96DYRK1B0.58178251
97NEK20.57752741
98HIPK20.56840100
99MAP3K70.56793939
100SIK20.56228343
101MAP3K60.56074905
102RIPK10.54916016
103MATK0.53534812
104CDK190.52419846
105MUSK0.51489599
106CDK40.50290583
107EPHB10.49963891
108MAPK40.49490564
109RPS6KB20.48665849
110STK110.48582221
111RET0.48314021
112DAPK30.48200315
113STK380.45790781
114DAPK10.45426668
115RPS6KA60.43622552
116PTK60.42697020
117ICK0.42617407
118LMTK20.40730886
119NEK90.40165619
120CAMKK20.39837111
121PIK3CG0.39590165
122BMPR20.39175922
123RPS6KL10.36996223
124RPS6KC10.36996223
125SGK30.36586274
126PRKCQ0.35750927
127PTK2B0.34871891
128MARK30.34071010
129ADRBK20.33878764
130CAMK40.33519543
131MAPKAPK20.33468920
132MAP3K50.33271786
133CDK60.33002152
134CHUK0.31094958
135PRKCH0.30528515

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.31752905
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.82185759
3Leishmaniasis_Homo sapiens_hsa051402.66527836
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.65560062
5Antigen processing and presentation_Homo sapiens_hsa046122.64390902
6Ribosome_Homo sapiens_hsa030102.62089833
7Measles_Homo sapiens_hsa051622.43101804
8Osteoclast differentiation_Homo sapiens_hsa043802.32668522
9B cell receptor signaling pathway_Homo sapiens_hsa046622.30013593
10T cell receptor signaling pathway_Homo sapiens_hsa046602.23910096
11Hematopoietic cell lineage_Homo sapiens_hsa046402.14053755
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.04945043
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.01349493
14Other glycan degradation_Homo sapiens_hsa005111.98997708
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.86505259
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.81262592
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.79040949
18Acute myeloid leukemia_Homo sapiens_hsa052211.65795792
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.62415660
20Herpes simplex infection_Homo sapiens_hsa051681.59955365
21Type I diabetes mellitus_Homo sapiens_hsa049401.59351171
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.57826825
23Toxoplasmosis_Homo sapiens_hsa051451.44647019
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41458538
25Shigellosis_Homo sapiens_hsa051311.41128373
26Platelet activation_Homo sapiens_hsa046111.40039237
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39873299
28DNA replication_Homo sapiens_hsa030301.38574129
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.35474224
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34404092
31Viral myocarditis_Homo sapiens_hsa054161.29685336
32Legionellosis_Homo sapiens_hsa051341.28689868
33Graft-versus-host disease_Homo sapiens_hsa053321.28014062
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.27685405
35Influenza A_Homo sapiens_hsa051641.24765665
36Chemokine signaling pathway_Homo sapiens_hsa040621.23667243
37Sulfur relay system_Homo sapiens_hsa041221.23099281
38Allograft rejection_Homo sapiens_hsa053301.22979301
39Hepatitis B_Homo sapiens_hsa051611.22834823
40Apoptosis_Homo sapiens_hsa042101.19587503
41Tuberculosis_Homo sapiens_hsa051521.18594345
42Malaria_Homo sapiens_hsa051441.12854397
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09727904
44Phagosome_Homo sapiens_hsa041451.08269844
45Pertussis_Homo sapiens_hsa051331.05850985
46Staphylococcus aureus infection_Homo sapiens_hsa051501.05134934
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03462882
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00681515
49Chronic myeloid leukemia_Homo sapiens_hsa052201.00059704
50VEGF signaling pathway_Homo sapiens_hsa043700.98747315
51TNF signaling pathway_Homo sapiens_hsa046680.97178440
52Salmonella infection_Homo sapiens_hsa051320.96682034
53Lysosome_Homo sapiens_hsa041420.92121181
54Pentose phosphate pathway_Homo sapiens_hsa000300.91152024
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89609232
56Caffeine metabolism_Homo sapiens_hsa002320.88969098
57HTLV-I infection_Homo sapiens_hsa051660.88502624
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87622896
59African trypanosomiasis_Homo sapiens_hsa051430.85365198
60Pancreatic cancer_Homo sapiens_hsa052120.84892686
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84006245
62Renal cell carcinoma_Homo sapiens_hsa052110.82835488
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.82409333
64Rheumatoid arthritis_Homo sapiens_hsa053230.81764289
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81631299
66Asthma_Homo sapiens_hsa053100.79011792
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78814928
68Choline metabolism in cancer_Homo sapiens_hsa052310.78769293
69Base excision repair_Homo sapiens_hsa034100.76219987
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.76168153
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.73906486
72Endometrial cancer_Homo sapiens_hsa052130.72778329
73Thyroid cancer_Homo sapiens_hsa052160.72385061
74Prolactin signaling pathway_Homo sapiens_hsa049170.71935782
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71247062
76mTOR signaling pathway_Homo sapiens_hsa041500.70545173
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67713355
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.66478882
79Inositol phosphate metabolism_Homo sapiens_hsa005620.66156591
80GnRH signaling pathway_Homo sapiens_hsa049120.64654826
81Viral carcinogenesis_Homo sapiens_hsa052030.62525422
82Epstein-Barr virus infection_Homo sapiens_hsa051690.61848093
83Non-homologous end-joining_Homo sapiens_hsa034500.60658060
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60416052
85Non-small cell lung cancer_Homo sapiens_hsa052230.60379621
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59471634
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.58296652
88Insulin resistance_Homo sapiens_hsa049310.57063973
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56807298
90N-Glycan biosynthesis_Homo sapiens_hsa005100.55898771
91MAPK signaling pathway_Homo sapiens_hsa040100.55887046
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54717539
93Homologous recombination_Homo sapiens_hsa034400.49761969
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48641837
95Colorectal cancer_Homo sapiens_hsa052100.48558510
96ErbB signaling pathway_Homo sapiens_hsa040120.46990539
97Endocytosis_Homo sapiens_hsa041440.46745325
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46744039
99Notch signaling pathway_Homo sapiens_hsa043300.46719471
100Hepatitis C_Homo sapiens_hsa051600.46014895
101p53 signaling pathway_Homo sapiens_hsa041150.45885095
102Rap1 signaling pathway_Homo sapiens_hsa040150.45197633
103Pyrimidine metabolism_Homo sapiens_hsa002400.44972511
104Regulation of autophagy_Homo sapiens_hsa041400.44941571
105Amoebiasis_Homo sapiens_hsa051460.44608926
106Spliceosome_Homo sapiens_hsa030400.44126377
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42329775
108HIF-1 signaling pathway_Homo sapiens_hsa040660.41452267
109Mismatch repair_Homo sapiens_hsa034300.40152363
110Type II diabetes mellitus_Homo sapiens_hsa049300.38760260
111Glioma_Homo sapiens_hsa052140.37831376
112RNA degradation_Homo sapiens_hsa030180.37565575
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37089985
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35760490
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35108105
116Protein export_Homo sapiens_hsa030600.34001075
117Small cell lung cancer_Homo sapiens_hsa052220.31640809
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31275061
119Galactose metabolism_Homo sapiens_hsa000520.31139129
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28981575
121FoxO signaling pathway_Homo sapiens_hsa040680.23924686
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23766325
123Autoimmune thyroid disease_Homo sapiens_hsa053200.21062612
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20416664
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.20318870
126Proteasome_Homo sapiens_hsa030500.19519269
127Insulin signaling pathway_Homo sapiens_hsa049100.18166187

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